@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
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Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
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Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_21_1000: (2018-03-09 )
MMNDLPRWPRYRPIRVIGQGGFGTVYLCVDTEPTSTMYEQEVAVKAVSLGALSDEEVLMVMSEVSLLKNVGHPNIITYYDSFLYDDDESALSRKGGATLVPQADGDDIAAAGAGFRSQWLCLVTEYMDGGDLAALLRQYSGQELNSTKDVCEATSLSTVGTAAAARKRGRPSAAVTEDAAAGADQGEVSEGDWVSRSRLHRQRLATTLRAVPRPPMSTFPTTVTKATVMRWDGLDASVDQTWMSDASAAAMPTTPLGATDAEAADGAACGSRNGIQMPTAAASNAAVGSAATGAPHLTNVSVKNTVAAAGLASEPLEPQLPPPPNQLWVESFLITDIAKQCLDALAYLHALCIVHRDIKPSNIYLSKRDGTVKIGDFGVSKLLQPAEPFTMTFVGTPFYLCPELCMGDPYSFGADIWALGVVLYELYCLKLPFTSDNVLAQIYVITEGVYDTAALGTPHAFAESQQAVLETLYGPSFLHSERLLHSLVVSMVDKMLQVDPAERPSAEELLTGVFGAGSTSRCGSSAGLPLAPVAPTPVHRPLSTCALAHDSVSTPPQRGPSSFAVKPEGVAATTPQAPSNRLGPSASEQHARWAGSLVAAASSTLQQEQGASRVSLTAPGSRRSRERRDDVVDDFTGAHAPLAVRVKTSVGDILQGMPSAQRERLGNRAAAEERDEKEEVSRAMLPVASPKPTPSSALFHSTVKAGVGSDSANRQAALSPSLAGRERAEVAALPEKRRGSTVGAEPPSLELAEHTALQLLPAAPFPLELLYGGLVNIGDSAVNSTGATGEQRTVDDKASVSTPLGAQATQQASPLSSMLPADRPPAVRTHCDDDDALDHPIGAQTRSEFMALMENIPWLKNAEVFSSIPLSAGCDNVMLVERANRSSVSASGADGALSSATDNTAAGGSEERAEGAAPASKGSRTAPHQRQSQLPSPLRSPHSPATGTEDMQMSSNPLLPVCRAGVVSPTAPRIEVKTISGTTITMGGSRRPPSSRSPFQRGSAGAAEMADAESTQSVSQRRVSGGLTAASRQPPCIPAAPLRQRVSVTALPTTVLTSTPKPPASRPDEPQMTQDASGPACPSPSLQPRGDADRQPTAVTVASKGASASHPRLFSSSGLEPTVGNAASEARLRPFSAAQMRATAIASASGAAPPTPKAHSPGHCEGYSTTELEALLQAKLLTHYQRRQRQLGAQRTQHAAQEAAKAAARAKLKALYDEVFVSRLDPASSDAAYTAPYHSGGTIDGPSEVPDEFVARTDKRSRAASDSGDSGAHFPGDDAVAAPVARAATQLPALEADAWAKGAPVAVHLTKEAASPSPPSAPSPPSAPSPPSAPSPPSAPSSHGSPLPFSVDATARQAETEESVLRALSAVYSRPVEIPATTVPGTGTLMDDGDYGKDWLAATPAVRRIREAASLAVAVEHQCAAFRRGKEPARLCVAPPWRPPHDSRDVPGLWETSSAEEEADVSARGRLGCPAPASVREEVRWRWSAPPSDLDDTAGTTSEDEERGALLSSTASSSAVPSISTSPSSSSSALLASTSGANMLDAPGQTSKTPSITAAPEADVQQRLQSRKLVPSGGELGGGVIGSRRSPADAHAGGPRPSSLLGSPMYLELDSVDGGIRGGHTRDDGIHGVSLSMSSLADASAKATAAAGHEKDETDSASASSSSTTSTISSTSSASHSSASHSSRALSHPHRSKDEARHDVSSSSHDDGSSAQNSSSGSSSDDAPSSASQTASFSFHSFGGAASSTDANDDDAEPCAATKRADSDGDEDMSYTYTVQLDAVTGRRHFEYVCPVTVEVVGALPGGCRVVSAVAALRALDFAKAAPLSAMQVPPSEHCSMKQGSDGLAARVLTAEAPTDLSATPSPHEGGDDTAAANGGISSCPGQDKTFLFDGEYHTMWQEDGGFGAAAASPPTPSAPAPSSSLSSLPPDAGATVGFTAVPGKQQGHVPAANGMAPPEGSQSAREATLHSALPSTTNWQPDATARVAAASSSCVEDGNNDGNGATAHLRGRAASLHLSGETLARVAAPLRPSHVALGALSEETMAKAHAPLTHPSLADSDPTKVNTEMLPASKSASSNADGNQAMGFLCDRACTQGQTAVTPAQEIAAVMETTWWMRVPSSPSASSQGLGTSQQQHQLTGSPQYIHLPLSLALRPLRQRTRFVGLLWRLWVSLKVSEPALSRVLLHRRGGAPSPSPGCTFAEAFGDWVTGTTPARDTDTGECTEVDVSQQSSSETSTSLRLGRTITTTATTEASSNSDTAADSQVLPASGSLTAPSRPSPLKWGLYYVEARTWCAVQLRTDADWAVVRRKISEMGTMLPFVRLYLLLEEAEPASE
