@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_19_0140: (2018-03-09 )
MAAISTKELMEVTLGKKLGAGSFGSVFVGVLPSGNFVAVKILELSDDAPSNTEVEIHRKMVHPNIIRYLYSRIDLESTPKKLYVYLEFVTGGSVTSLMKSLPNGCLPYAVVRVYARHMFQGLEYLHSNQVAHRDIKGDNVLISMDTGTAKLADFDQAKIMNTHGTLRKAATATLAGTPYWMAPEVITDEDGYDPFKADIWSAGCTVAEMITGRAPWTPMPNVMHIMNKLALSTGWPDAVPKDAKELGSQDAYDFLDLCFQRDVSKRPPAATLLKHVFLRV
Atome Classification :
(20 SA)
----------------------------------------------.........10-----------........20........30.........40........50---........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
----------------------------------------------MAAI
S
T
K
E
L
M
E
-----------
V
T
LGKKLGAGSF
G
S
V
F
V
G
V
-LPSG
N
F
V
A
V
K
I
L
E
LSDDAPSN---T
E
V
E
I
H
R
K
MV
H
P
N
I
I
R
Y
L
Y
S
RIDLESTP
K
K
L
Y
V
Y
L
E
F
VTGG
S
V
T
S
L
M
K
SLPNG
C
L
P
Y
A
V
V
R
V
Y
A
R
H
M
F
Q
G
L
E
Y
L
H
SNQVAHRDIKGD
N
V
L
I
S
MDTGTAKLADFDQ
A
K
I
MNTHG
T
L
R
K
A
A
T
ATLAGTPYWMAPEVITDEDGYD
P
F
K
A
D
IWSAG
C
T
V
A
E
M
ITGRAPWTPM
P
N
V
M
H
I
M
N
K
L
ALSTGWPDAV
P
K
D
A
K
E
LGS
Q
D
A
Y
D
F
L
D
L
C
F
QRDVSKRP
P
A
A
T
L
L
K
H
V
F
LRV--------------------
12
PsiBlast_PDB
83.30
35%
-31
- C1 -
-
4EQC
1
PAK1_HUMAN
A:
[30-279]
------------------------------------------------------------------------
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
R
Q
M
N
L
Q
Q
Q
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
----
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
---
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
-
G
S
V
K
L
T
D
F
G
----
F
C
A
Q
I
T
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-
R
K
A
Y
G
P
-
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
-
E
N
P
L
R
A
L
Y
L
I
A
-
T
N
G
T
P
E
L
--
Q
N
P
E
K
L
-
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
--------------------
2
PsiBlast_PDB
82.28
36%
-39
- C1 -
-
4ZJJ
1
PAK1_HUMAN
A:
[28-277]
------------------------------------------------------------------------
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
----
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
----
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
---
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
-
G
S
V
K
L
T
D
F
G
----
F
C
A
Q
I
T
-------
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-
R
K
A
Y
G
P
-
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
-
E
N
P
L
R
A
L
Y
L
I
A
-
T
N
G
T
P
E
L
--
Q
N
P
E
K
L
-
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
--------------------
7
PsiBlast_PDB
81.69
35%
-28
- C1 -
-
1YHW
-
PAK1_HUMAN
A:
[274-523]
------------------------------------------------------------------------
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
R
Q
M
N
L
Q
Q
Q
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
----
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
---
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
-
G
S
V
K
L
T
D
F
G
----
F
C
A
Q
I
T
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-
R
K
A
Y
G
P
-
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
-
E
N
P
L
R
A
L
Y
L
I
A
-
T
N
G
T
P
E
L
--
Q
N
P
E
K
L
-
S
A
I
F
R
D
F
L
N
R
C
L
D
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
--------------------
15
PsiBlast_PDB
81.08
35%
-27
- C1 -
-
5DEW
1
PAK1_HUMAN
A:
[26-275]
------------------------------------------------------------------------
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
Q
Q
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
----
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
---
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
-
G
S
V
K
L
T
D
F
G
----
F
C
A
Q
I
T
P
E
Q
S
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-
R
K
A
Y
G
P
-
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
-
E
N
P
L
R
A
L
Y
L
I
A
-
T
N
G
T
P
E
L
--
Q
N
P
E
K
L
-
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
--------------------
10
PsiBlast_PDB
81.05
35%
-29
- C1 -
-
4DAW
-
PAK1_HUMAN
A:
[26-275]
------------------------------------------------------------------------
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
R
Q
M
N
L
Q
Q
Q
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
----
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
---
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
-
G
S
V
K
L
T
D
F
G
----
F
C
A
Q
I
T
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-
R
K
A
Y
G
P
-
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
-
E
N
P
L
R
A
L
Y
L
I
A
-
T
N
G
T
P
E
L
--
Q
N
P
E
K
L
-
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
--------------------
16
PsiBlast_PDB
80.80
35%
-29
- C1 -
-
4O0R
1
PAK1_HUMAN
A:
[26-275]
------------------------------------------------------------------------
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
Q
Q
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
----
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
---
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
-
G
S
V
K
L
T
D
F
G
----
F
C
A
Q
I
T
P
E
Q
S
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-
R
K
A
Y
G
P
-
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
-
E
N
P
L
R
A
L
Y
L
I
A
-
T
N
G
T
P
E
L
--
Q
N
P
E
K
L
-
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
--------------------
8
PsiBlast_PDB
80.80
35%
-29
- C1 -
-
3FXZ
1
?
