@TOME V2.3
(Mar 2018)
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Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
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Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
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3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
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Structural Clustering:
Cluster Num
3D-Jury Struct. Score
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Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
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Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
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Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
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Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_20_1140: (2018-03-09 )
MQQMHWTAARGQLSGPQHSQHPSPQASSTHASQKQQQQQHLHQNGPPGLAAAGMGGGSAGVNISSGPAAGASAVRANVNSNAFHSPRFSHPMGPLPPAQNPQQQVFSVSQQPPGAQLQQQQRSPRSLSGPTPNNVVSGNRSGLETSAALAGREAPAISGANSAAAHTSSAAVGVFLSGTRTNFTDFGAAAAYGLGAGGVGSPSGPTANAGSILADANDEEVNQLLRELEFSVDSPHALAVLRDAVDAIEARALANFDPLSRDTFLEQRIRDVLTELSRTSNERSLLLAVSLIEALIPIAYTSPHSKYTRLCRSLSVLRQSGNEKAAREAQRVYKLLLEADARYPGPESPLKAFVQKELRENCEQALLQLHGRVQQAKAAFPAQFFSVMLGCAATAEVNPRYISGKTRAQAIQLGTMLTGSPDPLLRKAAYECLVAIFRNTSNMRPNELVLESRRLCDECMRTLNASQHNEGHVVSALKALHALLSSRGLSAIDRQVIPQLCVLVTEQHRVSKSLLVRSAVCDLVPIIAPVDIASMPRRTTYCAIIMEPVKNVRDERFKAHELHNVASFVRSVGYRVLDATNRTNLESILHRYISRPETQEACWSIMAAICASSASASGGAASVAPMGGRRVDYVSTSTTLPSPTTQNTHQDLSLTPSMVEGRKASQHSSRENLATSPSALQRHFSYHHGDDNDDQVSVPLVSVRTTSQRSAGTCSLSASPTSTNAPAFNLSTFSVHHTVTIDDVVLRCLPYLAHAILTQSLVDSLRVIQASCPQLRADVQMALDKLVDSVLKEPFAPSATAAAVTLPQYFSQLPSSTAQQQQQAHSLHSRDGGDGSAGGFSSAAMNSASRTAGSHPLSPASGPEPVMTLSRPGTCSTPIGVGAVGRLTQYFRPSESAAIHRGEGSTSSPTPTSPVGMRNTSGPLPSGNNSFLGPDSAYTVGGGDSNSGAPYGAGGPLRCSPLSTSMSAPFSPVTHMAAGGSGAGGGNAAAAPPSVLKNDLTVALKVFTERPLTSVQHLHDLKNSVIAFQRHEDPLVRQQSSETIISSLRQWIAYAKEHKTSTYSTRVTEILEAYMKNVLMEVDRQCGLYEITLLANATNLRAFLSEQRILSSLLSFLNSTALVREKTVELLVAITQDSKPSPSVVAVQQSLYVTVESCVVVLEYTNDVSMLLRSMADLQTFTRLCIRQLNNHLSRIFYAFRKRLLEVSVPDVVLLSILKTLEIILQALAKDEKTILQYQDDVLELYDPVVEILKQSPSPTLSHAAINVLVYVHEMCIPSASTDLRKQQELITALTHVYTSSTCTVNESLSMLTLFGQLGAIDPSAQSVATTAKKKEEAVIQDEADLELTYDYTVIVYRTLSRMLDASLSDAVCSQALRTLLQFIRFTQDKKDLVGGVHAVRAVLQITKRVTDSPALRVEALHVLAAVTAMRHERIVRLMLPEIVVLLEQLWTPKDRLLFRAVLEVVSALKPGKLSGKEQSESWAWLYPRLVDVALQDRTESREFCLRVVEIVLNASYIPPHCIPVVFPMLLQFLQQSDQLVDVRSQSLCAAVHIVCELKAVQFFSSLLHGICTLTRHCELNEDLGPRISTPGVRESLKVLAALHPSGRSTIKMLRDRIGEGDERMTNPTGSSIFNTMGLPATSVTSLAGGGSTSSMLVMGPATGNASGGQGGGLGVENPANSGIGPLVNIGGFGASTAGGGAAAAGGAAGGGSYLRLTNVSETFAGAEEEDVGLTLSADTAGQEVDLFMKHVELGFRLKENKLREWFAEFQKYIILISPHPAFRMMVDLLDKHEPLRRGLFLPSFKCLYESLSADQIKKLNEMLTLVLNCSDHELSSKCLGLADYLDHNEPNVKPEVLEVVRSMRRVDYHRVSHPSENGSLLLRSTESSTNNVVSLRTRSSASAGLPKAEFSTSSDAPIDVLPMAKVRGRKAPVFQRSSNSSAGVAGDESGTAGAEASSGASTALASPKNSANGRRSASRRDVEMYEFTSFDGNENGATESGRQQSQPIALPTSETPAQEEEAERRSCSPVDTLDGAESENKAEDVVAPVSTDHPSVGVLGAAGVHVMGSYRPLVNSVVRRCDSNAPQQSGVTSQFHIISTASTHSNDLSSDSRDGDLPPAGAHIPAQPNMLFSTEDIVRAAERTRMYDKALSYLENRLLAMLNLYRYTKMPREVIHKTVWPLAWLYSQREMQDSVVGLFRAIRYEGGEDQAGFGYELLCWWSKAQNTYAKSITQQAMRDMTVPPHILEGYVRTLTLCGEWSRAYDVAMQVCSRPEAYVSSTVARCGATAAWLLGRWDDVQHLAERLSMSEQHTTALRLFFLNGVALKSAITEHSSAAYENLRHMITQSKLVIDESLRTLLPLSYTHAYESLTMLQHFTEMEETIDYCHCRSTKGRQQIYERWNNRFRSLNPDSLQPSLLSLMLHSLVLSTGEMADMILHFCETRQSSHPQLAEWAMSWLRHGSFSGRSSNLCSPSAASPASPGPVEGITVATLSSVDKNPKVAVGFITHLWSQGKRQAAVESMEMFLRDCGKDLEENNATCYGDAQLRLGTWKQELHADSFWERGFRDEELGHFHKAIRAVPSSYEAWHSWGLMNYRIQQRDHNLSPEDQRTFVEAAHQGFVGAICRCKDSSEALPAVMRLLQLWVIHNGVELLKETVADSISRIPIDHWVQTIPQLIGHLSSDSHDIREVIGMILRSLCEVHPQATVFPLLVVMMSDASTSGSNHNALNSNGDESNIVSGASAMSDSSNPLARKQEIVQGIIQHCPKRIFHEAEAVAKLLVDVSAIPIEKIRENLSQVAAAWNPNAEYEEDPEEVYRRLQNTLDIFHANRRHLLFTVGDIGQFVQMVMEDDRNGQREKAAGVVSQLIEEISKHVAEKLGREPQKAMEPLLHLRNLSVAVFGEYDGHCRDHYPTIASFSSKLDVIPSKKRPRRIQLNGSDGCLYTYCLKGNEDIRMDERVMQLLGMVNVLLSHTRISSSAYIHRFPVIPISSNVGLLGWVENANTINNTICNYRTNISNVRTHQESSVLRAYVGSFGNWDKLSLIQRTEILDFVMQSEHCEAVDVSRAMWHRANTAEQWLDRRTAFTVSLATMSMVGYVLGLGDRHLGNILISMSSGKIVHIDFGDSFDVGRLRHVLPETIPFRLTRMLTNAMEVFGVDGVFRASATRTQTTLHKNRDSIMALLSAFVHDPIVQYKGKMKNIMEKSRSPQDIAERIRNKLRGMEMAIDHSKVNIFNTTQDSCRRPDLLYMSTAFDDTAVRTQSLAMTPEEQVSFLIDEATRIDNYTTMYFGWGPLW
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030----.......1040.....--.1050......1060...-...1070......1080.-.....1090..-----.-...1100---.-------.------------.--.....1110.....------.1120-------..-.......1130-----.......1140......1150......1160-.......1170.-.....1180.....-.1190......1200......1210......1220......1230......1240......------1250......1260......1270......1280--........1290......1300......1310......1320.......1330......1340...----------...1350..---....1360.-..--------------...1370......1380........1390.......1400......1410-------------.........1420......1430......1440........1450......1460......1470.......1480......1490......1500......1510...----.----..1520......1530......1540------.........1550....-----..1560......1570......1580......1590......1600......1610......1620......1630......1640......1650......1660......1670......1680......1690......1700......1710......1720......1730......1740......1750......1760.....