@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_17_0440: (2018-03-09 )
MQHLEAAAAAAAANSDGTCSLTGCVCPGKNNKELFSCRPDGVASVYDNHEEDLIDGDAGESGSRTGGLSRERTGTDLLSVKSAGASVRRGKDEVDVAAKGIPLEVRRFQCTKSILAFKEATKNDATPVPAKLVDFIVSLTSSKNGLCTEKEMCDWLVAQMCDRMETGQVWVIGKTSNLLFALLWRGSRNFIESVHASGASLFQVSHLADVIKQTPQGNISGDRLPGSLQPIKHGSAGRKSARSRRKSANIVGGNGAVKPLTACFLEQLKLKGMCSSGAASWLSQGNEALPVHIDPTFDIPEREICFFITNTAYMEALCEYRFRHPALDLVRGEILCDSDDCSVSDSAGQASDFSSCRTTPASWKGLLDDTLELIKTVAATDPSILICPTGVAIATIRLRNAVLLYEVACRALVRLVHSIFTSLRTLVNSVQTESGAPLTRTQTTRAEQPPTAITSSGCGDSSRLADIGARVDLTLSPEAALGLVNMHYSAMYQFNCAVRTFKTYCESAQHVSAEVSKKAAAALKLIPEDDFAAFRETLKQLQGNGCAKTADASHTATQPLPHQATSSSGVLSPSAAGATEGRATEVCGPLSTVAVDGASLPTPATSSRESGAHSTTLLDAGVRDALLMLYEFNSAQEGEQPPMWSRQVDAVCALFDEKEAAILHRIFQDGLDGLWSQWRDFTNNALAAAEKALTTPCESTSPAAKRENSSVQGFLSSDGSAPESGGHHGSYGDATARNPAHAFRSLPSEPQCLQATGFGSSDDKTDFVSPSSSSANNSSLSVAGAEKSAERSIEALLQAEDVVVICNEECSCNDTLKLIDRFQILMDVPLGQGSYGKVFRAWDEVTGCYLAAKELPLDSSKAHSVAVREVLQEYTVLTELSHPNIVRVVAFMVMKETARIYMEWMPSGSLQDVLRHHPRGVLRESVVRRYARDVVSGLAYLHSRGVIHRDVKPANMLLSSDGTVKLTDFGTSLVLSDNNRTLKSNALAGTAAYMAPECVQGTYSSASDIWSFGCSVVQLITGHLPWYNAQTGTSPEPIALLFKIGCLDDTTHLERPHDPLVTTVAAANTAAEASASFDATLSNSNTASMTGSFASTSSKSFRAALPATTVTSPPEISQELIHMLNAIFVVDRKKRPSARELMHHPFFKFM
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......--800.......810......-------.820.......830.......840.......850.......860----.----.--......870.......880-........890..----.....900.......910.......920.......930.......940.-..--....950......--.-960..----.-......970.......980.......990.......-1000----.--.--.......1010......1020......1030......1040......1050----.......1060......1070------........1080......-------------1090......1100......1110......1120......1130...-----...1140......1150
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MQ
H
L
E
A
A
A
A
AAAANSDG
T
C
S
L
T
G
C
VCPGKNN
K
E
L
F
SCRPDG
V
A
S
V
YDNH
E
E
DLIDGDAGESGSRTGGLSRERTGT
D
L
L
S
VKSAGASVRRGKDEVDVAAKGIP
L
E
V
R
R
F
Q
C
T
K
S
I
L
A
F
K
E
ATKNDATPV
P
A
K
L
V
D
F
I
V
S
L
TSSKNGLC
T
E
K
E
M
C
D
W
L
V
A
Q
M
C
DRMETG
Q
V
W
V
I
GKTS
N
L
L
F
A
L
L
WRG
S
R
N
F
I
E
S
V
H
ASGA
S
L
F
Q
V
S
H
L
A
D
V
I
K
QTPQGNISGDRLPGSLQPIKHGSAG
R
K
S
A
R
S
RRKSANIVGGNGA
V
K
P
L
T
A
C
F
L
E
Q
L
K
LKGMCS
S
G
A
A
S
W
L
SQGN
E
A
L
P
V
HIDPTFDIPE
R
E
I
C
F
F
IT
N
T
A
Y
M
E
A
L
C
E
Y
RFRHP
A
L
D
LVR
G
E
I
L
CDSDDCSVSDSAGQASDFSSCRTT
P
A
S
W
K
G
L
L
D
D
T
L
E
L
I
K
T
V
AATDP
S
I
L
I
CPTG
V
