@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_19_1640: (2018-03-09 )
MSARRSRLRRVRWLPHQRIVVLKEVDLWAEDCVTEGVDVVAERLWRMRMDASRNGRAQYLAEYLALHVDSSRHYQWLLSNYGPSLRDVLLTSSLTPFTEERCKGVLRRVLLALDQLHRVSMYVHADVSLGNVLTSPSSCDDVVLGDLESVSPIGAVPRGCLGSYLFMAPERLVDGALPLAPHDDIWAFGIVCYNLLTWDVTHPWCALGTESDHSENYWAFLDLMSKAKDVPPCQLLLQSPLSRCSKEALTFVAVCLSWDPACRPSAAELLQHSWMLSP
Atome Classification :
(20 SA)
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........10........20....-------....30.----.--......40...-----.....50.-.......60........70........80--........90........100.......110.......120.......130.....--.--.--140.......150.--.--...---..160........170...----....180.......190.......200.......210.......220...-----.----------------------------------...230...--....240.......250.......260.-----......270......----------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------MS
A
R
R
S
R
L
R
R
V
RWLPH
Q
R
I
V
V
L
K
EV-------
D
L
W
A
E
D
C
----
V
--TE
G
V
D
V
V
A
E
R
L
-----
W
R
M
RMDAS-RN
G
R
A
Q
Y
L
A
E
Y
L
A
L
HVDSSR
H
Y
Q
W
L
L
S
NY--GP
S
L
R
D
V
L
L
TSSLTP
F
T
E
E
R
C
K
G
V
L
R
R
V
L
L
A
L
D
Q
L
H
R
V
S
M
Y
V
H
A
D
V
SLGNVLTSPS--S--C--D
D
V
VLGDLESVSPI--G--AV
P
---
R
G
C
L
-
G
S
Y
L
F
M
A
P
E
R
LVDG----ALPLAPHD
D
I
W
A
F
G
I
V
C
Y
N
L
LTWDVTH
P
W
CALGTESDHSE
N
Y
W
A
F
L
D
L
M
S
-----K----------------------------------AKDV
P
P
C
Q
L
--
L
L
Q
S
P
L
S
R
C
S
K
E
A
L
T
F
V
A
V
C
LSWDPACR-----
P
S
A
A
E
L
L
Q
H
SWMLSP----------------------------------------------------------------
41
HHSearch
78.69
25%
-68
- C1 -
-
5J5T
1
M4K3_HUMAN
A:
[13-267]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
G
T
Y
G
D
V
Y
K
A
R
N
V
N
T
G
E
L
A
A
I
K
V
I
-------
K
L
E
P
G
E
-----
D
--
F
---
A
V
V
Q
Q
E
I
-----
I
M
M
K
D
C
---
K
---
H
P
N
I
V
A
Y
F
G
S
Y
L
R
R
D
K
L
W
-
I
C
M
E
F
C
G-
G
G
S
L
Q
D
I
Y
H
V
T
--
G
P
L
S
E
L
Q
I
A
Y
V
S
R
E
T
L
Q
G
L
Y
Y
L
H
S
K
-
G
K
M
H
R
D
I
K
G
A
N
I
L
L
T
D
N
--
G
--
H
----
V
K
L
A
D
F
G
V
S
A
Q
I
--
T
--
A
T
I
A---
A
F
I
-
G
T
P
Y
W
M
A
P
E
V
A
A
V
E
R---
K
G
G
Y
N
Q
L
C
D
L
W
A
V
G
I
T
A
I
E
L
A
E
L
Q
--
P
P
M
F
D
L
H
P
--------
M
R
A
L
F
L
M
T
-----
K
----------------------------------
S
N
F
Q
P
P
-
K
L
-----
K
D
K
M
K
W
S
N
S
F
H
H
F
V
K
M
A
L
T
K
N
P
K
K
R
-----
P
T
A
E
K
L
L
Q
H
P
F
V
T
Q
-----------------------------------------------------------------
26
HHSearch
76.37
19%
-63
- C1 -
-
1KOB
1
?
