@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
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Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
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Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_20_0780: (2018-03-09 )
MSDFSSSSSDSSSDDGIFTRRVEFQQRQRGASSSSSVPALGSSATRDVVAIISESAPPCTVDAVEAPATAGATTSRARSQPPDVAPVVLSERVTTQTSLQSASTGSEDKSSPGGSPVQRRRRRVAGTRPPAIKGALGSPTEPKQQRGRRSSVSDPGSPLELPPPSRSSSRQRRTSVHSMSTADLAAATLVRASSNTLSTSTNKRTGGRGGGGVRRRYPRGAATTSLRALSPVSVSPTASAVNARLLSDEAYLDMFHIPALIAQLSLSLMAAKPIDPRAFTRDWLADRLVSEEDEDDDNADDGGGSTNSGSGAREQGSQVPPSDTAVLTRSTELPSSTSFVFQASGSTMGDFASDSGAARPCLTEVSYRQGRSGQHSRQRRRTNTSGEDEADDVAKTPLEADSDGDKTGTVIDRPASVGHASRKRRAFERRAQRKDRQSVATPSESRQRGVCGISNGAESRRNEMSASSRNNTSDDAYSRSPRCGSLLTTLAPPPAEACEHREPRAAECEASSPMQRSEEAERNATAAAPSSLPPTPKTSSSSSPSSSSSSFTAFRSPGSDGVEWARVELQSRRTTVAGSSASADVDIPSSHRRMTMESESSTSTEGLSAPHGTTHGEHEVRQSSSSSRAAETAVNDVPALVTVERKGIHKSCSSSSSSSAGDGAHGLAALAHDRVGHTSGRAIELSTAASSMIRPEASVAKRGAAKEEFSRSDNEAEEGGEAERHSNYVAADIAEPAHSTTRGSEKDAADAAAAAAESHGRDGDDDFSFAMFVPILAVDATTNEVIDYREAGVSPPSAPAFSPTSGGACALPSYPTVSASGVGGGHLAQTHTSTAVTQSSGFPPYATRPVSSTFNVLPTPMLADLVGGGGLTNTSFGRRGVPNTSFGRRPAPMAGAAGRYVDPAAGAMTGSSSPPAPFITPHAPMDLPALGVSDGVVDGESLENLQLLGFPKLNSNLAAVSVGSVTGVRTSGSVVVAGEAASVRERKAVQDDDVADSNRAAPSAFCQSAVLHGATDGARNTNLSLTKDTLGPVVALSTASSPVSSTMKLESARRLGKLLDQLPAAKYAAAIVFLEGLLSSSGGSSDAAATPESESISMMTNIGDASNRNRGLLNLTSTAADTTLGSVGLSGDGSSPLVGSITPGRPWSGTFGPGRSPTGRARSFAHLVAGGSSQAPALAASGRNEDGAGALAMVSRAPEGGHSRSRSKGGSTSVEALVRDALSQSVLRSLPPTHEEVPGSVPSLPLRLEVSGRGAGEGTSMGMHRVPSPTRLENTHGERFASTATSTARANTSRGSSPVPVVPGGGSDDVTLQHPPSQSERSNLSFYKQPSSTDMSNLRRRSSSPSPGGYALTAAALQQQQQSQQQPVTRKATEDRLGSAVATMLPQSLSGPPPLSPAGNSSLATTGISVSEQKLMGVAVPTQPGASCVADHDEATTPEHSTARTATAADARGADSGNEDHQGAAFGGSDSCDLGSYAAQQRQNQALQHHHGIVSSSDQSLAAHATDQNTVDRFATTGAAAEAAEPSATVAPKALEGTQRRCSNGNGGSLLLLEQRGARGDGDESTLPPECGTHEQFMPLDAAANPISLHTHSAESVSSLSSGTAPITNSGADGGGGRRAGNAPGYWPGTFGNSQVSGSAAAEAPQERPQSGRELCSSAAKSSSASAGGSSGVVGWGGTVSDSPSPPLHAHHPHSAGRELEFEDVNLGATLRMAVALAAAAGTQSARTVYGSHSSSKDSMNGPAIKSSTPNQSAGVAVVSGANVVTADPFASADANEGLSSLATADETYVNDLFVTHSSQSPPTLHGNNHKPLLRMVDGSGAGEDCVSLPSSQTVSLLNTCSSSVAEGGDVSAATASILPPAIPPVAVSADGTVLATPITAAMTPIILEPSTQSPPRSELPMVTSSVVVAMNSFFSREDHVAPEELEVVREVVAHYDAFASLDETQLETLVRTMGRMELQRGATVVREGDSTLGQLLLIVSGKLTISRKGLVTRTLARGQFYGEMEMSYHVERSRVTLTAATPTVVLYALKKVDYQKLVIHEKDARRYMFLQYVNECVLFKGLSPYIKMRLADSFRVCRLRKGTKLTEQGASVEWMYLLMSGNVRMTYQAPPSTGGETSDWPLPWRGAAPEEEARHTVTTSHSFSNFAGSTTLSEAHMSSAASAAAASTAAGTSTTRCGTAPSGITGSLSSSLTPLTVASQLPSSALLLSQAAMASLNAGAQQQDMLAERAASSAEACKESPLISMVSPSPGANAATSRMPQLLHLPNAKAAHANSRGKSGDHLAEQGADDGPPRPNSSRPRSRRLQSQQDRSVSGWQGLSQPSASAAESLDTDNTKPPSPLSTSASVRQSANTLLDTTPHSNAASTVTTSLTNTAAALAGAAGVHKTVVVVDRSKGQLVGETEFVFKCKGLFTAVATTPVQAARISRLHFEAIMTRAVVEEMKRSMLLNPDYYFFEFTVPEALKEDMRRMLFRLNVGPAARRRTRHAQQHQRLRHSVTGVEGTVSGSRSRGGTAGGNRDSEAGRRHCRQSMVLSRRTQREHNRASFMDNITGGPGGSSNGPNGTTGSSGSNSHSTSPPLVAVCVQDGGRERNDGSTSQVGSKRHHAGHRRFRTAPLEISPTMARLSTERATADSVDAAGMESSALHYLAAPTVCGGPFASPAVASTAVVSSTSAGEDSVSFTPAPAATMGSMGNVKGRGSSSDGDHNRYSRATARLTTAGRRTSFTKHSSTTTSIRRRVSTRGEIVFSGSRNLYRFTAEAMSMNESIVIAVVVDGTIIRWNSVAQSVTGYAPFEAIGKSVFDFIVSEDGRQHMRDTLAVAARFAGRWEQYNMRGLQEQRVFPFRQNAGLYQVGLALSVIPSNYAKTAEVLLLIGREGKYRAASTYAADVAKWLEGSLKPQLRQFQRRMVQIESHGWQLTAEDALQVRGNLDACMSMVEQFTKFSLLNMDVVSQSWRPVRVSALLRRFAVEAMAFARQQQHEYYCNIDLVEPKAEVFLDSPQVLAILRLLLGDALQCPNMGDDGNAIVVHAELRVTVVEPQDTNQVPLSIGSPVGRVSGGGSSAGGFAGLFAPPNMSSIAPPENHSSSSSAAAAHGLRNVVASPSGSAKPSYPVIHTPVSAVQSSSEAAPLIPSGVSLPHRPLPRGHSPPLHAQKSYQHHGSDTVLPNHSHDSPLVALVSEKAPGSGGNAQGGADGSPNSAAVWPTPGSTTSSGAGMRGLPSAPISNALTSTLRRIRFELRDDGPTIPSLRGHEAVASERTHDHASPESASVDDSAALNSTSPKSASCTSERVAGDGAGDGGGLSAGLEASRSFTFAAASARRGAELEQVEKILANLGGVVYGFTRPEVPGNVVRVELPLLVVPGSTDDGRDEENGGGGGGGGTAAPPSSATRTFTVIVADSNRLHQQQLCRVLWARQHAVVPVTSFRDLGRKLEMNTADILLIDPLHIDIASEDYESLLGDDPFDDIRVLSARLALVVMASDFSDWRVQKLLNRHAVVELPKVGSGALVHIAMQEAEQLVTEMRDEEERLDLIRRTFTNSSTERHKIGKRIGKGAFGDVFEVEDTLTGGKMAMKRMRLHDGLLADEVVQEILAMTTLTHENIIQYFYCEKESDTLLRLYMELAPGGTLRDKIRETPGVPLPFEEIVHHLSCICHGLAYVHEKSYVHGDLKTANLLLGTRNRTKIGDFGTAKHLAPHQLLYTMVGTPQYMAPEVLTADVEQRLGYDFKADIWSLGCIVLEMATGSPPFAHMECAQGMGIIKYLTELTDTPDLSPLFSGNPLVYEFVKSCLDVDPQNRPTAQELLHFDILEGAVASQRAERLVRRAEMLYKLNKYAAMRADGGGGGTGRNTSGSGGGRGGAARGGGHDGSEDSEEAEGDDGNHSSLYDSGVLFSSSDSTAYEEEYDDEDDYDENDELSEHDSAEDVMENDSVPREKRDRQHSPPTSSSPAFMPEGAK
Atome Classification :
