@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_17_0550: (2018-03-09 )
MPLHKTRINADPQRSPPPAPANHIRSPVGSASSQSLAISPLSTKPVDIPSPERKPNSGVVTGVSISDGGAIWDRRAQCRAPTPPPSSITVERREEAGYGAMVAKGGKASSSLSKATAGRVGSQEDDVEGGDETSSEDEEDEEEDSDEEDDEGEEGGYYDGATSDQEEDDDVDTGDSTSDDEEDEDDASTSASSSSSGSSTAPVEIGSRRTRRKMQSGKKSTQRSLKAAKNTAVPSSASSGAQWCGGPGPAAQPIRTKVSREGDVNVKVIFAARSRHCFRRYVKEVMTRFGFRKATDFDMYCIDQYGDRVDIDTEEDFEQLLDAFTEAMGVVGKDSLVGSPDTHASPPPPSLEPLHHLYGANQSTGSCGMPAVGDGSSMSRHARERAMSFSASQNHTSSFYAAKSFSLSPRLDATIASSISAGSLVEDDGKSSGSVLRLYVRYSNAYYTEHRREFEQQMNHSLLYPQSMLSNGGSGAHPPPPPPQQQQLSLGSPSSKWRLQTDQLPSGHVSPGAVGSPLARNLLAFTTCSVGSGGGDGGAISSHDELNAVHGKSSDWAAASADSMSMQFNETLNSNLAKTLRLDEAEPLDWRRMSVLGKGSFGTVYEGITQDGKMLAVKVQELSLDDGEDAEAVKAVKAEINLMRSLKHKNIVTYYGCQTRVLPTGNQQMEVFLELCHGGSLASLRRKFVKAKEPFSISLVRSYTRQVLEGLAYLHAQNVVHRDIKSDNVLISAMGEAKLADFGCSKRLGPATLQGMPGTLPPGAAPAAAAPSPQEAAVARAAMHQTVVGSPFFMAPEVLREDGSYTGAADIWSVGCLVLELLGREPWDITGKNIFQIMFRISKEKGMPTGVPKKCPAILLDFFERCFQRDTKRRATAVELLEHEWLTCPDKALEEVPPSPLSQKESPAE
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.-......560.......570--.......580.....-----..590.......600.....-.-.610-........620....---.---..630.......640....-...650-.-......660.-..-....670.......680...-..--...690.......700.......710.......720.......730.-.---.....740.......750.......760.......770.......780.......790......--.----800----.----.......810.......820.-..-..--...830---.....-..840....--------------------------.-..--850....--...860.......870.--..-----....880....-...890....---....900.......-----------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MPLHKTRINADPQRSPPPA
P
A
N
H
I
RSPVGSASSQ
S
L
A
ISPLSTKPVDIPSPERKPNS
G
V
V
T
G
V
S
ISDGG
A
I
W
DRRAQCRAPTPPPSS
I
T
V
E
R
REEAGY
G
A
M
V
AKGGKASSSL
S
K
A
TAGRVGSQEDDVEGGDETSSEDEEDEEEDSDEEDDEGEEGGYYDGATSDQEEDDDVDTGDSTSDDEEDEDDASTSASSSSSGSSTA
P
V
EIG
S
R
R
T
R
R
K
M
Q
SG
K
K
S
T
Q
R
S
L
K
A
AKNTAVPSSASSGAQWCGGPGPAAQ
P
I
R
T
K
VSREGD
V
N
V
K
V
I
F
AARS
R
H
C
F
R
R
Y
V
K
E
V
M
T
R
FGFRKATDF
D
M
Y
C
I
D
QYGDRVDID
T
E
E
D
F
E
Q
L
L
D
A
F
T
E
A
M
GVVGKDSLVGSPDTHASPPPPS
L
E
P
L
H
H
L
YGANQSTGSCGMPAVGDG
S
S
M
S
R
H
A
R
E
R
A
MSFSASQNHTS
S
F
Y
A
AKSFSLSPRL
D
A
T
I
A
SSISAGSLVEDDGKSSG
S
V
L
R
L
Y
V
R
YSN
A
Y
Y
T
E
H
R
R
E
F
E
Q
QMNHSLLY
P
Q
S
M
LSNGGSGAHPPPPP
P
Q
Q
QQLSLGSPSS
K
W
R
L
QTDQLPSGHVSPGAV
G
S
P
L
A
R
N
L
L
A
F
T
T
C
SVGSGGGDGGAISSHDE
L
N
AVHGKS-SDWAAASADS
M
S
M
Q
F
N
E
T
L
--
N
S
N
L
A
K
T
LRLDEAEP-----L
D
W
R
R
M
S
VLGKGS
F
G
T
V
Y
EG-I-TQ-D-G
K
M
L
A
V
K
V
Q
E
LSLDD---G---E
D
A
E
A
V
K
A
V
K
A
E
I
N
L
M
R
S
L
-KHK
N
I
V
-
T
-
Y
YGC
Q
T
R
V
LP-TG-
N
Q
Q
M
E
V
F
L
E
L
CHGG
S
L
-
A
S
L
-
R
R
--
K
F
V
KAKEPF
S
I
S
L
V
R
S
Y
T
R
Q
V
L
E
G
L
A
Y
L
H
A
Q
N
V
V
H
R
DIKSD
N
V
L
I
S
A-M---GE
A
K
L
ADFGCSKRLGPATLQGMPGTLPPGAAPAAAAP
S
P
Q
E
A
A
V
A
R
A
A
M
