@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_21_0330: (2018-03-09 )
MATVDTVRGRYSSYKLLNEVGRGGSALVYRAQDVATRKDVAVKQLFGNRPQDMEDWLREVDALHTLNNHHCPHVVKYLDHMQQHDRLFLVEEFTEHGSLLRRLKENSKLPEDIACRYIYQVLTALYHMAPWGVVHGDLKASNILLFDGDVVKLTDFALRSHGEDDHEDGERRTTAASTPSAEALPLMRGSRAGRGAGEECSGSALSVFRGSAYWAAPEVLAGASKATAASDIWSVGCLAVELLTGAPPYFERPIHNAIHHILKSYYEVLCESEASRVGAAGTSRASTNPATPSAAMGSGDDDGPRGPRKKKNGAKDGCGAAPQKTDVASARRATATTSTHNPPKEPVDAVKTAASSGAVCASDRNEVATPLCEAALLPPLPEDVHLSDECLSFLRMCFRPRAVDRPSAGELLHDPWFLDCTVPQLLRAAREGRPMNGTTGDESVSAGTSSGSRFGVIEQWVKRNLTCDNESRCEAWLNSDALPLLVPVLTPRIMTPKYIGNVMWCFSQFAESRSALATLFVDRLGSTELWGVEELTSACDADHLATLFRRCCATQDAQVPVYTPADPRALRFVLGLEKEKVLACVRALHSRLVLEPTAAAMAADASSLATATDDTAVDLNDCPASSRDPAAPAHAAPDRAPASLQEQHEQQQRARERLLSDGGAAVLCQCVEAQCKAAFLSNTAPMMEWSTMNLLFDVLCTIEPLAGGQALLWGLGADLSGGHTSPSSTVGTGGGGAAILKSLTVVVNPCGGRGGGELNSTWEKSSPGTGPPLLVSPISVSPQESIPTTAAAAGGGGGPLSSLGSTMGFGCHTVSGLPPESVQWATSMTWLLAVQEAARHLCETAVRLLTRYIPVARRCRAEYLEKAGVSLTATLVLVASSEVVSTDVRCAAVEALPQLQASSLRATRYLRDPVRCIALLALTLKRSYGVPALTSCLLTAITAMTSEKQMLAACTGCPWVWESLVSLLREVEAADKAAAAGGKRSSSALHSAASTDGGAAEGAVAPPALVAAAASPTSVKSPSASSSSGAVAAGGAAVFADIVVLLSRWFAEVTPTALLSSAVTAAAAASEAIPALGHPAASLPLPVLLQTLRCQLIALSQNGRVCHGDLMPDVAKALRHLAPLEAAAVAASTSTATVA
Atome Classification :
(20 SA)
-----------------.........10........20........30...-----.....40....-...-.50--------.........60........70........80...---..-...90........100.-..--------...---.110..--.....120.......130.......140.....--..---150.......160.......170.......180.......190.......200.......210.......220-----.......230.......240..-.....250........260.-------------....-------------------..270---.------.......280---..-------.......290.......300-.......310.......320.......330...-....340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.....--..550.......560.......570.......580.......590------------.........600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-----------------MA
T
V
D
T
V
RG
R
Y
