@TOME V2.3
(Mar 2018)
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Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
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Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
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3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
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Structural Clustering:
Cluster Num
3D-Jury Struct. Score
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Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
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Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
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Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
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Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_20_0970: (2018-03-09 )
MAQTLCGCPFAEVMCPVLVMESSRARIAAAAIRNPDPASSSAMTVDPDTQRQGLPLTLGRPPHSGSSSSSLRHLDSPQPLASNATVLDRKEDDMAEDSRGTYHQAAAAAANGDASDAGVDDEGGPETNSAPASRILKSISKTLMGRASSSSHNTTTNAVTMATSTAATATGTFTPNHSALPLEKLNSDSPTPPPPCAWSLVYANDAAASMLGCSSVDEVTTAAFDNLLCCFALTLPPSASAGSVRSSMPLVTAAAATDGASVPFALASLPATASSSSPQAACFGEKEMASNDENDDKGRQKHQQPSSNAVQQPGWREVQNPGELFALPNHNYVILYSKRTSAYYAALAVPSHQPKMSQRTSVDGESTPRMGSPSTMRNQSLCPTIQQAECYPPVPRNPSHPSADVPSSRLTGSEEATGMAQCGRRTSTILAAANTSSPFEPDLSDGASPPPPMQQQRCSRYVEIYILQRLESSHRPAGIARMPTARAVAAGPPPTLVTLGSGAADARGPGARTATSPGDHRSTAVFTPPPAEAPHLRSPQQLPPPPHRPPRSALSNSATAAAVTETGSVDSLDVDAPRPLREQYANRSQHASLHPMVQSQRRLPSSSTERSSNWAASRTSGHPGSPAPGVQVTFGSPETPSANSDAASAMRSSSQHTNQNSLYDLSYPAFHVNLAQPTITSTDCLYGANEPAGAAPLAAAVAGGSRGLPLTPLHKPGEDPHHNYSSPNSSSTPLQKTASNARQPQPEQRHLLSRQRQHRPLAGLVDDEDEARAVTRFKRSSMNNSLPISPALQPASGPASRQRSLSSAPLSATSTTIALLSCARSRMLSPLYQQLPPPSSGRVSSSGSARLQSPAASTAALAPAVTPPAPRRAMQEARDVESVVQLAQQVRAEQQPYRKNKAGQLVAFARGSPPSAWAHRDSQPLSPLSLSLFHSHASLVHRSPHSGGHHSLVSGGDAAGLSEYSLPHHTFPSAVTGCLLQQPQPSGWASPMETSAAQMLGNVAGMSWQRSNEVDQITPHKLADRVRSQRGVVAVLVSARLPHTIIFNSVAFMMFVQHVLRFQRRNGATQVACILNVCRKMQLVIHMIPVEVLPGASGCVKRTGADNGSPSTNSASPASRRVSVSWKANNGNAEGADGNSSTVTEAVWALSKLNATLPSPHEANPAGHHLLGSLPSSAPATSSQQQQRMIVELLRARLEDLDVLYGYEELMEAFSPAAPALDSSVRGFIPSHSSSGSGPFTNSNSSCAPPTATASSLGTGIVASSPPWGSMQHYSTQASPLHSPSGGSKESRTATPQRSVQSLLATNAVPRHPHRDPLRCSRAWSCSPHLQQQAHDRNASTTPSVTAVQKVALVSNAASSGGDRRDSRRRSTSGNLGTCSGTDRLSKRSSAMRSSGDSVSNGALSRRSSFMTRTTAATAATAAAAAAAAAAAVRAADSVQRKGSFAMLSGAAAHAADGSRAASVVLSRASNPASTTASGTADAAREGGNSSILTSNTTAASHTFDPAFSEVRALGMQQNTGEEGDDTLSRQRTRMENGESSDEVIETAAESSPTSLPSRRTGSVKQSLLWAYPGAGSASQAPQPQHRRLPPRYVSSSSYLSRDMRESLAMCDAATRIRADTYEARVLIPFTTPQRLELLSRLGNVQLSKYRGLSVFGVNLVNLVTEEAAAEAAQPSPPIIPLRYDIAARTYLEGVRGKSVIFSPLMSPTTAAPSFPSKSARASADVKEAKAEPTEAESAVANTAAAKMSSADTLSEAAAPAAGAAVSMALRLRPPPLQALASSAAGAPGIAVPVVSAVTSATMSSLSARSRGESSAFSSGAAGQKVAPLEAANPSGFSTTQHGSASGSEGTSPEGVDDDTLRRGSGATASGEATPTQRHADPFQLPMDSSPTGGTHHGTYRGLLTLSMKSKDDGEDGHFSASVVAATAAHAEAAKGMEDGKKRISDNVGRCAKQLHEGRTLRAAASFSVLTVSSGSLPRKGTGLQLPAVLLDGTIAAAEGKSRSTAVAKTEKEQLTAHARTTTQRASMEITSPLRRGSRDAAPVGETRSTANTAVTVSTAVMRSPPQRHGPQRNLTPHSCHHAVELSAQSGTLQTPLHVALPFAESWSAGLQSPPVSQGSNILSASCAAGVSGASITADSSADRTTRSSRSGTPSTQSRPSVPYPSSLPHPIVSCTAPFAAGNNNPTEPASTQSSKTQGLVSVCTQKSGGTELLGYALSNSAAAAFGDLSTALKKEDNEHAGSSARASSTENKEEAKKATVNATALLEPLAVGAPETKRHTQQYANPASLSGQAPESVIVADISAHAALPSISFATLTGTAAAQSTTAEEGDAMTSTMEVKLSGVSADNGEHKSSGNLGNLVAPVATGNGGAGASDDRRAPAGGGNANMPDEANDSFADSFMDIFGLVNRPQQLADLRRCVSMHVRSVCDHGFLSTGSSSMSSGATTNAVAAAAAVQGNTSSSSTGNRGWGAAVAAQPIRPLTAFVSSPSESRVDEGVRSSESSKLRRIAGLSNIAATAEKGATPYENAAMRAVAEDAADQTTRNNLHVLVYTTRAYAEVEEVLGIYGHCTTFVTSATKMLRYARSGLQLFDVVIVEWVESLISGEMHDTLAKHAVEETVVAFFISTRPGVRTPTMNVDNIMTDATVVMYADNLLEGLLSRNVLEEVQQLIRRRRLLRSMVGVRKEQSYQIVSHIGSGAFGDVFEVMMYVSRGRLAMKRIFLKSMKLRQLEIINREVSIMRSLEHPNIVSFSHTRLEDNAYAIFMELCDATLANHLLEPSVAIPGAAQRQQYRSAGLMAGYPDNAMNNSSNSVSGNGVDVAGMLQAAAREGGRTEFPGAHGASIMTPELKRPQDAVMIVHDIASALIYLHRRGIIHRDIKPANVLFANGMAKLGDFGSAVKMTESRQLRNMKGTVSYMAPEMVLGEPYTESCDLWSFGCLIARIMGINLGHLNGLHMPALNELYRAIPKTGSLPLTFTNRLSSRFGHHFTEETTSRVLKALKHAIEIDMAERQLAASPNSHNSVDANSTVEDKEMQSSSQQTTSIGSDASLCTDTASMTSERESRHATEPDGTGTATSEADTQNSRRSILCITTSDIVVLGEFFVLLPASLVDLFNRLFHRDPAKRMTAAEVLDHQVSWDVEWMARMMQEIYEVSCLIEQRSAGAQGAAGGASRFHLAGQAGGGRLPRGEEGAGTGVATPSMTAGNFAHFPIQPGSGELAWMTGGSGGQRVLGAAGTGSGANILSAANNYVLDLSLSSSSSGSGGRGSKDEASDD
Atome Classification :
(22 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320......1330......1340......1350......1360......1370......1380......1390......1400......1410......1420......1430......1440......1450......1460......1470......1480......1490......1500......1510......1520......1530......1540......1550......1560......1570......1580......1590......1600......1610......1620......1630......1640......1650......1660......1670......1680......1690......1700......1710......1720......1730......1740......1750......1760......1770......1780......1790......1800......1810......1820......1830......1840......1850......1860......1870......1880......1890......1900......1910......1920......1930......1940......1950......1960......1970......1980......1990......2000......2010......2020......2030......2040......2050......2060......2070......2080......2090......2100......2110......2120......2130......2140......2150......2160......2170......2180......2190......2200......2210......2220......2230......2240......2250......2260......2270......2280......2290......2300......2310......2320......2330......2340......2350......2360......2370......2380......2390......2400......2410......2420......2430......2440......2450......2460......2470......2480......2490......2500......2510......2520......2530......2540......2550......2560...-...2570......2580......2590......2600......2610......2620......2630...--...2640......2650......2660......2670......2680.--.---...-------------------------.2690......2700......2710......2720...---.----..-2730.........2740......2750..--...-----.2760......2770........-2780......2790......2800......2810......----------2820......2830......-2840......2850.....-.2860......2870......2880...--.---.-----.-----2890---........2900----.-...-...-2910......2920--.---.------..-.-.2930......2940..------------....2950......2960......2970......2980......---2990------......-------..3000..----....3010....----------...3020......3030.....--.3040.....---.3050......3060......3070......3080----.......3090......3100......3110......3120......3130......3140......3150......3160......3170......3180......3190......3200......3210......3220......3230......3240......3250......3260......3270..
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MAQTLCGC
P
F
A
E
V
M
C
P
V
L
V
MESSR
A
R
I
A
A
A
AIRNPDPASSS
A
M
T
VDPDTQRQGLPLTLGRPPHSGSSSSSLRHLDSPQPLASN
A
T
V
LDRKEDDMAEDSRGT
Y
H
Q
A
AAAAANGDASDAGVDDEGGPETNS
A
P
A
S
R
I
L
K
S
I
S
K
T
L
MGRASSSSHNTT
T
N
A
V
T
M
A
TSTAA
T
A
T
G
TFTPNHSAL
P
L
E
KLNSDSPTPPPPC
A
W
S
L
V
YAN
D
A
A
A
S
M
LGC
S
S
V
D
E
V
T
T
A
A
F
D
N
L
L
C
C
F
A
LTLPPSASAGSVRSSM
P
L
V
T
A
AAATDGASV
P
F
A
L
ASLPATASSSSPQ
A
A
CFG
E
K
EMASNDENDDKG
R
Q
KHQQPSSNAVQQPGWREVQNPG
E
L
F
A
LPNH
N
Y
V
I
L
Y
SKRT
S
A
Y
Y
A
A
L
