@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_24_0680: (2018-03-10 )
MDEVSVLNYLGPHPQIVRFLGSYTTSKNTSFFTMELMDSDVGRELREGNATLHEEGVCAAIAYSVLLALEEMHSHAVAHRDVKPGNILLKRLTEPEEWACIYLPRDDFRARLLPKSSAVSAFDPKLCTSKEASSHEVAPAIRSANDNASYVKAALGDFSAAHSTRCADNVAFFDTRGTLHYKSPEQLMGKRSVVSENFAAVDLWGLGCTLYEMVTGTRPFPGSSELQVLMSILDALGSDIQSFPVATKHAALFDEIPASPAFVNLLQRLLCLDPTRRCTAKEALRHSFLASIRDSALRCADAERQISTDRLPYVIGIPLTLKYASFTHIPELRFSRISRTPLKATESTPSELSAPQQPPANGCPAPPSASDTEIAALTVVAEREAAAETRSKHRDVNHWSDGATTTLWGREGDCEDQEEKETPSKKPPQQHCSDTTGTSFLSESSYLHWSEIRPATRPSAPPLLKPLQHKENRVRSSSGCRAVAFFGNAAVGSTPSPSTSANDPQQQPQSLSGSMHRTVDVASRNTVSRALNISDSSVKGVRTERSASHVDFDLSPVAATQLFSTETDTSACLVPHPAAAFLPRRTQPVLQLASGSTFTASNLRANSSFERENLMVGRCGGNGTSTSAAVGVAGPTGVIHAGRCSTPRQHHGQRPTALSGRALCFSEETDPFTRRSWGSSAGQQSCLNSLLTSPAPVGQRAVEECSPQPSPIRPIGVATRSPSGLPVAADRSGLFLDDSGVGLGWIGMPPTTSAAQESIGAGACEAVAALMPALARDVSRGSEAGAAVAPMLYPVRLQPSWNASSTTATGIVQPSNSPCVRRCVHLLEPPPGGCSRSRTCSAVALTMGVTTAAVAERPDASCSSQQQQPTTSPASTGRRDASSSRIMPLPIPLSVATVCQSAQQSLCAPTPRSRTPTSRALHETPRTQRFSCPTSALRTGYAGHKNGNQRGSSQPQDALTSCVDGGDDILSAAPFLCNQDVNASVTHLAHKVCASVGLTGSGSGAAPTLRCAAASPLGSLVACTHSSQRHCTPSSSDPAPEIAVSINCDGCNHPAVANEASPTPNVTVVRASRAMLSTGGPHTPLPVHGSASPLSQPCDAPLLQLSSASLDSHRRSVKGHESDRIETPQSKRRESMKRAREEAMDSEDVAAVRQSARVV
Atome Classification :
(20 SA)
------------------------------------------------.........10-----......---..20.....-----.----.-----.30.......-.-40.......--.50........60........70........80........90........100......-.110.......120.......130.......140.......150.......160.....--------..170.......180.......190.--......200.......210...-....220...---..-----------...230.--------..-....----------------240.----------------.-...-----------------------------------------..--.-250.-----..-------...--.--.-.260.......270....--...280----.-.......-------.290..-------.....-----300.......310.......320-----.........330.......340.......350......--------.360.......370....--------...380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
------------------------------------------------MDE
V
S
V
L
NYLG-----P
H
P
Q
I
V
---
R
F
L
G
SYTTS-----K----N-----T
S
F
F
T
M
E
L
M
D
-
S
-
D
V
G
R
E
L
R
EG--NATLHEEG
V
C
A
A
I
A
Y
S
V
L
L
A
L
E
E
M
H
S
H
A
V
AHRDVKP
G
N
I
L
L
K
RLTEPE
E
W
A
C
I
Y
LPRD
D
F
-
R
A
RLLPKSSAVSAFDPKLCTSKEASSH
E
V
A
P
A
I
RSAND
N
A
S
Y
V
K
A
A
L
GD
F
S
A
AHSTRCA--------D
N
V
A
F
F
DTRG
T
L
HYK
S
P
E
Q
L
M
G
K
R
S
V
--VSENF
A
A
V
D
LWG
L
G
C
T
L
Y
E
M
VT-GTRPF-PG
S
S
---
E
L
-----------
Q
V
L
M
S
I
L
--------
D
A
-
L
G
S
D
----------------
I
-
Q
S----------------F-PV
A
-----------------------------------------
T
K
--
H
-
A
--
A
-----
L
F
-------
D
EI--P--A-S
P
