@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_21_0910: (2018-03-09 )
MEPNKASSARGHYVRLGKNADVIYNEADVIGRGQFGIVYRGLIPASGTVVAVKLLQNVPMVFTPTSEHASQHSRHADRHEGKGSHPAALSSAGPSSSSFAPPSKPRSPGCPSELAILYDVRADNCPNIVHVISTWNKVLKPPRNEASGAAGAAPRLVSSSSSCESRPSRIFVMVTEYCEGGDLQQFMKARGGALPAHVARSFTYQLCNALLTLKRRRIVHRDVKPANLLLTSADCEVATLKLADFGMAKAAPAPESHKAGPASASGGKDTGREARNEEDEPADAFSPLFHSEMGTPMYMSPERLALQPYGYKADVYSAGMVLLEMMRGSCVQVKWESQLRSEVPRTIWRELRQYPPDEVPAWLDLVQRMTAADPAQRYSVEDVLRHSWFHAKVGPPLPPLTFPLPETSEGGAERQPQETRLQAAATPAAGCTGSGSQSTAHAGADSLTAAAVGAPGAGGDEMAPRAPHRHNDPTVGAGGKGTSVPEPSASSSSDDGEAGEGTQQAIKVAAPSNKHRNSRLAEPSKWMVLGVCAEVDAVHNVANGAYTGPPKPALGAQGASPVTTTVSSAVTAEAFSLPPGCGPHIITNAVRSFVDVVYLYVLQDELDAARGLTLVSYLMELMQNGYAAYLKCLEYLGCSWRHTAAMNSCTLGGHRLVVREVNALYGVWRQLMARLHGAQAAYTARLPSRILDSAAAWRQRVLGASATTGDEAAGADEDEGAPAALSVEEPRDVDVSEASTSSEGDMMMSALPSVTSISNVVADTEAAEGARVPLLAAPPAPRIAEKLRV
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.-----......160.......170.......180.......--190--........200.......210.....--..220.......230.......240.......250.......260.......270.......280.......290.......300...------..-.-.310.......320......-.330.-......340.-....--------.---------------..----350.----.----.----......360.......370......-----.380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MEPNKASSARG
H
Y
V
R
LGKNA
D
V
I
YNEADVIGRGQ
F
G
I
V
Y
R
GLIPAS
G
T
V
V
A
V
K
L
L
QNV
P
M
V
FTP
T
S
E
H
A
S
Q
H
SRHADRHEGKGSHPAALSSAGPSSSSFAPPSKPRSPGCPS
E
L
A
I
L
Y
D
VRADNCPN
I
V
H
V
I
S
T
W
N
K
VLKPPRNEASGAAGAA-----PRLVSSSSSCESRP
S
R
I
F
V
M
V
T
EYCEGG
D
L
Q
Q
F
M
K
A--RG---GA
L
P
A
H
V
A
R
S
F
T
Y
Q
L
C
N
A
L
L
T
L
K
R
R
R
--
I
V
HRDVKPA
N
L
L
L
TSADC
E
V
A
T
L
K
L
ADFGMAKAAPAPESHKAGPASASGGKDTGREARNEEDEP
A
D
A
F
S
P
L
F
H
SEMGTPMYM
S
P
E
R
L
A
------LQ-P-YGYK
A
D
V
Y
S
A
G
M
V
L
L
E
M
MRG-
S
C
V
Q
V
-
K
W
E
S
Q
L
R
-
S
E-V
P
R
T
--------
I
---------------
W
R
----
E
--
L
----R----Q----YPPDE
V
P
A
W
L
D
L
V
Q
R
M
TAAD
P
A
Q
RY-----
S
V
E
D
V
L
R
H
S
WFHAKVGPPLPPLTFPLPETSEGGAERQ
P
Q
E
T
R
L
Q
AAATPAAGCTGSGSQSTAHAGADS
L
T
A
AAVGAPGAGGDEMAPRAPHRHNDPTVGAGGKGTSVPEPSASSSSDDGEAGEG
T
Q
Q
A
I
K
VAAPSNKHRNSRLAEPS
K
W
M
V
L
G
VCA
E
V
D
A
V
H
NVANGAYTGPPKPALGAQGASP
V
T
T
T
VSS
A
V
T
AEAFSLPPGC
G
P
H
I
I
T
N
A
V
R
S
F
V
D
V
V
Y
L
Y
V
LQ
D
E
L
D
AAR
G
L
T
L
V
S
Y
L
M
E
L
M
QN
G
Y
A
A
Y
L
K
C
L
E
Y
LGCSWRHTAAMNSCTLGG
H
R
L
V
V
R
E
V
N
A
L
Y
G
V
W
R
Q
L
M
A
R
LHGAQ
A
A
Y
T
AR
L
P
S
R
I
L
D
S
A
A
A
W
R
Q
R
V
LGASATTGDEAAGADEDEGAP
A
A
L
SVEEPRDVDVSEASTSSEG
D
M
M
M
S
ALP
S
V
T
S
I
S
N
V
VADTEAAEGARV
P
L
LAAPPA
P
R
I
A
E
K
LRV
24
HHSearch
71.97
28%
-63
- C1 -
-
3C0I
1
CSKP_HUMAN
A:
[23-294]
--------------------
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
S
---------------------------------------
P
G
L
S
T
E
D
L
K
R
E
A
S
I
C
H
M
L
---
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
-----------------------------------
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