AVPSHQPKMSQRTSVDGESTPRMGSPSTMRNQSLCPTIQQAECYPPVPRNPSHPSADVPSSRLTGS
E
E
A
T
G
M
A
Q
CGRR
T
S
T
I
L
A
AANTSSPFEPDLSDGASPPP
P
M
Q
Q
Q
R
C
S
R
Y
V
E
I
Y
I
L
Q
R
L
E
SSHRPAGIARMPTARAVAAGPP
P
T
L
V
T
LGSGAADARGPGARTATSPGDHRS
T
A
V
FTPPPAEAPHLR
S
P
QQLPPPPHRP
P
R
S
ALSNSA
T
A
A
A
V
TETGSVDSLDVDAP
R
P
L
R
E
Q
Y
ANRSQHASL
H
P
M
V
Q
S
Q
RRLPSSSTERSSNWAASRTSGHPGSPAP
G
V
Q
V
T
FGSPETPSAN
S
D
A
A
S
A
M
R
SSSQHTNQNS
L
Y
DLSYP
A
F
H
V
NLAQPTITSTDCLYGANEPAGAA
P
L
A
A
A
VAGGSRGLPLTPLHKPGEDPHHNYSSPNSSST
P
L
Q
K
TASNARQPQ
P
E
Q
R
H
L
L
S
R
Q
R
QHRPLAGLVDD
E
D
E
A
R
A
V
T
R
F
K
R
SSMNNSLPISPALQPASG
P
A
S
R
QRSLSSAPLSA
T
S
T
T
I
A
L
L
S
C
A
R
S
R
M
L
S
P
L
Y
Q
QLPPPSSGRVSSSGSARLQSPAASTAALAPAVTPPA
P
R
R
A
M
Q
E
A
R
D
V
E
S
V
V
Q
L
A
Q
Q
V
R
A
EQQPYRKNKAG
Q
L
V
A
F
ARGSPP
S
A
WAHRDSQPLS
P
L
S
L
S
L
F
H
S
H
A
S
L
V
HRSPHSGGHHSLVSGGDAAGLSEYSLPHHT
F
P
S
A
V
T
G
C
L
LQQPQPSGWASP
M
E
T
S
A
A
Q
M
L
G
N
VAGMSWQRSNEVDQI
T
P
H
K
L
A
D
R
V
R
SQR
G
V
V
A
V
L
VSARLP
H
T
I
I
F
N
S
V
A
F
M
M
F
V
Q
H
V
L
R
F
Q
RRNG
A
T
Q
V
A
C
I
L
N
V
C
R
K
M
Q
L
V
I
H
MI
P
V
E
VLPGASGCVKRTGADNGSPSTNSASPAS
R
R
V
S
V
S
W
K
ANNGNAEGADGN
S
S
T
V
T
E
A
V
W
A
L
S
K
L
NATLPSPHEANPA
G
H
H
L
L
GSLPSSAPAT
S
S
Q
Q
Q
Q
R
M
I
V
E
L
L
R
A
R
L
E
D
L
D
V
L
Y
G
Y
E
E
L
M
E
AFSPAAPA
L
D
S
S
V
R
G
FIPSHSSSGSGPFTNSNSSCAPPTA
T
A
S
SLGTGIVASSPPWGSMQHYSTQASPLHSPSGGSKESRTAT
P
Q
R
S
V
Q
S
L
L
ATNAVPRHPHRDPLRCSRAWSCS
P
H
L
Q
Q
Q
AHDRNASTTP
S
V
T
A
V
Q
K
V
A
L
VSNAASSGGDRRDSRRRSTSGNLGTCS
G
T
D
R
L
S
K
R
S
S
A
M
RSSGDSVSN
G
A
L
S
R
R
S
S
F
M
TRTTAA
T
A
A
T
A
A
A
A
A
A
A
A
A
A
A
V
R
A
A
D
S
V
QRKG
S
F
A
MLSGAAAHAADG
S
R
A
A
S
V
V
L
SRASNPASTTASGT
A
D
A
A
REGGN
S
S
I
L
TSNTTAASHTFD
P
A
F
S
E
V
R
A
LGMQQNTGEEG
D
D
T
L
S
R
Q
R
T
RMENGE
S
S
D
E
V
I
E
T
A
AESSPTSLPSRRTG
S
V
K
Q
S
L
L
W
AYPGAGSASQAPQPQHRRL
P
P
R
YVSS
S
S
Y
L
S
R
D
M
R
E
S
L
A
M
C
D
A
A
T
RIRADTYE
A
R
V
L
I
PFT
T
P
Q
R
L
E
L
L
S
R
LGN
V
Q
L
S
K
YR
G
L
S
V
F
G
V
N
L
V
N
L
V
T
E
E
A
A
AEAAQPSP
P
I
I
P
L
R
Y
D
I
A
A
R
T
Y
L
E
GVRGK
S
V
I
F
SPLMSPTTAAPSFPSKSARASAD
V
K
EAKAEPT
E
A
E
S
A
V
A
N
T
A
A
AKMSSAD
T
L
S
E
AAAPAAG
A
A
V
S
M
A
L
R
LRPP
P
L
Q
A
L
A
S
SAAGAPG
I
A
V
P
V
V
S
A
V
T
S
A
T
M
S
S
L
S
ARSRGESSAFSSGAAGQKVAPLEAANPSGFSTTQHGSASGSEGTSPEGVD
D
D
T
LRRGSGATASGEATPTQRHADPFQLPMDSSPTGGTHH
G
T
Y
R
G
L
L
T
L
S
MKSKDDGEDGHF
S
A
S
V
V
A
A
T
A
A
H
A
E
A
AK
G
M
E
D
G
K
K
R
I
S
D
N
V
G
R
C
A
K
Q
L
HEGR
T
L
R
A
A
A
S
F
S
V
L
T
VSSGSLPRKGTGLQL
P
A
V
L
LD
G
T
I
AAAEGKSRSTAVAK
T
E
K
E
Q
L
T
A
HARTTTQRASM
E
I
T
S
P
L
RRGSRDAAPVGETRSTAN
T
A
V
T
V
S
T
A
V
MRSPPQRHGPQRNLT
P
H
SCH
H
A
V
E
L
SAQSGTLQT
P
L
H
V
ALP
F
A
E
S
W
SAGLQSPPVSQGS
N
I
L
S
A
S
CAAGVSG
A
S
I
TADSSADRTTRSSRSGTPSTQSRPSVPYPSSLPHP
I
V
SCTAPFAAGNNNPTEPASTQSS
K
T
Q
G
L
V
S
V
C
TQKSGG
T
E
L
L
G
Y
ALSN
S
A
A
A
A
F
G
D
L
S
T
A
L
KKEDNEHAGSSARASSTE
N
K
E
E
A
K
K
ATV
N
A
T
A
L
L
E
P
LAVGAP
E
T
K
R
H
T
Q
Q
YANPASLSGQAP
E
S
V
I
V
A
DISAHAALPS
I
S
F
A
T
LTGTAAAQSTTAEEGDAM
T
S
T
M
E
V
K
L
SGVSADNGEHKSSGNLG
N
L
V
A
P
V
ATGNGGAGASDDRRAPAGGGNANMPDEAN
D
S
F
A
D
S
F
M
D
I
F
G
LVNR
P
Q
Q
L
A
D
L
R
R
C
V
S
M
H
V
R
S
V
C
DHGFLSTGSSSMSSGATTN
A
V
A
A
A
A
A
VQGNTSSSSTGNRGWG
A
A
VAAQPI
R
P
L
T
A
F
VSSP
S
E
S
R
V
D
E
GVRSS
E
S
S
K
L
R
R
I
AGL
S
N
I
A
A
T
A
EKGATPY
E
N
A
A
M
R
A
V
A
E
DAADQTTRN
N
L
H
V
L
V
Y
T
T
R
A
Y
A
E
V
E
E
V
L
G
I
-YG
H
C
T
T
F
V
T
S
A
T
K
M
L
R
Y
A
R
SG
L
Q
L
F
D
V
V
I
V
E
W
V
E
S
L
ISG
E
M
H
D
T
L
A
K
H
A
V
E
E
T
V
V
A
F
F
ISTRPGVRTPTM--
N
V
D
NIMTD
A
T
V
V
M
Y
A
D
N
L
L
E
G
L
L
S
R
N
V
L
E
E
V
Q
Q
L
I
R
R
R
R
L
L
R
S
M
V
GVR--K---E
Q
S
-------------------------
Y
Q
I
V
S
H
IGSGA
F
G
D
V
F
E
V
M
M
Y
V
SR
G
R
L
A
M