A:
[26-275]
------------------------------------------------------------------------
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
R
Q
M
N
L
Q
Q
Q
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
----
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
---
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
-
G
S
V
K
L
T
D
F
G
----
F
C
A
Q
I
T
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-
R
K
A
Y
G
P
-
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
-
E
N
P
L
R
A
L
Y
L
I
A
-
T
N
G
T
P
E
L
--
Q
N
P
E
K
L
-
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
--------------------
19
PsiBlast_PDB
80.70
34%
-26
- C1 -
-
3Q53
1
PAK1_HUMAN
A:
[27-276]
------------------------------------------------------------------------
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
R
Q
M
N
L
Q
Q
Q
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
----
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
---
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
-
G
S
V
K
L
T
D
F
G
----
F
C
A
Q
I
T
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-
R
K
A
Y
G
P
-
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
-
E
N
P
L
R
A
L
Y
L
I
A
-
T
N
G
T
P
E
L
--
Q
N
P
E
K
L
-
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
I
Q
H
Q
F
L
K
I
--------------------
1
PsiBlast_PDB
80.57
36%
-36
- C1 -
-
4ZJI
1
PAK1_HUMAN
A:
[28-277]
------------------------------------------------------------------------
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
-----
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
----
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
---
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
-
G
S
V
K
L
T
D
F
G
----
F
C
A
Q
I
T
P
------
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-
R
K
A
Y
G
P
-
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
-
E
N
P
L
R
A
L
Y
L
I
A
-
T
N
G
T
P
E
L
--
Q
N
P
E
K
L
-
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
--------------------
17
PsiBlast_PDB
80.10
35%
-28
- C1 -
-
4O0T
1
PAK1_HUMAN
A:
[26-275]
------------------------------------------------------------------------
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
Q
Q
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
----
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
---
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
-
G
S
V
K
L
T
D
F
G
----
F
C
A
Q
I
T
P
E
Q
S
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-
R
K
A
Y
G
P
-
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
-
E
N
P
L
R
A
L
Y
L
I
A
-
T
N
G
T
P
E
L
--
Q
N
P
E
K
L
-
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
--------------------
9
PsiBlast_PDB
79.76
35%
-27
- C1 -
-
3FY0
1
PAK1_HUMAN
A:
[26-275]
------------------------------------------------------------------------
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
R
Q
M
N
L
Q
Q
Q
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
----
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
---
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
-
G
S
V
K
L
T
D
F
G
----
F
C
A
Q
I
T
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-
R
K
A
Y
G
P
-
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
-
E
N
P
L
R
A
L
Y
L
I
A
-
T
N
G
T
P
E
L
--
Q
N
P
E
K
L
-
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
--------------------
11
PsiBlast_PDB
79.50
35%
-23
- C1 -
-
5DFP
2
PAK1_HUMAN
A:
[26-275]
------------------------------------------------------------------------
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
R
Q
M
N
L
Q
Q
Q
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
----
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
---
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
-
G
S
V
K
L
T
D
F
G
----
F
C
A
Q
I
T
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-
R
K
A
Y
G
P
-
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
-
E
N
P
L
R
A
L
Y
L
I
A
-
T
N
G
T
P
E
L
--
Q
N
P
E
K
L
-
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
--------------------
20
PsiBlast_PDB
78.48
35%
-27
- C1 -
-
1YHV
-
?
A:
[274-523]
------------------------------------------------------------------------
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
R
Q
M
N
L
Q
Q
Q
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
----
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
---
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
-
G
S
V
K
L
T
D
F
G
----
F
C
A
Q
I
T
P
E
Q
S
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-
R
K
A
Y
G
P
-
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
-
E
N
P
L
R
A
L
Y
L
I
A
-
T
N
G
T
P
E
L
--
Q
N
P
E
K
L
-
S
A
I
F
R
D
F
L
N
R
C
L
D
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
--------------------
6
PsiBlast_PDB
77.72
35%
0
- C- -
-
1F3M
-
?
