@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_22_0630: (2018-03-10 )
MRRVGDYEILDVVGEGAYSKVKRVRHIPTGCMFVAKIVPKTNQQVENDVRLEISILRRLKHKNIVQLIEILESTNNYYIILEPVMGGDLCDIIVGMDRPLPEQDVAALLIQLVAGVRACHRNGVAHRDLKPENLLLGTDGVLKISDFGLSRLHRESNFQASTNEYAHTLTGTLAYLAPEVFGGSYDAFRADIWSMGCIAYVLLTQNFPFGSTTDPHALEVRIRNGEVSIMPSSVSAEAKNLCKWLLSPRPEDRPTLDAVAQHDFFKRYLPAEYLRVTANRKSPIVHGANMNEFSSQVQEEAPSCSPSTASAKRKHHHVRSGSAARTSPSGSAVAGAATSSNRSSESGRDREDLVSHGTQDESGLGGYCGDV
Atome Classification :
(20 SA)
.........10........20........30........40--.---.---.-----.--------..-..---.50--........-60........70........80........90......---..100.......110.......120.......130....--..---.---140.......150.......160.......170.......180.------..-.----....190.......200.......210.......220....---.---.--.--230--..---......240.......250--.......260.....--..270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MRRVG
D
Y
E
I
L
D
V
VGE
G
A
Y
S
K
V
K
R
V
RHIP
T
G
C
M
F
V
A
K
IVPK---T---
N
---
Q
-----
Q
--------VE-N
D
---
V
R
L
--
E
I
S
I
L
R
R
L
-
K
H
K
N
I
V
Q
L
I
E
I
L
ESTN
N
Y
Y
I
I
L
EPVMGG
D
L
C
D
I
I
VGMD---RPL
P
E
Q
D
V
A
A
L
L
I
Q
L
V
A
G
V
R
A
C
H
RNGVAHRDLKPE
N
L
L
L--GT---D---
G
V
L
K
I
S
D
F
G
L
S
R
L
H
RESNFQAS
T
N
E
Y
A
H
T
L
T
G
T
L
A
Y
L
A
P
E
VF-G------GS-
Y
----
D
A
F
R
A
D
I
W
S
M
G
C
I
A
Y
V
L
L
TQNFPFGSTTDP
H
A
L
E
V
R
I
RNG
E
---
V
---
S
--
I
--MP---SS---V
S
A
E
A
K
N
L
C
K
W
L
LSPRPED--R
P
T
L
D
A
V
A
Q
H
D
F
F
K
R
--YL
P
A
E
Y
L
R
V
TANRKSPIVHGA
N
M
N
E
F
S
S
Q
V
Q
E
EAPSCSPST
A
S
A
K
R
K
HHHVRSGSAARTSPSGS
A
V
A
GAATSSNRSSESGR
D
R
E
D
L
V
SHGTQDESGLGGYCGDV
1
PsiBlast_PDB
79.37
42%
-19
- C1 -
-
4D28
-
CIPKO_ARATH
A:
[8-270]
---
V
G
K
Y
E
V
G
R
T
I
-----
A
K
V
K
F
A
R
N
T
D
T
G
D
N
V
A
I
K
I
M
A
K
---
S
T
I
L
K
---
N
-----
R
--------
M
V
-
D
Q
---
I
K
R
--
E
I
S
I
M
K
I
V
-
R
H
P
N
I
V
R
L
Y
E
V
L
A
S
K
S
K
I
Y
I
V
L
E
F
V
T
G
G
E
L
F
D
R
I
V
H
K
G
---
R
-
L
K
E
D
E
S
R
K
Y
F
Q
Q
L
V
D
A
V
A
H
C
H
S
K
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
--
D
T
---
N
---
G
N
L
K
V
S
D
F
G
L
S
A
L
P
Q
E
G
---------
L
N
D
T
C
G
T
P
N
Y
V
A
P
E
V
L
-
S
------
G
Q
G
Y
----
D
G
S
A
A
D
I
W
S
C
G
V
I
L
F
V
I
L
A
G
Y
L
P
F
-
S
E
T
D
L
P
G
L
Y
R
K
I
N
A
A
E
---
F
---
D
--
C
---
P
---
P
W
---
F
S
A
E
V
K
F
L
I
H
R
I
L
D
P
N
P
K
T
--
R
I
Q
I
Q
G
I
K
K
D
P
W
F
R
K
N-
Y
V
P
-----------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
75.33
38%
-27
- C1 -
-
4CZT
3
CIPKN_ARATH
A:
[9-272]
--
R
V
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
---
E
---
K
V
L
K
N
-----
K
--------
M
I
-
A
Q
---
I
K
R
--
E
I
S
T
M
K
L
I
-
K
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
---
R
-
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
--
D
A
---
N
---
G
A
L
K
V
S
D
F
G
L
S
A
L
P
Q
----
Q
V
R
E
D
G
L
L
H
T
T
C
G
T
P
N
Y
V
A
P
E
V
I
-
N
------
N
K
G
Y
----
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
-
E
D
S
N
L
T
S
L
Y
K
K
I
F
