@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_21_1870: (2018-03-09 )
MEKYTQLKVLGKGSFGSAWLIQRNADRAQFVAKEVRLGGLKPAERESAQKEIDMLRTLNHPNITRYVDHFEHKGSLFIVMEYANGGDLYMRIKQQQGQLFSEKGILQCFSQICLALSYMHERRILHRDLKTQNVFLTKDGVVKVGDFGISTVLRNTYELKHTICGTPYYFSPELCLNKPYNNKSDVWALGCILYEMTTLNHAFDGSNMKALVQKILKGVYPPIHPMYSSNLSRLISSMLQIDPHKRPNVSQVLDLSFIREALAGLREEVQVARADRRSVVSVEERAHMQEAAARRKEEYRRKELEAAATLAKAQQQQQAILMQQQLEGEERRRNLVEQQRRLQRQQELALQERKRALDERVREQRKLQGQKSKVDAKAHHHREKQWDENMKEQVIEEQRRREAEEHHPRSDCQSPPQLQQERLQQQQEQSAAEAYREMRRQAAANKQRCYRESVFPGGAPCSQQRQQDESSAVPPGQPPPPRTPPSSSHYCSRKMTPEELEDARSQAFWQMRREAMDNRKKMLGHDVTDTGEPRAPTSAEAAPGASPASSNGKSASVASVPAPPQMSTLPPPSSAAAEETKPTKKSMSRKDKFTPESTGAQLPAPSPAPAVLLPPGAAAAAVPQEVDNGMTPDGEEGLHNFLNGEAAAASPTEAEDRRRDDDYNALDTVIGETLKADRKKNFKDDFDDAAFGEATDSSRLVLDGKTFHLPNVSATDPLMHRIESLRIFLEKEMGDDDLIKCYRAMNNISASDDEVMHQLQSALPPSKQRFIPLVAHLVVCEDAFNRQGASSSASASAIGL
Atome Classification :
(21 SA)
.........10........20........30........40.........50........60........70...--.....80........90...--.....100.......110.......120.--.......130.......140.......150.......160.......170.......180.......190.......200.......210.......--220---------------------------.........230.......240.....-----..250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MEK
Y
T
Q
L
K
V
L
GKGSFG
S
A
W
L
I
QRNA
D
R
A
Q
F
V
A
K
E
V
RLGGL-K
P
A
E
R
E
S
A
Q
K
E
I
D
M
L
R
TLNHP
N
I
T
R
Y
V
D
H
F
EHKG--
S
L
F
I
V
M
E
YANGG
D
L
Y
M
R
I
K
Q
--QQGQ
L
F
S
E
K
G
I
L
Q
C
F
S
Q
I
C
L
A
L
S
Y
M
H
E
-
R
--
R
I
L
H
R
DLKTQ
N
V
F
LTKD
G
V
V
K
VG
D
F
G
I
S
T
V
L
R
N
T
Y
E
L
K
HTICGTPYYF
S
P
E
L
CLNKPYNNKS
D
V
W
A
L
G
C
I
L
Y
E
M
TTLNHAFDGS
N
M
K
A
L
V
Q
K
I
L
K
G
V--Y-----------------------------PPI
H
P
M
Y
S
S
N
L
S
R
L
I
S
S
M
L
QIDPHKRP-----
N
V
S
Q
V
L
D
L
S
F
I
R
E
A
L
A
G
L
R
E
E
V
Q
V
A
R
ADRR
S
V
V
S
V
E
E
R
A
H
M
Q
E
A
A
A
R
R
K
E
E
Y
R
R
K
E
L
E
A
A
A
T
L
A
K
A
Q
Q
Q
Q
Q
A
I
L
M
Q
Q
Q
LE
G
E
E
R
R
R
N
L
V
E
Q
Q
R
R
L
Q
R
Q
Q
E
L
A
L
Q
E
R
K
R
A
L
D
E
R
V
R
E
Q
R
K
LQGQKSKV
D
A
K
A
H
H
H
R
E
K
Q
W
D
E
N
M
K
E
Q
V
I
E
E
Q
R
R
R
E
A
E
EHHPRSDCQSP
P
Q
L
Q
Q
E
R
L
Q
Q
Q
Q
E
Q
S
A
A
E
A
Y
R
E
M
R
R
Q
AAA
N
K
Q
R
C
Y
R
ESVFPGGAP
C
S
Q
Q
R
QQDESSAVPPGQPPPPRTPPSSSHYCSRKM
T
P
E
E
L
E
D
A
R
S
Q
A
F
W
Q
M
R
R
E
A
M
D
N
R
K
K
M
LGHDVTDTGEPRAPTSAEAAPGASPASSNGKSASVASVPAPPQMSTLPPPSSAAAEETK
P
T
K
K
SMSRKDKFTPESTGAQLPAPSPA
P
A
V
L
LPPGAAAAA
V
P
Q
E
VDNGMTPD
G
E
E
G
L
H
N
F
LNGEAAAASPT
E
A
E
DRRRDDD
Y
N
A
L
D
T
V
I
G
E
T
L
K
A
D
R
KKNFKDDFDDAAFGEATDS
S
R
L
V
LDG
K
T
F
HLPNVSAT
D
P
L
M
H
R
I
E
S
L
R
I
F
L
E
KEMG
D
D
D
L
I
K
C
Y
R
A
MNNISA
S
D
D
E
V
M
H
Q
L
Q
S
ALPPS
K
Q
R
F
I
P
L
V
A
H
L
V
V
C
E
D
A
FNRQGASSSASASAIGL
24
HHSearch
94.88
52%
-133
- C1 -
-
4B9D
2
NEK1_HUMAN
B:
[24-283]
-
E
K
Y
V
R
L
Q
K
I
G
-----
K
A
I
L
V
K
S
T
E
D
G
R
Q
Y
V
I
K
E
I
N
I
S
R
M
-
S
S
K
E
R
E
E
S
R
R
E
V
A
V
L
A
N
M
K
H
P
N
I
V
Q
Y
R
E
S
F
E
E
N
G
--
S
L
Y
I
V
M
D
Y
C
E
G
G
D
L
F
K
R
I
N
A
--
Q
K
G
V
L
F
Q
E
D
Q
I
L
D
W
F
V
Q
I
C
L
A
L
K
H
V
H
D
-
R
--
K
I
L
H
R
D
I
K
S
Q
N
I
F
L
T
K
D
G
T
V
Q
L
G
D
F
G
I
A
R
V
L
N
S
T
V
E
L
A
R
A
C
I
G
T
P
Y
Y
L
S
P
E
I
C
E
N
K
P
Y
N
N
K
S
D
I
W
A
L
G
C
V
L
Y
E
L
C
T
L
K
H
A
F
E
A
G
S
M
K
N
L
V
L
K
I
I
S
G
S
--
F
-----------------------------
P
P
V
S
L
H
Y
S
Y
D
L
R
S
L
V
S
Q
L
F
K
R
N
P
R