A:
[60-310]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
G
A
F
G
V
V
H
R
C
V
E
K
A
T
G
R
V
F
V
A
K
F
I
-------
N
T
P
Y
P
L
-----
D
--
K
---
Y
T
V
K
N
E
I
-----
S
I
M
N
Q
L
---
H
---
H
P
K
L
I
N
L
H
D
A
F
E
D
K
Y
E
M
V
-
L
I
L
E
F
L
S
-
G
G
E
L
F
D
R
I
A
A
E
D
-
Y
K
M
S
E
A
E
V
I
N
Y
M
R
Q
A
C
E
G
L
K
H
M
H
E
H
-
S
I
V
H
L
D
I
K
P
E
N
I
M
C
E
T
K
--
K
--
A
--
S
S
V
K
I
I
D
F
G
L
A
T
K
L
--
N
--
P
D
E
I
V
-
K
V
T
T
-
A
T
A
E
F
A
A
P
E
I
V
D
------
R
E
P
V
G
F
Y
T
D
M
W
A
I
G
V
L
G
Y
V
L
L
S
G
L
--
S
P
F
A
G
E
D
D
--------
L
E
T
L
Q
N
-------
V
----------------------------------
K
R
C
D
W
E
-
F
D
----
E
D
A
F
S
S
V
S
P
E
A
K
D
F
I
K
N
L
L
Q
K
E
P
R
K
R
-----
L
T
V
H
D
A
L
E
H
P
W
L
K
G
-----------------------------------------------------------------
45
HHSearch
74.38
21%
-58
- C1 -
-
2QR8
-
A:
[31-283]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
V
G
S
Y
S
V
C
K
R
C
I
H
K
A
T
N
M
E
F
A
V
K
I
I
-------
D
K
S
K
--------------
R
D
P
T
E
E
I
-----
E
I
L
L
R
Y
---
G
Q
--
H
P
N
I
I
T
L
K
D
V
Y
D
D
G
K
Y
V
Y
-
V
V
T
E
L
M
K-
G
G
E
L
L
D
K
I
L
R
Q
--
K
F
F
S
E
R
E
A
S
A
V
L
F
T
I
T
K
T
V
E
Y
L
H
A
Q
-
G
V
V
H
R
D
L
K
P
S
N
I
L
Y
V
D
E
SG
N
--
P
--
E
S
I
R
I
C
D
F
G
F
A
K
Q
L
--
R
--
A
E
N
G
L
L
M
T
P
C
-
Y
T
A
N
F
V
A
P
E
V
L
E
------
R
Q
G
Y
D
A
A
C
D
I
W
S
L
G
V
L
L
Y
T
M
L
T
G
Y
--
T
P
F
A
N
G
P
D
-----
D
T
P
E
E
I
L
A
R
-------
I
----------------------------------
G
S
G
K
F
S
--
L
--
S
-
G
G
Y
W
N
S
V
S
D
T
A
K
D
L
V
S
K
M
L
H
V
D
P
H
Q
R
-----
L
T
A
A
L
V
L
R
H
P
W
I
V
H
-----------------------------------------------------------------
27
HHSearch
72.06
23%
-61
- C1 -
-
4XBR
1
INKA1_HUMAN (first)
A:
[103-349]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
-------
D
L
R
K
Q
Q
-----
R
--
R
---
E
L
L
F
N
E
V
-----
V
I
M
R
D
Y
---
Q
---
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
-
V
V
M
E
F
L
E-
G
G
A
L
T
D
I
V
T
H
T
---
R
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
-
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
--
G
--
R
----
V
K
L
S
D
F
G
F
C
A
Q
V
--
S
--
K
E
V
PRR
K
S
L