--
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
--
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
E
-
N
S
A
P
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
S
G
-------------------------------
L
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
------
R
E
-
P
-
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
-
C
L
P
F
Y
-
G
T
K
E
R
L
F
-
E
G
-
I
I
K
G
--------
K
---------------
Y
K
----
M
--
N
----
P
----
R
----
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
-----
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
71.87
28%
-62
- C1 -
-
3C0G
1
CSKP_HUMAN
B:
[23-294]
--------------------
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
S
---------------------------------------
P
G
L
S
T
E
D
L
K
R
E
A
S
I
C
H
M
L
---
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
-----------------------------------
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
--
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
--
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
E
-
N
S
A
P
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
S
G
-------------------------------
L
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
------
R
E
-
P
-
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
-
C
L
P
F
Y
-
G
T
K
E
R
L
F
-
E
G
-
I
I
K
G
--------
K
---------------
Y
K
----
M
--
N
----
P
----
R
----
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
-----
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
HHSearch
71.79
29%
-89
- C1 -
-
2Y7J
1
PHKG2_HUMAN
C:
[94-364]
---------------------
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
V
T
A
E
R
L
S
P
------------------------------------
E
Q
L
E
E
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
A
--
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
-----------------------------------
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
--
K
----
V
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
--
I
V
H
R
D
L
K
P
E
N
I
L
L
D
D
N
----
M
Q
I
R
L
S
D
F
G
F
S
C
H
L
E
P
G
E
--------------------------------
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
CSMDET
H
P
-
G
-
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
-
S
P
P
F
W
-
H
R
R
Q
I
----
L
-
M
L
R
M
--------
I
---------------
M
E
----
G
--
Q
----
Y
QFSS
P
----
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
-----
T
A
E
Q
A
L
Q
H
P
F
F
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
70.95
29%
-53
- C1 -
-
1J1B
1
GSK3B_HUMAN
B:
[53-344]
--------------------
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
K
------------------------------------------------
R
F
K
N
R
E
L
Q
I
M
R
K
L
---
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
-----------------------------
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
---
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