-.1770......1780......1790......1800......--1810......1820......1830......1840......1850......1860......1870......1880......1890......1900......1910......1920......1930......1940......1950......1960......1970......1980......1990......2000......2010......2020......2030......2040......2050......2060......2070......2080......2090......2100......2110....---..2120......2130......2140......2150......2160......2170......2180......2190......2200.......2210.......2220......2230......2240......2250......2260......2270......2280......2290......2300......2310......2320......2330......2340...-----------...2350......2360......2370......2380......2390.......2400......2410......2420......2430-......2440.....-.2450......2460......2470......2480.....--------.2490......2500......2510......2520......2530..-----....2540---------........2550......2560......2570......2580......2590.....-.------2600-------------.........2610-----------.......2620......2630----.......2640......2650......2660......2670......2680......2690......2700........2710......2720......2730.........2740......2750...-----...2760.......2770..-....2780--------......-2790......2800.----.....2810........2820---......2830--.......2840......2850..---....2860......2870----------.......2880..--....2890......2900......2910......2920...-...2930......2940---..-----......2950......2960......2970.--.....2980-.......2990......3000......3010......3020......3030......3040......3050......3060......3070......3080...-...3090......3100......3110......3120....-----..3130......3140......3150......3160-----.-----.......3170......3180......3190-.......-----.3200-....---...3210......3220......3230......3240......3250......3260..-....3270......3280......3290....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MQQ
M
H
W
TAARGQLSGPQHSQHPSPQASST
H
A
S
Q
K
Q
Q
Q
Q
Q
H
L
HQNGPPG
L
A
AAGMGGGSAGVNISSGPAAGA
S
A
V
R
ANVNSNAFHSPRFSHPMGPLPPAQ
N
P
Q
Q
Q
V
F
S
VSQQPP
G
A
Q
L
Q
Q
Q
QRSPRSLSGPTPNNVVSGNRSGL
E
T
S
A
A
LAGREAPAISGANSAAAHTSS
A
A
V
G
V
F
L
SGTRTNFTDFG
A
A
A
A
YGLGAGGVGSPSGPTANAG
S
I
LADA
N
D
E
E
V
N
Q
L
L
R
E
L
E
FSVDS
P
H
A
L
A
V
L
R
D
A
V
D
A
I
E
A
R
ALANFDPL
S
R
D
T
F
L
E
Q
R
I
R
D
V
L
T
E
L
S
RTSNE
R
S
L
L
L
A
V
S
L
I
E
A
L
I
PIAYTSP
H
S
K
Y
T
R
L
C
R
S
L
S
V
L
R
QSG
N
E
K
A
A
R
E
A
Q
R
V
Y
K
L
L
L
EADARYPGP
E
S
P
L
K
A
F
V
Q
K
E
L
R
E
N
C
E
Q
A
L
L
Q
L
H
G
R
V
Q
Q
A
K
AA
F
P
A
Q
F
F
S
V
M
L
GCAATAEVN
P
R
YISGKT
R
A
Q
A
I
Q
L
G
T
MLTGSP
D
P
L
L
R
K
A
A
Y
E
C
L
V
A
I
F
RNTSNMR
P
N
E
L
V
L
E
S
R
R
L
C
D
E
C
M
R
TLNASQHNE
G
H
V
V
S
A
L
K
A
L
H
A
L
L
S
SR
G
L
S
A
I
D
R
Q
V
I
P
Q
L
C
V
L
V
T
E
Q
H
R
V
S
K
S
L
L
V
R
S
A
V
C
D
L
VPIIAPV
D
I
ASMPRR
T
T
Y
C
A
I
I
M
E
P
V
K
N
V
R
D
E
R
F
K
A
H
E
L
H
N
V
A
S
F
V
R
S
V
G
Y
R
VLDATNRT
N
L
E
S
I
L
H
R
YISRP
E
T
Q
E
A
C
W
S
I
M
A
A
I
CASSASASGGAASVAPMGG
R
R
V
D
Y
V
STSTTLPSPTTQNTHQDLSL
T
P
S
M
VEGRKASQHSSRENLAT
S
P
S
A
L
Q
R
H
F
SYHHGDDNDD
Q
V
S
V
P
L
V
S
V
R
TTSQRSA
G
T
C
S
LSASPTSTNAP
A
F
N
L
S
T
F
S
V
H
H
T
V
T
I
D
D
V
V
L
R
C
L
P
Y
L
A
H
A
I
L
T
Q
S
L
V
D
S
L
R
V
I
Q
AS
C
P
Q
L
R
A
D
V
Q
M
A
L
D
K
L
V
D
S
V
L
KEPFAPSAT
A
A
A
V
T
L
P
Q
Y
F
S
QLP
S
S
T
A
Q
Q
Q
Q
Q
A
H
S
LHSRDGGDGSAGGF
S
S
A
A
MNSASRTAGSHPLSPASGPEP
V
M
TLSRPGTCSTPIG
V
G
A
V
G
R
L
T
Q
Y
FRPSES
A
A
I
HRGEGSTSSPTPTSPVGMRNTSGPLPSGNNSFLGPDS
A
Y
TVGGGDSNSGAPYGAGGP
L
R
CSPLSTSMSAPFSPVTHMAAGGSGAGGGNAAAA
P
P
S
V
L
KN
D
L
T
V
A
L
K
V
FTERP
L
T
S
V
Q
H
L
H
D
L
K
N
S
V
I
A
F
QRHE-----D
P
L
V
RQQS
S
E
T
I
I
S
S
L
--
R
Q
W
I
A
Y
A
K
EHKTST
Y
S
T
R
-
V
T
E
I
L
E
A
Y
M
K
N
V
L
M
E
V
D
R-QCG
L
Y
E
I
T
L
L
A-----N-
A
T
N
L
R
-----
A
-------
F
------------
L
--
S
E
Q
R
I
L
S
S
L
L
S
F
L
N
------
S
T
----------
A
L
-
V
R
E
K
T
V
E
L
L
V
------
A
ITQDSKPSP
S
V
V
A
V
Q
Q
S
L
Y
V
T
V
E
S
C
V
V
V
L
--EYTN
D
V
S
M
L
L
R
S
-
M
A
D
L
Q
T
F
T
R
L
C
I
R
Q
-
L
N
N
H
L
S
R
I
F
Y
A
F
R
K
R
L
L
EVSV
P
D
V
V
L
L
S
I
L
K
T
L
E
I
I
L
Q
A
L
AKD
E
K
T
I
L
Q
Y
Q
D
D
V
L
E
L
Y
D
P
V
------
V
E
I
L
KQSPSP
T
L
S
H
A
A
I
N
V
L
V
Y
V
H
E
MCIPSAS----
T
D
L
R
K
Q
Q
E
L
I
T
A
L
T
H
V
YTSST
C
T
VN
E
S
L
S
M
L
T
L
F
G
QLGA-IDP
S
A
Q
S
V
A
T
T
A
K
K
K
E
E
A
VIQDEA
D
L
----------
E
L
T
Y
D
Y
T
V
I
---
V
Y
R
T
L
S
R
M
L
-
D
A--------------
S
L
S
D
A
V
C
S
Q
A
L
R
T
L
L
--
Q
F
I
R
FTQ
D
K
-
K
D
L
V
G
G
V
H
A
V
R
A
V
L
Q
I
T
K
RV----------------TDSP
A
L
R
V
E
A
L
H
V
L
A
A
V
T
A
M
R
H
E
R
I
V
R
L
M
L
P
--
E
I
V
V
L
L
E
Q
LWT
P
K
D
R
L
L
F
R
A
V
L
E
V
V
S
ALKPG-KLSGKEQSES
W
A
W
L
Y
P
R
L
V
D
V
A
L
QDRT
E
S
R
E
F
C
L
R
V
V
E
I
V
LNAS----Y----IPP
H
C
I
P
V
V
F
P
M
L
L
Q
F
L
Q
QSDQ
L
---------
V
D
V
R
S
Q
S
L
C
A
A
V
H
I
V
C
E
-----
L
K
A
V
Q
F
F
S
S
L
L
H
G
I
C
T
L
T
RHCELNEDLGPRISTP
G
V
R
E
S
L
K
V
L
A
ALHPS
G
R
S
T
I
K
M
L
R
D
RIGEGDERMTNPT
G
S
S
I
F
NTMGLPA
T
S
V
T
SLAGGGST
S
S
M
L
V
M
GPATGNASGGQGGGLGVENPANSGIGP
L
V
NIGGFGASTAGGGAAAAGGAAGGG
S
Y
L
R
L
TN
V
S
E
T
FAGAEEEDV
G
L
T
L
SADTAG
Q
E
V
D
L
F
M
K
H
V
E
L
G
F
R
L
K
E
N
K
L
R
E
W
F
A
-
E
F
Q
K
Y
I
I
L
ISP
H
P
A
F
R
M
M
V
D
L
L
DK
H
E
P
L
R
RGLFL
P
S
F
K
C
L
Y
--
E
SL
S
A
D
Q
I
K
K
L
N
E
M
L
T
L
VLNCSDH
E
L
S
S
K
C
L
G
L
A
D
Y
LDHNEPNV
K
P
E
V
L
E
V
V
R
S
M
R
R
V
D
Y
HRVSHPSENG
S
L
L
L
R
STESSTN
N
V
V
S
L
R
TRSSASAGLPKAEFSTSSDAPI
D
V
L
P
M
A
KVRGRKA
P
V
F
QRSSNSSAGVAGDESGTAGAEASSGASTALASPKNSANGRRSASRRD
V
E