H
Q
TVVGS
P
F
FM
A
P
E
V
--
L
----RE-----D----GSYTG
A
A
D
I
W
S
V
G
C
L
V
L
E
L
-L-GR-EP--WDI
T
G
K
---
N
I
F
Q
I
-
M
F
R
I
S
KEKG--------------------------M-PT--GVPKK
C
P
--
A
I
L
L
D
F
F
E
R
C
F
Q
RDTKR--
R
A
-----
T
A
V
E
L
L
E
H
EWL-TC
P
D
-
K
A
L
E
E---VPPSPLSQKESPAE-----------------------------------------------
53
Fugue
72.48
18%
0
- C1 -
-
3C4Z
1
RK_BOVIN
A:
[31-533]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
C
E
A
L
R
E
S
L
D
L
G
F
E
G
M
C
L
E
Q
-
P
I
G
K
R
L
F
Q
Q
F
L
R
T
H
E
Q
H
G
P
A
L
Q
L
W
K
D
I
E
D
Y
D
T
A
D
D
A
------------
L
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
E
P
Q
A
Q
L
F
C
S
F
L
D
A
E
T
V
A
R
A
R
A
G
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
QPMGE
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
-
Q
-
M
K
-
A
T
G
K
L
Y
A
C
K
K
--
L
N
K
K
R
---
L
---
K
K
R
K
G
Y
Q
G
A
M
V
E
K
K
I
L
A
K
V
-
H
S
R
F
I
V
S
L
-
A
Y
A
F
E
T
K
--------
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
-
R
Y
H
-
I
Y
--
N
V
D
E
D
N
P
G
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
R
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
-
D
---
G
N
V
R
I
S
D
L
G
L
A
V
E
L
K
A
-----------------------------
G
Q
T
K
T
K
G
Y
A
G
T
P
G
F
M
A
P
E
L
--
L
----
L
G
-----
E
-----
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
-
I
A
A
R
-
G
P
--
F
R
A
R
G
E
---
K
V
E
N
K
-
E
L
K
Q
R
V
L
E
Q
----------------------------
A
V
--
T
Y
P
D
K
F
S
--
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
--
R
L
GFRDG
S
C
D
G
L
R
T
H
P
L
F
R
D
I
S
W
-
R
Q
L
E
A
GML
T
P
P
F
V
P
D
S
R
T
V
Y
A
K
NGAFSG
V
A
F
E
K
A
D
T
E
F
F
Q
E
F
A
SGTC
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
VWRP
30
HHSearch
69.96
33%
-31
- C1 -
-
5J5T
1
M4K3_HUMAN
A:
[4-267]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
F
E
L
I
Q
R
I
G
S
G
T
Y
G
D
V
Y
K
A
-
R
-
N
V
N
T
-
G
E
L
A
A
I
K
V
I
K
L
E
P
G
-----------
E
D
F
A
V
V
Q
Q
E
I
I
M
M
K
D
C
-
K
H
P
N
I
V
-
A
-
Y
F
G
S
Y
L
R
R
-------
D
K
L
W
I
C
M
E
F
C
G
G
G
S
L
-
Q
D
I
-
Y
H
--
V
T
G
----
P
L
S
E
L
Q
I
A
Y
V
S
R
E
T
L
Q
G
L
Y
Y
L
H
S
K
G
K
M
H
R
D
I
K
G
A
N
I
L
L
T
D
-
N
---
G
H
V
K
L
A
D
F
G
V
S
A
Q
I
T
A
T
I
-----------------------------
A
---
A
F
I
G
T
P
Y
W
M
A
P
E
V
--
A
----
A
V
ER---
K
----
G
G
Y
N
Q
L
C
D
L
W
A
V
G
I
T
A
I
E
L
-
A
-
E
L
Q
P
P
--
M
F
-
D
L
----
H
P
M
R
A
-
L
F
L
M
T
K
S
N
F
--------------------------
Q
-
P
P
KL
K
D
K
M
K
W
S
--
N
S
F
H
H
F
V
K
M
A
L
T
K
N
P
K
K
--
R
P
-----
T
A
E
K
L
L
Q
H
P
F
V
-
T
Q
------------------------------------------------------------------------
22
HHSearch
69.10
29%
-28
- C1 -
-
3C0G
1
CSKP_HUMAN
B:
[24-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
-
I
-
N
R
E
T
-
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
---
S
---
S
P
G
L
S
T
E
