@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_19_0590: (2018-03-09 )
MLPSSAPPWGPGPHDPAPYSTIAAHNCTAECVDGPTSGSATHNRSTSPRGQPAGGDTASPTPASVEVLGRKTQHRRCSTSPPLKPLMKEAVLARALEKPRCTLASAAMESTGDPPHPSKDSDAETSACIRATCTGSRTRVDHAPPLSLSATVSSVQQHLGMIPQVASSNSASYQASASAPSTPSNRKEASKMQRRSSSAFMSRLPSDTRLRTSLLAAFGVQHAETHGRCDAPSHAPLPVRGSLSMTNSTDVTPVASDTHFRRSVNEGCSTVESHCTATAAASCVVVRAPSGAFRALPHPSIWLNTSLAGIGGVPSFNSSTPSTNASVLKDRHSSGTGTCEVPSESSLLPPFRTSSLDRDGVGAEDCGSEASGTASTSATVEVLHSGDANPVTGDRCSRLPSGRSINTSVSGEVGGFAPDASGTSTAHHTCAESNSSAGGGAELQGAGCSFGWRMFSSLTSQRGGGGGGAPAPSLGIFQSGLYLSMDEGDVSPAPALEVPMTPQSFSTMLLARESSEGAQHPVRAGSATSATTTNGARSSSLAVQEGNDTMLRQSSQQVPIVSQLAEDAWSGGGVAANGIEDWCVDGGSRDSREARTTSTTHTSGVGSHPCLVPGSGSGRCVIGGCCATPLSSFQLLGGSSKQEMPTSALDTDEIPSTPTDISALPYPPPPPLSARRRRQRRACHHCDGGNAVSSNSRVDLETGVIETDTLERARAVSKDGSRAYEIVNGKYVMYDYELGRGSYATVRLCYNLADGHFYAVKVLDRVRLKRRQLGSEAGLCKIDQEIAMMKQVQHKNIIALHEVIRDPSMRYVYLVLELAESREVLSMRDNGDVLPRGDDDGAATAYPEAAAREMVKGLLQALMYIHYLGVAHRDIKPSNVLRTADGTVKLCDFGVSVLVGDAPMQLSREGSVAFLAPELLLSSEVEVSRFLTPDDSSLGSTRNKSATHMLADSALATATRNARTTVTSTTTATSATELASTGGPASPKEEGAKWTQRLMSSFAGAALQPNARAAASRAPGREIASPGGGAPSAIPPWPSSASLPKRGGGGGAARRASFRTLSLSPCGAAARECAAAIATAAVSPCAGGAAAVTPPTGAYSPSTPAAQPFSDLSKSAGNAPVDLLKADVFALGVTVYTLLLGHLPWRASSAVSQRAAILAEPDPFLRLYKAAYGDAYVGPPQVREACMPRCDVLGSDAIPASSHASTSASGKDGRGASYGTANAELSDGQWAIAAEKDDVVTPAPVTALPCKWRHLSNTGTTPDECTSEQEKCTPTAAKLTAAPQPHRNAPTRSDRNSAQPVGERSTAAAALPRPATQLLAKKATTSESRAPKDLAESPSDDHNPRAPFEAPPPPMPPQQERHLHRFQWRPFMDVVLGSAPIKTATAAGTAITQQAQVTVRHRRGGGGELVDGDLRQTNATTTCIRSRAPAVKMLLSRAATQPRFGSVVQVPHSLAICGDERATWEAQGAAMSGPAVAPPLRPRGPTTTPDQLYPYRGILDVDDDDWMKADESDVVQGMKESAINAEQWVPGSSSDLLRTVPSSAVTGTRSNDSEADSASDCDSSTTTVPCSAAKSTASSLPSDDDEDLESCESIYERLFEMEQPCRAYTVVEHMPLPTMSGTSREISGEAVDFVRSCLCLDPAERRTVFELFRHPWIRGGEGAMLAEAGTSAGSP
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770-------........780------.........790.-..-.....800.......810.......820.......830.......840.......850.......860.......870.......880--.---..--.---.----.-..890.......-900-........-910.......920.---......930.......940.......950......---.--960.......970.......980..-.....990.......1000.....--.1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110..-----------....1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320......1330......1340......1350......1360......1370......1380......1390......1400......1410......1420......1430......1440......1450......1460......1470......1480......1490......1500......1510......1520......1530......1540......1550......1560......1570......1580......1590......1600......1610......1620......1630......1640......1650......1660......1670..