M
Y
E
F
TSFDGNENGATESGRQQSQ
P
I
ALPTSETPA
Q
E
E
E
A
E
RRSCSPVDTLDGAESENKAEDVVAPVSTDHPSVGVLGAA
G
V
H
V
MGSY
R
P
L
V
N
S
V
V
R
RCDSNAPQQSGV
T
S
Q
F
H
I
I
S
TASTHSNDLSSDSRDGD---LPPAGAHIPAQPN
M
L
F
S
T
E
D
I
V
R
A
A
E
R
T
R
M
Y
D
K
A
L
S
Y
L
E
N
R
L
L
A
M
L
N
L
Y
R
Y
TKM
P
R
E
V
I
H
K
T
V
W
P
L
A
W
L
Y
S
Q
R
E
M
Q
D
S
V
V
G
L
F
R
-
A
I
RYEGGEDQ-AGFG
Y
E
L
L
C
W
WSKAQ
N
T
Y
A
K
S
I
T
Q
Q
A
M
R
DMTV
P
P
H
I
L
E
G
Y
V
R
T
L
T
L
C
GE
W
S
R
A
Y
D
V
A
M
Q
V
CSR
P
E
A
Y
V
S
S
T
V
A
R
CG
A
T
A
A
W
L
LGR
W
D
D
V
Q
H
L
A
E
R
LSM
S
E
Q
H
T
T
A
L
R
L
F
F
LN
G
V
A
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RHGSFSGRSSNLCSPSAASPASPGPVE
G
--------
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K
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FGWGPLW
56
Fugue
58.36
22%
3
- C2 -
-
5H64
-
MTOR_HUMAN
A:
[210-2549]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
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T
A
G
D
--
D
L
A
K
L
L
W
L
K
S
P
S
S
E
V
W
F
D
R
R
T
N
-
Y
T
R
S
L
A
V
M
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M
V
G
Y
I
L
G
L
G
D
R
H
P
S
N
L
M
L
D
R
L
S
G
K
I
L
H
I
D
F
G
D
-----
C
F
E
V
A
M
T
R
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K
F
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E
K
I
P
F
R
L
T
R
M
L
T
N
A
M
E
V
T
G
L
D
--
G
-----
N
-----
Y
R
I
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M
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L
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H
K
D
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V
M
A
V
L
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A
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Y
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---
P
L
L
N
W
R
L
-----
M
D
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N
--
T
A
L
N
---
K
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-
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D
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------------------------------------
L
D
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Q
A
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S
H
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N
L
C
Q
C
Y
I
G
W
C
P
F
W
57
Fugue
58.06
29%
-13
- C2 -
-
4JSP
1
MTOR_HUMAN
A:
[10-1174]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
A
A
K
C
R
A
Y
A
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A
L
H
Y
K
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------------
P
A
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N
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K
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D
K
K
M
D
T
N
-----
K
D
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L
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M
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C
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A
L
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W
G
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A
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A
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L
A
L
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L
-----------
F
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L
A
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I
-----------
D
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A
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D
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L
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A
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---
V
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--------------------
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L
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W
Q
L
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L
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I
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---
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Y
Y
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A
A
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H
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A
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A
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M
N
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-
A
V
L
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Y
K
H
Q
----------------
N
Q
A
R
D
E
K
K
K
V
T
E
------------
D
L
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K
T
L
L
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T
V
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A
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F
F
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A
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--------------------------------
T
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A
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-----
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N
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--------
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A
