@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_21_0210: (2018-03-09 )
MTASLSSSPVRHPSVDNAAIPAASHHIPPPLNGYAFLEHRRSALSHDTFIARDVRQQQHPEQQDNDQAKVIIRVYALEYLRRDEECRFALERECLAARLVVHPHLLPLGSPFASKTDLFVVEKYCAGGDLYELMVSLAKEGPIASETGAAKGEAPPRSSTGLPISTVKRFMRELLSAVQYLHRTCGLVHRNIKLETLFIDEEQHLRLGSFGLCAVLPPPSVATGDREGALDAPEDKASSSHAPLRLCCGSKHYAAPELVQGHPYQGEGVDAWACGVVLFALLTGCFPFDSDDGDEALFRLLCGDVESHLAQHPAMAAIEDPQACDLVRNLLRPNPNARYTVSEALEHPYLWEV
Atome Classification :
(20 SA)
--------.........10........20........30.....---...40........50....---------....60........70.....-...80----.----......---.90..-----......100-------........110.......120.......130.......140.......150.......160.......170.......180.-......190.......--200---.--.---.....210.......220.......230.......240.......250.......260----..---......270.......280.......290.......300-..-.....310.......320.......330.....--..-----340.......350--...--------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
--------MTASLSSSPVRHPSVDNAAIPAASHHIPPPL
N
G
Y
A
F
---
L
E
H
R
R
S
ALSH
D
T
F
I
A
R
D
V
R
---------
Q
QQHPEQQDNDQ
A
K
V
I
I
R
V
Y
A
-
L
E
Y
L
R----R----
D
E
E
C
R
F
---
A
L
E
R
E
-----
C
L
A
A
R
L
V-V-------HPHLLPLGSPFASKT
D
L
F
V
V
EKYCAG
G
D
L
Y
E
L
M
V
S
L
A
KEGPIASETGAAKGEAPPRSSTGL
P
I
S
T
V
K
R
F
M
R
E
L
L
S
A
V
Q
Y
L
H
R
-
T
C
G
L
V
HR
N
I
K
L
E
T
L
F
I--D
E
E
---Q--
H
---
L
RLGSF
G
L
C
A
VLPPPSVATGDREGALDAPEDKASSSHA
P
L
R
L
C
CGSKHYAAPELVQG-----HP---YQGEGV
D
A
W
A
C
G
V
V
L
F
A
L
L
T
GCFPFDSDD
G
D
E
A
L
F
R
L
L
C-G
D
-
V
E
S
H
L
A
QHPAMAAIED
P
Q
A
C
D
L
V
R
N
L
LRPNPNA--
R
Y
-----
T
V
S
E
ALEHPYL----WEV--------------------------------------------------------------------
31
HHSearch
72.42
29%
-151
- C1 -
-
5K00
1
MELK_HUMAN
A:
[6-264]
-------------------------------------
L
L
K
Y
Y
E
L
---
H
E
T
I
G
T
G
--
A
K
V
K
L
A
C
H
I
L
-------------------
T
G
E
M
V
A
I
K
I
M
D
-
K
N
T
L
G
-----------
S
D
L
P
---
R
I
K
T
E
-----
I
E
A
L
K
N
L
-
R
-------
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
----------------------
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
-
Q
-
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
--
D
E
Y
---
H
--
K
---
L
K
L
I
D
F
G
L
C
A
K
P
---------------------------------
S
L
A
Y
A
A
P
E
L
I
Q
G
-----
K
S
---
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
M
A
-
L
Y
K
K
I
M
--
R
-
G
K
Y
D
------
V
P
K
W
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
--
R
I
-----
S
M
K
N
L
L
N
H
P
W
I
----
M
Q
---------------------------------------------------------------------
27
HHSearch
71.14
28%
-68
- C1 -
-
3C0I
1
CSKP_HUMAN
A:
[21-292]
------------------------------------
L
F
E
D
V
Y
E
L
---
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
-------------------
T
G
Q
Q
F
A
V
K
I
V
D
-
V
A
K
F
T
----
S
S---
P
G
L
S
T
E
---
D
L
K
R
E
-----
A
S
I
C
H
M
L
-
K
-------
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
------------------
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
-
N
-
N
I
I
H
R
D
V
K
P
H
C
V
L
L
--
A
S
K
ENS
A
--
P
---
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
S
G
L
---------------------
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
R
-----
E
P
---
Y
-
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
K
E
R
--
L
F
E
G
I
I
--
K
-
G
K
--
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
--
R
I
-----
T
V
Y
E
A
L
N
H
P
W
L
----
K
E
---------------------------------------------------------------------
43
Fugue
70.95
23%
-58
- C1 -
-
1KOB
1
?