V
-
G
T
P
Y
W
M
A
P
E
L
I
S
------
R
L
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
--
P
P
Y
F
N
E
P
P
-----
L
---
K
A
M
K
M
-------
I
----------------------------------
R
D
N
L
P
P
-
R
L
----
K
-
N
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
-----
A
T
A
A
E
L
L
K
H
P
F
L
A
K
-----------------------------------------------------------------
30
HHSearch
72.00
20%
-41
- C1 -
-
2Y7J
1
PHKG2_HUMAN
C:
[103-364]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
-------
E
V
T
A
E
R
L
SPEQ
L
--
E
E
V
R
E
A
T
R
R
E
T
-----
H
I
L
R
Q
V
---
A
G
--
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
F
-
L
V
F
D
L
M
R-
K
G
E
L
F
D
Y
L
T
E
K
--
V
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
-
N
I
V
H
R
D
L
K
P
E
N
I
L
L
D
D
N
--
M
--
Q
----
I
R
L
S
D
F
G
F
S
C
H
L
--
E
--
P
G
E
KL-
R
E
L
C
-
G
T
P
G
Y
L
A
P
E
I
L
K
C
S
MDET
H
P
G
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
--
P
P
F
W
H
R
R
Q
--------
I
L
M
L
R
M
-------
I
----------------------------------
M
E
G
Q
Y
Q
F
S
-----
S
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
-----
L
T
A
E
Q
A
L
Q
H
P
F
F
E
------------------------------------------------------------------
31
HHSearch
71.81
19%
-71
* C1 *
-
5IG1
-
?
A:
[26-278]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
G
A
F
S
T
V
H
R
C
V
N
K
R
T
G
E
V
C
A
V
K
V
I
-------
A
L
K
S
L
R
--------
S
S
E
I
N
K
I
K
R
E
I
-----
G
I
C
S
S
L
---
Q
---
H
E
H
I
V
S
M
R
R
A
F
R
D
E
S
H
F
Y
-
L
V
F
E
Y
V
S-
G
G
E
L
F
D
E
I
V
T
R
--
K
F
Y
N
E
K
D
A
S
A
C
M
H
Q
I
L
S
A
L
Q
H
C
H
S
K
-
N
I
I
H
R
D
L
K
P
E
N
L
L
L
A
S
K
D-
P
--
N
--
A
P
V
K
I
T
D
F
G
L
A
V
I
M
--
E
--
Q
G
P
TY-
F
G
F
A
-
G
T
P
G
Y
L
S
P
E
V
I
R
------
R
V
P
Y
D
T
A
V
D
V
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
--
P
P
F
W
E
E
D
H
--------
Q
K
L
Y
A
Q
I
K
-----
N
----------------------------------
C
Q
Y
D
F
P
-------
S
P
E
W
D
S
V
T
T
A
A
K
E
L
I
K
A
M
L
E
P
N
P
K
R
R
-----
P
T
V
Q
E
L
L
Q
H
P
W
I
A
R
-----------------------------------------------------------------
32
HHSearch
71.29
19%
-71
- C1 -
-
5IG1
-
?