K
A
E
---
F
---
T
--
C
---
P
---
P
W
---
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
--
R
I
T
F
A
E
V
I
E
N
E
W
F
K
K
----------------------------------------------------------------------------------------------------------
46
Fugue
74.63
25%
-45
- C1 -
-
1TKI
-
TITIN_HUMAN
A:
[18-338]
K
E
L
Y
E
K
Y
M
I
A
E
D
L
G
R
G
E
F
G
I
V
H
R
C
V
E
T
S
S
K
K
T
Y
M
A
K
F
V
K
V
---
K
---
G
---
T
-----
D
--------
Q
V
--
L
---
V
K
K
--
E
I
S
I
L
N
I
A
-
R
H
R
N
I
L
H
L
H
E
S
F
E
S
M
E
E
L
V
M
I
F
E
F
I
S
G
L
D
I
F
E
R
I
N
T
S
A
---
F
E
L
N
E
R
E
I
V
S
Y
V
H
Q
V
C
E
A
L
Q
F
L
H
S
H
N
I
G
H
F
D
I
R
P
E
N
I
I
Y
--
Q
T
RR-
S
---
S
T
I
K
I
I
E
F
G
Q
A
R
Q
-------
L
K
P
G
D
N
F
R
L
L
F
T
A
P
E
Y
Y
A
P
E
V
H
-
Q
------
H
D
-
V
----
V
S
T
A
T
D
M
W
S
L
G
T
L
V
Y
V
L
L
S
G
I
N
P
F
L
A
E
T
N
Q
Q
I
I
E
-
N
I
M
N
A
E
---
Y
---
T
--
F
--
D
E
---
E
A
FKE
I
S
I
E
A
M
D
F
V
D
R
L
L
V
K
E
R
K
S
--
R
M
T
A
S
E
A
L
Q
H
P
W
L
K
Q
--
K
--------
I
E
R
V
S
T
K
V
I
R
T
L
K
H
R
R
Y
Y
H
T
L
I
K
K
D
L
N
M
V
V
S
A
A
R
I
S
C
--------
G
G
A
I
R
S
Q
K
G
V
S
V
A
K
V
K
V
A
S
I
------------------------------
3
PsiBlast_PDB
74.27
37%
-26
- C1 -
-
4CZU
3
CIPKN_ARATH
A:
[9-275]
--
R
V
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
---
E
---
K
V
L
K
N
-----
K
--------
M
I
-
A
Q
---
I
K
R
--
E
I
S
T
M
K
L
I
-
K
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
---
R
-
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
--
D
A
---
N
---
G
A
L
K
V
S
D
F
G
L
S
A
L
P
Q
----
Q
V
R
E
D
G
L
L
H
D
T
C
G
T
P
N
Y
V
A
P
E
V
I
-
N
------
N
K
G
Y
----
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
-
E
D
S
N
L
T
S
L
Y
K
K
I
F
K
A
E
---
F
---
T
--
C
---
P
---
P
W
---
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
--
R
I
T
F
A
E
V
I
E
N
E
W
F
K
K
----------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
72.36
36%
-56
- C1 -
-
3DAE
-
SNF1_YEAST
A:
[52-314]
---
I
G
N
Y
Q
I
V
K
T
L
G
E
G
S
F
G
K
V
K
L
A
Y
H
T
T
T
G
Q
K
V
A
L
K
I
I
N
K
KVL
A
-----------------------
Q
-
G
R
---
I
E
R
--
E
I
S
Y
L
R
L
L
-
R
H
P
H
I
I
K
L
Y
D
V
I
K
S
K
D
E
I
I
M
V
I
E
-
Y
A
G
N
E
L
F
D
Y
I
V
Q
R
D
---
K
-
M
S
E
Q
E
A
R
R
F
F
Q
Q
I
I
S
A
V
E
Y
C
H
R
H
K
I
V
H
R
D
L
K
P
E
N
L
L
L
--
D
E
---
H
---
L
N
V
K
I
A
D
F
-----------------------
G
S
P
N
Y
A
A
P
E
V
I
-
S
------
G
K
L
Y
----
A
G
P
E
V
D
V
W
S
C
G
V
I
L
Y
V
M
L
C
R
R
L
P
F
D
D
E
S
I
P
-
V
L
F
K
N
I
S
N
G
----
V
---
Y
--
T
--
L
P
---
K
F
---
L
S
P
G
A
A
G
L
I
K
R
M
L
I
V
N
P
L
N
--
R
I
S
I
H
E
I
M
Q
D
D
W
F
K
V
--
D
L
P
-
E
Y
L
-------------------------------------------------------------------------------------------------
26
HHSearch
70.79
32%
-70
- C1 -
-
1KOB
1
?
A:
[50-312]
---
Y
D
Y
Y
D
I
L
E
E
L
G
S
G
A
F
G
V
V
H
R
C
V
E
K
A
T
G
R
V
F
V
A
K
F
I
N
T
---
P
---
Y
---
P
-----
L
--------
D
K
-
Y
T
---
V
K
N
--
E
I
S
I
M
N
Q
L
-
H
H
P
K
L
I
N
L
H
D
A
F
E
D
K
Y
E
M
V
L
I
L
E
F
L
S
G
G
E
L
F
D
R
I
A
A
E
