@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_22_0970: (2018-03-10 )
MMTSMAVSAPVMPPATAREHRPVRAARATASTTSSAGRSARSARSVHFALEPVARDVQKHMERQLWHWLEKTHSMLRPLEASARGQVQVMERATVAATAATAAPAVVVKAVAVTLPPYREHAHDASEDEDISWSRAQLVPSVSLALWEQRRRQLRHVAGVVDVYTLASMLRDTREGSPRKRHGSSGGAVRFCTSFLGSSCDTTASGRVPMPVLDADELREQGWALDVVVKQPTQQQHHQSGSRGRSSSGASPLPHPTVFLFARDYIDHAEVLWNLVQERWGRERLPVTVMPTWVNTAAVFGSDDPQVEATAASALTDDALEKLRRHIGRWLKGASAADKTKKRVAGQAAALAIDTYGAAVAAAVASDEQALTAHDAADITWGVCTALARLHRAGLAHGNLKPNNVLIAQPVDGRSAAQAEQAPREVHVTDHLLPLLPDQLVEPGELLKLPWAAAVAVGGAPAERRKSMPVTMSGYVCLKQHEEAASMSYLCGGGLSDAVAAPAFSLSGFILSKAVSGNDDAAVLEGGVDCLSNTAYEAVLLQHLTAPERVLLVAVDSSTVNAGVRKDAAEVGTALSTGGPHFRVWVDTQHATPASDIYALGVLLYIMLIGRLPPLPRYRRASRGTFSAAAVGARPQRMYEAVVNDVVCALYENAARHSFKCDPSPMMDELKAFLQSAAAREHLPLVLALARAGVRPTTMDILVGMLHVNPAKRLSLAQLQHHAFFRTYGRRRHTLRAEFAEAARRVQHAAPVMRKDPLGHSVAAAVGRRMMPQNMGASAKAAAEHPRSPPTPSAGHLATVAPRVPSMASMPSRINERGTPDPVLSPASPNAAAASRSASMASVGSAGEEAPRSTPRSPPPQLLRAPHAVYLPYKRRETTISPPSPSPTLPAQEGERRQRKEPSCSLLQSRALQLSAPSCMGQTHYDLPRRRASIQDDMDRPLDRSCRSLITAVSNRSVGAALIPHAVRRLSPLGHEASVLSQTSLDATPAARLGKAGPALHAPRRPVMRRQSAWMMPHRYSVYVVSLALLFVVRLRRRRERTWLLGRMRRCQR
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......-----310-.........320-..---.-----------.-------.....330....----.----.---------.----340.......350.......360.....---..370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470..-------------.....480.......490.......500.......510.......520.......530.......540.......550.......560-----........570..---...--------..580..----.....590.......600.......610....----...620.......630.......640....---...650.......660.......670.......----680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MMTSMAVSAPVMPPATAREHRPV
R
A
ARATASTTSSAGRSARSA
R
S
V
H
F
A
L
E
P
V
A
R
D
V
Q
K
H
M
E
R
Q
L
W
H
W
L
E
K
T
H
S
M
LRPLEASARG
Q
V
Q
V
M
E
R
A
T
V
AATAATA
A
P
A
V
V
V
K
A
V
A
V
TLP
P
Y
R
E
HAHDASEDEDISW
S
R
A
QLV
P
S
V
S
L
A
L
W
E
Q
R
R
R
Q
L
R
H
V
A
G
V
V
D
V
Y
T
L
A
S
M
L
R
D
TREGSPRKRHGSSG
G
A
V
R
F
C
T
S
F
LGSSCDTTASGRVPMPVL
D
A
D
E
L
R
EQG
W
A
L
D
V
V
VKQP
T
Q
Q
Q
H
HQSGSRGRSSSGASPLPH
P
T
V
F
L
F
A
R
D
YI
D
H
A
E
V
L
W
N
L
V
Q
E
RWGRERL
P
V
T
V
MPTWV
N
T
A
A
VFGSDDP
Q
V
E
A
-----
T
---
A
A
SAL
T
D
D
A
L
---
E
K
---
L
-----------
R
-------
R
H
I
G
R
W
L
KGASA----
A
----
D
---------
K
----
T
K
K
R
VAGQ
A
A
A
L
A
I
DTY
G
A
A
V
A
A
A
VASD---EQALTAH
D
A
A
D
I
T
W
G
V
C
T
A
L
A
R
L
H
R
AGLAHGNLKPN
N
V
L
I
AQPVDGRS
A
A
Q
A
E
QAP
R
E
V
HV
T
D
H
L
L
PLL
P
D
QLVEP
G
E
L
L
KLP
W
A
A
A
VAVGGA
P
A
E
RRKSMPVTMS
G
-------------
Y
V
C
L
K
Q
H
E
E
A
ASM
S
Y
LCGGGL
S
D
A
V
AA
P
A
F
S
L
S
G
F
I
L
S
KAVSGND
D
A
A
V
L
E
G
G
V
D
C
L
S
N
T
A
Y
E
A
V
L
L
Q
HLTAP
E
R
V
L
L
V
A
VDSSTVN------AGVR
K
D
A
A
E
VGTA---LST--------GGP
H
F
R
V
----
W
V
DTQHAT
P
A
S
D
I
Y
A
L
G
V
L
L
Y
I
M
L
I
GRLPPLP----
R
Y
R
RASRGTF
S
A
A
AVGA
R
P
Q
R
M
Y
E
A
V
V
N
D
V
---
V
C
A
L
Y
E
N
AARHSFKCDPS
P
M
M
D
E
L
K
A
F
L
Q
S
A
A
A----REH
L
P
L
V
L
A
L
A
RAGVRP
T
T
M
D
I
L
V
G
M
LHV
N
P
A
K
R
L
S
L
A
Q
L
Q
H
H
A
F
F
R
T
YGRRR
H
T
L
R
A
E
F
A
E
A
A
R
R
V
Q
H
AAPVMRKDPL
G
H
S
V
A
A
A
V
G
R
RMMPQNMGASA
K
A
AAEHPRSPPTPSAG
H
L
A
TVAPRV