(21 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320......1330......1340......1350......1360......1370......1380......1390......1400......1410......1420......1430......1440......1450......1460......1470......1480......1490......1500......1510......1520......1530......1540......1550......1560......1570......1580......1590......1600......1610......1620......1630......1640......1650......1660......1670......1680......1690......1700......1710......1720......1730......1740......1750......1760......1770......1780......1790......1800......1810......1820......1830......1840......1850......1860......1870......1880......1890......1900......1910......1920......1930......1940......1950......1960......1970......1980......1990......2000......2010......2020......2030......2040......2050......2060......2070......2080......2090......2100......2110......2120......2130......2140......2150......2160......2170......2180......2190......2200......2210......2220......2230......2240......2250......2260......2270......2280......2290......2300......2310......2320......2330......2340......2350......2360......2370......2380......2390......2400......2410......2420......2430......2440......2450......2460......2470......2480......2490......2500......2510......2520......2530......2540......2550......2560......2570......2580......2590......2600......2610......2620......2630......2640......2650......2660......2670......2680......2690......2700......2710......2720......2730......2740......2750......2760......2770......2780......2790......2800......2810......2820......2830......2840......2850......2860......2870......2880......2890......2900......2910......2920......2930......2940......2950......2960......2970......2980......2990......3000......3010......3020......3030......3040......3050......3060......3070......3080......3090......3100......3110......3120......3130......3140......3150......3160......3170......3180......3190......3200......3210......3220......3230......3240......3250......3260......3270......3280......3290......3300......3310......3320......3330......3340......3350......3360......3370......3380......3390......3400......3410......3420......3430......3440......3450......3460......3470......3480......3490......3500......3510......3520......3530......-3540......3550......3560......3570......3580......3590......3600......3610......3620......3630......3640......3650.