@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_19_0170: (2018-03-09 )
MERYTVMGQLGDGSFGTVSKAQNTSTGEIVAVKKMKQRFHSWEECLQLREIQSLRKVQHPNLVKLKEVVREKTELFMIFEYCEKNIFQIQRQRANEMSGTMAFSDKEIRSIMCQTLLGVQAIHKAGFMHRDLKPENLLISGDLVKVADFGLAKEIRSRPPFTEYVSTRWYRAPELVLHSTHYNSPVDIWACAVIFAELYLCRPLFPGTSESDQLFKICSVLGSPAPNEWDEGYQLARRMNMRFPTVAPTPLRHILTTAPPAAVDLMAQMLRFNPAERPTATQCLQHPYFTGSGGSSALYAGIATGQPHNPFQLAASSAVAAQSMSNVGLTSNSSPPPTTSNASLFKYANLFNQGNRSPLSVSSTSAPFSGSSALQGSVTSSNMVRSVPTQRKTSVPNAVDSDDEFNF
Atome Classification :
(20 SA)
.........10........20........30........40-..-...---...50........60........70-----.------.-----.......80........90........100.......110.......120.......130.......140..---.......150..----..-...-----160.......170.......180.......190.......200.......210.......220.......230...-..-...240....-...-250....-....260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
ME
R
Y
T
V
M
G
QLGDGSFG
T
V
SKAQNTSTGE
I
V
A
V
K
K
M
K
Q
R
F
H
S
-
W
E
-
E
C
L
---
Q
L
R
E
I
Q
S
L
R
KVQHP
N
L
V
K
L
K
E
V
V
R
------
E
------K-----T
E
L
F
M
I
F
E
Y
C
E
K
N
I
F
Q
I
Q
R
Q
R
A
N
EMSG
T
M
AF
S
D
K
E
I
R
S
I
M
C
Q
T
L
L
G
V
Q
A
I
H
K
AGFMHRDLKPE
N
L
L
IS--G
D
---
L
V
K
V
A
D
F
G
L
A
K
E
----
I
R-SRP-----P
F
T
E
Y
V
S
T
RWYRAP
E
L
V
L
H
STHYNS
P
V
D
I
W
A
C
A
V
I
F
A
E
L
Y
L
CRPLFPGTSE
S
D
Q
L
F
K
I
C
S
V
LGSPAPN
E
W
D
E
-
G
Y
Q
-
L
A
-
R
R
MNMRFPTV-A
P
T
-
P
L
-
R
H
I
L-TTA
P
P
A
A
V
D
L
M
A
Q
M
L
RFNPAER
P
T
A
T
Q
C
L
QHPYFTGSGGSS
A
L
Y
A
GIATGQPHN
P
F
Q
L
AA
S
S
A
V
A
A
Q
S
M
SNVGLTSNSSPPPTTSN
A
S
L
F
K
Y
A
N
L
F
NQGNRS
P
L
SVSSTSAPFSGSSALQGSVTSS
N
M
V
R
SVPTQRKTSVPNAVDSDDEFNF
15
PsiBlast_PDB
84.98
37%
-66
- C- -
-
3GBZ
-
?