P
S
M
A
S
M
P
S
R
I
NERGTPDPVLSPASPN
A
A
AASRSASMASVGSAGEEAPRSTPRSP
P
P
Q
L
LRAP
H
A
V
Y
L
PYKRRETTISPPSPSPTLP
A
Q
E
G
E
R
R
QRKEP
S
C
S
L
L
Q
SRALQLSAPSCMGQTHYDLP
R
R
RASIQDDMDR
P
L
D
R
S
C
R
S
L
I
T
A
V
SNRSV
G
A
A
L
I
P
H
A
V
R
R
LSPLGH
E
A
S
V
L
SQTSLDAT
P
A
A
RLGKAGPALHAPR
R
P
V
M
R
R
QSAWMMPHR
Y
S
V
Y
V
V
S
L
A
L
L
F
V
V
R
L
R
R
R
R
E
R
T
W
L
L
G
R
M
R
R
CQR
39
HHSearch
77.92
20%
0
- C- -
-
4PDP
-
?
B:
[191-473]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
I
F
K
D
F
S
-----
I
I
D
E
V
V
G
Q
---
A
T
V
K
K
A
I
E
R
T
T
G
K
T
F
S
V
K
I
I
S
K
--------------
D
G
V
T
R
E
L
---
E
V
---
L
Q
K
LN-------
H
-------
P
R
I
V
R
L
K
G
F
Y
------
E
----
D
---------------
S
Y
Y
M
V
M
E
F
V
S
------
G
G
D
L
M
D
F
V
A
-
A
---
H
G
A
V
G
E
D
A
G
R
E
I
S
R
Q
I
L
T
A
I
K
Y
I
H
S
M
G
I
S
H
R
D
L
K
P
D
N
I
L
I
E
Q
D
D
-----------
P
V
L
V
K
I
T
A
F
G
L
A
K
V
Q
--------------------------------------------------------------------------------------------------------------------
T
L
A
Y
V
A
P
E
V
I
-----------------------------------------------------------
N
E
Y
S
S
L
V
D
M
W
S
M
G
C
L
V
Y
V
I
L
T
G
H
L
P
F
S
G
----
S
T
Q
-------------------------------
D
Q
L
Y
K
Q
I
G
R
G
S
Y
H
E
G
P
-----------------------------
L
K
D
F
R
I
S
E
E
A
R
D
F
I
D
S
L
L
Q
V
D
P
N
N
R
S
T
A
A
K
A
L
N
H
P
W
I
K
M
S
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
HHSearch
73.94
18%
0
- C- -
-
2WEL
7
KCC2D_HUMAN
A:
[2-272]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
T
D
E
Y
-----
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
K
LS---
A
---
R
D
H
Q
K
L
E
R
E
A
---
R
I
---
C
R
L
LK-------
H
-------
P
N
I
V
R
L
H
D
S
I
------
S
----
E
---------
E
----
G
F
H
Y
L
V
F
D
L
V
T
G
------
G
E
L
F
E
D
I
-
V
A
---
R
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
----------
K
G
A
A
V
K
L
A
D
F
G
L
A
I
E
V
Q
G
D
----
Q
----------------------------------------------------------------------------------------------------
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
---------------------------------------------------------
K
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
----
E
D
Q
H
-------------------------------
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
-----------------------------
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
C
Q
R
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
69.29
18%
-16
* C2 *
-
5BYZ
7
MK07_HUMAN
A:
[4-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
G
D
E
Y
-----
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
R
L
T
G
Q
Q
V
A
I
K
K
I
P
N
A
F
DV---
V
---
T
N
A
K
R
T
L
R
E
L
---
K
I
---
L
K
H
F--------
K
H------
D
N
I
I
A
I
K
D
I
L
R
P
TVPY
G
----
E
---------
F
----
K
S
V
Y
V
V
L
D
L
M
E
S
-------
D
L
H
Q
I
I
H
-
S
---
S
Q
P
L
T
L
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
E
N
-------------
C
E
L
K
I
G
D
F
G
M
A
R
G
L
C
T
S
P
A
E
----------------------------------------------------------------------------------------------------
H
Q
Y
F
M
T
E
Y
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
--------------------------------------------------------
L