----.....3660......3670....--..3680......3690.....-.3700-.......3710......3720......3730......3740......3750......3760......3770......3780......3790......3800.-.....3810......3820......3830......3840......3850......3860......3870......3880......3890......3900......3910......3920......3930......3940......3950...
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MSDFSSSSSDSSSDDG
I
F
T
R
R
V
E
F
Q
Q
R
QRGASSSSSVPALGSS
A
T
R
D
V
V
A
I
I
SESAPP
C
T
V
DAVEAPATAGATTSRARSQPPDV
A
P
V
V
L
SERVTTQTSLQSASTGSEDKSSPGGS
P
V
Q
R
R
R
R
R
VAGTRPPAIKGALGSPTE
P
K
Q
Q
RGRRSSVSDPGSPLELPPPSRSS
S
R
Q
R
R
TSVHSMS
T
A
D
L
A
A
A
T
L
V
RASSNTLSTSTNKRTGGRGGGGVRRRYPRGAATT
S
L
R
ALSPVSVSPT
A
S
A
V
N
A
R
LLSD
E
A
Y
L
D
M
F
H
I
P
A
L
I
A
Q
L
S
L
S
L
MAAKPI
D
P
R
A
F
T
R
D
W
L
A
D
R
LVSEEDEDDDNADDGGGSTNSGSGAREQGSQVPPSD
T
A
V
L
T
RSTELPSS
T
S
F
V
F
QASGSTMGDFASDSGAAR
P
C
L
T
E
V
S
YRQGRSGQ
H
S
R
Q
RRRTNTSGED
E
A
D
D
V
A
KTPLEADSDGDKT
G
T
V
IDRPASV
G
H
A
S
R
K
R
R
A
F
E
R
R
A
Q
R
K
D
R
QSVATP
S
E
SRQRGVCGISNG
A
E
S
R
R
N
EMSASSRNNTSDDAYSRSPRC
G
S
L
L
TTLAPP
P
A
E
A
CEHREPRAAECEASSPM
Q
R
S
E
E
A
ERNATAAAPSSLPPTPKTSSSSSPSSSSSS
F
T
A
FRSPGSDG
V
E
W
A
R
V
E
L
QSRRTTVAGSSASADVDIPSSH
R
R
M
T
MESESSTSTEGLSAPHGTTH
G
E
H
E
V
R
QSSSSSRA
A
E
T
AVNDV
P
A
L
V
T
V
ERKGIHKSCSSSSSSSAGDG
A
H
G
L
A
A
L
A
HDRVGHTSG
R
A
I
E
L
S
T
A
A
S
S
MIRP
E
A
S
V
A
KRGA
A
K
E
E
FSRSDNEAEEGGE
A
E
R
HSNY
V
A
A
DIAEPAHSTTRGSEKD
A
A
D
A
A
A
A
A
A
E
SHGRDGDDDFS
F
A
M
F
V
P
I
L
A
VDATT
N
E
V
I
D
Y
R
EAGVSPPSAPAFSPTSGGACALPSYPTVSASGVGGGH
L
A
QTHT
S
T
A
VTQSSGFPPYATRPVSSTFNVLP
T
P
M
L
A
D
L
VGGGGLTNTSFGRRGVPNTSFGRRPAPMAGAAGRYVDPAAGAMTGSSSPPA
P
F
ITPHAPMDLPALGVSDGVVDGESLEN
L
Q
L
LGFPKLNSN
L
A
A
V
S
VG
S
V
T
GVRTS
G
S
V
V
V
AGEAA
S
V
R
E
RKAVQDDDVADSNRA
A
P
S
A
F
C
Q
S
A
V
L
HGATDGARNTN
L
S
LTKDTLG
P
V
V
A
LSTASSP
V
S
S
T
M
K
L
E
S
A
R
R
L
G
K
L
L
D
QLP
A
A
K
Y
A
A
A
I
V
F
L
E
G
L
L
SSSGGSSDAAATPESE
S
I
S
M
M
TNIGDASNRNR
G
L
L
N
LTSTAADTTLGSVGLSGDGSS
P
L
V
G
SITPGRPWSGTFGPGRSPTG
R
A
R
S
F
A
H
LVAGGSSQA
P
A
L
AASGRNEDGA
G
A
L
A
M
V
SRAPEGGHSRSRSKGG
S
T
S
V
E
A
L
V
R
D
A
L
S
Q
S
V
L
R
SLPP
T
H
EEVPGSVPSL
P
L
R
L
E
V
SGRGAGEGTSMGMHRVPSPTRLENTHG
E
R
F
A
STATSTARANTSRGSSP
V
P
VVPGGGSD
D
V
T
L
QHPPSQSERSN
L
S
F
YKQPSST
D
M
S