--
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
---
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
--------------------------------
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
------
G
A
T
D
-
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
-
Q
P
I
F
P
-
G
D
S
G
V
D
Q
L
V
E
-
I
I
K
V
LGTPT
R
E
Q
I
R
E
M
NPNYTEFKFPQI
K
A
----
H
P
W
T
----
K
----
V
----
F
R
P
R
T
P
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
-----
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
70.18
24%
-86
* C1 *
-
4B4L
3
DAPK1_HUMAN
A:
[7-281]
---------------
R
Q
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
--------------------------------------
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
---
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
-----------------------------------
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
--
K
----
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
--
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
N
--------------------------------
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
E
-
P
-
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
-
A
S
P
F
L
-
G
D
T
K
Q
E
T
-
L
A
N
V
S
A
V
--------
N
---------------
Y
E
----
F
--
E
----
D
----
E
----
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
69.54
24%
-87
- C1 -
-
2X0G
-
DAPK1_HUMAN
A:
[6-278]
----------------
Q
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
--------------
R
------------------------
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
---
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
-----------------------------------
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
--
K
----
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
--
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
N
--------------------------------
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
E
-
P
-
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
-
A
S
P
F
L
-
G
D
T
K
Q
E
T
-
L
A
N
V
S
A
V
--------
N
---------------
Y
E
----
F
--
E
----
D
----
E
----
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
69.43
25%
-109
- C1 -
-
2QR8
-
A:
[19-284]
------------------
Q
F
T
D
G
Y
E
V
K
E
D
I
G
V
G
S
Y
S
V
C
K
R
C
I
H
K
A
T
N
M
E
F
A
V
K
I
I
D
K
S
K
R
------------------------------------------------
D
P
T
E
E
I
E
I
L
L
R
Y
--
G
Q
H
P
N
I
I
T
L
K
D
V
Y
D
D
-----------------------------------
G
K
Y
V
Y
V
V
T
E
L
M
K
G
G
E
L
L
D
K
I
L
R
--
Q
----
K
F
F
S
E
R
E
A
S
A
V
L
F
T
I
T
K
T
V
E
Y
L
H
A
Q
G
--
V
V
H
R
D
L
K
P
S
N
I
L
Y
V
D
E
S
G
N
P
E
S
I
R
I
C
D
F
G
F
A
K
Q
L
R
A
E
N
-------------------------------
G
L
L
M
T
P
C
Y
T
A
N
F
V
A
P
E
V
L
E
------
R
Q
-
G
-
Y
D
A
A
C
D
I
W
S
L
G
V
L
L
Y
T
M
L
T
G
-
Y
T
P
F
A
-
N
G
P
D
D
T
P
-
E
E
-
I
L
A
R
--------
I
---------------
G
S
----
G
--
K
FSLS
G
----
G
----
Y
W
N
S