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
R
R
Q
L
F
P
G
-----
K
N
Y
V
H
Q
L
Q
L
I
M
M
V
L
G
T
P
S
P
A
V
I
Q
A
V
G
A
E
R
---
V
R
A
Y
I
Q
S
L
P
P
R
Q
-----------------------------
P
V
P
W
E
T
V
Y
P
G
A
D
R
Q
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
Y
H
D
P
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
HHSearch
66.53
13%
0
- C- -
-
3EB0
3
?
A:
[6-348]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
K
Y
-----
S
L
G
K
T
L
G
T
G
-
F
G
I
V
C
E
V
F
D
I
E
S
G
K
R
F
A
L
K
K
V
L
Q
D
P
-----
R
---
Y
-
K
N
R
E
L
D
I
M
---
K
V
---
L
D----------
H
-------
V
N
I
I
K
L
V
D
Y
F
Y
T
T------------------
N
----
K
Y
L
N
V
I
M
E
Y
V
P
D
T
L
H
K
V
---
L
K
S
-
F
I
R
S
---
G
R
S
I
P
M
N
L
I
S
I
Y
I
Y
Q
L
F
R
A
V
G
F
I
H
S
L
G
I
C
H
R
D
I
K
P
Q
N
L
L
V
N
S
K
D
------------
N
T
L
K
L
C
D
F
G
S
A
K
K
L
I
P
----
S
-----------------------------------------------------------------------------------------------------
E
P
S
V
A
Y
I
C
S
R
F
Y
R
A
P
E
L
M
L
G
--------------------------------------------------------
A
T
E
Y
T
P
S
I
D
L
W
S
I
G
C
V
F
G
E
L
I
L
G
K
P
L
F
S
G
-----
E
T
S
I
D
Q
L
V
R
I
I
Q
I
M
G
T
P
T
K
E
Q
M
I
R
M
N
--------
P
H
Y
--
V
---
R
F
P
T
L
K
---
A
K
D
W
-------------
R
K
-------
I
L
P
E
G
T
P
S
L
A
I
D
L
L
E
Q
I
L
R
Y
E
P
D
L
R
I
N
P
Y
E
A
M
A
H
P
F
F
D
H
L
R
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
HHSearch
65.55
20%
-56
- C2 -
-
2QR8
-
A:
[19-285]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
T
D
G
Y
-----
E
V
K
E
D
I
G
V
G
S
Y
S
V
C
K
R
C
I
H
K
A
T
N
M
E
F
A
V
K
I
I
D
K
S
K
-----
R
---
D
P
T
E
E
I
E
I
L
L
---
R
Y
---
G
Q----------
H
-------
P
N
I
I
T
L
K
D
V
Y
------
D
----
D
---------
G
----
K
Y
V
Y
V
V
T
E
L
M
K
G
------
G
E
L
L
D
K
I
L
-
R
---
Q
K
F
F
S
E
R
E
A
S
A
V
L
F
T
I
T
K
T
V
E
Y
L
H
A
Q
G
V
V
H
R
D
L
K
P
S
N
I
L
Y
V
D
E
S
G
---------
N
P
E
S
I
R
I
C
D
F
G
F
A
K
Q
L
R
A
E
--------------------------------------------------------------------------------------------------------
N
G
L
L
M
T
P
C
Y
T
A
N
F
V
A
P
E
V
L
E
---------------------------------------------------------
R
Q
G
Y
D
A
A
C
D
I
W
S
L
G
V
L
L
Y
T
M
L
T
G
Y
T
P
F
A
N
----
G
P
D
D
-------------------------
T
---
P
E
E
I
L
A
R
I
G
S
G
K
F
S
L
S
G
-----------------------------
G
Y
W
N
S
V
S
D
T
A
K
D
L
V
S
K
M
L
H
V
D
P
H
Q
R
L
T
A
A
L
V
L
R
H
P
W
I
V
H
W
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
HHSearch
63.13
16%
-23
- C2 -
-
5LXC
9
DYRK2_HUMAN
A:
[73-392]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
V
A
Y
R
Y
-----
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
H
K
V
H
Q
H
V
A
L
K
M
V
R
N
E
K
R
F
---
H
---
R
Q
A
A
E
E
I
R
I
L
---
E
H
---
L
-----------
R
K
Q
D
K
DNT
M
N
V
I
H
M
L
E
N
F
------
T
----
F
---------
R
----
N
H
I
C
M
T
F
E
L
L
S
M
N
-------
L
Y
E
L
I
K
K
N
K--
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
H
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
K
Q
Q
G
-----------
R
S
G
I
K
V
I
D
F
G
S
S
C
Y
E
H
-----------------------------------------------------------------------------------------------------------
Q
R
V
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