A
I
A
T
I
R
LRN
A
V
L
L
Y
E
V
A
C
R
A
L
V
R
L
V
H
S
I
F
T
S
L
R
T
L
V
N
S
VQTESGAPLTRTQTTRAEQPPTAITSSGCGD
S
S
R
L
A
DIG
A
R
V
D
L
T
LSP
E
A
A
L
G
L
V
N
M
H
Y
S
A
M
Y
Q
F
N
C
A
V
R
T
F
K
T
Y
C
E
S
A
Q
H
V
S
A
E
V
S
K
K
A
A
A
A
L
KLIPE
D
D
F
A
A
F
R
E
T
L
K
Q
L
QGNGCAKTADASHTATQPLPHQATSSSGVLSPSAAGATEGRATEVCGP
L
S
T
VAVDGASLPTPATSSRESGAHS
T
T
L
L
D
A
G
V
R
D
A
L
L
M
L
Y
EFNSAQEGEQPPM
W
S
R
Q
V
D
A
V
C
A
L
FDE
K
E
A
A
I
L
H
R
I
F
Q
D
G
L
D
G
L
W
S
Q
W
R
D
FTN
N
A
L
A
A
A
E
K
A
LTTPCESTSPAAKRENSSV
Q
G
F
LSSDGSAPESGGHHGSYGDATAR
N
P
A
H
A
F
RSLPSEPQ
C
L
Q
ATGFGSSDDKTDFVSPSSSSANNS
S
L
S
VAGA
E
K
S
A
E
R
S
I
E
A
L
LQA--E
D
V
V
V
I
CNEECSCN
D
T
L
K
L
-------
I
D
R
F
Q
I
L
M
DVPLGQGS
Y
G
K
V
F
R
A
W
D
E
V
T
G
C
Y
L
A
A
K
ELPLDSSK-----
A
----
H
--
S
V
A
V
R
E
V
L
Q
E
Y
T
V
L
TEL-S-HP
N
I
V
R
V
V
A
F
M
V
M
----
K
E
T
A
R
I
Y
M
EWMPSG
S
L
Q
D
V
L
R
HH
P
R
G
V
L
R
E
S
V
V
R
R
Y
A
R
D
V
V
S
G
L
A
Y
L
H
S-RG--VIHRDVK
P
A
N
M
L
L--S-S--DG----
T
-
V
K
L
T
DFG
T
S
L
V
LSDNN
R
T
LKSNALAG
T
A
A
YMA
P
E
C
V-Q-------G--T--YS
S
A
S
D
I
W
S
F
G
C
S
V
V
Q
L
I
T
GHLPWYNAQTGTSPE
P
I
A
L
L
F
K
IGCLDDTTH-----LERPHDP
L
V
T
T
V
AAANTAA--------EASAS
F
D
A
TLSNSNTA
S
M
-------------TGSFASTSSKS
F
R
AALPATTVTS
P
P
E
I
S
Q
E
L
I
H
M
L
N
A
I
F
V
VDRKKRP-----
S
A
R
E
L
M
HHP
F
F
KFM
29
HHSearch
78.30
33%
-92
- C1 -
-
5J5T
1
M4K3_HUMAN
A:
[4-267]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
F
E
L
I
--
Q
R
I
G
S
G
T
Y
G
D
V
Y
K
A
R
N
V
N
T
G
E
L
A
A
I
K
V
I
K
L
E
P
G
---------------
E
D
F
A
V
V
Q
Q
E
I
I
M
M
K
D
C
-
K
-
H
P
N
I
V
A
Y
F
G
S
Y
L
R
----
R
D
K
L
W
I
C
M
E
F
C
G
G
G
S
L
Q
D
I
Y
H
V
T
--
G
P
L
S
E
L
Q
I
A
Y
V
S
R
E
T
L
Q
G
L
Y
Y
L
H
S
-
K
G
--
K
M
H
R
D
I
K
G
A
N
I
L
L
--
T
-
D
--
N
G
----
H
-
V
K
L
A
D
F
G
V
S
A
Q
I
T
A
T
I
--
A
---
A
F
I
G
T
P
Y
W
M
A
P
E
V
A
-
A
V
ERK---
G
--
G
--
Y
N
Q
L
C
D
L
W
A
V
G
I
T
A
I
E
L
A
E
L
Q
P
P
M
F
D
L
H
P
------
M
R
A
L
F
L
M
T
K
S
-----------
N
F
Q
--
P
---------------------------------------------------------------------
P
K
L
K
D
K
M
K
W
S
N
S
F
H
H
F
V
K
M
A
L
T
K
N
P
K
K
R
P
-----
T
A
E
K
L
L
Q
H
P
F
V
T
Q
-
44
HHSearch
76.39
31%
-48
- C1 -
-
4GV1
5
AKT1_HUMAN
A:
[7-275]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
N
E
F
E
Y
L
--
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
T
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
----------
A
--
K
D
E
V
A
H
T
L
T
E
N
R
V
L
Q
N
S
-
R
-
H
P
F
L
T
A
L
K