V
S
D
T
A
K
D
L
V
S
K
M
L
H
V
D
P
H
Q
R
L
-----
T
A
A
L
V
L
R
H
P
W
I
V
H
W
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
68.80
26%
-120
- C- -
-
4OTD
-
PKN1_HUMAN
A:
[618-884]
--------------------
L
E
D
F
K
F
L
A
V
L
G
R
G
H
F
G
K
V
L
L
S
E
F
R
P
S
G
E
L
F
A
I
K
A
L
K
K
G
D
I
V
A
-----------------------------------------
R
D
E
V
E
S
L
M
C
E
K
R
I
L
A
A
V
T
S
A
G
H
P
F
L
V
N
L
F
G
C
F
Q
T
-----------------------------------
P
E
H
V
C
F
V
M
E
Y
S
A
G
G
D
L
M
L
H
I
H
S
-------
D
V
F
S
E
P
R
A
I
F
Y
S
A
C
V
V
L
G
L
Q
F
L
H
E
H
K
--
I
V
Y
R
D
L
K
L
D
N
L
L
L
D
T
E
----
G
Y
V
K
I
A
D
F
G
L
C
K
E
G
M
G
Y
G
-------------------------------
D
R
T
S
T
F
C
G
T
P
E
F
L
A
P
E
V
L
T
------
D
T
-
S
-
Y
T
R
A
V
D
W
W
G
L
G
V
L
L
Y
E
M
L
V
G
-
E
S
P
F
P
-
G
D
D
E
----
E
E
-
V
F
D
S
--------
I
---------------
V
N
----
D
--
E
----
V
----
R
----
Y
P
R
F
L
S
A
E
A
I
G
I
M
R
R
L
L
R
R
N
P
E
R
R
L
GSSE
R
D
A
E
D
V
K
K
Q
P
F
F
R
T
L
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
68.33
25%
-109
- C1 -
-
4XBR
1
INKA1_HUMAN (first)
A:
[93-350]
--------------------
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
Q
--------------------------------------------
Q
R
R
E
L
L
F
N
E
V
V
I
M
R
D
Y
---
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
-----------------------------------
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
--
T
-----
R
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
--
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
----
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
P
-------------------------------
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
------
R
L
-
P
-
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
-
E
P
P
Y
F
-
N
E
P
P
L
K
A
-
M
K
-
M
I
R
D
--------
N
---------------
L
P
----
P
--
R
----
L
----
K
----
N
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
-----
T
A
A
E
L
L
K
H
P
F
L
A
K
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
67.26
26%
-117
- C1 -
-
5K00
1
MELK_HUMAN
A:
[5-266]
------------------
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
--
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
N
T
L
G
-------------------------------------------
S
D
L
P
R
I
K
T
E
I
E
A
L
K
N
L
---
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
-----------------------------------
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
--
Q
----
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
--
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
----
H
K
L
K
L
I
D
F
G
L
C
A
K
P
-------------------------------------------
S
L
A
Y
A
A
P
E
L
I
Q
------
G
K
-
S
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
-
F
L
P
F
D
-
D
D
N
V
----
M
A
-
L
Y
K
K
--------
I
---------------
M
R
----
G
--
K
----
Y
----
D
----
V
P
K
W
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
W
I
M
Q
D
