@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_22_0770: (2018-03-10 )
MQSSASLPEQQPVNGSSDPQNHHYVNPLVSSFPTVVGPKLPCKYRVRRAIGRGAFSTVWLLINNRTGETVVGKLSDASHSSSACKAFAEAEVENMRCCSHPNIISLIETFEAGEKSLYILEYANAGDLQAQVDTRAQPPPGANDGTPIPYREDEALVIFAQLSLAIRYLHDRRIMHRDLKTSNVLLTRSGLIKLGDFGFSRQYQESVSGEVGKTFCGTPYYLAPEMWQRQSYSYKADIWSLGVIMYELLALKKPFQATNLSELMETVTRQGSFDPLPADRYSSDMISLVNQMLRVDPSERPSINDILALPLFQQRGLTILKINVRRIKNLDAEVRTRLVEDVEAVLGDNNLSSEASPL
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80-----.------........90.......-.100......-.110.......-120.......130.......140.......150.......160.......170.-......180.....--..---190--.........200.......210.......220......------.230.......240.......250.......260.......-270.-.-......280.......290.......300.......310.----......------320.......330....-----...340.......350......----------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MQSSASLPEQQPVNGSSDPQNHH
Y
V
N
P
L
V
S
SFPTVVGPKL
P
C
K
Y
R
V
R
R
A
IGRGA
F
S
T
V
W
L
L
I
NNRTGE
T
V
V
G
KLSDASH
S
------
S
------
S
A
C
K
A
F
A
E
A
E
V
ENMRCC-SHP
N
I
I
S
L
I
E
-
T
F
EAGE
K
S
L
Y
I
-
L
E
YANAGD
L
Q
A
QVDTRAQPPPGANDGTPIPYRED
E
A
L
V
I
F
A
Q
L
S
L
A
I
R
Y
L
H
D
R
R
-
I
M
H
R
DLKTS
N
V
L
L
T--RS---G----
L
I
KLGDFG
F
S
R
Q
Y
Q
E
S
VSGEVGKTFCGTPYYLA
P
E
M
W
Q
------RQSYSYK
A
D
I
W
S
L
G
V
I
M
Y
E
L
L
A
LKKPFQAT
N
L
S
E
L
M
E
T
V
T
R-QG-S-F-DPLP
A
D
RY
S
S
D
M
I
S
L
V
N
Q
M
L
RVDPSERPSI
N
D
I
L
AL
P
L
F
Q
----QRG
L
T
I
------
L
K
I
N
V
R
R
I
KNL
D
A
E
V
R
T
-----
R
L
V
E
D
V
E
A
V
LGDNNLSSEASPL----------------
1
PsiBlast_PDB
80.40
35%
-133
- C1 -
-
4APC
-
NEK1_HUMAN
A:
[25-283]
------------------------------------------
K
Y
V
R
L
Q
K
I
------
K
A
I
L
V
K
S
T
E
D
G
R
Q
Y
V
I
K
E
I
N
I
S
R
M
------
S
------
S
K
E
R
E
E
S
R
R
E
V
A
V
L
A
N
M
-
K
H
P
N
I
V
Q
Y
R
E
-
S
F
E
E
N
G
S
L
Y
I
V
-
M
D
Y
C
E
G
G
D
L
F
K
R
I
N
--------
A
Q
K
G
--
V
L
F
Q
E
D
Q
I
L
D
W
F
V
Q
I
C
L
A
L
K
H
V
H
D
R
K
-
I
L
H
R
D
I
K
S
Q
N
I
F
L
T
--
K
D
---
G
----
T
V
Q
L
G
D
F
G
I
A
R
V
L
N
S
T
V
--
E
L
A
R
A
C
I
G
T
P
Y
Y
L
S
P
E
I
C
E
------
N
K
P
Y
N
N
K
S
D
I
W
A
L
G
C
V
L
Y
E
L
C
T
L
K
H
A
F
E
A
G
S
M
K
N
L
V
L
K
I
I
--
S
G
-
S
-
F
-
P
P
V
S
L
-
H
Y
S
Y
D
L
R
S
L
V
S
Q
L
F
K
R
N
P
R
D
R
P
S
V
N
S
I
L
E
K
G
F
I
A
----
K
R
----------------------------------------------------------------------
2
PsiBlast_PDB
79.91
35%
-133
- C1 -
-
4B9D
1
NEK1_HUMAN
A:
[25-283]
------------------------------------------
K
Y
V
R
L
Q
K
I
------
K
A
I
L
V
K
S
T
E
D
G
R
Q
Y
V
I
K
E
I
N
I
S
R
M
------
S
------
S
K
E
R
E
E
S
R
R
E
V
A
V
L
A
N
M
-
K
H
P
N
I
V
Q
Y
R
E
-
S
F
E
E
N
G
S
L
Y
I
V
-
M
D
Y
C
E
G
G
D
L
F
K
R
I
N
--------
A
Q
K
G
--
V
L
F
Q
E
D
Q
I
L
D
W
F
V
Q
I
C
L
A
L
K
H
V
H
D
R
K
-
I
L
H
R
D
I
K
S
Q
N
I
F
L
T
--
K
D
---
G
----
T
V
Q
L
G
D
F
G
I
A
R
V
L
N
S
T
V
--
E
L
A
R
A
C
I
G
T
P
Y
Y
L
S
P
E
I
C
E
------
N
K
P
Y
N
N
K
S
D
I
W
A
L
G
C
V
L
Y
E
L
C
T
L
K
H
A
F
E
A
G
S
M
K
N
L
V
L
K
I
I
--
S
G
-
S
-
F
-
P
P
V
S
L
-
H
Y
S
Y
D
L
R
S
L
V
S
Q
L
F
K
R
N
P
R
D
R
P
S
V
N
S
I
L
E
K
G
F
I
A
----
K
R
----------------------------------------------------------------------
12
PsiBlast_PDB
71.27
36%
-32
- C1 -
-
2W5A
5
NEK2_HUMAN
A:
[8-271]
-------------------------------------------
Y
E
V
L
Y
T
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
------
T
------
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
-
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
-
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
-------