D
L
K
R
E
A
S
I
C
H
M
L
-
K
H
P
H
I
V
-
E
-
L
L
E
T
Y
S
S
D
-------
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
-
C
F
E
-
I
V
--
K
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
-
K
ENS
A
P
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
S
G
-----------------------------
L
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
--
V
----
K
R
-----
E
-----
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
-
L
-
S
G
C
L
P
--
F
Y
G
T
K
E
------
R
L
-
F
E
G
I
I
K
G
K
Y
K-------------------------
M
-
N
P
--
R
Q
W
S
H
I
S
--
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
--
R
I
-----
T
V
Y
E
A
L
N
H
P
W
L
-
K
E
R
D
-
R
--------------------------------------------------------------------
20
PsiBlast_PDB
68.71
28%
-22
- C1 -
-
1YHW
-
PAK1_HUMAN
A:
[270-540]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
-
M
D
V
A
-
T
-
G
Q
E
V
A
I
R
--
Q
M
N
L
Q
Q
---
Q
---
P
K
K
E
L
I
I
N
---
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
-
N
-
Y
L
D
S
Y
L
-----
V
G
-
D
E
-
L
W
V
V
M
E
Y
L
A
G
G
S
L
-
T
D
--------
V
V
T
E
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
-
D
---
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
-----------------------------
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
--
V
----
T
R
-----
K
-----
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
-
I
-
E
G
-
E
P
---
P
Y
L
N
E
---
N
P
L
R
A
-
L
Y
L
I
A
T
N
G
T
--------------------------
P
-
E
L
--
Q
N
P
E
K
L
S
--
A
I
F
R
D
F
L
N
R
C
L
D
M
D
V
E
K
--
R
G
-----
S
A
K
E
L
L
Q
H
Q
F
L
-
K
I
A
--
K
P
L
S
S
---
L
T
P
L
I
A
A
A
K
E
A
--------------------------------------------------
37
HHSearch
67.77
26%
-28
- C1 -
-
1J1B
1
GSK3B_HUMAN
B:
[54-344]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
-
K
-
L
C
D
S
-
G
E
L
V
A
I
K
K
V
L
Q
D
K
---------------
R
F
K
N
R
E
L
Q
I
M
R
K
L
-
D
H
C
N
I
V
-
R
-
L
R
Y
F
F
Y
S
S
G
E
K
K
D
-
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
-
R
V
A
-
R
H
---
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
---
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
------------------------------
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
--
I
----
F
G
-----
A
----
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
-
L
-
L
G
Q
P
I
--
F
P
G
D
-----
S
G
V
D
Q
-
L
V
E
I
I
K
V
L
G
TPT
R
E
Q
I
R
E
M
NPNYTEFKFPQIKAHP
W
-
T
K
--
V
F
R
P
R
T
P
--
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
--
R
L
-----
T
P
L
E
A
C
A
H
S
F
F
-
D
E
L
R
----------------------------------------------------------------------
24
HHSearch
67.74
26%
-24
- C1 -
-
2Y7J
1
PHKG2_HUMAN
D:
[93-365]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-----
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
-
V
-
H
R
A
T
-
G
H