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
64.40
21%
-96
- C1 -
-
1KOB
1
?
A:
[51-312]
---------------------
D
Y
Y
D
I
L
E
E
L
G
S
G
A
F
G
V
V
H
R
C
V
E
K
A
T
G
R
V
F
V
A
K
F
I
N
T
P
Y
P
L
--------------------------------------------
D
K
Y
T
V
K
N
E
I
S
I
M
N
Q
L
---
H
H
P
K
L
I
N
L
H
D
A
F
E
D
-----------------------------------
K
Y
E
M
V
L
I
L
E
F
L
S
G
G
E
L
F
D
R
I
A
A
--
E
D
---
Y
K
M
S
E
A
E
V
I
N
Y
M
R
Q
A
C
E
G
L
K
H
M
H
E
H
S
--
I
V
H
L
D
I
K
P
E
N
I
M
C
E
T
K
K
--
A
S
S
V
K
I
I
D
F
G
L
A
T
K
L
N
P
D
E
--------------------------------
I
V
K
V
T
T
A
T
A
E
F
A
A
P
E
I
V
D
------
R
E
-
P
-
V
G
F
Y
T
D
M
W
A
I
G
V
L
G
Y
V
L
L
S
G
-
L
S
P
F
A
-
G
E
D
D
L
----
E
-
T
L
Q
N
--------
V
---------------
K
R
C
D
W
E
F
--
D
----
E
----
D
----
A
F
S
S
V
S
P
E
A
K
D
F
I
K
N
L
L
Q
K
E
P
R
K
R
L
-----
T
V
H
D
A
L
E
H
P
W
L
K
G
D
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
HHSearch
64.00
26%
-154
- C1 -
-
4JXF
2
PLK4_HUMAN
A:
[7-264]
---------------------
E
D
F
K
V
G
N
L
L
G
K
G
S
F
A
G
V
Y
R
A
E
S
I
H
T
G
L
E
V
A
I
K
M
I
D
K
K
A
M
Y
K
-----------------------------------------
A
G
M
V
Q
R
V
Q
N
E
V
K
I
H
C
Q
L
---
K
H
P
S
I
L
E
L
Y
N
Y
F
E
D
-----------------------------------
S
N
Y
V
Y
L
V
L
E
M
C
H
N
G
E
M
N
R
Y
L
K
N
--
R
V
---
K
P
F
S
E
N
E
A
R
H
F
M
H
Q
I
I
T
G
M
L
Y
L
H
S
H
G
--
I
L
H
R
D
L
T
L
S
N
L
L
L
T
R
N
----
M
N
I
K
I
A
D
F
G
L
A
T
Q
L
K
M
P
H
E
----------------------------------------------------------------
S
D
V
W
S
L
G
C
M
F
Y
T
L
L
I
G
-
R
P
P
F
-----
V
K
----
N
-
T
L
N
K
--------
V
---------------
V
L
----
A
--
D
----
Y
----
E
----
M
P
S
F
L
S
I
E
A
K
D
L
I
H
Q
L
L
R
R
N
P
A
D
R
L
-----
S
L
S
S
V
L
D
H
P
F
M
S
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
63.98
26%
-94
- C1 -
-
4NIF
-
KS6A1_HUMAN
A:
[7-270]
--------------------
S
D
G
Y
V
V
K
E
T
I
G
V
G
S
Y
S
E
C
K
R
C
V
H
K
A
T
N
M
E
Y
A
V
K
V
I
D
K
S
K
R
------------------------------------------------
D
P
S
E
E
I
E
I
L
L
R
Y
--
G
Q
H
P
N
I
I
T
L
K
D
V
Y
D
D
-----------------------------------
G
K
H
V
Y
L
V
T
E
L
M
R
G
G
E
L
L
D
K
I
L
R
--
Q
----
K
F
F
S
E
R
E
A
S
F
V
L
H
T
I
G
K
T
V
E
Y
L
H
S
Q
G
--
V
V
H
R
D
L
K
P
S
N
I
L
Y
V
D
E
S
G
N
P
E
C
L
R
I
C
D
F
G
F
A
K
Q
L
R
A
E
N
-------------------------------
G
L
L
M
T
P
C
Y
---
F
V
A
P
E
V
L
K
------
R
Q
-
G
-
Y
D
E
G
C
D
I
W
S
L
G
I
L
L
Y
T
M
L
A
G
-
Y
T
P
F
A
-
N
G
P
S
D
T
P
-
E
E
-
I
L
T
R
--------
I
---------------
G
S
----
G
--
K
----
F
----
T
LSGG
N
W
N
T
V
S
E
T
A
K
D
L
V
S
K
M
L
H
V
D
P
H
Q
R
L
-----
T
A
K
Q
V
L
Q
H
P
W
V
T
Q
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
62.70
23%
-89
- C1 -
-
1TKI
-
TITIN_HUMAN
A:
[19-281]
------------------
E
L
Y
E
K
Y
M
I
A
E
D
L
G
R
G
E
F
G
I
V
H
R
C
V
E
T
S
S
K
K
T
Y
M
A
K
F
V
K
V
K
G
T
---------------------------------------------
D
Q
V
L
V
K
K
E
I
S
I
L
N
I
A
---
R
H
R
N
I
L
H
L
H
E
S
F
E
S
-----------------------------------