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
--
L
H
R
D
L
K
P
A
N
V
F
L
D
--
G
K
---
Q
----
N
V
K
L
G
D
F
G
L
A
R
I
L
---
T
S
--
F
A
K
T
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
------
R
M
-
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
E
L
A
G
K
I
-
R
-
E
G
-
K
-
F
-
R
R
I
P
Y
-
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
-----------------------------------------------------------------------------
33
HHSearch
70.68
30%
-55
- C1 -
-
2BDW
-
KCC2D_CAEEL
A:
[6-275]
-------------------------------------
T
K
F
S
D
N
Y
D
V
K
E
E
L
G
K
G
A
F
S
V
V
R
R
C
V
H
K
T
T
G
L
E
F
A
A
K
I
I
N
T
K
K
L
------
S
------
A
R
D
F
Q
K
L
E
R
E
A
R
I
C
R
K
L
-
Q
H
P
N
I
V
R
L
H
D
-
S
I
Q
E
E
S
F
H
Y
L
V
-
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
------------
F
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
I
A
Y
C
H
S
N
G
-
I
V
H
R
N
L
K
P
E
N
L
L
L
A
--
S
K
AKG
A
----
A
V
K
L
A
D
F
G
L
A
I
E
V
N
D
S
E
---
A
W
H
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
K
------
K
D
P
Y
S
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
H
R
L
Y
A
Q
I
K
A
-
G
A
-
Y
D
Y
-
P
S
P
E
W
D
T
V
T
P
E
A
K
S
L
I
D
S
M
L
T
V
N
P
K
K
R
I
T
A
D
Q
A
L
K
V
P
W
I
C
----
N
R
E
---------------------------------------------------------------------
32
HHSearch
68.95
30%
-13
* C1 *
-
2Y7J
1
PHKG2_HUMAN
C:
[92-364]
---------------------------------------
F
Y
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
V
T
A
E
------
R
LSPEQL
E
E
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
-
S
Y
E
S
S
S
F
M
F
L
V
-
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
V
------------
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
-
I
V
H
R
D
L
K
P
E
N
I
L
L
D
--
D
N
---
M
----
Q
I
R
L
S
D
F
G
F
S
C
H
L
E
P
G
E
---
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
CSMDET
H
P
G
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
R
R
Q
I
L
M
L
R
M
I
M
E
-
G
Q
-
Y
-
Q
F
S
S
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
A
E
Q
A
L
Q
H
P
F
F
E
----------------------------------------------------------------------------
25
HHSearch
67.85
32%
-41
- C1 -
-
3C0I
1
CSKP_HUMAN
A:
[22-294]
---------------------------------------
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
S---
P
------
G
L
S
T
E
D
L
K
R
E
A
S
I
C
H
M
L
-
K
H
P
H
I
V
E
L
L
E
-
T
Y
S
S
D
G
M
L
Y
M
V
-
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
A
--------
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
-
I
I
H
R
D
V
K
P
H
C
V
L
L
A
--
S
K
ENS
A
----
P
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
S
G
--
L
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
------
R
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
K
E
R
-
L
F
E
G
I
I
K
-
G
K
Y
K
-
M
-
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
----
E
R
D
---------------------------------------------------------------------
20
PsiBlast_PDB
66.77
36%
-42
- C1 -
-
2XKD
1
NEK2_HUMAN
A:
[8-271]
-------------------------------------------
Y
E
V
L
Y
T
I
G
T
G
---
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
------
T
------
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
-
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
-
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
-------
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
D-----
L
K
P
A
N
V
F
L
D
--
G
K
---
Q
----
N
V
K
L
G
D
F
----------------
T
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