K
R
I
F
L
K
SM
K
---
L
----
R
Q
-
L
---
E
I
I
N
R
E
V
S
I
M
R
SLEHP
N
I
V
S
F
SHTR--LED-----N
A
Y
A
I
F
M
E
L
C
D
A
-
T
-
L
A
N
H
LLEP-SVAIP
G
A
A
Q
R
Q
Q
Y
R
SAGLMAGYPDNAMNNSSNSVSGNG
V
D
----------
V
A
G
M
L
Q
A
A
A
REGGRTEFPGA-HGASIMTPELKRPQ
D
A
V
M
I
-
V
H
D
I
A
S
A
L
I
Y
L
H
RRGIIHRDIKPA
N
V
L
F--A---N-----G-----
M
-
A
----KLGDFGSAVKM-----
T
-
E
S
R
-
Q
L
R
-NMKG
T
V
S
YMA
P
E
MV--L---G------EP-Y-TESCD
L
W
S
F
G
C
L
I
A
R
I
M------------GINLGHLNGLH
M
P
A
L
N
E
L
Y
R
AIPKTGSL
P
L
T
F
T
N
R
L
S
S
R
FGHHF---
T
E
--------
E
T
T
S
R
V
-------
L
K
A
L
K
H
A
I
----
E
I
D
M
A
E
R
-
Q
LAA----------SPNSHNSVDANSTV
E
D
K
E
M
QSS--SQQTTSIGSD---ASLCT
D
T
A
S
M
T
S
E
R
ESRHATEPDGTGTATSEADT-----QNS
R
R
S
I
L
C
I
TTSD
I
V
V
L
G
E
F
F
V
L
L
P
A
S
L
V
D
L
F
N
R
L
FHRD
P
A
K
R
M
T
A
A
E
V
L
D
H
QVSW
D
V
E
W
M
A
R
M
M
Q
E
I
Y
E
V
S
C
L
I
E
QRSAGAQGAAGGAS
R
F
H
L
AGQAGGGRLPRGEEGAGTGVATPSMTAGNFAHFPIQPGS
G
E
L
A
W
M
TGGSGG
Q
R
V
L
GAAGTGSGA
N
I
L
SAAN
N
Y
V
L
D
L
S
LSSSSSGSGGRGSKDEASDD
47
Fugue
76.02
16%
1
- C1 -
-
3C4Z
1
RK_BOVIN
A:
[31-533]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
C
E
A
L
R
E
S
L
D
L
G
F
E
G
M
C
L
E
Q
P
I
G
K
R
L
F
Q
Q
F
L
R
T
H
E
Q
H
G
P
A
L
-
Q
L
W
K
D
I
E
D
Y
D
T
A
D
D
A
L
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
E
P
Q
A
Q
L
F
C
S
F
L
D
A
E
T
V
A
R
A
R
A
G
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
--
Q
PMG
E
D
W
-------------------------
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
K
A
T
G
K
L
Y
A
C
K
K
L
N
K
K
R
L
K
---
K
----
R
K
G
Y
---
Q
G
A
M
V
E
K
K
I
L
A
K
V
H
S
R
F
I
V
S
L
A
Y
A
F
--
E
T
K
-----
T
D
L
C
L
V
M
T
I
M
N
G
G
D
-
I
R
Y
H
I
Y
N
V
-
D
E
D
N
P
G
F
---------------------------------------------------------------------------
Q
E
P
R
A
I
F
Y
-
T
A
Q
I
V
S
G
L
E
H
L
H
Q
R
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
-
D
---
D
-----
G
-----
N
-
V
----
R
I
S
D
L
G
L
A
V
E
L
-----
K
-
A
G
Q
T
K
T
K
-
G
Y
A
G
T
P
G
F
M
A
P
E
L
L
--
L
---
G
------
E
E
-
Y
-
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A-----------
A
R
G
P
F
R
A
R
G
E
K
V
E
N
K
E
L
K
Q
R
V
L
E
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
---
Q
K
--------
D
P
E
K
R
L
GFRDGSC
D
G
L
R
T
H
P
L
FRDI
S
W
R
Q
L
E
A
-
G
M
L
T
----------
P
P
F
V
P
D
S
R
T
V
Y
A
K
N
G
A
F
S
G
V
A
F
--
E
K
A
D
T
E
F
F
Q
E
---
F
A
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
V
W
R
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
HHSearch
67.95
28%
-119
- C1 -
-
3KK8
-
KCC2D_CAEEL
A:
[5-205]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
N
-------------------------
Y
D
V
K
E
E
L
G
K
G
A
F
S
V
V
R
R
C
V
H
K
T
T
G
L
E
F
A
A
K
I
I
N
T
K
K
L
S
---
A
----
R
D
-
F
---
Q
K
L
E
R
E
A
R
I
C
R
K
L
Q
H
P
N
I
V
R
L
H
D
S
I
--
Q
E
E
-----
S
F
H
Y
L
V
F
D
L
V
T
G
-
G
-
E
L
F
E
D
I
V
A
-
R
------------------------------------------------------------------------------
E
F
Y
S
E
A
D
A
S
H
C
-
I
Q
Q
I
L
E
S
I
A
Y
C
H
S
N
G
I
V
H
R
N
L
K
P
E
N
L
L
L
--
A
---
S
KAKG-
A
-----
A
-
V
----
K
L
A
D
F
G
L
A
I
E
V
-----
N
-
D
S
E
-
A
W
H
-
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
--
K
---
K
------
D
P
-
Y
-
S
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
------------
V
G
Y
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
66.17
28%
-115
- C1 -
-
2BDW
-
KCC2D_CAEEL
A:
[9-211]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
---
S
D
N
-------------------------
Y
D
V
K
E
E
L
G
K
G
A
F
S
V
V
R
R
C
V
H
K
T
T
G
L
E
F
A
A
K
I
I
N
T
K
K
L
S
---
A
----
R
D
-
F
---
Q
K
L
E
R
E
A
R
I
