@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_20_1370: (2018-03-09 )
MSTASQHRKSDSAERDEVNVKNAPKVASEAEINRRNVVFAEALRCACIAMRVGDDPGYIWTPQRLGAGSFGTVTLAYRHEGDAVWRKTAVKRISLRKEMRLSAVLEKVRCAGREVALCRRAGVSPHVVPMYEPWFDCREGVIALPMDAGDFSLEQYAVHCGFRFPPLVLLSMCAQCARAVAHLHRRGVVHRDVKPDNFVVNVFDTAGGAGAGGDGGRRDARAPLVRILDFGLACGVEEVGQELKRCVGTPHYMAPETFSHLCDCDVPAACDVWSLGVTLFRLATGVFPVFEMDKTWQQPPFTALHSGKLWLPSRNLFHEPLSAESLAVLSVAASMLVLDPRYRPTADAAVLQLQGFQEAFSHQIQSWPPGSGPQPCRVWKRTRK
Atome Classification :
(20 SA)
.........10........20........30........40......-..50........60........70.....-.-..80........90........100.......110.......120.......130.......140.......150........160--........170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350----------------.........360......-.370.......380..----------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MST
A
S
Q
HRKSDSAERDEVNVKNAPKVA
S
E
AEINRR
N
V
V
F
A
E
A
L
R
C
A
C
-
I
A
M
R
VGDDP
G
Y
I
WT
P
Q
RLGAGS
F
G
T
V
T
L
A
-
Y
-RHEG
D
A
V
W
R
K
T
A
V
K
R
I
S
L
R
K
E
M
R
L
S
A
V
L
E
K
V
R
CAG
R
E
V
A
L
C
R
RAGVSPH
V
V
P
M
YE
P
W
F
D
CRE
G
V
I
A
L
PMDAGD-F
S
L
E
Q
Y
A
V
HCG---FRF
P
P
L
V
L
L
S
M
C
A
Q
C
A
R
A
V
A
H
L
H
RRGVVHRDVKPD
N
F
V
V
N
V
F
DTAGGAGAGGDGGRRDAR
A
P
L
V
R
I
L
D
F
G
LAC
G
V
E
E
V
G
Q
E
L
K
R
C
VGTPHYM
A
P
E
T
F
S
H
LCDCDVPAAC
D
V
W
S
L
G
V
T
L
F
R
L
A
TGV
F
P
V
FEMDKTWQQPPFTALHSG
K
L
WLPSRNLFHEPL
S
A
E
S
L
A
V
L
S
V
A
A
S
M
L
V
LDPRYRPTA
D
A
A
V
------------------
L
Q
L
Q
G
F
Q
E
A
F
S
H
Q
I
QSWP-PGSGP
Q
P
C
R
V
W
K
RTRK----------------------------------------------
49
Fugue
72.33
20%
-83
- C1 -
-
1KOB
1
?
A:
[23-374]
-------
I
N
D
Y
D
K
F
Y
E
D
I
W
K
K
Y
V
P
Q
P
V
E
V
K
Q
G
S
V
Y
D
----------------------
Y
Y
D
I
L
E
E
L
G
S
G
A
F
G
V
V
H
R
C
-
V
-
E
K
A
T
G
---
R
V
F
V
A
K
F
I
N
T
P
Y
P
L
D
K
Y
T
V
K
N
E
I
S
I
M
--------
N
Q
L
H
H
P
K
L
I
N
L
H
D
A
F
E
D
K
Y
E
M
V
L
I
L
E
F
L
S
G
G
--
E
L
F
D
R
I
A
A
E
D
---
Y
K
M
S
E
A
E
V
I
N
Y
M
R
Q
A
C
E
G
L
K
H
M
H
E
H
S
I
V
H
L
D
I
K
P
E
N
I
M
C
E
-----------------
T
K
K
A
S
S
V
K
I
I
D
F
G
L
A
T
K
L
N
P
-
D
E
I
V
K
V
T
T
A
T
A
E
F
A
A
P
E
I
V
D
R
E
---
P
V
G
F
Y
T
D
M
W
A
I
G
V
L
G
Y
V
L
L
S
G
L
S
P
F
A
G
E
D
---
D
L
E
T
L
Q
N
V
K
R
C
D
W
E
F
D
E
D
A
F
--
S
S
V
S
P
E
A
K
D
F
I
K
---
N
L
L
Q
K
E
P
R
K
R
L
T
V
H
D
A
L
E
HPWLKGDHSNLTSRIPS
S
R
Y
N
K
I
R
Q
K
I
K
E
K
Y
A
D
W
P
A
P
Q
P
A
I
G
R
I
A
N
F
S
S
L
R
K
HRPQEYQ
I
Y
D
S
Y
F
DRKEA----------------------------
25
HHSearch
68.97
26%
-88
- C1 -
-
3C0I
1
CSKP_HUMAN
A:
[29-289]
--------------------------------------------------------------
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
-
I
-
N
R
E
T
G
---
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
S
P
G
--
L
S
T
E
D
L
K
R
E
A
S
I
C
H
M
L
K
-
H
P
H
I
V
E
L
L
E
T
Y
S
S
--
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
E
N
----------------
S
A
P
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
S
G
L
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
R
E
---
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
K
E
R
L
F
----
E
G
I
I
K
G
K
Y
K
M
N
-----
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
------------------
N
H
P
W
-----------------------------------------------------------------------------
24
HHSearch
66.37
26%
-91
- C1 -
-
3C0G
1
CSKP_HUMAN
B:
[29-289]
--------------------------------------------------------------
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
-
I
-
N
R
E
T
G
---
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
S
P
G
--
L
S
T
E
D
L
K
R
E
A
S
I
C
H
M
L
K
-
H
P
H
I
V
E
L
L
E
T
Y
S
S
--
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
E
N
----------------
S
A
P
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
S
G
L
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
R
E
---
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
K
E
R
L
F
----
E
G
I
I
K
G
K
Y
K
M
N
-----
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
------------------
N
H
P
W
-----------------------------------------------------------------------------
51
Fugue
66.11
19%
-102
- C1 -
-
1TKI
-
TITIN_HUMAN
A:
[18-338]
-----------------------------------------------------
K
E
L
Y
E
K
Y
M
I
A
E
D
L
G
R
G
E
F
G
I
V
H
R