Y
S
F
Q
T
----
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
--
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
--
V
V
Y
R
D
L
K
L
E
N
L
M
L
--
D
-
K
--
D
G
----
H
-
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
--
A
T
M
K
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
-
E
D------
N
--
D
--
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
------
E
K
L
F
E
L
I
L
M
E
------------
E
I
---------------------------------------------------------------------------
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
GGGS
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
-
31
HHSearch
72.10
29%
-100
- C1 -
-
4XBR
1
INKA1_HUMAN (first)
A:
[93-349]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
Y
L
D
N
F
--
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
Q
---------------
Q
R
R
E
L
L
F
N
E
V
V
I
M
R
D
Y
-
Q
-
H
E
N
V
V
E
M
Y
N
S
Y
L
V
----
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
T
---
R
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
-
Q
G
--
V
I
H
R
D
I
K
S
D
S
I
L
L
--
T
-
H
--
D
G
----
R
-
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
--
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
-
S
R------
L
--
P
--
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
------
L
K
A
M
K
M
I
R
D
N
------------
L
P
--
P
-------------------------------------------------------------
R
---------
L
K
N
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
-----
T
A
A
E
L
L
K
H
P
F
L
A
K
-
11
PsiBlast_PDB
70.20
29%
-9
- C1 -
-
3NIZ
1
?
A:
[19-305]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-------
M
E
K
Y
Q
K
L
E
K
V
--
G
E
G
T
Y
G
V
V
Y
K
A
K
D
S
-
Q
G
R
I
V
A
L
K
R
I
R
---------------
G
I
P
S
T
A
I
R
E
I
----
S
L
L
K
E
L
-
H
-
H
P
N
I
V
S
L
I
D
V
I
H
S
----
E
R
C
L
T
L
V
F
E
F
M
E
K
-
D
L
K
K
V
L
D
E
N
K
T
G
-
L
Q
D
S
Q
I
K
I
Y
L
Y
Q
L
L
R
G
V
A
H
C
H
Q
-
H
R
--
I
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
-
S
--
D
G
----
A
-
L
K
L
A
D
F
G
L
A
R
A
F
G
I
P
V
R
---
H
E
V
V
--
T
L
W
Y
R
A
P
D
V
L
-
M
-------
G
--
S
KK
Y
S
T
S
V
D
I
W
S
I
G
C
I
F
A
E
M
I
T
G
-------------
K
P
---
L
F
P
-
G
V
T
D
D
D
-----------
Q
L
P
K
I
F
S
I
L
G
T
P
N
P
R
--------
E
W
P
Q
V
Q
E
L
P
L
W
K
Q
R
T
-------------------
F
Q
V
F
E
K
K
P
W
S
S
I
I
P
G
--------
F
C
Q
E
G
I
D
L
L
S
N
M
L
C
F
D
P
N
K
R
I
-----
S
A
R
D
A
M
N
H
P
Y
F
K
--
10
PsiBlast_PDB
69.91
29%
-75
- C1 -
-
2QKR
-
?