Atome Classification :
(23 SA)
.........10........20........30........40........50.-.------......60........70.........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.-------......280.......290.......300.......310..--------------------.....320.......330.......340.......350.--.......360.....-.---.370.........380.......390.......400....------...410.......420.......430.......440..-.....450......-------------.460.......470.......480.......490.......500-------..-----.....510.......520.......530........540.......550.......560.......570.......580.......590.......600.......610.......620-.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320......1330......1340......1350......1360......1370......1380......1390......1400......1410......1420......1430......1440......1450......1460......1470......1480......1490......1500......1510......1520......1530......1540......1550......1560......1570......1580......1590......1600......1610......1620......1630......1640......1650......1660......1670......1680......1690......1700......1710......1720......1730......1740......1750......1760......1770......1780......1790......1800......1810......1820......1830......1840......1850......1860......1870......1880......1890......1900......1910......1920......1930......1940......1950......1960......1970......1980......1990......2000......2010......2020......2030......2040......2050......2060......2070......2080......2090......2100......2110......2120......2130......2140......2150......2160......2170......2180......2190......2200......2210......2220......2230......2240......2250......2260......2270......2280......2290......2300......2310......2320......2330....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MMNDLPRWPRYR
P
I
R
V
I
GQGGF
G
T
V
Y
L
C
VDTEPT
S
T
M
Y
E
Q
E
V
A
V
K
A
V
S
LGAL-
S
------
D
E
E
V
L
M
V
M
S
E
V
S
L
L
K
NV-GHP
N
I
I
T
Y
Y
D
S
FLYDD
D
E
S
A
L
SRKGG
A
T
L
VPQADGDD
I
A
AAGAGF
R
S
Q
W
L
C
L
V
T
E
YMDG
G
D
L
A
A
L
L
R
Q
YSGQELN
S
T
K
D
V
C
E
ATSLSTV
G
T
A
A
A
A
RKRGRPSAAVTEDAAAGADQGEVSEGD
W
V
S
R
S
R
L
H
R
Q
R
L
A
T
T
L
RAVPRPPMSTFPTTV
T
K
A
T
V
M
R
WDGLDA
S
V
D
Q
T
W
MSDASAAAMPTTPLGATDAEAADGAACGSRN-------GIQMPTAAASNAAVGSAATGAPH
L
T
N
V
S
VKN
T
V
AAAGLASE--------------------PLEPQLPPP
P
N
Q
L
W
V
E
S
F
L
I
T
D
I
A
K
Q
C
L
D
A
L
A
Y
L
H
A
-
L
C
--
I
V
HRDIKPS
N
I
Y
L
SK-R---D
G
--
T
V
K
I
G
D
F
G
V
S
K
LLQPAE
P
F
T
M
T
F
VG
T
P
F
YL
C
P
E
L
CM------GDPYSF
G
A
D
I
W
A
L
G
V
V
L
Y
E
L
Y
C
L
KLPFTSDN
V
L
A
Q
I
Y
V
-
I
TEGVYDTAALGT
P
-------------
H
A
F
A
E
S
Q
Q
A
V
L
E
T
LYGP
S
F
L
H
S
E
R
L
L
H
S
L
V
V
S
M
V
D
K
M
L