N
L
R
RRSSSPSPGG
Y
A
L
T
A
A
A
L
Q
Q
Q
Q
Q
S
QQQPVT
R
K
A
T
E
D
R
L
G
S
A
V
A
T
M
L
P
Q
SLSGPPPLSPAGNSS
L
A
TTGISVSE
Q
K
L
M
G
V
AVPTQPGASCVADHDEATTPEHSTARTATAADARGADSGNEDHQGAAFGGSDSC
D
L
G
S
Y
A
A
Q
Q
R
Q
N
Q
A
L
Q
H
HHGIVSSSDQS
L
A
AHATDQ
N
T
V
D
R
FATTGAAAEAAEPSATVAPKAL
E
G
T
Q
R
RCSNGNG
G
S
L
L
L
L
EQRGARGDGDESTLPPECGTHEQFMPLDAAAN
P
I
S
L
HTH
S
A
E
S
V
S
S
LSSGTAPITNSGADGGGGRRAGNAPGYWPGTFGNSQVSGSAAAEA
P
Q
ERP
Q
S
G
R
E
L
C
S
S
A
AKSSSASAGGSSG
V
V
GWGGTVSDSPSPPLHAHHPHSAG
R
E
L
E
F
EDVNL
G
A
T
L
R
M
A
V
A
L
A
AAAGTQ
S
A
R
T
V
YGSHSSSKDSMNGPAIKSSTPNQSA
G
V
A
V
VSGA
N
V
V
TADPFASA
D
A
NE
G
L
S
S
LATA
D
E
T
Y
V
N
D
L
F
V
THSSQSPPTLHGNNHK
P
L
L
R
M
VDGSGAG
E
D
C
VSLPS
S
Q
T
V
S
L
L
N
T
C
S
S
S
VAEGGDVSA
A
T
ASILPPAIP
P
V
A
VSADG
T
V
L
AT
P
I
T
AAM
T
P
I
I
LEPSTQSPPRSELP
M
V
T
S
S
V
V
V
A
M
N
S
F
FSREDHV
A
P
E
E
L
E
V
V
R
E
V
V
A
H
Y
D
A
FASL
D
E
T
Q
L
E
T
L
V
R
T
M
G
R
M
E
L
Q
RG
A
T
V
VREGD
S
T
L
G
Q
L
L
L
I
VS
G
K
L
T
I
SRKG
L
V
T
RTLARG
Q
F
Y
G
E
M
E
M
S
Y
H
V
E
R
S
R
V
T
L
TAAT
P
T
V
V
L
Y
A
L
K
KV
D
Y
Q
K
L
V
I
H
E
K
DA
R
R
Y
M
F
L
Q
Y
V
N
E
C
V
L
FKGL
S
P
Y
I
K
M
R
LAD
S
F
R
V
C
R
LRKGTKLTEQGAS
V
E
W
M
Y
L
L
MSG
N
V
R
M
T
Y
QAPPSTGGETSDWPLPWRGAAP
E
E
EA
R
H
T
V
TTSHSFSNFAGST
T
L
S
E
A
H
M
S
S
AASAAAASTAAGTSTTRCGTAPSGITGSLSSSLTP
L
T
V
A
S
QL
P
S
S
A
L
L
L
S
Q
A
A
M
A
S
LNAG
A
Q
Q
Q
D
M
L
A
E
R
AA
S
S
A
E
A
C
KESP
L
I
S
M
VSPSPGAN
A
A
T
SRM
P
Q
L
L
HLPNAKAAHANSRGKSGD
H
L
A
EQGADDGPPRPNSSR
P
R
S
R
R
L
Q
S
QQDRSVSGWQGLSQPSASAAESLDTDNTKPPSPLS
T
S
A
S
V
R
Q
S
A
N
T
LLDTTPHSNAA
S
T
V
T
TSLT
N
T
A
A
A
L
AGAAGV
H
K
T
V
V
V
V
DRSKG
Q
L
VGE
T
E
F
V
F
KCKG
L
F
T
AVATTP
V
Q
A
A
R
I
S
R
L
H
F
E
A
I
M
T
R
A
V
V
E
E
M
K
R
SMLLNP
D
Y
Y
F
F
E
FTV
P
E
A
L
K
E
D
M
R
R
M
L
F
RLNVG
P
A
A
R
R
R
T
R
H
A
Q
Q
H
Q
R
L
R
H
S
VTGV
E
G
TVSGSRSRGGTAGGNR
D
S
E
A
G
R
R
H
C
R
Q
S
M
V
L
S
R
R
T
Q
R
E
H
N
R
A
S
F
MDNITGGPGGSSNGPNGTTGSSGSNSHSTSP
P
L
V
A
V
C
VQDGGRERNDGSTSQVGSKRHHAGHRRFRTAPLEIS
P
T
M
A
R
LSTERATADSVDAAGMESS
A
L
H
Y
LAAPTVCGGPFASPAV
A
S
T
A
V
V
SSTSAGEDSVSFTPAP
A
A
TMGSMGNVKGRGSSSDGDH
N
R
Y
S
R
A
T
A
R
L
TTAGRRTSFTKHSS
T
T
T
S
I
R
R
R
VSTR
G
E
I
V
FSGSRN
L
Y
R
F
T
A
E
A
MSMNE
S
I
V
I
A
V
V
VD
G
T
I
I
R
W
N
S
V
A
Q
SVTGYA
P
F
E
A
I
G
K
S
V
F
D
F
I
VSED
G
R
Q
H
M
R
D
T
L
A
V
A
A
R
FAG
R
W
E
Q