A:
[23-374]
-------------------
I
N
D
Y
D
K
F
Y
E
D
I
W
K
K
Y
V
P
Q
P
V
---------
E
V
K
Q
G
S
V
Y
D
Y
Y
D
I
L
E
E
L
G
---------
S
G
A
F
G
V
V
H
R
C
V
E
K
A
T
G
R
V
F
V
A
-
K
F
I
N
T
----
P
----
Y
P
L
D
K
Y
---
T
V
K
N
E
-----
I
S
I
M
N
Q
L
-
H
-------
H
P
K
L
I
N
L
H
D
A
F
E
D
K
Y
E
M
V
L
I
L
E
F
L
S
G
G
E
L
F
D
R
I
A
A
---------------------
E
D
Y
K
M
S
E
A
E
V
I
N
Y
M
R
Q
A
C
E
G
L
K
H
M
H
E
-
H
-
S
I
V
H
L
D
I
K
P
E
N
I
M
C
--
E
T
K
---
K
AS
S
---
V
K
I
I
D
F
G
L
A
T
K
L
N
P
D
E
----------------------
I
V
K
V
T
T
A
T
A
E
F
A
A
P
E
I
V
D
R
-----
E
P
---
V
-
G
F
Y
T
D
M
W
A
I
G
V
L
G
Y
V
L
L
S
G
L
S
P
F
A
G
E
D
D
L
E
T
L
Q
N
V
K
R
-
C
D
-
W
E
F
D
E
D
A
F
S
S
V
----
S
P
E
A
K
D
F
I
K
N
L
L
Q
K
E
P
R
K
--
R
L
-----
T
V
H
D
A
L
E
H
P
W
L
----
K
G
D
HSNLTSRIPSSRY
N
K
I
R
Q
K
I
K
E
K
Y
ADWPAPQPAIGRIANFSSLRKHRPQEYQ
I
Y
D
S
Y
F
DRKEA-----
25
HHSearch
70.20
28%
-71
- C1 -
-
3C0G
1
CSKP_HUMAN
B:
[21-292]
------------------------------------
L
F
E
D
V
Y
E
L
---
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
-------------------
T
G
Q
Q
F
A
V
K
I
V
D
-
V
A
K
F
T
----
S
S---
P
G
L
S
T
E
---
D
L
K
R
E
-----
A
S
I
C
H
M
L
-
K
-------
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
------------------
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
-
N
-
N
I
I
H
R
D
V
K
P
H
C
V
L
L
--
A
S
K
ENS
A
--
P
---
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
S
G
L
---------------------
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
R
-----
E
P
---
Y
-
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
K
E
R
--
L
F
E
G
I
I
--
K
-
G
K
--
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
--
R
I
-----
T
V
Y
E
A
L
N
H
P
W
L
----
K
E
---------------------------------------------------------------------
32
HHSearch
69.73
30%
-33
- C1 -
-
2Y7J
1
PHKG2_HUMAN
D:
[92-365]
-------------------------------------
F
Y
Q
K
Y
D
P
---
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
-------------------
T
G
H
E
F
A
V
K
I
M
E
-
V
---
R
LSPE
Q
----
L
E
E
V
R
E
---
A
T
R
R
E
-----
T
H
I
L
R
Q
V
A
G
-------
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
V
----------------------
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
-
N
-
N
I
V
H
R
D
L
K
P
E
N
I
L
L
--
D
D
N
---
M
--
Q
---
I
R
L
S
D
F
G
F
S
C
H
L
E
P
G
E
----------------------
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
C
SMDET
H
P
---
G
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
R
R
Q
I
L
M
-
L
R
M
I
M
E
G
Q
-
Y
Q
F
S
S
P
----
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
--
R
L
-----
T
A
E
Q
A
L
Q
H
P
F
F
----
E
R
---------------------------------------------------------------------
37
HHSearch
69.57
25%
-71
- C1 -
-
4GV1