D
R
P
-----
S
V
N
S
I
L
E
K
G
F
I
A
K
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
94.47
52%
-131
- C1 -
-
4APC
-
NEK1_HUMAN
B:
[24-283]
-
E
K
Y
V
R
L
Q
K
I
G
-----
K
A
I
L
V
K
S
T
E
D
G
R
Q
Y
V
I
K
E
I
N
I
S
R
M
-
S
S
K
E
R
E
E
S
R
R
E
V
A
V
L
A
N
M
K
H
P
N
I
V
Q
Y
R
E
S
F
E
E
N
G
--
S
L
Y
I
V
M
D
Y
C
E
G
G
D
L
F
K
R
I
N
A
--
Q
K
G
V
L
F
Q
E
D
Q
I
L
D
W
F
V
Q
I
C
L
A
L
K
H
V
H
D
-
R
--
K
I
L
H
R
D
I
K
S
Q
N
I
F
L
T
K
D
G
T
V
Q
L
G
D
F
G
I
A
R
V
L
N
S
T
V
E
L
A
R
A
C
I
G
T
P
Y
Y
L
S
P
E
I
C
E
N
K
P
Y
N
N
K
S
D
I
W
A
L
G
C
V
L
Y
E
L
C
T
L
K
H
A
F
E
A
G
S
M
K
N
L
V
L
K
I
I
S
G
S
--
F
-----------------------------
P
P
V
S
L
H
Y
S
Y
D
L
R
S
L
V
S
Q
L
F
K
R
N
P
R
D
R
P
-----
S
V
N
S
I
L
E
K
G
F
I
A
K
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
92.63
52%
-136
- C1 -
-
4APC
-
NEK1_HUMAN
A:
[23-280]
M
E
K
Y
V
R
L
Q
K
I
------
K
A
I
L
V
K
S
T
E
D
G
R
Q
Y
V
I
K
E
I
N
I
S
R
M
-
S
S
K
E
R
E
E
S
R
R
E
V
A
V
L
A
N
M
K
H
P
N
I
V
Q
Y
R
E
S
F
E
E
N
G
--
S
L
Y
I
V
M
D
Y
C
E
G
G
D
L
F
K
R
I
N
A
--
Q
K
G
V
L
F
Q
E
D
Q
I
L
D
W
F
V
Q
I
C
L
A
L
K
H
V
H
D
-
R
--
K
I
L
H
R
D
I
K
S
Q
N
I
F
L
T
K
D
G
T
V
Q
L
G
D
F
G
I
A
R
V
L
N
S
T
V
E
L
A
R
A
C
I
G
T
P
Y
Y
L
S
P
E
I
C
E
N
K
P
Y
N
N
K
S
D
I
W
A
L
G
C
V
L
Y
E
L
C
T
L
K
H
A
F
E
A
G
S
M
K
N
L
V
L
K
I
I
S
G
S
--
F
-----------------------------
P
P
V
S
L
H
Y
S
Y
D
L
R
S
L
V
S
Q
L
F
K
R
N
P
R
D
R
P
-----
S
V
N
S
I
L
E
K
G
F
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
91.21
52%
-137
- C1 -
-
4B9D
1
NEK1_HUMAN
A:
[23-280]
M
E
K
Y
V
R
L
Q
K
I
------
K
A
I
L
V
K
S
T
E
D
G
R
Q
Y
V
I
K
E
I
N
I
S
R
M
-
S
S
K
E
R
E
E
S
R
R
E
V
A
V
L
A
N
M
K
H
P
N
I
V
Q
Y
R
E
S
F
E
E
N
G
--
S
L
Y
I
V
M
D
Y
C
E
G
G
D
L
F
K
R
I
N
A
--
Q
K
G
V
L
F
Q
E
D
Q
I
L
D
W
F
V
Q
I
C
L
A
L
K
H
V
H
D
-
R
--
K
I
L
H
R
D
I
K
S
Q
N
I
F
L
T
K
D
G
T
V
Q
L
G
D
F
G
I
A
R
V
L
N
S
T
V
E
L
A
R
A
C
I
G
T
P
Y
Y
L
S
P
E
I
C
E
N
K
P
Y
N
N
K
S
D
I
W
A
L
G
C
V
L
Y
E
L
C
T
L
K
H
A
F
E
A
G
S
M
K
N
L
V
L
K
I
I
S
G
S
--
F
-----------------------------
P
P
V
S
L
H
Y
S
Y
D
L
R
S
L
V
S
Q
L
F
K
R
N
P
R
D
R
P
-----
S
V
N
S
I
L
E
K
G
F
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
75.26
39%
-38
- C1 -
-
2W5A
5
NEK2_HUMAN
A:
[6-273]
-
E
D
Y
E
V
L
Y
T
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
-
T
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
NT
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
-
R
S---
L
H
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
N
V
K
L
G
D
F
G
L
A
R
I
L
---
T
S
F
A
K
T
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
M
-
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
--
F
-----------------------------
R
R
I
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
-----
S
V
E
E
I
L
E
N
P
L
I
L
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
72.70
39%
-40
- C1 -
-
2XNM
10
NEK2_HUMAN
A:
[6-273]
-
E
D
Y
E
V
L
Y
T
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
-
T
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
NT
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
-
R
------
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
N
V
K
L
G
D
F
G
L
A
R
I
L
---------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
-
S
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
--
