@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_21_2010: (2018-03-10 )
MPTSSGVDQAKLREVIRVLKSVGHVGMAESLEVEWGMRPNTASHAKNAKKGRKSQPHKSRESSKARGNSFPSLSSIAVAPSPLQVTSQRRFVVTCIGDEEDLWSPDEDPADAKCCIAPLFDYGAGLLRDHYVEYAAHPVSLVSVHPYEKQQPPSNLPWRHFELKVFYEAGKTGSEEKKEFELVKGYLIGGRYRVDAPIDAATFSRTVRCYDEQTGQPVCLKIIRNSKTFLDQGLDELRALTCVNDAGDADACCVVRLLDYFYFREHLVLVTELLFDNLYEYVRKLDIVERCAYFTLARLQRIVRQVLTALKLIHSVNLIHCDIKPENIAFKSVADCDVKVLDLGSSCYMTDTLSSYVQSRSYRAPEVILGCKYGPAVDIWSLGATAAELATGTVLFNVESVPTMLASIASVCGPIPAEMLQEGRNTSLYVTKHGAFYDYEDEQLVFHFPSEPPDAAVLFGFDDHDYVGFVRLCLTLDAALRPSAAQLLDHPFLTKTYTD
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210........220.......230.......240.....--..250.......260.----......270.......280.......290.......300.......310.--..--.-...320.......330.-----------------------.---------------------------.....340.......350.......360.......370.......380.......390.......400-----........410.......420....--...430..-----...-----..440----..----------...-....450------.------.-..----....460.......470.......480.......490.......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MPTSSGV
D
Q
A
K
L
R
E
V
I
R
V
L
K
SVGHVGMA
E
S
L
E
V
E
WGMRPNT
A
S
H
A
K
N
AKKGRKSQPHKSRESSKARGNSFPSLSSIAVAPSP
L
Q
VTSQR
R
F
V
V
T
C
IG
D
E
E
DLWSPDEDPADAKC
C
I
A
P
L
F
D
Y
G
A
G
L
L
R
D
H
Y
V
E
YAAH
P
V
S
L
V
S
VHPYEKQQPPSNLP
W
R
H
F
E
L
K
V
F
Y
EAGKTG
S
E
E
K
K
E
F
E
L
V
K
G
Y
L
IG
G
R
Y
R
VDAPI
D
A
A
T
F
S
R
T
V
R
C
YD-EQTG
Q
P
V
C
L
K
I
IRN
S
K
T
F
L
D
Q
G
L
D
E
L
R
A
L
TCVNDAG--
D
A
D
A
C
C
V
V
R
L
L
D
Y
F
Y
F
----
R
E
H
L
V
L
V
T
E
L
L
F
D
N
L
Y
E
Y
V
R
K
L
D
I
V
E
R
C
A
Y
F
T
L
A
R
L
Q
R
I
V
R
Q
V
L
T
A
L
K
L
I
--HS--V-
N
L
I
H
CDIKPEN
I
A
F
K
SV-----------------------A---------------------------DC
D
V
K
V
L
DLGSSCY
M
T
D
T
L
S
S
Y
V
Q
SRSYRAP
E
V
I
L
GCKYGPAVDIWSLG
A
T
A
A
ELA
T
G
T
V
L
F
NV
E
S
V
------
P
T
M
L
A
S
I
A
S
V
CGPI
P
A
E
M
L
QEGRN
T
--
S
L
Y
V
T
KHG-----
A
F
Y-----DYE------D
E
----------
Q
L
V
-
F
HFPSE-------P------P-D
A
----
A
V
L
F
GFDDH
D
Y
V
G
F
V
R
L
C
L
T
LDAALR
P
S
A
A
Q
L
LDHPFLTKTYTD
21
HHSearch
95.75
35%
-122
- C1 -
-
4AZF
2
DYRK2_HUMAN
A:
[92-413]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
H
K
V
H
Q
H
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
--
K
D
N
T
M
N
V
I
H
M
L
E
N
F
T
F
----
R
N
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
K
----
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
--
H
K
--
N
-
R
I
I
H
C
D
L
K
P
E
N
I
L
L
K
Q
Q
-----------------------
G
---------------------------
R
S
G
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
R
V
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
------
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
D
A
S
K
R
A
--
K
N
F
V
S
S
K
G
-----
Y
P
R
Y
C
T
V
T
T
L
S
------
D
-
V
V
L
N
G
G
RSR-
R
G
K
-
L
R
G
P
P
E
-------
S
------
R
E
W
G
----
N
A
L
K
G
C
D
D
P
L
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
-----
22
HHSearch
92.33
36%
-114
- C1 -
-
5LXC
9
DYRK2_HUMAN
A:
[69-392]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
H
K
V
H
Q
H
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
--
K
D
N
T
M
N
V
I
H
M
L
E
N
F
T
F
----
R
N
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
K
----
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
--
H
K
--
N
-
R