YNMRG
L
Q
EQRV
F
P
FRQNAG
L
Y
Q
V
G
L
A
L
S
VIPSNYAK
T
A
E
V
L
L
L
IGREG
K
Y
R
A
A
S
T
Y
A
A
D
V
A
K
W
L
E
GSL
K
P
Q
L
R
Q
F
Q
R
R
M
V
Q
IESHG
W
Q
L
T
A
E
D
A
L
Q
VRG
N
L
D
A
C
M
S
M
V
E
Q
F
T
K
F
S
L
L
N
M
D
V
VSQSWR
P
V
R
V
S
A
L
L
R
R
F
A
V
E
A
M
A
F
A
R
Q
Q
Q
H
E
Y
Y
CN
I
D
L
VEP
K
A
E
V
FLD
S
P
Q
V
L
A
I
L
R
L
L
LG
D
A
LQCPNMGDDG
N
A
I
V
V
H
A
E
L
R
V
T
V
VEPQDTNQVPLSIGSPVGRVSGGGSSAGGFAGLFAPPNMSSIAPPENHSSSS
S
A
A
A
A
H
G
L
R
N
V
VASPSGSAKPSY
P
V
I
HT
P
V
S
A
VQSSSEAAPLIPSGVSLPHRPLPRGHSPPL
H
A
Q
K
S
Y
QHHGSDTVLPNHSHDS
P
L
V
A
L
VSEKAPGSGGNAQGGADGSPNS
A
A
VWPTPGSTTSSGAGMRGLPSA
P
I
S
N
A
L
T
S
T
L
R
R
I
R
F
E
LRDDGPTIPSLRG
H
E
A
V
ASERTHDHASPESASVDDSAALNSTSPKSASCTSERVAGDGAGDGGGLSAGLEASR
S
F
T
F
A
AASARRGA
E
L
E
Q
V
E
K
I
L
A
NLG
G
V
V
Y
GFTRPEVPG
N
V
V
R
V
EL
P
L
L
V
VPGSTDDGRDEENGGGGGGGGTAAPPSSA
T
R
T
F
T
V
I
V
ADSNRL
H
Q
Q
Q
L
C
R
V
L
W
ARQHAVVP
V
T
S
F
R
D
L
G
R
KLEMNTA
D
I
L
L
ID
P
L
H
I
DIA
S
E
D
Y
E
S
L
LGDDP
F
D
D
I
R
V
L
S
A
R
L
A
L
V
V
M
ASDF
S
D
W
R
V
Q
K
L
L
N
R
H
A
V
V
ELPKVGS
G
A
L
V
H
I
A
M
Q
E
A
E
Q
L
V
T
E
MR
D
E
E
E
R
L
D
L
I
R
R
TFT-NSS
T
E
R
H
K
I
G
K
R
IGKGAFG
D
V
F
E
VEDTLT
G
G
K
M
A
M
K
R
M
R
LHDG
L
L
A
D
E
V
V
Q
E
I
L
A
M
T
TL
T
H
E
N
I
I
Q
Y
F
Y
CEKES
D
T
L
L
R
L
Y
M
E
LAPGG
T
L
R
D
K
I
RETPGVPL
P
F
E
E
I
V
H
H
L
S
C
I
C
----
H
G
L
A
Y
V
HEKSYVHGDL
K
T
A
N
L
L
L--GTRNRTKIGDFGTAKHL
A
P
H
Q
-
L
L
Y
-
T
-MVGTPQYMA
P
E
V
L
T
A
D
V
E
Q
R
LGYDFK
A
D
I
W
S
L
G
C
I
V
L
EMATGSPP
F
A
H
M
E
C
A
QGM
G
I
I
K
Y
L
T
E
LTDTPDLSPLFSGN
P
L
V
Y
E
F
V
K
S
C
LDVDPQNRP
T
A
Q
E
L
L
-
H
F
D
I
L
E
G
A
V
A
S
Q
R
A
E
R
L
V
R
R
A
E
M
L
Y
K
L
N
K
Y
A
A
M
RADGGGGGTGRNTSGSGGGRGGAARGGGHDGSEDSEEAEGDDGNHSSLYDS
G
V
L
FSSSDSTAYEEEYDDEDDYDENDELSEHD
S
A
E
D
V
M
ENDSVP
R
E
KRDRQHSPPTSSSPAFMPEGAK
2
PsiBlast_PDB
79.13
35%
-44
- C1 -
-
4U8Z
1
STK24_HUMAN
A:
[20-282]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
--
P
G
-
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
----
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
--
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
-
I
K
R
-
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
----
V
L
F
L
I
P
K
N
N
P
P
T
L
E
G
N
Y
S
-
K
P
L
-
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
78.13
31%
0
- C- -
-
1F3M
-
?