A:
[12-302]
I
D
R
Y
R
R
I
T
K
L
G
E
G
T
Y
G
E
V
Y
K
A
I
D
T
V
T
N
E
T
V
A
I
K
R
I
--
R
L
E
H
----------
A
I
R
E
V
S
L
L
K
E
L
Q
H
R
N
I
I
E
L
K
S
V
I
H
------
H
------
N
-----
H
R
L
H
L
I
F
E
Y
A
E
N
D
L
-------
K
K
Y
M
D
K
N
P
D
V
S
M
R
V
I
K
S
F
L
Y
Q
L
I
N
G
V
N
F
C
H
S
R
R
C
L
H
R
D
L
K
P
Q
N
L
L
L
S
--
V
-T
P
-
V
L
K
I
G
D
F
G
L
A
R
A
FG--------------------
T
L
W
Y
R
P
P
E
I
L
L
G
S
R
H
Y
S
T
S
V
D
I
W
S
I
A
C
I
W
A
E
M
L
M
K
T
P
L
F
P
G
D
S
E
I
D
Q
L
F
K
I
F
E
V
L
G
L
P
D
D
T
T
W
-
P
-
G
V
T
-
A
L
-
P
D
W
K
Q
S
F
P
K
F
-
R
G
K
-
T
L
-
K
R
V
L
G
A
L
L
D
D
E
G
L
D
L
L
T
A
M
L
E
M
D
P
V
K
R
I
S
A
K
N
A
L
E
H
P
Y
F
S
---------------------------------------------------------------------------------------------------------------------
25
HHSearch
83.82
34%
-20
- C1 -
-
5BYZ
7
MK07_HUMAN
A:
[6-304]
-
D
E
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
R
L
T
G
Q
Q
V
A
I
K
K
I
P
N
A
F
D
V
V
T
N
-
A
K
R
---
T
L
R
E
L
K
I
L
K
H
F
K
H
D
N
I
I
A
I
K
D
I
L
R
P
TVPYG
E
------
F
-----
K
S
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
H
S
S
-------
Q
P
L
T
L
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
--
E
N
C--
E
L
K
I
G
D
F
G
M
A
R
G
----
L
C
-
T
S
P
AEHQY
F
M
T
E
Y
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
R
R
Q
L
F
P
G
K
N
Y
V
H
Q
L
Q
L
I
M
M
V
L
G
T
P
S
P
A
V
I
Q
A
-
V
G
A
E
R
V
-
R
A
Y
I
Q
S
L
P
P
R
-
Q
P
V
-
P
W
-
E
T
V
Y
-
P
G
A
D
R
Q
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
Y
H
------------------------------------------------------------------------------------------------------------------
26
HHSearch
81.58
38%
-49
- C1 -
-
1UA2
1
CDK7_HUMAN
D:
[13-299]
----
E
K
L
D
F
L
G
E
G
Q
F
A
T
V
Y
K
A
R
D
K
N
T
N
Q
I
V
A
I
K
K
I
----------
N
R
T
---
A
L
R
E
I
K
L
L
Q
E
L
S
H
P
N
I
I
G
L
L
D
A
F
G
------
H
------
K
-----
S
N
I
S
L
V
F
D
F
M
E
T
D
L
E
V
I
I
K
D
N
------
S
L
V
L
T
P
S
H
I
K
A
Y
M
L
M
T
L
Q
G
L
E
Y
L
H
Q
H
W
I
L
H
R
D
L
K
P
N
N
L
L
L
D
--
E
N
G--
V
L
K
L
A
D
F
G
L
A
K
S
----
F
G
-
S
P
N
R----
A
Y
T
H
Q
V
V
T
R
W
Y
R
A
P
E
L
L
F
G
A
R
M
Y
G
V
G
V
D
M
W
A
V
G
C
I
L
A
E
L
L
L
R
V
P
F
L
P
G
D
S
D
L
D
Q
L
T
R
I
F
E
T
L
G
T
P
T
E
E
Q
W
P
D
-
M
C
S
-
L
P
-
D
Y
V
T
--
F
K
S
F
-
P
G
I
-
P
L
-
H
H
I
F
-
S
A
A
G
D
D
L
L
D
L
I
Q
G
L
F
L
F
N
P
C
A
R
I
T
A
T
Q
A
L
K
M
K
Y
F
S
N
R
P
------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
81.58
36%
-9
- C1 -
-
3PXF
7
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--
R
L
D
T
-
E
T
-
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
-----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
-----
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
--
T
E
G--
A
I
K
L
A
D
F
G
L
A
R
A
F
GVP
V
R
-
T
--------
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
-
G
V
T
-
S
M
-
P
D
Y
K
P
S
F
P
K
W
-
A
R
Q
-
D
F
-
S
K
V
V
-
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
----------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
80.67
37%
4
- C1 -
-
5HQ0
1
CDK1_HUMAN
A:
[6-292]
M
E
D
Y
T
K
I
E
K
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