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MLPSSAPPWGPGPHDPAPYSTIAAHNC
T
A
E
CVDGPTSGSATHNRSTSPRGQPAGGDTASPTP
A
S
V
E
V
LGRKTQHRRCSTSP
P
L
K
P
L
M
K
E
A
V
L
A
R
A
LEKPR
C
T
L
A
S
A
A
M
ESTGDPPHPSKDSDAETS
A
C
I
R
A
TCTGSRTRVDHAPPL
S
L
S
A
T
V
S
S
V
Q
Q
H
LGMIPQVASSNSASYQASASAPSTPS
N
R
K
E
A
S
K
M
Q
R
R
S
S
S
A
F
M
S
RLPS
D
T
R
L
R
T
S
L
L
A
A
F
GVQH
A
E
THGRCDAPSHAPLPVRGSLSMTNSTDVTPVAS
D
T
H
F
R
R
S
V
N
E
G
C
S
T
V
E
S
HCTATAA
A
S
C
V
V
V
RAPSGAFRALPHP
S
I
W
L
NTSLAGIGGVPSFNSSTPST
N
A
S
V
L
K
DRHSSGTG
T
C
EVPSESSLLPPFRTSSLDRDGVG
A
E
DCGSEASGTAST
S
A
T
V
E
V
L
HSGDANPVT
G
D
R
C
SRLPSGRSINTSVSGEVGGFAPDASGTST
A
H
H
T
CAESNSSAGGGA
E
L
QGAGC
S
F
G
W
R
M
F
S
S
L
T
SQRGGGGGGAPAP
S
L
G
I
FQS
G
L
Y
L
SMDEGDVSPAPALEVPMT
P
Q
S
F
S
T
M
L
L
ARESSEGAQHPVRAGSATSATTTNGARSS
S
L
A
VQEGN
D
T
M
L
RQSSQQV
P
I
V
S
Q
L
A
E
D
AWSGGGVAANG
I
E
D
W
CVDGGSRDSREARTTSTTHTSGVGSHPCLVPGSGSG
R
C
V
I
GGCCATP
L
S
S
F
Q
LLGGSSKQEMPTSALDTDEIPSTPTDISALPYPPPPP
L
S
A
R
R
R
R
Q
R
R
ACHHCDGGNAVSSN
S
R
V
D
L
ETGVIE
T
D
T
L
E
R
A
R
AVSKDG
S
R
A
Y
E
I
VNG
K
Y
V
M
Y
D
Y
ELGRG
S
Y
A
T
V
R
L
C
Y
NLADGH
F
Y
A
V
K
V
L
D
R
V
R
L
K
R
R
--------QLGSEAGL
C
--------
K
I
D
Q
E
I
A
M
M
K
Q
-
V
-
Q
H-
K
N
I
I
A
L
H
E
V
IRDPS
M
R
Y
V
Y
L
V
L
E
L
AESR
E
V
LSMRDNGDVLPRGDDDGAATAY
P
E
A
A
A
R
E
M
V
K
G
L
L
Q
A
L
M
Y
I
H
Y
LGVAHRDIKPSN
V
L
---R---TA--D---G----
T
-
V
K
L
CDFG
V
S
V
L
V-G-D-AP
M
Q
LSRE-G
S
V
A
F
L
A
P
E
L
L
LSS---E
V
E
V
S
R
F
LTPDDSSLGSTRNKS
A
T
H
M
L
A
D
S
A
L
A
T
A---T--RNA
R
T
T
V
T
STTTAT
S
A
T
E
LASTGGP-AS
P
K
E
E
G
A
K
W
T
Q
R
L
M
S
S
FAGAALQ--PNARAAASRAPGREIASPGGGAPSAIPPWPSSASLPKRGGGGGAAR
R
A
S
F
R
T
L
SLSP
C
G
A
A
A
R
E
C
A
A
A
I
A
T
A
AVSPCAGGAAAVTPPTGAYSPSTPAAQ
P
F
S
D
L
S
K
S-----------AGNA
P
V
D
L
L
K
A
D
V
F
A
L
G
V
T
V
Y
T
L
L
L
GHLPWRA
S
S
A
V
S
Q
R
A
A
ILAEP
D
P
F
L
R
L
Y
K
A
AYGDAYVG
P
P
Q
V
R
E
A
C
M
P
R
C
DVLGSDAIPASSHASTSASGKDGRGASYGTANAELSDG
Q
W
A
I
AAEKDDVVTPAPVTALP
C
K
W
R
HLSNTGT
T
P
D
E
CTS
E
Q
EKCTP
T
A
A
KLTAAPQPHRNAPTRSDRNSAQPVGERSTAAAALPR
P
A
T
Q
L
L
A
KKATTSESRA
P
K
D
LAESPSDDHNPRAPFEAPPPPMP
P
Q
Q
E
R
H
L
H
R
FQWR
P
F
M
D
V
VLGSAPIKTATAAGT
A
I
T
Q
Q
A
Q
V
T
V
R
H
RRGGGGELVDGDLRQTNA
T
T
T
C
I
RSRA
P
A
V
K
M
L
L
S
R
AATQPRFGS
V
V
QVP
H
S
L
A
ICGDERATWEAQGAAMSGPAVAPPLRPRGPTTTPDQLYPYRGILDVDD
D
D
WMKA
D
E
S
D
V
V
Q
G
M
K
E
SAI
N
A
E
QWVPGSS
S
D
L
L
R
TVPSSAVTGTRSNDSEADSASDCDSST
T
T
V
PCS
A
A
K
S
T
A
SSLPSD
D
D
E
D
L
E
S
C
E
S
I
Y
E
R
L
F
E
MEQPCR
A
Y
T
V
VEHMPLPTMSGTSREIS
G
E
A
V
D
F
V
R
S
C
LCL
D
P
A
E
R
R
T
V
F
E
L
F
RHPWIRGGEG
A
M
L
A
EAGTSAGSP
57
Fugue
62.79
14%
-
- C1 -
-
3QA8
-
?