C:
[2-276]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
R
Q
M
N
L
Q
Q
Q
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
-
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
-----
C
M
D
E
--
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
--
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
--------
T
-
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-----
R
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
----
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
D
M
D
V
E
K
R
G
S
A
K
E
L
L
-
Q
H
Q
F
L
K
I
A
------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
78.09
35%
-40
- C1 -
-
3A7F
-
STK24_HUMAN
A:
[28-290]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
--
P
G
-
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
----
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
--
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
-------
R
-
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
----
V
L
F
L
I
P
K
N
N
P
P
T
L
E
G
N
Y
S
-
K
P
L
-
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
78.04
35%
-41
- C1 -
-
4W8D
1
STK24_HUMAN
A:
[20-282]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
--
P
G
-
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
----
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
--
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
-
I
K
R
-
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
----
V
L
F
L
I
P
K
N
N
P
P
T
L
E
G
N
Y
S
-
K
P
L
-
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
78.02
35%
-43
- C1 -
-
4QML
2
STK24_HUMAN
A:
[35-297]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
--
P
G
-
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
----
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
--
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
-
I
K
R
-
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
----
V
L
F
L
I
P
K
N
N
P
P
T
L
E
G
N
Y
S
-
K
P
L
-
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
77.26
35%
-39
- C1 -
-
4W8E
1
STK24_HUMAN
A:
[20-282]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
--
P
G
-
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
----
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
--
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
-
I
K
R
-
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
----
V
L
F
L
I
P
K
N
N
P
P
T
L
E
G
N
Y
S
-
K
P
L
-
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
77.25
35%
-41
- C1 -
-
3A7J
1
STK24_HUMAN
A:
[28-290]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
--
P
G
-
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
----
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
--
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
-
I
K
R
-
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
----
V
L
F
L
I
P
K
N
N
P
P
T
L
E
G
N
Y
S
-
K
P
L
-
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
76.86
30%
-78
- C1 -
-
4XBR
1
INKA1_HUMAN (first)
A:
[92-353]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
Q
Q
R
R
E
L
L
F
N
E
V
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
-
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
T
---
R
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
----
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
--
T
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
P
R
R
K
-
S
-
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
R
-----
L
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
----
L
P
P
R
L
K
N
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
-
K
H
P
F
L
A
K
A
G
P
P
---------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
76.48
35%
-43
- C1 -
-
3CKX
1
STK24_HUMAN
A:
[13-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
--
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
--
P
G
-
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
----
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
--
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
-
I
K
R
-
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
----
V
L
F
L
I
P
K
N
N
P
P
T
L
E
G
N
Y
S
-
K
P
L
-
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
76.04
35%
-43
- C1 -
-
4O27
1
STK24_HUMAN
B:
[12-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
--
P
G
-
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
----
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
--
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
-
I
K
R
-
N
E
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
----
V
L
F
L
I
P
K
N
N
P
P
T
L
E
G
N
Y
S
-
K
P
L
-
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
75.96
35%
-41
- C1 -
-
3A7I
1
STK24_HUMAN
A:
[28-290]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
--
P
G
-
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
----
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
--
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
-
I
K
R
-
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
----
V
L
F
L
I
P
K
N
N
P
P
T
L
E
G
N
Y
S
-
K
P
L
-
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
75.96
35%
-40
- C1 -
-
3A7G
-
STK24_HUMAN
A:
[28-290]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
--
P
G
-
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
----
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
--
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
-
I
K
R
-
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
----
V
L
F
L
I
P
K
N
N
P
P
T
L
E
G
N
Y
S
-
K
P
L
-
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
75.88
35%
-40