K
T
T
G
Q
V
V
A
M
K
K
I
--
R
L
E
S
-
E
E
-
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
R
H
P
N
I
V
S
L
Q
D
V
L
M
------
Q
------
D
-----
S
R
L
Y
L
I
F
E
F
L
S
M
D
L
----
K
K
Y
L
D
S
I
P
P
G
Q
Y
M
D
S
S
L
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
D
--
D
K
G--
T
I
K
L
A
D
F
G
L
A
R
A
FGIP
I
R
-
V
--------
Y
T
H
E
V
V
T
L
W
Y
R
S
P
E
V
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
T
K
K
P
L
F
H
G
D
S
E
I
D
Q
L
F
R
I
F
R
A
L
G
T
P
N
N
E
V
W
P
E
-
V
E
S
-
L
Q
-
D
Y
K
N
T
-
F
P
K
W
-
K
P
G
-
S
L
-
A
S
H
V
-
K
N
L
D
E
N
G
L
D
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
----------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
80.67
37%
4
- C1 -
-
4Y72
1
CDK1_HUMAN
A:
[6-292]
M
E
D
Y
T
K
I
E
K
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
K
T
T
G
Q
V
V
A
M
K
K
I
--
R
L
E
S
-
E
E
-
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
R
H
P
N
I
V
S
L
Q
D
V
L
M
------
Q
------
D
-----
S
R
L
Y
L
I
F
E
F
L
S
M
D
L
----
K
K
Y
L
D
S
I
P
P
G
Q
Y
M
D
S
S
L
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
D
--
D
K
G--
T
I
K
L
A
D
F
G
L
A
R
A
FGIP
I
R
-
V
--------
Y
T
H
E
V
V
T
L
W
Y
R
S
P
E
V
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
T
K
K
P
L
F
H
G
D
S
E
I
D
Q
L
F
R
I
F
R
A
L
G
T
P
N
N
E
V
W
P
E
-
V
E
S
-
L
Q
-
D
Y
K
N
T
-
F
P
K
W
-
K
P
G
-
S
L
-
A
S
H
V
-
K
N
L
D
E
N
G
L
D
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
----------------------------------------------------------------------------------------------------------------------
28
HHSearch
79.57
31%
-72
- C1 -
-
5G6V
3
CDK16_HUMAN
B:
[1-289]
M
E
T
Y
I
K
L
D
K
L
G
E
G
T
Y
A
T
V
Y
K
G
K
S
K
L
T
D
N
L
V
A
L
K
E
I
R
L
E
H
E
E
-
G
A
-
P
C
T
---
A
I
R
E
V
S
L
L
K
D
L
K
H
A
N
I
V
T
L
H
D
I
I
H
------
T
------
E
-----
K
S
L
T
L
V
F
E
Y
L
D
K
D
L
K
Q
Y
L
D
D
C
G
------
N
I
I
N
M
H
N
V
K
L
F
L
F
Q
L
L
R
G
L
A
Y
C
H
R
Q
K
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
--
E
R
G--
E
L
K
L
A
D
F
G
L
A
R
A
---------------------
V
T
L
W
Y
R
P
P
D
I
L
L
G
S
T
D
Y
S
T
Q
I
D
M
W
G
V
G
C
I
F
Y
E
M
A
T
G
R
P
L
F
P
G
S
T
V
E
E
Q
L
H
F
I
F
R
I
L
G
T
P
T
E
E
T
W
P
G
-
I
L
S
-
N
E
-
E
F
K
T
Y
N
Y
P
K
Y
-
R
A
E
-
A
L
-
L
S
H
A
-
P
R
L
D
S
D
G
A
D
L
L
T
K
L
L
Q
F
E
G
R
N
R
I
S
A
E
D
A
M
K
H
P
F
F
L
S
L
G
------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
79.38
37%
-1
- C1 -
-
4YC3
1
CDK1_HUMAN
A:
[6-292]
M
E
D
Y
T
K
I
E
K
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
K
T
T
G
Q
V
V
A
M
K
K
I
--
R
L
E
S
-
E
E
-
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
R
H
P
N
I
V
S
L
Q
D
V
L
M
------
Q
------
D
-----
S
R
L
Y
L
I
F
E
F
L
S
M
D
L
----
K
K
Y
L
D
S
I
P
P
G
Q
Y
M
D
S
S
L
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
D
--
D
K
G--
T
I
K
L
A
D
F
G
L
A
R
A
FGIP
I
R
-
V
--------
Y
T
---
V
T
L
W
Y
R
S
P
E
V
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
T
K
K
P
L
F
H
G
D
S
E
I
D
Q
L
F
R
I
F
R
A
L
G
T
P
N
N
E
V
W
P
E
-
V
E
S
-
L
Q
-
D
Y
K
N
T
-
F
P
K
W
-
K
P
G
-
S
L
-
A
S
H
V