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M
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---
A
Y
G
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-
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---
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Y
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I
-----------
S
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-----
G
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-----
E
F
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F
L
L
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L
L
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L
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F
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-----
C
F
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L
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--
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-----
N
-----
Y
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---
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-----------------------
D
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58
Fugue
58.04
21%
0
- C2 -
-
5FVM
-
?
A:
[85-2469]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
V
K
A
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-----
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-------
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------------
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----------
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Y
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A
A
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----
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---
L
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V
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--------------
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-------------------
R
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----
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L
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R
L
G
L
A
Q
K
T
L
N
T
L
L
--------------------------------------------
E
A
P
P
P
V
V
Y
A
Q
L
K
Y
M
W
A
T
G
S
Q
K
E
A
L
N
H
L
I
S
F
T
S
R
M
A
H
D
L
GLQ
H
H
I
E
D
Y
T
K
-----------
L
L
A
R
C
F
L
K
Q
G
E
W
R
V
S
L
Q
P
N
--
W
R
L
E
N
P
D
A
I
L
G
S
Y
L
L
A
T
H
F
D
K
T
W
Y
K
A
W
H
N
W
A
L
A
N
F
E
-
V
------
T
S
S
L
T
Q
R
I
K
D
D
K
V
P
PTL
N
A
N
D
N
F
P
P
E
L
V
Q
------------
R
H
V
V
P
A
I
K
G
F
F
H
S
I
A
L
S
Q
S
S
--------
L
Q
D
T
L
R
L
L
T
L
W
F
K
F
G
G
I
P
E
A
A
Q
A
M
H
E
G
F
G
L
I
K
I
D
N
W
L
E
V
I
P
Q
L
I
S
R
I
H
Q
P
N
Q
T
V
S
R
S
L
L
S
L
L
A
D
L
G
--
K
A
H
P
Q
A
L
V
Y
P
L
T
V
A
I
K
S
D
---------------------------------
S
V
S
R
Q
R
A
-----
A
L
S
I
I
-
D
K
M
R
M
H
S
P
K
L
V
N
Q
A
-
E
L
V
S
D
E
L
I
--------
R
V
A
V
L
W
-
H
E
L
W
Y
E
G
L
E
D
A
S
R
Q
F
F
G
E-
H
N
T
E
K
M
F
--
A
T
L
E
P
L
H
E
M
L
K
R
---
G
P
E
T
L
R
E
I
S
---
F
Q
N
S
F
G
-
R
D
L
N
D
A
Y
E
W
V
L
N
Y
K
R
T
KDI
N
N
L
N
Q
A
W
D
I
Y
Y
N
V
F
R
R
I
-----------
S
R
K
L
P
Q
L
Q
T
L
D
L
Q
--
H
V
S
P
K
L
S
A
A
K
D
L
E
L
A
V
P
G
T
Y
--
H
A
G
K
P
I
V
R
I
T
H
F
E
P
V
F
T
V
I
-
S
S
K
Q
R
P
R
R
V
I
I
K
G
S
D
-----
G
K
-----
D
Y
Q
Y
L
L
K
S
H
E
D
I
R
Q
D
N
L
V
M
Q
L
F
G
L
V
N
T
L
L
Q
N
--
D
P
E
S
F
Q
R
H
L
N
I
Q
Q
Y
P
A
I
P
L
S
P
K
T
G
L
L
G
W
V
P
N
S
D
T
F
H
V
L
I
R
E
H
R
E
A
-
S
K
I
P
L
N
I
E
H
R
I
M
L
Q
M
A
P
D
Y
D
N
---
L
T
L
L
Q
K
V
E
V
F
T
Y
A
L
D
N
T
--
K
G
Q
D
L
Y
K
V
L
W
L
K
S
R
S
S
E
S
W
L
D
R
R
T
T
-
Y
T
R
S
L
A
V
M
S
M
V
G
Y
I
L
G
L
G
D
R
H
P
S
N
L
M
L
D
R
I
T
G
K
V
V
H
I
D
F
G
D
-----
C
F
E
A
A
I
L
R
E
K
Y
P
E
K
V
P
F
R
L
T
R
M
L
T
Y
A
M
E
V
S
G
I
E
--
G
-----
S
-----
F
R
I
T
C
E
N
V
M
M
V
L
R
D
N
K
E
S
L
M
A
I
L
E
A
F
A
Y
D
---
P
L
I
N
W
G
F
-----
D
L
P
T
HA
V
M
E
Q
---
T
G
I
D
L
P
L
A
N
P
S
E
L
L
R
K
G
V
I
S
V
E
D
A
A
K
M
E
L
Q
Q
K
A
E
V
R
N
A
R
A
T
L
V
L
K
R
I
A
D
K
L
T
G
N
D
F
P
R
C
Q
E
L
S
V
P
D
Q
V
D
K
L
I
Q
Q
A
T
S
V
E
N
L
C
Q
H
Y
I
G
W
C
S
--
7
PsiBlast_PDB
56.03
31%
-32
- C2 -
-
4JSX
1
B:
[509-1174]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
Q
G
F
F
R
S
I
S
L
S
R
G
N
-----
N
--
L
Q
D
T
L
R
V
L
T
L
W
F
D
Y
G
H
W
P
D
V
N
E
A
L
V
E
G
V
K
A
I
Q
I
D
T
W
L
Q
V
I
P
Q
L
I
A
R
I
D
T
P
R
P
L
V
G
R
L
I
H
Q
L
L
T
D
I
G
--
R
Y
H
P
Q
A
L
I
Y
P
L
T
V
---
A
S
K
S
T
T
T
A
R
H
N
A
A
---
N
------
K
I
L
K
N
---
M
C
E
H
S
N
T
L
V
Q
Q
A
M
M
V
S
E
E
L
I
R
V
A
I
L
W
H
---
E
M
W
H
E
G
L
E
E
A
S
R
L
Y
F
--------
G
E
R
N
V
K
G
M
F
E
V
L
E
P
L
H
A
M
M
E
R
-----
G
P
Q
T
L
K
E
--
T
S
F
N
Q
A
Y
G
R
--------
D
L
M
E
A
Q
---------------
E
W
C
R
K
Y
M
K
S
G
N
V
---
K
D
L
T
Q
A
W
D
L
Y
Y
H
V
F
R
R
I
-----------
S
K
Q
L
P
Q
L
T
S
L
E
L
Q
--
Y
V
S
P
K
L
L
M
C
R
D
L
E
L
A
V
P
G
T
Y
D
P
N
--
Q
P
I
I
R
I
Q
S
I
A
P
S
L
Q
V
I
-
T
S
K
Q
R
P
R
K
L
T
L
M
G
S
N
-----
G
H
-----
E
F
V
F
L
L
K
G
H
E
D
L
R
Q
D
E
R
V
M
Q
L
F
G
L
V
N
T
L
L
A
N
D
P
T
S
L
R
K
N
L
S
--
I
Q
R
Y
A
V
I
P
L
S
T
N
S
G
L
I
G
W
V
P
H
C
D
T
L
H
A
L
I
R
D
Y
R
E
K
K
K
I
L
L
N
I
E
H
R
I
M
L
R
M
A
----
P
D
Y
D
H
L
T
L
M
Q
K
V
E
V
F
E
H
A
V
N
N
T
A
G
D
--
D
L
A
K
L
L
W
L
K
S
P
S
S
E
V
W
F
D
R
R
T
N
-
Y
T
R
S
L
A
V
M
S
M
V
G
Y
I
L
G
L
G
D
R
H
P
S
N
L
M
L
D
R
L
S
G
K
I
L
H
I
D
F
G
D
-----
C
F
E
V
A
M
T
R
E
K
F
P
E
K
I
P
F
R
L