M
E
E
L
V
M
I
F
E
F
I
S
G
L
D
I
F
E
R
I
N
T
--
S
A
---
F
E
L
N
E
R
E
I
V
S
Y
V
H
Q
V
C
E
A
L
Q
F
L
H
S
H
N
--
I
G
H
F
D
I
R
P
E
N
I
I
Y
Q
T
R
R
--
S
S
T
I
K
I
I
E
F
G
Q
A
R
Q
L
K
P
G
D
--------------------------------
N
F
R
L
L
F
T
A
P
E
Y
Y
A
P
E
V
H
Q
------
H
D
-
V
-
V
S
T
A
T
D
M
W
S
L
G
T
L
V
Y
V
L
L
S
G
-
I
N
P
F
L
-
A
E
T
N
Q
----
Q
-
I
I
E
N
--------
I
---------------
M
N
----
A
--
E
YTFD
E
----
E
----
A
F
K
E
I
S
I
E
A
M
D
F
V
D
R
L
L
V
K
E
R
K
S
R
M
-----
T
A
S
E
A
L
Q
H
P
W
L
K
Q
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
61.70
20%
-103
- C1 -
-
2X4F
4
MYLK4_HUMAN
A:
[89-350]
---------------------
Y
T
V
S
K
T
E
I
L
G
-----
Q
V
H
K
C
E
E
T
A
T
G
L
K
L
A
A
K
I
I
K
T
R
G
M
--------------------------------------------
K
D
K
E
E
V
K
N
E
I
S
V
M
N
Q
L
---
D
H
A
N
L
I
Q
L
Y
D
A
F
E
S
-----------------------------------
K
N
D
I
V
L
V
M
E
Y
V
D
G
G
E
L
F
D
R
I
I
D
--
E
S
---
Y
N
L
T
E
L
D
T
I
L
F
M
K
Q
I
C
E
G
I
R
H
M
H
Q
M
Y
--
I
L
H
L
D
L
K
P
E
N
I
L
C
V
N
R
D
--
A
K
Q
I
K
I
I
D
F
G
L
A
R
R
Y
K
P
R
E
--------------------------------
K
L
K
V
N
F
G
T
P
E
F
L
A
P
E
V
V
N
------
Y
D
-
F
-
V
S
F
P
T
D
M
W
S
V
G
V
I
A
Y
M
L
L
S
G
-
L
S
P
F
L
-
G
D
N
D
A
E
T
L
N
N
-
I
L
A
C
--------
R
---------------
W
D
----
L
--
E
----
D
----
E
----
E
F
Q
D
I
S
E
E
A
K
E
F
I
S
K
L
L
I
K
E
K
S
W
R
I
-----
S
A
S
E
A
L
K
H
P
W
L
S
D
H
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
61.33
26%
-35
- C1 -
-
5O2C
4
WNK3_HUMAN
A:
[18-289]
--------------
V
A
T
S
P
S
G
R
F
L
K
F
D
I
E
L
G
R
G
A
F
K
T
V
Y
K
G
L
D
T
E
T
W
V
E
V
A
W
C
E
L
Q
D
R
K
L
T
------------------------------------------
K
A
E
Q
Q
R
F
K
E
E
A
E
M
L
K
G
L
---
Q
H
P
N
I
V
R
F
Y
D
S
W
E
S
I
L
-------------------------------
K
G
K
K
C
I
V
L
V
T
E
L
M
T
S
G
T
L
K
T
Y
L
K
R
--
F
----
K
V
M
K
P
K
V
L
R
S
W
C
R
Q
I
L
K
G
L
Q
F
L
H
T
R
T
PP
I
I
H
R
D
L
K
C
D
N
I
F
I
T
G
P
T
---
G
S
V
K
I
G
D
L
G
L
A
T
L
M
R
T
S
---------------------------------
F
A
K
S
V
I
G
T
P
E
F
M
A
P
E
M
Y
E
-------
E
-
H
-
Y
D
E
S
V
D
V
Y
A
F
G
M
C
M
L
E
M
A
T
S
-
E
Y
P
Y
S
-
E
C
Q
N
A
---
A
Q
-
I
Y
R
K
--------
V
---------------
T
S
----
G
IK
P
----
A
----
S
----
F
N
K
V
T
D
P
E
V
K
E
I
I
E
G
C
I
R
Q
N
K
S
E
R
L
-----
S
I
R
D
L
L
N
H
A
F
F
A
E
D
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
60.65
25%
-73
- C1 -
-
5IU2
1
M3K8_HUMAN
B:
[71-326]
-------------------
L
T
Y
R
N
-
G
S
D
F
I
P
R
G
A
F
G
K
V
Y
L
A
Q
D
I
K
T
K
K
R
M
A
C
K
L
I
P
V
D
Q
F
-------------------------------------------------
K
P
S
D
V
E
I
Q
A
C
F
---
R
H
E
N
I
A
E
L
Y
G
A
V
L
W
-----------------------------------
G
E
T
V
H
L
F
M
E
A
G
E
G
G
S
V
L
E
K
L
E
S
--
C
----
G
P
M
R
E
F
E
I
I
W
V
T
K
H
V
L
K
G
L
D
F
L
H
S
K
K
--
V
I
H
H
D
I
K
P
S
N
I
V
F
M
S
T
-----
K
A
V
L
V
D
F
G
L
S
V
Q
M
T
E
D
V
-------------------------------
Y
F
P
K
D
L
R
G
T
E
I
Y
M
S
P
E
V
I
L
------
C
R
-
G
-
H
S
T
K
A
D