QVDPAE-------RP-----
S
A
E
E
L
L
T
G
V
FGAGSTSRCGSSAGLPLA-PVAPTPVHR
P
L
S
T
C
A
LAHDSVSTPPQRGPSS
F
A
VKPEGVAATTPQAPSNRLGPSA
S
E
Q
H
A
R
W
A
G
S
L
V
A
A
A
S
S
T
L
Q
Q
E
QGA
S
R
V
S
L
TAPGSR-RS
R
E
R
R
D
D
V
V
D
DFTGAHA
P
L
A
V
R
V
KT
S
V
G
D
I
L
QGM
P
S
A
Q
R
E
RLGNRAAAEER
D
E
K
E
E
V
S
R
A
MLPVASPKPT
P
S
S
A
L
F
H
S
T
V
K
AGVGSDSANRQAALSPSLAGRE
R
A
E
V
AALPEKRRGSTVGAEPPS
L
E
L
A
E
H
T
A
L
QLLPAAPF
P
L
E
L
L
YG
G
L
VNIG
D
S
AVNSTGATGEQRTVDDKASVSTPLGAQATQQAS
P
L
S
S
MLPADRPPAVRTHCDDDDALDHPIG
A
Q
T
R
S
E
F
M
A
L
M
ENIPWLKN
A
E
V
F
SSIPLSAGCD
N
V
M
L
V
E
RANRSSVSASGADGALSSATDNTAAGG
S
E
E
RAEGAAPASKGSRTAP
H
Q
R
Q
SQLPSPLRSPHSPATGTEDMQMSSNP
L
L
P
V
CRAGVVSPTA
P
R
I
E
V
K
T
IS
G
T
T
I
T
MGGSRRPPSSRSPFQRGSAGAAEMADA
E
S
T
Q
S
V
S
Q
R
R
VSGGLTAASRQPPCI
P
A
A
P
L
R
Q
R
V
S
VTALPTTVLTSTPKPPASRPDEPQMTQDASGPACPSPSLQPRGDADRQP
T
A
V
T
V
ASKGASASH
P
R
LFSSSGLEPTVGNAASEARLRPF
S
A
A
Q
M
R
A
T
A
IASASGAAPPTPKAHSPGHCEGY
S
T
T
E
L
E
A
L
L
Q
A
K
L
L
T
H
Y
Q
R
R
Q
R
QL
G
A
Q
R
T
Q
H
A
A
Q
E
A
A
K
A
A
A
R
A
K
L
K
A
L
Y
D
E
V
F
V
S
RLDPASSDA
A
Y
TAPYHSGGTID
G
P
S
EV
P
D
E
F
V
A
R
TDKRSRAASDSGDSGAHFPGD
D
A
V
A
A
P
V
A
R
A
A
TQLPALEADAWAKGA
P
V
A
V
H
L
T
K
EAASPSPPSAPSPPSAPSPPSAPSPPSAPSSHGSPL
P
F
SVDATARQA
E
T
E
E
S
V
L
R
A
L
S
A
V
YSRPVEIPATTVPGTGTLMDDGDYG
K
D
W
L
AA
T
P
A
V
R
R
I
R
E
A
A
S
L
A
V
A
V
E
H
Q
C
A
A
F
RRGKEP
A
R
L
CVAPPWRPPHDSRDVPGLWETSSAEEEADVSARGRLGCPA
P
A
S
V
R
E
E
V
R
W
R
WSAPPSDLDDTAGTTS
E
D
E
E
R
G
A
L
LSSTASSSAVPSISTSPSSSS
S
A
L
L
ASTSGANMLDAPGQTSKTPSITAA
P
E
A
D
V
Q
Q
R
L
Q
SRKLVPSGGELGGGVIGSRRSPADAHAGGPR
P
S
S
LLGS
P
M
Y
L
E
L
DSVDGGIRGGHTRDDGIH
G
V
S
L
S
M
S
S
LADASAKATAAAGHEKDETDSASASSSS
T
T
S
T
ISSTSSASHSSASHSSRALSHPHRS
K
D
E
A
RHDVSSSSHDDGSSAQNSSSGSSSDDAPSSASQ
T
A
S
F
S
F
HSFGGAASSTDANDDDAEPCAATKRADSDGDEDM
S
Y
T
Y
T
V
Q
L
D
AVTGR
R
H
F
E
Y
VCP
V
T
V
E
V
V
GALPG
G
C
R
V
V
S
A
V
A
A
L
R
A
L
D
F
AKAAPLSAMQVPPSEHCSMKQGSDGL
A
A
R
V
L
TAEAPTDLSATPSPHEGGDDTAAANGGISSCPGQD
K
T
F
L
FDG
E
Y
H
T
M
W
QEDGGFGAAAASPPTPSAPAPSS
S
L
SSLPPDAGA
T
V
G
F
T
AVPGKQQGHVPAANGMAPPEGS
Q
S
A
R
E
A
T
L
H
SALPSTTNWQPDA
T
A
R
V
AAASS
S
C
VEDGNNDGNG
A
T
A
H
L
RG
R
A
A
S
L
H
LS
G
E
T
L
A
R
V
AAPLRP
S
H
V
A
LGAL
S
E
E
T
M
A
KAHAPLTHPSLADSDPTKVNTEMLPASKSASSNADG
N
Q
A
M
G
F
L
C
DRACTQGQTAVT
P
A
Q
E
I
A
A
V
M
ET
T
W
W
M
RVPSSPSASSQGLGTS
Q
Q
Q
HQLTGSP
Q
Y
I
H
L
P
L
S
L
A
L
R
P
L
R
Q
R
T
R
F
V
G
L
L
W
R
L
W
V
S
L
KVS
E
P
A
L
S
R
V
L
L
H
RRGGAPSPSPG
C
T
F
A
E
A
FGDWVTGTTPARDTDTGE
C
T
E
VDVSQQSSSETS
T
S
L
RLG
R
T
I
T
T
T
A
TTEASSNSDTAADSQVLPASGSLTAPSRPSP
L
K
W
G
L
Y
Y
V
E
A
R
T
W
C
A
V
Q
L
RTDA
D
W
A
V
V
R
R
K
I
S
E
MG
T
M
L
P
F
V
R
L
Y
L
L
L
EEAEPASE
49
Fugue
75.01
14%
-
- C1 -
-
3QA8
-
?