T
R
M
L
T
N
A
M
E
V
T
G
L
D
--
G
-----
N
-----
Y
R
I
T
C
H
T
V
M
E
V
L
R
E
H
K
D
S
V
M
A
V
L
E
A
F
V
Y
D
---
P
L
L
N
W
R
L
-----
M
D
T
N
--
T
--------------------------
A
L
N
K
K
A
I
Q
I
I
N
R
V
R
D
K
L
T
G
R
D
F
-----
S
H
D
D
T
---------
L
D
V
P
T
Q
V
E
L
L
I
K
Q
A
T
S
H
E
N
L
C
Q
C
Y
I
G
W
C
P
F
W
1
PsiBlast_PDB
55.96
31%
-32
- C2 -
-
5H64
-
MTOR_HUMAN
A:
[1884-2549]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
Q
G
F
F
R
S
I
S
L
S
R
G
N
-----
N
--
L
Q
D
T
L
R
V
L
T
L
W
F
D
Y
G
H
W
P
D
V
N
E
A
L
V
E
G
V
K
A
I
Q
I
D
T
W
L
Q
V
I
P
Q
L
I
A
R
I
D
T
P
R
P
L
V
G
R
L
I
H
Q
L
L
T
D
I
G
--
R
Y
H
P
Q
A
L
I
Y
P
L
T
V
---
A
S
K
S
T
T
T
A
R
H
N
A
A
---
N
-------------------------------
K
I
L
K
-
N
M
C
E
H
S
-
N
T
L
V
Q
Q
A
-
M
M
V
S
E
E
L
I
--------
R
V
A
I
L
W
-
H
E
M
W
H
E
G
L
E
E
A
S
R
L
Y
F
GER
N
V
K
G
M
F
E
VL
E
P
L
H
A
M
M
E
R
G
P
Q
---
T
L
K
E
T
S
F
N
Q
AYG
R
D
L
M
----
E
A
Q
E
W
C
R
K
Y
M
K
S
G
N
V
---
K
D
L
T
Q
A
W
D
L
Y
Y
H
V
F
R
R
I
-----------
S
K
Q
L
P
Q
L
T
S
L
E
L
Q
--
Y
V
S
P
K
L
L
M
C
R
D
L
E
L
A
V
P
G
T
Y
D
P
N
--
Q
P
I
I
R
I
Q
S
I
A
P
S
L
Q
V
I
-
T
S
K
Q
R
P
R
K
L
T
L
M
G
S
N
-----
G
H
-----
E
F
V
F
L
L
K
G
H
E
D
L
R
Q
D
E
R
V
M
Q
L
F
G
L
V
N
T
L
L
A
N
D
P
T
S
L
R
K
N
L
S
--
I
Q
R
Y
A
V
I
P
L
S
T
N
S
G
L
I
G
W
V
P
H
C
D
T
L
H
A
L
I
R
D
Y
R
E
K
K
K
I
L
L
N
I
E
H
R
I
M
L
R
M
A
----
P
D
Y
D
H
L
T
L
M
Q
K
V
E
V
F
E
H
A
V
N
N
T
A
G
D
--
D
L
A
K
L
L
W
L
K
S
P
S
S
E
V
W
F
D
R
R
T
N
-
Y
T
R
S
L
A
V
M
S
M
V
G
Y
I
L
G
L
G
D
R
H
P
S
N
L
M
L
D
R
L
S
G
K
I
L
H
I
D
F
G
D
-----
C
F
E
V
A
M
T
R
E
K
F
P
E
K
I
P
F
R
L
T
R
M
L
T
N
A
M
E
V
T
G
L
D
--
G
-----
N
-----
Y
R
I
T
C
H
T
V
M
E
V
L
R
E
H
K
D
S
V
M
A
V
L
E
A
F
V
Y
D
---
P
L
L
N
W
R
L
-----
M
D
T
N
--
T
--------------------------
A
L
N
K
K
A
I
Q
I
I
N
R
V
R
D
K
L
T
G
R
D
F
-----
S
H
D
D
T
---------
L
D
V
P
T
Q
V
E
L
L
I
K
Q
A
T
S
H
E
N
L
C
Q
C
Y
I
G
W
C
P
F
W
5
PsiBlast_PDB
55.71
31%
-33
- C2 -
-
4JSV
2
B:
[509-1174]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
Q
G
F
F
R
S
I
S
L
S
R
G
N
-----
N
--
L
Q
D
T
L
R
V
L
T
L
W
F
D
Y
G
H
W
P
D
V
N
E
A
L
V
E
G
V
K
A
I
Q
I
D
T
W
L
Q
V
I
P
Q
L
I
A
R
I
D
T
P
R
P
L
V
G
R
L
I
H
Q
L
L
T
D
I
G
--
R
Y
H
P
Q
A
L
I
Y
P
L
T
V
---
A
S
K
S
T
T
T
A
R
H
N
A
A
---
N
------
K
I
L
K
N
---
M
C
E
H
S
N
T
L
V
Q
Q
AMMVS
E
E
L
I
R
V
A
I
L
W
H
---
E
M
W
H
E
G
L
E
E
A
S
R
L
Y
F
--------
G
E
R
N
V
K
G
M
F
E
V
L
E
P
L
H
A
M
M
E
R
-----
G
P
Q
T
L
K
E
--
T
S
F
N
Q
A
Y
G
R
--------
D
L
M
E
A
Q
---------------
E
W
C
R
K
Y
M
K
S
G
N
V
---
K
D
L
T
Q
A
W
D
L
Y
Y
H
V
F
R
R
I
-----------
S
K
Q
L
P
Q
L
T
S
L
E
L
Q
--
Y
V
S
P
K
L
L
M
C
R
D
L
E
L
A
V
P
G
T
Y
D
P
N
--
Q
P
I
I
R
I
Q
S
I
A
P
S
L
Q
V
I
-
T
S
K
Q
R
P
R
K
L
T
L
M
G
S
N
-----
G
H
-----
E
F
V
F
L
L
K
G
H
E
D
L
R
Q
D
E
R
V
M
Q
L
F
G
L
V
N
T
L
L
A
N
DP
T
S
L
R
K
N
L
S
--
I
Q
R
Y
A
V
I
P
L
S
T
N
S
G
L
I
G
W
V
P
H
C
D
T
L
H
A
L
I
R
D
Y
R
E
K
K
K
I
L
L
N
I
E
H
R
I
M
L
R
M
A
----
P
D
Y
D
H
L
T
L
M
Q
K
V
E
V
F
E
H
A
V
N
N
T
A
G
D
--
D
L
A
K
L
L
W
L
K
S
P
S
S
E
V
W
F
D
R
R
T
N
-
Y
T
R
S
L
A
V
M
S
M
V
G
Y
I
L
G
L
G
D
R
H
P
S
N
L
M
L
D
R
L
S
G
K
I
L
H
I
D
F
G
D
-----
C
F
E
V
A
M
T
R
E
K
F
P
E
K
I
P
F
R
L
T
R
M
L
T
N
A
M
E
V
T
G
L
D
--
G
-----
N
-----
Y
R
I
T
C
H
T
V
M
E
V
L
R
E
H
K
D
S
V
M
A
V
L
E
A
F
V
Y
D
---
P
L
L
N
W
R
L
-----
M
D
T
N
--
T
--------------------------
A
L
N
K
K
A
I
Q
I
I
N
R
V
R
D
K
L
T
G
R
D
F
-----
S
H
D
D
T
---------
L
D
V
P
T
Q
V
E
L
L
I
K
Q
A
T
S
H
E
N
L
C
Q
C
Y
I
G
W
C
P
F
W
4
PsiBlast_PDB
55.57
31%
-33
- C2 -
-
4JSP
1
B:
[509-1174]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
Q
G
F
F
R
S
I
S
L
S
R
G
N
-----
N
--
L
Q
D
T
L
R
V
L
T
L
W
F
D
Y
G
H
W
P
D
V
N
E
A
L
V
E
G
V
K
A
I
Q
I
D
T
W
L
Q
V
I
P
Q
L
I
A
R
I
D
T
P
R
P
L
V
G
R
L
I
H
Q
L
L
T
D
I
G
--
R
Y
H
P
Q
A
L
I
Y
P
L
T
V
---
A
S
K
S
T
T
T
A
R
H
N
A
A
---
N
------
K
I
L
K
N
---
M
C
E
H
S
N
T
L
V
Q
Q
AMMVS
E
E
L
I
R
V
A
I
L
W
H
---
E
M
W
H
E
G
L
E
E
A
S
R
L
Y
F
--------
G
E
R
N
V
K
G
M
F
E
V
L
E
P
L
H
A
M
M
E
R
-----
G
P
Q
T
L
K
E
--
T
S
F
N
Q
A
Y
G
R
--------
D
L
M
E
A
Q
---------------
E
W
C
R
K
Y
M
K
S
G
N
V
---
K
D
L
T
Q
A
W
D
L
Y
Y
H
V
F
R
R
I
-----------
S
K
Q
L
P
Q
L
T
S
L
E
L
Q
--
Y
V
S
P
K
L
L
M
C
R
D
L
E
L
A
V
P
G
T
Y
D
P
N
--
Q
P
I
I
R
I
Q
S
I
A
P
S
L
Q
V
I
-
T
S
K
Q
R
P
R
K
L
T
L
M
G
S
N
-----
G
H
-----
E
F
V
F
L
L
K
G
H
E
D
L
R
Q
D
E
R
V
M
Q
L
F
G
L
V
N
T
L
L
A
N
DP
T
S
L
R
K
N
L
S
--
I
Q
R
Y
A
V
I
P
L
S
T
N
S
G
L
I
G
W
V
P
H
C
D
T
L
H
A
L
I
R
D
Y
R
E
K
K
K
I
L
L
N
I
E
H
R
I
M
L
R
M
A
----
P
D
Y
D
H
L
T
L
M
Q
K
V
E
V
F
E
H
A
V
N
N
T
A
G
D
--
D
L
A
K
L
L
W
L
K
S
P
S
S
E
V
W
F
D
R
R
T
N
-
Y
T
R
S
L
A
V
M
S
M
V
G
Y
I
L
G
L
G
D
R
H
P
S
N
L
M
L
D
R
L
S
G
K
I
L
H
I
D
F
G
D
-----
C
F
E
V
A
M
T
R
E
K
F
P
E
K
I
P
F
R
L
T
R
M
L
T
N
A
M
E
V
T
G
L
D
--
G
-----
N
-----
Y
R
I
T
C
H
T
V
M
E
V
L
R
E
H
K
D
S
V
M
A
V
L
E
A
F
V
Y
D
---
P
L
L
N
W
R
L
-----
M
D
T
N
--
T
--------------------------
A
L
N
K
K
A
I
Q
I
I
N
R
V
R
D
K
L
T
G
R
D
F
-----
S
H
D
D
T
---------
L
D
V
P
T
Q
V
E
L
L
I
K
Q
A
T
S
H
E
N
L
C
Q
C
Y
I
G
W
C
P
F
W
8
PsiBlast_PDB
55.55
31%
-30
- C2 -
-
4JT5
1
B:
[509-1174]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
Q
G
F
F
R
S
I
S
L
S
R
G
N
-----
N
--
L
Q
D
T
L
R
V
L
T
L
W
F
D
Y
G
H
W
P
D
V
N
E
A
L
V
E
G
V
K
A
I
Q
I
D
T
W
L
Q
V
I
P
Q
L
I