---------------------------------------------------------
G
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
-----
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
D
A
S
K
R
A
K
N
F
V
S
S
K
G
Y
P
R
Y
C
T
V
T
T
L
S
D
G
----
S
V
V
L
N
G
G
R
S
R
R
G
K
L
R
G
P
P
E
S
R
E
W
G
N
A
L
K
G
C
D
D
P
L
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
62.03
14%
-31
- C2 -
-
1J1B
1
GSK3B_HUMAN
B:
[57-345]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
K
---------
R
F
K
N
R
E
L
Q
I
M
---
R
K
---
L
-----------
D
H------
C
N
I
V
R
L
R
Y
F
F
Y
S
----
S
GEKK
D
---------
E
----
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
---
A
-
R
H
Y
S
R
A
---
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
------------
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
----
G
-----------------------------------------------------------------------------------------------------
E
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
--------------------------------------------------------
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
-----
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
N
Y
---
T
E
F
K
F
P
Q
I
K
A
H
P
W
-------------------------------
T
K
V
F
R
P
R
T
P
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
61.33
19%
-45
- C2 -
-
4NIF
-
KS6A1_HUMAN
A:
[6-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
D
G
Y
-----
V
V
K
E
T
I
G
V
G
S
Y
S
E
C
K
R
C
V
H
K
A
T
N
M
E
Y
A
V
K
V
I
D
K
S
K
-----
R
---
D
P
S
E
E
I
E
I
L
L
---
R
Y
---
G
Q----------
H
-------
P
N
I
I
T
L
K
D
V
Y
------
D
----
D
---------
G
----
K
H
V
Y
L
V
T
E
L
M
R
G
------
G
E
L
L
D
K
I
L
-
R
---
Q
K
F
F
S
E
R
E
A
S
F
V
L
H
T
I
G
K
T
V
E
Y
L
H
S
Q
G
V
V
H
R
D
L
K
P
S
N
I
L
Y
V
D
E
S
G
---------
N
P
E
C
L
R
I
C
D
F
G
F
A
K
Q
L
R
A
E
----
N
----------------------------------------------------------------------------------------------------
G
L
L
M
T
P
C
Y
---
F
V
A
P
E
V
L
K
---------------------------------------------------------
R
Q
G
Y
D
E
G
C
D
I
W
S
L
G
I
L
L
Y
T
M
L
A
G
Y
T
P
F
A
N
----
G
P
S
D
-------------------------
T
---
P
E
E
I
L
T
R
I
G
S
G
K
F
T
L
S
G
-----------------------------
G
N
W
N
T
V
S
E
T
A
K
D
L
V
S
K
M
L
H
V
D
P
H
Q
R
L
T
A
K
Q
V
L
Q
H
P
W
V
T
Q
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
HHSearch
61.02
19%
-22
- C2 -
-
3C0G
1
CSKP_HUMAN
B:
[19-295]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
L
F
E
D
V
Y
-----
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
SP
G
---
L
S
T
E
D
L
K
R
E
A
---
S
I
---
C
H
M
LK-------
H
-------
P
H
I
V
E
L
L
E
T
Y
------
S
----
S
---------
D
----
G
M
L
Y
M
V
F
E
F
M
D
G
------
A
D
L
C
F
E
I
V
K
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
E
----------
N
S
A
P
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
S
----
G
----------------------------------------------------------------------------------------------------
L
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
---------------------------------------------------------
R
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
----
T
K
E
--------------------------------
