@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_19_0360: (2018-03-09 )
MPSSNLVTDAYHNTELAINVFFSIHTDANPVMGRKATKASVVPIAASLLPANAAVMIDDDLTPGVADFGATTEPAVRSPSSVEREVFENSIADIGGGGALSQSVVSRRDMSLADISRMRLEGCRARHTLFAATTSLRGSMASSLRSTSGSPMLPLTGRVRDHAGICGETTSAAISAVSQAPAWSSLNGLGRSFNRRSSMLSVRTNALDTSIAILQHMAHDTAARAEAACNAQSLAGTPSTATSACGSVALPSLQPTQPYPEDTHAGARGYKVVGSGNTASVEDSCSGSGQHTPVLHTVHTRQFTSASDSSSPLNSLSESELCSGHLRAGGRSHLSAQASATHLTGSGGVAKAASDLQHSSPRSHPDGSPLAARRQTIATADHRAPHHSVAVAATEVALPSAQNQTTDVSVYNHDFQHIVPLEVKEALQRNMRPICEDDDDDDDDALLHDGLSAPTPPPLTSFANVTHSMYEDTCHLDTPSNYVRTRGTGSVGGAGTEIADAPFSFPPSTLHAPSRLFASPNAPALQTATSSMIAWQTGGTGGAKSIRPFDSDTAETLAAGLSISGTGVPFQAWKFPSLGKPNSASSLRKTSLGENGNAEALPEGAVGGAAAVHQPTVPLSEHCSHPTRETLMPGSPQRQCSESPPLTRNGLQATSKHITLKTAATPCSSVAVGALSGSGDVGPRAASLLSGVDGTHRTSSVVHGTPMRTNDGAGGRFVQPAVAQGSPSSAAGSLSAAADSSNTRKLEMMYTVYERLLHARPPDNSFPEATPRSLQTLTSRSLTEEVTPPLDTSPSPPAAQQAPQSGAAGAGFEAMSQGDCSPSMSYSGALSRSAGYYSFGKRISLSHPNKQTLPHQFLGSAANLHAMSSPPRVAMIGTPAVADMIVASNGNSSGSAMAFSSTARARRRTLDLSVLQRIDSRPLLQSTLFLQNNLHSICEAQARFARKERAEDAGSAEQRNAISLSPSKAAVSVAVKPVPQYTVPLEEQSAAGVPSPASVADVETCEGVEGVSQGRMTGRTAIAETASPVVLGSAAASATAASTARELNQTRSSCRGTQVPSVDSVLPSSVSPSIGKRSNASSLPVNCIQEGQGRQEEPLRKQAEMHVNPTAAAAVSVAHESNGISPHRYYRALTEAKCLVRHVHGVDGVEREVDNDSMDLVVYAGMHLMGWLEVVSLLGCGSFGQVFLCKDLRICDGHFVHPSEIEGEDYEYWNCSHAYLPFSSVDAVPTHRPLVAVKVVKSVPLLEQQSVLEAEMLVLIGAQTALPPANAAEEARESAIPAFAAATGGRIGVNEPPPADPRCANIAKVLADGICYGHHCIVMERYGANLYEYIAANDHRGLPMYQIRSIGAQLFSALSLVHEECHIIHADIKPENVLLTLDSGRGTLRVTDEPSPITAATAAATPPAEAMSNSNASTTAVATKTPRSVPQQNAFAEAAHRSPSSTSPNAEPPWHQQRTESAASSSASPSLPAERSHTARVGPGAVARQRLGFKGKRRNSNTLLDLSSSPMTLATYKGHSLCHLRSSSASRATIVEQTDMPTPEPRRMHMLSQSSALVTSAASGMSLQSLGGGGAGSYSRHMMQAPAAPVEEAPAVPVAPAASHLHVRLIDFSSSCYDGGPFYQYIQSRYYRAPEVIIGAPYNSAIDVWSTGCLLAELLLGMPLLPGCNDHHQLSLVEEMIEPLPDYLVEDGDNADLFYIVAAPGGEGSTDAALPRAPAAAAPGATASATLQQPRSFALRTRENYLEVTGSEPLQYRRYFTYQTLQELVRHCPLTLEERRMSNGLHPYVSANESSAIPPDATPSLSVRSDMMKQRYLLFDLLRRLLQTDSKLRPTAAQALQHPFFSSLPPYFKTFALD