A
R
I
D
T
P
R
P
L
V
G
R
L
I
H
Q
L
L
T
D
I
G
--
R
Y
H
P
Q
A
L
I
Y
P
L
T
V
---
A
S
K
S
T
T
T
A
R
H
N
A
A
---
N
------
K
I
L
K
N
---
M
C
E
H
S
N
T
L
V
Q
Q
A
M
M
V
S
E
E
L
I
R
V
A
I
L
W
H
---
E
M
W
H
E
G
L
E
E
A
S
R
L
Y
F
--------
G
E
R
N
V
K
G
M
F
E
V
L
E
P
L
H
A
M
M
E
R
-----
G
P
Q
T
L
K
E
--
T
S
F
N
Q
A
Y
G
R
--------
D
L
M
E
A
Q
---------------
E
W
C
R
K
Y
M
K
S
G
N
V
---
K
D
L
T
Q
A
W
D
L
Y
Y
H
V
F
R
R
I
-----------
S
K
Q
L
P
Q
L
T
S
L
E
L
Q
--
Y
V
S
P
K
L
L
M
C
R
D
L
E
L
A
V
P
G
T
Y
D
P
N
--
Q
P
I
I
R
I
Q
S
I
A
P
S
L
Q
V
I
-
T
S
K
Q
R
P
R
K
L
T
L
M
G
S
N
-----
G
H
-----
E
F
V
F
L
L
K
G
H
E
D
L
R
Q
D
E
R
V
M
Q
L
F
G
L
V
N
T
L
L
A
N
D
P
T
S
L
R
K
N
L
S
--
I
Q
R
Y
A
V
I
P
L
S
T
N
S
G
L
I
G
W
V
P
H
C
D
T
L
H
A
L
I
R
D
Y
R
E
K
K
K
I
L
L
N
I
E
H
R
I
M
L
R
M
A
----
P
D
Y
D
H
L
T
L
M
Q
K
V
E
V
F
E
H
A
V
N
N
T
A
G
D
--
D
L
A
K
L
L
W
L
K
S
P
S
S
E
V
W
F
D
R
R
T
N
-
Y
T
R
S
L
A
V
M
S
M
V
G
Y
I
L
G
L
G
D
R
H
P
S
N
L
M
L
D
R
L
S
G
K
I
L
H
I
D
F
G
D
-----
C
F
E
V
A
M
T
R
E
K
F
P
E
K
I
P
F
R
L
T
R
M
L
T
N
A
M
E
V
T
G
L
D
--
G
-----
N
-----
Y
R
I
T
C
H
T
V
M
E
V
L
R
E
H
K
D
S
V
M
A
V
L
E
A
F
V
Y
D
---
P
L
L
N
W
R
L
-----
M
D
T
N
--
T
--------------------------
A
L
N
K
K
A
I
Q
I
I
N
R
V
R
D
K
L
T
G
R
D
F
-----
S
H
D
D
T
---------
L
D
V
P
T
Q
V
E
L
L
I
K
Q
A
T
S
H
E
N
L
C
Q
C
Y
I
G
W
C
P
F
W
9
PsiBlast_PDB
55.30
31%
-31
- C2 -
-
4JT6
1
B:
[509-1174]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
Q
G
F
F
R
S
I
S
L
S
R
G
N
-----
N
--
L
Q
D
T
L
R
V
L
T
L
W
F
D
Y
G
H
W
P
D
V
N
E
A
L
V
E
G
V
K
A
I
Q
I
D
T
W
L
Q
V
I
P
Q
L
I
A
R
I
D
T
P
R
P
L
V
G
R
L
I
H
Q
L
L
T
D
I
G
--
R
Y
H
P
Q
A
L
I
Y
P
L
T
V
---
A
S
K
S
T
T
T
A
R
H
N
A
A
---
N
------
K
I
L
K
N
---
M
C
E
H
S
N
T
L
V
Q
Q
A
M
M
V
S
E
E
L
I
R
V
A
I
L
W
H
---
E
M
W
H
E
G
L
E
E
A
S
R
L
Y
F
--------
G
E
R
N
V
K
G
M
F
E
V
L
E
P
L
H
A
M
M
E
R
-----
G
P
Q
T
L
K
E
--
T
S
F
N
Q
A
Y
G
R
--------
D
L
M
E
A
Q
---------------
E
W
C
R
K
Y
M
K
S
G
N
V
---
K
D
L
T
Q
A
W
D
L
Y
Y
H
V
F
R
R
I
-----------
S
K
Q
L
P
Q
L
T
S
L
E
L
Q
--
Y
V
S
P
K
L
L
M
C
R
D
L
E
L
A
V
P
G
T
Y
D
P
N
--
Q
P
I
I
R
I
Q
S
I
A
P
S
L
Q
V
I
-
T
S
K
Q
R
P
R
K
L
T
L
M
G
S
N
-----
G
H
-----
E
F
V
F
L
L
K
G
H
E
D
L
R
Q
D
E
R
V
M
Q
L
F
G
L
V
N
T
L
L
A
N
D
P
T
S
L
R
K
N
L
S
--
I
Q
R
Y
A
V
I
P
L
S
T
N
S
G
L
I
G
W
V
P
H
C
D
T
L
H
A
L
I
R
D
Y
R
E
K
K
K
I
L
L
N
I
E
H
R
I
M
L
R
M
A
----
P
D
Y
D
H
L
T
L
M
Q
K
V
E
V
F
E
H
A
V
N
N
T
A
G
D
--
D
L
A
K
L
L
W
L
K
S
P
S
S
E
V
W
F
D
R
R
T
N
-
Y
T
R
S
L
A
V
M
S
M
V
G
Y
I
L
G
L
G
D
R
H
P
S
N
L
M
L
D
R
L
S
G
K
I
L
H
I
D
F
G
D
-----
C
F
E
V
A
M
T
R
E
K
F
P
E
K
I
P
F
R
L
T
R
M
L
T
N
A
M
E
V
T
G
L
D
--
G
-----
N
-----
Y
R
I
T
C
H
T
V
M
E
V
L
R
E
H
K
D
S
V
M
A
V
L
E
A
F
V
Y
D
---
P
L
L
N
W
R
L
-----
M
D
T
N
--
T
--------------------------
A
L
N
K
K
A
I
Q
I
I
N
R
V
R
D
K
L
T
G
R
D
F
-----
S
H
D
D
T
---------
L
D
V
P
T
Q
V
E
L
L
I
K
Q
A
T
S
H
E
N
L
C
Q
C
Y
I
G
W
C
P
F
W
2
PsiBlast_PDB
53.96
31%
-34
- C2 -
-
3JBZ
2
A:
[500-1165]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
Q
G
F
F
R
S
I
S
L
S
R
G
N
-----
N
--
L
Q
D
T
L
R
V
L
T
L
W
F
D
Y
G
H
W
P
D
V
N
E
A
L
V
E
G
V
K
A
I
Q
I
D
T
W
L
Q
V
I
P
Q
L
I
A
R
I
D
T
P
R
P
L
V
G
R
L
I
H
Q
L
L
T
D
I
G
--
R
Y
H
P
Q
A
L
I
Y
P
L
T
V
---
A
S
K
S
T
T
T
A
R
H
N
A
A
---
N
------
K
I
L
K
N
---
M
C
E
H
S
N
T
L
V
Q
Q
A
M
M
V
S
E
E
L
I
R
V
A
---------------------------------------------------------------------------------------------------------------------------------------------------------
T
S
L
E
L
Q
--
Y
V
S
P
K
L
L
M
C
R
D
L
E
L
A
V
P
G
T
Y
D
P
N
--
Q
P
I
I
R
I
Q
S
I
A
P
S
L
Q
V
I
-
T
S
K
Q
R
P
R
K
L
T
L
M
G
S
N
-----
G
H
-----
E
F
V
F
L
L
K
G
H
E
D
L
R
Q
D
E
R
V
M
Q
L
F
G
L
V
N
T
L
L
A
N
D
P
T
S
L
R
K
N
L
S
--
I
Q
R
Y
A
V
I
P
L
S
T
N
S
G
L
I
G
W
V
P
H
C
D
T
L
H
A
L
I
R
D
Y
R
E
K
K
K
I
L
L
N
I
E
H
R
I
M
L
R
M
----
A
P
D
Y
D
H
L
T
L
M
Q
K
V
E
V
F
E
H
A
V
N
N
T
A
G
D
--
D
L
A
K
L
L
W
L
K
S
P
S
S
E
V
W
F
D
R
R
T
N
-
Y
T
R
S
L
A
V
M
S
M
V
G
Y
I
L
G
L
G
D
R
H
P
S
N
L
M
L
D
R
L
S
G
K
I
L
H
I
D
F
G
D
-----
C
F
E
V
A
M
T
R
E
K
F
P
E
K
I
P
F
R
L
T
R
M
L
T
N
A
M
E
V
T
G
L
D
--
G
-----
N
-----
Y
R
I
T
C
H
T
V
M
E
V
L
R
E
H
K
D
S
V
M
A
V
L
E
A
F
V
Y
D
---
P
L
L
N
W
R
L
-----
M
D
T
N
--
T
--------------------------
A
L
N
K
K
A
I
Q
I
I
N
R
V
R
D
K
L
T
G
R
D
F
-----
S
H
D
D
T
---------
L
D
V
P
T
Q
V
E
L
L
I
K
Q
A
T
S
H
E
N
L
C
Q
C
Y
I
G
W
C
P
F
W
42
HHSearch
48.40
26%
-147
- C2 -
-
5C46
-
PI4KB_HUMAN
E:
[285-488]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
-----
W
R
-----
L
L
S
V
I
V
K
C
G
D
D
L
R
Q
E
L
L
A
F
Q
V
L
K
Q
L
Q
S
I
W
E
Q
--
E
R
--
V
P
L
W
--
I
K
P
Y
K
I
L
V
I
S
A
D
S
G
M
I
E
P
V
V
N
A
V
S
I
H
Q
V
K
K
Q
S
Q
------------
L
S
L
L
D
Y
F
---------------------
L
Q
E
H
-------------
G
S
Y
T
T
E
A
F
L
S
A
Q
R
N
-
F
V
Q
S
C
A
G
Y
C
L
V
C
Y
L
L
Q
V
K
D
R
H
N
G
N
I
L
L
D
A
-
E
G
H
I
I
H
I
D
F
G
F
-----
I
L
S
S
S
P
--------
S
A
F
K
L
T
T
E
F
V
D
V
M
G
--
G
L
D
--
G
DMFN-
Y
-----
Y
K
M
L
M
L
Q
G
L
I
A
A
R
K
H
M
D
K
V
V
Q
I
V
E
I
M
Q
Q
G
---
S
--------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
47.72
31%
-
- C2 -
-
4JSN
-
MTOR_HUMAN
B:
[1884-2549]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
Q
G
F
F
R
S
I
S
L
S
R
G
N
-----
N
--
L
Q
D
T
L
R
V
L
T
L
W
F
D
Y
G
H
W
P
D
V
N
E
A
L
V
E
G
V