5
AKT1_HUMAN
A:
[7-275]
--------------------------------------
M
N
E
F
E
Y
---
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
-------------------
T
G
R
Y
Y
A
M
K
I
L
K
-
K
E
V
I
V
----
A
----
K
-
D
E
V
A
---
H
T
L
T
E
-----
N
R
V
L
Q
N
S
-
R
-------
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
----------------------
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
-
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
--
D
K
D
---
G
--
H
---
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
---------------------
A
T
M
K
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
D
---
Y
-
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
E
K
L
-
F
E
L
I
L
--
M
-
E
E
I
R
F
------
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
GGGS
E
D
A
K
E
I
M
Q
H
R
F
F
----
A
G
---------------------------------------------------------------------
45
Fugue
69.07
20%
-76
- C1 -
-
1TKI
-
TITIN_HUMAN
A:
[18-338]
--------------------------------
K
E
L
Y
E
K
Y
M
I
A
E
D
---
L
G
R
G
E
F
G
I
V
H
R
C
V
E
T
S
S
K
---------------------------
K
T
Y
M
-
A
K
F
V
K
----
V
----
K
G
T
D
Q
V
---
L
V
K
K
E
-----
I
S
I
L
N
I
A
-
R
-------
H
R
N
I
L
H
L
H
E
S
F
E
S
M
E
E
L
V
M
I
F
E
F
I
S
G
L
D
I
F
E
R
I
N
T
---------------------
S
A
F
E
L
N
E
R
E
I
V
S
Y
V
H
Q
V
C
E
A
L
Q
F
L
H
S
-
H
-
N
I
G
H
F
D
I
R
P
E
N
I
I
Y
QT
R
R
S
---
S
--
T
---
I
K
I
I
E
F
G
Q
A
R
Q
L
K
P
G
D
----------------------
N
F
R
L
L
F
T
A
P
E
Y
Y
A
P
E
V
H
Q
H
-----
D
V
---
V
-
S
T
A
T
D
M
W
S
L
G
T
L
V
Y
V
L
L
S
G
I
N
P
F
L
A
E
T
N
Q
Q
I
I
E
N
I
M
N
-
A
E
-
Y
T
F
D
E
E
A
F
K
E
I
----
S
I
E
A
M
D
F
V
D
R
L
L
V
K
E
R
K
S
--
R
M
-----
T
A
S
E
A
L
Q
H
P
W
L
----
K
Q
K
IERVSTKVIRT
L
K
H
R
R
Y
Y
H
T
L
IKKDLNMVVSAARISCGGAIRSQKG
V
S
V
A
K
V
K
V
A
SI-----------
47
Fugue
68.82
28%
-
- C1 -
-
3H4J
-
SNF1_SCHPO
B:
[27-356]
----------------------------------
S
K
R
H
I
G
P
Y
I
I
---
R
E
T
L
G
E
G
S
F
G
K
V
K
L
A
T
H
Y
K
---------
T
Q
Q
----------
K
V
A
L
K
F
I
S
-
R
Q
L
L
K
----
K
----
S
D
M
-
H
M
---
R
V
E
R
E
-----
I
S
Y
L
K
L
L
-
R
-------
H
P
H
I
I
K
L
Y
D
V
I
T
T
P
T
D
I
V
M
V
I
E
Y
-
A
G
G
E
L
F
D
Y
I
V
E
K
K
R
----------------------
M
T
E
D
E
G
R
R
F
F
Q
Q
I
I
C
A
I
E
Y
C
H
R
-
H
-
K
I
V
H
R
D
L
K
P
E
N
L
L
L
--
D
D
N
---
L
--
N
---
V
K
I
A
D
F
G
L
S
N
I
M
T
D
G
N
----------------------
F
L
K
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
N
G
-----
K
L
---
Y
A
G
P
E
V
D
V
W
S
C
G
I
V
L
Y
V
M
L
V
G
R
L
P
F
D
D
E
F
I
P
N
L
F
K
K
V
N
S
-
C
---
V
Y
V
M
P
D
F
L
------
S
P
G
A
Q
S
L
I
R
R
M
I
V
A
D
P
M
Q
--
R
I
-----
T
I
Q
E
I
R
R
D
P
W
F
----
N
V
N
LPDYLRPMEEVQGSYADSRIVSKLGEAMGFSEDYIVEALRSDENNEVKEAYNLLHENQVIQEKLEHHH
11
PsiBlast_PDB
68.63
27%
-145
- C1 -
-
5KQ5
2
?