A:
[19-305]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-------
M
E
K
Y
--
L
E
K
V
--
G
E
G
---
V
V
Y
K
A
K
D
S
-
Q
-
R
I
V
A
L
K
R
I
-------------------
S
T
A
I
R
E
I
----
S
L
L
K
E
L
-
H
-
H
P
N
I
V
S
L
I
D
V
I
H
S
----
E
-
C
L
T
L
V
F
E
F
M
E
K
-
D
L
K
K
V
L
D
E
N
K
T
G
-
L
Q
D
S
Q
I
K
I
Y
L
Y
Q
L
L
R
G
V
A
H
C
H
Q
-
H
R
--
I
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
-
S
--
D
-----
A
-
L
K
L
A
D
F
G
L
A
R
A
F
G
I
P
V
R
-----
V
V
--
T
L
W
Y
R
A
P
D
V
L
-
M
-------
G
--
S
KK
Y
S
T
S
V
D
I
W
S
I
G
C
I
F
A
E
M
I
T
G
-------------
K
P
---
L
F
P
-
G
V
T
D
D
D
-----------
Q
L
P
K
I
F
S
I
L
G
T
P
N
P
R
--------
E
W
P
Q
V
Q
E
L
P
L
W
K
Q
R
T
-------------------
F
Q
V
F
E
K
K
P
W
S
S
I
I
P
G
--------
F
C
Q
E
G
I
D
L
L
S
N
M
L
C
F
D
P
N
K
R
I
-----
S
A
R
D
A
M
N
H
P
Y
F
K
--
23
HHSearch
67.20
25%
-36
- C1 -
-
2Y7J
1
PHKG2_HUMAN
D:
[92-365]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
-------
Y
Q
K
Y
D
P
K
--
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
V
---
R
-----
L
SPEQ
L
--
E
E
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
A
G
-
H
P
H
I
I
T
L
I
D
S
Y
E
S
----
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
--
V
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
-
N
N
--
I
V
H
R
D
L
K
P
E
N
I
L
L
--
D
-
D
--
N
M
----
Q
-
I
R
L
S
D
F
G
F
S
C
H
L
E
P
G
E
---
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
-
K
CSMDETH
P
--
G
--
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
R
R
Q
------
I
L
M
L
R
M
I
M
E
G
-----------
Q
Y
Q
--
F
-----------------------------------------------------------------
S
-----
S
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
-----
T
A
E
Q
A
L
Q
H
P
F
F
E
R
-
17
PsiBlast_PDB
66.98
32%
-113
- C1 -
-
4ZJJ
1
PAK1_HUMAN
A:
[15-242]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
V
G
D
P
K
K
K
-------
Y
T
R
F
E
-----
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
-------------
K
--
E
L
I
I
N
E
I
L
----
V
M
R
E
N
-
K
-
N
P
N
I
V
N
Y
L
D
S
Y
L
V
----
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
---
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
Q
--
V
I
H
R
D
I
K
S
D
N
I
L
L
--
G
-
M
--
D
G
----
S
-
V
K
L
T
D
F
G
F
C
A
Q
I
T
---------
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
-------
K
--
A
--
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
------
P
L
R
A
L
Y
L
I
A
T
-
N
G
T
P
E
-----
L
Q
N
P
E
-----------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
66.61
32%
-115
- C1 -
-
4ZJI
1
PAK1_HUMAN
A:
[15-242]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
V
G
D
P
K
K
K
-------
Y
T
R
F
E
-----
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
--------------
K
--
E
L
I
I
N
E
I
L
----
V
M
R
E
N
-
K
-
N
P
N
I
V
N
Y
L
D
S
Y
L
V
----
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