F
-----------------------------
R
R
I
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
-----
S
V
E
E
I
L
E
N
P
L
I
L
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
71.58
39%
-45
- C1 -
-
2XKD
1
NEK2_HUMAN
A:
[6-273]
-
E
D
Y
E
V
L
Y
T
I
G
T
G
---
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
-
T
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
NT
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
-
R
SD------
L
K
P
A
N
V
F
L
D
G
K
Q
N
V
K
L
G
D
F
--------------
T
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
M
S
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
--
F
-----------------------------
R
R
I
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
-----
S
V
E
E
I
L
E
N
P
L
I
L
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
71.16
39%
-29
- C1 -
-
2XNO
13
NEK2_HUMAN
A:
[6-273]
-
E
D
Y
E
V
L
Y
T
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
-
T
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
NT
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
-
R
S-----
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
N
V
K
L
G
D
F
---------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
---
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
--
F
-----------------------------
R
R
I
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
-----
S
V
E
E
I
L
E
N
P
L
I
L
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
70.89
39%
-38
- C1 -
-
2XNP
6
NEK2_HUMAN
A:
[6-273]
-
E
D
Y
E
V
L
Y
T
I
G
T
G
-
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
-
T
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
NT
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
-
R
S----
H
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
N
V
K
L
G
D
F
G
L
-------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
---
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
--
F
-----------------------------
R
R
I
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
-----
S
V
E
E
I
L
E
N
P
L
I
L
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
70.57
39%
-31
- C1 -
-
2XNN
7
NEK2_HUMAN
A:
[6-273]
-
E
D
Y
E
V
L
Y
T
I
G
T
--
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
-
T
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
NT
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
-
R
S-----
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
N
V
K
L
G
D
F
G
--------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
--
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
--
F
-----------------------------
R
R
I
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
-----
S
V
E
E
I
L
E
N
P
L
I
L
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
69.89
39%
-32
- C1 -
-
2XKF
1
NEK2_HUMAN
A:
[6-273]
-
E
D
Y
E
V
L
Y
T
I
G
T
G
---
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
-
T
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
NT
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
-
R
S-----
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
N
V
K
L
G
D
F
---------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
-
S
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
--
F
-----------------------------
R
R
I
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
