@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_24_0220: (2018-03-10 )
MEGASDKLLREPFRANFKRERSSSYSTERGSPTSPHLRRLRPLPTSSSEGKGAADGDGEEDPHTRRQAEPELFELTPHGGTANTNVRATRFGVEGLRIGRDPSCCDLVLPSNSVSRLHCVLSVLGDDVFVHDNSFNGTFINGRRVGRGRCSVLHPRDTLSFLNPTLEEASRCGFEFAPLPGHSSSAFTAVEGLRRYELGPVLGQGSLAAVRLGIDRETGAPVAIKLIERGRFSCEEAAASLHTEIEMMRSMDHPHVVRVVDAFEGSGCVALVMEYVRGGDLFDYIVGRGRNPFTEAEARHLFGQLLEAILYIHGRSIIHCDLKPENVLVDVVRRGSDGEVDTTSASATATTQGVASSALQTDGDAALSVVDDHQAEAKTVSPYDVRLKLADFGSAKYEGGGAGGGMLETTGAATPVYAAPELACFPADGAPPHEITAVVDVWSLGVLLYILCSGTVPKPPRADAVVAFNRSMTHLSVLCKDLIARMMTVDPSQRPSLADVCHHPWLDGLTISGAPDRGALGSKDVLSVTAKLSPSFPEAAKPL
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110---------.......120...-----....130.......140.......150.---......160.......170.......180.......190..-.....200.......210.......220.......230---.-----.---.....240.........250........260.......270.......280.......290...--......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.....--..400.......410.......420.......430.......440.......450.....------..460....----.--.-------.-------470------....-------.....480.......490..-----.....500.......510..-------.....520.......530.......540.-----------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MEG
A
S
D
K
L
L
R
E
P
F
R
A
N
F
K
R
ERSSSYSTERGSPTS
P
H
L
R
RLRPLPTSSSEGKGAADGDGEEDPHTRRQAEP
E
L
F
E
LTPHGGTANT
N
V
R
A
T
RFGVEGLRIGRDPS
C
C
D
L
VLPSN---------
S
V
S
R
L
H
C
V
L
S
V
LG-----D
D
V
F
V
HDNSFN
G
T
F
IN
G
R
RVGRGR
C
S
V
L---HP
R
D
T
L
S
F
L
N
P
T
L
E
E
A
S
RCGFEFAPLPGHSS
S
A
F
T
A
V
E
G
L
R
-RYELGPVLGQG
S
L
A
A
V
R
LGIDRETGA
P
V
A
I
K
L
I
ERGRF---
S
-----
C
---
E
E
A
A
A
S
--
L
H
T
E
I
E
M
M
R
SM-DHP
H
V
V
R
V
V
DAFEGS
G
C
V
A
L
V
M
E
Y
VRGG
D
L
F
D
Y
I
VGRGR--NPF--
T
E
A
E
A
R
H
L
F
G
Q
L
L
E
A
I
L
Y
IHG
R
S
I
I
H
CDLKP
E
N
V
L
V
D
V
V
RRGSDGEVDTTSASATATTQ
G
V
A
S
S
ALQTDGD
A
A
L
S
V
VDDHQAEAKTVSP
Y
D
V
R
L
K
L
ADFGSAKY--EGGGAGGGMLETTGAATPVYAAP
E
L
A
C
FPADGAPP
H
E
I
T
A
V
V
D
V
W
S
L
G
V
L
L
Y
I
LCSGTVP------KPPRA
D
A
V
V
----
A
--F-------N-------R--------S
M
T
H
-------
L
S
V
L
C
K
D
L
I
A
R
M
MTVDPSQR-----P
S
L
A
D
V
CHHPWLD
G
L
TISGA-------PDRGALGS
K
D
V
L
S
V
TAKLSPSFPEAAKPL-----------------------------
21
HHSearch
75.93
29%
-33
- C1 -
-
3I6U
-
CHK2_HUMAN
A:
[92-493]
----------------------------------------------------------------------
P
W
A
R
L
W
A
L
Q
D
G
----
F
A
N
L
E
C
V
N
D
N
Y
W
F
G
R
D
K
-
S
C
E
Y
C
F
D
E
P
LLKRTDKYR
T
Y
S
K
K
H
F
R
I
F
R
E
V
G
PKN
S
Y
I
A
Y
I
E
D
H
S
G
N
G
T
F
V
N
T
E
L
V
G
K
G
K
R
R
P
L
---
N
N
N
S
E
I
A
L
S
L
S
R
-----
N
K
V
F
V
F
F
D
L
T
V
D
-
D
Q
S
V
Y
P
K
A
L
R
D
-
E
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
R
I
I
S
K
R
K
F
---
A
IG-----------
L
N
--
V
E
T
E
I
E
I
L
K
K
L
-
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
-
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
----
R
L
--
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
-------------------------------------------------
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
--
L
G
---------------
P
T
Y
L
A
P
E
V
L
V
--------
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
------
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
--
T
-------
S
-------
G
KYNFIPE-
V
W
A
E
-------
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
-----
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
------------------------------------------------------------------
33
HHSearch
70.01
29%
-103
- C1 -
-
1KOB
1
?