---
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
Q
--
V
I
H
R
D
I
K
S
D
N
I
L
L
--
G
-
M
--
D
G
----
S
-
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
--------
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
-------
K
--
A
--
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
------
P
L
R
A
L
Y
L
I
A
T
-
N
G
T
P
E
-----
L
Q
N
P
E
-----------------------------------------------------------------------------------------------------------------------
46
Fugue
66.05
25%
-59
- C1 -
-
4DN5
7
M3K14_HUMAN
A:
[8-351]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
E
E
Y
L
V
H
A
L
Q
G
S
V
S
S
G
Q
A
H
S
L
T
S
L
A
K
T
W
A
A
R
G
S
R
S
R
E
P
S
P
K
T
E
D
--
N
E
G
V
L
L
T
E
K
L
K
P
V
D
Y
E
Y
R
E
-------
E
V
H
W
A
T
H
Q
L
-
R
L
G
R
G
S
F
G
E
V
H
R
M
E
D
K
Q
T
G
F
Q
C
A
V
K
K
V
R
L
E
V
F
R
-----
A
---------------
E
E
L
M
A
C
A
G
L
-
T
-
S
P
R
I
V
P
L
Y
G
A
V
R
E
----
G
P
W
V
N
I
F
M
E
L
L
E
G
G
S
L
G
Q
L
V
K
E
Q
--
G
C
L
P
E
D
R
A
L
Y
Y
L
G
Q
A
L
E
G
L
E
Y
L
H
S
-
R
R
--
I
L
H
G
D
V
K
A
D
N
V
L
L
--
S
-
S
--
D
G
----
S
H
A
A
L
C
D
F
G
H
A
V
C
L
Q
----------
I
P
G
T
E
T
H
M
A
P
E
V
V
-
L
-------
G
--
R
S-
C
D
A
K
V
D
V
W
S
S
C
C
M
M
L
H
M
L
N
G
C
H
P
W
T
Q
------
F
F
R
G
P
L
C
L
K
I
A
S
E
P
P
P
V
R
EIPPS
C
A
P
L
T
A
Q
A
I
Q
E
G
L
R
K
E
P
I
H
--------
R
V
S
A
A
E
L
G
G
K
V
N
R
A
L
Q
Q
V
-------------
G
G
L
K
S
P
W
R
G
E
Y
K
E
P
R
H
P
-------------------------------------------------
24
HHSearch
65.99
25%
-33
- C1 -
-
2Y7J
1
PHKG2_HUMAN
C:
[92-365]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
-------
Y
Q
K
Y
D
P
K
--
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
V
T
A
E
R
-----
L
SPEQ
L
--
E
E
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
A
G
-
H
P
H
I
I
T
L
I
D
S
Y
E
S
----
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
--
V
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
-
N
N
--
I
V
H
R
D
L
K
P
E
N
I
L
L
--
D
-
D
--
N
M
----
Q
-
I
R
L
S
D
F
G
F
S
C
H
L
E
P
G
E
---
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
-
K
CSMDETH
P
--
G
--
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
R
R
Q
------
I
L
M
L
R
M
I
M
E
G
-----------
Q
Y
Q
--
F
----------------------------------------------------------------------
S
S
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
-----
T
A
E
Q
A
L
Q
H
P
F
F
E
R
-
39
HHSearch
65.13
28%
-10
* C1 *
-
2PHK
2
PHKG1_RABIT
A:
[3-276]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
N
Y
E
P
K
--
E
I
L
G
R
G
V
S
S
V
V
R
R
C
I
H
K
P
T
C
K
E
Y
A
V
K
I
I
D
V
T
G
G
G
SFS
A
E
E
----
V
--
Q
E
L
R
E
A
T
L
K
E
V
D
I
L
R
K
V
-
S
G
H
P
N
I
I
Q
L
K
D
T
Y
E
T
----
N
T
F
F
F
L
V
F
D
L
M
K
K
G
E
L
F
D
Y
L
T
E
K
--
V
T
L
S
E
K
E
T
R
K
I
M
R
A
L
L
E
V
I
C
A
L
H
K
-
L
N
--
I
V
H
R
D
L
K
P
E
N
I
L
L
--
D
-
