@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_19_0130: (2018-03-09 )
MQPSSDNGASTGANVVVEGKYTIQDANIVGRGAYSVVKVCTPIHPYVPPGSRPGMKYVVKIIEKEYLISLAKGDVDMAMAEIKREIDVLRHIPSHENVVTFLEYVETEKQFLLFFEKVQCGDLCELILQSSSGKLTEEKSKLYTYQIIKAVLHCHLHDIIHRDIKPENLLVSEDDNIKLTDFGLAKRSRGVCTGDSPRDPLDVTALMMPYPGCERLLGKRVVCSDVIGTPRYGAPEMFYAKFTQTHYDGFNADTWSIGVVTYITLSGSFPYSPGSNASEKEVFRTIMSTPLPKPSGISPLAWEFVQSMLNKDPSKRTPLYAALNHPWLADVVVQRGSVVAAQLRASVISADVESAAARFDEEARRLRICMAKLQSEVAALREERDRVREVQQPALQETHTQARRAQTPSGLSRPRSTRYPASTIRVSSPARVTNHRRTGSRDSSSAGSVPRRASAPRGRSPLARSAGGAAVRRGTPARAGGTTPARSATPSRTTGARSGSAARAMISTRGATPTRSATPGRSAHDRSRTPHRSAISGTSNGTTSGVSHSTNAVNPANELHLGDQVTYKGCRAIVRFNGSTAFGAGIWIGLEMLEGNEGTNDGSSFIDKKQYFTCPKGKGVFVRASQVKKLG
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120..-.....130...-....140.......150.......160.......170-...---.----.---...180.......190.......200.......210.......220.......230.......240.-.....--.250.......260.......270.......280.......----290--..----..--.....300.......310.......320.......330----........340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MQPSSDNGASTG
A
N
V
V
V
E
G
K
Y
T
I
QDA
N
I
VG
R
G
A
Y
S
V
V
K
V
CTPIHPYVPPGSR
P
G
M
K
Y
V
V
K
I
I
E
K
E
Y
L
I
S
LAKG
D
V
D
M
A
M
A
E
I
K
R
E
I
D
V
L
R
HIPS
H
E
N
V
V
T
F
L
E
Y
V
E
T
E
K
Q
F
L
L
F
F
EKVQ
C
G
D
L
C
-
E
L
I
L
QSSSGKL-
T
E
E
K
SK
L
Y
T
Y
Q
I
I
K
A
V
L
H
C
H
L
H
D
I
I
H
RDIKPE
N
L
L
V--SED---D----
N
---
I
K
L
TDFGLAKRSRGVCTGDSPRDPL
D
V
T
A
LMMPYP
G
C
E
R
L
LGK
R
V
V
C
S
DVIGTPRYGA
P
E
M
F
Y
A
K
F
T
-
Q
T
HYD--GFNA
D
T
W
S
I
G
V
V
T
Y
I
T
LSGSFPYSPGSN
A
S
E
K
E
V
F
R
T
I
M
ST----P----LP----KP--SGI
S
P
L
A
W
E
F
V
Q
S
M
L
NKDPSKRT
P
L
Y
A
ALNH
P
W
L
A
D
V
-----
V
V
QRG
S
V
V
A
A
Q
L
R
A
S
V
I
S
A
D
V
E
S
A
A
A
R
F
D
E
E
A
R
R
L
R
I
C
M
A
K
L
Q
S
E
V
A
A
L
R
E
E
R
D
R
V
R
E
V
Q
Q
P
A
L
Q
E
T
H
T
Q
A
RRAQTPSGLSRPRSTRYPA
S
T
I
R
VSSPARVTNHRRTGSRDSSSAGSVPRRASAPRGRSPLARSAGGAAVRRGTPARAGGTTPARSATPSRTTGARSGS
A
A
R
A
M
I
STRGATPTRSATPGRSAHDRSRTPHRSAISGTSNGTTSGVSHSTNAVNP
A
N
ELHLGDQ
V
T
Y
K
G
C
R
A
I
V
R
FNGSTAFG
A
G
I
W
I
G
L
E
M
LEGNEGTND
G
S
S
FIDKK
Q
Y
F
TCPKG
K
G
V
F
V
R
A
S
Q
V
KKLG
41
HHSearch
81.78
33%
0
- C- -
-
2WEL
7
KCC2D_HUMAN
A:
[2-271]
----------------
M
T
D
E
Y
Q
L
F
--
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
--------
T
G
Q
E
Y
A
A
K
I
I
N
T
K
K
L
S
-------
A
R
D
H
Q
K
L
E
R
E
A
R
I
C
R
L
L
-
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
-
E
D
I
V
A
R
--
E
Y
Y
-
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
--
A
S
K
SKG
A
----
A
---
V
K
L
A
D
F
G
L
A
I
E
V
Q
G
D
----------------------------
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
D
------
P
Y
--
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
H
---
R
L
Y
Q
Q
I
K
A
G
AYDF
P
----
S
P
----
E
W
--
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
C
Q
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
80.54
29%
-40
- C1 -
-
2YAB
1
DAPK2_MOUSE
A:
[4-295]
----------
T
F
K
Q
Q
K
V
E
D
F
Y
D
I
G
E
E
--
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
--------
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
Q
S
R
A
S
R
R
G
---
V
C
R
E
E
I
E
R
E
V
S
I
L
R
Q
V
L
-
H
P
N
I
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
-
D
F
L
A
Q
K
E
S
--
L
-
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
K
---
N
IP
I
P
H
---
I
K
L
I
D
F
G
L
A
H
E
I
E
D
---------------------
G
V
E
--------
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
--------
V
N
Y
E
PL
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-
L
G
D
T
K
Q
E
T
L
A
N
I
T
A
V
S
Y
----
D
----
F
D
----
E
E
FF
S