A:
[16-666]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
K
E
R
L
G
T
G
G
F
G
Y
V
L
R
W
I
H
Q
D
T
G
E
Q
V
A
I
K
Q
C
-------
R
--------
Q
E
L
S
P
K
N
R
E
--------
R
W
C
L
E
I
Q
I
M
K
K
-
L
-
N
H
-
P
N
V
V
S
A
R
E
V
P
D
G
L
Q
K
L
A
P
N
D
L
P
L
L
-----
A
M
E
Y
C
E
G
G
D
L
R
K
Y
L
N
Q
F
E
N
C
C
G
L
K
E
G
P
I
R
T
L
L
S
D
I
S
S
A
L
R
Y
L
H
E
N
R
I
I
H
R
D
L
K
P
E
N
I
V
---
L
QPG
P
Q
--
R
---
L
----
I
-
H
K
I
I
D
L
G
Y
A
K
E
L
-
D
-
Q
-
G
E
L
C
T
E
F
V
-
G
T
L
Q
Y
L
A
P
E
L
L
E
Q
K
---
K
Y
T
V
----
T
V
D
Y
W
S
F
G
T
L
A
F
E
C
I
T
G
F
R
P
F
L
P
N
W
Q
P
---
V
--
Q
W
H
G
K
V
R
I
V
V
Y
D
D
L
T
G
A
V
K
F
S
S
V
L
P
-
T
P
N
H
----------
L
S
G
I
L
A
G
K
L
E
--
R
W
L
Q
C
M
L
M
W
H
Q
R
T
D
P
Q
N
P
N
V
G
C
F
Q
A
L
D
S
I
L
S
L
K
L
L
S
V
M
-----
N
M
V
S
G
R
V
H
T
Y
P
V
T
E
-
N
E
N
L
Q
N
L
K
S
W
L
Q
Q
D
T
G
I
P
-
E
E
E
Q
E
L
L
Q
A
S
G
L
A
L
N
S
A
Q
P
L
T
Q
Y
V
I
D
C
T
V
G
D
L
I
F
L
F
DNRKI
S
L
P
A
H
P
E
S
V
S
I
V
L
Q
D
P
K
R
P
L
T
Y
T
H
L
R
R
V
W
G
Q
I
W
Q
T
I
R
A
L
K
E
D
C
A
R
L
L
Q
G
Q
R
T
S
M
V
N
L
L
R
Y
N
T
E
L
S
K
K
K
N
S
M
T
S
E
C
E
Q
L
K
A
K
L
D
F
F
R
S
S
I
Q
I
D
L
E
K
Y
S
E
Q
-
M
E
F
G
I
T
S
E
K
L
L
S
A
W
R
E
M
E
Q
A
V
E
L
C
G
R
E
R
E
V
Q
A
L
V
D
K
M
M
A
L
Q
T
D
S
V
D
L
Q
R
N
P
T
L
D
D
L
E
E
Q
A
R
D
L
Y
R
R
L
R
E
R
P
R
D
Q
R
T
P
G
D
S
N
D
M
V
R
L
L
I
L
A
I
Q
S
F
E
K
R
V
I
L
I
Y
D
Q
L
S
K
T
V
V
C
K
R
K
A
L
E
L
S
P
K
V
K
E
V
M
N
L
M
R
E
D
E
K
I
V
V
R
R
Q
E
K
R
Q
Q
E
L
W
N
L
L
K
I
A
C
S
K
V
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
HHSearch
62.52
25%
-56
- C1 -
-
4B4L
3
DAPK1_HUMAN
A:
[12-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
Y
Y
D
T
G
-
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
--------
R
--
R
G
V
S
R
E
--------
D
I
E
R
E
V
S
I
L
K
E
-
I
-
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
--
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
------------
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
---
L
---
L
D
--
R
---
N
VP
K
P
R
-
I
K
I
I
D
F
G
L
A
H
K
I
-
D
-
F
-
G
N
E
F
K
N
I
F
-
G
T
P
E
F
V
A
P
E
I
V
N
Y
-----
E
-
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
---
E
--
T
L
A
N
V
S
--------------
A
V
N
Y
E
-
F
E
-
D
E
Y
F
S
N
T
S
-
A
L
A
K
D
F
I
R
R
L
L
V
KD
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
Fugue
62.49
19%
-41
- C1 -
-
4DN5
7
M3K14_HUMAN
A:
[8-351]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
E
E
Y
L
V
H
A
L
Q
G
S
V
S
S
G
Q
A
H
S
L
T
S
L
A
K
T
W
A
A
R
G
S
R
S
R
E
P
S
P
K
T
E
D
N
E
G
V
L
L
T
E
K
L
K
P
V
D
Y
E
Y
R
E
--
E
V
H
W
A
T
H
Q
L
R
L
G
R
G
S
F
G
E
V
H
R
M
E
D
K
Q
T
G
F
Q
C
A
V
K
K
V
R
L
E
V
F
R
A
-----------------------------
E
E
L
M
A
C
A
G
-
L
-
T
S
-
P
R
I
V
P