- C1 -
-
3A7H
1
STK24_HUMAN
A:
[28-290]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
--
P
G
-
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
----
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
--
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
-
I
K
R
-
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
----
V
L
F
L
I
P
K
N
N
P
P
T
L
E
G
N
Y
S
-
K
P
L
-
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
75.66
35%
-39
- C1 -
-
4QMM
3
STK24_HUMAN
A:
[35-297]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
--
P
G
-
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
----
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
--
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
-
I
K
R
-
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
----
V
L
F
L
I
P
K
N
N
P
P
T
L
E
G
N
Y
S
-
K
P
L
-
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
74.47
30%
-78
- C1 -
-
5J5T
1
M4K3_HUMAN
A:
[3-271]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
D
F
E
L
I
Q
R
I
G
S
G
T
Y
G
D
V
Y
K
A
R
N
V
N
T
G
E
L
A
A
I
K
V
I
K
L
E
P
G
E
D
F
A
V
V
Q
Q
E
I
I
M
M
K
D
C
K
H
P
N
I
V
A
Y
F
G
S
Y
L
R
R
-
D
K
L
W
I
C
M
E
F
C
G
G
G
S
L
Q
D
I
Y
H
V
T
--
G
P
L
S
E
L
Q
I
A
Y
V
S
R
E
T
L
----
Q
G
L
Y
Y
L
H
S
K
G
K
M
H
R
D
I
K
G
A
N
I
L
L
--
T
D
N
G
H
V
K
L
A
D
F
G
V
S
A
Q
I
T
A
T
I
A----
A
-
F
I
G
T
P
Y
W
M
A
P
E
V
A
A
V
E
--
R
K
G
G
Y
N
Q
L
C
D
L
W
A
V
G
I
T
A
I
E
L
A
E
L
Q
P
P
M
F
D
L
H
P
M
R
A
L
F
L
M
--
T
K
S
N
F
Q
P
P
K
L
K
D
K
M
K
W
S
N
S
F
H
H
F
V
K
M
A
L
T
K
N
P
K
K
R
P
T
A
E
K
L
L
-
Q
H
P
F
V
T
Q
H
L
T
R
---------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
72.60
35%
-42
- C1 -
-
3ZHP
-
STK24_HUMAN
C:
[33-293]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
--
P
G
-
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
----
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
--
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
----
R
N
T
-
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
----
V
L
F
L
I
P
K
N
N
P
P
T
L
E
G
N
Y
S
-
K
P
L
-
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
--------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
72.53
31%
-17
- C1 -
-
1YHW
-
PAK1_HUMAN
A:
[250-524]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
R
Q
M
N
L
Q
Q
Q
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
-
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
-----
C
M
D
E
--
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
--
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
E
Q
S
K
R
S
-
T
-
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-----
R
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
----
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
D
M
D
V
E
K
R
G
S
A
K
E
L
L
-
Q
H
Q
F
L
K
I
A
------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
71.10
31%
-20
- C1 -
-
1YHV
-
?
A:
[250-524]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
R
Q
M
N
L
Q
Q
Q
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
-
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
-----
C
M
D
E
--
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
--
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
E
Q
-
S
K
R
-
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-----
R
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
----
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
D
M
D
V
E
K
R
G
S
A
K
E
L
L
-
Q
H
Q
F
L
K
I
A
------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
70.54
29%
-64
- C1 -
-
2X4F
4
MYLK4_HUMAN
A:
[89-351]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
V
S
K
T
E
I
L
G
-----
Q
V
H
K
C
E
E
T
A
T
G
L
K
L
A
A
K
I
I
K
T
R
G
M
K
D
K
E
E
V
K
N
E
I
S
V
M
N
Q
L
D
H
A
N
L
I
Q
L
Y
D
A
F
E
S
K
-
N
D
I
V
L
V
M
E
Y
V
D
G
G
E
L
F
D
R
I
I
D
E
S
-
Y
N
L
T
E
L
D
T
I
L
F
M
K
Q
I
C
----
E
G
I
R
H
M
H
Q
M
Y
I
L
H
L
D
L
K
P
E
N
I
L
C
VN
R
D
A
K
Q
I
K
I
I
D
F
G
L
A
R
R
Y
K
P
R
E
-
K
L
K
-
V
-
N
F
G
T
P
E
F
L
A
P
E
V
V
N
Y
-----
D
F
V
S
F
P
T
D
M
W
S
V
G
V
I
A
Y
M
L
L
S
G
L
S
P
F
L
G
D
N
D
A
E
T
L
N
N
I
L
A
C
R
---
W
D
L
E
D
E
E
F
Q
D
I
S
E
E
A
K
E
F
I
S
K
L
L
I
K
E
K
S
W
R
I
S
A
S
E
A
L
-
K
H
P
W
L
S
D
H
K
L
----------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
68.97
31%
-29
- C1 -
-
4ZJI
1
PAK1_HUMAN
A:
[8-278]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
-----
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
-
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
-----
C
M
D
E
--
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
--
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
-------
T
-
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-----
R
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
----
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
-
Q
H
Q
F
L
K
I
A
------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
62.53
31%
-17
- C1 -
-
4ZLO
2
PAK1_HUMAN
A:
[2-276]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
--
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
-----
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
-
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
-----
C
M
D
E
--
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
--
G
M
D
G
S
V
K
L
T
D
F
G
----------
S
K
R
-
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-----
R
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
----
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
-
Q
H
Q
F
L
K
I
A
------------------------------------------------------------------------------------------------------------------------------------------------