E
F
A
V
K
I
M
E
V
---
R
LSP
E
---
Q
L
E
E
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
-
T
-
L
I
D
S
Y
E
S
S
-------
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
-
F
D
Y
-
L
T
--
E
K
V
----
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
D
D
-
N
---
M
Q
I
R
L
S
D
F
G
F
S
C
H
L
E
P
G
E
------------------------------
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
--
L
----
K
C
SMDET
H
----
P
G
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
-
L
-
A
G
S
P
P
--
F
W
H
R
-----
R
Q
I
L
M
-
L
R
M
I
M
E
G
Q
Y
--------------------------
Q
F
S
S
--
P
E
W
D
D
R
S
--
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
--
R
L
-----
T
A
E
Q
A
L
Q
H
P
F
F
-
E
R
------------------------------------------------------------------------
21
HHSearch
67.65
29%
-24
- C1 -
-
3C0I
1
CSKP_HUMAN
A:
[24-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
-
I
-
N
R
E
T
-
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
---
S
---
S
P
G
L
S
T
E
D
L
K
R
E
A
S
I
C
H
M
L
-
K
H
P
H
I
V
-
E
-
L
L
E
T
Y
S
S
D
-------
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
-
C
F
E
-
I
V
--
K
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
-
K
ENS
A
P
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
S
G
-----------------------------
L
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
--
V
----
K
R
-----
E
-----
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
-
L
-
S
G
C
L
P
--
F
Y
G
T
K
E
------
R
L
-
F
E
G
I
I
K
G
K
Y
K
-------------------------
M
-
N
P
--
R
Q
W
S
H
I
S
--
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
--
R
I
-----
T
V
Y
E
A
L
N
H
P
W
L
-
K
E
R
D
-
R
--------------------------------------------------------------------
11
PsiBlast_PDB
66.41
28%
-24
- C1 -
-
4ZJI
1
PAK1_HUMAN
A:
[24-294]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
-
M
D
V
A
-
T
-
G
Q
E
V
A
I
K
--
Q
M
N
L
-----------
K
E
L
I
I
N
---
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
-
N
-
Y
L
D
S
Y
L
-----
V
G
-
D
E
-
L
W
V
V
M
E
Y
L
A
G
G
S
L
-
T
D
--------
V
V
T
E
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
-
D
---
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
-----------------------------------
T
M
V
G
T
P
Y
W
M
A
P
E
V
--
V
----
T
R
-----
K
-----
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
-
I
-
E
G
-
E
P
---
P
Y
L
N
E
---
N
P
L
R
A
-
L
Y
L
I
A
T
N
G
T
--------------------------
P
-
E
L
--
Q
N
P
E
K
L
S
--
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
--
R
G
-----
S
A
K
E
L
L
Q
H
Q
F
L
-
K
I
A
--
K
P
L
S
S
---
L
T
P
L
I
A
A
A
K
E
A
--------------------------------------------------
13
PsiBlast_PDB
65.66
28%
-21
- C1 -
-
5AX9
1
TNIK_HUMAN
A:
[22-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
L