C
-
V
-
E
T
S
S
K
---
K
T
Y
M
A
K
F
V
K
V
K
G
--------
T
D
Q
V
L
V
K
K
E
I
S
I
L
N
I
A
R
-
H
R
N
I
L
H
L
H
E
S
F
E
S
M
E
E
L
V
M
I
F
E
F
I
S
G
L
-
D
I
F
E
R
I
N
T
S
-
A
---
F
E
L
N
E
R
E
I
V
S
Y
V
H
Q
V
C
E
A
L
Q
F
L
H
S
H
N
I
G
H
F
D
I
R
P
E
N
I
I
Y
-----------------
Q
T
R
R
S
S
T
I
K
I
I
E
F
G
Q
A
R
Q
L
K
P
-
G
D
N
F
R
L
L
F
T
A
P
E
Y
Y
A
P
E
V
H
Q
H
D
---
V
V
S
T
A
T
D
M
W
S
L
G
T
L
V
Y
V
L
L
S
G
I
N
P
F
L
A
E
T
---
N
Q
Q
I
I
E
N
I
M
N
A
E
Y
-----
T
F
D
E
E
A
F
K
E
I
S
I
E
A
M
D
F
V
D
R
L
L
V
K
E
R
K
S
R
M
T
A
S
E
A
L
------------------
Q
------
H
P
W
L
K
Q
K
I
E
R
V
-
S
T
K
V
I
R
T
L
K
H
R
R
Y
Y
H
T
L
IKKDLNMVVSAARISCGGAIRSQKG
V
S
V
A
K
V
K
V
A
SI---------
4
PsiBlast_PDB
65.39
25%
-119
- C1 -
-
3HZT
9
?
A:
[10-290]
---------------------------------------------------------------
K
K
L
G
S
G
A
Y
G
E
V
L
L
C
-
K
-
D
K
L
T
G
A
E
R
A
I
K
I
I
K
K
S
S
V
T
T
T
S
N
S
G
A
L
L
D
-------
E
V
A
V
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
R
N
Y
Y
L
V
M
E
V
Y
R
G
G
-
E
L
F
D
E
I
I
L
R
Q
-----
K
F
S
E
V
D
A
A
V
I
M
K
Q
V
L
S
G
T
T
Y
L
H
K
H
N
I
V
H
R
D
L
K
P
E
N
L
L
L
----------------
E
S
K
S
R
D
A
L
I
K
I
V
D
F
G
L
S
A
H
F
-
E
V
G
--------
T
A
Y
Y
I
A
P
E
V
L
R
K
K
Y
D
----
E
K
C
D
V
W
S
C
G
V
I
L
Y
I
L
L
C
G
-
Y
P
P
F
--
G
G
Q
T
D
Q
E
I
L
K
R
V
E
K
G
K
F
S
F
D
P
P
D
W
T
Q
V
S
D
E
A
K
Q
L
V
K
L
-----
M
L
T
Y
E
P
S
K
R
I
S
A
E
E
A
L
---------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
64.47
27%
-33
- C1 -
-
4FII
-
PAK4_HUMAN
A:
[54-318]
-------------------------------------
V
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
-
R
S
S
G
K
L
V
----
A
V
K
K
M
D
L
R
K
Q
Q
R
R
E
L
L
F
N
E
V
--------
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
--
A
L
T
D
I
V
T
H
T
-----
R
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
----------------
H
D
G
R
---
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
R
L
---
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
------
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
---
L
K
N
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
-------------------------------------------------------------------------------------------------------
40
HHSearch
64.16
28%
-67
* C1 *
-
4XBR
1
INKA1_HUMAN (first)
A:
[100-348]
---------------------------------------------------------------
I
K
I
G
E
G
S
T
G
I
V
C
I
A
-
T
-
V
R
S
S
G
---
K
L
V
A
V
K
K
M
D
L
R
K
Q
Q
R
R
-------
E
L
L
F
N
E
V
V
I
M
R
D
Y
Q
-
H
E
N
V
V
E
M
Y
N
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
T
-----
R
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
-------------------
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
R
L
---
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
---
K
M
I
R
D
-
N
L
P
P
R
-----
L
K
N
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
------------------
K
H
P
F
L
A
---------------------------------------------------------------------------
54
Fugue
63.69
27%
-
- C1 -
-
3H4J
-
SNF1_SCHPO
B:
[27-356]
---------------------------
S
K
R
H
I
G
P
Y
I
I
R
-------------------------
E
T
L
G
E
G
S
F
G
K
V
K
L
A
-
T
-
H
Y
K
T
Q
---
Q
K
V
A
L
K
F
I
S
-
R
Q
L
L
K
K
S
D
M
H
M
R
V
E
R
E
I
S
Y
L
K
L
L
R
H
----
P
H
I
I
K
L
Y
D
V
I
T
T
P
T
D
I
V
M
V
I
E
Y
A
G
G
E
---
L
F
D
Y
I
V
E
K
K
----
R
M
T
E
D
E
G
R
R
F
F
Q
Q
I
I
C
A
I
E
Y
C
H
R
H
K
I
V
H
R
D
L
K
P
E
N
L
L
L
D
D
N
L
N
-------------------
V
K
I
A
D
F
G
L
S
N
I
M
T
D
-
G
N
F
L
K
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
N
G
--
K
L
Y
A
G
P
E
V
D
V
W
S
C
G
I
V
L
Y
V
M
L
V
G
R
L
P
---
F
D
D
E
F
I
P
N
L
F
K
K
V
N
S
C
V
Y
V
M
P
D
F
L
---------
S
P
G
A
Q
S
L
I
R
R
M
I
V
A
D
P
M
Q
R
I
T
----
I
------------------
Q
E
I
R
R
D
P
W
F
N
V
N
L
P
D
Y
L
R
-
P
M
E
E
V
Q
G
S
Y
A
D
S
R
I
V
S
KLGEAMGFSEDYIVEALRSDENNEVKEAYNLLHENQVIQEKLEHHH
14
PsiBlast_PDB
63.44
27%
-62
- C1 -
-
4NJD
1
A:
[20-268]
-----------------------------------------------------
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
-
R
S
S
G
K
L
V
----
A
V
K
K
M
D
L
R
K
Q
Q
R
R
E
L
L
F
N
E
V
--------
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
--
A
L
T
D
I
V
T
H
T
-----
R
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
----------------
H
D
G
R
---