C:
[26-275]
------------------------------------------------------------------------
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
R
Q
M
N
L
Q
Q
Q
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
----
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
---
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
-
G
S
V
K
L
T
D
F
G
----
F
C
A
Q
I
T
-------
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-
R
K
A
Y
G
P
-
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
-
E
N
P
L
R
A
L
Y
L
I
A
-
T
N
G
T
P
E
L
--
Q
N
P
E
K
L
-
S
A
I
F
R
D
F
L
N
R
C
L
D
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
--------------------
14
PsiBlast_PDB
77.42
35%
-30
- C1 -
-
5DEY
1
PAK1_HUMAN
A:
[26-275]
------------------------------------------------------------------------
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
Q
Q
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
----
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
---
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
-
G
S
V
K
L
T
D
F
G
----
F
C
A
Q
I
T
P
E
Q
S
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-
R
K
A
Y
G
P
-
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
-
E
N
P
L
R
A
L
Y
L
I
A
-
T
N
G
T
P
E
L
--
Q
N
P
E
K
L
-
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
--------------------
13
PsiBlast_PDB
77.30
34%
-32
- C1 -
-
3Q4Z
1
PAK1_HUMAN
A:
[27-276]
------------------------------------------------------------------------
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D----
Q
E
V
A
I
R
Q
M
N
L
-----
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
----
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
---
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
-
G
S
V
K
L
T
D
F
G
----
F
C
A
Q
I
T
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-
R
K
A
Y
G
P
-
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
-
E
N
P
L
R
A
L
Y
L
I
A
-
T
N
G
T
P
E
L
--
Q
N
P
E
K
L
-
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
I
Q
H
Q
F
L
K
I
--------------------
4
PsiBlast_PDB
74.68
35%
-28
- C1 -
-
4ZY6
1
PAK1_HUMAN
A:
[27-276]
------------------------------------------------------------------------
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
------
Q
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
----
V
--
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
---
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
-
G
S
V
K
L
T
D
F
G
----
F
C
A
Q
I
T
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-
R
K
A
Y
G
P
-
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
-
E
N
P
L
R
A
L
Y
L
I
A
-
T
N
G
T
P
E
L
--
Q
N
P
E
K
L
-
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
--------------------
45
Fugue
73.47
30%
-5
- C1 -
-
4DN5
7
M3K14_HUMAN
A:
[8-351]
S
V
E
E
Y
L
V
H
A
L
QG
S
V
S
S
G
Q
A
H
S
L
T
S
L
A
K
T
W
A
A
R
G
S
RSREPSPKTE
D
N
E
G
V
L
L
T
E
K
L
K
P
V
DY
E
Y
R
E
EVH
W
A
T
H
Q
L
R
L
G
R
G
S
F
G
E
V
H
R
M
E
D
K
Q
T
G
F
Q
C
A
V
K
K
V
R
L
E
V
F
R
A
-----
E
E
L
M
A
C
A
G
L
T
S
P
R
I
V
P
L
Y
----
G
A
V
R
E
G
P
W
V
N
I
F
M
E
L
L
E
G
G
S
L
G
Q
L
V
K
E
Q
--
G
C
L
P
E
D
R
A
L
Y
Y
L
G
Q
A
L
E
G
L
E
Y
L
H
S
R
R
I
L
H
G
D
V
K
A
D
N
V
L
L
S
S
D
G
S
H
A
A
L
C
D
F
G
H
A
V
C
L
Q
------------
I
P
G
T
E
T
H
M
A
P
E
V
V
L
-
G
R
S
C
D
A
-
K
V
D
V
W
S
S
C
C
M
M
L
H
M
L
N
G
C
H
P
W
T
Q
F
F
R
-
G
P
L
C
L
K
I
A
S
E
P
P
P
V
R
E
I
P
P
S
C
----
A
P
L
T
A
Q
A
I
Q
E
G
L
R
K
E
P
I
H
R
V
S
A
A
E
L
G
G
K
V
N
R
A
L
Q
Q
V
GGLKSPWR
G
E
Y
K
E
P
RHP
5
PsiBlast_PDB
73.36
35%
-30
- C1 -
-
4ZLO
2
PAK1_HUMAN
A:
[26-275]
------------------------------------------------------------------------
E
K
I
G
Q
--
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
-----
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
----
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
---
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
-
G
S
V
K
L
T
D
F
G
-------------
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-
R
K
A
Y
G
P
-
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
-
E
N
P
L
R
A
L
Y
L
I
A
-
T
N
G
T
P
E
L
--
Q
N
P
E
K
L
-
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
--------------------
18
PsiBlast_PDB
69.78
34%
-
- C1 -
-
3Q52
-
PAK1_HUMAN
A:
[274-523]
------------------------------------------------------------------------
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
R
Q
M
N
L
Q
Q
Q
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
----
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
---
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
-
G
S
V
K
L
T
D
F
G
----
F
C
A
Q
I
T
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-
R
K
A
Y
G
P
-
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
-
E
N
P
L
R
A
L
Y
L
I
A
-
T
N
G
T
P
E
L
--
Q
N
P
E
K
L
-
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
I
Q
H
Q
F
L
K
I
--------------------