S
S
Y
K
L
L
N
E
VGRGG
S
A
L
V
Y
R
AQDV-----AT
R
K
D
V
A
V
K
Q
L
-FGN-R
P
---------
Q
D
M
E
D
W
L
R
E
V
D
A
L
H
TLNNHH
C
P
H
V
V
K
Y
L
D
H
M
Q
QH---DR-
L
F
L
V
E
E
F
T
E
H
G
S
L
L
R
R
L
-
K
E--------NSK---L
P
E
D
I
A
--
C
R
Y
I
Y
Q
V
L
T
A
L
YHMAPWG
V
V
HGDLKAS
N
I
L
L
FD--G
D
---
V
V
K
L
T
D
F
A
L
RSHGEDDHEDGERRTTAASTPSAEALPLMRGSRAGRGAGEECSGS
A
L
S
V
FRGSAYWA
A
P
E
V
LAG-----ASKAT
A
A
S
D
I
W
S
V
G
C
L
A
V
E
L
LT-GA
P
P
Y
F
-
E
R
P
I
H
N
A
I
H
H
I
L
K
-------------
S
Y
Y
E
-------------------
V
L
C
E
----
S
------
E
A
S
RVGAA-----GT-------SRASTNPATPSAAMGSGDDD-GPRGPRKKKNGAKDGCGAAPQK
T
D
V
A
SARRATA-TTSTHNPPKE
P
V
D
A
V
K
T
AASSG
A
V
CASD
R
N
E
V
A
T
P
L
C
E
A
ALLPPLPEDVHL
S
D
E
C
L
S
F
L
R
M
CFRPRAVDRPSAGELLHD
P
W
FLDC
T
V
P
Q
L
L
R
A
A
REGRPMNGTTGDESVSAGTSSGSR
F
G
V
I
E
Q
W
V
K
RNLTCD
N
E
S
R
C
E
A
W
L
NSDA
L
P
L
L
V
P
VLTPRIM
T
P
K
Y
I
G
N
V
M
W
C
F
S
Q
F
A
E
S
R
S
A
L
A
T
L
F
V
D
RLGSTELW
G
V
E
E
L
T
S
AC
D
A
D
H
L
A
T
L
--
F
R
R
CCATQDAQV
P
V
YTPAD
P
R
A
L
R
F
V
LGL
E
K
E
K
V
L
A
C
V
R
A
L
H
S--------------RLVLEP
T
A
A
A
MAA
D
A
S
S
LATATDD
T
A
V
DLNDCPASSRDPAAPAHAAPDRAP
A
S
L
Q
E
Q
H
E
Q
Q
Q
R
A
R
E
R
L
LSDG
G
A
A
V
L
C
Q
C
V
E
A
Q
C
K
A
A
F
LSNTAPMM
E
W
S
T
M
N
L
L
F
D
V
L
C
TIEPLAGG
Q
A
L
L
WGLGADLSGGHTSPSSTVGTGG
G
G
A
A
I
L
K
S
L
T
V
V
V
NPCGGRGGGELNSTWEKSSPGTGP
P
L
L
V
SPISVSPQESIPTTAAAAGGGGG
P
L
S
S
L
G
STMGFGCHTVSGLPPE
S
V
Q
W
A
T
S
M
T
W
L
L
A
V
Q
E
A
A
R
H
L
C
E
T
A
V
R
L
L
T
R
Y
I
P
V
A
R
R
C
R
A
E
Y
L
E
KAGV
S
L
T
A
T
L
V
L
V
ASSEVVSTD
V
R
C
A
A
V
E
A
L
P
Q
L
Q
A
S
S
L
R
A
T
R
Y
L
R
D
P
V
R
C
I
A
L
L
A
L
T
L
K
RSYG
V
P
A
L
T
S
C
L
L
T
A
I
T
A
MTS
E
K
Q
M
L
A
A
CTG
C
P
W
V
W
E
S
L
V
S
L
L
R
E
V
E
A
A
D
K
A
AAAGGKRS
S
S
A
L
HSAASTDGGAAEGAVA
P
P
A
L
V
AAAASPTSVKSPSASSSSGAVAAG
G
A
A
V
F
A
D
I
V
V
L
L
S
R
W
F
A
EV
T
P
T
A
L
L
S
S
A
V
T
A
A
A
A
A
S
EAIPALGHPAASL
P
L
P
V
L
L
Q
T
L
R
C
Q
L
I
A
LSQNGRVCHG
D
L
M
P
D
V
A
K
A
L
R
H
LA
P
L
E
A
A
AVAASTSTATVA
51
Fugue
86.19
16%
-
- C1 -
-
3QA8
-
?