A:
[48-314]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Y
D
-
Y
Y
D
I
L
E
E
L
G
S
G
A
F
G
V
V
H
R
C
V
E
K
A
T
G
R
V
F
V
A
K
F
I
N
T
P
Y
P
--------------
L
D
K
Y
T
--
V
K
N
E
I
S
I
M
N
Q
L
-
H
H
P
K
L
I
N
L
H
D
A
F
E
D
K
Y
E
M
V
L
I
L
E
F
L
S
G
G
E
L
F
D
R
I
A
A
E
D
---
Y
K
M
--
S
E
A
E
V
I
N
Y
M
R
Q
A
C
E
G
L
K
H
M
H
E
H
S
I
V
H
L
D
I
K
P
E
N
I
M
C
E
T
K
--------------------------------------------------
K
A
S
S
V
K
I
I
D
F
G
L
A
T
K
--
L
N
P
D
E
----
I
V
K
V
T
T
A
T
A
E
F
A
A
P
E
I
V
D
R
E
-------
P
V
G
F
Y
T
D
M
W
A
I
G
V
L
G
Y
V
L
L
S
G
L
S
P
------
F
A
G
E
D
D
L
E
T
L
Q
N
-
V
--
K
-------
R
C
D
W
E
F
DE
D
--------
A
F
S
S
-------
V
S
P
E
A
K
D
F
I
K
N
L
L
Q
K
E
P
R
K
R
-----
L
T
V
H
D
A
L
E
H
P
W
L
K
G
D
H
S
N
-------------------------------------------------------------------
47
Fugue
69.27
23%
-69
- C1 -
-
1KOB
1
?
A:
[23-374]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
N
D
Y
D
K
F
Y
E
D
I
W
K
K
Y
V
P
Q
P
V
E
V
K
Q
G
S
V
Y
D
-
Y
Y
D
I
L
E
E
L
G
S
G
A
F
G
V
V
H
R
C
V
E
K
A
T
G
R
V
F
V
A
K
F
I
N
T
P
Y
--------------
P
L
D
K
Y
T
--
V
K
N
E
I
S
I
M
N
Q
L
-
H
H
P
K
L
I
N
L
H
D
A
F
E
D
K
Y
E
M
V
L
I
L
E
F
L
S
G
G
E
L
F
D
R
I
A
A
E
D
---
Y
K
M
--
S
E
A
E
V
I
N
Y
M
R
Q
A
C
E
G
L
K
H
M
H
E
H
S
I
V
H
L
D
I
K
P
E
N
I
M
C
--------------------------------------------------
E
T
K
K
A
S
S
V
K
I
I
D
F
G
L
A
T
K
--
L
N
P
D
E
I
V
K
V
T
----
T
A
T
A
E
F
A
A
P
E
I
V
-------
D
R
E
P
V
G
F
Y
T
D
M
W
A
I
G
V
L
G
Y
V
L
L
S
G
L
S
P
FA----
G
E
D
D
L
E
T
L
Q
----
N
--
V
-------
K
-------
R
C
D
W
E
F
DED
A
F
S
S
-------
V
S
P
E
A
K
D
F
I
K
N
L
L
Q
K
E
P
R
K
R
-----
L
T
V
H
D
A
L
E
H
P
W
L
K
G
D
H
S
N
L
T
-------
S
R
I
P
S
S
R
Y
N
K
I
R
Q
K
I
K
E
K
Y
A
D
W
P
A
P
Q
P
A
I
GRIANFSSLRKHRPQEYQ
I
Y
D
S
Y
F
DRKEA
45
HHSearch
67.72
32%
-114
- C1 -
-
2BDW
-
KCC2D_CAEEL
A:
[9-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
D
-
N
Y
D
V
K
E
E
L
G
K
G
A
F
S
V
V
R
R
C
V
H
K
T
T
G
L
E
F
A
A
K
I
I
N
T
K
K
L
---
S
-----
A
----
R
D
F
Q
K
--
L
E
R
E
A
R
I
C
R
K
L
-
Q
H
P
N
I
V
R
L
H
D
S
I
Q
E
E
S
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
----
F
Y
--
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
I
A
Y
C
H
S
N
G
I
V
H
R
N
L
K
P
E
N
L
L
L
A
S
K
-------------------------------------------------
A
K
G
A
A
V
K
L
A
D
F
G
L
A
I
E
--
V
N
D
S
E
----
A
W
H
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
K
K
D
-------
P
Y
S
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
------
F
W
D
E
D
Q
H
R
L
Y
A
Q
-
I
--
K
-------
A
-------
G
A
Y
D
Y
P
S
P-
E
W
D
T
-------
V
T
P
E
A
K
S
L
I
D
S
M
L
T
V
N
P
K
K
R
-----
I
T
A
D
Q
A
L
K
V
P
W
I
C
N
R
E
---------------------------------------------------------------------
31
HHSearch
66.59
33%
0
- C- -
-
2WEL
7
KCC2D_HUMAN
A:
[3-272]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
D
-
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
K
L
---
S
-----
A
----
R
D
H
Q
K
--
L
E
R
E
A
R
I
C
R
L
L
-
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
----
Y
Y
--
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
-------------------------------------------------
S
K
G
A
A
V
K
L
A
D
F
G
L
A
I
E
--
V
Q
G
D
Q
---
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
D
-------
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
------
F
W
D
E
D
Q
H
R
L
Y
Q
Q
-
I
--
K
-------
A
-------
G
AYDFPSP-
E
W
D
T
-------
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
-----
I
T
A
S
E
A
L
K
H
P
W
I