I
I
H
C
D
L
K
P
E
N
I
L
L
K
Q
Q
-----------------------
G
---------------------------
R
S
G
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
R
V
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
------
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
D
A
S
K
R
A
--
K
N
F
V
S
S
K
G
-----
Y
P
------
R
Y
C
T
V
T
T
LS
D
G
S
V
V
L
N
G
G
R
SR
R
G
K
-
L
R
G
P
P
E
S------
R
------
E
-
W
G
----
N
A
L
K
G
C
D
D
P
L
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
-----
33
HHSearch
87.88
31%
-91
- C1 -
-
4YLL
10
DYR1A_HUMAN
A:
[22-357]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
I
V
K
N
G
E
K
W
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
V
E
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
--
T
E
-
K
Y
Y
I
V
H
L
K
R
H
F
M
F
----
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
----
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
P
E
--
L
-
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
P
-----------------------
K
---------------------------
R
S
A
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
------
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
P
K
A
--
R
K
F
F
E
K
L
P
D
G
---
T
W
N
L
K---
K
----------EYKPPGTR--
K
L
H
-
N
I
L
G
V
E
TGGPGG-
R
------
R
A
G
E
----
S
G
H
T
V
A
D
Y
L
K
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
----
30
HHSearch
87.86
31%
-82
* C1 *
-
4YU2
2
DYR1A_HUMAN
A:
[22-358]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
I
V
K
N
G
E
K
W
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
V
E
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
--
T
E
M
K
Y
Y
I
V
H
L
K
R
H
F
M
F
----
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
----
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
P
E
--
L
-
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
P
-----------------------
K
---------------------------
R
S
A
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
------
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
P
K
A
--
R
K
F
F
E
K
L
P
D
G
---
T
W
N
L
K---
K
T
K
------
D
G
KREYKPPGTR
K
L
H
-
N
I
L
G
V
E
-------
T
GGPGGR
R
A
G
E
----
S
G
H
T
V
A
D
Y
L
K
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
T
---
5
PsiBlast_PDB
86.24
33%
-101
- C1 -
-
3K2L
-
DYRK2_HUMAN
A:
[98-414]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
H
K
V
H
Q
H
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
--
K
D
N
T
M
N
V
I
H
M
L
E
N
F
T
F
----
R
N
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
----
N
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
--
H
K
--
N
-
R
I
I
H
C
D
L
K
P
E
N
I
L
L
K
Q
Q
-----------------------
G
---------------------------
R
S
G
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
R
V
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
------
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
D
A
S
K
R
A
--
K
N
F
V
S
S
K
G
Y
P
R
Y
C
T
V
T
-----
T
L
S
------
D
G
----------
S
V
V
-
L
N
G
G
R
S
R
R
G
K
LRG
P
------
P
-
E
S
R
E
WG
N
A
L
K
G
C
D
D
P
L
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
R
----
4
PsiBlast_PDB
85.90
33%
-110
- C1 -
-
4AZF
2
DYRK2_HUMAN
A:
[98-413]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
H
K
V
H
Q
H
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
--
K
D
N
T
M
N
V