A
F
V
N
L
L
Q
R
L
LCLDPTR--RC
T
A
------
K
-
E
A
L
R
H
S
F
-------
L
A
S
I
R
D
-------
S
A
L
RC-----A
D
A
ERQISTDRL
P
Y
V
I
GI
P
L
T
-------
L
K
YASFTHIP
E
L
R
F
S
R
ISRTPLKATESTPSELSAPQQP--------PANGCPAPPSASDT
E
I
A
A
--------
L
T
V
V
AE
R
E
A
A
A
E
T
R
S
KHRDVNHWSDGA
T
T
T
L
WGREGDCE
D
Q
E
EKETPSKKP
P
Q
Q
HCSDTTGTSFLSESS
Y
L
H
W
S
EIRPATRPSAPPL
L
K
P
L
Q
H
K
E
N
RVRSSSG
C
R
A
V
A
F
FGNAAVGSTPSPSTSANDPQQ
Q
P
Q
S
LSGSM
H
R
T
V
D
VASRNT
V
S
R
A
LNISDSSVKGVRTERSASHVDFDLSP
V
A
A
T
Q
L
FSTETDTSACLVPH
P
A
A
A
FLPRRT
Q
P
V
L
Q
LASG
S
T
F
T
A
SNLRANSSFERE
N
L
M
V
G
RCGGNGTST
S
A
A
VGVAGPTG
V
I
HAGRCST
P
R
Q
HHGQRPTALSG
R
A
L
C
FSEETDP
F
T
R
RSWGSSA
G
Q
Q
S
C
L
N
S
L
LTSPAP
V
G
Q
R
A
V
E
ECSPQPSPI
R
P
I
GVATRSPSGLPVAADRS
G
L
F
LDDSGV
G
L
GWIGMPPT
T
S
A
A
Q
E
S
IG
A
G
A
C
E
A
V
A
A
L
M
P
A
L
A
R
D
V
SRGSEAGAAVA
P
M
L
Y
P
V
R
LQPSWNASS
T
T
A
T
G
I
VQPSN
S
P
C
V
R
R
C
V
H
LLEPPPGGCSRSR
T
C
S
A
V
A
L
T
MGVT
T
A
A
VAERPDASCSSQQQQPTTSPASTGRRDASSS
R
I
M
PLPIP
L
S
V
A
T
V
C
Q
S
A
Q
Q
S
LCAPTPRSRTP
T
S
R
A
L
HETPRTQRFSC
P
T
S
A
L
RTGYAGHKNGNQRGSSQ
P
Q
D
A
L
T
S
C
VDG
G
D
D
I
L
S
AAPFLCNQDV
N
A
S
V
T
H
L
A
H
K
V
C
A
SVGLTGSGSGAA
P
T
L
R
CAAASP
L
G
S
L
V
A
CTHSSQRHCTPSSSDPA
P
E
I
A
V
S
I
NCDGCNHPAVANEASPTP
N
V
T
V
V
RAS
R
A
M
LSTGGPHTPLPVHGSASPLSQPCDA
P
L
L
Q
L
SSA
S
L
D
S
H
R
R
SVKGHESDRIET
P
Q
S
K
R
R
E
S
M
K
R
A
R
E
EAMD
S
E
D
V
A
A
V
R
Q
SARVV
34
HHSearch
75.92
30%
-110
- C2 -
-
4XBR
1
INKA1_HUMAN (first)
A:
[140-354]
-------------------------------------------------
N
E
V
V
I
M
R
D
Y
------
Q
H
E
N
V
V
---
E
M
Y
N
S
Y
L
V
G
----------
D
-----
E
L
W
V
V
M
E
F
L
E
-
G
-
G
A
L
T
D
I
V
T
H
--
T
--
R
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
-----------------------------------------------------------
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
--------
V
P
-
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
R
L
P
-------
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
-
G
E
P
P
Y
-
F
N
E
P
---
P
L
-----------
K
A
M
K
M
I
R
--------
D
N
-
L
P
-----------------------------------------
P
R
--------------------------------------------------------
L
K
-------
N
L
H
--
K
--
V
-
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
--
R
A
T
A
------
A
-
E
L
L
K
H
P
F
-------
L
A
K
A
G
P
-------
P
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
Fugue
70.16
23%
-20
- C2 -
-
1TKI
-
TITIN_HUMAN
A:
[18-338]
KELYEK
Y
M
I
A
E
DLGRGEF
G
I
V
H
R
C
V
ETSSK
K
T
Y
M
A
K
F
V
KVKG
T
D
Q
V
L
V
K
K
E
I
S
I
L
N
I
A
R
------
H
R
N
I
L
---
H
L
H
E
S
F
E
S
M
-----
E
----
E
-----
L
V
M
I
F
E
F
I
S
G
-
L
-
D
I
F
E
R
I
N
T
S
--
A
F
E
L
-
N
E
R
E
I
V
S
Y
V
H
Q
V
C
E
A
L
Q
F