D
---
Y
K
M
S
E
A
E
V
I
N
Y
M
R
Q
A
C
E
G
L
K
H
M
H
E
H
S
I
V
H
L
D
I
K
P
E
N
I
M
C
--
E
T
---
K
KA-
S
S
V
K
I
I
D
F
G
L
A
T
K
L
N
P
D
-------
E
I
V
K
V
T
T
A
T
A
E
F
A
A
P
E
I
V
-
D
------
R
E
-
P
----
V
G
F
Y
T
D
M
W
A
I
G
V
L
G
Y
V
L
L
S
G
L
S
P
F
A
G
E
D
D
L
E
T
L
Q
N
-
V
K
R
C
D
W
E
F
D
---
E
--
D
--
A
F
---
S
S
---
V
S
P
E
A
K
D
F
I
K
N
L
L
Q
K
E
P
R
K
--
R
L
T
V
H
D
A
L
E
H
P
W
L
K
G
--
D
H
------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
69.51
34%
-51
- C1 -
-
4BL1
1
MELK_HUMAN
A:
[12-282]
------
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
---
N
---
T
---
L
----------------L
P
R
---
I
K
T
--
E
I
E
A
L
K
N
L
-
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
---
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
--
D
E
---
Y
---
H
K
L
K
L
I
D
F
G
L
C
-----
A
K
--------------
S
L
A
Y
A
A
P
E
L
I
Q
G
------
K
--------
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
-
D
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
K
---
Y
---
D
--
V
---
P
---
K
W
---
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
--
R
I
S
M
K
N
L
L
N
H
P
W
I
M
Q
DY
N
Y
P
V
E
W
-----
Q
S
K
N
P
F
I
H
-------------------------------------------------------------------------------------
40
HHSearch
69.40
32%
-32
* C1 *
-
3C0G
1
CSKP_HUMAN
B:
[22-294]
--
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
---
A
---
K
---
F
T
S
SPG
L
--------
S
T
-
E
D
---
L
K
R
--
E
A
S
I
C
H
M
L
-
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
--
A
S
---
K
ENS
A
P
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
S
G
------
L
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
-
K
------
R
E
-
P
----
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
K
E
R
--
L
F
E
G
I
I
K
G
K
---
Y
KMN
P
--
R
--
Q
W
---
S
H
---
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
--
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
--
R
D
------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
69.22
35%
-19
- C1 -
-
3IEC
-
MARK2_HUMAN
A:
[6-256]
---
I
G
N
Y
R
L
L
K
T
I
G
----
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
I
D
K
---
T
---
Q
---
L
-----
N
--------
S
S
-
S
L
---
Q
K
L
F
R
E
V
R
I
M
K
V
L
-
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
---
W
-
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
--
D
A
---
D
---
M
N
I
K
I
A
D
F
G
F
S
---
N
E
F
T
F
G
N
K
L
D
----
T
F
C
G
S
P
P
Y
A
A
P
E
L
F
Q
G
------
K
K
-
Y
----
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
-
Q
N
L
K
E
L
R
E
R
V
L
R
G
K
---
Y
---
R
--
I
---
P
---
F
Y
---
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
--
R
G
T
L
E
Q
I
M
K
----------------------------------------------------------------------------------------------------------------
21
HHSearch
69.11
31%
-80
- C1 -
-
2X4F
4
MYLK4_HUMAN
A:
[89-350]
----
Y
T
V
S
K
T
E
I
L
G
-----
Q
V
H
K
C
E
E
T
A
T
G
L
K
L
A
A
K
I
I
K
T
---
R
---
G