C
R
K
L
Q
H
P
N
I
V
R
L
H
D
S
I
--
Q
E
E
-----
S
F
H
Y
L
V
F
D
L
V
T
G
-
G
-
E
L
F
E
D
I
V
A
-
R
------------------------------------------------------------------------------
E
F
Y
S
E
A
D
A
S
H
C
-
I
Q
Q
I
L
E
S
I
A
Y
C
H
S
N
G
I
V
H
R
N
L
K
P
E
N
L
L
L
--
A
---
S
KAKG-
A
-----
A
-
V
----
K
L
A
D
F
G
L
A
I
E
V
-----
N
-
D
S
E
-
A
W
H
-
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
--
K
---
K
------
D
P
-
Y
-
S
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
------------
V
G
Y
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
64.15
28%
-119
- C1 -
-
2WEL
7
KCC2D_HUMAN
A:
[3-208]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
D
E
-------------------------
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
K
L
S
---
A
----
R
D
-
H
---
Q
K
L
E
R
E
A
R
I
C
R
L
L
K
H
P
N
I
V
R
L
H
D
S
I
--
S
E
E
-----
G
F
H
Y
L
V
F
D
L
V
T
G
-
G
-
E
L
F
E
D
I
V
A
-
R
------------------------------------------------------------------------------
E
Y
Y
S
E
A
D
A
S
H
C
-
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
--
A
---
S
KSKG-
A
-----
A
-
V
----
K
L
A
D
F
G
L
A
I
E
V
-----
Q
-
G
D
Q
Q
A
W
F
-
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
--
R
---
K
------
D
P
-
Y
-
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
------------
V
G
Y
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
Fugue
63.29
20%
-
- C1 -
-
3H4J
-
SNF1_SCHPO
B:
[27-356]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
R
--
H
---
I
G
P
-------------------------
Y
I
I
R
E
T
L
G
E
G
S
F
G
K
V
K
L
A
T
H
Y
K
T
Q
Q
K
V
A
L
K
F
I
S
R
Q
L
L
K
---
K
----
S
D
-
M
H--
M
R
V
E
R
E
I
S
Y
L
K
L
L
R
H
P
H
I
I
K
L
Y
D
V
I
--
T
T
P
-----
T
D
I
V
M
V
I
E
Y
A
G
G
-
E
-
L
F
D
Y
I
V
E
K
-----------------------------------------------------
K
R
M
T
---------------------------
E
D
E
G
R
R
F
-
F
Q
Q
I
I
C
A
I
E
Y
C
H
R
H
K
I
V
H
R
D
L
K
P
E
N
L
L
L
--
D
---
D
-----
N
-----
L
N
V
----
K
I
A
D
F
G
L
S
N
I
M
-----
T
-
D
G
N
-
F
L
K
-
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
--
N
---
G
------
K
L
-
Y
A
G
P
E
V
D
V
W
S
C
G
I
V
L
Y
V
M
L
------------
V
G
R
L
P
F
-
D
D
E
F
I
P
N
L
F
K
--
K
V
N
S
C
V
Y
V
M
P
D
F
L
S
P
G
A
Q
S
L
I
R
R
M
I
---
V
A
--------
D
P
M
Q
R
I
T------
I
Q
E
I
R
R
D
P
----
W
F
N
V
N
L
P
-
D
Y
L
R
PMEEVQGSYA
D
S
R
I
V
S
K
L
G
E
A
M
G
F
S
E
D
Y
I
V
E
A
LR
S
D
E
N
N
E
V
K
E
A
---
Y
N
L
L
H
E
N
Q
V
I
Q
E
K
L
E
H
H
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
Fugue
61.62
16%
-42
- C1 -
-
1TKI
-
TITIN_HUMAN
A:
[18-338]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
--
L
---
Y
E
K
-------------------------
Y
M
I
A
E
D
L
G
R
G
E
F
G
I
V
H
R
C
V
E
T
S
S
K
K
T
Y
M
A
K
F
V
---
K
V
K
---
G
----
T
D
-
Q
---
V
L
V
K
K
E
I
S
I
L
N
I
A
R
H
R
N
I
L
H
L
H
E
S
F
--
E
S
M
-----
E
E
L
V
M
I
F
E
F
I
S
G
-
L
D
I
F
E
R
I
N
T
S
-
A
F
E
L
N
------------------------------------------------------------------------------
E
R
E
I
V
S
Y
-
V
H
Q
V
C
E
A
L
Q
F
L
H
S
H
N
I
G
H
F
D
I
R
P
E
N
I
I
Y
--
Q
---
T
RRS--
S
-----
T
-
I
----
K
I
I
E
F
G
Q
A
R
Q
L
-----
K
-
P
G
D
-
N
F
R
-
L
L
F
T
A
P
E
Y
Y
A
P
E
V
H
--
Q
---
H
------
D
V
-
V
-
S
T
A
T
D
M
W
S
L
G
T
L
V
Y
V
L
L
------------
S
G
I
N
P
F
L
A
E
T
N
Q
Q
I
I
E
N
I
M
N
A
E
Y
T
F
D
E
E
A
F
K
E
I
S
I
E
A
M
D
F
V
D
R
L
LVK
E
R
--------
K
S
R
M
T
A
-------
S
E
A
L
Q
H
P
W
-----
L
K
Q
K
I
E
-
R
V
S
T
----------
K
V
I
R
T
L
K
H
R
R
Y
Y
H
T
L
I
K
K
D
L
N
M
--
V
V
S
A
A
R
I
S
C
G
---
G
A
I
R
S
Q
K
G
V
S
V
A
K
V
K
V
A
S
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
Fugue