L
H
S
H
N
I
G
H
F
D
I
R
P
E
N
I
I
Y
Q
-------------------------------------------------------
T
R
R
S
S
T
I
K
I
I
--
E
F
G
Q
A
--
R
Q
L
K
--------
P
G
D
N
F
R
L
L
F
T
A
P
E
Y
Y
A
P
E
V
H
--
Q
H
D
V
--
V
S
---
T
A
T
D
M
W
S
L
G
T
L
V
Y
V
L
L
S
-
G
I
N
P
F
-
L
A
E
T
---
N
Q
-----------
Q
I
I
E
N
I
M
--------
N
A
E
Y
T
F
D
----------------
E
-
E
A
----------------
F
-
K
------------------------------------------------------------------------
E
--
I
-
S
I
E
A
M
D
F
V
D
R
L
L
V
K
E
R
K
S
--
R
M
T
A
------
S
-
E
A
L
Q
H
P
W
-------
L
K
Q
K
I
E
RVSTKVI
R
T
L
K
H
-----
R
R
Y
Y
H
T
L
I
K
K
D
L
N
M
V
V
S
A
A
R
I
-------
S
C
G
G
A
I
R
S
Q
K
G
V
S
V
A
K
V
K
V
A
S
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
HHSearch
67.69
28%
-84
- C2 -
-
1UA2
1
CDK7_HUMAN
D:
[61-298]
-------------------------------------------------
R
E
I
K
L
L
Q
E
L
------
S
H
P
N
I
I
---
G
L
L
D
A
F
G
H
K
----------
S
-----
N
I
S
L
V
F
D
F
M
E
-
T
-
D
L
E
V
I
I
K
D
N
--
S
L
-
V
L
T
P
S
H
I
K
A
Y
M
L
M
T
L
Q
G
L
E
Y
L
H
Q
H
W
I
L
H
R
D
L
K
P
N
N
L
L
L
D
E
N
G
-----------------------------------------------------------
V
L
K
L
A
D
F
G
L
A
K
S
F
G
S
P
--------
N
-
R
A
Y
T
H
Q
V
V
T
R
W
Y
R
A
P
E
L
L
F
G
A
R
------
M
Y
G
V
G
V
D
M
W
A
V
G
C
I
L
A
E
L
L
L
-
R
V
P
F
L
-
P
G
D
S
---
D
L
-----------
D
Q
L
T
R
I
F
--------
E
T
-
L
G
T
P
----------------
T
E
E
Q
----------------
W
-
P
D
M
-----------------------------------------
C
S
--
L
-
P
--
D
YVTFK
S
F
PGIPLHH
I
F
S
--
A
--
A
-
G
D
D
L
L
D
L
I
Q
G
L
F
L
F
N
P
C
A
--
R
I
T
A
------
T
-
Q
A
L
K
M
K
Y
-------
F
S
N
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
67.41
24%
-84
- C2 -
-
5CI6
-
MPK6_ARATH
A:
[113-337]
--------------------------------------------------------------------------------------------
N
-----
D
V
Y
I
A
Y
E
L
M
D
-
T
-
D
L
H
Q
I
I
R
S
---
N
Q
A
L
S
E
E
H
-
C
Q
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
------------------------------
A
N
C
D
L
K
I
C
-----------------------------
D
F
G
L
A
R
V
T
----------------------
R
W
Y
R
A
P
E
L
L
L
N
S
------
S
D
Y
T
A
A
I
D
V
W
S
V
G
C
I
F
M
E
L
M
D
-
R
K
P
L
F
-
P
G
R
D
---
H
V
-----------
H
Q
L
R
L
L
M
--------
E
L
-
I
G
T
P
SEEELEFLN
E
N
A
K
R
Y
-
I
-
R
Q
----------------
L
-
P
P
Y
-----------------------------------------
P
R
--
Q
-
S
--------
I
T
-------
D
K
F
--
P
--
T
V
H
P
L
A
I
D
L
I
E
K
M
L
T
F
D
P
R
R
--
R
I
T
V
------
L
-
D
A
L
A
H
P
Y
-------
L
N
S
L
H
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
67.24
26%
-85
* C2 *
-
4BGQ
3
CDKL5_HUMAN
A:
[60-303]
-------------------------------------------------
R
E
L
K
M
L
R
T
L
------
K
Q
E
N
I
V
---
E
L
K
E
A
F
R
R