D
--
D
M
----
N
-
I
K
L
T
D
F
G
F
S
C
Q
L
D
P
G
E
---
K
L
R
E
V
C
G
T
P
S
Y
L
A
P
E
I
I
-
E
C
S
M
N
DNH
P
--
G
--
Y
G
K
E
V
D
M
W
S
T
G
V
I
M
Y
T
L
L
A
G
S
P
P
F
W
H
R
K
Q
------
M
L
M
L
R
M
I
M
S
G
-----------
N
Y
Q
---
F
---------------------------------------------------------------------
G
S
P
E
W
D
D
Y
S
D
T
V
K
D
L
V
S
R
F
L
V
V
Q
P
Q
K
R
Y
-----
T
A
E
E
A
L
A
H
P
F
F
Q
Q
-
32
HHSearch
65.09
25%
-2
- C1 -
-
2X0G
-
DAPK1_HUMAN
A:
[9-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-------
D
D
Y
Y
D
T
G
--
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
-----
S
SR--
R
--
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
-
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
----
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
--
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
-
L
Q
--
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
-
D
--
R
N
VP
K
P
R
-
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
N
---
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
-
N
Y------
E
--
P
--
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
------
Q
E
T
L
A
N
V
S
A
V
-----------
N
Y
E
---
F
--------------------------------------------------------------
E
-------
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
L
Q
H
P
W
I
K
P
-
40
HHSearch
64.94
25%
-5
- C1 -
-
4B4L
3
DAPK1_HUMAN
A:
[11-279]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-------
D
D
Y
Y
D
T
G
--
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
-----
S
SR--
R
--
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
-
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
----
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
--
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
-
L
Q
--
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
-
D
--
R
N
VP
K
P
R
-
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
---
N
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
-
N
Y------
E
--
P
--
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
------
Q
E
T
L
A
N
V
S
A
V
-----------
N
Y
E
-----------------------------------------------------------------
F
E
-------
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
L
Q
H
P
W
I
K
P
-
43
HHSearch
64.60
26%
-156
- C1 -
-
4JXF
2
PLK4_HUMAN
A:
[5-264]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-------
I
E
D
F
K
V
G
--
N
L
L
G
K
G
S
F
A
G
V
Y
R
A
E
S
I
H
T
G
L
E
V
A
I
K
M
I
D
K
K
A
M
Y
----------
K
--
A
G
M
V
Q
R
V
Q
N
E
V
K
I
H
C
Q
L
-
K
-
H
P
S
I
L
E
L
Y
N
Y
F
E
D
----
S
N
Y
V
Y
L
V
L
E
M
C
H
N
G
E
M
N
R
Y
L
K
N
R
V
-
K
P
F
S
E
N
E
A
R
H
F
M
H
Q
I
I
T
G
M
L
Y
L
H
S
-
H
G
--
I
L
H
R
D
L
T
L
S
N
L
L
L
--
T
-
R
--
N
M
----
N
-
I
K
I
A
D
F
G
L
A
T
Q
L
K
M
P
H
--
E
------------------------------------
S
D
V
W
S
L
G
C
M