K
A
I
Q
I
D
T
W
L
Q
V
I
P
Q
L
I
A
R
I
D
T
P
R
P
L
V
G
R
L
I
H
Q
L
L
T
D
I
G
--
R
Y
H
P
Q
A
L
I
Y
P
L
T
V
---
A
S
K
S
T
T
T
A
R
H
N
A
A
---
N
------
K
I
L
K
N
---
M
C
E
H
S
N
T
L
V
Q
Q
AMMVS
E
E
L
I
R
V
A
I
L
W
H
---
E
M
W
H
E
G
L
E
E
A
S
R
L
Y
F
--------
G
E
R
N
V
K
G
M
F
E
V
L
E
P
L
H
A
M
M
E
R
-----
G
P
Q
T
L
K
E
--
T
S
F
N
Q
A
Y
G
R
--------
D
L
M
E
A
Q
---------------
E
W
C
R
K
Y
M
K
S
G
N
V
---
K
D
L
T
Q
A
W
D
L
Y
Y
H
V
F
R
R
I
-----------
S
K
Q
L
P
Q
L
T
S
L
E
L
Q
--
Y
V
S
P
K
L
L
M
C
R
D
L
E
L
A
V
P
G
T
Y
D
P
N
--
Q
P
I
I
R
I
Q
S
I
A
P
S
L
Q
V
I
-
T
S
K
Q
R
P
R
K
L
T
L
M
G
S
N
-----
G
H
-----
E
F
V
F
L
L
K
G
H
E
D
L
R
Q
D
E
R
V
M
Q
L
F
G
L
V
N
T
L
L
A
N
DP
T
S
L
R
K
N
L
S
--
I
Q
R
Y
A
V
I
P
L
S
T
N
S
G
L
I
G
W
V
P
H
C
D
T
L
H
A
L
I
R
D
Y
R
E
K
K
K
I
L
L
N
I
E
H
R
I
M
L
R
M
A
----
P
D
Y
D
H
L
T
L
M
Q
K
V
E
V
F
E
H
A
V
N
N
T
A
G
D
--
D
L
A
K
L
L
W
L
K
S
P
S
S
E
V
W
F
D
R
R
T
N
-
Y
T
R
S
L
A
V
M
S
M
V
G
Y
I
L
G
L
G
D
R
H
P
S
N
L
M
L
D
R
L
S
G
K
I
L
H
I
D
F
G
D
-----
C
F
E
V
A
M
T
R
E
K
F
P
E
K
I
P
F
R
L
T
R
M
L
T
N
A
M
E
V
T
G
L
D
--
G
-----
N
-----
Y
R
I
T
C
H
T
V
M
E
V
L
R
E
H
K
D
S
V
M
A
V
L
E
A
F
V
Y
D
---
P
L
L
N
W
R
L
-----
M
D
T
N
--
T
--------------------------
A
L
N
K
K
A
I
Q
I
I
N
R
V
R
D
K
L
T
G
R
D
F
-----
S
H
D
D
T
---------
L
D
V
P
T
Q
V
E
L
L
I
K
Q
A
T
S
H
E
N
L
C
Q
C
Y
I
G
W
C
P
F
W
59
Fugue
43.65
15%
-17
- C2 -
-
1E8X
1
PK3CG_PIG
A:
[1-951]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
S
E
E
T
L
A
F
Q
R
Q
L
N
A
L
I
GYDVTDVSNVH
D
D
E
L
E
F
T
R
R
R
L
V
T
P
R
M
A
E
V
A
G
R
D
P
K
L
Y
A
M
H
P
W
V
T
S
K
P
L
P
E
Y
L
L
K
-
K
I
T
N
N
C
V
F
I
V
I
H
R
S
T
T
S
Q
T
I
K
V
S
--
A
D
D
T
P
G
T
I
L
Q
S
F
F
T
K
M
A
N
-
E
R
D
F
V
L
R
V
C
G
R
D
E
Y
L
-
V
G
E
T
P
I
K
N
F
Q
W
V
R
Q
C
L
K
N
G
E
E
I
H
L
V
L
D
T
P
P
D
P
A
L
D
E
V
R
K
E
CD
R
K
F
R
V
K
I
R
G
I
D
I
P
V
L
P
R
T
A
D
L
T
V
F
V
E
A
N
I
Q
Y
G
Q
Q
V
L
C
Q
R
R
T
-----------------------------------------
S
P
K
P
F
T
E
E
V
L
W
N
V
W
L
E
F
S
I
K
I
K
D
L
P
K
G
A
L
L
N
L
Q
I
Y
C
Q
L
L
Y
Y
V
N
L
L
L
I
D
H
R
-
F
------
L
----------------
L
R
H
---
G
E
Y
V
L
H
------------
M
W
Q
L
S
G
F
N
A
D
K
L
T
S
A
T
N
P
D
K
-----
E
N
S
M
S
I
S
I
L
L
D
N
H
P
I
A
L
E
M
P
N
Q
L
R
K
Q
L
E
A
I
I
A
T
D
P
L
N
P
L
T
A
E
D
K
E
L
L
W
H
F
R
Y
E
S
L
K
D
P
K
A
Y
P
K
L
F
S
S
V
K
WG
Q
Q
E
I
V
A
K
T
Y
Q
L
L
A
K
R
E
V
W
D
Q
S
A
L
D
V
G
L
T
M
Q
L
L
D
C
N
F
S
D
E
N
V
R
A
I
A
V
Q
K
L
E
S
L
E
D
D
D
V
L
-----
H
Y
L
L
Q
---
L
V
Q
A
V
K
F
E
P
Y
H
D
-
S
A
L
A
R
F
L
L
--------
K
R
G
L
R
N
-
K
R
I
G
H
F
L
F
W
F
L
R
S
E
I
----
A
Q
S
R
H
Y
Q
--
Q
R
F
A
V
I
L
E
A
Y
L
R
---
G
C
G
T
A
M
L
H
D
---
F
T
Q
Q
V
Q
V
I
D
M
L
Q
K
V
T
I
D
I
K
S
L
S
A
---
E
K
Y
D
V
S
S
Q
V
I
S
Q
L
K
Q
K
L
-----------
E
N
L
Q
N
L
N
L
P
Q
S
F
R
--
V
P
Y
D
P
G
L
K
A
G
A
L
V
---------------------
I
E
K
C
K
V
M
-
A
S
K
K
K
P
L
W
L
E
F
K
C
A
D
PTALS
N
E
-----
T
I
G
I
I
F
K
H
G
D
D
L
R
Q
D
M
L
I
L
Q
I
L
R
I
M
E
S
I
W
E
T
--
E
S
L
D
--
L
C
--
L
L
P
Y
G
C
I
S
T
G
D
K
I
G
M
I
E
I
V
K
D
A
T
T
I
A
K
I
Q
Q
S
T
V
G
N
T
G
A
F
K
D
E
----------------------------------------
V
L
S
H
W
L
K
E
K
C
P
I
E
E
K
F
Q
A
A
V
E
R
-
F
V
Y
S
C
A
G
Y
C
V
A
T
F
V
L
G
I
G
D
R
H
N
D
N
I
M
I
S
-
E
T
G
N
L
F
H
I
D
F
G
-------------------
H
V
P
F
V
L
T
P
D
F
L
F
V
M
G
T
S
G
K
K
--
T
S
L
H
F
Q
K
-----
F
Q
D
V
C
V
K
A
Y
L
A
L
R
H
H
T
N
L
L
I
I
L
F
S
M
M
L
M
T
---
G
M
P
Q
L
T
S
K
E
D
I
E
Y
I
R
D
--
A
L
T
V
---
G
K
S
E
E
D
A
K
K
Y
F
L
D
Q
I
E
V
C
R
D
K
G
W
T
V
Q
F
N
W
F
L
H
L
V
L
---------------------------------------------------------
45
HHSearch
42.91
11%
-75
- C1 -
-
4FDD
-
TNPO1_HUMAN
A:
[212-765]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
D
S
F
I
E
N
L
F
A
L
A
G
D
E
-----
E
P
E
V
R
K
N
V
C
R
A
L
V
M
L
L
--
E
V
R
M
D
R
---------
L
L
P
H
M
H
N
I
V
E
Y
M
L
Q
-
R
T
Q
D
Q
D
E
-
N
V
A
L
E
A
C
E
F
W
L
-----
T
---
L
A
E
QPI
C
K
D
-------
V
------------
L
V
R
H
L
P
K
L
I
P
V
L
V
N
G
M
K
------
Y
S
D
I
D
I
I
L
L
K
GS
D
W
N
L
R
K
C
S
A
A
A
L
D
------
V
L
A
---
N
V
Y
R
D
E
L
--
L
P
H
I
L
P
----
L
L
K
E
L
--
L
F
H
H
E
W
V
V
K
E
S
G
-
I
L
V
L
G
A
I
A
E
G
C
M
Q
G
-
M
I
P
Y
L
P
E
L
I
P
H
L
I
Q
C
L
S
D
--
K
K
A
L
V
R
S
I
T
C
W
T
L
S
R
Y
A
H
W
V
V
S
Q
P
P
--
D
T
Y
---
L
K
P
L
M
T
E
L
------
L
K
R
I
L
-
D
S
N
K
R
V
Q
E
A
A
C
S
A
F
A
T
L
---
E
E
E
A
C
T
----
E
L
V
P
Y
L
A
Y
I
L
D
T
L
V
F
A
F
S
K
--
Y
Q
H
K
N
L
L
I
L
Y
D
A
I
G
T
L
A
D
-
S
V
G
H
H
L
N
K
-------------------------------
P
E
Y
I
Q
M
---
L
M
P
P
L
I
Q
K
W
N
M
L
--------------
K
D
E
D
K
D
L
F
P
L
L
E
C
L
S
--
S
V
A
T
A
L
Q
S
G
F
L
P
Y
C
E
--
P
V
Y
Q
R
C
V
N
L
V
Q
K
T
L
A
Q
A
M
L
N
N
A
QPDQYEA
P
-
D
K
D
F
M
I
V
A
L
D
L
L
S
G
L
A
E
G
L
G
G
N
-
I
E
Q
L
V
A
R
S
N
I
L
T
L
M
Y
Q
C
M
Q
D
K
M
P
E
V
R
Q
S
S
F
A
L
L
G
D
L
T
-
K
-
A
C
F
-
Q
H
V
K
P
C
I
A
D
F
M
P
I
L
G
T
N
L
N
P
E
F
I
S
V
C
---
N
N
A
T
W
A
I
G
E
I
S
I
Q
M
G
I
----
E
M
Q
P
Y
I
P
M
V
L
H
Q
L
V
E
I
I
N
R
P
N
T
P
---------
K
T
L
L
E
N
T
A
I
T
I
G
R
L
G
Y
V
CP---
Q
E
V
A
P
M
L
Q
Q
F
I
R
P
W
C
T
S
L
R
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
42.87
23%
-83
- C2 -
-
5DXU
1
PK3CD_HUMAN
A:
[771-969]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
V
-----
G
I
-----
I
F
----
K
N
G
D
D
L
R
Q
D
M
L
T
L
Q
M
I
Q
L
M
D
V
L
W
K
Q
--
E
G
L
D
L
R
----
M
T
P
Y
G
C
L
P
T
G
D
R
T
G
L
I
E
V
V
L
R
S