------
R
----
G
-----
K
L
Y
L
V
F
E
Y
V
E
-
K
-
N
M
L
E
L
L
E
E
M
--
P
N
-
G
V
P
P
E
K
V
K
S
Y
I
Y
Q
L
I
K
A
I
H
W
C
H
K
N
D
I
V
H
R
D
I
K
P
E
N
L
L
I
S
H
N
D
-----------------------------------------------------------
V
L
K
L
C
D
F
G
F
A
R
N
L
S
E
-------------------
T
R
W
Y
R
S
P
E
L
L
L
G
A
P
-------
Y
G
K
S
V
D
M
W
S
V
G
C
I
L
G
E
L
S
D
-
G
Q
P
L
F
-
P
G
E
S
---
E
I
-----------
D
Q
L
F
T
I
Q
--------
K
V
-
L
G
P
L
----------------
P
-
S
E
Q
M
K
L
F
Y
S
NPRFHGLR-
F
-
P
A
V
-----------------------------------------
N
H
--
P
-
Q
S
L
E
-----
R
R
-------
Y
L
G
--
I
--
L
-
N
S
V
L
L
D
L
M
K
N
L
L
K
L
D
P
A
D
--
R
Y
L
T
------
E
-
Q
C
L
N
H
P
T
-------
F
Q
T
Q
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
66.97
24%
-84
- C2 -
-
4QTB
14
MK03_HUMAN
A:
[120-336]
----------------------------------------------------------------------------------------------------
Y
I
V
Q
D
L
M
E
-
T
-
D
L
Y
K
L
L
K
----
S
Q
Q
L
S
N
D
H
I
C
Y
F
L
-
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
I
N
------------------------------
T
T
C
D
L
K
I
C
---------------------
D
F
G
L
A
R
I
A
D
P
E
H
D
H
T
G
F
L
T
--------
E
Y
V
A
------
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
--
T
K
----
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
-
N
R
P
I
F
-
P
G
K
H
---
Y
L
-----------
D
Q
L
N
H
I
L
--------
G
I
-
L
G
S
P
S
Q
E
D
L
N
C
IIN
M
K
A
R
N
Y
L
-
Q
S
----------------
L
-
P
S
K
-----------------------------------------
T
K
VA
W
-
A
--
K
-----
L
F
-------
P
K
------
S
-
D
S
K
A
L
D
L
L
D
R
M
L
T
F
N
P
N
K
--
R
I
T
V
------
E
-
E
A
L
A
H
P
Y
-------
L
E
Q
Y
Y
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
66.20
27%
-56
- C2 -
-
4RA5
2
KPCT_HUMAN
A:
[55-269]
--------------------------------------------------
E
K
R
V
L
S
L
A
W
-----
E
H
P
F
L
T
---
H
M
F
C
T
F
Q
T
K
----------
E
-----
N
L
F
F
V
M
E
Y
L
N
-
G
G
D
L
M
Y
H
I
Q
S
C
--
H
--
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
K
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
D
G
-----------------------------------------------------------
H
I
K
I
A
D
F
G
M
C
K
E
N
M
L
G
--------
D
A
-
K
T
N
E
F
C
G
T
P
D
Y
I
A
P
E
I
L
L
G
Q
K
-------
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
-
G
Q
S
P
F
-
H
G
Q
D
---
E
E
-----------
E
L
F
H
S
I
R
--------
M
D
-
N
---------------------
P
F
----------------
Y
-
P
---------------------------------------------------------------------
R
--
W
--
L
-
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
--
R
L
G
V
------
R
G
D
I
R
Q
H
P
L
-------
F
R
E
I
N
W
-------
E
E
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
Fugue
66.08
14%
-
- C2 -
-
3QA8
-
?