------
R
M
S
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
E
L
A
G
K
I
-
R
-
E
G
-
K
-
F
-
R
R
I
P
Y
-
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
-----------------------------------------------------------------------------
26
HHSearch
65.98
32%
-33
- C1 -
-
3C0G
1
CSKP_HUMAN
B:
[22-294]
---------------------------------------
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
S---
P
------
G
L
S
T
E
D
L
K
R
E
A
S
I
C
H
M
L
-
K
H
P
H
I
V
E
L
L
E
-
T
Y
S
S
D
G
M
L
Y
M
V
-
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
A
--------
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
-
I
I
H
R
D
V
K
P
H
C
V
L
L
A
--
S
K
ENS
A
----
P
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
S
G
--
L
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
------
R
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
K
E
R
-
L
F
E
G
I
I
K
-
G
K
Y
K
-
M
-
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
----
E
R
D
---------------------------------------------------------------------
30
HHSearch
65.02
25%
-113
- C1 -
-
4XBR
1
INKA1_HUMAN (first)
A:
[93-352]
----------------------------------------
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
Q
--------------
Q
R
R
E
L
L
F
N
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
-
S
Y
L
V
G
D
E
L
W
V
V
-
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
T
-------------
R
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
-
V
I
H
R
D
I
K
S
D
S
I
L
L
T
--
H
D
---
G
----
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
--
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
------
R
L
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
R
D
-
N
L
-
P
-
P
-
R
L
K
N
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
A
----
K
A
G
P
--------------------------------------------------------------------
36
HHSearch
64.99
30%
-9
- C1 -
-
2Y7J
1
PHKG2_HUMAN
D:
[92-364]
---------------------------------------
F
Y
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
V
---RLSPEQ
L
------
E
E
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
-
S
Y
E
S
S
S
F
M
F
L
V
-
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
V
------------
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
-
I
V
H
R
D
L
K
P
E
N
I
L
L
D
--
D
N
---
M
----
Q
I
R
L
S
D
F
G
F
S
C
H
L
E
P
G
E
---
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
CSMDET
H
P
G
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
R
R
Q
I
L
M
L
R
M
I
M
E
-
G
Q
-
Y
-
Q
F
S
S
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
A
E
Q
A
L
Q
H
P
F
F
E
----------------------------------------------------------------------------
22
HHSearch
64.10
26%
26
- C1 -
-
2X0G
-
DAPK1_HUMAN
A:
[7-320]
-------------------------------------
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
------
K
SSRR--
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
-
Q
H
P
N
V
I
T
L
H
E
-
V
Y
E
N
K
T
D
V
I
L
I
-
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
------------
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
-
I
A
H
F
D
L
K
P
E
N
I
M
L
L
--
D
R
---
N
VP
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
N
---
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
A
N
V
S
A
-
V
N
Y
E
-
F
-
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
----
P
K
D
T
Q
Q
A
L
S
R
K
A
S
A
V
N
M
E
K
F
K
K
F
A
--
A
R
K
-----
K
W
K
Q
S
V
R
L
I
S
L
C
Q
R
L
S
R
---------------------
46
Fugue
63.29
22%
-34
- C1 -
-
1KOB
1
?