61.13
23%
-25
- C1 -
-
4DN5
7
M3K14_HUMAN
A:
[8-351]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
E
E
Y
L
V
H
A
L
Q
G
S
V
S
S
G
Q
A
H
S
L
T
S
L
A
K
T
W
A
A
R
G
S
R
S
R
E
P
--
S
---
P
K
T
E
D
N
E
G
V
L
LTEK
L
K
P
V
DY
E
Y
R
E
EVH
W
A
T
H
Q
L
R
L
G
R
G
S
F
G
E
V
H
R
M
E
D
K
Q
T
G
F
Q
C
A
V
K
K
V
R
L
E
V
F
R
------------------
A
E
E
L
M
A
C
A
G
L
T
S
P
R
I
V
P
L
Y
G
A
V
--
R
E
G
-----
P
W
V
N
I
F
M
E
L
L
E
G
-
G
-
S
L
G
Q
L
V
K
E
-
Q
G
C
L
P
------------------------------------------------------------------------------
E
D
R
A
L
Y
Y
-
L
G
Q
A
L
E
G
L
E
Y
L
H
S
R
R
I
L
H
G
D
V
K
A
D
N
V
L
L
--
S
---
S
DG---
S
-----
H
-
A
----
A
L
C
D
F
G
H
A
V
C
L
---------------
Q
I
P
G
T
E
T
H
M
A
P
E
V
V
--
L
---
G
------
R
S
-
C
-
D
A
K
V
D
V
W
S
S
C
C
M
M
L
H
M
L
------------
N
G
C
H
P
W
T
Q
F
F
R
G
P
L
C
L
K
I
A
S
E
P
P
P
V
R
E
I
P
P
S
C
A
P
L
T
A
Q
A
I
Q
E
G
L
---
R
K
--------
E
P
I
H
R
V
S------
A
A
E
L
G
G
K
V
----
N
R
A
L
Q
Q
V
-
G
G
L
K
----------
S
P
W
R
G
E
Y
K
E
P
R
H
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
59.84
27%
-102
- C1 -
-
4BGQ
2
CDKL5_HUMAN
A:
[11-211]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
N
K
-------------------------
F
E
I
L
G
V
V
G
E
G
A
Y
G
V
V
L
K
C
R
H
K
E
T
H
E
I
V
A
I
K
K
F
K
--------------
V
-
K
---
E
T
T
L
R
E
L
K
M
L
R
T
L
K
Q
E
N
I
V
E
L
K
E
A
F
--
R
R
R
-----
G
K
L
Y
L
V
F
E
Y
V
E
K
-
N
-
M
L
E
L
L
E
E
M
-
P
------------------------------------------------------------------------------
N
G
V
P
P
E
K
V
K
S
Y
-
I
Y
Q
L
I
K
A
I
H
W
C
H
K
N
D
I
V
H
R
D
I
K
P
E
N
L
L
I
--
S
H--
N
-----
D
-----
V
-
L
----
K
L
C
D
F
G
F
A
R
N
L
-----
S
-
E
-----------
T
R
W
Y
R
S
P
E
L
L
--
L
---
G
------
A
P
-
Y
-
G
K
S
V
D
M
W
S
V
G
C
I
L
G
E
L
S
------------
D
G
Q
P
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
59.11
27%
-14
- C1 -
-
3EB0
3
?
A:
[7-329]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
-------------------------
Y
S
L
G
K
T
L
G
T
G
-
F
G
I
V
C
E
V
F
D
I
E
S
G
K
R
F
A
L
K
K
V
---------
L
----
Q
D
-
P
---
R
Y
K
N
R
E
L
D
I
M
K
V
L
D
H
V
N
I
I
-----
K
--
L
V
D
-----
Y
F
Y
T
T
-----------------------------------------------------------N
K
Y
L
N
V
I
M
E
Y
V
P
D
T
L
H
K
V
L
K
S
F
I
R
S
-------
G
R
S
I
-------
P
M
N
L
I
S
I
Y
I
Y
Q
L
F
R
A
V
G
F
I
H
S
L
G
I
C
H
R
D
I
K
P
Q
N
L
L
V
N
S
K
---
D
-----
N
-----
T
-
L
----
K
L
C
D
F
G
S
A
K
K
L
-----
I
-
P
S
E
-
P
S
V
-
A
Y
I
C
S
R
F
Y
R
A
P
E
L
M
--
L
---
G
------
A
T
E
Y
-
T
P
S
I
D
L
W
S
I
G
C
V
F
G
E
L
I
---------------
L
G
K
P
L
F
S
G
E
T
S
I
D
Q
L
V
R
I
I
Q
I
M
G
----
T
P
T
K
E
Q
M
I
R
M
N
P
H
Y
-----VR
F
P
T
L
K
A
K
D
W
R
K
I
-------
L
P
E
G
T
P
S
L
----
A
I
D
L
L
E
Q
-
I
L
R
Y
----------
E
P
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
58.68
29%
-73
- C1 -
-
3N9X
4
?
B:
[24-267]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
---
P
D
N
-------------------------
Y
I
I
K
H
L
I
G
R
G
S
Y
G
Y
V
Y
L
A
Y
D
K
N
T
E
K
N
V
A
I
K
K
V
N
R
M
F
E
D
---
L
----
I
D
-
C
---
K
R
I
L
R
E
I
T
I
L
N
R
L
K
S
D
Y
I
I
R
L
Y
D
L
I
--
I
P
D
DLLKF
D
E
L
Y
I
V
L
E
I
A
D
S
-
D
--
L
K
K
L
F
K
T
-
P
------------------------------------------------------------------------------
I
F
L
T
E
E
H
I
K
T
I
-
L
Y
N
L
L
L
G
E
N
F
I
H
E
S
G
I
I
H
R
D
L
K
P
A
N
C
L
L
--
N
---
Q
D----
C
-----
S
-
V
----
K
V
C
D
F
G
L
A
R
T
I
-----
N
---------
S
H
V
V
T
R
W
Y
R
A
P
E
L
I
--
L
L--
Q
------
E
N
-
Y
-
T
K
S
I
D
I
W
S
T
G
C
I
F
A
E
L
L
------------
N
M
L
Q
S
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
57.14
26%
-15
- C1 -
-
3HKO
2
?