A:
[16-666]
-------------------------------
E
M
K
E
R
L
G
T
G
G
F
G
Y
V
L
R
W
I
H
Q
-----
D
T
G
E
Q
V
A
I
K
Q
C
-
R
Q
E
L
S
P
---------
K
N
R
E
R
W
C
L
E
I
Q
I
M
K
K
L
N
H
P
N
V
V
S
A
R
E
V
P
D
G
L
Q
K
L
APN
D
L
-
P
L
L
A
M
E
Y
C
E
G
G
D
L
R
K
Y
L
-
N
Q
--------
F
E
N
CCG
L
K
E
G
P
I
--
R
T
L
L
S
D
I
S
S
A
L
R
Y
L
H
E
N
R
I
I
H
R
D
L
K
P
E
N
I
V
L
Q
P
--
G
P
Q
R
L
I
H
K
I
I
D
L
G
Y
-------------------------------------
A
K
E
L
D
Q
G
E
L
C
T
E
F
V
G
T
L
Q
Y
L
A
P
E
L
L
E
Q
------
K
K
Y
T
V
T
V
D
Y
W
S
F
G
T
L
A
F
E
C
I
T
-
G
F
R
P
F
L
-
P
---
N
W
Q
P
V
Q
W
H
G
-------------
K
V
R
I
-------------------
V
V
Y
D
----
D
------
L
T
G
A
V
K
F
S
-----
S
V
-------
L
P
T
P
N
H
L
S
G
I
L
A
G
K
L
E
R
W
L
Q
-
C
M
L
M
W
H
Q
R
T
D
P
Q
N
P
N
V
G
C
F
Q
A
L
D
S
I
L
S
L
K
L
L
S
V
M
N
M
V
S
G
R
V
H
T
Y
P
V
T
E
N
E
N
L
Q
N
L
K
S
W
L
Q
Q
D
T
G
---
I
P
E
E
E
Q
E
L
L
Q
A
S
G
L
A
L
N
-------------
S
A
Q
P
L
T
Q
Y
V
I
D
C
T
V
G
D
L
I
F
L
F
D
N
R
K
I
S
L
P
A
H
P
E
S
V
S
I
V
L
Q
D
P
K
R
P
L
T
Y
T
H
L
R
R
V
W
G
Q
I
W
Q
T
I
R
A
L
K
E
D
C
A
R
L
L
Q
G
Q
R
T
S
M
V
N
L
L
R
Y
N
T
E
L
S
K
K
K
N
S
M
T
S
E
C
E
Q
L
K
A
K
L
D
F
F
R
S
S
I
Q
I
D
L
E
K
Y
S
E
Q
M
E
F
G
I
T
S
E
K
L
L
S
A
W
R
E
M
E
Q
A
V
E
L
C
GR
E
R
E
V
Q
A
L
V
D
K
M
M
A
L
Q
T
D
S
V
D
L
Q
R
N
P
T
L
D
D
L
E
E
Q
A
R
D
L
Y
R
R
L
R
E
RPRDQRTPGDSND
M
V
R
L
L
I
L
A
I
Q
S
F
E
K
R
V
I
L
I
Y
D
Q
L
S
K
T
V
V
C
K
R
K
A
L
E
L
S
P
K
V
K
E
V
M
N
L
M
R
E
D
E
K
I
V
V
R
R
Q
E
K
R
Q
Q
E
L
W
N
L
L
K
I
A
C
S
K
V
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
65.41
26%
-16
- C1 -
-
4RED
-
AAPK1_HUMAN
A:
[12-317]
------------------------
S
V
K
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
-----
L
T
G
H
A
V
A
V
K
I
L
-
N
R
Q
-
K
I
R
S
L
------
D
V
V
G
K
I
R
R
E
I
Q
N
L
K
L
F
R
---
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
---
S
D
-
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
-
C
K
--------
N
G
R
---
L
D
E
K
E
S
--
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
--
H
M
---
N
A
K
I
A
D
F
G
L
S
N
M
M
S
D
----------------------------------------------
S
P
N
Y
A
A
P
E
V
I
S
G
-----
R
L
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
-
G
T
L
P
F
D
-
D
D
H
V
P
T
L
F
K
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-
F
Y
T
P
--
Q
Y
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
S
I
K
D
I
R
E
H
E
W
F
K
Q
D
L
P
K
Y
L
F
P
---
E
D
P
S
Y
S
T
T
M
I
D
D
E
A
L
K
E
V
C
E
--
K
F
E
C
S
E
E
E
V
L
S
C
L
Y
N
R
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
HHSearch
63.99
26%
-15
- C1 -
-
4RED
-
AAPK1_HUMAN
B:
[12-317]
------------------------
S
V
K
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
-----
L
T
G
H
A
V
A
V
K
I
L
-
N
R
Q
-
K
I
R
S
L
------
D
V
V
G
K
I
R
R
E
I
Q
N
L
K
L
F
R
---
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
---
S
D
-
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