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290.--.....1300......1310.----.------....1320...-...1330....--..1340......1350......1360.-.....1370......1380......1390.------.....1400......1410......1420......1430......1440-.........1450......1460......1470......1480......1490......1500......1510......1520......1530......1540......1550..---....1560......1570.--.....1580......1590------.......1600--------.......1610-.......1620......1630......1640.......1650......1660......1670......1680......1690........1700......1710-----.......1720......1730.......1740......1750......1760......1770......1780......1790......1800......1810......1820......1830......1840......1850.....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MPSSN
L
V
T
DAYHN
T
E
L
A
I
N
V
F
F
S
I
HTDANPVMGRKATKA
S
V
V
P
I
A
A
S
LLPA
N
A
A
V
M
IDDDLTPGVADFGATTEPAVRS
P
S
S
V
E
R
E
V
F
E
N
S
I
A
DIGG
G
G
A
L
S
Q
S
V
V
S
RRDM
S
L
A
D
I
S
R
M
R
L
E
GCRAR
H
T
L
F
A
A
T
T
S
L
R
G
S
M
A
S
S
L
RSTSGSPMLPLTGRVRDHAGICGE
T
T
S
A
A
I
S
A
V
SQAPAW
S
S
L
N
G
L
G
R
SFNRR
S
S
M
L
S
VRTNAL
D
T
S
I
A
I
L
Q
H
M
AH
D
T
A
A
R
A
E
AACNAQSLAGTPSTATSACGSVALPSLQPTQPYPEDTHAGAR
G
Y
K
V
VGSGNTASVEDSCSGSGQH
T
P
V
L
H
T
V
H
T
R
QFTSASDSSSP
L
N
SL
S
E
S
E
L
C
S
G
H
LRAGGRSHLSAQAS
A
T
H
LTGSGG
V
A
K
A
A
S
D
LQHSSPRSHPDGS
P
L
A
A
R
R
Q
T
IATADHRAPHH
S
V
A
V
A
A
T
E
VALPSAQNQT
T
D
V
S
V
YNHDFQHI
V
P
L
E
V
K
E
A
L
Q
RNMRPICEDDDDDDD
D
A
L
L
HDGLSAPTPPP
L
T
S
F
A
N
V
T
H
S
M
Y
EDTCHLDTPSN
Y
V
R
TRGTGSVGGAGTEIADAPFSFPPSTLHA
P
S
R
LFASPNAP
A
L
Q
T
ATS
S
M
I
A
W
QTGGTGGAKSIRPFDS
D
T
A
E
T
L
A
AG
L
S
ISGTGVPFQAWKFPSLGKPNSASS
L
R
KTSLGENGNAEALPEGAVGGAAAVHQPTV
P
L
S
E
HCSHP
T
R
ETLMPGSPQRQCSESPPLTRNGLQATS
K
H
I
T
L
K
TAATPCS
S
V
A
V
G
A
LSGSGDV
G
P
R
A
A
S
L
L
SGVDGTHRTSSVVHGTPMRTNDGAGG
R
F
VQPAVAQGSPSSAAGSLSAAADSSN
T
R
K
L
E
M
M
Y
T
V
Y
E
R
L
LHARPPDNSFPEAT
P
R
S
L
Q
T
L
T
S
RS
L
T
E
EVTPPLDTSPSPP
A
A
QQAPQSGAAGAG
F
E
AMSQGDCSPSMSYSGALSRSAGYYSFG
K
R
I
SLSHPNKQTL
P
H
Q
F
L
GSAANLHAMSSP
P
R
V
A
M
IGTPA
V
A
D
M
I
V
ASNGNSSGS
A
M
A
F
S
S
T
A
R
A
RRRTL
D
L
S
V
L
Q
R
IDSR
P
L
L
Q
S
T
L
F
L
Q
N
N
L
H
S
I
C
E
A
Q
A
R
F
A
R
K
E
RAEDAGSAEQR
N
A
I
SLSPS
K
A
A
V
S
V
A
V
KPVPQYTVPLEEQSAAGVPSPASVAD
V
E
TCEGV
E
G
V
SQGRMTG
R
T
A
IAETAS
P
V
V
L
GSAAASA
T
A
A
S
T
A
R
E
L
N
Q
T
R
S
SCRGTQVP
S
V
D
SVLPSSVSPSIGKRSNASSL
P
V
N
C
I
QEGQGRQ
E
E
P
L
R
K
Q
A
EMHVNPTA
A
A
A
V
S
V
AHESNGI
S
P
H
R
Y
Y
R
A
L
T
E
A
K
C
L
V
R
H
V
HGVDGVEREVDNDSM
D
L
V
V
Y
A
G
M
H
L
M
G
W
L
E
V
V
S
L
LGCGSFG
Q
V
F
L
CKDLRICDGHFV
H
P
S
EIEGEDY
E
Y
WNCSHAYLPFSSVDAVPTHR
P
L
V
A
V
K
V
V
K
SVPL
L
E
Q