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
T
P
V
D
T
Q
Q
A
M
V
R
R
E
S
V
V
N
L
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
HHSearch
80.39
33%
-56
* C1 *
-
2X0G
-
DAPK1_HUMAN
A:
[8-280]
---------------
N
V
D
D
Y
Y
D
T
G
--
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
--------
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
---
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
-
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
-
D
F
L
A
E
K
--
E
S
L
-
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
R
---
N
VP
K
P
R
---
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
-----------------------------
N
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
------
P
L
--
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
---
T
L
A
N
V
S
A
V
NYEF
E
----
D
E
----
Y
F
--
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
-----
D
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
79.09
29%
-39
- C1 -
-
2YA9
2
DAPK2_MOUSE
A:
[4-295]
----------
T
F
K
Q
Q
K
V
E
D
F
Y
D
I
G
E
E
--
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
--------
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
Q
S
R
A
S
R
R
G
---
V
C
R
E
E
I
E
R
E
V
S
I
L
R
Q
V
L
-
H
P
N
I
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
-
D
F
L
A
Q
K
E
S
--
L
-
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
K
---
N
IP
I
P
H
---
I
K
L
I
D
F
G
L
A
H
E
I
E
D
---------------------
G
V
E
--------
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
--------
V
N
Y
E
PL
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-
L
G
D
T
K
Q
E
T
L
A
N
I
T
A
V
S
Y
----
D
----
F
D
----
E
E
FF
S
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
T
P
V
D
T
Q
Q
A
M
V
R
R
E
S
V
V
N
L
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
78.76
30%
-39
- C1 -
-
1WMK
-
DAPK2_HUMAN
A:
[9-294]
----------------
V
E
D
F
Y
D
I
G
E
E
--
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
--------
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
Q
S
R
A
S
R
R
G
---
V
S
R
E
E
I
E
R
E
V
S
I
L
R
Q
V
L
H
H
-
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
-
D
F
L
A
Q
K
E
S
--
L
-
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
K
---
N
IP
I
P
H
---
I
K
L
I
D
F
G
L
A
H
E
I
E
D
---------------------
G
V
E
--------
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
--------
V
N
Y
E
PL
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-
L
G
D
T
K
Q
E
T
L
A
N
I
T
A
V
S
Y
----
D
----
F
D
----
E
E
FF
S
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
T
P
V
D
N
Q
Q
A
M
V
R
R
E
S
V
V
N
L
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
78.61
29%
-40
- C1 -
-
2YAA
1
DAPK2_MOUSE
A:
[3-295]
---------
E
T
F
K
Q
Q
K
V
E
D
F
Y
D
I
G
E
E
--
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
--------
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
Q
S
R
A
S
R
R
G
---
V
C
R
E
E
I
E
R
E
V
S
I
L
R
Q
V
L
-
H
P
N
I
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
-
D
F
L
A
Q
K
E
S
--
L
-
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
K
---
N
IP
I
P
H
---
I
K
L
I
D
F
G
L
A
H
E
I
E
D
---------------------
G
V
E
--------
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
--------
V
N
Y
E
PL
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-
L
G
D
T
K
Q
E
T
L
A
N
I
T
A
V
S
Y
----
D
----
F
D
----
E
E
FF
S
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
T
P
V
D
T
Q
Q
A
M
V
R
R
E
S
V
V
N
L
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
78.55
30%
-36
- C1 -
-
2A2A
3
DAPK2_HUMAN
A:
[10-295]
----------------
V
E
D
F
Y
D
I