B:
[26-278]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
G
A
F
S
T
V
H
R
C
V
N
K
R
T
G
E
V
C
A
V
K
V
I
-------
A
L
K
S
L
R
--------
S
S
E
I
N
K
I
K
R
E
I
-----
G
I
C
S
S
L
---
Q
---
H
E
H
I
V
S
M
R
R
A
F
R
D
E
S
H
F
Y
-
L
V
F
E
Y
V
S-
G
G
E
L
F
D
E
I
V
T
R
--
K
F
Y
N
E
K
D
A
S
A
C
M
H
Q
I
L
S
A
L
Q
H
C
H
S
K
-
N
I
I
H
R
D
L
K
P
E
N
L
L
L
A
S
K
D-
P
--
N
--
A
P
V
K
I
T
D
F
G
L
A
V
I
M
--
E
--
Q
G
P
TY-
F
G
F
A
-
G
T
P
G
Y
L
S
P
E
V
I
R
------
R
V
P
Y
D
T
A
V
D
V
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
--
P
P
F
W
E
E
D
H
--------
Q
K
L
Y
A
Q
I
K
-----
N
----------------------------------
C
Q
Y
D
F
P
-------
S
P
E
W
D
S
V
T
T
A
A
K
E
L
I
K
A
M
L
E
P
N
P
K
R
R
-----
P
T
V
Q
E
L
L
Q
H
P
W
I
A
R
-----------------------------------------------------------------
34
HHSearch
69.85
17%
-63
- C1 -
-
4AZF
2
DYRK2_HUMAN
A:
[106-413]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
G
S
F
G
Q
V
V
K
A
Y
D
H
K
V
H
Q
H
V
A
L
K
M
V
-------
R
N
E
K
R
------
F
--
H
---
R
Q
A
A
E
E
I
-----
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
N
V
I
H
M
L
E
N
F
T
F
R
N
H
I
C
-
M
T
F
E
L
L
--
S
M
N
L
Y
E
L
I
K
K
N
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
H
K
N
-
R
I
I
H
C
D
L
K
P
E
N
I
L
L
K
Q
Q
--
G
--
R
--
S
G
I
K
V
I
D
F
G
S
S
C
Y
E
--
H
--
Q
R
V
---
Y
T
Y
I
-
Q
S
R
F
Y
R
A
P
E
V
I
L
------
G
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
--
P
L
L
P
G
E
D
E
G
D
Q
-
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
D
A
SKRAKNFVSSKGYP
R
Y
C
T
V
T
TLS
D
V
V
L
N
G
G
RSR
R
G
K
L
R
G
P
P
E
S
R
E
W
G
N
A
L
K
G
C
D
D
P
L
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
-----
M
T
P
G
Q
A
L
R
H
P
W
L
R
------------------------------------------------------------------
35
HHSearch
66.50
19%
-26
- C1 -
-
2X0G
-
DAPK1_HUMAN
A:
[20-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
-------
K
K
R
R
T
K
S
SR--
R
--
G
V
S
R
E
D
I
E
R
E
V
-----
S
I
L
K
E
I
---
Q
---
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
-
L
I
L
E
L
V
A-
G
G
E
L
F
D
F
L
A
E
K
--
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
-
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
--
N
VP
K
--
P
R
I
K
I
I
D
F
G
L
A
H
K
I
--
D
--
F
G
N
EF-
K
N
I
F
-
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
--
S
P
F
L
G
D
T
K
-----
Q
E
T
L
A
N
V
S
--------
A
----------------------------------
V
N
Y
E
F
E
-------
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
-----
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
-----------------------------------------------------------------
33
HHSearch
65.88
21%
-50
- C1 -
-
4NIF
-
KS6A1_HUMAN
A:
[17-269]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
V
G
S
Y
S
E
C
K
R
C
V
H
K
A
T
N
M
E
Y
A
V
K
V
I
-------
D
K
S
K
--------------
R
D
P
S
E
E
I
-----
E
I
L
L
R
Y
---
G
Q
--
H
P
N
I
I
T
L
K
D
V
Y
D
D
G
K
H
V
Y
-
L
V
T
E
L
M
R-
G
G
E
L
L
D
K
I
L
R
Q
--
K
F
F
S
E
R
E
A
S
F
V
L
H
T
I
G
K
T
V
E
Y
L
H
S
Q
-
G
V
V
H
R
D
L
K
P
S
N
I
L
Y
V
D
E
--
S
--
G