A:
[16-666]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
K
E
R
L
G
T
G
G
F
G
Y
V
L
R
W
I
H
QDTGEQ
V
A
I
K
Q
C
R
Q
E
L
S
P
K
N
R
E
R
W
C
L
E
I
Q
I
M
K
K
L
N
H
P
N
V
V
S
A
R
E
V
P
D
G
LQKLAPND
L
P
L
L
A
M
EYCEGG
D
L
R
K
Y
L
N
Q
F
E
N
C
C
G
L
K
E
G
P
I
R
T
L
L
S
D
I
S
S
A
L
R
Y
L
H
E
-
N
R
--
I
I
H
R
D
L
K
P
E
N
I
V
L
Q
P
-
G
---
P
Q
R
L
I
H
K
I
I
D
L
G
Y
A
K
E
L
D
Q
G
E
L
C
T
-
E
F
V
G
T
L
Q
Y
L
A
P
E
L
L
E
------
Q
K
K
Y
T
V
T
V
D
Y
W
S
F
G
T
L
A
F
E
C
I
T
G
F
R
P
F
L
P
N
W
Q
P
V
Q
W
H
G
-
K
V
R
I
V
V
Y
D
D
L
T
G
A
V
K
F
S
S
VLPTPNHLS
G
I
L
A
G
K
L
E
R
W
L
Q
C
M
L
M
W
H
Q
R
T
D
P
Q
N
P
N
V
G
C
F
Q
A
L
D
S
I
L
S
L
K
L
L
S
V
M
N
MVSG
R
V
-----
H
T
Y
P
V
T
E
N
E
N
L
Q
N
L
K
S
W
L
Q
Q
D
T
G
I
P
E
E
E
Q
E
L
L
Q
A
S
G
L
A
L
N
S
A
Q
P
L
T
Q
Y
V
I
D
C
T
V
G
D
L
I
F
L
F
D
N
R
K
I
S
L
P
A
H
P
E
S
V
S
I
V
L
Q
D
P
K
R
P
L
T
Y
T
H
L
R
R
V
W
G
Q
I
W
Q
T
I
R
A
L
K
E
D
C
A
R
L
L
Q
G
Q
R
T
S
M
V
N
L
L
R
Y
N
T
E
L
S
K
K
K
N
S
M
T
S
E
C
E
Q
L
K
A
K
L
D
F
F
R
S
S
I
Q
I
D
L
E
K
Y
S
E
Q
M
E
F
G
I
T
S
E
K
L
L
S
A
W
R
E
M
E
Q
A
V
E
L
C
G
R
E
R
E
V
Q
A
L
V
D
K
M
M
A
L
Q
T
D
S
V
D
L
Q
R
--
N
P
T
L
D
D
L
E
E
Q
A
R
D
L
Y
R
R
L
R
E
R
P
R
D
Q
R
T
P
G
D
S
N
D
M
V
R
L
L
I
L
A
I
Q
S
F
E
K
R
V
I
L
I
Y
D
Q
L
S
K
T
V
V
C
K
R
K
A
L
E
L
S
P
K
V
K
E
V
M
N
L
M
R
E
D
E
K
I
V
V
R
R
Q
E
K
R
Q
Q
E
L
W
N
L
L
K
I
A
C
S
K
V
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
68.40
30%
-91
- C1 -
-
3KK8
-
KCC2D_CAEEL
A:
[5-270]
-------
S
D
N
Y
D
V
K
E
E
L
G
K
G
A
F
S
V
V
R
R
C
V
H
K
T
T
G
L
-----
E
F
A
A
K
I
I
N
T
K
K
L
-
S
------
A
R
D
F
Q
K
L
E
R
E
A
R
I
C
R
K
L
-
Q
H
P
N
I
V
R
L
H
D
S
I
Q
E
E
--------------------------------
S
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
F
---------------------------------------------------
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
-------
A
D
A
S
H
C
I
Q
Q
I
L
E
S
I
A
Y
C
H
S
-
N
G
--
I
V
H
R
N
L
K
P
E
N
L
L
L
A
S
-
K
AK-
G
A
--
A
V
K
L
A
D
F
G
L
A
I
E
V
N
D
S
-
E
A
W
H
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
K
------
K
D
P
Y
S
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
H
R
L
Y
A
Q
-
I
K
A
G
A
Y
D
Y
------------------------------
P
S
-------
P
E
W
D
T
V
T
P
E
A
K
S
L
I
D
S
M
L
T
V
N
P
K
K
-------
R
I
-----
T
A
D
Q
A
L
K
V
P
W
I
C
N
R
E
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
66.76
30%
-88
- C1 -
-
2BDW
-
KCC2D_CAEEL
A:
[10-275]
-------
S
D
N
Y
D
V
K
E
E
L
G
K
G
A
F
S
V
V
R
R
C
V
H
K
T
T
G
L
-----
E
F
A
A
K
I
I
N
T
K
K
L
-
S
------
A
R
D
F
Q
K
L
E
R
E
A
R
I
C
R
K
L
-
Q
H
P
N
I
V
R
L
H
D
S
I
Q
E
E
--------------------------------
S
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
F
---------------------------------------------------
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
-------
A
D
A
S
H
C
I
Q
Q
I
L
E
S
I
A
Y
C
H
S
-
N
G
--
I
V
H
R
N
L
K
P
E
N
L
L
L
A
S
-
K
AK-
G
A
--
A
V
K
L
A
D
F
G
L
A
I
E
V
N
D
S
E
-
A
W
H
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
K
------
K
D
P
Y
S
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
H
R
L
Y
A
Q
-
I
K
A
G
A
Y
D
Y
------------------------------
P
S
-------
P
E
W
D
T
V
T
P
E
A
K
S
L
I
D
S
M
L
T
V
N
P
K
K
-------
R
I
-----
T
A
D
Q
A
L
K
V
P
W
I
C
N
R
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
65.24
29%
-139
- C1 -
-
4XBR
1
INKA1_HUMAN (first)
A:
[92-350]
------
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
-----
L
V
A
V
K
K
M
D
L
R
K
---------
Q
Q
R
R
E
L
L
F
N
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
--------------------------------
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
T
R
----------------------------------------------------
M
------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
-------
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
-
Q
G
--
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
-----
D
G
--