A:
[63-399]
-------------------------------------------------------------------------------------------------------------------------
I
R
R
E
-----
I
Q
N
L
K
L
F
-
R
-------
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
---
I
C
K
N
G
R
L
D
E
K
E
S
-------------------
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
-
H
M
-
V
V
H
R
D
L
K
P
E
N
V
L
L
--
D
A
H
---
M
--
N
---
A
K
I
A
D
F
G
L
S
N
M
M
----------------------
S
D
G
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
-----
R
L
---
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
-
D
D
H
V
P
T
L
F
K
K
I
C
-
D
G
-
I
-
F
Y
T
P
Q
Y
L
------
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
--
R
A
-----
T
I
K
D
I
R
E
H
E
W
F
---------------------------------------------------------------------------
9
PsiBlast_PDB
68.29
27%
-148
- C1 -
-
4QFR
2
?
A:
[63-401]
-------------------------------------------------------------------------------------------------------------------------
I
R
R
E
-----
I
Q
N
L
K
L
F
-
R
-------
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
---
I
C
K
N
G
R
L
D
E
K
E
S
-------------------
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
-
H
M
-
V
V
H
R
D
L
K
P
E
N
V
L
L
--
D
A
H
---
M
--
N
---
A
K
I
A
D
F
G
L
S
N
M
M
----------------------
S
D
G
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
-----
R
L
---
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
-
D
D
H
V
P
T
L
F
K
K
I
C
-
D
G
-
I
-
F
Y
T
P
Q
Y
L
------
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
--
R
A
-----
T
I
K
D
I
R
E
H
E
W
F
---------------------------------------------------------------------------
28
HHSearch
68.14
30%
-37
- C1 -
-
2Y7J
1
PHKG2_HUMAN
C:
[92-365]
-------------------------------------
F
Y
Q
K
Y
D
P
---
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
-------------------
T
G
H
E
F
A
V
K
I
M
E
-
V
T
A
E
R
----
L
SPEQ
L
E
E
V
R
E
---
A
T
R
R
E
-----
T
H
I
L
R
Q
V
A
G
-------
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
V
----------------------
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
-
N
-
N
I
V
H
R
D
L
K
P
E
N
I
L
L
--
D
D
N
---
M
--
Q
---
I
R
L
S
D
F
G
F
S
C
H
L
E
P
G
E
----------------------
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
C
SMDET
H
P
---
G
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
R
R
Q
I
L
-
M
L
R
M
I
M
E
G
Q
-
Y
Q
F
S
S
P
----
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
--
R
L
-----
T
A
E
Q
A
L
Q
H
P
F
F
----
E
R
---------------------------------------------------------------------
50
Fugue
67.88
28%
-8
- C1 -
-
5KCV
1
AKT1_HUMAN
A:
[20-452]
IV
K
E
G
W
L
H
K
R
G
E
Y
I
T
W
R
P
R
Y
F
L
L
K
N
D
G
T
F
I
G
Y
K
E
R
P
A
P
L
N
N
F
S
V
AQ
C
Q
L
M
K
T
E
R
P
R
P
N
T
F
I
I
R
C
L
Q
WT
T
V
I
E
R
T
F
H
V
E
T
P
E
E
R
E
E
W
T
T
A
I
Q
R
V
T
M
N
E
F
E
Y
L
K
----
L
----
L
G
K
G
T
F
G
K
V
I
L
V
K
E
KATG
R
Y
Y
A
M
K
I
L
-
K
KV
L
Q
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
---
E
L
F
F
H
L
S
R
E
R
V
-------------------
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
--
D
K
D
---
G
--
H
---
I
K
I
T
D
F
G
L
C
-------------------------------------
P
E
Y
L
A
P
E
V
L
E
D
-----
N
D
---
Y
-
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
-
H
E
K
L
F
E
L
I
L
-
M
E
-
E
I
R
F
P
R
T
L
G
-------
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
GGGSE
D
A
K
E
I
M
Q
H
R
F
F
AGIV
W
Q
H
V
Y
E
KKLSPPFKPQVTSETDTRYF---------------------------------------------