L
Y
G
A
V
R
E
G
P
--
W
V
N
I
F
M
E
L
L
E
G
G
S
L
G
Q
L
V
K
E
Q
G
C
L
P
------------
E
D
R
A
L
Y
Y
L
G
Q
A
L
E
G
L
E
Y
L
H
S
R
R
I
L
H
G
D
V
K
A
D
N
V
L
---
L
---
S
S
--
D
---
G
----
S
H
A
A
L
C
D
F
G
H
A
----------
V
C
L
Q
I
P
-
G
T
E
T
H
M
A
P
E
V
V
L
G
R
---
S
C
D
----
A
K
V
D
V
W
S
S
C
C
M
----
M
L
H
M
L
N
G
C
H
P
W
T
Q
---
F
--
F
R
G
P
L
C
L
K
I
A
S
E
P
P
P
V
R
E
I
P
P
S
C
A
P
-
L
T
A
Q
A
I
Q
E
G
L
R
K
E
P
I
H
R
V
S
A
A
E
L
G
--
G
K
V
N
R
A
L
Q
Q
V
G
G
L
K
S
P
W
R
G
E
Y
K
E
P
R
H
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
62.28
25%
-58
- C1 -
-
2X0G
-
DAPK1_HUMAN
A:
[11-278]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
Y
D
T
G
-
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
--------
R
--
R
G
V
S
R
E
--------
D
I
E
R
E
V
S
I
L
K
E
-
I
-
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
--
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
------------
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
---
L
---
L
D
--
R
---
N
VP
K
P
R
-
I
K
I
I
D
F
G
L
A
H
K
I
-
D
-
F
-
G
N
E
F
K
N
I
F
-
G
T
P
E
F
V
A
P
E
I
V
N
Y
-----
E
-
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
---
E
--
T
L
A
N
V
S
--------------
A
V
N
Y
E
-
F
E
-
D
E
Y
F
S
N
T
S
-
A
L
A
K
D
F
I
R
R
L
L
V
KD
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
61.99
21%
-85
- C1 -
-
3C0G
1
CSKP_HUMAN
B:
[23-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
V
Y
E
L
C
-
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
S
--------
P
---
G
L
S
T
E
--------
D
L
K
R
E
A
S
I
C
H
M
-
L
-
K
H
-
P
H
I
V
E
L
L
E
T
Y
S
S
--
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
--------
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
---
L
---
A
S
--
K
ENS
A
----
P
-
V
K
L
G
G
F
G
V
A
I
Q
L
-
G
-
E
S
G
L
V
A
G
G
R
V
-
G
T
P
H
F
M
A
P
E
V
V
K
R
-----
E
-
P
Y
G
K
P
-
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
K
E
R
---
L
--
F
--
E
G
-------------
I
I
K
G
K
Y
K
-
M
N
P
R
Q
-
W
S
H
I
S
-
E
S
A
K
D
L
V
R
R
M
L
M
LD
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
R
Y
A
Y
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
60.56
25%
-62
- C1 -
-
4XBR
1
INKA1_HUMAN (first)
A:
[96-360]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
N
F
-
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
Q
Q
----------------
R
R
E
--------
L
L
F
N
E
V
V
I
M
R
D
-
Y
-
Q
H
-
E
N
V
V
E
M
Y
N
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
-------------
T
R
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
---
L
---
T
H
--
D
---
G
----
R
-
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
-
E
-
V
P
R
R
K
S
L
V
-
G
T
P
Y
W
M
A
P
E
L
I
S
R