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
------
R
L
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
-
I
R
D
N
L
---------------------------------
P
P
R
-----
L
K
N
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
-------
R
A
-----
T
A
A
E
L
L
K
H
P
F
L
A
K
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
64.84
34%
-29
- C1 -
-
2Y7J
1
PHKG2_HUMAN
D:
[93-364]
-------
Y
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
-----
E
F
A
V
K
I
M
E
V
----
R
LSPEQL
E
E
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
--------------------------------
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
V
A
---------------------------------------------------
L
------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
-------
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
-
N
N
--
I
V
H
R
D
L
K
P
E
N
I
L
L
D
D
-----
N
M
--
Q
I
R
L
S
D
F
G
F
S
C
H
L
E
P
G
E
-
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
CSMDET
H
P
G
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
R
R
Q
I
L
M
L
R
M
-
I
M
E
G
Q
Y
Q
F
-----------------------------
S
S
--------
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
-------
R
L
-----
T
A
E
Q
A
L
Q
H
P
F
F
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
62.72
34%
-32
- C1 -
-
2Y7J
1
PHKG2_HUMAN
C:
[93-364]
-------
Y
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
-----
E
F
A
V
K
I
M
E
V
T
A
E
-
R
LSPEQL
E
E
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
--------------------------------
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
V
A
---------------------------------------------------
L
------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
-------
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
-
N
N
--
I
V
H
R
D
L
K
P
E
N
I
L
L
D
D
-----
N
M
--
Q
I
R
L
S
D
F
G
F
S
C
H
L
E
P
G
E
-
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
CSMDET
H
P
G
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
R
R
Q
I
L
M
L
R
M
-
I
M
E
G
Q
Y
Q
F
-----------------------------
S
S
--------
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
-------
R
L
-----
T
A
E
Q
A
L
Q
H
P
F
F
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
62.51
31%
-48
- C1 -
-
4GV1
5
AKT1_HUMAN
A:
[6-281]
------
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
T
G
R
-----
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
------
K
D
E
V
A
H
T
L
T
E
N
R
V
L
Q
N
S
-
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
--------------------------------
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
V
---------------------------------------------------
F
------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
-------
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
--
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
-----
D
G
--
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
A
T
M
K
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
------
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
E
K
L
F
E
L
-
I
L
M
E
E
I
------------------------------
R
F
P
-----------
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
-------
R
L
GGGS
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
61.38
30%
-68
- C1 -
-
5O2C
4
WNK3_HUMAN
A:
[22-290]
-----
P
S
G
R
F
L
K
F
D
I
E
L
G
R
G
A
F
K
T
V
Y
K
G
L
D
T
E
T
W
V
-----
E
V
A
W
C
E
L
Q
D
R
K
L
-
T
------
K
A
E
Q
Q
R
F
K
E
E
A
E
M
L
K
G
L
-
Q
H
P
N
I
V
R
F
Y
D
S
W
E
S
I
L
----------------------------
K
G
K
K
C
I
V
L
V
T
E
L
M
T
S
G
T
L
K
T
Y
L
K
R
F
K
V
---------------------------------------------------
M
------------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
-------
K
V
L
R
S
W
C
R
Q
I
L
K
G
L
Q
F
L
H
T
-
R
T
PP
I
I
H
R
D
L
K
C
D
N
I
F
I
T
G
-
P
---
T
G
--
S
V
K
I
G
D
L
G
L
A
T
L
M
R
T
S
--
F
A
K
S
V
I
G
T
P
E
F
M
A
P
E
M
Y
E
-------
E
H
Y
D
E
S
V
D
V
Y
A
F