-
C
K
--------
N
G
R
---
L
D
E
K
E
S
--
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
--
H
M
---
N
A
K
I
A
D
F
G
L
S
N
M
M
S
D
G
---------------------------------------------
S
P
N
Y
A
A
P
E
V
I
S
G
-----
R
L
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
-
G
T
L
P
F
D
-
D
D
H
V
P
T
L
F
K
K
I
C
D
-------------
G
----------------------------------------------------------------------------------------------------------------------------------------------------------
I
-
F
Y
T
P
--
Q
Y
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
S
I
K
D
I
R
E
H
E
W
F
K
Q
D
L
P
K
Y
L
F
P
---
E
D
P
S
Y
S
T
T
M
I
D
D
E
A
L
K
E
V
C
E
--
K
F
E
C
S
E
E
E
V
L
S
C
L
Y
N
R
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
61.90
30%
-100
- C1 -
-
4XBR
1
INKA1_HUMAN
A:
[93-294]
---------------------------
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
-----
S
S
G
K
L
V
A
V
K
K
M
-
D
L
R
-
K
Q
---------
Q
R
R
E
L
L
F
N
E
V
V
I
M
R
D
Y
Q
---
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
---
D
E
-
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
-
T
H
--------
T
-
R
---
M
N
E
E
Q
I
--
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
--
D
G
---
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
------------------------------------
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
R
------
L
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
-
G
E
P
P
Y
F
-
N
E
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
60.40
31%
-50
- C1 -
-
3Q53
1
A:
[23-223]
------------------------------
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
-----
A
T
G
Q
E
V
A
I
R
Q
M
-
N
L
Q
-
Q
Q
---------
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
---
P
N
I
V
N
Y
L
D
S
Y
L
V
G
---
D
E
-
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
-
T
E
--------
T
C
M
---
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
---
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
--
D
G
---
S
V
K
L
T
D
F
G
F
---------------
C
A
Q
I
T
P
E
Q
---------------------
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
-----
K
A
Y
G
P
K
V
-
D
I
W
S
L
G
I
M
A
I
E
M
I
E
-
G
E
P
P
Y
L
N
E
N
P
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
Fugue
60.23
21%
37
- C1 -
-
1KOB
1
?
A:
[23-374]
INDYDKFYEDIWKK
Y
V
P
Q
P
V
E
V
K
Q
G
S
V
Y
D
Y
Y
D
I
L
E
E
L
G
S
G
A
F
G
V
V
H
R
C
V
E
K
-----
A
T
G
R
V
F
V
A
K
F
I
-
N
T
P
-
Y
P
---------
L
D
K
Y
T
V
K
N
E
I
S
I
M
N
Q
L
H
H
---
P
K
L
I
N
L
H
D
A
F
E
D
K
---
Y
E
-
M
V
L
I
L
E
F
L
S
G
G
E
L
F
D
R
I
A
A
E
--------
D
Y
K
---
M
S
E
A
E
V
--
I
N
Y
M
R
Q
A
C
E
G
L
K
H
M
H
E
H
S
I
V
H
L
D
I
K
P
E
N
I
M
C
E
T
KK
A
S
---
S
V
K
I
I
D
F
G
L
A
T
K
L
N
P
D
E
I
-------------------------------------
V
K
V
T
T
A
T
A
E
F
A
A
P
E
I
V
D
R
------
E
P
V
G
F
Y
T
D
M
W
A
I
G
V
L
G
Y
V