C
Q
R
S
---------------------------------------------------------------------
23
HHSearch
65.35
30%
-104
- C1 -
-
2X4F
4
MYLK4_HUMAN
A:
[88-353]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
Y
-
T
V
S
K
T
E
I
L
G
-----
Q
V
H
K
C
E
E
T
A
T
G
L
K
L
A
A
K
I
I
K
T
R
G
M
--------------
K
D
K
E
E
--
V
K
N
E
I
S
V
M
N
Q
L
-
D
H
A
N
L
I
Q
L
Y
D
A
F
E
S
K
N
D
I
V
L
V
M
E
Y
V
D
G
G
E
L
F
D
R
I
I
D
E
S
---
Y
N
L
--
T
E
L
D
T
I
L
F
M
K
Q
I
C
E
G
I
R
H
M
H
Q
M
Y
I
L
H
L
D
L
K
P
E
N
I
L
C
V
N
R
--------------------------------------------------
D
A
K
Q
I
K
I
I
D
F
G
L
A
R
R
--
Y
K
P
R
E
----
K
L
K
V
N
F
G
T
P
E
F
L
A
P
E
V
V
N
Y
D
-------
F
V
S
F
P
T
D
M
W
S
V
G
V
I
A
Y
M
L
L
S
G
L
S
P
------
F
L
G
D
N
D
A
E
T
L
N
N
-
I
--
L
-------
A
CRWDLED
E
--------
E
F
Q
D
-------
I
S
E
E
A
K
E
F
I
S
K
L
L
I
K
E
K
S
W
R
-----
I
S
A
S
E
A
L
K
H
P
W
L
S
D
H
K
L
H
S
------------------------------------------------------------------
10
PsiBlast_PDB
65.02
29%
-94
- C- -
-
3FE3
-
MARK3_HUMAN
A:
[56-309]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
R
E
V
A
I
K
I
I
D
K
T
Q
L
---
N
---------
P
T
S
L
Q
K
--
L
F
R
E
V
R
I
M
K
I
L
-
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
I
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
R
----
M
--
K
E
K
E
A
R
S
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
R
I
V
H
R
D
L
K
A
E
N
L
L
L
D
A
----------------------------------------------------
D
M
N
I
K
I
A
D
F
G
---
F
--
S
N
E
F
T
V
G
G
K
L
D
A
F
C
G
A
P
P
-
Y
A
A
P
E
L
F
Q
G
K
K
Y
D
G
P
E
------
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
FDGQN
L
K
E
L
R
E
R
V
L
R
----
G
--
K
-------
Y
-------
R
--------
I
P
F
Y
-------
M
S
T
D
C
E
N
L
L
K
R
F
L
V
L
N
P
I
K
R
-----
G
T
L
E
Q
I
M
K
D
R
W
I
N
A
-----------------------------------------------------------------------
6
PsiBlast_PDB
64.96
29%
-98
- C1 -
-
2QNJ
-
MARK3_HUMAN
A:
[56-309]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
R
E
V
A
I
K
I
I
D
K
T
Q
L
---
N
---------
P
T
S
L
Q
K
--
L
F
R
E
V
R
I
M
K
I
L
-
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
I
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
R
----
M
--
K
E
K
E
A
R
S
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
R
I
V
H
R
D
L
K
A
E
N
L
L
L
D
A
----------------------------------------------------
D
M
N
I
K
I
A
D
F
G
---
F
--
S
N
E
F
T
-----
D
T
F
-
C
G
S
P
P
Y
A
A
P
E
L
F
Q
G
K
K
Y
D
G
P
E
------
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
FDGQN
L
K
E
L
R
E
R
V
L
R
----
G
--
K
-------
Y
-------
R
--------
I
P
F
Y
-------
M
S
T
D
C
E
N
L
L
K
R
F
L
V
L
N
P
I
K
R
-----
G
T
L
E
Q
I
M
K
D
R
W
I
N
A
-----------------------------------------------------------------------
52
Fugue
64.19
21%
-9
- C1 -
-
2ACX
1
GRK6_HUMAN
A:
[14-532]
--------------------------
K
A
R
K
G
K
S
K
K
W
R
Q
M
L
Q
F
P
H
I
S
Q
C
E
E
L
R
L
S
L
E
R
D
Y
H
S
L
C
E
R
N
P
I
G
R
L
L
F
R
E
F
C
A
T
R
P
E
L
S
R
C
V
A
F
L
D
G
V
A
E
Y
E
V
T
P
D
D
K
------
R
K
A
---------
C
G
R
N
L
T
Q
N
F
L
S
H
T
-----
G
P
D
L
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
E
Q
G
P
C
K
D
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
P
V
-
T
K
N
-
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
R
A
T
G
K
M
Y
A
C
K
K
L
E
K
K
R
I
---
K
-----
K
---
R
K
G
E
A
M
--
A
L
N
E
K
Q
I
L
E
K
V
-
N
S
R
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
M
G
Q
--
A
G
F
--
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
E