-
K
N
L
D
E
N
G
L
D
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
----------------------------------------------------------------------------------------------------------------------
27
HHSearch
78.78
31%
-58
- C1 -
-
5G6V
4
CDK16_HUMAN
A:
[1-289]
M
E
T
Y
I
K
L
D
K
L
G
E
G
T
Y
A
T
V
Y
K
G
K
S
K
L
T
D
N
L
V
A
L
K
E
I
R
L
E
H
E
E
-
G
A
-
P
C
T
---
A
I
R
E
V
S
L
L
K
D
L
K
H
A
N
I
V
T
L
H
D
I
I
H
------
T
------
E
-----
K
S
L
T
L
V
F
E
Y
L
D
K
D
L
K
Q
Y
L
D
D
C
G
------
N
I
I
N
M
H
N
V
K
L
F
L
F
Q
L
L
R
G
L
A
Y
C
H
R
Q
K
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
--
E
R
G--
E
L
K
L
A
D
F
G
L
A
R
A
----
K
----------
T
Y
D
N
E
V
V
T
L
W
Y
R
P
P
D
I
L
L
G
S
T
D
Y
S
T
Q
I
D
M
W
G
V
G
C
I
F
Y
E
M
A
T
G
R
P
L
F
P
G
S
T
V
E
E
Q
L
H
F
I
F
R
I
L
G
T
P
T
E
E
T
W
P
G
-
I
L
S
-
N
E
-
E
F
K
T
Y
N
Y
P
K
Y
-
R
A
E
-
A
L
-
L
S
H
A
-
P
R
L
D
S
D
G
A
D
L
L
T
K
L
L
Q
F
E
G
R
N
R
I
S
A
E
D
A
M
K
H
P
F
F
L
S
L
G
------------------------------------------------------------------------------------------------------------------
40
HHSearch
78.32
35%
-11
- C1 -
-
4ZZN
1
MK01_HUMAN
A:
[13-312]
-
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
N
L
N
K
V
R
V
A
I
K
K
I
S
P
F
E
H
Q
-
T
Y
-
C
Q
R
---
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
------
A
------
P
TIEQM
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
K
T
--------
Q
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
--
T
T
C--
D
L
K
I
C
D
F
G
L
A
R
V
----
A
D
-
P
D
H
D
H
T
G
-
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
Q
L
N
H
I
L
G
I
L
G
S
P
S
Q
E
D
L
N
C
-
I
I
N
-
L
K
A
R
N
Y
L
L
S
L
P
H
K
-
N
K
V
-
P
W
-
N
R
L
F
-
P
N
A
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
-------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
78.30
37%
-25
- C1 -
-
3GC0
1
?
A:
[33-323]
I
D
R
Y
R
R
I
T
K
L
G
E
G
T
Y
G
E
V
Y
K
A
I
D
T
V
T
N
E
T
V
A
I
K
R
I
--
R
L
E
H
-------T--
A
I
R
E
V
S
L
L
K
E
L
Q
H
R
N
I
I
E
L
K
S
V
I
H
------
H
------
N
-----
H
R
L
H
L
I
F
E
Y
A
E
N
D
L
-------
K
K
Y
M
D
K
N
P
D
V
S
M
R
V
I
K
S
F
L
Y
Q
L
I
N
G
V
N
F
C
H
S
R
R
C
L
H
R
D
L
K
P
Q
N
L
L
L
S
--
V
-E
T
P
V
L
K
I
G
D
F
G
L
A
R
A
F------------------
E
I
I
T
L
W
Y
R
P
P
E
I
L
L
G
S
R
H
Y
S
T
S
V
D
I
W
S
I
A
C
I
W
A
E
M
L
M
K
T
P
L
F
P
G
D
S
E
I
D
Q
L
F
K
I
F
E
V
L
G
L
P
D
D
T
T
W
-
P
-
G
V
T
-
A
L
-
P
D
W
K
Q
S
F
P
K
F
-
R
G
K
-
T
L
-
K
R
V
L
G
A
L
L
D
D
E
G
L
D
L
L
T
A
M
L
E
M
D
P
V
K
R
I
S
A
K
N
A
L
E
H
P
Y
F
S
---------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
78.01
36%
-13
- C1 -
-
1V0B
-
CDC2H_PLAFK
A:
[1-284]
M
E
K
Y
H
G
L
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
Q
N
-
N
Y
G
E
T
F
A
L
K
K
I
--
R
L
E
K
-
E
D
-
E
G
I
P
S
T
T
I
R
E
I
S
I
L
K
E
L
K
H
S
N
I
V
K
L
Y
D
V
I
H
------
T
------
K
-----
K
R
L
V
L
V
F
E
H
L
D
Q
D
L
K
K
L
L
D
V
C
E
G
G
L
E
S
V
T
A
------
K
S
F
L
L
Q
L
L
N
G
I
A
Y
C
H
D
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
RE
G
E
---
L
-
K
I
A
D
F
G
L
A
R
A
FG--
I
P
-
V
R
K
------
Y
T
H
E
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