F
Y
T
L
L
I
G
R
P
P
F
----
V
------
K
N
T
L
N
K
V
V
L
------------
A
D
Y
---------------------------------------------------------------------------
E
M
P
S
F
L
S
I
E
A
K
D
L
I
H
Q
L
L
R
R
N
P
A
D
R
L
-----
S
L
S
S
V
L
D
H
P
F
M
S
R
-
34
HHSearch
64.53
26%
-25
- C1 -
-
5O2C
4
WNK3_HUMAN
A:
[23-287]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-------
G
R
F
L
K
F
D
--
I
E
L
G
R
G
A
F
K
T
V
Y
K
G
L
D
T
E
T
W
V
E
V
A
W
C
E
L
Q
D
R
K
L
T
-------------
K
A
E
Q
Q
R
F
K
E
E
A
E
M
L
K
G
L
-
Q
-
H
P
N
I
V
R
F
Y
D
S
W
E
S
I
L
KG
K
K
C
I
V
L
V
T
E
L
M
T
S
G
T
L
K
T
Y
L
K
R
F
--
K
V
M
K
P
K
V
L
R
S
W
C
R
Q
I
L
K
G
L
Q
F
L
H
T
-
R
T
PP
I
I
H
R
D
L
K
C
D
N
I
F
I
--
T
G
P
--
T
G
----
S
-
V
K
I
G
D
L
G
L
A
T
L
M
R
T
S
----
F
A
K
S
V
I
G
T
P
E
F
M
A
P
E
M
Y
-
E
-------
E
--
H
--
Y
D
E
S
V
D
V
Y
A
F
G
M
C
M
L
E
M
A
T
S
E
Y
P
Y
S
E
C
Q
N
-----
A
A
Q
I
Y
R
K
V
T
S
G
-----------
I
K
P
--------------------------------------------------------------------------
A
S
F
N
K
V
T
D
P
E
V
K
E
I
I
E
G
C
I
R
Q
N
K
S
E
R
L
-----
S
I
R
D
L
L
N
H
A
F
F
A
E
-
21
HHSearch
64.49
25%
-78
- C1 -
-
2X4F
4
MYLK4_HUMAN
A:
[90-348]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
S
K
T
--
E
I
L
G
-----
Q
V
H
K
C
E
E
T
A
T
G
L
K
L
A
A
K
I
I
K
T
R
G
M
---------------
K
D
K
E
E
V
K
N
E
I
S
V
M
N
Q
L
-
D
-
H
A
N
L
I
Q
L
Y
D
A
F
E
S
----
K
N
D
I
V
L
V
M
E
Y
V
D
G
G
E
L
F
D
R
I
I
D
E
S
-
Y
N
L
T
E
L
D
T
I
L
F
M
K
Q
I
C
E
G
I
R
H
M
H
Q
-
M
Y
--
I
L
H
L
D
L
K
P
E
N
I
L
C
VN
R
-
D
--
A
K
----
Q
-
I
K
I
I
D
F
G
L
A
R
R
Y
K
P
R
E
---
K
L
K
V
N
F
G
T
P
E
F
L
A
P
E
V
V
-
N
Y------
D
--
F
--
V
S
F
P
T
D
M
W
S
V
G
V
I
A
Y
M
L
L
S
G
L
S
P
F
L
G
D
N
D
------
A
E
T
L
N
N
I
L
A
C
-----------
R
W
D
---
L
------------------------------------------------------------------
E
---
D
E
E
F
Q
D
I
S
E
E
A
K
E
F
I
S
K
L
L
I
K
E
K
S
W
R
I
-----
S
A
S
E
A
L
K
H
P
W
L
S
D
-
52
Fugue
64.47
16%
18
- C1 -
-
2ACX
1
GRK6_HUMAN
A:
[14-532]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
R
K
G
K
S
K
K
W
R
Q
M
L
Q
F
P
H
I
S
Q
C
E
E
L
R
L
S
L
E
R
D
Y
H
S
L
C
E
R
N
P
I
G
R
L
L
F
R
E
F
C
A
T
R
P
E
L
S
R
C
V
A
F
L
D
G
V
A
E
Y
E
V
T
P
D
D
K
R
K
A
C
G
R
N
L
T
Q
N
F
L
S
H
T
G
P
D
L
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
E
Q
G
P
C
K
D
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
QP
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
R
A
T
G
K
M
Y
A
C
K
K
L
E
K
K
R
I
K
-----
K
----
R
--
K
-
G
E
A
M
A
L
N
E
K
Q
I
L
E
K
V
-
N
-
S
R
F
V
V
S
L
A
Y
A
Y
E
T
----
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
M
G
Q
A
G
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
-
E
R
--
I
V
Y
R
D
L
K
P
E
N
I
L
L
--
D
-
D
--
H
G
----
H
-
I
R
I
S
D
L
G
L
A
V
H
V
P
E
G
Q
---
T
I
K
G
R
V
G
T
V
G
Y
M
A
P
E
V
V
-
K
-------
N
E
-
R
--