---
M
-----
K
--------
D
K
-
E
E
---
V
K
N
--
E
I
S
V
M
N
Q
L
-
D
H
A
N
L
I
Q
L
Y
D
A
F
E
S
K
N
D
I
V
L
V
M
E
Y
V
D
G
G
E
L
F
D
R
I
I
D
E
S
---
Y
N
L
T
E
L
D
T
I
L
F
M
K
Q
I
C
E
G
I
R
H
M
H
Q
M
Y
I
L
H
L
D
L
K
P
E
N
I
L
C
VN
R
D
---
A
---
K
Q
I
K
I
I
D
F
G
L
A
R
R
Y
K
P
R
-------
E
K
L
K
V
N
F
G
T
P
E
F
L
A
P
E
V
V
-
N
------
Y
D
-
F
----
V
S
F
P
T
D
M
W
S
V
G
V
I
A
Y
M
L
L
S
G
L
S
P
F
L
G
D
N
D
A
E
T
L
N
N
I
L
A
C
R
W
---
D
LE-
D
--
E
--
E
F
---
Q
D
---
I
S
E
E
A
K
E
F
I
S
K
L
L
I
K
E
K
S
W
--
R
I
S
A
S
E
A
L
K
H
P
W
L
S
D
--
H
K
------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
68.72
36%
-47
- C1 -
-
3HYH
-
SNF1_YEAST
A:
[54-314]
-----
N
Y
Q
I
V
K
T
L
G
E
G
---
K
V
K
L
A
Y
H
T
T
T
G
Q
K
V
A
L
K
I
I
N
K
K-------------------------
M
Q
-
G
R
---
I
E
R
--
E
I
S
Y
L
R
L
L
-
R
H
P
H
I
I
K
L
Y
D
V
I
K
S
K
D
E
I
I
M
V
I
E
-
Y
A
G
N
E
L
F
D
Y
I
V
Q
R
D
---
K
-
M
S
E
Q
E
A
R
R
F
F
Q
Q
I
I
S
A
V
E
Y
C
H
R
H
K
I
V
H
R
D
L
K
P
E
N
L
L
L
--
D
E
---
H
---
L
N
V
K
I
A
D
F
G
L
S
----------------------
P
N
Y
A
A
P
E
V
I
-
S
------
G
K
L
Y
----
A
G
P
E
V
D
V
W
S
C
G
V
I
L
Y
V
M
L
C
R
R
L
P
F
D
D
E
S
I
P
-
V
L
F
K
N
I
S
N
G
----
V
---
Y
--
T
--
L
P
---
K
F
---
L
S
P
G
A
A
G
L
I
K
R
M
L
I
V
N
P
L
N
--
R
I
S
I
H
E
I
M
Q
D
D
W
F
K
V
--
D
L
P
-
E
Y
L
-------------------------------------------------------------------------------------------------
41
HHSearch
68.70
32%
-37
- C1 -
-
3C0I
1
CSKP_HUMAN
A:
[22-294]
--
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
---
A
---
K
---
F
T
S
SPG
L
--------
S
T
-
E
D
---
L
K
R
--
E
A
S
I
C
H
M
L
-
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
--
A
S
---
K
ENS
A
P
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
S
G
------
L
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
-
K
------
R
E
-
P
----
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
K
E
R
--
L
F
E
G
I
I
K
G
K
---
Y
K
M
N
P
--
R
--
Q
W
---
S
H
---
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
--
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
--
R
D
------------------------------------------------------------------------------------------------------
34
HHSearch
67.72
33%
-26
- C1 -
-
2Y7J
1
PHKG2_HUMAN
D:
[93-365]
---
Y
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
V
-----------------
R
LSPEQLEE
V
R
-
E
A
---
T
R
R
--
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
-
K
---
V
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
--
D
D
---
N
---
M
Q
I
R
L
S
D
F
G
F
S
C
H
L
E
P
G
-------
E
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
-
K
CSMDET
H
P
-
G
----
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
R
R
Q
I
L
M
L
-
R
M
I
M
E
G
Q
---
Y
---
Q
F-
S
SP
E
W
---
D
D
---
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
--
R
L
T
A
E
Q
A
L
Q
H
P
F
F
E
R
----------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
67.16
32%
-19
- C1 -
-
3HZT
9
?