G
M
C
M
L
E
M
A
T
S
E
Y
P
Y
S
E
C
Q
N
A
A
Q
I
Y
R
K
V
T
S
G
I
-
K
-------------------------------
P
A
-------
S
F
N
K
V
T
D
P
E
V
K
E
I
I
E
G
C
I
R
Q
N
K
S
E
-------
R
L
-----
S
I
R
D
L
L
N
H
A
F
F
A
E
D
T
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
60.34
28%
-55
- C1 -
-
3C0I
1
CSKP_HUMAN
A:
[20-296]
----
V
L
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
-----
Q
F
A
V
K
I
V
D
V
A
K
F
-
T
S
SP---
G
L
S
T
E
D
L
K
R
E
A
S
I
C
H
M
L
-
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
--------------------------------
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
A
-------------------------------------------------
G
F
----------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
S
E
-------
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
-
N
N
--
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
-
K
EN-
S
A
--
P
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
S
G
L
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
------
R
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
K
E
R
-
L
F
E
G
-
I
I
K
G
K
Y
K
M
-----------------------------
N
P
--------
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
-------
R
I
-----
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
R
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
60.02
28%
-52
- C1 -
-
3C0G
1
CSKP_HUMAN
B:
[21-296]
-----
L
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
-----
Q
F
A
V
K
I
V
D
V
A
K
F
-
T
S
SP---
G
L
S
T
E
D
L
K
R
E
A
S
I
C
H
M
L
-
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
--------------------------------
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
A
-------------------------------------------------
G
F
----------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
S
E
-------
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
-
N
N
--
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
-
K
EN-
S
A
--
P
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
S
G
L
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
------
R
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
K
E
R
-
L
F
E
G
-
I
I
K
G
K
Y
K
M
-----------------------------
N
P
--------
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
-------
R
I
-----
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
R
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
59.98
29%
0
- C- -
-
2WEL
7
KCC2D_HUMAN
A:
[3-271]
-------
T
D
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
-----
E
Y
A
A
K
I
I
N
T
K
K
L
-
S
------
A
R
D
H
Q
K
L
E
R
E
A
R
I
C
R
L
L
-
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
--------------------------------
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
---------------------------------------------------
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
-------
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
-
N
G
--
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
-
K
SK-
G
A
--
A
V
K
L
A
D
F
G
L
A
I
E
V
Q
G
D
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
------
K
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
H
R
L
Y
Q
Q
-
I
K
A
G
A
Y
D
F
------------------------------
P
S
-------
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
-------
R
I
-----
T
A
S
E
A
L
K
H
P
W
I
C
Q
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
59.68
27%
-101
* C1 *
-
1TKI
-
TITIN_HUMAN
A:
[20-284]
------
L
Y
E
K
Y
M
I
A
E
D
L
G
R
G
E
F
G
I
V
H
R
C
V
E
T
S
S
K
K
-----
T
Y
M
A
K
F
V
K
V
K
G
----------
T
D
Q
V
L
V
K
K
E
I
S
I
L
N
I
A
-
R
H
R
N
I
L
H
L
H
E
S
F
E
S
M
--------------------------------
E
E
L
V
M
I
F
E
F
I
S
G
L
D
I
F
E
R
I
N
T
S
A
F
--------------------------------------------------
E
L
------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
-------
R
E
I
V
S
Y
V
H
Q
V
C
E
A
L
Q
F
L
H
S
-
H
N
--
I
G
H
F
D
I
R
P