Q
S
V
L
E
A
E
M
L
V
L
IGAQTALPPA
N
A
A
E
E
A
R
E
SAI
P
A
F
AAATGGRIGVN--EPPPAD
P
R
C
A
N
I
A
K
V
L
ADGI----C------YG
H
H
C
I
V
M
E
R
Y-G
A
N
L
Y
E
Y
I
AAN--DHRGL
P
M
Y
Q
I
R
S
I
G
A
Q
L
F
S
A
L
S
L
V
H
EE-
C
H
I
I
HADIKPE
N
V
L
L
T
L
DSGR
G
T
L
R
VTDEP------SPITAATAAATP
P
A
E
AMSNSNAS
T
T
A
V
ATKTPRSVPQ
Q
N
A
F
A
E
A
AH----RSPSSTSPNAEPP
W
H
Q
Q
R
T
E
SAASSSASPSLPAERSHTARVG
P
G
A
V
A
R
Q
R
LGFKGKRRNS
N
T
L
L
DLSSS
P
M
T
L
A
TYKG
H
S
L
C
H
LRSSSAS
R
A
T
I
V
EQTDMPTP
E
P
R
R
M
H
M
LSQSS---
A
L
V
T
SAASG
M
S
L
Q
SLGGGG--A
G
S
Y
S
R
H
M
MQAPAAPVEE-------APAVPVAPAA---------
S
H
L
H
V
R
L
I
DF--SSSCYDG
G
P
F
Y
Q
Y
I
Q
S
R
YYRAP
E
V
I
I
GAPY-NSA
I
D
V
W
S
T
G
C
L
L
A
E
L
L
LGMPLLPGCND
H
H
Q
L
S
L
V
E
E
M
I
E
P
L
P
D
Y
L
VE--DGDNA
D
L
F
Y
I
V
AAPGGEGSTDA------ALPRAPAAAAPGATA
S
A
T
L
Q-Q
P
R
S
F
A
L
RTRE
N
Y
L
E
VTGSEP
L
Q
Y
R
R
Y
F
T
Y
Q
T
L
Q
E
L
V
R
HCPL
T
L
E
E
R
R
MSNGLHPYVSANESSAIPPDATPS
L
S
V
R
S
D
M
M
K
Q
R
Y
L
L
F
D
L
L
R
R
L
L
QTDSKLR
P
T
A
A
Q
A
L
QH
P
F
F
SSL
P
P
Y
F
K
T
FALD
51
Fugue
73.59
17%
-
- C1 -
-
3H4J
-
SNF1_SCHPO
B:
[27-356]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
R
H
I
G
P
Y
I
I
R
E
-
T
L
G
E
G
S
F
G
K
V
K
L
A
T
H
Y
K
T
Q
Q
K
V
A
L
K
F
I
S
R
Q
L
L
K
K
S
D
M
H
M
R
V
E
R
E
I
S
Y
L
K
L
L
R
H
P
H
I
I
K
L
Y
D
V
I
T
T
P
TDI
V
M
V
I
E
Y
A
G
G
E
L
F
D
Y
I
V
E
K
K
RM
T
E
D
E
G
R
R
F
F
Q
Q
I
I
C
A
I
E
Y
-------
C
H
R
H
K
I
V
H
R
D
LKPENLLLD
D
N
L
N
V
K
I
A
D
F
GL
S
N
I
M
T
D
G
N
F
L
K
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
N
G
K
L
Y
A
G
P
E
V
D
V
W
S
C
G
I
V
L
Y
V
M
L
V
G
R
L
P
F
D
D
E
F
I
P
N
L
F
K
K
V
N
S
C
V
Y
V
M
P
D
F
L
S
P
--
G
A
Q
S
L
I
R
R
M
I
V
A
D
P
M
Q
R
I
T
I
Q
E
IRRDPW
F
N
V
N
L
P
D
Y
L
R
P
M
E
E
V
Q
G
S
Y
A
D
S
R
I
V
S
K
L
G
E
A
M
G
F
S
E
D
Y
I
V
E
A
L
R
S
D
E
N
N
E
V
K
E
A
Y
N
L
L
H
E
N
Q
V
I
Q
E
K
L
E
H
H
H
---------------------------------------------------------------------------
25
HHSearch
72.89
30%
-156
- C1 -
-
4YU2
2
DYR1A_HUMAN
A:
[12-173]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
N
D
G
Y
D
D
D
N
Y
D
Y
I
V
K
N
G
E
K
W
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
R
V
E
-------------------------------------
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
-------------------------------------
D
T
E
M
K
Y
Y
I
V