L
L
S
-
G
L
S
P
F
A
-
G
E
D
D
L
E
T
L
Q
N
V
K
R
-------------
C
D
W
E
F
DEDAFSSVS
P
E
A
K
D
F
I
K
N
L
L
Q
K
----
E
------
P
R
K
R
L
T
V
H
-----
D
A
L
E
HPWLK
G
D
H
S
N
L
T
S
R
I
P
S
S
R
Y
N
K
I
R
Q
-
K
I
K
E
K
Y
A
D
W
P
A
P
Q
P
A
I
G
R
I
A
N
F
S
S
L
R
K
H
R
P
Q
E
Y
Q
I
Y
D
S
Y
F
D
R
K
E
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
Fugue
59.10
20%
-1
- C1 -
-
1TKI
-
TITIN_HUMAN
A:
[18-338]
------------------------
K
E
L
Y
E
K
Y
M
I
A
E
D
L
G
R
G
E
F
G
I
V
H
R
C
V
E
T
-----
S
S
K
K
T
Y
M
A
K
F
V
--
K
V
-
K
G
---------
T
D
Q
V
L
V
K
K
E
I
S
I
L
N
I
A
R
H
---
R
N
I
L
H
L
H
E
S
F
E
S
M
---
E
E
-
L
V
M
I
F
E
F
I
S
G
L
D
I
F
E
R
I
N
T
S
--------
A
F
E
---
L
N
E
R
E
I
--
V
S
Y
V
H
Q
V
C
E
A
L
Q
F
L
H
S
H
N
I
G
H
F
D
I
R
P
E
N
I
I
Y
Q
T
RR
S
S
---
T
I
K
I
I
E
F
G
Q
A
R
Q
L
K
P
-------------------------------------
G
D
N
F
R
L
L
F
T
A
P
E
Y
Y
A
P
E
V
H
Q
H
------
D
V
V
S
T
A
T
D
M
W
S
L
G
T
L
V
Y
V
L
L
S
-
G
I
N
P
F
L
-
A
E
T
N
Q
Q
I
I
E
N
I
M
N
-------------
A
E
Y
T
-------------------
F
D
E
E
----
A
FKEIS
I
E
A
M
D
F
V
D
R
L
LVKE
R
K
-------
S
R
M
T
A
S
E
A
L
Q
H
P
W
L
K
Q
K
I
E
R
V
S
T
K
V
I
R
T
L
K
H
R
R
Y
Y
H
T
L
I
K
K
D
L
N
M
V
V
S
A
A
R
I
S
C
-
G
G
A
I
R
S
Q
K
G
V
S
V
A
K
V
K
V
A
S
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
58.16
28%
-81
- C1 -
-
5K00
1
MELK_HUMAN
A:
[7-211]
---------------------------
L
K
Y
Y
E
L
H
E
T
I
G
T
G
--
A
K
V
K
L
A
C
H
I
-----
L
T
G
E
M
V
A
I
K
I
M
-
D
K
N
-
T
L
G--------
S
D
L
P
R
I
K
T
E
I
E
A
L
K
N
L
R
---
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
---
N
K
-
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
-
I
S
--------
Q
D
R
---
L
S
E
E
E
T
--
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
--
Y
H
---
K
L
K
L
I
D
F
G
L
C
A
K
P
------------------------------------------------
S
L
A
Y
A
A
P
E
L
I
Q
G
-----
K
S
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
-
G
F
L
P
F
D
-
D
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
Fugue
57.29
29%
3
- C1 -
-
1VR2
-
VGFR2_HUMAN
A:
[820-1168]
----------------L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
GIDKT
A
T
C
R
T
V
A
V
K
M
L
K
E
G
A
-
T
H
---------
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
--
L
N
V
V
N
L
L
G
A
C
T
K
P
---
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
-
R
S
K
RNEFVPY
K
D
F
---
L
T
L
E
H
L
--
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
--
K
N
---
V
V
K
I
C
D
F
D
------------------
A
--------------------------------
R
L
P
L
K
W
M
A
P
E
T
I
F
D
------
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
-
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
PDYTT
P
E
M
Y
Q
-------------------
T
M
L
D
C
W
HG
E
------
P
S
Q
R
P
T
F
S
-----
E
L
-------
V
E
H
L
G
N
L
L
Q
A
N
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
57.04
31%
-48
- C1 -
-
3FXZ
1
?