R
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
-----------------------------
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
HHSearch
60.50
19%
-23
- C2 -
-
3C0I
1
CSKP_HUMAN
A:
[20-295]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
F
E
D
V
Y
-----
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
SP
G
---
L
S
T
E
D
L
K
R
E
A
---
S
I
C
H
M
L
K----------
H
-------
P
H
I
V
E
L
L
E
T
Y
------
S
----
S
---------
D
----
G
M
L
Y
M
V
F
E
F
M
D
G
------
A
D
L
C
F
E
I
V
K
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
E
----------
N
S
A
P
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
S
----
G
----------------------------------------------------------------------------------------------------
L
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
---------------------------------------------------------
R
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
----
T
K
E
--------------------------------
R
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
-----------------------------
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
60.47
16%
-21
- C2 -
-
1UA2
1
CDK7_HUMAN
D:
[13-298]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
L
D
F
L
G
E
G
Q
F
A
T
V
Y
K
A
R
D
K
N
T
N
Q
I
V
A
I
K
K
I
---------------
N
R
T
A
L
R
E
I
---
K
L
---
L
QELS-------
H
-------
P
N
I
I
G
L
L
D
A
F
------
G
----
H
---------
K
----
S
N
I
S
L
V
F
D
F
M
E
T
D
-------
L
E
V
I
I
K
D
N
---
S
L
V
L
T
P
S
H
I
K
A
Y
M
L
M
T
L
Q
G
L
E
Y
L
H
Q
H
W
I
L
H
R
D
L
K
P
N
N
L
L
L
D
E
N
-------------
G
V
L
K
L
A
D
F
G
L
A
K
S
F
G
S
----
P
N
----------------------------------------------------------------------------------------------------
R
A
Y
T
H
Q
V
V
T
R
W
Y
R
A
P
E
L
L
F
G
--------------------------------------------------------
A
R
M
Y
G
V
G
V
D
M
W
A
V
G
C
I
L
A
E
L
L
L
R
V
P
F
L
P
-----
G
D
S
D
L
D
Q
L
T
R
I
F
E
T
L
G
T
P
T
E
E
Q
W
P
D
M
C
S
L
P
-----
D
Y
V
T
------
F
K
S
F
P
----------------------
G
I
P
L
--
H
H
I
F
S
A
A
G
D
D
L
L
D
L
I
Q
G
L
F
L
F
N
P
C
A
R
I
T
A
T
Q
A
L
K
M
K
Y
F
S
N
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
Fugue
59.83
13%
2
- C2 -
-
1KOB
1
?
A:
[23-374]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
N
D
Y
D
K
F
Y
E
D
I
W
K
K
Y
V
P
Q
P
V
E
V
K
Q
G
S
V
Y
D
Y
Y
D
I
L
E
E
L
G
S
G
A
F
G
V
V
H
R
C
V
E
K
A
T
G
R
V
F
V
A
K
F
I
N
T
P
Y
P
L
D
K
Y
T
V
K
N
E
I
S
I
M
N
Q
L
HHPKLINLH
D
A
F
E
D
K
Y
E
M
V
L
I
L
E
F
L
S
G
G
E
L
F
D
R
I
A
A
E
D
Y
K
M
S
---------
E
A
E
V
I
N
Y
M
R
Q
A
C
E
G
L
K
H
M
H
E
H
S
I
V
H
L
D
I
K
-
P
E
N
I
M
C
E
T
K
K
A
S
S
V
K
IIDFGL
A
T
K
L
N
P
D
E
I
V
K
V
T
---
T
A
T
--------
A
E
F
A
A
P
E
----
I
V
D
R
E
P
V
G
F
Y
T
D
M
W
A
I
G
V
L
G
Y
V
L
L
S
G
L
S
P
F
A
G
----
E
D
D
L
E
T
L
Q
N
V
K
R
C
D
W
E
F
D
E
D
A
F
----------------------------
S
S
V
S
P
E
A
K
D
F
I
K
N
--------------------------------
L
L
Q
K
E
P
R
K
R
L
T
V
H
D
A
L
E
H
P
W
L
K
G
D
H
S
N
L
T
S
R
I
P
S
S
R
Y
N
K
I
R
Q
K
I
K
E
K
Y
A
D
W
P
A
P
Q
P
A
I
G
R
I
A
N
F
S
S
L
R
K
H
R
P
Q
E
Y
Q
I
Y
D
S
Y
F
D
R
K
E
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
59.19
14%
-34
- C2 -
-
4E7W
-
?