T
I
D
I
W
S
V
G
C
I
F
A
E
M
V
N
G
A
P
L
F
P
G
V
S
E
A
D
Q
L
M
R
I
F
R
I
L
G
T
P
N
S
K
N
W
P
N
-
V
T
E
-
L
P
--
K
Y
D
P
N
F
T
V
Y
-
E
P
L
-
P
W
-
E
S
F
L
-
K
G
L
D
E
S
G
I
D
L
L
S
K
M
L
K
L
D
P
N
Q
R
I
T
A
K
Q
A
L
E
H
A
Y
F
----------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
77.85
36%
-33
- C1 -
-
1OIT
1
CDK2_HUMAN
A:
[3-286]
--
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
-
G
E
V
V
A
L
K
K
I
-------------T--
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
-----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
-----
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
S
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
--
T
E
G--
A
I
K
L
A
D
F
G
L
A
R
A
--------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
-
G
V
T
-
S
M
-
P
D
Y
K
P
S
F
P
K
W
-
A
R
Q
-
D
F
-
S
K
V
V
-
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
----------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
77.42
36%
-7
- C1 -
-
3PXR
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--
R
-----
T
-
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
-----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
-----
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
--
T
E
G--
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-
T
--------
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
-
G
V
T
-
S
M
-
P
D
Y
K
P
S
F
P
K
W
-
A
R
Q
-
D
F
-
S
K
V
V
-
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
----------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
77.24
36%
-19
- C1 -
-
1V0P
1
CDC2H_PLAFK
A:
[1-284]
M
E
K
Y
H
G
L
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
Q
N
-
N
Y
G
E
T
F
A
L
K
K
I
--
R
L
E
K
-
E
D
-
E
G
I
P
S
T
T
I
R
E
I
S
I
L
K
E
L
K
H
S
N
I
V
K
L
Y
D
V
I
H
------
T
------
K
-----
K
R
L
V
L
V
F
E
H
L
D
Q
D
L
K
K
L
L
D
V
C
E
G
G
L
E
S
V
T
A
------
K
S
F
L
L
Q
L
L
N
G
I
A
Y
C
H
D
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
RE
G
E
---
L
-
K
I
A
D
F
G
L
A
R
A
FG------------------
I
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
T
I
D
I
W
S
V
G
C
I
F
A
E
M
V
N
G
T
P
L
F
P
G
V
S
E
A
D
Q
L
M
R
I
F
R
I
L
G
T
P
N
S
K
N
W
P
N
-
V
T
E
-
L
P
--
K
Y
D
P
N
F
T
V
Y
-
E
P
L
-
P
W
-
E
S
F
L
-
K
G
L
D
E
S
G
I
D
L
L
S
K
M
L
K
L
D
P
N
Q
R
I
T
A
K
Q
A
L
E
H
A
Y
F
----------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
76.53
36%
-4
- C1 -
-
3PXQ
4
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--
R
-----
T
-
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
-----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
-----
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
--
T
E
G--
A
I
K
L
A
D
F
G
L
A
R
A
FGVP
V
R
-
T
--------
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
-
G
V
T
-
S
M
-
P
D
Y
K
P
S
F
P
K
W
-
A
R
Q
-
D
F
-
S
K
V
V
-
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
----------------------------------------------------------------------------------------------------------------------
21
HHSearch
76.44
33%
-10