A:
[22-222]
------------------------------
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
-----
A
T
G
Q
E
V
A
I
R
Q
M
-
N
L
Q
-
Q
Q
---------
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
---
P
N
I
V
N
Y
L
D
S
Y
L
V
G
---
D
E
-
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
-
T
E
--------
T
C
M
---
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
---
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
--
D
G
---
S
V
K
L
T
D
F
G
F
---------------
C
A
Q
I
T
P
E
Q
---------------------
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
-----
K
A
Y
G
P
K
V
-
D
I
W
S
L
G
I
M
A
I
E
M
I
E
-
G
E
P
P
Y
L
N
E
N
P
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
57.03
31%
-46
- C1 -
-
4DAW
-
A:
[22-222]
------------------------------
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
-----
A
T
G
Q
E
V
A
I
R
Q
M
-
N
L
Q
-
Q
Q
---------
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
---
P
N
I
V
N
Y
L
D
S
Y
L
V
G
---
D
E
-
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
-
T
E
--------
T
C
M
---
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
---
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
--
D
G
---
S
V
K
L
T
D
F
G
F
---------------
C
A
Q
I
T
P
E
Q
---------------------
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
-----
K
A
Y
G
P
K
V
-
D
I
W
S
L
G
I
M
A
I
E
M
I
E
-
G
E
P
P
Y
L
N
E
N
P
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
56.97
29%
-105
- C1 -
-
5J5T
1
M4K3_HUMAN
A:
[2-210]
--------------------------
S
Q
E
D
F
E
L
I
Q
R
I
G
S
G
T
Y
G
D
V
Y
K
A
R
N
V
-----
N
T
G
E
L
A
A
I
K
V
I
-
K
L
E
-
P
G
---------
E
D
F
A
V
V
Q
Q
E
I
I
M
M
K
D
C
K
---
H
P
N
I
V
A
Y
F
G
S
Y
L
R
R
---
D
K
-
L
W
I
C
M
E
F
C
G
G
G
S
L
Q
D
I
Y
-
H
V
--------
T
G
P
---
L
S
E
L
Q
I
--
A
Y
V
S
R
E
T
L
Q
G
L
Y
Y
L
H
S
K
G
K
M
H
R
D
I
K
G
A
N
I
L
L
T
D
--
N
G
---
H
V
K
L
A
D
F
G
V
S
A
Q
I
T
A
T
I
------------------------------------
A
---
A
F
I
G
T
P
Y
W
M
A
P
E
V
A
A
V
ER---
K
G
G
Y
N
Q
L
C
D
L
W
A
V
G
I
T
A
I
E
L
A
E
-
L
Q
P
P
M
F
-
D
L
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
56.79
31%
-52
- C1 -
-
4O0R
1
A:
[22-222]
------------------------------
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
-----
A
T
G
Q
E
V
A
I
K
Q
M
-
N
L
Q
-
Q
Q
---------
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
---
P
N
I
V
N
Y
L
D
S
Y
L
V
G
---
D
E
-
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
-
T
E
--------
T
C
M
---
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
---
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
--
D
G
---
S
V
K
L
T
D
F
G
F
---------------
C
A
Q
I
T
P
E
Q
---------------------
S
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
-----
K
A
Y
G
P
K
V
-
D
I
W
S
L
G
I
M
A
I
E
M
I
E
-
G
E
P
P
Y
L
N
E
N
P
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
55.88
31%
-49
- C1 -
-
1YHV
-
?
A:
[270-470]
------------------------------
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
-----
A
T
G
Q
E
V
A
I
R
Q
M
-
N
L
Q
-
Q
Q
---------
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
---
P
N
I
V
N
Y
L
D
S
Y
L
V
G
---
D
E
-
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
-
T
E
--------
T
C
M
---
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
---
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
--
D
G
---
S
V
K
L
T
D
F
G
F
---------------
C
A
Q
I
T
P
E
Q
---------------------
S
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
-----
K
A
Y
G
P
K
V
-
D
I
W
S
L
G
I
M
A
I
E
M
I
E
-
G
E
P
P
Y
L
N
E
N
P
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
55.77
31%
-49
- C1 -
-
5KBQ
1
PAK1_HUMAN
A:
[17-217]
------------------------------
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
-----
A
T
G
Q
E
V
A
I
K
Q
M
-
N
L
Q
-
Q
Q
---------
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
---
P
N
I
V
N
Y
L
D
S
Y
L
V
G
---
D
E
-
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
-
T
E
--------
T
C
M
---
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