-----
L
-
P
Y
G
P
E
-
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
---
K
--
A
M
---------------
K
M
I
R
D
N
L
P
-
P
R
L
K
N
-
L
H
K
V
S
-
P
S
L
K
G
F
L
D
R
L
L
V
RD
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
A
K
A
G
P
P
A
S
I
V
P
L
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
60.44
21%
-83
* C1 *
-
3C0I
1
CSKP_HUMAN
A:
[23-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
V
Y
E
L
C
-
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
S
--------
P
---
G
L
S
T
E
--------
D
L
K
R
E
A
S
I
C
H
M
-
L
-
K
H
-
P
H
I
V
E
L
L
E
T
Y
S
S
--
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
--------
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
---
L
---
A
S
--
K
ENS
A
----
P
-
V
K
L
G
G
F
G
V
A
I
Q
L
-
G
-
E
S
G
L
V
A
G
G
R
V
-
G
T
P
H
F
M
A
P
E
V
V
K
R
-----
E
-
P
Y
G
K
P
-
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
K
E
R
---
L
--
F
E
--
G
-------------
I
I
K
G
K
Y
K
-
M
N
P
R
Q
-
W
S
H
I
S
-
E
S
A
K
D
L
V
R
R
M
L
M
LD
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
R
Y
A
Y
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
59.68
26%
-52
- C1 -
-
2BDW
-
KCC2D_CAEEL
A:
[12-280]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
D
V
K
-
E
E
L
G
K
G
A
F
S
V
V
R
R
C
V
H
K
T
T
G
L
E
F
A
A
K
I
I
N
T
K
K
L
S
A
R
--------------
D
F
Q
--------
K
L
E
R
E
A
R
I
C
R
K
-
L
-
Q
H
-
P
N
I
V
R
L
H
D
S
I
Q
E
--
E
S
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
------------
E
F
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
I
A
Y
C
H
S
N
G
I
V
H
R
N
L
K
P
E
N
L
L
---
L
---
A
S
--
K
---
A
KG
A
-
A
-
V
K
L
A
D
F
G
L
A
I
E
V
-
N
-
D
-
S
E
A
W
H
G
F
A
-
G
T
P
G
Y
L
S
P
E
V
L
K
K
-----
D
-
P
Y
S
K
P
-
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
H
---
R
--
L
Y
A
Q
I
K
---------------
A
G
A
Y
-
D
Y
P
S
P
E
W
D
T
V
T
-
P
E
A
K
S
L
I
D
S
M
L
T
VN
P
K
K
R
I
T
A
D
Q
A
L
K
V
P
W
I
C
N
R
E
R
V
A
S
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
57.33
24%
-31
- C1 -
-
2Y7J
1
PHKG2_HUMAN
C:
[95-364]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
D
P
K
-
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
V
T
A
E
R
L
S
--------
P
E
Q
L
E
E
V
R
E
--------
A
T
R
R
E
T
H
I
L
R
Q
-
V
A
G
H
-
P
H
I
I
T
L
I
D
S
Y
E
S
--
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
------------
V
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
---
D
D
--
N
---
M
----
Q
-
I
R
L
S
D
F
G
F
S
C
H
L
-
E
-
P
-
G
E
K
L
R
E
L
C
-
G
T
P
G
Y
L
A
P
E
I
L
K
C
S
MDE
T
H
P
G
Y
G
K
E
-
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
R
R
Q
I
---
L
--
M
L
R
M
---------------
I
M
E
G
Q
Y
-
Q
F
S
S
P
E
W
D
D
R
S
-
S