A:
[16-666]
-------------------------------------------------
E
M
K
E
R
L
G
T
G
G
-----
F
G
Y
V
L
R
WIH
Q
D
T
G
E
Q
V
A
I
-----
K
----
Q
-----
C
R
Q
E
L
S
P
K
N
R
-
E
-
R
W
C
L
E
I
Q
I
M
--
K
K
L
N
H
P
N
V
V
S
A
R
E
V
P
D
G
L
Q
K
L
A
P
N
D
L
P
L
L
A
M
E
Y
C
E
G
G
D
-
L
R
K
Y
L
N
Q
F
E
N
--
C
C
G
L
K
E
G
P
I
-
R
T
L
L
S
D
I
S
S
A
L
R
Y
L
H
E
N
R
I
I
H
R
D
-----
L
K
P
E
N
I
V
L
Q
P
G
P
Q
R
L
I
H
K
I
I
D
L
G
Y
A
K
E
L
D
----------
Q
G
E
L
C
T
E
F
V
G
T
L
Q
Y
L
A
P
E
L
L
E
Q
K
K
Y
T
--
V
T
-----
V
D
Y
W
S
F
G
T
L
A
F
E
C
I
T
-
G
F
R
P
F
L
P
N
W
Q
---
P
V
-----------
Q
W
H
G
K
V
R
--------
I
V
-
V
Y
D
D
----------------
L
-
T
G
----------------
A
-
V
K
F
-----------------------------------------
S
S
--
V
-
L
--
P
-----
T
P
-------
N
H
L
S
G
I
--
L
-
A
G
K
L
E
R
W
L
Q
C
M
L
M
W
H
Q
R
T
--
D
P
Q
N
------
P
-
N
V
G
C
F
Q
A
-------
L
D
S
I
L
S
-------
L
K
L
L
S
V
M
N
MV
S
G
R
V
H
T
Y
P
V
T
E
N
E
N
L
Q
N
L
K
S
W
-------
L
Q
Q
D
T
G
I
P
E
E
E
Q
E
L
L
Q
A
S
G
L
A
L
N
S
A
Q
P
L
T
Q
Y
V
I
D
C
T
V
G
D
L
I
F
L
F
DN
R
K
I
S
L
P
A
H
P
E
S
V
S
I
V
L
Q
D
P
KRPLTYT
H
L
R
R
V
W
G
Q
I
W
Q
T
I
R
A
L
K
E
D
C
A
R
L
L
Q
G
Q
R
T
S
M
V
N
L
L
R
Y
N
T
E
L
S
K
K
K
N
S
M
T
S
E
C
E
Q
L
K
A
K
L
D
F
F
R
S
S
I
Q
I
D
L
E
K
Y
S
E
Q
M
E
F
G
I
T
S
E
K
L
L
S
A
W
R
E
M
E
Q
A
V
E
L
C
G
R
E
R
E
V
Q
A
L
V
D
K
M
M
A
L
Q
T
D
S
V
D
L
Q
R
N
P
T
L
D
D
L
E
E
Q
A
R
D
L
Y
R
R
L
R
E
R
P
R
D
Q
R
T
P
G
D
S
N
D
M
V
R
L
L
I
L
A
I
Q
S
F
E
K
R
V
I
L
I
Y
D
Q
L
S
K
T
V
V
C
K
R
K
A
L
E
L
S
P
K
V
K
E
V
M
N
L
M
R
E
D
E
K
I
V
V
R
R
Q
E
K
R
Q
Q
E
L
W
N
L
L
K
I
A
C
S
K
V
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
64.49
24%
-82
- C2 -
-
2ZOQ
1
MK03_HUMAN
A:
[122-338]
----------------------------------------------------------------------------------------------------
Y
I
V
Q
D
L
M
E
-
T
-
D
L
Y
K
L
L
K
----
S
Q
Q
L
S
N
D
H
I
C
Y
F
L
-
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
I
N
------------------------------
T
T
C
D
L
K
I
C
---------------------
D
F
G
L
A
R
I
A
D
P
E
H
D
H
T
G
F
L
T
--------
E
Y
V
A
------
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
--
T
K
----
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
-
N
R
P
I
F
-
P
G
K
H
---
Y
L
-----------
D
Q
L
N
H
I
L
--------
G
I
-
L
G
S
P
SQEDLNCII
N
M
K
A
R
N
Y
L
-
Q
S
----------------
L
-
P
S
K
-----------------------------------------
T
K
V
A
W
-
A
--
K
-----
L
F
-------
P
K
------
S
-
D
S
K
A
L
D
L
L
D
R
M
L
T
F
N
P
N
K
--
R
I
T
V
------
E
-
E
A
L
A
H
P
Y
-------
L
E
Q
Y
Y
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
64.32
26%
-62
- C2 -
-
4IC7
1
MK07_HUMAN
A:
[133-354]
--------------------------------------------------------------------------------------------