---
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
--
D
G
---
S
V
K
L
T
D
F
G
F
---------------
C
A
Q
I
T
P
E
Q
---------------------
S
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
-----
K
A
Y
G
P
K
V
-
D
I
W
S
L
G
I
M
A
I
E
M
I
E
-
G
E
P
P
Y
L
N
E
N
P
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
55.43
31%
-45
- C1 -
-
1YHW
-
PAK1_HUMAN
A:
[270-470]
------------------------------
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
-----
A
T
G
Q
E
V
A
I
R
Q
M
-
N
L
Q
-
Q
Q
---------
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
---
P
N
I
V
N
Y
L
D
S
Y
L
V
G
---
D
E
-
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
-
T
E
--------
T
C
M
---
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
---
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
--
D
G
---
S
V
K
L
T
D
F
G
F
---------------
C
A
Q
I
T
P
E
Q
---------------------
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
-----
K
A
Y
G
P
K
V
-
D
I
W
S
L
G
I
M
A
I
E
M
I
E
-
G
E
P
P
Y
L
N
E
N
P
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
55.18
31%
-50
- C1 -
-
3FY0
1
A:
[22-222]
------------------------------
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
-----
A
T
G
Q
E
V
A
I
R
Q
M
-
N
L
Q
-
Q
Q
---------
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
---
P
N
I
V
N
Y
L
D
S
Y
L
V
G
---
D
E
-
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
-
T
E
--------
T
C
M
---
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
---
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
--
D
G
---
S
V
K
L
T
D
F
G
F
---------------
C
A
Q
I
T
P
E
Q
---------------------
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
-----
K
A
Y
G
P
K
V
-
D
I
W
S
L
G
I
M
A
I
E
M
I
E
-
G
E
P
P
Y
L
N
E
N
P
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
55.01
31%
-50
- C1 -
-
4EQC
1
A:
[26-226]
------------------------------
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
-----
A
T
G
Q
E
V
A
I
R
Q
M
-
N
L
Q
-
Q
Q
---------
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
---
P
N
I
V
N
Y
L
D
S
Y
L
V
G
---
D
E
-
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
-
T
E
--------
T
C
M
---
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
---
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
--
D
G
---
S
V
K
L
T
D
F
G
F
---------------
C
A
Q
I
T
P
E
Q
---------------------
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
-----
K
A
Y
G
P
K
V
-
D
I
W
S
L
G
I
M
A
I
E
M
I
E
-
G
E
P
P
Y
L
N
E
N
P
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
54.79
31%
-53
- C1 -
-
5DEY
1
PAK1_HUMAN
A:
[22-222]
------------------------------
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
-----
A
T
G
Q
E
V
A
I
K
Q
M
-
N
L
Q
-
Q
Q
---------
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
---
P
N
I
V
N
Y
L
D
S
Y
L
V
G
---
D
E
-
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
-
T
E
--------
T
C
M
---
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
---
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
--
D
G
---
S
V
K
L
T
D
F
G
F
---------------
C
A
Q
I
T
P
E
Q
---------------------
S
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
-----
K
A
Y
G
P
K
V
-
D
I
W
S
L
G
I
M
A
I
E
M
I
E
-
G
E
P
P
Y
L
N
E
N
P
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
54.50
30%
12
- C1 -
-
2PHK
1
PHKG1_RABIT
A:
[2-219]
--------------------------
F
Y
E
N
Y
E
P
K
E
I
L
G
R
G
V
S
S
V
V
R
R
C
I
H
K
-----
P
T
C
K
E
Y
A
V
K
I
I
-
D
V
T
-
G
G
GSFS
A
E
E
V
Q
E
L
R
E
A
T
L
K
E
V
D
I
L
R
K
V
S
G
--
H
P
N
I
I
Q
L
K
D
T
Y
E
T
N
---
T
F
-
F
F
L
V
F
D
L
M
K
K
G
E
L
F
D
Y
L
-
T
E
--------
K
V
T
---
L
S
E
K
E
T
--
R
K
I
M
R
A
L
L
E
V
I
C
A
L
H
K
L
N
I
V
H
R
D
L
K
P
E
N
I
L
L
D
D
--
D
M
---
N
I
K
L
T
D
F
G
F
S
C
Q
L
D
P
G
-------------------------------------
E
K
L
R
E
V
C
G
T
P
S
Y
L
A
P
E
I
I
E
C
S
M
N
DN
H
P
G
Y
G
K
E
V
D
M
W
S
T
G
V
I
M
Y
T
L
L
A
-
G
S
P
P
F
W
-
H
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------