D
T
I
A
N
I
Q
L
N
-------------
D
A
L
L
N
---------------------------------------
W
L
K
S
K
N
P
G
E
A
L
D
R
A
I
E
E
F
T
L
S
C
A
G
Y
C
V
A
T
Y
V
L
G
I
G
D
R
H
S
D
N
I
M
I
R
-
E
S
G
Q
L
F
H
I
D
F
G
H
FLGNF------------
E
R
V
P
F
I
L
T
Y
D
F
V
H
V
I
Q
Q
G
K
T
N
--
N
-----
S
E
K
F
E
R
F
R
G
Y
C
E
R
A
Y
T
I
L
R
R
H
--------------------------------------------------------------------------------------------------------------------------------------
60
Fugue
40.20
18%
-13
* C2 *
-
4D0L
2
PI4KB_HUMAN
A:
[10-566]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
L
L
R
---
L
F
E
S
K
L
F
D
I
S
M
A
I
S
Y
L
Y
N
S
K
E
P
-
G
V
Q
-----
A
Y
I
G
N
-
R
L
F
C
F
R
N
E
D
V
D
F
Y
L
-
P
Q
L
L
N
M
Y
I
HMD
E
D
V
G
D
A
I
K
P
Y
I
-
V
H
R
C
R
Q
S
I
N
F
S
L
Q
C
A
----
L
L
L
G
A
Y
S
--
S
R
G
T
K
L
R
K
L
I
L
S
---
R
L
----
A
P
E
---
R
E
F
I
K
S
L
M
A
I
G
K
R
L
A
T
L
--
P
T
K
E
---
Q
K
T
Q
R
L
I
S
E
L
S
L
L
N
H
K
L
PARVWLPTAG
F
D
H
H
V
V
R
V
P
H
T
Q
A
V
VL
N
S
K
D
K
A
P
Y
L
I
Y
V
E
V
L
E
C
E
N
F
D
T
--
T
S
V
P
A
R
I
P
E
N
P
S
A
V
A
L
K
E
P
W
Q
E
K
V
R
R
I
R
E
G
S
P
Y
-----
G
H
LPN
W
R
L
L
S
V
I
V
K
C
G
D
D
L
R
Q
E
L
L
A
F
Q
V
L
K
Q
L
Q
S
I
W
E
Q
--
E
R
V
P
--
L
W
--
I
K
P
Y
K
I
L
V
I
S
A
D
S
G
M
I
E
P
V
V
N
A
V
S
-----------
I
H
Q
V
K
K
Q
S
Q
L
S
L
L
D
Y
F
L
Q
E
H
G
S
Y
-----------------------------------
T
T
E
A
F
L
S
A
Q
R
N
-
F
V
Q
S
C
A
G
Y
C
L
V
C
Y
L
L
Q
V
K
D
R
H
N
G
N
I
L
L
D
-
A
E
G
H
I
I
H
I
D
F
G
--------------
F
I
L
S
S
S
S
A
F
K
L
T
T
E
F
V
D
V
M
G
G
L
D
G
D
M
F
N
-----
Y
-----
Y
K
M
L
M
L
Q
G
L
I
A
A
R
K
H
M
D
K
V
V
Q
I
V
E
I
M
Q
Q
G
SQL
P
C
F
H
G
S
S
-----
T
I
R
N
--
L
K
E
R
F
HM
S
M
T
E
E
Q
L
Q
L
L
V
E
Q
M
V
D
G
S
M
R
S
-----------------------------------------------------------------------
16
PsiBlast_PDB
40.02
22%
-68
- C2 -
-
5IS5
1
PK3CD_MOUSE
A:
[778-970]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
K
N
G
D
D
L
R
Q
D
M
L
T
L
Q
M
I
Q
L
M
D
V
L
W
K
Q
--
E
G
L
D
L
R
----
M
T
P
Y
G
C
L
P
T
G
D
R
T
G
L
I
E
V
V
L
H
S
D
T
I
A
N
I
Q
L
N
--------
A
A
F
N
K
D
A
L
L
N
---------------------------------------
W
L
K
S
K
N
P
G
E
A
L
D
R
A
I
E
E
F
T
L
S
C
A
G
Y
C
V
A
T
Y
V
L
G
I
G
D
R
H
S
D
N
I
M
I
R
-
E
S
G
Q
L
F
H
I
D
F
G
H
FLGN--------------
R
V
P
F
I
L
T
Y
D
F
V
H
V
I
Q
Q
G
K
T
N
--
N
-----
S
E
K
F
E
R
F
R
G
Y
C
E
R
A
Y
T
I
L
R
R
H
--------------------------------------------------------------------------------------------------------------------------------------
49
HHSearch
39.33
10%
-50
- C1 -
-
2BPT
-
?
A:
[223-789]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
L
M
Q
V
V
C
E
A
T
Q
A
E
-----
D
I
E
V
Q
A
A
A
F
G
C
L
C
K
I
M
--
S
K
Y
Y
T
F
---------
M
K
P
Y
M
E
Q
A
L
Y
A
L
T
I
A
T
M
K
S
P
N
D
-
K
V
A
S
M
T
V
E
F
W
S
-----
T
I
C
E
E
E
I
-----
D
I
A
Y
E
L
A
Q
F
PQSPLQSYN
F
A
L
S
--
S
I
K
D
V
V
P
N
L
L
N
L
L
T
RQNEDE
D
D
----------
D
W
N
V
S
M
S
A
G
A
C
L
Q
------
L
F
A
---
Q
N
C
G
N
H
I
--
L
E
P
----
V
L
E
F
V
E
Q
N
--
I
T
A
D
N
W
R
N
R
E
A
A
-
V
M
A
F
G
S
I
M
D
G
P
D
K
V
Q
R
T
Y
Y
V
H
Q
A
L
P
S
I
L
N
L
M
N
D
--
Q
S
L
Q
V
K
E
T
T
A
W
C
I
G
R
I
A
D
-
S
V
A
E
S
I
D
P
Q
Q
H
---
L
P
G
V
V
Q
A
C
------
L
I
G
L
Q
-
D
-
H
P
K
V
A
T
N
C
S
W
T
I
I
N
L
---
V
E
Q
L
A
E
ATPS
P
I
Y
N
F
Y
P
A
L
V
D
G
L
I
G
A
A
N
R
I
D
N
E
F
N
A
R
A
S
A
F
S
A
L
T
T
M
V
E
-
Y
A
T
D
T
V
A
E
---------------------------------
T
S
A
S
---
I
S
T
F
V
M
D
K
L
G
Q
T
M
S
VDENQLT
L
E
D
A
Q
S
L
Q
-
E
L
Q
S
N
I
L
T
V
L
A
--
A
V
I
R
K
S
P
S
S
V
E
P
V
A
D
--
M
L
M
G
L
F
F
R
L
L
E
K
K
----------------
D
-
S
A
F
I
E
D
D
V
F
Y
A
I
S
A
L
A
A
S
L
G
K
G
-
F
E
K
Y
L
E
--
T
F
S
P
Y
L
L
K
A
L
N
Q
V
D
S
P
V
S
I
T
A
V
G
F
I
A
D
I
S
-
N
-
S
L
E
-
E
D
F
R
R
Y
S
D
A
M
M
N
V
L
A
Q
M
I
S
N
P
N
A
-
R
R
E
L
K
P
A
V
L
S
V
F
G
D
I
A
----
S
N
I
GA
D
F
I
P
Y
L
N
D
I
M
A
L
C
V
A
A
Q
N
T
K
P
E
N
GT
L
E
A
L
D
Y
Q
I
K
V
L
E
A
V
L
D
A
Y
V
G
I
V
A
G
L
H
DKP
E
A
L
F
P
Y
V
G
T
I
F
Q
F
I
A
Q
V
A
E
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
38.87
23%
-72
- C2 -
-
5T8F
1
PK3CD_HUMAN
A:
[756-954]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
V
-----
G
I
-----
I
F
----
K
N
G
D
D
L
R
Q
D
M
L
T
L
Q
M
I
Q
L
M
D
V
L
W
K
Q
--
E
G
L
D
L
R
----
M
T
P
Y
G
C
L
P
T
G
D
R
T
G
L
I
E
V
V
L
R
S
D
T
I
A
N
I
Q
L
N
-------------
D
A
L
L
N
---------------------------------------
W
L
K
S
K
N
P
G
E
A
L
D
R
A
I
E
E
F
T
L
S
C
A
G
Y
C
V
A
T
Y
V
L
G
I
G
D
R
H
S
D
N
I
M
I
R
-
E
S
G
Q
L
F
H
I
D
F
G
H
FLGN-------------
E
R
V
P
F
I
L
T
Y
D
F
V
H
V
I
Q
Q
G
K
T
N
--
N
-----
S
E
K
F
E
R
F
R
G
Y
C
E
R
A
Y
T
I
L
R
R
H
--------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
38.60
22%
-65
- C2 -
-
4XE0
1
PK3CD_MOUSE
A:
[673-865]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
K
N
G
D
D
L
R
Q
D
M
L
T
L
Q
M
I
Q
L
M
D
V
L
W
K
Q
--
E
G
L
D
L
R
----
M
T
P
Y
G
C
L
P
T
G
D
R
T
G
L
I
E
V
V
L
H
S
D
T
I
A
N
I
Q
L
N
-
K
S
N
M
A
A
T
A
A
F
N
K
D
A
L
L
N
---------------------------------------
W
L
K
S
K
N
P
G
E
A
L
D
R
A
I
E
E
F
T
L
S
C
A
G
Y
C
V
A
T
Y
V
L
G
I
G
D
R
H
S
D
N
I
M
I
R
-
E
S
G
Q
L
F
H
I
D
F
G
H
FLGN--------------
R
V
P
F
I
L
T
Y
D
F
V
H
V
I
Q
Q
G
K
T
N
--
N
-----
S
E
K
F
E
R
F
R
G
Y
C
E
R
A
Y
T
I
L
R
R
H
--------------------------------------------------------------------------------------------------------------------------------------