E
N
I
I
Y
Q
T
-
R
R--
S
S
--
T
I
K
I
I
E
F
G
Q
A
R
Q
L
K
P
G
D
-
N
F
R
L
L
F
T
A
P
E
Y
Y
A
P
E
V
H
Q
------
H
D
V
V
S
T
A
T
D
M
W
S
L
G
T
L
V
Y
V
L
L
S
G
I
N
P
F
L
A
E
T
N
Q
Q
I
I
E
N
-
I
M
N
A
E
Y
T
F
------------------------------
D
E
-------
E
A
F
K
E
I
S
I
E
A
M
D
F
V
D
R
L
L
V
K
E
R
K
S
-------
R
M
-----
T
A
S
E
A
L
Q
H
P
W
L
K
Q
K
I
E
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
59.60
29%
-89
- C1 -
-
5J5T
1
M4K3_HUMAN
A:
[3-270]
-------
Q
E
D
F
E
L
I
Q
R
I
G
S
G
T
Y
G
D
V
Y
K
A
R
N
V
N
T
G
E
-----
L
A
A
I
K
V
I
K
L
E
P
---------
G
E
D
F
A
V
V
Q
Q
E
I
I
M
M
K
D
C
-
K
H
P
N
I
V
A
Y
F
G
S
Y
L
R
R
--------------------------------
D
K
L
W
I
C
M
E
F
C
G
G
G
S
L
Q
D
I
Y
H
V
T
G
P
---------------------------------------------------
L
------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
-------
L
Q
I
A
Y
V
S
R
E
T
L
Q
G
L
Y
Y
L
H
S
-
K
G
--
K
M
H
R
D
I
K
G
A
N
I
L
L
T
D
-----
N
G
--
H
V
K
L
A
D
F
G
V
S
A
Q
I
T
A
T
I
A
---
A
F
I
G
T
P
Y
W
M
A
P
E
V
A
A
V
ER---
K
G
G
Y
N
Q
L
C
D
L
W
A
V
G
I
T
A
I
E
L
A
E
L
Q
P
P
M
F
D
L
H
P
M
R
A
L
F
L
-
M
T
K
S
N
F
Q
P
------------------------------
P
K
------
L
K
D
K
M
K
W
S
N
S
F
H
H
F
V
K
M
A
L
T
K
N
P
K
K
-------
R
P
-----
T
A
E
K
L
L
Q
H
P
F
V
T
Q
H
L
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
57.14
28%
-100
- C1 -
-
2X4F
4
MYLK4_HUMAN
A:
[87-351]
------
S
F
Y
T
V
S
K
T
E
I
L
G
-----
Q
V
H
K
C
E
E
T
A
T
G
L
-----
K
L
A
A
K
I
I
K
T
R
G
M
---------
K
D
K
E
E
V
K
N
E
I
S
V
M
N
Q
L
-
D
H
A
N
L
I
Q
L
Y
D
A
F
E
S
K
--------------------------------
N
D
I
V
L
V
M
E
Y
V
D
G
G
E
L
F
D
R
I
I
D
E
S
Y
--------------------------------------------------
N
L
------------------------------------------------------------------------------------------------------------------------------------------------------------
T
E
-------
L
D
T
I
L
F
M
K
Q
I
C
E
G
I
R
H
M
H
Q
-
M
Y
--
I
L
H
L
D
L
K
P
E
N
I
L
C
V
N
R
D
---
A
K
--
Q
I
K
I
I
D
F
G
L
A
R
R
Y
K
P
R
E
-
K
L
K
V
N
F
G
T
P
E
F
L
A
P
E
V
V
N
------
Y
D
F
V
S
F
P
T
D
M
W
S
V
G
V
I
A
Y
M
L
L
S
G
L
S
P
F
L
G
D
N
D
A
E
T
L
N
N
-
I
L
A
C
R
W
D
L
------------------------------
E
D
-------
E
E
F
Q
D
I
S
E
E
A
K
E
F
I
S
K
L
L
I
K
E
K
S
W
-------
R
I
-----
S
A
S
E
A
L
K
H
P
W
L
S
D
H
K
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
HHSearch
52.42
26%
-27
- C1 -
-
2X0G
-
DAPK1_HUMAN
A:
[9-280]
------
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
-----
Q
Y
A
A
K
F
I
K
K
R
R
T
-
K
SSRR--
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
-
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
--------------------------------
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
---------------------------------------------------
L
------------------------------------------------------------------------------------------------------------------------------------------------------------
T
E
-------
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
-
L
Q
--
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
-
R
NVP
K
P
--
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
N
-
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
A
N
-
V
S
A
V
N
Y
E
------------------------------
F
E
D
-------
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
-------
R
M
-----
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
D
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
48.57
31%
-157
- C1 -
-
1YHW
-
PAK1_HUMAN
A:
[366-520]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
Q
--
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
-----
D
G
--
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
------
R
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
-
I
-------
A
T
N
G
T
P
-------------
E
------------------
L
Q
N
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
D
M
D
V
E
K
-------
R
G
-----