A:
[33-327]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
R
E
I
A
Y
-----
T
N
C
K
V
I
G
N
G
S
F
G
V
V
F
Q
A
K
L
V
E
S
D
E
V
A
I
K
K
V
L
Q
D
K
R
----------
F
K
N
R
E
L
Q
I
M
---
R
I
---
V
K----------
H
-------
P
N
V
V
D
L
K
A
F
F
Y
S
----
N
----
G
---------
D
KKD
E
V
F
L
N
L
V
L
E
Y
V
P
E
T
V
Y
R
A
--
S
-
R
-
H
Y
A
K
L
---
K
Q
T
M
P
M
L
L
I
K
L
Y
M
Y
Q
L
L
R
S
L
A
Y
I
H
S
I
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
P
S
------------
G
V
L
K
L
I
D
F
G
S
A
K
I
L
I
A
----
G
-----------------------------------------------------------------------------------------------------
E
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
--------------------------------------------------------
A
T
N
Y
T
T
N
I
D
I
W
S
T
G
C
V
M
A
E
L
M
Q
G
Q
P
L
F
P
G
-----
E
S
G
I
D
Q
L
V
E
I
I
K
V
L
G
T
P
S
R
E
Q
I
K
T
M
N
P
N
Y
---
M
E
H
K
F
P
Q
I
R
P
H
------------------------------
P
-
F
S
K
V
F
R
P
R
T
P
P
D
A
I
D
L
I
S
R
L
L
E
Y
T
P
S
A
R
L
T
A
I
E
A
L
C
H
P
F
F
D
E
L
R
T
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
HHSearch
56.27
17%
-10
- C2 -
-
3BYV
3
?
A:
[76-370]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
R
G
T
V
L
G
Q
E
D
P
Y
A
Y
L
E
A
T
D
-
E
T
G
E
S
F
E
V
H
V
P
Y
F
T
E
PP---
S
N
A
I
K
Q
M
K
E
E
V
L
R
L
---
R
L
---
L
RGIKN
Q
K
Q
A
K
V
H
-------
L
R
F
I
F
P
F
D
L
V
K
D
----
P
----
Q
KKKMIRVMW
V
----
L
S
R
F
F
L
Y
P
R
M
Q
S
N
L
Q
T
F
G
E
V
L
L
S
H
S
S
-
T
---
H
K
S
L
V
H
H
A
R
L
Q
L
T
L
Q
V
I
R
L
L
A
S
L
H
H
Y
G
L
V
H
T
Y
L
R
P
V
D
I
V
L
D
Q
R
-------------
G
G
V
F
L
T
G
F
E
H
L
V
R
D
G
A
------------------------------------------------------------------------------------------------------------
R
V
V
S
S
V
S
R
G
F
E
P
P
E
L
E
A
R
R
A
----
T
I
S
------
Y
H
------------------------------------
R
D
R
R
T
L
M
T
F
S
F
D
A
W
A
L
G
L
V
I
Y
W
I
W
C
A
D
L
P
I
-----------------------------------------
G
G
S
E
W
I
F
R
-------------------------------------
S
C
K
N
I
P
Q
P
V
R
A
L
L
E
G
F
L
R
Y
P
K
E
D
R
L
L
P
L
Q
A
M
E
T
P
E
Y
E
Q
L
R
T
E
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
54.44
14%
-9
- C2 -
-
2X4F
4
MYLK4_HUMAN
A:
[92-352]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
T
E
I
L
G
-----
Q
V
H
K
C
E
E
T
A
T
G
L
K
L
A
A
K
I
I
K
T
R
G
-----
M
---
K
D
K
E
E
V
K
N
E
I
---
S
V
---
M
N
Q
LD-------
H
-------
A
N
L
I
Q
L
Y
D
A
F
------
E
----
S
---------
K
----
N
D
I
V
L
V
M
E
Y
V
D
------
G
G
E
L
F
D
R
I
I
D
E
---
S
Y
N
L
T
E
L
D
T
I
L
F
M
K
Q
I
C
E
G
I
R
H
M
H
Q
M
Y
I
L
H
L
D
L
K
P
E
N
I
L
C
V
N
R
D
-----------
A
K
Q
I
K
I
I
D
F
G
L
A
R
R
Y
K
P
----
R
-----------------------------------------------------------------------------------------------------