G
E
E
--
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
--------
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
Q
S
R
A
S
R
R
G
---
V
S
R
E
E
I
E
R
E
V
S
I
L
R
Q
V
L
H
H
-
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
-
D
F
L
A
Q
K
E
S
--
L
-
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
K
---
N
IP
I
P
H
---
I
K
L
I
D
F
G
L
A
H
E
I
E
D
---------------------
G
V
E
--------
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
--------
V
N
Y
E
PL
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-
L
G
D
T
K
Q
E
T
L
A
N
I
T
S
V
S
Y
----
D
----
F
D
----
E
E
FF
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
T
P
V
D
N
Q
Q
A
M
V
R
R
E
S
V
V
N
L
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
78.39
30%
-106
- C- -
-
3FE3
-
MARK3_HUMAN
B:
[50-312]
--------------
Q
P
H
I
G
N
Y
R
L
L
--
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
--------
L
T
G
R
E
V
A
I
K
I
I
D
K
T
Q
L
N
-------
P
T
S
L
Q
K
L
F
R
E
V
R
I
M
K
I
L
-
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
I
M
E
Y
A
S
G
G
E
V
F
-
D
Y
L
V
A
H
--
G
R
M
-
K
E
K
E
A
R
S
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
R
I
V
H
R
D
L
K
A
E
N
L
L
L
--
D
A
D
---
M
----
N
---
I
K
I
A
D
F
G
F
S
N
E
F
T
V
G
-----------------------------
G
K
L
D
A
F
C
G
A
P
P
Y
A
A
P
E
L
F
Q
G
K
-----
K
Y
D
--
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
Q
N
L
---
K
E
L
R
E
R
V
L
R
G
----
K
----
Y
R
----
I
P
--
F
Y
M
S
T
D
C
E
N
L
L
K
R
F
L
V
L
N
P
I
K
R
G
T
L
E
Q
I
M
K
D
R
W
I
N
A
G
-----
H
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
78.21
30%
-40
- C1 -
-
2A27
2
DAPK2_HUMAN
A:
[10-292]
----------------
V
E
D
F
Y
D
I
G
E
E
--
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
--------
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
Q
S
R
A
S
R
R
G
---
V
S
R
E
E
I
E
R
E
V
S
I
L
R
Q
V
L
H
H
-
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
-
D
F
L
A
Q
K
E
S
--
L
-
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
K
---
N
IP
I
P
H
---
I
K
L
I
D
F
G
L
A
H
E
I
E
D
---------------------
G
V
E
--------
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
--------
V
N
Y
E
PL
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-
L
G
D
T
K
Q
E
T
L
A
N
I
T
A
V
S
Y
----
D
----
F
D
----
E
E
FF
S
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
T
P
V
D
N
Q
Q
A
M
V
R
R
E
S
V
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
78.16
30%
-41
- C1 -
-
1Z9X
-
DAPK2_HUMAN
A:
[9-294]
----------------
V
E
D
F
Y
D
I
G
E
E
--
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
--------
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
Q
S
R
A
S
R
R
G
---
V
S
R
E
E
I
E
R
E
V
S
I
L
R
Q
V
L
H
H
-
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
-
D
F
L
A
Q
K
E
S
--
L
-
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
K
---
N
IP
I
P
H
---
I
K
L
I
D
F
G
L
A
H
E
I
E
D
---------------------
G
V
E
--------
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
--------
V
N
Y
E
PL
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-
L
G
D
T
K
Q
E
T
L
A
N
I
T
S
V
S
Y
----
D
----
F
D
----
E
E
FF
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
T
P
V
D
N
Q
Q
A
M
V
R
R
E
S
V
V
N
L
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
76.32
31%
-129
- C1 -
-
5K00
1
MELK_HUMAN
A:
[4-268]
--------------
D
E
L
L
K
Y
Y
E
L
H
--
E
T
I
G
T
G
--
A
K
V
K
L
A
C
H
I
L
--------
T
G
E
M
V
A
I
K
I
M
D
K
N
T
L
G
--------
S
D
L
P
R
I
K
T
E
I
E
A
L
K
N
L
-
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
-
D
Y
I
I
S
Q
--
D
R
L
-