H
L
K
R
H
F
M
----
F
------
R
N
H
L
C
L
V
F
E
M
L
-
S
Y
N
L
Y
D
L
L
R
N
T
--
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
P
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
72.00
33%
0
- C- -
-
5MY8
11
?
A:
[13-189]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
V
K
I
G
D
L
F
N
G
R
Y
H
V
I
R
K
L
G
W
G
H
F
S
T
V
W
L
S
W
D
I
Q
G
-------------------------------------
K
K
F
V
A
M
K
V
V
K
S
A
E
H
Y
T
E
T
A
L
D
E
I
R
L
L
K
S
V
R
-----------------------------------
N
S
D
P
N
D
P
N
R
E
M
V
V
Q
L
L
D
D
F
K
I
S
G
V
N
------
G
T
H
I
C
M
V
F
E
V
L
-
G
H
H
L
L
K
W
I
I
K
S
--
N
Y
Q
G
L
P
L
P
C
V
K
K
I
I
Q
Q
V
L
Q
G
L
D
Y
L
H
T
K
-
C
R
I
I
H
T
D
I
K
P
E
N
I
L
L
S
V
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
68.61
30%
-156
- C1 -
-
4YLL
8
DYR1A_HUMAN
A:
[12-179]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
N
D
G
Y
D
D
D
N
Y
D
Y
I
V
K
N
G
E
K
W
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
R
V
E
-------------------------------------
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
-------------------------------------
D
T
E
-
K
Y
Y
I
V
H
L
K
R
H
F
M
----
F
------
R
N
H
L
C
L
V
F
E
M
L
-
S
Y
N
L
Y
D
L
L
R
N
T
--
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
P
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
68.21
30%
-175
- C1 -
-
1Z57
1
CLK1_HUMAN
A:
[2-157]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
------------------------------------
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
-----------------------------------
T
--
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
----
H
------
H
G
H
I
C
I
V
F
E
L
L
-
G
L
S
T
Y
D
F
I
K
E
N
--
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
--
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
67.07
30%
-164
* C1 *
-
2EU9
1
A:
[5-159]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
------------------------------------
G
K
S
Q
V
A
L
K
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
-------------------------------------
D
K
E
N
K
F
L
C
V
L
M
S
D
W
F
N
----
F
------
H
G
H
M
C
I
A
F
E
L
L
-
G
K
N
T
F
E
F
L
K
E
N
--
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
E
N
--
Q
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
66.62
31%
-169
- C1 -
-
3LLT
1
?