NP
E
C
L
R
I
C
D
F
G
F
A
K
Q
L
--
R
--
A
E
N
GLL
M
T
P
C
-
Y
---
F
V
A
P
E
V
L
K
------
R
Q
G
Y
D
E
G
C
D
I
W
S
L
G
I
L
L
Y
T
M
L
A
G
Y
--
T
P
F
A
N
G
P
S
-----
D
T
P
E
E
I
L
T
R
-------
I
----------------------------------
G
S
G
K
F
T
--
L
--
S
-
G
G
N
W
N
T
V
S
E
T
A
K
D
L
V
S
K
M
L
H
V
D
P
H
Q
R
-----
L
T
A
K
Q
V
L
Q
H
P
W
V
T
Q
-----------------------------------------------------------------
44
HHSearch
65.15
19%
-27
- C1 -
-
4B4L
3
DAPK1_HUMAN
A:
[22-279]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
-------
K
K
R
R
T
K
S
----
S
RR
G
V
S
R
E
D
I
E
R
E
V
-----
S
I
L
K
E
I
---
Q
---
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
-
L
I
L
E
L
V
A-
G
G
E
L
F
D
F
L
A
E
K
--
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
-
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
--
N
VP
K
--
P
R
I
K
I
I
D
F
G
L
A
H
K
I
--
D
--
F
G
N
E
F
-
K
N
I
F
-
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
--
S
P
F
L
G
D
T
K
-----
Q
E
T
L
A
N
V
S
--------
A
----------------------------------
V
N
Y
E
F
E
-------
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
-----
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
-----------------------------------------------------------------
50
Fugue
63.68
17%
19
- C1 -
-
2ACX
1
GRK6_HUMAN
A:
[14-532]
KARKGKSKK
W
R
Q
M
L
QFPHISQC
E
E
L
R
L
S
LERD
Y
H
S
L
C
ERN
P
I
G
R
L
L
F
R
E
F
C
A
T
R
P
E
L
S
R
C
V
A
F
L
D
G
V
A
E
Y
E
V
TPDDK
R
K
A
C
G
R
N
L
T
Q
N
FLSHTGPDLIPEVP
R
Q
L
V
T
N
C
T
Q
R
L
E
Q
GPCKDLF
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
QPVTKNT
F
R
Q
Y
R
VL
G
K
G
G
F
G
E
V
C
A
C
Q
V
R
A
T
G
K
M
Y
A
C
K
K
L
-------
E
--
K
K
R
I
----
K
--
K
R
K
----
G
E
A
M
-----
A
L
N
E
K
Q
I
L
-
E
K
V
N
S
R
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
--
G
G
D
L
K
F
H
I
Y
H
M
G
Q
A
G
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
-
E
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
H
--
G
------
H
I
R
I
S
D
L
G
L
A
V
H
V
P
E
G
--
Q
T
I
---
K
G
R
V
-
G
T
V
G
Y
M
A
P
E
V
V
K
N
E
----
R
Y
T
--
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
--
S
P
F
---
Q
Q
R
K
K
K
I
K
R
E
E
V
E
R
L
V
K
E
-----
V
----------------------------------
P
E
E
Y
S
E
------------
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
LGCRG
G
S
A
R
E
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
GMLEPPFKPDPQAIYCE
P
T
D
Q
D
F
Y
Q
K
F
ATGSVP
I
P
W
Q
N
E
M
V
E
T
E
C
F
Q
E
L
N
VFGLDGS
37
HHSearch
61.06
19%
-100
- C1 -
-
5K00
1
MELK_HUMAN
A:
[17-264]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
G
--
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
-------
D
K
N
T
L
G
S
----
D
-----
L
P
R
I
K
T
E
I
-----
E
A
L
K
N
L
---
R
---
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
-
M
V
L
E
Y
C
P-
G
G
E
L
F
D
Y
I
I
S
Q
--
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
-
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
--
H
--
K
----
L
K
L
I
D
F
G
L
C
A
K
P
-----------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