-----
S
V
E
E
I
L
E
N
P
L
I
L
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
69.41
39%
-35
- C1 -
-
2XKE
1
NEK2_HUMAN
A:
[6-273]
-
E
D
Y
E
V
L
Y
T
I
G
T
G
---
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
-
T
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
NT
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
-
R
SD------
L
K
P
A
N
V
F
L
D
G
K
Q
N
V
K
L
G
D
F
------------------
T
P
Y
Y
M
S
P
E
Q
M
N
----
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
--
F
-----------------------------
R
R
I
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
-----
S
V
E
E
I
L
E
N
P
L
I
L
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
68.86
39%
-34
- C1 -
-
2XK4
1
NEK2_HUMAN
A:
[6-273]
-
E
D
Y
E
V
L
Y
T
I
G
T
--
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
-
T
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
NT
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
-
R
S-----
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
N
V
K
L
G
D
F
G
L
-------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
M
--
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
--
F
-----------------------------
R
R
I
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
-----
S
V
E
E
I
L
E
N
P
L
I
L
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
68.53
39%
-28
- C1 -
-
2XK7
1
NEK2_HUMAN
A:
[6-273]
-
E
D
Y
E
V
L
Y
T
I
G
T
G
---
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
-
T
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
NT
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
-
R
S-----
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
N
V
K
L
G
D
F
----------------
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
----
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
--
F
-----------------------------
R
R
I
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
-----
S
V
E
E
I
L
E
N
P
L
I
L
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
68.31
39%
-24
- C1 -
-
2XK6
1
NEK2_HUMAN
A:
[6-273]
-
E
D
Y
E
V
L
Y
T
I
G
-----
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
-
T
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
NT
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
-
R
S-----
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
N
V
K
L
G
D
-----------------
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
---
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
--
F
-----------------------------
R
R
I
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
-----
S
V
E
E
I
L
E
N
P
L
I
L
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
67.98
39%
-25
- C1 -
-
2XK3
1
NEK2_HUMAN
A:
[6-273]
-
E
D
Y
E
V
L
Y
T
I
G
T
----
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
-
T
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
NT
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
-
R
S-----
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
N
V
K
L
G
D
F
G
---------------
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
---
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
--
F
-----------------------------
R
R
I
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
-----
S
V
E
E
I
L
E
N
P
L
I
L
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