T
V
K
D
L
I
S
R
L
L
Q
VD
P
E
A
R
L
T
A
E
Q
A
L
Q
H
P
F
F
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
HHSearch
57.01
22%
-111
- C1 -
-
4JXF
2
PLK4_HUMAN
A:
[9-264]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
K
V
G
-
N
L
L
G
K
G
S
F
A
G
V
Y
R
A
E
S
I
H
T
G
L
E
V
A
I
K
M
I
D
K
K
A
M
Y
K
A
-------------
G
M
V
Q
--------
R
V
Q
N
E
V
K
I
H
C
Q
-
L
-
K
H
-
P
S
I
L
E
L
Y
N
Y
F
E
D
--
S
N
Y
V
Y
L
V
L
E
M
C
H
N
G
E
M
N
R
Y
L
K
N
R
V
-----------
K
P
F
S
E
N
E
A
R
H
F
M
H
Q
I
I
T
G
M
L
Y
L
H
S
H
G
I
L
H
R
D
L
T
L
S
N
L
L
---
L
---
T
R
--
N
---
M
----
N
-
I
K
I
A
D
F
G
L
A
T
Q
L
-
K
M
P
-
H
E
---------------------------------
S
D
V
W
S
L
G
C
M
F
Y
T
L
L
I
G
R
P
P
F
----
V
K
---
N
--
T
L
N
K
V
---------------
V
L
A
D
Y
-
E
M
P
----
S
F
L
S
-
I
E
A
K
D
L
I
H
Q
L
L
R
RN
P
A
D
R
L
S
L
S
S
V
L
D
H
P
F
M
S
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
56.40
25%
-71
- C1 -
-
5J5T
1
M4K3_HUMAN
A:
[6-266]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
I
-
Q
R
I
G
S
G
T
Y
G
D
V
Y
K
A
R
N
V
N
T
G
E
L
A
A
I
K
V
I
K
L
E
P
G
E
----------------
D
F
A
--------
V
V
Q
Q
E
I
I
M
M
K
D
-
C
-
K
H
-
P
N
I
V
A
Y
F
G
S
Y
L
R
--
R
D
K
L
W
I
C
M
E
F
C
G
G
G
S
L
Q
D
I
Y
H
V
T
------------
G
P
L
S
E
L
Q
I
A
Y
V
S
R
E
T
L
Q
G
L
Y
Y
L
H
S
K
G
K
M
H
R
D
I
K
G
A
N
I
L
---
L
---
T
D
--
N
---
G
----
H
-
V
K
L
A
D
F
G
V
S
A
Q
I
T
A
-
T
-
I
A
---
A
F
I
-
G
T
P
Y
W
M
A
P
E
V
A
A
V
E
---
R
K
G
G
Y
N
Q
L
-
C
D
L
W
A
V
G
I
T
A
I
E
L
A
E
L
Q
P
P
M
F
D
L
H
P
M
---
R
--
A
L
F
L
M
T
K
S
-------------
N
F
Q
P
-
P
K
L
K
-
D
K
M
K
W
S
-
N
S
F
H
H
F
V
K
M
A
L
T
KN
P
K
K
R
P
T
A
E
K
L
L
Q
H
P
F
V
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
HHSearch
55.24
25%
-26
- C1 -
-
4NIF
-
KS6A1_HUMAN
A:
[7-272]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
G
Y
V
V
K
-
E
T
I
G
V
G
S
Y
S
E
C
K
R
C
V
H
K
A
T
N
M
E
Y
A
V
K
V
I
D
K
S
K
R
----------------------------
D
P
S
E
E
I
E
I
L
L
R
Y
G
-
Q
H
-
P
N
I
I
T
L
K
D
V
Y
D
D
--
G
K
H
V
Y
L
V
T
E
L
M
R
G
G
E
L
L
D
K
I
L
R
Q
------------
K
F
F
S
E
R
E
A
S
F
V
L
H
T
I
G
K
T
V
E
Y
L
H
S
Q
G
V
V
H
R
D
L
K
P
S
N
I
L
---
Y
---
V
D
--
E
---
S
GNPE
C
-
L
R
I
C
D
F
G
F
A
K
Q
L
R
A
-
E
-
N
G
L
L
M
T
P
C
-
Y
---
F
V
A
P
E
V
L
K
R
-----
Q
-
G
Y
D
E
G
-
C
D
I
W
S
L
G
I
L
L
Y
T
M
L
A
G
Y
T
P
F
A
N
G
P
S
D
---
T
P
E
E
I
L
T
R
I
--------------
G
S
G
K
F
-
T
L
S
G
G
N
W
N
T
V
S
-
E
T
A
K
D
L
V
S
K
M
L
H
VD
P
H
Q
R
L
T
A
K
Q
V
L
Q
H
P
W
V
T
Q
K
D
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
53.59
24%
-28
- C1 -
-
2Y7J
1
PHKG2_HUMAN
D:
[95-364]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
D
P
K
-
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