A:
[6-319]
------
Y
Q
R
V
K
K
L
G
S
G
A
Y
G
E
V
L
L
C
K
D
K
L
T
G
A
E
R
A
I
K
I
I
K
K
---
S
---
S
---
V
-----
T
--------
T
T
-
S
N
S
G
A
L
L
D
--
E
V
A
V
L
K
Q
L
-
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
R
N
Y
Y
L
V
M
E
V
Y
R
G
G
E
L
F
D
E
I
I
-
L
R
---
Q
K
F
S
E
V
D
A
A
V
I
M
K
Q
V
L
S
G
T
T
Y
L
H
K
H
N
I
V
H
R
D
L
K
P
E
N
L
L
L
--
E
S
KSR
D
---
A
L
I
K
I
V
D
F
G
L
S
-----
A
H
F
E
V
G
----------
T
A
Y
Y
I
A
P
E
V
L
-
R
------
K
K
-
Y
----
D
E
-
K
C
D
V
W
S
C
G
V
I
L
Y
I
L
L
C
G
Y
P
P
F
G
G
Q
T
D
Q
E
I
L
K
-
R
V
E
K
G
K
---
F
---
S
--
F
--
D
P
PDW
T
Q
---
V
S
D
E
A
K
Q
L
V
K
L
M
L
T
Y
E
P
S
K
--
R
I
S
A
E
E
A
L
N
H
P
W
I
V
K
--
F
C
S
Q
----
V
G
K
H
A
L
T
G
A
L
--
G
N
M
K
K
F
Q
S
----------------------------------------------------------------------------
22
HHSearch
67.14
28%
-79
- C1 -
-
1TKI
-
TITIN_HUMAN
A:
[21-282]
---
Y
E
K
Y
M
I
A
E
D
L
G
R
G
E
F
G
I
V
H
R
C
V
E
T
S
S
K
K
T
Y
M
A
K
F
V
K
V
---
K
---
G
---
T
--------------
D
Q
-
V
L
---
V
K
K
--
E
I
S
I
L
N
I
A
-
R
H
R
N
I
L
H
L
H
E
S
F
E
S
M
E
E
L
V
M
I
F
E
F
I
S
G
L
D
I
F
E
R
I
N
T
S
A
---
F
E
L
N
E
R
E
I
V
S
Y
V
H
Q
V
C
E
A
L
Q
F
L
H
S
H
N
I
G
H
F
D
I
R
P
E
N
I
I
Y
--
Q
T
RR-
S
---
S
T
I
K
I
I
E
F
G
Q
A
R
Q
L
K
P
G
-------
D
N
F
R
L
L
F
T
A
P
E
Y
Y
A
P
E
V
H
-
Q
------
H
D
-
V
----
V
S
T
A
T
D
M
W
S
L
G
T
L
V
Y
V
L
L
S
G
I
N
P
F
L
A
E
T
N
Q
Q
I
I
-
E
N
I
M
N
A
E
---
Y
TFD
E
--
E
--
A
F
---
K
E
---
I
S
I
E
A
M
D
F
V
D
R
L
L
V
K
E
R
K
S
--
R
M
T
A
S
E
A
L
Q
H
P
W
L
K
Q
--
K
I
------------------------------------------------------------------------------------------------------
32
HHSearch
67.13
33%
-26
- C1 -
-
2Y7J
1
PHKG2_HUMAN
C:
[93-364]
---
Y
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
V
---
T
---
A
---
E
-----
R
LSPEQLEE
V
R
-
E
A
---
T
R
R
--
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
-
K
---
V
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
--
D
D
---
N
---
M
Q
I
R
L
S
D
F
G
F
S
C
H
L
E
P
G
-------
E
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
-
K
CSMDET
H
P
-
G
----
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
R
R
Q
I
L
M
L
-
R
M
I
M
E
G
Q
---
Y
---
Q
F-
S
SP
E
W
---
D
D
---
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
--
R
L
T
A
E
Q
A
L
Q
H
P
F
F
E
-----------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
67.02
36%
-20
- C1 -
-
5KZ8
1
MARK2_HUMAN
A:
[32-282]
---
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
I
D
K
---
T
---
Q
---
L
-----
N
--------
S
S
-
S
L
---
Q
K
L
F
R
E
V
R
I
M
K
V
L
-
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
---
R
-
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