E
K
L
K
V
N
F
G
T
P
E
F
L
A
P
E
V
V
N
---------------------------------------------------------
Y
D
F
V
S
F
P
T
D
M
W
S
V
G
V
I
A
Y
M
L
L
S
G
L
S
P
F
L
G
----
D
N
D
A
-------------------------------
E
T
L
N
N
I
L
A
C
R
W
D
L
E
D
-----------------------------
E
E
F
Q
D
I
S
E
E
A
K
E
F
I
S
K
L
L
I
K
E
K
S
W
R
I
S
A
S
E
A
L
K
H
P
W
L
S
D
H
K
L
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
HHSearch
54.31
15%
-17
- C2 -
-
5J5T
1
M4K3_HUMAN
A:
[4-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
F
-----
E
L
I
Q
R
I
G
S
G
T
Y
G
D
V
Y
K
A
R
N
V
N
T
G
E
L
A
A
I
K
V
I
K
L
E
P
-----
G
---
E
D
F
A
V
V
Q
Q
E
I
I
M
M
K
D
---
C
K----------
H
-------
P
N
I
V
A
Y
F
G
S
Y
------
L
----
R
---------
R
----
D
K
L
W
I
C
M
E
F
C
G
G
------
G
S
L
Q
D
I
Y
-
H
V
---
T
G
P
L
S
E
L
Q
I
A
Y
V
S
R
E
T
L
Q
G
L
Y
Y
L
H
S
K
G
K
M
H
R
D
I
K
G
A
N
I
L
L
T
D
N
-------------
G
H
V
K
L
A
D
F
G
V
S
A
Q
I
T
A
T
--------------------------------------------------------------------------------------------------------
I
A
---
A
F
I
G
T
P
Y
W
M
A
P
E
V
A
A
V
E
------------------------------------------------------
R
K
G
G
Y
N
Q
L
C
D
L
W
A
V
G
I
T
A
I
E
L
A
E
L
Q
P
P
M
F
D
----
L
H
P
M
-
R
------------------------------
A
L
F
L
M
T
K
S
N
F
Q
P
P
K
----------------------------
L
K
D
K
M
K
W
S
N
S
F
H
H
F
V
K
M
A
L
T
K
N
P
K
K
R
P
T
A
E
K
L
L
Q
H
P
F
V
T
Q
H
L
T
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
54.29
16%
-26
- C2 -
-
1TKI
-
TITIN_HUMAN
A:
[19-283]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
Y
E
K
Y
-----
M
I
A
E
D
L
G
R
G
E
F
G
I
V
H
R
C
V
E
T
S
S
K
K
T
Y
M
A
K
F
V
K
V
K
G
T
D
---
Q
---
V
L
V
K
K
E
I
S
I
L
---
N
I
---
A
-----------
R
H------
R
N
I
L
H
L
H
E
S
F
------
E
----
S
---------
M
----
E
E
L
V
M
I
F
E
F
I
S
G
------
L
D
I
F
E
R
I
N
T
S
---
A
F
E
L
N
E
R
E
I
V
S
Y
V
H
Q
V
C
E
A
L
Q
F
L
H
S
H
N
I
G
H
F
D
I
R
P
E
N
I
I
Y
Q
T
R
R
-----------
S
S
T
I
K
I
I
E
F
G
Q
A
R
Q
L
K
P
----
G
-----------------------------------------------------------------------------------------------------
D
N
F
R
L
L
F
T
A
P
E
Y
Y
A
P
E
V
H
Q
---------------------------------------------------------
H
D
V
V
S
T
A
T
D
M
W
S
L
G
T
L
V
Y
V
L
L
S
G
I
N
P
F
L
A
----
E
T
N
Q
-------------------------------
Q
I
I
E
N
I
M
N
A
E
Y
T
F
D
E
-----------------------------
E
A
F
K
E
I
S
I
E
A
M
D
F
V
D
R
L
L
V
K
E
R
K
S
R
M
T
A
S
E
A
L
Q
H
P
W
L
K
Q
K
I
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
Fugue
50.94
12%
-36
- C2 -
-
2RIO
1
IRE1_YEAST
A:
[8-434]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
F
E
Q
S
L
K
N
L
V
V
S
E
K
I
L
G
Y
G
S
S
G
T
V
V
F
Q
G
S
F
Q
G
R