I
H
M
L
E
N
F
T
F
----
R
N
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
----
N
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
--
H
K
--
N
-
R
I
I
H
C
D
L
K
P
E
N
I
L
L
K
Q
Q
-----------------------
G
---------------------------
R
S
G
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
R
V
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
------
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
D
A
S
K
R
A
--
K
N
F
V
S
S
K
G
YP
R
Y
C
T
V
T
-----
T
L
S
------
D
------------
V
V
-
L
N
G
G
R
S
R
R
G
K
L
R
G
P
------
P
-
E
S
R
E
W
G
N
A
L
K
G
C
D
D
P
L
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
-----
2
PsiBlast_PDB
85.68
33%
-103
- C1 -
-
5LXD
6
DYRK2_HUMAN
A:
[77-393]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
H
K
V
H
Q
H
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
--
K
D
N
T
M
N
V
I
H
M
L
E
N
F
T
F
----
R
N
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
----
N
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
--
H
K
--
N
-
R
I
I
H
C
D
L
K
P
E
N
I
L
L
K
Q
Q
-----------------------
G
---------------------------
R
S
G
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
R
V
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
------
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
D
A
S
K
R
A
--
K
N
F
V
S
S
K
G
YPR
Y
C
T
V
T
-----
T
L
S
------
D
G
----------
S
V
V
-
L
N
G
G
R
S
RR
G
K
L
R
G
P
------
P
-
E
S
R
E
W
G
N
A
L
K
G
C
D
D
P
L
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
R
----
3
PsiBlast_PDB
84.94
33%
-107
- C1 -
-
3KVW
1
DYRK2_HUMAN
A:
[98-413]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
H
K
V
H
Q
H
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
--
K
D
N
T
M
N
V
I
H
M
L
E
N
F
T
F
----
R
N
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
----
N
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
--
H
K
--
N
-
R
I
I
H
C
D
L
K
P
E
N
I
L
L
K
Q
Q
-----------------------
G
---------------------------
R
S
G
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
R
V
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
------
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
D
A
S
K
R
A
--
K
N
F
V
S
S
K
G
YP
R
Y
C
T
V
T
-----
T
L
S
------
D
------------
V
V
-
L
N
G
G
R
S
R
R
G
K
L
R
G
P
------
P
-
E
S
R
E
W
G
N
A
L
K
G
C
D
D
P
L
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
-----
1
PsiBlast_PDB
83.41
33%
-104
- C1 -
-
5LXC
9
DYRK2_HUMAN
A:
[77-392]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
H
K
V
H
Q
H
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
--
K
D
N
T
M
N
V
I
H
M
L
E
N
F
T
F
----
R
N
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
----
N
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
--
H
K
--
N
-
R
I
I
H
C
D
L
K
P
E
N
I
L
L
K
Q
Q
-----------------------
G
---------------------------
R
S
G
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
R
V
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
------
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
D
A
S
K
R
A
--
K
N
F
V
S
S
K
G
YPR
Y
C
T
V
T
-----
T
L
S
------
D
G
----------
S
V
V
-
L
N
G
G
R
S
RR
G
K
L
R
G
P
------
P
-
E
S
R
E
W
G
N
A
L
K
G
C
D
D
P
L
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
-----
36
HHSearch
78.13
29%
-90
- C1 -
-
3LLT
1
?