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
--
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
L
C
A
K
P
----------------------------------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
-----
S
Y
L
--
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
---
V
M
A
L
Y
K
K
I
M
R
G
----
K
----
Y
D
----
V
P
--
K
W
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
L
L
N
H
P
W
I
M
Q
D
-----
Y
N
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
75.12
34%
-85
- C1 -
-
2X4F
4
MYLK4_HUMAN
A:
[89-350]
--------------------
Y
T
V
S
K
T
E
I
L
G
-----
Q
V
H
K
C
E
E
T
A
--------
T
G
L
K
L
A
A
K
I
I
K
T
R
G
M
K
---------
D
K
E
E
V
K
N
E
I
S
V
M
N
Q
L
-
D
H
A
N
L
I
Q
L
Y
D
A
F
E
S
K
N
D
I
V
L
V
M
E
Y
V
D
G
G
E
L
F
-
D
R
I
I
D
E
-
S
Y
N
L
-
T
E
L
D
T
I
L
F
M
K
Q
I
C
E
G
I
R
H
M
H
Q
M
Y
I
L
H
L
D
L
K
P
E
N
I
L
C
VN
R
D
A
---
K
----
Q
---
I
K
I
I
D
F
G
L
A
R
R
Y
K
P
R
-----------------------------
E
K
L
K
V
N
F
G
T
P
E
F
L
A
P
E
V
V
N
Y
D
------
F
V
--
S
F
P
T
D
M
W
S
V
G
V
I
A
Y
M
L
L
S
G
L
S
P
F
L
G
D
N
D
A
---
E
T
L
N
N
I
L
A
C
RWDL
E
----
D
E
----
E
F
--
Q
D
I
S
E
E
A
K
E
F
I
S
K
L
L
I
K
E
K
S
W
R
I
S
A
S
E
A
L
K
H
P
W
L
S
D
H
-----
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
74.77
27%
-109
- C1 -
-
4CZU
3
CIPKN_ARATH
A:
[11-273]
------------------
G
K
Y
E
L
--
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
--------
G
D
N
V
A
I
K
V
I
D
K
E
K
V
L
K
------
N
K
M
I
A
Q
I
K
R
E
I
S
T
M
K
L
I
-
K
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
-
D
K
I
--
S
S
N
G
R
L
-
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
--
D
A
N
---
G
----
A
---
L
K
V
S
D
F
G
L
S
-----------------------
A
L
P
Q
Q
V
R
E
D
G
---
L
L
H
D
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
-----
G
Y
D
--
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
N
L
T
S
---
L
Y
K
K
I
F
K
A
----
E
----
F
T
----
C
P
--
P
W
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
E
V
I
E
N
E
W
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
74.27
27%
-88
- C1 -
-
2Y7J
1
PHKG2_HUMAN
C:
[92-364]
----------------
F
Y
Q
K
Y
D
P
K
--
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
--------
A
T
G
H
E
F
A
V
K
I
M
E
V
T
A
E
R
L
-
S
P
E
Q
L
E
E
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
-
D
Y
L
T
E
K
--
V
A
L
-
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
--
D
D
N
---
M
----
Q
---
I
R
L
S
D
F
G
F
S
C
H
L
E
P
G
-----------------------------
E
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
C
S
M
D
E
T
H
P
G
Y
--
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
R
R
Q
I
---
L
M
L
R
M
I
M
E
G
----
Q
YQFS
S
P
----
E
W
--
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
A
E
Q
A
L
Q
H
P
F
F
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
73.96
29%
-59
- C1 -
-
4TL0
2
DAPK1_HUMAN
A:
[21-277]
----------------------------
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
--------
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
R
R
G
---
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
-
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
-
D
F
L
A
E
K
E
S
--
L
-
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
R
---
N
VP
K
P
R
---
I
K
I
I
D
F
G
L
A
H
K
---
I
D
F
G
N
E
F
K
--------------------------
N
I
F
G
T
P
E
F
V
A
P
E
I
--------
V
N
Y
E
PL
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-
L
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
----
E
----
F
E
----
D
E
YF
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
73.65
29%
-57
- C1 -
-
2X0G
-
DAPK1_HUMAN
A:
[19-275]
----------------------------