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
-
V
K
-
T
-
G
Q
L
A
A
I
K
V
M
D
V
T
G
D
E
---
E
---
E
E
------
I
K
Q
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
-
T
-
Y
Y
G
A
F
I
K
K
N
P
-
P
G
M
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
V
-
T
D
L
-
I
K
N
T
K
G
N
T
L
K
E
E
W
----
I
A
Y
I
C
R
E
I
L
R
G
L
S
H
L
H
Q
H
K
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
-
N
---
A
E
V
K
L
V
D
F
G
V
S
-------------------------------------------
G
T
P
Y
W
M
A
P
E
V
--
I
ACDE
N
P
-----
D
----
A
T
Y
D
F
K
S
D
L
W
S
L
G
I
T
A
I
E
M
-
A
-
E
G
-
A
P
---
P
L
C
D
M
---
H
P
M
R
A
-
L
F
L
I
P
R
N
P
A
----------------------------
P
R
--
L
K
S
K
K
W
S
--
K
K
F
Q
S
F
I
E
S
C
L
V
K
N
H
S
Q
--
R
P
-----
A
T
E
Q
L
M
K
H
P
F
I
---------------------------------------------------------------------------
15
PsiBlast_PDB
64.90
28%
-27
- C1 -
-
5D7A
1
TNIK_HUMAN
A:
[22-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
L
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
-
V
K
-
T
-
G
Q
L
A
A
I
K
V
M
D
V
T
G
D
E
---
E
---
E
E
------
I
K
Q
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
-
T
-
Y
Y
G
A
F
I
K
K
N
P
-
P
G
M
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
V
-
T
D
L
-
I
K
N
T
K
G
N
T
L
K
E
E
W
----
I
A
Y
I
C
R
E
I
L
R
G
L
S
H
L
H
Q
H
K
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
-
N
---
A
E
V
K
L
V
D
F
G
V
----------------------------------------
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
--
I
ACDE
N
P
-----
D
----
A
T
Y
D
F
K
S
D
L
W
S
L
G
I
T
A
I
E
M
-
A
-
E
G
-
A
P
---
P
L
C
D
M
---
H
P
M
R
A
-
L
F
L
I
P
R
N
P
A
----------------------------
P
R
--
L
K
S
K
K
W
S
--
K
K
F
Q
S
F
I
E
S
C
L
V
K
N
H
S
Q
--
R
P
-----
A
T
E
Q
L
M
K
H
P
F
I
---------------------------------------------------------------------------
12
PsiBlast_PDB
64.90
28%
-27
- C1 -
-
4ZJJ
1
PAK1_HUMAN
A:
[24-293]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
-
M
D
V
A
-
T
-
G
Q
E
V
A
I
K
--
Q
M
N
L
Q
----------
K
E
L
I
I
N
---
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
-
N
-
Y
L
D
S
Y
L
-----
V
G
-
D
E
-
L
W
V
V
M
E
Y
L
A
G
G
S
L
-
T
D
--------
V
V
T
E
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
-
D
---
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
------------------------------------
T
M
V
G
T
P
Y
W
M
A
P
E
V
--
V
----
T
R
-----
K
-----
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
-
I
-
E
G
-
E
P
---
P
Y
L
N
E
---
N
P
L
R
A
-
L
Y
L
I
A
T
N
G
T
--------------------------
P
-
E
L
--
Q
N
P
E
K
L
S
--
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
--
R
G
-----
S
A
K
E
L
L
Q
H
Q
F
L
-
K
I
A
--
K
P
L
S
S
---
L
T
P
L
I
A
A
A
K
E
---------------------------------------------------
8
PsiBlast_PDB
64.78
34%
-22
- C1 -
-
5UOR
1