10
PsiBlast_PDB
67.12
27%
-148
- C1 -
-
4QFS
2
A:
[63-401]
-------------------------------------------------------------------------------------------------------------------------
I
R
R
E
-----
I
Q
N
L
K
L
F
-
R
-------
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
---
I
C
K
N
G
R
L
D
E
K
E
S
-------------------
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
-
H
M
-
V
V
H
R
D
L
K
P
E
N
V
L
L
--
D
A
H
---
M
--
N
---
A
K
I
A
D
F
G
L
S
N
M
M
----------------------
S
D
G
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
-----
R
L
---
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
-
D
D
H
V
P
T
L
F
K
K
I
C
-
D
G
-
I
-
F
Y
T
P
Q
Y
L
------
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
--
R
A
-----
T
I
K
D
I
R
E
H
E
W
F
---------------------------------------------------------------------------
14
PsiBlast_PDB
66.15
27%
-157
- C1 -
-
4CFH
1
AAPK1_RAT
A:
[80-346]
-------------------------------------------------------------------------------------------------------------------------
I
R
R
E
-----
I
Q
N
L
K
L
F
-
R
-------
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
---
I
C
K
N
G
R
L
D
E
K
E
S
-------------------
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
-
H
M
-
V
V
H
R
D
L
K
P
E
N
V
L
L
--
D
A
H
---
M
--
N
---
A
K
I
A
D
F
G
L
S
N
M
M
----------------------
S
D
G
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
-----
R
L
---
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
-
D
D
H
V
P
T
L
F
K
K
I
C
-
D
G
-
I
-
F
Y
T
P
Q
Y
L
------
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
--
R
A
-----
T
I
K
D
I
R
E
H
E
W
F
---------------------------------------------------------------------------
42
HHSearch
65.22
22%
-100
- C1 -
-
4WOT
1
ROCK2_HUMAN
B:
[67-337]
-------------------------------------
K
A
E
D
Y
D
V
---
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
A
-------------------
S
Q
K
V
Y
A
M
K
L
L
S
-
K
F
E
M
I
----
K
----
R
-
S
D
S
A
---
F
F
W
E
E
-----
R
D
I
M
A
F
A
-
N
-------
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
-----------------------
D
V
P
E
K
W
A
K
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
-
G
L
I
H
R
D
V
K
P
D
N
M
L
L
--
D
K
H
---
G
--
H
---
L
K
L
A
D
F
G
T
C
M
K
M
D
E
T
G
M
--------------------
V
H
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
-----
Q
G
GDG
F
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
-
T
Y
S
K
I
M
-
D
H
K
N
S
L
C
F
P
E
----
D
A
E
I
S
K
H
A
K
N
L
I
C
A
F
L
T
D
R
E
V
R
LG
R
N
-----
G
V
E
E
I
R
Q
H
P
F
F
----
K
N
---------------------------------------------------------------------
23
HHSearch
64.80
22%
-81
- C1 -
-
2X4F
4
MYLK4_HUMAN
A:
[89-348]
---------------------------------------
Y
T
V
S
K
---
T
E
I
L
G
-----
Q
V
H
K
C
E
E
T
A
-------------------
T
G
L
K
L
A
A
K
I
I
K
-
T
R
G
M
K
------------
D
K
E
---
E
V
K
N
E
-----
I
S
V
M
N
Q
L
-
D
-------
H
A
N
L
I
Q
L
Y
D
A
F
E
S
K
N
D
I
V
L
V
M
E
Y
V
D
G
G
E
L
F
D
R
I
I
D
E
S
---------------------
Y
N
L
T
E
L
D
T
I
L
F
M
K
Q
I
C
E
G
I
R
H
M
H
Q
-
M
-
Y
I
L
H
L
D
L
K
P
E
N
I
L
C
VN
R
D
A
---
K
--
Q
---
I
K
I
I
D
F
G
L
A
R
R
Y
K
P
R
E
----------------------
K
L
K
V
N
F
G
T
P
E
F
L
A
P
E
V
V
N
Y
-----
D
F
---
V
-
S
F
P
T
D
M
W
S
V
G
V
I
A
Y
M
L
L
S
G
L
S
P
F
L
G
D
N
D
A
E
T
L
N
N
I
L
A
-
C
R
-
W
D
L
----
E
D
E
E
F
Q
D
I
S
E
E
A
K
E
F
I
S
K
L
L
I
K
E
K
S
W
--
R
I
-----
S
A
S
E
A
L
K
H
P
W
L
----
S
D