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
R
L
---
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
------
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
---
L
K
N
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
-------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
63.41
27%
-
- C1 -
-
4FIJ
-
PAK4_HUMAN
A:
[299-563]
-------------------------------------
V
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
-
R
S
S
G
K
L
V
----
A
V
K
K
M
D
L
R
K
Q
Q
R
R
E
L
L
F
N
E
V
--------
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
--
A
L
T
D
I
V
T
H
T
-----
R
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
----------------
H
D
G
R
---
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
R
L
---
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
------
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
---
L
K
N
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
-------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
63.26
27%
-58
- C1 -
-
4APP
2
A:
[20-268]
-----------------------------------------------------
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
-
R
S
S
G
K
L
V
----
A
V
K
K
M
D
L
R
K
Q
Q
R
R
E
L
L
F
N
E
V
--------
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
--
A
L
T
D
I
V
T
H
T
-----
R
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
----------------
H
D
G
R
---
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
R
L
---
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
------
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
---
L
K
N
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
-------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
63.08
27%
-27
- C1 -
-
2F57
1
PAK5_HUMAN
A:
[25-289]
-------------------------------------
V
S
H
E
Q
F
R
A
A
L
Q
L
V
V
S
P
G
D
P
R
E
Y
L
A
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
-
T
E
K
H
T
G
----
K
Q
V
A
V
K
K
M
D
L
R
K
Q
Q
R
R
E
L
L
F
N
E
V
--------
V
I
M
R
D
Y
H
H
D
N
V
V
D
M
Y
S
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
--
A
L
T
D
I
V
T
H
T
-----
R
M
N
E
E
Q
I
A
T
V
C
L
S
V
L
R
A
L
S
Y
L
H
N
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
----------------
S
D
G
R
---
I
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
P
K
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
V
I
S
R
L
---
P
Y
G
T
E
V
D
I
W
S
L
G
I
M
V
I
E
M
I
D
G
E
P
P
Y
F
------
N
E
P
P
L
Q
A
M
R
R
I
R
D
S
L
P
P
R
V
---
K
D
L
H
K
V
S
S
V
L
R
G
F
L
D
L
M
L
V
R
E
P
S
Q
R
A
T
A
-------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
62.32
27%
-30
- C1 -
-
4XBR
1
INKA1_HUMAN (first)
A:
[74-338]
-------------------------------------
V
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
-
R
S
S
G
K
L
V
----
A
V
K
K
M
D
L
R
K
Q
Q
R
R
E
L
L
F
N
E
V
--------
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
--
A
L
T
D
I
V
T
H
T
-----
R
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
----------------
H
D
G
R
---
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
R
L
P
---
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
------
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
---
L
K
N
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
-------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
61.71
27%
-34
- C1 -
-
4FIE
1
PAK4_HUMAN
A:
[131-395]
-------------------------------------
V
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
-
R
S
S
G
K
L
V
----
A
V
K
K
M
D
L
R
K
Q
Q
R
R
E
L
L
F
N
E
V
--------
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
--
A
L
T
D
I
V
T
H
T
-----
R
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
----------------
H
D
G
R
---
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
R
L
P
Y
G
---
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
------
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
---
L
K
N
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
-------------------------------------------------------------------------------------------------------
36
HHSearch
61.34
25%
-70
- C1 -
-
2WEL
7
KCC2D_HUMAN
A:
[9-268]
--------------------------------------------------------------
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