V
---
R
L
S
--------
P
E
Q
L
E
E
V
R
E
--------
A
T
R
R
E
T
H
I
L
R
Q
-
V
A
G
H
-
P
H
I
I
T
L
I
D
S
Y
E
S
--
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
------------
V
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
---
D
D
--
N
---
M
----
Q
-
I
R
L
S
D
F
G
F
S
C
H
L
-
E
-
P
-
G
E
K
L
R
E
L
C
-
G
T
P
G
Y
L
A
P
E
I
L
K
C
S
MDE
T
H
P
G
Y
G
K
E
-
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
R
R
Q
I
---
L
--
M
L
R
M
---------------
I
M
E
G
Q
Y
-
Q
F
S
S
P
E
W
D
D
R
S
-
S
T
V
K
D
L
I
S
R
L
L
Q
VD
P
E
A
R
L
T
A
E
Q
A
L
Q
H
P
F
F
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
51.99
31%
-90
- C1 -
-
3LM5
1
ST17B_HUMAN
A:
[21-205]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
S
M
E
N
F
N
N
F
Y
I
L
T
S
K
E
L
G
R
G
K
F
A
V
V
R
Q
C
I
S
K
S
T
G
Q
E
Y
A
A
K
F
-----
L
K
K
R
--------
R
R
G
Q
D
C
-
R
A
--------
E
I
L
H
E
I
A
V
L
E
L
-
A
-
K
S
C
P
R
V
I
N
L
H
E
V
Y
E
N
T
S
E
--
I
I
L
I
L
E
Y
A
A
G
G
E
I
F
S
L
-----
C
L
P
E
-----
L
-
E
M
V
S
E
N
D
V
I
R
L
I
K
Q
I
L
E
G
V
Y
Y
L
H
Q
N
N
I
V
H
L
D
L
K
P
Q
N
I
L
---
L
---
S
S
--
I
YP
L
G
----
D
-
I
K
I
V
D
F
G
M
S
R
K
I
------------
M
-
G
T
P
E
Y
L
A
P
E
I
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
51.92
31%
-88
- C1 -
-
3LM0
2
ST17B_HUMAN
A:
[21-205]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
S
M
E
N
F
N
N
F
Y
I
L
T
S
K
E
L
G
R
G
K
F
A
V
V
R
Q
C
I
S
K
S
T
G
Q
E
Y
A
A
K
F
-----
L
K
K
R
--------
R
R
G
Q
D
C
-
R
A
--------
E
I
L
H
E
I
A
V
L
E
L
-
A
-
K
S
C
P
R
V
I
N
L
H
E
V
Y
E
N
T
S
E
--
I
I
L
I
L
E
Y
A
A
G
G
E
I
F
S
L
-----
C
L
P
E
-----
L
A
E
M
V
S
E
N
D
V
I
R
L
I
K
Q
I
L
E
G
V
Y
Y
L
H
Q
N
N
I
V
H
L
D
L
K
P
Q
N
I
L
---
L
---
S
S
--
I
YP
L
G
----
D
-
I
K
I
V
D
F
G
M
S
R
K
I
------------
M
-
G
T
P
E
Y
L
A
P
E
I
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
51.67
22%
-74
- C1 -
-
2X4F
4
MYLK4_HUMAN
A:
[91-347]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
K
T
-
E
I
L
G
-----
Q
V
H
K
C
E
E
T
A
T
G
L
K
L
A
A
K
I
I
K
T
R
G
M
K
----------------
D
K
E
--------
E
V
K
N
E
I
S
V
M
N
Q
-
L
-
D
H
-
A
N
L
I
Q
L
Y
D
A
F
E
S
--
K
N
D
I
V
L
V
M
E
Y
V
D
G
G
E
L
F
D
R
I
I
D
E
-----------
S
Y
N
L
T
E
L
D
T
I
L
F
M
K
Q
I
C
E
G
I
R
H
M
H
Q
M
Y
I
L
H
L
D
L
K
P
E
N
I
L
---
C
VN-
R
D
--
A
---
K
----
Q
-
I
K
I
I
D
F
G
L
A
R
R
Y
-
K
-
P
-
R
E
K
L
K
V
N
F
-
G
T
P
E
F
L
A
P
E
V
V
N
Y
------
D
F
V
S
F
P
-
T
D
M
W
S
V
G
V
I
A
Y
M
L
L
S
G
L
S
P
F
L
G
D
N
D
A
E
T
L
N
--
N
I
L
A
C
R
W
-----------------
D
-
L
-
E
D
E
E
F
Q
D
I
S
-
E
E
A
K
E
F
I
S
K
L
L
I
KE
K
S
W
R
I
S
A
S
E
A
L
K
H
P
W
L
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
Fugue
51.17
17%
-25
- C1 -
-
1KOB
1
?