M3K5_HUMAN
A:
[16-269]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
K
G
T
Y
G
I
V
Y
A
G
-
R
-
D
L
-
S
-
N
Q
-
V
R
I
A
I
K
E
I
P
------
E
---
R
D
S
R
Y
S
Q
P
L
H
E
E
I
A
L
H
K
H
L
-
K
H
K
N
I
V
-
Q
-
Y
L
G
S
F
S
E
-------
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
-
S
A
L
L
R
S
--
K
W
G
P
L
K
D
--
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
-
Y
S--
G
V
L
K
I
S
D
F
G
T
S
K
R
L
--------------------------------------
F
T
G
T
L
Q
Y
M
A
P
E
I
--
I
D-----------------
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
-
G
K
-
P
P
--
F
Y
E
------
A
M
F
K
V
G
M
F
K
V
H
P
E
-----------------------------------
I
P
E
S
M
S
--
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
--
R
A
-----
C
A
N
D
L
L
V
D
E
F
L
---------------------------------------------------------------------------
9
PsiBlast_PDB
63.91
28%
-34
- C1 -
-
5J5T
1
M4K3_HUMAN
A:
[5-266]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
E
L
I
Q
R
I
G
S
G
T
Y
G
D
V
Y
K
A
-
R
-
N
V
-
N
T
G
E
L
A
A
I
K
V
--
I
K
L
E
P
---
G
---
E
D
---
F
A
V
V
Q
Q
E
I
I
M
M
K
D
C
-
K
H
P
N
I
V
-
A
-
Y
F
G
S
Y
L
R
-------
R
D
K
L
W
I
C
M
E
F
C
G
G
G
S
L
-
Q
D
I
-
Y
H
------
V
T
G
P
L
S
E
L
Q
I
A
Y
V
S
R
E
T
L
Q
G
L
Y
Y
L
H
S
K
G
K
M
H
R
D
I
K
G
A
N
I
L
L
T
D
-
N
---
G
H
V
K
L
A
D
F
G
V
S
A
Q
I
-----------------------------
T
A
T
I
A
---
A
F
I
G
T
P
Y
W
M
A
P
E
V
A
A
V
----
E
R
-----
K
----
G
G
Y
N
Q
L
C
D
L
W
A
V
G
I
T
A
I
E
L
-
A
-
E
L
-
Q
P
PM
F
D
L
------
H
P
M
R
A
-
L
F
L
M
T
K
S
N
F
--------------------------
Q
-
P
P
--
K
L
K
D
K
M
K
W
S
N
S
F
H
H
F
V
K
M
A
L
T
K
N
P
K
K
--
R
P
-----
T
A
E
K
L
L
Q
H
P
F
V
-
T
-------------------------------------------------------------------------
1
PsiBlast_PDB
62.84
33%
-13
- C1 -
-
2CLQ
1
M3K5_HUMAN
A:
[29-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
K
G
T
Y
G
I
V
Y
A
G
-
R
-
D
L
-
S
-
N
Q
-
V
R
I
A
I
K
E
I
P
------
E
---
R
D
S
---
Q
P
L
H
E
E
I
A
L
H
K
H
L
-
K
H
K
N
I
V
-
Q
-
Y
L
G
S
F
S
E
-------
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
-
R
S
--
K
W
G
P
L
K
D
--
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
-
Y
S--
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
-------------
G
---------------------
E
T
F
T
G
T
L
Q
Y
M
A
P
E
I
--
I
----
D
K
-----
G
P---
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
-
G
K
-
P
P
--
F
Y
E
L
G
E
P
Q
A
A
M
F
K
V
G
M
F
K
V
H
P
E
-----------------------------------
I
P
E
S
M
S
--
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
--
R
A
-----
C
A
N
D
L
L
V
D
E
F
L
-
K
V
------------------------------------------------------------------------
23
HHSearch
62.78
26%
-26
- C1 -
-
2Y7J
1
PHKG2_HUMAN
C:
[93-365]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-----
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