S
A
K
E
L
L
Q
H
Q
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
47.35
30%
-171
- C1 -
-
4ZLO
2
PAK1_HUMAN
A:
[118-272]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
Q
--
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
-----
D
G
--
S
V
K
L
T
D
F
G
---------
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
------
R
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
-
I
-------
A
T
N
G
T
P
-------------
E
------------------
L
Q
N
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
-------
R
G
-----
S
A
K
E
L
L
Q
H
Q
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
46.84
30%
-156
- C1 -
-
4ZY5
1
PAK1_HUMAN
A:
[119-273]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
Q
--
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
-----
D
G
--
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
------
R
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
-
I
-------
A
T
N
G
T
P
-------------
E
------------------
L
Q
N
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
-------
R
G
-----
S
A
K
E
L
L
Q
H
Q
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
46.80
25%
-90
- C1 -
-
4JXF
2
PLK4_HUMAN
A:
[5-264]
------
K
I
E
D
F
K
V
G
N
L
L
G
K
G
S
F
A
G
V
Y
R
A
E
S
I
H
T
G
L
-----
E
V
A
I
K
M
I
D
K
K
A
M
-
Y
K
-----
A
G
M
V
Q
R
V
Q
N
E
V
K
I
H
C
Q
L
-
K
H
P
S
I
L
E
L
Y
N
Y
F
E
D
S
--------------------------------
N
Y
V
Y
L
V
L
E
M
C
H
N
G
E
M
N
R
Y
L
K
N
R
V
K
--------------------------------------------------
P
------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
E
-------
N
E
A
R
H
F
M
H
Q
I
I
T
G
M
L
Y
L
H
S
-
H
G
--
I
L
H
R
D
L
T
L
S
N
L
L
L
T
R
-----
N
M
--
N
I
K
I
A
D
F
G
L
A
T
Q
L
K
M
P
H
E
-------------------------------
S
D
V
W
S
L
G
C
M
F
Y
T
L
L
I
G
R
P
P
F
----
V
K
N
T
L
N
K
-
V
V
L
A
D
------------------------------
Y
E
M
-----------
P
S
F
L
S
I
E
A
K
D
L
I
H
Q
L
L
R
R
N
P
A
D
-------
R
L
-----
S
L
S
S
V
L
D
H
P
F
M
S
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
46.79
31%
-156
- C1 -
-
4ZJI
1
PAK1_HUMAN
A:
[120-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
Q
--
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
-----
D
G
--
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
------
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
------
R
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
-
I
-------
A
T
N
G
T
P
-------------
E
------------------
L
Q
N
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
-------
R
G
-----
S
A
K
E
L
L
Q
H
Q
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
31.08
43%
-186
- C1 -
-
5DZC
1
?
A:
[630-753]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
K
P
Q
A
Q
F
Y
L
G
S
I
I
L
---------
A
I
E
Y
L
H
E
-
R
N
--
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
K
-
Q
----
G
--
Y
V
K
L
I
D
F
G
C
A
K
K
I
Q
G
R
---
A
Y
T
L
V
G
T
P
H
Y
M
A
P
E
V
I
L
------
G
K
G
Y
G
C
T
V
D
I
W
A
L
G
V
C
L
Y
E
F
I
C
G
P
L
P
F
G
N
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
31.06
43%
-182
- C1 -
-
5F0A
1
?
A:
[630-761]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
K
P
Q
A
Q
F
Y
L
G
S
I
I
L
---------
A
I
E
Y
L
H
E
-
R
N
--
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
K
-
Q
----
G
--
Y
V
K
L
I
D
F
G
C
A
K
K
I
Q
G
R
---
A
Y
T
L
V
G
T
P
H
Y
M
A
P
E
V
I
L
------
G
K
G
Y
G
C
T
V
D
I
W
A
L
G
V
C
L
Y
E
F
I
C
G
P
L
P
F
G
N
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
28.23
43%
-180
- C1 -
-
5FET
1
?
A:
[630-733]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
K
P
Q
A
Q
F
Y
L
G
S
I
I
L
---------
A
I
E
Y
L
H
E
-
R
N
--
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
K
-
Q
----
G
--
Y
V
K
L
I
D
F
G
C
A
K
K
I
Q
G
R
---
A
Y
T
L
V
G
T
P
H
Y
M
A
P
E
V
I
L
------
G
K
G
Y
G
C
T
V
D
I
W
A
L
G
V
C
L
Y
E
F
I
C
G
P
L
P
F
G
N
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------