67.57
39%
-27
- C1 -
-
2WQO
1
NEK2_HUMAN
A:
[6-273]
-
E
D
Y
E
V
L
Y
T
I
G
T
G
---
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
-
T
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
NT
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
-
R
--------
L
K
P
A
N
V
F
L
D
G
K
Q
N
V
K
L
G
D
------------------
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
---
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
--
F
-----------------------------
R
R
I
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
-----
S
V
E
E
I
L
E
N
P
L
I
L
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
67.26
39%
-30
- C1 -
-
2XKC
1
NEK2_HUMAN
A:
[6-273]
-
E
D
Y
E
V
L
Y
T
I
G
T
--
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
-
T
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
NT
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
-
R
S-------
L
K
P
A
N
V
F
L
D
G
K
Q
N
V
K
L
G
D
------------------
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
---
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
--
F
-----------------------------
R
R
I
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
-----
S
V
E
E
I
L
E
N
P
L
I
L
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
66.88
39%
-30
- C1 -
-
2XK8
1
NEK2_HUMAN
A:
[6-273]
-
E
D
Y
E
V
L
Y
T
I
G
T
----
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
-
T
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
NT
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
-
R
S-----
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
N
V
K
L
G
D
F
---------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
----
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
--
F
-----------------------------
R
R
I
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
-----
S
V
E
E
I
L
E
N
P
L
I
L
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
65.58
26%
-91
- C1 -
-
4BGQ
3
CDKL5_HUMAN
A:
[12-301]
-
N
K
F
E
I
L
G
V
V
G
E
G
A
Y
G
V
V
L
K
C
R
H
K
E
T
H
E
I
V
A
I
K
K
F
K
--------
V
K
E
T
T
L
R
E
L
K
M
L
R
T
L
K
Q
E
N
I
V
E
L
K
E
A
F
R
R
R
G
--
K
L
Y
L
V
F
E
Y
V
E
K
N
M
L
E
L
L
E
E
M
--
P
--
N
G
V
P
P
E
K
V
K
S
Y
I
Y
Q
L
I
K
A
I
H
W
C
H
K
-
N
--
D
I
V
H
R
D
I
K
P
E
N
L
L
I
S
H
N
D
V
L
K
L
C
D
F
G
F
A
R
N
L
S
E
----------
T
R
W
Y
R
S
P
E
L
L
L
G
A
P
Y
G
K
S
V
D
M
W
S
V
G
C
I
L
G
E
L
S
D
G
Q
P
L
F
P
G
E
S
E
I
D
Q
L
F
T
I
Q
K
V
L
GP
L
P
S
E
Q
M
K
L
F
Y
S
NPRFHGLRFPAV
N
H
P
Q
S
L
E
R
R
Y
L
G
I
L
N
S
V
L
L
D
L
M
K
N
L
L
K
L
D
P
A
D
R
Y
-----
L
T
E
Q
C
L
N
H
P
T
F
Q
T
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
57.72
30%
-17
- C1 -
-
4GV1
5
AKT1_HUMAN
A:
[8-276]
-
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
T
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
K
D
E
V
A
H
T
L
T
E
N
R
V
L
Q
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
--
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
--
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
--
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
A
T
M
K
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
E
K
L
F
E
L
I
L
M
E
E
--
I
------------------------------
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
GGGS
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------