A:
[23-374]
-------------
I
N
D
Y
D
K
F
Y
E
D
I
W
K
K
Y
V
P
Q
P
V
E
V
K
Q
G
S
V
Y
D
Y
Y
D
I
L
E
E
L
G
S
G
A
F
G
V
V
H
R
C
V
E
K
A
T
G
R
V
F
V
A
K
F
I
N
T
P
--------
Y
------
P
L
D
K
Y
T
V
K
N
E
I
S
I
M
N
Q
L
-
H
H
P
K
L
I
N
L
H
D
-
A
F
E
D
K
Y
E
M
V
L
I
-
L
E
F
L
S
G
G
E
L
F
D
R
I
A
A
E
-----------
D
Y
K
M
S
E
A
E
V
I
N
Y
M
R
Q
A
C
E
G
L
K
H
M
H
E
H
S
-
I
V
H
L
D
I
K
P
E
N
I
M
C
E
TK
K
A
---
S
----
S
V
K
I
I
D
F
G
L
A
T
K
L
N
---
P
D
E
I
V
K
V
T
T
A
T
A
E
F
A
A
P
E
I
V
D
------
R
E
P
V
G
F
Y
T
D
M
W
A
I
G
V
L
G
Y
V
L
L
S
G
L
S
P
F
A
G
E
D
D
L
E
T
L
Q
N
V
K
R
C
D
W
-
E
-
F
-
D
E
D
A
F
S
S
V
S
P
E
A
K
D
F
I
K
N
L
L
Q
K
E
P
R
K
R
L
T
V
H
D
A
L
E
H
P
W
L
K
GDHS
N
L
T
S
R
I
------
P
S
S
R
Y
N
K
I
R
Q
K
I
K
E
K
Y
A
-----
D
W
P
A
P
Q
P
A
I
G
R
I
A
N
F
S
S
L
R
K
H
R
PQEYQ
I
Y
D
S
Y
F
DRKEA
15
PsiBlast_PDB
63.21
36%
-30
- C1 -
-
2XK4
1
NEK2_HUMAN
A:
[8-271]
-------------------------------------------
Y
E
V
L
Y
T
I
G
T
--
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
------
T
------
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
-
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
-
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
-------
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
----
R
D
L
K
P
A
N
V
F
L
D
--
G
K
---
Q
----
N
V
K
L
G
D
F
G
L
---------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
------
R
M
--
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
E
L
A
G
K
I
-
R
-
E
G
-
K
-
F
-
R
R
I
P
Y
-
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
-----------------------------------------------------------------------------
18
PsiBlast_PDB
63.06
36%
-40
- C1 -
-
2XK8
1
NEK2_HUMAN
A:
[8-271]
-------------------------------------------
Y
E
V
L
Y
T
I
G
T
----
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
------
T
------
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
-
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
-
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
-------
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
----
R
D
L
K
P
A
N
V
F
L
D
--
G
K
---
Q
----
N
V
K
L
G
D
F
-----------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
----------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
E
L
A
G
K
I
-
R
-
E
G
-
K
-
F
-
R
R
I
P
Y
-
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
-----------------------------------------------------------------------------
17
PsiBlast_PDB
62.68
36%
-32
- C1 -
-
2XK7
1
NEK2_HUMAN
A:
[8-271]
-------------------------------------------
Y
E
V
L
Y
T
I
G
T
G
---
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
------
T
------
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
-
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
-
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
-------
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
----
R
D
L
K
P
A
N
V
F
L
D
--
G
K
---
Q
----
N
V
K
L
G
D
F
------------------
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
----------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
E
L
A
G
K
I
-
R
-
E
G
-
K
-
F
-
R
R
I
P
Y
-
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
-----------------------------------------------------------------------------
16
PsiBlast_PDB
62.14
36%
-28
- C1 -
-
2XK6
1
NEK2_HUMAN
A:
[8-271]
-------------------------------------------
Y
E
V
L
Y
T
I
G
-----
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
------
T
------
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
-
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
-
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
-------