A:
[23-374]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
N
D
Y
D
K
F
Y
E
D
I
W
K
K
Y
V
P
Q
P
V
E
V
K
Q
G
S
V
Y
D
Y
Y
D
I
L
E
E
L
G
S
G
A
F
G
V
V
H
R
C
V
E
K
A
T
G
R
V
F
V
A
K
F
I
N
T
----------------
P
Y
P
L
D
K
Y
--------
T
V
K
N
E
I
S
I
M
N
Q
-
L
-
H
H
-
P
K
L
I
N
L
H
D
A
F
E
D
K
Y
--
E
M
V
L
I
L
E
F
L
S
G
G
E
L
F
D
R
-----
I
A
A
E
D
Y
K
------
M
S
E
A
E
V
I
N
Y
M
R
Q
A
C
E
G
L
K
H
M
H
E
H
S
I
V
H
L
D
I
K
P
E
N
I
M
CE-
T
---
K
K
--
A
---
S
----
S
-
V
K
I
I
D
F
G
L
A
T
K
L
-
N
-
P
-
D
E
I
V
K
V
T
T
-
A
T
A
E
F
A
A
P
E
I
V
----------------
D
R
E
P
V
G
F
Y
T
D
M
W
A
I
G
V
L
G
Y
V
L
L
S
G
L
---
S
--
P
F
A
G
E
D
D
L
E
T
L
Q
N
V
K
R
C
D
W
E
F
D
E
D
A
F
S
S
V
S
P
E
A
K
D
F
I
K
N
L
L
Q
K
------
E
--
P
R
K
R
L
T
V
H
D
A
L
E
H
P
W
L
K
G
D
H
S
N
L
T
S
R
I
P
S
S
R
Y
N
K
I
R
Q
K
I
K
E
K
Y
A
D
W
P
A
P
Q
P
A
I
G
R
I
A
N
F
S
S
L
R
K
H
R
P
Q
E
Y
Q
I
Y
D
S
Y
F
D
R
K
E
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
50.77
20%
-48
- C1 -
-
1TKI
-
TITIN_HUMAN
A:
[22-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
Y
M
I
A
-
E
D
L
G
R
G
E
F
G
I
V
H
R
C
V
E
T
S
S
K
K
T
Y
M
A
K
F
V
K
V
K
G
T
-----------------
D
Q
V
--------
L
V
K
K
E
I
S
I
L
N
I
-
A
-
R
H
-
R
N
I
L
H
L
H
E
S
F
E
S
--
M
E
E
L
V
M
I
F
E
F
I
S
G
L
D
I
F
E
R
I
N
T
S
A
-----------
F
E
L
N
E
R
E
I
V
S
Y
V
H
Q
V
C
E
A
L
Q
F
L
H
S
H
N
I
G
H
F
D
I
R
P
E
N
I
I
---
Y
---
Q
T
RR
S
---
S
----
T
-
I
K
I
I
E
F
G
Q
A
R
Q
L
-
K
-
P
-
G
D
N
F
R
L
L
F
-
T
A
P
E
Y
Y
A
P
E
V
H
Q
H
------
D
V
V
S
T
A
-
T
D
M
W
S
L
G
T
L
V
Y
V
L
L
S
G
I
N
P
F
L
A
E
T
N
Q
---
Q
--
I
I
E
N
I
M
---------------
N
A
E
Y
-
T
F
D
E
E
A
F
K
E
I
S
I
-
E
A
M
D
F
V
D
R
L
L
V
KE
R
K
S
R
M
T
A
S
E
A
L
Q
H
P
W
L
K
Q
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
49.88
29%
-97
- C1 -
-
3KK8
-
KCC2D_CAEEL
A:
[13-179]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
G
K
G
A
F
S
V
V
R
R
C
V
H
K
T
T
G
L
E
F
A
A
K
I
I
N
T
K
K
L
S
A
R
--------
D
F
Q
--------------
K
L
E
R
E
A
R
I
C
R
K
-
L
-
Q
H
-
P
N
I
V
R
L
H
D
S
I
Q
E
E
S
--
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
------------
E
D
I
V
A
R
E
F
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
I
A
Y
C
H
S
N
G
I
V
H
R
N
L
K
P
E
N
L
L
LAS
K
---
A
K
--
G
---
A
----
A
-
V
K
L
A
D
F
G
L
A
I
E
V
-
N
-
D
-
S
E
A
W
H
G
F
A
-
G
T
P
G
Y
L
S
P
E
V
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
47.73
34%
-27
- C1 -
-
5UYJ
1
KKCC2_HUMAN
A:
[6-201]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
T
L
K
D
-
E
I
G
K
G
S
Y
G
V
V
K
L
A
Y
N
E
N
D
N
T
Y
Y
A
M
K
V
L
S
K
K
K
L
I
R
Q
A
GFPRRPP--------
C
IQPRGPI
E
Q
V
Y
Q
E
I
A
I
L
K
K
-
L
-
D
H
-
P
N
V
V
K
L
V
E
V
L
D
D
P
N
E
D
H
L
Y
M
V
F
E
L
V
N
Q
G
P
V
M
E
V
P
T
---
L
K
P
L
S
E
D
Q
----------
A
R
F
Y
F
Q
D
L
I
K
G
I
E
Y
L
H
Y
Q
K
I
I
H
R
D
I
K
P
S
N
L
L
---
V
---
G
E
--
D
---
G
----
H
-
I
K
I
A
D
F
G
V
S
N
E
F
-
K
-
G
-
S
D
A
L
L
S
N
T
V
G
T
P
A
F
M
A
P
E
S
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------