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
-----
D
H
G
-----------------------------------------------
H
I
R
I
S
D
L
G
L
A
V
H
------
V
P
E
G
Q
T
I
K
G
R
V
G
T
V
G
Y
M
A
P
E
V
V
-------
K
N
E
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
FQQ---
R
K
K
K
I
K
R
E
E
----
V
--
E
-------
R
-------
L
--------
V
K
E
V
P
E
E
Y
S
ER
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
LGCRG
G
S
A
R
E
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
GMLEP
P
F
K
P
D
P
Q
A
I
Y
C
E
P
T
D
Q
D
F
Y
Q
K
F
A
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
E
C
F
Q
E
L
N
VFGLDGS------
12
PsiBlast_PDB
63.89
28%
-76
- C1 -
-
3I6W
-
CHK2_HUMAN
A:
[159-486]
----------------------------------------------------------------------------------------------------------------------------------------------
Y
I
E
D
H
S
G
N
G
T
F
V
N
T
E
L
V
G
K
G
K
R
R
P
L
---
N
N
N
S
E
I
A
-----
L
S
L
S
R
N
K
V
F
V
F
F
D
L
T
V
D
D
Q
S
V
Y
P
--
K
A
L
R
D
E
Y
I
M
S
K
T
L
G
-----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
R
I
I
S
K
--------------------
L
N
--
V
E
T
E
I
E
I
L
K
K
L
-
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
-
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
----
L
--
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
------------------------------------------
S
S
Q
E
E
-------
D
C
L
I
K
I
T
D
F
------------------------
P
T
Y
L
A
P
E
V
L
V
----
A
G
----
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
FSEHRT
Q
V
S
L
K
D
Q
I
T
----
S
GK
Y
-------
N
FIP----
E
--------
V
W
A
E
-------
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
-----
F
T
T
E
E
A
L
R
H
P
W
L
-------------------------------------------------------------------------
18
PsiBlast_PDB
63.86
30%
-54
- C1 -
-
3MFU
1
CSKP_HUMAN
A:
[26-290]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
L
C
E
V
I
G
K
G
A
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
---
T
-----
S
---
S
P
G
L
S
T
E
D
L
K
R
E
A
S
I
C
H
M
L
-
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
--
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
E
N
V
L
L
---------------------------------------------
A
S
K
E
N
S
A
P
----
V
K
L
G
D
F
G
V
A
I
Q
L
G
E
S
G
L
V
A
G
G
R
V
-----
G
T
P
H
F
M
A
P
E
V
V
K
R
E
P
Y
G
K
P
-------
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
FYGT--
K
E
R
L
F
E
G
I
I
----
K
--
G
-------
K
YKMNP--
R
--------
Q
W
S
H
-------
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
-----
I
T
V
Y
E
A
L
N
H
P
W
L
-------------------------------------------------------------------------
39
HHSearch
63.52
32%
-23
- C1 -
-
2Y7J
1
PHKG2_HUMAN
D:
[91-364]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
Y
Q
-
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
V
------
R
LSPEQ
L
---
E
E
V
R
E
A
--
T
R
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
V
----
A
L
--
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
D
D
----------------------------------------------------
N
M
Q
I
R
L
S
D
F
G
F
S
C
H
--
L
E
P
G
E
----
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
C
S
M
D
-
E
T
H
P
G
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
------
F
W
H
R
R
Q
I
L
M
LRM-
I
--
M
-------
E
-------
G
QYQFSSP-
E
W
D
D
-------
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
-----
L
T
A
E
Q
A
L
Q
H
P
F
F
E
------------------------------------------------------------------------
36
HHSearch
63.48
32%
-21
* C1 *
-
2Y7J
1
PHKG2_HUMAN
C:
[91-364]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
Y
Q
-
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
V
T
A
E
---
R
LSPEQ
L
---
E
E
V
R
E
A
--
T
R
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
V
----
A
L
--
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
D
D
----------------------------------------------------
N
M
Q
I
R
L
S
D
F
G
F
S
C
H
--
L
E
P
G
E
----
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
C
S
M
D
-
E
T
H
P
G
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
------
F
W
H
R
R
Q
I
L
M
LRM-
I
--
M
-------
E
-------
G
QYQFSSP-
E
W
D
D
-------
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
-----
L
T
A
E
Q
A
L
Q
H
P
F
F
E
------------------------------------------------------------------------
16
PsiBlast_PDB
63.08
30%
-49
- C1 -
-
3MFS
1
CSKP_HUMAN
A:
[26-290]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
L
C
E
V
I
G
K
G
A
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
---
T
-----
S
---
S
P
G
L
S
T
E
D
L
K
R
E
A
S
I
C
H
M
L
-
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
--
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
E
N
V
L
L
---------------------------------------------
A
S
K
E
N
S
A
P
----
V
K
L
G
D
F
G
V
A
I
Q
L
G
E
S
G
L
V
A
G
G
R
V
-----
G
T
P
H
F
M
A
P
E
V
V
K
R
E
P
Y
G
K
P
-------
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
FYGT--
K
E
R
L
F
E
G
I
I
----
K
--
G
-------
K
YKMNP--
R
--------
Q
W
S
H
-------
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
-----
I
T
V
Y
E
A
L
N
H
P
W
L
-------------------------------------------------------------------------
8
PsiBlast_PDB
62.33
28%
-114
- C1 -
-
1ZMV
-
MARK2_RAT
A:
[51-305]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-
N
Y
R
L
L
K
T
I
G
K
G
--
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
R
I
I
D
K
T
Q
L
---
N
-----
S
---
S
-
S
L
Q
K
--
L
F
R
E
V
R
I
M
K
V
L
-
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
R
----
M
--
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
D
A
----------------------------------------------------
D
M
N
I
K
I
A
------------------------
G
S
P
P
Y
A
A
P
E
L
F
Q
G
K
K
Y
D
G
P
E
------
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
FDGQN
L
K
E
L
R
E
R
V
L
R
----
G
--
K
-------
Y
-------
R
--------
I
P
F
Y
-------
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
R
-----
G
T
L
E
Q
I
M
K
D
R
W
M
N
------------------------------------------------------------------------
30
HHSearch
62.30
33%
-43
- C1 -
-
3C0I
1
CSKP_HUMAN
A:
[22-295]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
D
-
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
---
T
-----
S
SP-
G
L
S
T
E
D
--
L
K
R
E
A
S
I
C
H
M
L
-
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
A
G
F
V
Y
--
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
-------------------------------------------------
E
N
S
A
P
V
K
L
G
G
F
G
V
A
I
Q
--
L
G
E
S
G
L
---
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
R
E
-------
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
------
F
Y
G
T
K
E
R
L
F
E
G
--
I
--
I
-------
K
-------
G
K
Y
K
M
N
PR-
Q
W
S
H
-------
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
-----
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
R
--------------------------------------------------------------------
15
PsiBlast_PDB
62.29
30%
-50
- C1 -
-
3MFR
1
CSKP_HUMAN
A:
[26-290]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
L
C
E
V
I
G