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
----
R
D
L
K
P
A
N
V
F
L
D
--
G
K
---
Q
----
N
V
K
L
G
D
-------------------
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
------
R
---
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
E
L
A
G
K
I
-
R
-
E
G
-
K
-
F
-
R
R
I
P
Y
-
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
-----------------------------------------------------------------------------
14
PsiBlast_PDB
62.14
36%
-25
- C1 -
-
2XK3
1
NEK2_HUMAN
A:
[8-271]
-------------------------------------------
Y
E
V
L
Y
T
I
G
T
----
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
------
T
------
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
-
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
-
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
-------
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
----
R
D
L
K
P
A
N
V
F
L
D
--
G
K
---
Q
----
N
V
K
L
G
D
F
G
-----------------
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
------
R
---
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
E
L
A
G
K
I
-
R
-
E
G
-
K
-
F
-
R
R
I
P
Y
-
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
-----------------------------------------------------------------------------
21
HHSearch
61.38
26%
22
- C1 -
-
4B4L
3
DAPK1_HUMAN
A:
[7-305]
-----------------------------------
R
Q
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
------
K
SSRR--
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
-
Q
H
P
N
V
I
T
L
H
E
-
V
Y
E
N
K
T
D
V
I
L
I
-
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
------------
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
-
I
A
H
F
D
L
K
P
E
N
I
M
L
L
--
D
R
---
N
VP
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
N
---
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
A
N
V
S
A
-
V
N
Y
E
-
F
-
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
----
P
K
D
T
Q
Q
A
L
S
R
K
A
S
A
V
N
M
E
K
F
K
K
F
A
--
A
A
K
-------------------------------------------
45
Fugue
61.24
24%
-39
- C1 -
-
1TKI
-
TITIN_HUMAN
A:
[18-338]
-------------------------------------
K
E
L
Y
E
K
Y
M
I
A
E
D
L
G
R
G
E
F
G
I
V
H
R
C
V
E
T
S
S
K
K
T
Y
M
A
K
F
V
K
V
K
G
---------------
T
D
Q
V
L
V
K
K
E
I
S
I
L
N
I
A
-
R
H
R
N
I
L
H
L
H
E
-
S
F
E
S
M
E
E
L
V
M
I
-
F
E
F
I
S
G
L
D
I
F
E
R
I
N
T
S
-----------
A
F
E
L
N
E
R
E
I
V
S
Y
V
H
Q
V
C
E
A
L
Q
F
L
H
S
H
N
-
I
G
H
F
D
I
R
P
E
N
I
I
Y
Q
TR
R
S
---
S
----
T
I
K
I
I
E
F
G
Q
A
R
Q
L
K
P
---
G
D
N
F
R
L
L
F
T
A
P
E
Y
Y
A
P
E
V
H
Q
------
H
D
V
V
S
T
A
T
D
M
W
S
L
G
T
L
V
Y
V
L
L
S
G
I
N
P
F
L
A
E
T
N
Q
Q
I
I
E
N
I
M
N
-
A
E
Y
T
-
F
-
D
E
E
A
F
K
E
I
S
I
E
A
M
D
F
V
D
R
L
L
V
K
E
R
K
S
R
M
T
A
S
E
A
L
Q
H
P
W
L
K
----
Q
K
I
E
R
V
------
S
T
K
V
I
R
T
L
K
H
R
R
Y
Y
H
T
L
IKKDL
N
M
V
V
S
A
A
R
I
S
C
G
G
A
I
R
S
Q
K
G
V
S
V
A
K
V
K
V
A
SI-------
19
PsiBlast_PDB
61.13
36%
-19
- C1 -
-
2XKC
1
NEK2_HUMAN
A:
[8-271]
-------------------------------------------
Y
E
V
L
Y
T
I
G
T
--
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
------
T
------
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
-
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
-
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
-------
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
------
L
K
P
A
N
V
F
L
D
--
G
K
---
Q
----
N
V
K
L
G
D
--------------------
G
T
P
Y
Y
M
S
P
E
Q
M
N
------
R
---
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
E
L
A
G
K
I
-
R
-
E
G
-
K
-
F
-
R
R
I
P
Y
-
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
-----------------------------------------------------------------------------