-
V
-
H
R
A
T
-
G
H
E
F
A
V
K
I
M
E
V
T
A
E
R
---
L
SPE
Q
L
E
E
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
-
T
-
L
I
D
S
Y
E
S
S
-------
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
-
F
D
Y
-
L
T
--
E
K
V
----
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
D
D
-
N
---
M
Q
I
R
L
S
D
F
G
F
S
C
H
L
E
P
G
E
------------------------------
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
--
L
----
K
C
SMDET
H
----
P
G
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
-
L
-
A
G
S
P
P
--
F
W
H
R
-----
R
Q
I
L
M
-
L
R
M
I
M
E
G
Q
Y
--------------------------
Q
F
S
S
--
P
E
W
D
D
R
S
--
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
--
R
L
-----
T
A
E
Q
A
L
Q
H
P
F
F
-
E
R
------------------------------------------------------------------------
4
PsiBlast_PDB
61.93
34%
-20
- C1 -
-
4BIC
2
M3K5_HUMAN
A:
[26-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
K
G
T
Y
G
I
V
Y
A
G
-
R
-
D
L
-
S
-
N
Q
V
-
R
I
A
I
K
E
I
P
------
E
--------
S
Q
P
L
H
E
E
I
A
L
H
K
H
L
-
K
H
K
N
I
V
-
Q
-
Y
L
G
S
F
S
E
-------
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
-
R
S
--
K
W
G
P
L
K
D
--
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
-
Y
S--
G
V
L
K
I
S
D
F
G
T
S
K
R
L
------------------
A
G
------
E
-----------
F
T
G
T
L
Q
Y
M
A
P
E
I
--
I
D
---
K
G
-----
P
----
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
-
G
K
-
P
P
--
F
Y
E
L
G
E
P
Q
A
A
M
F
K
V
G
M
F
K
V
H
P
E
-----------------------------------
I
P
E
S
M
S
--
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
--
R
A
-----
C
A
N
D
L
L
V
D
E
F
L
-
K
V
------------------------------------------------------------------------
57
Fugue
61.89
22%
11
- C1 -
-
4AW2
5
MRCKA_RAT
A:
[1-416]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
E
V
R
L
R
Q
L
E
Q
F
I
L
D
G
P
A
Q
T
N
G
Q
C
F
S
V
E
T
L
L
D
I
L
I
C
L
-
Y
D
E
C
N
N
S
P
L
R
R
E
K
N
I
L
E
Y
L
--
E
W
A
K
P
F
T
S
K
V
K
Q
M
R
L
HR---
E
D
F
E
I
L
K
V
I
G
R
G
A
F
G
E
V
A
V
V
-
K
-
L
K
-
N
A
D
K
V
F
A
M
K
I
--
L
N
K
W
E
---
M
---
L
K
R
A
E
T
A
C
F
R
E
E
R
D
V
L
V
N
G
-
D
S
K
W
I
T
-
T
L
H
Y
A
F
Q
D
--------
D
N
N
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
-
L
T
L
-
L
S
--
K
F
---
E
D
R
L
P
E
E
M
A
R
F
Y
L
A
E
M
V
I
A
I
D
S
V
H
Q
L
H
Y
V
H
R
D
I
K
P
D
N
I
L
M
D
M
-
N
---
G
H
I
R
L
A
D
F
G
S
C
L
K
L
M
E
------
D
G
T
V
Q
S
S
V
A
----------------------
V
G
T
P
D
Y
I
S
P
E
I
--
L
----
Q
A
-----
M
E
GGK
G
R
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
-
L
Y
G
E
-
T
P
--
F
Y
A
E
S
L
---
V
E
T
Y
G
-
K
I
M
N
H
K
E
R
F
--------------------------
Q
-
F
P
--
T
Q
V
T
D
V
S
--
E
N
A
K
D
L
I
R
R
L
I
C
S
R
E
H
R
LG
Q
N
-----
G
I
E
D
F
K
K
H
P
F
F
-
S
G
I
D
W
D
N
I
R
N
---
C
E
A
P
Y
I
P
E
V
S
S
P
T
D