K
G
A
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
---
T
-----
S
---
S
P
G
L
S
T
E
D
L
K
R
E
A
S
I
C
H
M
L
-
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
--
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
E
N
V
L
L
---------------------------------------------
A
S
K
E
N
S
A
P
----
V
K
L
G
D
F
G
V
A
I
Q
L
G
E
S
G
L
V
A
G
G
R
V
-----
G
T
P
H
F
M
A
P
E
V
V
K
R
E
P
Y
G
K
P
-------
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
FYGT--
K
E
R
L
F
E
G
I
I
----
K
--
G
-------
K
YKMNP--
R
--------
Q
W
S
H
-------
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
-----
I
T
V
Y
E
A
L
N
H
P
W
L
-------------------------------------------------------------------------
3
PsiBlast_PDB
62.13
29%
-104
- C1 -
-
5KZ8
1
MARK2_HUMAN
A:
[35-287]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
I
D
K
T
Q
L
---
N
-----
S
---
S
-
S
L
Q
K
--
L
F
R
E
V
R
I
M
K
V
L
-
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
R
----
M
--
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
D
A
----------------------------------------------------
D
M
N
I
K
I
A
D
F
G
--------------------
C
G
S
P
P
Y
A
A
P
E
L
F
Q
G
K
K
Y
D
G
P
E
------
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
FDGQN
L
K
E
L
R
E
R
V
L
R
----
G
--
K
-------
Y
-------
R
--------
I
P
F
Y
-------
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
R
-----
G
T
L
E
Q
I
M
K
D
R
W
M
N
------------------------------------------------------------------------
42
HHSearch
61.60
31%
-17
- C1 -
-
4B4L
3
DAPK1_HUMAN
A:
[11-282]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
D
-
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
---
K
-----
S
SRR
G
V
S
R
E
D
--
I
E
R
E
V
S
I
L
K
E
I
-
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
----
S
L
--
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
------------------------------------------------
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
--
I
D
F
G
N
----
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
-------
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
------
F
L
G
D
T
K
Q
E
T
L
A
N
-
V
--
S
A
VNYEFE
D
-------
E
--------
Y
F
S
N
-------
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
-----
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
D
T
--------------------------------------------------------------------
14
PsiBlast_PDB
61.40
28%
-37
- C1 -
-
3I6U
-
CHK2_HUMAN
A:
[159-486]
----------------------------------------------------------------------------------------------------------------------------------------------
Y
I
E
D
H
S
G
N
G
T
F
V
N
T
E
L
V
G
K
G
K
R
R
P
L
---
N
N
N
S
E
I
A
-----
L
S
L
S
R
N
K
V
F
V
F
F
D
L
T
V
D
D
Q
S
V
Y
P
--
K
A
L
R
D
E
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
R
I
I
S
K
R
K
F
AIG--------------
L
N
--
V
E
T
E
I
E
I
L
K
K
L
-
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
-
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
----
L
--
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
------------------------------------------
S
S
Q
E
E
-------
D
C
L
I
K
I
T
D
F
G
H
S
K
I
--
L
G
---------------
P
T
Y
L
A
P
E
V
L
V
----
A
G
----
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
RT
Q
V
S
L
K
D
Q
I
T
----
S
GK
Y
-------
N
FIP----
E
--------
V
W
A
E
-------
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
-----
F
T
T
E
E
A
L
R
H
P
W
L
-------------------------------------------------------------------------