K
-----
S
V
Y
V
V
L
D
L
M
E
-
S
-
D
L
H
Q
I
I
H
S
S
--
Q
P
L
T
L
E
H
--
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
E
N
C
E
--------
L
K
I
G
D
F
G
M
A
R
-------------
G
L
C
T
S
-----------------------------
P
A
E
H
Q
Y
F
M
T
--------
E
Y
V
A
------
T
R
W
Y
R
A
P
E
L
M
L
S
------
L
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
-
R
R
Q
L
F
-
P
G
K
N
Y
V
H
Q
L
-----------
Q
L
I
M
M
V
L
GTPS
P
A
V
I
Q
A
-
V
G
A
E
RVRAY-----------
I
-
Q
S
----------------
L
-
P
-------------------------------------------
P
R
--
Q
-
P
--
V
-----
P
W
-------
E
T
V
--
Y
PG
A
-
D
R
Q
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
--
R
I
S
A
------
A
-
A
A
L
R
H
P
F
-------
L
A
K
Y
H
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
63.62
26%
-6
- C2 -
-
4AZF
2
DYRK2_HUMAN
A:
[142-413]
-------------------------------------------------
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
N
V
I
---
H
M
L
E
N
F
T
F
R
----------
N
-----
H
I
C
M
T
F
E
L
L
S
-
M
-
N
L
Y
E
L
I
K
K
N
--
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
H
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
K
Q
Q
G
R
---------------------------------------------------------
S
G
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
R
------------
V
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
R
-------
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
-
G
Y
P
L
L
-
P
G
E
D
---
E
G
-----------
D
Q
L
A
C
M
I
--------
E
L
-
L
G
M
P
----------------
S
-
Q
K
----------------
L
L
D
A
S
KRAKNFVSSKGYP
R
Y
C
T
V
T
TLS
D
V
V
L
N
G
G
RSR
R
G
K
L
R
G
PPE
S
R
--
E
-
W
--
G
-----
N
A
-------
L
K
G
--
C
--
D
-
D
P
L
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
--
R
M
T
P
------
G
-
Q
A
L
R
H
P
W
-------
L
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
63.57
28%
-22
- C2 -
-
1J1B
1
GSK3B_HUMAN
B:
[96-347]
-------------------------------------------------
R
E
L
Q
I
M
R
K
L
------
D
H
C
N
I
V
---
R
L
R
Y
F
F
Y
S
S
GEKKD
E
----
V
-----
Y
L
N
L
V
L
D
Y
V
P
-
E
-
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
----------------------------------------------------------
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
--------
E
P
--
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
------
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
-
G
Q
P
I
F
-
P
G
D
S
---
G
V
-----------
D
Q
L
V
E
I
I
--------
K
V
-
L
G
T
P
----------------
T
-
R
E
Q
I
R
E
M
NPNYTEFK---
F
-
P
Q
I
-----------------------------------------
K
A
--
H
P
W
--
T
-----
K
V
-------
F
R
P
--
R
--
T
-
P
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
--
R
L