TSNFDVDSGHHLPFVGF
T
Y
T
S
SCVLSDRSCLR---------------
16
PsiBlast_PDB
60.98
28%
-20
- C1 -
-
4ZY4
1
PAK1_HUMAN
A:
[23-293]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
-
M
D
V
A
-
T
-
G
Q
E
V
A
I
K
-------
Q
---
Q
---
P
K
K
E
L
I
I
N
---
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
-
N
-
Y
L
D
S
Y
L
-----
V
G
-
D
E
-
L
W
V
V
M
E
Y
L
A
G
G
S
L
-
T
D
--------
V
V
T
E
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
-
D
---
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
-----------------------------
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
--
V
----
T
R
-----
K
-----
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
-
I
-
E
G
-
E
P
---
P
Y
L
N
E
---
N
P
L
R
A
-
L
Y
L
I
A
T
N
G
T
--------------------------
P
-
E
L
--
Q
N
P
E
K
L
S
--
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
--
R
G
-----
S
A
K
E
L
L
Q
H
Q
F
L
-
K
I
A
--
K
P
L
S
S
---
L
T
P
L
I
A
A
A
K
E
A
--------------------------------------------------
48
HHSearch
60.95
27%
-26
- C1 -
-
5K00
1
MELK_HUMAN
A:
[7-266]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-----
K
Y
Y
E
L
H
E
T
I
G
T
G
--
A
K
V
K
L
A
-
C
-
H
I
L
T
-
G
E
M
V
A
I
K
I
M
D
K
N
T
L
----------
G
S
D
L
P
R
I
K
T
E
I
E
A
L
K
N
L
-
R
H
Q
H
I
C
-
Q
-
L
Y
H
V
L
E
T
A
-------
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
-
F
D
Y
-
I
I
--
S
Q
----
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
-
Y
---
H
K
L
K
L
I
D
F
G
L
C
A
K
P
-----------------------------------------
S
L
A
Y
A
A
P
E
L
--
I
----
Q
G
-----
K
----
S
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
-
M
-
C
G
F
L
P
--
F
D
--
D
D
---
N
V
M
A
L
-
Y
K
K
I
M
R
G
------------------------------
K
Y
--
D
V
P
K
W
L
S
--
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
--
R
I
-----
S
M
K
N
L
L
N
H
P
W
I
-
M
Q
D
Y
----------------------------------------------------------------------
7
PsiBlast_PDB
60.90
34%
-27
- C1 -
-
5V24
1
M3K5_HUMAN
A:
[16-269]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
K
G
T
Y
G
I
V
Y
A
G
-
R
-
D
L
-
S
-
N
Q
-
V
R
I
A
I
K
E
I
P
------
E
---
R
D
S
----
P
L
H
E
E
I
A
L
H
K
H
L
-
K
H
K
N
I
V
-
Q
-
Y
L
G
S
F
S
E
-------
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
-
S
A
L
L
R
S
--
K
W
G
P
L
K
D
--
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
-
Y
S--
G
V
L
K
I
S
D
F
G
T
S
K
R
L
--------------------------------------
F
T
G
T
L
Q
Y
M
A
P
E
I
--
I
D-----------------
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
-
G
K
-
P
P
--
F
Y
E
--
E
P
Q
A
A
M
F
K
V
G
M
F
K
V
H
P
E
-----------------------------------
I
P
E
S
M
S
--
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
--
R
A
-----
C
A
N
D
L
L
V
D
E
F
L
---------------------------------------------------------------------------