-----
S
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
--
L
P
F
D
D
D
N
--------
V
M
A
L
Y
K
K
-------
I
----------------------------------
M
R
G
K
Y
D
--
V
-------
P
K
W
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
-----
I
S
M
K
N
L
L
N
H
P
W
I
M
Q
-----------------------------------------------------------------
38
HHSearch
59.65
20%
-38
- C1 -
-
2Y7J
1
PHKG2_HUMAN
D:
[103-364]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
-------
E
V
---
R
L
SPEQ
L
--
E
E
V
R
E
A
T
R
R
E
T
-----
H
I
L
R
Q
V
---
A
G
--
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
F
-
L
V
F
D
L
M
R-
K
G
E
L
F
D
Y
L
T
E
K
--
V
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
-
N
I
V
H
R
D
L
K
P
E
N
I
L
L
D
D
N
--
M
--
Q
----
I
R
L
S
D
F
G
F
S
C
H
L
--
E
--
P
G
E
KL-
R
E
L
C
-
G
T
P
G
Y
L
A
P
E
I
L
K
C
S
MDET
H
P
G
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
--
P
P
F
W
H
R
R
Q
--------
I
L
M
L
R
M
-------
I
----------------------------------
M
E
G
Q
Y
Q
F
S
-----
S
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
-----
L
T
A
E
Q
A
L
Q
H
P
F
F
E
------------------------------------------------------------------
49
Fugue
56.14
17%
-24
- C1 -
-
4DN5
7
M3K14_HUMAN
A:
[8-351]
---------------------------------------------------------------------------------------------------------------------------S
V
E
E
Y
L
V
H
A
L
QG
S
V
S
S
G
Q
A
H
S
L
T
S
L
A
K
T
W
A
A
R
G
S
RSREPSPKTE
D
N
E
G
V
L
L
T
E
K
L
K
P
V
D
Y
E
Y
R
E
E
V
H
W
A
T
H
Q
L
R
LGRGSF
G
E
V
H
R
M
E
D
----
K
--
Q
T
G
F
Q
C
A
V
K
K
V
R
LEVF
R
A
E
E
L
M
A
C
-
A
G
L
T
S
P
R
I
V
P
L
Y
G
A
V
R
E
G
P
W
V
N
I
F
M
E
L
L
E
--
G
G
S
L
G
Q
L
V
K
E
Q
G
--
C
L
P
E
D
R
A
L
Y
Y
L
G
Q
A
L
E
G
L
E
Y
L
H
S
R
R
-
I
L
H
G
D
V
K
A
D
N
V
L
L
S
S
D
--
G
--
S
--
H
-
A
A
L
C
D
F
G
H
A
V
C
L
--
Q
--
I
P
---------
G
T
E
T
H
M
A
P
E
V
V
L
G
R
----
S
C
D
--
A
K
V
D
V
W
S
S
C
C
M
M
L
H
M
L
N
G
C
--
H
P
W
----
T
Q
F
F
R
G
P
L
C
L
K
I
A
S
E
P
P
-----
P
----------------------------------
V
R
E
I
P
P
------------
S
C
A
P
L
T
A
Q
A
I
Q
E
G
L
R
K
E
P
I
H
R
-----
V
S
A
A
E
L
G
G
K
V
N
R
A
L
Q
Q
V
GGLKSPWR
G
E
Y
K
E
P
RHP---------------------------------------------
11
PsiBlast_PDB
53.86
29%
3
- C1 -
-
3A7G
-
STK24_HUMAN
A:
[81-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
--
L
W
I
I
M
E
Y
LG
G
G
S
A
L
D
L
L
E
P
G
---
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
-
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
--
G
------
E
V
K
L
A
D
F
G
V
A
G
Q
L
--
T
DT
Q
I
K
---
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
Q
S
----
A
Y
--
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
----------
A
R
G
-
E
P
P
H
S
E
L
H
P
M
K
V
-
L
F
L
-----
I
----------------------------------
P
K
N
N
P
P
T
-----
L
E
G
N
Y
S
K
P
L
K
E
---
F
V
E
A
C
L
N
K
E
P
S
F
R
-----
P
T
A
K
E
L
L
K
H
K
F
I
L
------------------------------------------------------------------
14
PsiBlast_PDB
53.75
29%
4
- C1 -
-
3A7J
1
STK24_HUMAN
A:
[81-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