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
F
Q
Q
R
K
K
K
I
K
R
E
E
V
E
R
L
V
K
E
V
P
E
E
Y
S
E
R
-----
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
RLGCRGGS
A
R
E
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
GMLEPPFKPDP
Q
A
I
Y
C
E
P
T
D
Q
D
F
Y
Q
K
F
A
T
G
S
V
--
P
I
P
W
Q
N
E
M
V
E
T
--
E
C
F
Q
E
L
N
V
F
G
L
-----
D
G
S
-----------
22
HHSearch
64.15
25%
-80
- C1 -
-
1TKI
-
TITIN_HUMAN
A:
[21-280]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
K
Y
M
I
A
--
E
D
L
G
R
G
E
F
G
I
V
H
R
C
V
E
T
S
S
K
K
T
Y
M
A
K
F
V
K
V
K
G
T
----------------
D
Q
V
L
V
K
K
E
I
S
I
L
N
I
A
-
R
-
H
R
N
I
L
H
L
H
E
S
F
E
S
----
M
E
E
L
V
M
I
F
E
F
I
S
G
L
D
I
F
E
R
I
N
T
S
A
-
F
E
L
N
E
R
E
I
V
S
Y
V
H
Q
V
C
E
A
L
Q
F
L
H
S
-
H
N
--
I
G
H
F
D
I
R
P
E
N
I
I
Y
--
Q
-
T
RR
S
S
----
T
-
I
K
I
I
E
F
G
Q
A
R
Q
L
K
P
G
---
D
N
F
R
L
L
F
T
A
P
E
Y
Y
A
P
E
V
H
-
Q
H------
D
--
V
--
V
S
T
A
T
D
M
W
S
L
G
T
L
V
Y
V
L
L
S
G
I
N
P
F
L
A
E
T
N
------
Q
Q
I
I
E
N
I
M
N
A
-----------
E
Y
T
---
F
------------------------------------------------------------------
D
---
E
E
A
F
K
E
I
S
I
E
A
M
D
F
V
D
R
L
L
V
K
E
R
K
S
R
M
-----
T
A
S
E
A
L
Q
H
P
W
L
K
Q
-
42
HHSearch
63.72
24%
-67
- C1 -
-
2YEX
8
CHK1_HUMAN
A:
[5-267]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
-------
V
E
D
W
D
L
V
--
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
A
--------------
V
D
C
P
E
N
I
K
K
E
I
C
I
N
K
M
L
-
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
----
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
--
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
--
I
T
H
R
D
I
K
P
E
N
L
L
L
--
D
-
E
--
R
D
----
N
-
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
-
K
-------
R
RE
F
--
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
-----
S
C
Q
E
Y
S
D
W
K
E
K
------------
K
T
-----------------------------------------------------------------
Y
--------
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
N
K
-
18
PsiBlast_PDB
63.60
35%
-97
- C1 -
-
2XIK
2
STK25_HUMAN
A:
[27-228]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
K
G
S
F
G
E
V
Y
K
G
I
D
N
H
T
K
E
V
V
A
I
K
I
I
D
L
E
E
A
E
----------
E
--
I
E
D
I
Q
---
Q
E
I
T
V
L
S
Q
C
-
D
-
S
P
Y
I
T
R
Y
F
G
S
Y
L
K
----
S
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
K
P
G
P
---
L
E
E
T
Y
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
-
E
R
--
K
I
H
R
D
I
K
A
A
N
V
L
L
--
S
-
E
--
Q
G
----
D
-
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
--
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
Q
-------
S
--
A
--
Y
D
F
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
------
N
S
D
L
H
P
M
R
V
L
F
L
I
-----------------------------------------------------------------------------------------------------------------------------------------