A:
[25-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
K
-------------------------
Y
H
L
K
G
A
I
G
Q
G
S
Y
G
V
V
R
V
A
I
E
N
Q
T
R
A
I
R
A
I
K
--
I
M
N
K
N
K
---
I
----
R
Q
--KD
V
E
R
I
K
T
E
V
R
L
M
K
K
L
H
H
P
N
I
A
R
L
Y
E
V
Y
--
E
D
E
-----
Q
Y
I
C
L
V
M
E
L
C
H
G
-----
G
H
L
L
D
K
L
N
V
F
I
--------------------------
D
D
S
T
G
K
C
A
M
D
----------
V
V
K
T
Q
I
C
P
C
P
E
C
N
E
E
A
I
N
G
S
I--
F
R
E
S
L
D
F
V
Q
R
E
K
L
I
S
N
I
-
M
R
Q
I
F
S
A
L
H
Y
L
H
N
Q
G
I
C
H
R
D
I
K
P
E
N
F
L
F
--
S
---
T
-----
N
-----
K
-
S
F
E
I
-
K
L
V
D
F
G
L
S
K
E
F
YKLNN
G
-----------
A
G
T
P
Y
F
V
A
P
E
V
L
N
T
T
---
N
------
E
S
-
Y
-
G
P
K
C
D
A
W
S
A
G
V
L
L
H
L
L
L
------------------
M
G
A
V
P
F
P
G
V
N
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
56.41
30%
-51
- C1 -
-
3C0I
1
CSKP_HUMAN
A:
[22-231]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
---
E
D
V
-------------------------
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
SP
G
----
L
S
-
T
---
E
D
L
K
R
E
A
S
I
C
H
M
L
K
H
P
H
I
V
E
L
L
E
T
Y
--
S
S
D
-----
G
M
L
Y
M
V
F
E
F
M
D
G
-
A
-
D
L
C
F
E
I
V
K
-
R
A
D
----------------------------------------------------------
A
----------------
G
F
V
Y
S
E
A
V
A
S
H
Y
-
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
--
A
---
S
KENS-
A
-----
P
-
V
----
K
L
G
G
F
G
V
A
I
Q
L
-----
G
-
E
S
G
L
V
A
G
-
G
R
V
G
T
P
H
F
M
A
P
E
V
V
--
K
---
R
------
E
P
-
Y
-
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
------------
S
G
C
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
55.01
28%
-105
- C1 -
-
5J5T
1
M4K3_HUMAN
A:
[4-204]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
-------------------------
F
E
L
I
Q
R
I
G
S
G
T
Y
G
D
V
Y
K
A
R
N
V
N
T
G
E
L
A
A
I
K
V
I
K
L
E
P
G
---------
E
D
-
F
---
A
V
V
Q
Q
E
I
I
M
M
K
D
C
K
H
P
N
I
V
A
Y
F
G
S
Y
--
L
R
R
-----
D
K
L
W
I
C
M
E
F
C
G
G
-
G
-
S
L
Q
D
I
Y
H
V
-
T
------------------------------------------------------------------------------
G
P
L
S
E
L
Q
I
A
Y
V
-
S
R
E
T
L
Q
G
L
Y
Y
L
H
S
K
G
K
M
H
R
D
I
K
G
A
N
I
L
L
--
T
---
D
N----
G
-----
H
-
V
----
K
L
A
D
F
G
V
S
A
Q
I
-----
T
-
A
T
I
A----
A
F
I
G
T
P
Y
W
M
A
P
E
V
A
--
A
V
ER
K
------
G
G
-
Y
-
N
Q
L
C
D
L
W
A
V
G
I
T
A
I
E
L
A
------------
E
L
Q
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
Fugue
54.76
18%
11
- C1 -
-
4EUT
1
TBK1_HUMAN
A:
[2-387]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
Q
S
T
S
---
N
H
L
-------------------------
W
L
L
S
D
I
L
G
Q
G
A
T
A
N
V
F
R
G
R
H
K
K
T
G
D
L
F
A
I
K
V
F
-
N
N
I
S
F
---
L
----
R
P
-
V
---
D
V
Q
M
R
E
F
E
V
L
K
K
L
N
H
K
N
I
V
K
L
F
A
I
E
E
E
T
T
T
-----
R
H
K
V
L
I
M
E
F
C
P
C
-
G
-
S
L
Y
T
V
L
E
E
-
P
S
N
A
Y
G
L
---------------------------------------------------------------------------
P
E
S
E
F
L
I
V
-
L
R
D
V
V
G
G
M
N
H
L
R
E
N
G
I
V
H
R
N
I
K
P
G
N
I
M
R
--
V
---
I
-----
G
EDG
Q
S
V
-
Y
----
K
L
T
D
F
G
A
A
R
E
L
-----
E
-
D
D
E
-
Q
F
V
-
S
L
Y
G
T
E
E
Y
L
H
P
D
M
Y
--
E
---
R
A
VLD
H
Q
K
K
-
Y
-
G
A
T
V
D
L
W
S
I
G
V
T
F
Y
H
A
A
TGSLPFRPFEGP
R
R
N
K
E
V
M
Y
K
I
I
T
G
K
P
S
G
A
I
S
G
V
Q
K
A
E
N
G
P
I
D
W
S
G
D
M
P
V
S
--
C
S
L
---
S
R
--------
G
L
Q
V
L
L
-------
T
P
V
L
A
N
I
L
----
E
A
D
Q
E
K
C
W
G
F
D
Q
----------
F
F
A
E
T
S
D
I
L
H
R
M
V
I
H
V
F
S
L
Q
Q
M
--
T
A
H
K
I
Y
I
H
S
Y
NT
A
T
I
F
H
E
L
V
Y
K
Q
T
K
I
I
S
S
N
Q
E
L
I
Y
E
G
R
R
L
V
L
E
P
G
R
L
AQHFP
K
T
T
E
E
N
P
I
F
V
V
S
R
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
53.27
30%
-44
- C1 -
-
3C0G
1
CSKP_HUMAN
B:
[22-231]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
---
E
D
V
-------------------------
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
SP
G
----
L
S
-
T
---
E
D
L
K
R
E
A
S
I
C
H
M
L
K
H
P
H
I
V
E
L
L
E
T
Y
--
S
S
D
-----
G
M
L
Y
M
V
F
E
F
M
D
G
-
A
-
D
L
C
F
E
I
V
K
-
R
A
D
----------------------------------------------------------
A
----------------
G
F
V
Y
S
E
A
V
A
S
H
Y
-
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
--
A
---
S
KENS-
A
-----
P
-
V
----
K
L
G
G
F
G
V
A
I
Q
L
-----
G
-
E
S
G
L
V
A
G
-
G
R
V
G
T
P
H
F
M
A
P
E
V
V
--
K
---
R
------
E
P
-
Y
-
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
------------
S
G
C
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
51.31
26%
-100
* C1 *
-
4XBR
1
INKA1_HUMAN
A:
[93-288]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
Y
-------------------------
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
Q
---------
Q
R
-
R
---
E
L
L
F
N
E
V
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
--
L
V
G
-----
D
E
L
W
V
V
M
E
F
L
E
G
-
G
-
A
L
T
D
I
V
T
H
-
T
-------------------------------------------------------------------------------
R
M
N
E
E
Q
I
A
A
V
-
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
--
T
H--
D
-----
G
-----
R
-
V
----
K
L
S
D
F
G
F
C
A
Q
V
-----
S
-
K
E
V
P
R
R
K
-
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
--
S
---
R
------
L
P
-
Y
-
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
------------
D
G
E
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
Fugue
50.60
15%
-28
- C1 -
-
1KOB
1
?