--
L
W
I
I
M
E
Y
LG
G
G
S
A
L
D
L
L
E
P
G
---
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
-
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
--
G
------
E
V
K
L
A
D
F
G
V
A
G
Q
L
--
T
DT
Q
I
K
---
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
Q
S
----
A
Y
--
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
----------
A
R
G
-
E
P
P
H
S
E
L
H
P
M
K
V
-
L
F
L
-----
I
----------------------------------
P
K
N
N
P
P
T
-----
L
E
G
N
Y
S
K
P
L
K
E
---
F
V
E
A
C
L
N
K
E
P
S
F
R
-----
P
T
A
K
E
L
L
K
H
K
F
I
L
------------------------------------------------------------------
13
PsiBlast_PDB
53.75
29%
5
- C1 -
-
3A7I
1
STK24_HUMAN
A:
[81-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
--
L
W
I
I
M
E
Y
LG
G
G
S
A
L
D
L
L
E
P
G
---
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
-
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
--
G
------
E
V
K
L
A
D
F
G
V
A
G
Q
L
--
T
DT
Q
I
K
---
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
Q
S
----
A
Y
--
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
----------
A
R
G
-
E
P
P
H
S
E
L
H
P
M
K
V
-
L
F
L
-----
I
----------------------------------
P
K
N
N
P
P
T
-----
L
E
G
N
Y
S
K
P
L
K
E
---
F
V
E
A
C
L
N
K
E
P
S
F
R
-----
P
T
A
K
E
L
L
K
H
K
F
I
L
------------------------------------------------------------------
43
HHSearch
53.11
18%
-60
- C1 -
-
2BDW
-
KCC2D_CAEEL
A:
[20-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
G
A
F
S
V
V
R
R
C
V
H
K
T
T
G
L
E
F
A
A
K
I
I
-------
N
T
K
K
L
S
--------
A
R
D
F
Q
K
L
E
R
E
A
-----
R
I
C
R
K
L
---
Q
---
H
P
N
I
V
R
L
H
D
S
I
Q
E
E
S
F
H
Y
-
L
V
F
D
L
V
T-
G
G
E
L
F
E
D
I
V
A
R
--
E
F
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
I
A
Y
C
H
S
N
-
G
I
V
H
R
N
L
K
P
E
N
L
L
L
A
S
K
--
A
K-
G
--
A
A
V
K
L
A
D
F
G
L
A
I
E
V
--
N
--
D
S
E
A
W
-
H
G
F
A
-
G
T
P
G
Y
L
S
P
E
V
L
K
------
K
D
P
Y
S
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
--
P
P
F
W
D
E
D
--------
Q
H
R
L
Y
A
Q
I
K
-----
A
----------------------------------
G
A
Y
D
Y
P
-------
S
P
E
W
D
T
V
T
P
E
A
K
S
L
I
D
S
M
L
T
V
N
P
K
K
R
-----
I
T
A
D
Q
A
L
K
V
P
W
I
C
N
-----------------------------------------------------------------
1
PsiBlast_PDB
52.58
29%
3
- C1 -
-
2XIK
2
STK25_HUMAN
A:
[78-271]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
I
T
R
Y
F
G
S
Y
L
K
S
T
K
--
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
K
P
G
---
P
L
E
E
T
Y
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
-
E
R
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
--
G
------
D
V
K
L
A
D
F
G
V
A
G
Q
L
--
T
DT
Q
I
K
---
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
Q
S
----
A
Y
D
F
K
A
--
D
I
W
S
L
G
I
T
A
I
E
L
----------
A
K
G
E
P
P
N
S
D
L
H
P
M
R
V
L
F
L
I
-----------------------------------------
P
K
N
S
P
P
T
-----
L
E
G
Q
H
S
K
P
F
K
E
---
F
V
E
A
C
L
N
K
D
P
R
F
R
-----
P
T
A
K
E
L
L
K
H
K
F
I
-------------------------------------------------------------------