A:
[20-172]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
I
V
H
F
S
W
K
K
G
M
L
L
N
N
A
F
L
V
I
R
K
M
G
D
G
T
F
G
R
V
L
L
C
Q
H
I
D
N
-------------------------------------
K
K
Y
Y
A
V
K
V
V
R
N
I
K
K
Y
T
R
S
A
K
I
E
A
D
I
L
K
K
I
Q
N
--------------------------------------
D
D
I
N
N
N
N
I
V
K
Y
H
G
K
F
M
----
Y
------
Y
D
H
M
C
L
I
F
E
P
L
-
G
P
S
L
Y
E
I
I
T
R
N
--
N
Y
N
G
F
H
I
E
D
I
K
L
Y
C
I
E
I
L
K
A
L
N
Y
L
R
K
M
--
S
L
T
H
T
D
L
K
P
E
N
I
L
L
D
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
66.04
30%
-156
- C1 -
-
4AZF
1
DYRK2_HUMAN
A:
[83-237]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
H
K
V
-------------------------------------
H
Q
H
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
-------------------------------------
D
K
D
N
T
M
N
V
I
H
M
L
E
N
F
T
----
F
------
R
N
H
I
C
M
T
F
E
L
L
-
S
M
N
L
Y
E
L
I
K
K
N
--
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
H
K
N
--
R
I
I
H
C
D
L
K
P
E
N
I
L
L
K
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
65.16
29%
-144
- C1 -
-
5LXC
6
DYRK2_HUMAN
A:
[59-214]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
H
K
V
-------------------------------------
H
Q
H
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
-------------------------------------
Q
D
K
D
N
T
M
N
V
I
H
M
L
E
N
F
T
----
F
------
R
N
H
I
C
M
T
F
E
L
L
-
S
M
N
L
Y
E
L
I
K
K
N
--
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
H
K
N
--
R
I
I
H
C
D
L
K
P
E
N
I
L
L
K
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
65.14
30%
-168
- C1 -
-
5J1W
5
CLK1_HUMAN
A:
[2-153]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
------------------------------------
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
-------------------------------------
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
----
H
------
H
G
H
I
C
I
V
F
E
L
L
-
G
L
S
T
Y
D
F
I
K
E
N
--
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
--
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
53.21
26%
-79
- C1 -
-
1J1B
1
GSK3B_HUMAN
B:
[54-202]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-------------------------------------
G
E
L
V
A
I
K
K
V
L
Q
D
K
---
R
F
K
N
R
E
L
Q
I
M
R
K
L
-------------------------------------------
D
H
C
N
I
V
R
L
R
Y
F
F
Y
----
S
S
GEKKD
E
V
Y
L
N
L
V
L
D
Y
V
-
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
--
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
--
T
A
V
L
K
L
C
D
F
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
Fugue
52.54
15%
-9
- C1 -
-
5KCV
1
AKT1_HUMAN
A:
[20-452]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
K
E
G
W
L
H
K
R
G
E
Y
I
T
W
R
P
R
Y
F
L
L
K
N
D
-
G
T
F
I
G
Y
K
E
R
P
A
P
L
N
N
F
S
V
A
Q
C
Q
L
M
K
T
E
R
P
R
P
N
T
F
I
I
R
C
L
Q
W
T
T
V
I
E
R
T
F
H
V
E
T
P
E
E
R
E
E
W
T
T
A
I
Q
R
-
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
T
G
R
Y
Y
A
M
K
I
L
K
K
V
L
Q
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
----
T
------
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
----
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
-
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
---
G
H
I
K
I
T
D
F
G
LCPEYL
A
P
E
V
L
E
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
E
K
L
F
E
L
I
L
MEEI
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
S