A:
[23-374]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
N
D
Y
D
K
F
Y
E
D
I
W
K
K
Y
V
P
Q
P
V
E
V
K
Q
G
S
--
V
---
Y
D
Y
-------------------------
Y
D
I
L
E
E
L
G
S
G
A
F
G
V
V
H
R
C
V
E
K
A
T
G
R
V
F
V
A
K
F
I
N
T
P
--
Y
---
P
----
L
D
-
K
---
Y
T
V
K
N
E
I
S
I
M
N
Q
L
H
H
P
K
L
I
N
L
H
D
A
F
--
E
D
K
-----
Y
E
M
V
L
I
L
E
F
L
S
G
-
G
E
L
F
D
R
I
A
A
E
-
D
Y
K
M
S
------------------------------------------------------------------------------
E
A
E
V
I
N
Y
-
M
R
Q
A
C
E
G
L
K
H
M
H
E
H
S
I
V
H
L
D
I
K
P
E
N
I
M
C
--
E
---
T
KKA--
S
-----
S
-
V
----
K
I
I
D
F
G
L
A
T
K
L
-----
N
-
P
D
E
-
I
V
K
-
V
T
T
A
T
A
E
F
A
A
P
E
I
V
--
D
---
R
------
E
P
-
V
-
G
F
Y
T
D
M
W
A
I
G
V
L
G
Y
V
L
L
------------
S
G
L
S
P
F
A
G
E
D
D
L
E
T
L
Q
N
V
K
R
C
D
W
E
F
D
E
D
A
F
S
S
V
S
P
E
A
K
D
F
I
K
N
L
---
L
Q
--------
K
E
P
R
K
R
-------
L
T
V
H
D
A
L
E
----
H
P
W
L
K
G
D
-
H
S
N
L
----------
T
S
R
I
P
S
S
R
Y
N
K
I
R
Q
K
I
K
E
K
Y
A
D
--
W
P
A
P
Q
P
A
I
G
R
---
I
A
N
F
S
S
L
R
K
H
R
P
Q
E
Y
Q
I
Y
D
S
Y
F
D
R
K
E
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
HHSearch
48.80
27%
-95
- C1 -
-
5IU2
1
M3K8_HUMAN
B:
[72-262]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Y
R
-------------------------
N
-
G
S
D
F
I
P
R
G
A
F
G
K
V
Y
L
A
Q
D
I
K
T
K
K
R
M
A
C
K
L
I
P
V
D
Q
------------------
F
K
P
S
D
V
E
I
Q
A
C
F
R
H
E
N
I
A
E
L
Y
G
A
V
--
L
W
G
-----
E
T
V
H
L
F
M
E
A
G
E
G
-
G
-
S
V
L
E
K
L
E
S
-
C
------------------------------------------------------------------------------
G
P
M
R
E
F
E
I
I
W
V
-
T
K
H
V
L
K
G
L
D
F
L
H
S
K
K
V
I
H
H
D
I
K
P
S
N
I
V
F
--
M
---
S
-----
T
-----
K
-
A
----
V
L
V
D
F
G
L
S
V
Q
M
-----
T
-
E
D
V
Y
F
P
K
-
D
L
R
G
T
E
I
Y
M
S
P
E
V
I
--
L
---
C
------
R
G
-
H
-
S
T
K
A
D
I
Y
S
L
G
A
T
L
I
H
M
Q
------------
T
G
T
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
48.71
27%
-29
- C1 -
-
2X0G
-
DAPK1_HUMAN
A:
[9-215]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
---
D
D
Y
-------------------------
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
---
S
SRRG
V
S
-
R
---
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
--
E
N
K
-----
T
D
V
I
L
I
L
E
L
V
A
G
-
G
-
E
L
F
D
F
L
A
E
-
K
------------------------------------------------------------------------------
E
S
L
T
E
E
E
A
T
E
F
-
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
---
D
RNVP
K
P
-----
R
-
I
----
K
I
I
D
F
G
L
A
H
K
I
-----
D
-
F
G
N
-
E
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
V
--
N
---
Y
------
E
P
-
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
------------
S
G
A
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
48.71
24%
-106
- C1 -
-
2X4F
4
MYLK4_HUMAN
A:
[89-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
-------------------------
V
S
K
T
E
I
L
G
-----
Q
V
H
K
C
E
E
T
A
T
G
L
K
L
A
A
K
I
I
K
T
R
G
M
---------
K
D
-
K
---
E
E
V
K
N
E
I
S
V
M
N
Q
L
D
H
A
N
L
I
Q
L
Y
D
A
F
--
E
S
K
-----
N
D
I
V
L
V
M
E
Y
V
D
G
-
G
-
E
L
F
D
R
I
I
D
-
E
S
-----------------------------------------------------------------------------
Y
N
L
T
E
L
D
T
I
L
F
-
M
K
Q
I
C
E
G
I
R
H
M
H
Q
M
Y
I
L
H
L
D
L
K
P
E
N
I
L
C
--
V
NRD
A
-----
K
-----
Q
-
I
----
K
I
I
D
F
G
L
A
R
R
Y
-----
K
-
P
R
E
-
K
L
K
-
V
N
F
G
T
P
E
F
L
A
P
E
V
V
--
N
---
Y
------
D
F
-
V
-
S
F
P
T
D
M
W
S
V
G
V
I
A
Y
M
L
L
------------
S
G
L
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
22.10
42%
-73
- C1 -
-
3NAX
1
PDPK1_HUMAN
A:
[137-226]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
V
S
A
L
E
Y
L
H
G
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
--
N
---
E
-----
D
-----
M
H
I
----
Q
I
T
D
F
G
T
A
K
V
L
-----
S
P
E
S
K
-
Q
A
R
A------
Q
Y
V
S
P
E
L
L
--
T
---
E
------
K
S
-
A
-
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
------------
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
18.72
42%
-74
- C1 -
-
3Q5I
1
?
A:
[147-239]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
A
N
I
-
M
K
Q
I
L
S
G
I
C
Y
L
H
K
H
N
I
V
H
R
D
I
K
P
E
N
I
L
L
--
E
---
N
-----
K
-----
N
-
S
LL
N
I
K
I
V
D
F
G
L
S
S
F
F
-----
S
-
K
D
Y
-
K
L
R
-
D
R
L
G
T
A
Y
Y
I
A
P
E
-
V
--
L
---
K
------
K
K
-
Y
-
N
E
K
C
D
V
W
S
C
G
V
I
M
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------