I
Y
S
L
G
A
T
L
I
H
M
Q
T
G
-
T
P
P
W
V
-
K
R
Y
P
R
S
A
-
Y
P
S
Y
L
Y
I
--------
I
H
K
Q
------------
A
P
----
P
--
L
----
E
----
D
----
I
A
D
D
C
S
P
G
M
R
E
L
I
E
A
S
L
E
R
N
P
N
H
R
P
-----
R
A
A
D
L
L
K
H
E
A
L
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
57.34
26%
0
- C- -
-
2WEL
7
KCC2D_HUMAN
A:
[3-271]
--------------------
T
D
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
K
L
S
------------------------------------------
A
R
D
H
Q
K
L
E
R
E
A
R
I
C
R
L
L
---
K
H
P
N
I
V
R
L
H
D
S
I
S
E
-----------------------------------
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
--
R
----
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
--
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
-
K
G
A
A
V
K
L
A
D
F
G
L
A
I
E
V
Q
G
D
Q
-------------------------------
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
------
K
D
-
P
-
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
-
Y
P
P
F
W
-
D
E
D
Q
H
----
R
-
L
Y
Q
Q
--------
I
---------------
K
A
----
G
--
A
YDFP
S
----
P
----
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
-----
T
A
S
E
A
L
K
H
P
W
I
C
Q
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
Fugue
56.78
15%
21
- C1 -
-
1KOB
1
?
A:
[23-374]
------------------------------------------------------------------------
I
N
D
Y
D
K
F
Y
E
D
I
W
K
K
Y
V
P
Q
P
V
E
V
K
Q
G
S
V
Y
D
Y
Y
D
I
L
E
E
L
G
S
G
A
F
G
V
V
H
R
C
V
E
K
A
-
T
G
R
V
F
V
A
K
F
I
N
T
P
Y
P
L
D
K
Y
T
V
K
N
E
I
S
I
M
N
Q
L
HH
P
K
L
I
N
L
H
D
A
F
E
D
K
Y
--
E
M
V
L
I
L
E
F
L
S
G
G
E
L
F
D
R
I
A
A
--
E
D
---
Y
K
M
S
E
A
E
V
I
N
Y
M
R
Q
A
C
E
G
L
K
H
M
H
E
H
S
--
I
V
H
L
D
I
K
P
E
N
I
M
C
E
T
K
K
--
A
S
S
V
K
I
I
D
F
G
L
A
T
K
L
N
P
D
E
I
--------------------------------
V
K
V
T
T
A
T
A
E
F
A
A
P
E
I
V
D
------
R
E
-
P
-
V
G
F
Y
T
D
M
W
A
I
G
V
L
G
Y
V
L
L
S
G
L
S
P
F
A
G
-
E
D
D
L
E
T
L
-
Q
N
-
V
K
R
C
--------
D
---------------
W
E
----
F
--
D
----
E
----
D
----
A
F
S
S
V
S
P
E
A
K
D
F
I
K
N
L
L
Q
K
E
P
R
K
R
L
-----
T
V
H
D
A
L
E
H
P
W
L
K
G
D
--
H
S
N
L
T
S
R
I
P
S
S
R
Y
N
K
I
R
Q
K
I
K
E
K
Y
A
D
W
P
A
P
Q
P
A
I
G
R
I
A
N
F
S
S
L
R
K
H
R
P
Q
E
Y
Q
I
Y
D
S
Y
F
D
R
K
E
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
55.31
24%
-79
- C1 -
-
5AUW
1
DAPK1_HUMAN
A:
[74-277]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
--
E
L
V
A
G
G
E
L
F
D
F
L
-
A
--
E
K
-----
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
--
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
--------
H
K
I
---------
D
F
G
N
E
F
K
N
-----------
I
F
----
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
E
-
P
-
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
-
A
S
P
F
L
G
D
T
K
Q
E
T
L
-
A
N
-
V
S
A
V
--------
N
---------------
Y
E
----
F
--
E
----
D
----
E
----
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
L
Q
H
P
W
I
K
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------