- C1 -
-
1J1B
1
GSK3B_HUMAN
B:
[55-343]
--
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
K
-------
R
F
---
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
------
S
S
GEKKD
E
-----
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
---
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
--
P
D
TA-
V
L
K
L
C
D
F
G
S
A
K
Q
----
L
V
-
R
G
E
-----
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
-
M
N
P
-
N
Y
-
T
--
E
F
K
F
P
Q
I
-
K
A
H
P
W
T
-
K
V
F
R
-
P
R
T
P
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
-------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
75.44
37%
11
- C1 -
-
5LQF
1
CDK1_HUMAN
A:
[6-292]
M
E
D
Y
T
K
I
E
K
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
K
T
T
G
Q
V
V
A
M
K
K
I
--
R
L
E
S
-
E
E
-
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
R
H
P
N
I
V
S
L
Q
D
V
L
M
------
Q
------
D
-----
S
R
L
Y
L
I
F
E
F
L
S
M
D
L
----
K
K
Y
L
D
S
I
P
P
G
Q
Y
M
D
S
S
L
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
D
--
D
K
G--
T
I
K
L
A
D
F
G
L
A
R
A
FGIP
I
R
--------------
V
V
T
L
W
Y
R
S
P
E
V
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
T
K
K
P
L
F
H
G
D
S
E
I
D
Q
L
F
R
I
F
R
A
L
G
T
P
N
N
E
V
W
P
E
-
V
E
S
-
L
Q
-
D
Y
K
N
T
-
F
P
K
W
-
K
P
G
-
S
L
-
A
S
H
V
-
K
N
L
D
E
N
G
L
D
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
----------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
75.09
38%
-29
- C1 -
-
4BGQ
3
CDKL5_HUMAN
A:
[11-298]
M
N
K
F
E
I
L
G
V
V
G
E
G
A
Y
G
V
V
L
K
C
R
H
K
E
T
H
E
I
V
A
I
K
K
F
K
--------V
K
E
T
---
T
L
R
E
L
K
M
L
R
T
L
K
Q
E
N
I
V
E
L
K
E
A
F
R
------
R
------
R
-----
G
K
L
Y
L
V
F
E
Y
V
E
K
N
M
L
E
L
L
E
E
M
P
N
------
G
V
P
P
E
K
V
K
S
Y
I
Y
Q
L
I
K
A
I
H
W
C
H
K
N
D
I
V
H
R
D
I
K
P
E
N
L
L
I
S
H-
N
D
---
V
L
K
L
C
D
F
G
F
A
R
N
----
L
S
E---------------
T
R
W
Y
R
S
P
E
L
L
L
G
A
P
-
Y
G
K
S
V
D
M
W
S
V
G
C
I
L
G
E
L
S
D
G
Q
P
L
F
P
G
E
S
E
I
D
Q
L
F
T
I
Q
K
V
L
G
-
P
L
P
S
E
Q
M
K
L
F
Y
S
-
N
P
-
R
F
H
G
L
R
F
P
A
V
N
H
P
Q
-
S
L
E
R
R
Y
L
-
G
I
L
N
S
V
L
L
D
L
M
K
N
L
L
K
L
D
P
A
D
R
Y
L
T
E
Q
C
L
N
H
P
T
F
----------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
74.06
36%
11
- C1 -
-
1V0O
1
CDC2H_PLAFK
A:
[3-284]
--
K
Y
H
G
L
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
Q
N
-
N
Y
G
E
T
F
A
L
K
K
I
--
R
L
---------S
T
-
T
I
R
E
I
S
I
L
K
E
L
K
H
S
N
I
V
K
L
Y
D
V
I
H
------
T
------
K
-----
K
R
L
V
L
V
F
E
H
L
D
Q
D
L
K
K
L
L
D
V
C
E
G
G
L
E
S
V
T
A
------
K
S
F
L
L
Q
L
L
N
G
I
A
Y
C
H
D
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
RE
G
E
---
L
-
K
I
A
D
F
G
L
A
R
A
FG--
I
P
-
V
R
K
------
Y
T
H
E
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
T
I
D
I
W
S
V
G
C
I
F
A
E
M
V
N
G
T
P
L
F
P
G
V
S
E
A
D
Q
L
M
R
I
F
R
I
L
G
T
P
N
S
K
N
W
P
N
-
V
T
E
-
L
P
--
K
Y
D
P
N
F
T
V
Y
-
E
P
L
-
P
W
-
E
S
F
L
-
K
G
L
D
E
S
G
I
D
L
L
S
K
M
L
K
L
D
P
N
Q
R
I
T
A
K
Q
A
L
E
H
A
Y
F
----------------------------------------------------------------------------------------------------------------------