--
D
A
---
D
---
M
N
I
K
I
A
D
F
G
---------------------
C
G
S
P
P
Y
A
A
P
E
L
F
Q
G
------
K
K
-
Y
----
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
-
Q
N
L
K
E
L
R
E
R
V
L
R
G
K
---
Y
---
R
--
I
---
P
---
F
Y
---
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
--
R
G
T
L
E
Q
I
M
K
----------------------------------------------------------------------------------------------------------------
31
HHSearch
66.62
28%
-24
- C1 -
-
4WOT
1
ROCK2_HUMAN
B:
[69-340]
----
E
D
Y
D
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
A
S
Q
K
V
Y
A
M
K
L
L
S
K
---
F
---
E
---
M
I
K
R
--
S
--------
D
S
-
A
F
---
F
W
E
--
E
R
D
I
M
A
F
A
-
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
-----
Y
D
V
P
E
K
W
A
K
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
M
G
L
I
H
R
D
V
K
P
D
N
M
L
L
--
D
K
---
H
---
G
H
L
K
L
A
D
F
G
T
C
M
K
M
D
E
T
G
-----
M
V
H
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
-
K
------
S
Q
-
G
GDGF
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
-
K
I
M
D
H
K
N--
S
---
L
CF
P
--
E
D
---
A
E
---
I
S
K
H
A
K
N
L
I
C
A
F
L
T
D
R
E
V
R
LG
R
N
G
V
E
E
I
R
Q
H
P
F
F
K
N
--
D
Q
W
-----------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
66.59
36%
-22
- C- -
-
2R0I
-
MARK2_RAT
A:
[50-300]
---
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
I
D
K
---
T
---
Q
---
L
-----
N
--------
S
S
-
S
L
---
Q
K
L
F
R
E
V
R
I
M
K
V
L
-
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
---
R
-
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
--
D
A
---
D
---
M
N
I
K
I
A
D
F
-----------------------
G
S
P
P
Y
A
A
P
E
L
F
Q
G
------
K
K
-
Y
----
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
-
Q
N
L
K
E
L
R
E
R
V
L
R
G
K
---
Y
---
R
--
I
---
P
---
F
Y
---
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
--
R
G
T
L
E
Q
I
M
K
----------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
66.10
36%
-22
- C1 -
-
5EAK
1
MARK2_HUMAN
A:
[14-264]
---
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
I
D
K
---
T
---
Q
---
L
-----
N
--------
S
S
-
S
L
---
Q
K
L
F
R
E
V
R
I
M
K
V
L
-
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
---
R
-
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
--
D
A
---
D
---
M
N
I
K
I
A
D
F
G
F
S
------------------
F
C
G
S
P
P
Y
A
A
P
E
L
F
Q
G
------
K
K
-
Y
----
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
-
Q
N
L
K
E
L
R
E
R
V
L
R
G
K
---
Y
---
R
--
I
---
P
---
F
Y
---
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
--
R
G
T
L
E
Q
I
M
K
----------------------------------------------------------------------------------------------------------------