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
--------
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
R
R
G
---
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
-
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
-
D
F
L
A
E
K
E
S
--
L
-
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
R
---
N
VP
K
P
R
---
I
K
I
I
D
F
G
L
A
H
K
---
I
D
F
G
N
E
F
K
--------------------------
N
I
F
G
T
P
E
F
V
A
P
E
I
--------
V
N
Y
E
PL
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-
L
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
----
E
----
F
E
----
D
E
YF
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
73.45
29%
-56
- C1 -
-
2Y0A
1
DAPK1_HUMAN
A:
[19-275]
----------------------------
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
--------
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
R
R
G
---
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
-
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
-
D
F
L
A
E
K
E
S
--
L
-
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
R
---
N
VP
K
P
R
---
I
K
I
I
D
F
G
L
A
H
K
---
I
D
F
G
N
E
F
K
--------------------------
N
I
F
G
T
P
E
F
V
A
P
E
I
--------
V
N
Y
E
PL
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-
L
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
----
E
----
F
E
----
D
E
YF
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
73.39
27%
-86
- C1 -
-
2Y7J
1
PHKG2_HUMAN
D:
[91-364]
---------------
E
F
Y
Q
K
Y
D
P
K
--
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
--------
A
T
G
H
E
F
A
V
K
I
M
E
V
---
R
L
-
S
P
E
Q
L
E
E
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
-
D
Y
L
T
E
K
--
V
A
L
-
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
--
D
D
N
---
M
----
Q
---
I
R
L
S
D
F
G
F
S
C
H
L
E
P
G
-----------------------------
E
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
C
S
M
D
E
T
H
P
G
Y
--
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
R
R
Q
I
---
L
M
L
R
M
I
M
E
G
----
Q
YQFS
S
P
----
E
W
--
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
A
E
Q
A
L
Q
H
P
F
F
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
73.19
27%
-107
- C1 -
-
4CZT
3
CIPKN_ARATH
A:
[11-270]
------------------
G
K
Y
E
L
--
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
--------
G
D
N
V
A
I
K
V
I
D
K
E
K
V
L
K
------
N
K
M
I
A
Q
I
K
R
E
I
S
T
M
K
L
I
-
K
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
-
D
K
I
--
S
S
N
G
R
L
-
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
--
D
A
N
---
G
----
A
---
L
K
V
S
D
F
G
L
S
A
L
------------
P
Q
Q
V
R
E
D
G
L
L
H
T
T
C
--------------
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
-----
G
Y
D
--
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
N
L
T
S
---
L
Y
K
K
I
F
K
A
----
E
----
F
T
----
C
P
--
P
W
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
E
V
I
E
N
E
W
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
72.97
28%
-52
- C1 -
-
3MFU
1
CSKP_HUMAN
A:
[19-292]
-------------
D
V
L
F
E
D
V
Y
E
L
--
C
E
V
I
G
K
G
A
F
S
V
V
R
R
C
I
--------
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
----
V
A
K
F
T
S
S
P
G
L
S
T
E
D
L
K
R
E
A
S
I
C
-
H
M
L
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
E
N
V
L
L
--
A
S
K
---
E
----
N
S
A
P
V
K
L
G
D
F
G
V
A
-----
I
Q
L
G
E
S
G
-----------------------
L
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
-----
V
-
K
R
E
P
Y
--
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
----
G
T
K
E
R
L
F
E
G
I
I
K
G
----
K
----
Y
K
MNPR
Q
W
--
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------