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
52.36
41%
-121
- C2 -
-
3ANR
1
DYR1A_HUMAN
A:
[181-278]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
I
V
D
F
--
G
S
S
C
Q
L
G
Q
R
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
-
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
--
Q
A
P
K
A
R
K
F
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
52.14
56%
-135
- C2 -
-
3K2L
-
DYRK2_HUMAN
A:
[241-315]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
V
I
D
F
--
G
S
S
C
Y
E
H
Q
R
V
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
R
Y
-
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
51.90
24%
-129
- C1 -
-
1TKI
-
TITIN_HUMAN
A:
[20-165]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Y
E
K
Y
M
I
A
E
D
L
G
R
G
E
F
G
I
V
H
R
C
V
E
T
S
S
-------------------------------------
K
K
T
Y
M
A
K
F
V
K
V
K
G
T
D
Q
V
L
V
K
K
E
I
S
I
L
N
I
-------------------------------------------
A
R
H
R
N
I
L
H
L
H
E
S
F
E
----
S
------
M
E
E
L
V
M
I
F
E
F
I
S
G
L
D
I
F
E
R
I
N
T
S
--
A
-
F
E
L
N
E
R
E
I
V
S
Y
V
H
Q
V
C
E
A
L
Q
F
L
H
S
H
--
N
I
G
H
F
D
I
R
P
E
N
I
I
Y
Q
T
R
-
R
S
S
T
I
K
I
I
E
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
51.21
41%
-124
- C2 -
-
5AIK
1
DYR1A_HUMAN
A:
[200-295]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
I
V
D
F
--
G
S
S
C
Q
L
G
Q
R
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
-
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
--
Q
A
P
K
A
R
K
F
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
Fugue
51.20
11%
-15
- C1 -
-
1TKI
-
TITIN_HUMAN
A:
[18-338]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
L
Y
E
K
Y
M
I
A
E
D
L
G
R
G
E
F
G
I
V
H
R
C
V
E
T
S
S
K
K
T
Y
M
A
K
F
V
K
V
K
G
T
D
Q
V
L
V
K
K
E
I
S
I
L
N
I
---
A
R
H
R
N
I
L
H
L
H
E
S
F
E
S
M
E
E
L
V
M
I
F
E
F
I
S
---
G
L
D
I
F
E
R
I
N
T
S
A
F
E
L
N
E
R
E
--
I
V
S
Y
V
H
Q
V
C
E
A
L
Q
F
L
H
S
H
NIGHFDI
R
P
E
N
I
I
Y
Q
T
R
---------
R
S
S
T
I
K
I
I
E
F
GQ
A
R
Q
L
K
P
G
D
N
F
R
L
L
F
T
A
P
E
Y
Y
A
P
E
V
H
Q
H
D
V
V
-
S
T
A
T
D
M
W
S
L
G
T
L
V
Y
V
L
L
S
G
I
N
P
F
L
A
E
T
N
Q
Q
I
I
E
N
I
M
N
A
E
Y
T
F
D
E
E
A
F
K
EI
S
I
E
A
M
D
F
V
D
R
L
L
V
K
E
R
K
S
R
M
T
A
------
S
E
A
L
Q
H
P
W
L
K
Q
K
I
E
R
V
S
T
K
V
-
I
R
T
L
K
H
R
R
Y
Y
H
T
L
I
K
K
D
L
N
M
V
V
S
A
A
R
I
S
C
G
G
A
I
R
S
Q
K
G
V
S
V
A
K
V
K
V
A
S
I
-----------------------------------------------------------------------------
20
PsiBlast_PDB
51.05
41%
-133
* C2 *
-
5A4E
1
DYR1A_HUMAN
A:
[181-278]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
I
V
D
F
--
G
S
S
C
Q
L
G
Q
R
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
-
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
--
Q
A
P
K
A
R
K
F
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
50.59
41%
-125
- C2 -
-
5A3X
1
DYR1A_HUMAN
A:
[181-278]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
I
V
D
F
--
G
S
S
C
Q
L
G
Q
R
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
-
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
--
Q
A
P
K
A
R
K
F
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
50.43
56%
-141
- C2 -
-
4AZF
1
DYRK2_HUMAN
A:
[241-317]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
V
I
D
F
--
G
S
S
C
Y
E
H
Q
R
V
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
R
Y
-
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------