A:
[24-360]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
F
S
W
K
K
G
M
L
L
N
N
A
F
L
V
I
R
K
M
G
D
G
T
F
G
R
V
L
L
C
Q
H
-
I
D
N
K
K
Y
Y
A
V
K
V
V
R
N
I
K
K
Y
T
R
S
A
K
I
E
A
D
I
L
K
K
I
Q
N
D
---
D
I
N
N
N
N
I
V
K
Y
H
G
K
F
M
Y
----
Y
D
H
M
C
L
I
F
E
P
L
G
P
S
L
Y
E
I
I
T
R
N
N
----
Y
N
G
F
H
I
E
D
I
K
L
Y
C
I
E
I
L
K
A
L
N
Y
L
--
R
K
--
M
-
S
L
T
H
T
D
L
K
P
E
N
I
L
L
D
D
P
YF
E
K
S
L
I
T
V
R
R
VTDG
K
K
I
Q
I
Y
R
T
K
---------------------------
S
T
G
I
K
L
I
D
F
G
C
A
T
F
K
S
D
Y
H
G
S
I
I
N
T
R
Q
Y
R
A
P
E
V
I
L
N
L
G
W
D
V
S
S
D
M
W
S
F
G
C
V
L
A
E
L
Y
T
G
S
L
L
F
R
T
H
E
H
------
M
E
H
L
A
M
M
E
S
I
I
Q
P
I
P
K
N
M
L
Y
E
A
T
K
T
NG
S
K
Y
V
N
K
D
E
-----
L
K
L
-----
A
W
P
------
E
N
----------
A
S
S
I
N
S
I
K
H
V
-------
K
------
K
-
C
L
----
P
L
Y
K
I
I
K
H
E
L
F
C
D
F
L
Y
S
I
L
Q
I
D
P
T
L
R
P
S
P
A
E
L
L
K
H
K
F
L
E
-----
25
HHSearch
77.96
30%
-36
- C1 -
-
5MY8
24
?
A:
[15-382]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
I
G
D
L
F
N
G
R
Y
H
V
I
R
K
L
G
W
G
H
F
S
T
V
W
L
S
W
D
-
I
Q
G
K
K
F
V
A
M
K
V
V
K
S
A
E
H
Y
T
E
T
A
L
D
E
I
R
L
L
K
S
V
R
N
S
D
PN
D
P
N
R
E
M
V
V
Q
L
L
D
D
F
K
I
S
G
VN
G
T
H
I
C
M
V
F
E
V
L
G
H
H
L
L
K
W
I
I
K
S
----
N
Y
Q
G
L
P
L
P
C
V
K
K
I
I
Q
Q
V
L
Q
G
L
D
Y
L
--
H
T
--
K
C
R
I
I
H
T
D
I
K
P
E
N
I
L
L
S
V
N
-----------------------
E
Q
Y
I
R
R
L
A
A
E
A
T
E
W
Q
RFLVNPLEPKNAE
K
L
K
V
K
I
A
D
L
G
N
A
C
W
V
H
K
H
F
T
E
D
I
Q
T
R
Q
Y
R
S
L
E
V
L
I
G
S
G
Y
N
T
P
A
D
I
W
S
T
A
C
M
A
F
E
L
A
T
G
D
Y
L
F
E
P
H
S
G
EEYT
R
D
E
D
H
I
A
L
I
I
E
L
L
G
K
V
P
R
K
L
I
V
A
G
K
Y
S
--
K
E
F
F
T
K
K
G
-----
D
L
K
-----
H
I
T
------
K
L
----------
K
P
W
-
G
L
F
E
V
L
--------------
V
-
E
K
----
Y
E
W
S
Q
E
E
A
A
G
F
T
D
F
L
L
P
M
L
E
L
I
P
E
K
R
A
T
A
A
E
C
L
R
H
P
W
L
N
-----
38
HHSearch
74.66
26%
-60
- C1 -
-
5J1W
6
CLK1_HUMAN
A:
[8-335]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
--
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
H
----
H
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
----
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
--
H
S
--
N
-
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
-----------------------
D
Y
T
E
A
Y
N
PKIK
R
D
E
R
T
L
I----------
N
P
D
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
------
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
K
T
R
K
R
--
K
Y
-
F
H
H
D
R
-----
L
D
W
-----
D
E
H
------
S
S
-----------
A
G
-
R
Y
V
S
R
A
C
KP----
L
------
K
-
E
F
----
M
L
S
Q
D
V
E
H
E
R
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
---
39
HHSearch
72.94
26%
-61
- C1 -
-
1Z57
1
CLK1_HUMAN
A:
[8-335]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
--
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
H
----
H
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
----
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
--
H
S
--
N
-
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
-----------------------
D
Y
T
E
A
Y
NR
D
E
R
T
L
I--------------
N
P
D
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
------
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
K
T
R
K
R
--
K
-
Y
F
H
H
D
R
-----
L
D
W
-----
D
E
H
------
S
S
-----------
A
G
-
R
Y
V
S
R
A
C
KP----
L
------
K
-
E
F
----
M
L
S
Q
D
V
E
H
E
R
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
---
17
PsiBlast_PDB
70.89
36%
-114
- C1 -
-
5AIK
1
DYR1A_HUMAN
A:
[55-287]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
V
E
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
--
T
E
M
K
Y
Y
I
V
H
L
K
R
H
F
M
F
----
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
--
R
G
V
S
L
N
L
T
R
--
K
F
A
Q
Q
M
C
T
A
L
L
F
L
--
A
T
PE
L
-
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
P
-----------------------
K
---------------------------
R
S
A
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
------
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