P
V
A
V
K
R
M
L
I
D
F
C
D
I
A
L
M
E
I
K
L
L
T
E
S
D
D
H
P
N
V
I
R
Y
Y
C
S
E
T
T
D
R
F
L
Y
I
A
L
E
-----------------------------
L
C
N
L
N
L
Q
D
L
V
E
S
K
---------------
Y
N
P
I
S
L
L
R
Q
I
A
S
G
V
A
H
L
H
S
L
K
I
I
H
R
D
L
K
-
P
Q
N
I
L
V
S
T
S
S
R
F
T
A
D
------
Q
Q
T
G
A
E
N
L
R
I
L
I
S
DFG
L
C
K
K
L
D
STSGW
R
A
P
E
L
L
E
ESNN
L
Q
T
K
R
R
L
T
R
S
I
D
I
F
S
M
G
C
V
F
Y
Y
I
L
S
K
G
K
H
P
F
G
DKYS
R
E
S
N
I
I
R
G
I
F
S
L
D
E
M
K
C
L
H
D
R
S
L
I
A
E
A
T
D
L
---
I
S
Q
M
I
D
H
D
P
L
K
R
------
P
T
A
M
K
V
L
R
H
P
L
F
W
P
K
----
S
K
K
L
E
F
L
L
K
V
S
D
R
L
E
I
E
N
R
D
P
P
S
A
L
L
M
K
F
D
A
G
S
D
F
V
I
P
S
G
D
W
T
V
K
F
D
K
T
F
M
D
R
K
Y
H
S
S
K
L
M
D
L
L
R
A
L
R
N
K
Y
H
H
F
M
D
L
P
E
D
I
A
E
L
M
G
P
V
P
D
G
F
Y
D
Y
F
T
K
R
F
P
N
L
L
I
G
V
Y
M
I
V
K
E
N
L
S
D
D
Q
I
L
R
E
F
L
Y
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
HHSearch
49.70
14%
-6
- C2 -
-
1UNL
1
CDK5_HUMAN
A:
[5-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
L
E
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
R
E
T
H
E
I
V
A
L
K
R
V
R
L
D
D
DD---
E
---
G
V
P
S
S
A
L
R
E
I
---
C
L
L
K
E
L
K----------
H
-------
K
N
I
V
R
L
H
D
V
L
------
H
----
S
---------
D
----
K
K
L
T
L
V
F
E
F
C
D
Q
D
L
-------
K
K
Y
F
D
S
C
---
N
G
D
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
R
N
-------------
G
E
L
K
L
A
N
F
G
L
A
R
A
F
G
I
P
V
--------------------------------------------------------------------------------------------------------
R
C
Y
S
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
--------------------------------------------------------
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
----
G
N
D
V
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
K
-----------
L
P
D
Y
K
P
Y
P
M
Y
P
--
A
T
T
S
L
---------------------
V
N
V
V
P
K
L
N
A
T
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
S
D
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
HHSearch
49.43
17%
-119
- C2 -
-
4JRN
1
?
A:
[197-355]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
F
G
L
V
V
R
M
Y
L
S
S
Q
A
I
K
L
V
A
N
V
Q
A
Q
G
I
V
H
T
D
I
K
P
A
N
F
L
L
L
K
D
-------------
G
R
L
F
L
G
D
F
G
T
Y
R
I
N
N
------------------------------------------------------------------------------------------------------------
S
V
G
R
--
G
T
P
G
Y
E
P
P
E
R
P
----------------------------------------------------------
G
I
T
Y
T
F
P
T
D
A
W
Q
L
G
I
T
L
Y
C
I
W
C
K
E
R
P
T
P
A
----
D
G
I
-------------------
W
D
------------
Y
L
H
F
---------------------------------------
A
D
C
P
S
T
P
E
L
V
Q
D
L
I
R
S
L
L
N
R
D
P
Q
K
R
M
L
P
L
Q
A
L
E
T
A
A
F
K
E
M
D
S
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------