---------------------------------------------------------------------
16
PsiBlast_PDB
64.73
27%
-154
- C1 -
-
4REW
1
AAPK1_HUMAN
A:
[53-389]
-------------------------------------------------------------------------------------------------------------------------
I
R
R
E
-----
I
Q
N
L
K
L
F
-
R
-------
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
---
I
C
K
N
G
R
L
D
E
K
E
S
-------------------
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
-
H
M
-
V
V
H
R
D
L
K
P
E
N
V
L
L
--
D
A
H
---
M
--
N
---
A
K
I
A
D
F
G
L
S
N
M
M
----------------------
S
D
G
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
-----
R
L
---
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
-
D
D
H
V
P
T
L
F
K
K
I
C
-
D
G
-
I
-
F
Y
T
P
Q
Y
L
------
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
--
R
A
-----
S
I
K
D
I
R
E
H
E
W
F
---------------------------------------------------------------------------
30
HHSearch
64.68
24%
-84
- C1 -
-
2BDW
-
KCC2D_CAEEL
A:
[5-273]
----------------------------------
S
T
K
F
S
D
N
Y
D
V
---
K
E
E
L
G
K
G
A
F
S
V
V
R
R
C
V
H
K
T
-------------------
T
G
L
E
F
A
A
K
I
I
N
-
T
K
K
L
S
----
A
------
R
D
F
Q
---
K
L
E
R
E
-----
A
R
I
C
R
K
L
-
Q
-------
H
P
N
I
V
R
L
H
D
S
I
Q
E
E
S
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
----------------------
F
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
I
A
Y
C
H
S
-
N
-
G
I
V
H
R
N
L
K
P
E
N
L
L
L
--
A
S
K
AKG
A
--
A
---
V
K
L
A
D
F
G
L
A
I
E
V
N
D
S
E
----------------------
A
W
H
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
K
K
-----
D
P
---
Y
-
S
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
H
R
-
L
Y
A
Q
I
K
--
A
-
G
A
Y
D
Y
P
S
--
P
E
W
D
T
V
T
P
E
A
K
S
L
I
D
S
M
L
T
V
N
P
K
K
--
R
I
-----
T
A
D
Q
A
L
K
V
P
W
I
----
C
N
---------------------------------------------------------------------
17
PsiBlast_PDB
63.31
29%
-93
- C1 -
-
3C0G
1
CSKP_HUMAN
A:
[73-300]
-------------------------------------------------------------------------------------------------------------------------
L
K
R
E
-----
A
S
I
C
H
M
L
-
K
-------
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
------------------
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
-
N
-
N
I
I
H
R
D
V
K
P
H
C
V
L
L
--
A
S
K
---
E
--
N
S
A
P
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
S
G
L
V
A
G
G
R
---------------------
V
G
T
P
H
F
M
A
P
E
V
V
K
R
-----
E
P
---
Y
-
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
K
E
-----
R
L
F
E
-
G
I
-
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
--
R
I
-----
T
V
Y
E
A
L
N
H
P
W
L
----
K
E
---------------------------------------------------------------------
3
PsiBlast_PDB
62.58
30%
-83
- C1 -
-
3MFS
1
CSKP_HUMAN
A:
[73-292]
-------------------------------------------------------------------------------------------------------------------------
L
K
R
E
-----
A
S
I
C
H
M
L
-
K
-------
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
------------------
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
-
N
-
N
I
I
H
R
D
V
K
P
E
N
V
L
L
--
A
S
K
---
E
--
N
S
A
P
V
K
L
G
D
F
G
V
A
I
Q
L
G
E
S
G
L
V
A
G
G
R
---------------------
V
G
T
P
H
F
M
A
P
E
V
V
K
R
-----
E
P
---
Y
-
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
K
E
-----
R
L
F
E
-
G
I
-
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
--
R
I
-----
T
V
Y
E
A
L
N
H
P
W
L
----
K
E
---------------------------------------------------------------------