----------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
70.47
36%
-118
- C1 -
-
4MQ1
3
DYR1A_HUMAN
A:
[34-264]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
V
E
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
--
T
E
M
K
Y
Y
I
V
H
L
K
R
H
F
M
F
----
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
--
R
G
V
S
L
N
L
T
R
--
K
F
A
Q
Q
M
C
T
A
L
L
F
L
--
A
T
PE
L
-
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
P
-----------------------
K
---------------------------
R
S
A
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
------
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
---------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
69.71
36%
-118
- C1 -
-
4YLJ
3
DYR1A_HUMAN
A:
[34-264]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
V
E
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
--
T
E
M
K
Y
Y
I
V
H
L
K
R
H
F
M
F
----
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
--
R
G
V
S
L
N
L
T
R
--
K
F
A
Q
Q
M
C
T
A
L
L
F
L
--
A
T
PE
L
-
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
P
-----------------------
K
---------------------------
R
S
A
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
------
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
---------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
69.49
36%
-112
- C1 -
-
5A54
1
DYR1A_HUMAN
A:
[36-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
V
E
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
--
T
E
M
K
Y
Y
I
V
H
L
K
R
H
F
M
F
----
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
--
R
G
V
S
L
N
L
T
R
--
K
F
A
Q
Q
M
C
T
A
L
L
F
L
--
A
T
PE
L
-
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
P
-----------------------
K
---------------------------
R
S
A
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
------
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
----------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
69.36
36%
-116
- C1 -
-
5A4L
1
DYR1A_HUMAN
A:
[36-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
V
E
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
--
T
E
M
K
Y
Y
I
V
H
L
K
R
H
F
M
F
----
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
--
R
G
V
S
L
N
L
T
R
--
K
F
A
Q
Q
M
C
T
A
L
L
F
L
--
A
T
PE
L
-
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
P
-----------------------
K
---------------------------
R
S
A
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
------
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
----------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
68.56
36%
-114
- C1 -
-
5A3X
1
DYR1A_HUMAN
A:
[36-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
V
E
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
--
T
E
M
K
Y
Y
I
V
H
L
K
R
H
F
M
F
----
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
--
R
G
V
S
L
N
L
T
R
--
K
F
A
Q
Q
M
C
T
A
L
L
F
L
--
A
T
PE
L
-
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
P
-----------------------
K
---------------------------
R
S
A
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
------
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
----------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
68.36
36%
-110
- C1 -
-
5A4E
1
DYR1A_HUMAN
A:
[36-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
V
E
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
--
T
E
M
K
Y
Y
I
V
H
L
K
R
H
F
M
F
----
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
--
R
G
V
S
L
N
L
T
R
--
K
F
A
Q
Q
M
C
T
A
L
L
F
L
--
A
T
PE
L
-
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
P
-----------------------
K
---------------------------
R
S
A
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
------
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
----------------------------------------------------------------------------------------------------------------------------