-
M
-
K
I
P
T
G
---
Q
E
Y
A
A
K
I
I
N
T
K
K
L
S
A
-----
R
D
H
Q
K
L
E
R
E
A
R
I
C
R
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
--
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
----
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
K
----------------
G
A
A
V
K
L
A
D
F
G
L
A
I
E
V
Q
G
D
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
D
---
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
H
R
L
Y
---
Q
Q
I
K
A
G
A
Y
D
F
P
-----
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
------------------
K
H
P
W
I
----------------------------------------------------------------------------
17
PsiBlast_PDB
61.28
27%
-33
- C1 -
-
4FIG
1
?
A:
[54-318]
-------------------------------------
V
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
-
R
S
S
G
K
L
V
----
A
V
K
K
M
D
L
R
K
Q
Q
R
R
E
L
L
F
N
E
V
--------
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
--
A
L
T
D
I
V
T
H
T
-----
R
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
----------------
H
D
G
R
---
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
R
L
---
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
------
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
---
L
K
N
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
-------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
60.05
27%
-
- C- -
-
4FIH
-
PAK4_HUMAN
A:
[299-563]
-------------------------------------
V
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
-
R
S
S
G
K
L
V
----
A
V
K
K
M
D
L
R
K
Q
Q
R
R
E
L
L
F
N
E
V
--------
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
--
A
L
T
D
I
V
T
H
T
-----
R
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
----------------
H
D
G
R
---
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
R
L
---
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
------
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
---
L
K
N
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
-------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
59.90
27%
-61
- C1 -
-
2CDZ
1
A:
[27-275]
-----------------------------------------------------
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
-
R
--
G
K
L
V
----
A
V
K
K
M
D
L
R
K
Q
Q
R
R
E
L
L
F
N
E
V
--------
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
--
A
L
T
D
I
V
T
H
T
-----
R
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
----------------
H
D
G
R
---
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
R
L
---
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
------
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
---
L
K
N
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
-------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
59.39
27%
-55
- C1 -
-
5BMS
1
A:
[17-265]
-----------------------------------------------------
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
-
R
S
S
G
K
L
V
----
A
V
K
K
M
D
L
R
K
Q
Q
R
R
E
L
L
F
N
E
V
--------
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
--
A
L
T
D
I
V
T
H
T
-----
R
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
----------------
H
D
G
R
---
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
R
L
---
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
------
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
---
L
K
N
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
-------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
59.22
27%
-33
- C1 -
-
4FIF
1
PAK4_HUMAN
A:
[54-318]
-------------------------------------
V
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
-
R
S
S
G
K
L
V
----
A
V
K
K
M
D
L
R
K
Q
Q
R
R
E
L
L
F
N
E
V
--------
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
--
A
L
T
D
I
V
T
H
T
-----
R
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
----------------
H
D
G
R
---
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
R
L
---
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
------
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
---
L
K
N
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
-------------------------------------------------------------------------------------------------------