T
P
------
L
-
E
A
C
A
H
S
F
-------
F
D
E
L
R
D
-------
P
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
63.03
26%
0
- C- -
-
2VD5
-
DMPK_HUMAN
A:
[111-351]
--------------------------------------------------
E
R
D
V
L
V
N
G
------
D
R
R
W
I
T
---
Q
L
H
F
A
F
Q
D
E
----------
N
-----
Y
L
Y
L
V
M
E
Y
Y
V
G
G
-
D
L
L
T
L
L
S
K
F
--
G
-
E
R
I
P
A
E
M
A
R
F
Y
L
A
E
I
V
M
A
I
D
S
V
H
R
L
G
Y
V
H
R
D
I
K
P
D
N
I
L
L
D
R
C
G
-----------------------------------------------------------
H
I
R
L
A
D
F
G
S
C
L
K
L
R
A
D
--------
G
T
V
R
S
L
V
A
V
G
T
P
D
Y
L
S
P
E
I
L
Q
A
V
G
G
G
PG
T
G
S
Y
G
P
E
C
D
W
W
A
L
G
V
F
A
Y
E
M
F
Y
-
G
Q
T
P
F
-
Y
A
D
S
---
T
A
-----------
E
T
Y
G
K
I
V
--------
H
Y
-
K
E
H
L
-------------------
S
----------------
L
-
P
------------------------------------------------------------------------
G
--
V
-
P
E
E
A
R
D
F
I
Q
R
L
L
C
P
P
E
T
R
LG
R
G
G
A
------
G
-
D
F
R
T
H
P
F
-------
F
F
G
L
D
W
-------
D
G
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
62.64
24%
-40
- C2 -
-
3RP9
-
?
A:
[101-408]
-------------------------------------------------
R
E
I
A
I
L
N
R
L
------
N
H
D
H
V
V
---
K
V
L
D
I
V
I
P
K
-----
D
VEKF
D
-----
E
L
Y
V
V
L
E
I
A
D
-
S
-
D
F
K
K
L
F
R
T
P
--
V
--
Y
L
T
E
L
H
I
K
T
L
L
Y
N
L
L
V
G
V
K
Y
V
H
S
A
G
I
L
H
R
D
L
K
P
A
N
C
L
V
N
Q
D
C
S
-----------------------------------------------------------
V
K
V
C
D
F
G
L
A
R
T
V
D
Y
P
ENGNSQLP---------
V
T
R
W
Y
R
A
P
E
L
I
L
L
Q
E
------
N
Y
T
E
A
I
D
V
W
S
I
G
C
I
F
A
E
L
L
N
-
M
I
K
E
N
-
V
A
Y
H
---
A
D
RGPLFPT
R
G
N
R
D
Q
L
N
V
I
F
--------
N
I
-
L
G
T
P
----------------
S
-
E
E
D
I
E
A
LEK
E
D
A
K
R
Y
I
R
I
F
-
P
K
R
-----------------------------------------
E
G
--
T
-
D
--
L
-----
A
E
-------
R
F
P
--
A
--
S
-
S
A
D
A
I
H
L
L
K
R
M
L
V
F
N
P
N
K
--
R
I
T
I
------
N
-
E
C
L
A
H
P
F
-------
F
K
E
V
R
I
-------
A
E
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
62.57
27%
-63
- C2 -
-
3TXO
1
A:
[72-293]
-------------------------------------------------
T
E
K
R
I
L
S
L
A
R
-----
N
H
P
F
L
T
---
Q
L
F
C
C
F
Q
T
------
P
----
D
-----
R
L
F
F
V
M
E
F
V
N
-
G
G
D
L
M
F
H
I
Q
K
S
----
R
R
F
D
E
A
R
A
R
F
Y
A
A
E
I
I
S
A
L
M
F
L
H
D
K
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
H
E
G
-----------------------------------------------------------
H
C
K
L
A
D
F
G
M
C
K
E
G
I
C
------------------
G
T
P
D
Y
I
A
P
E
I
L
Q
E
M
L
-------
Y
G
P
A
V
D
W
W
A
M
G
V
L
L
Y
E
M
L
C
-
G
H
A
P
F
-
E
A
E
N
---
E
D
-----------
D
L
F
E
A
I
L
--------
N
D
-
E
V
---------------------
V
----------------
Y
-
P
---------------------------------------------------------------------
T
--
W
--
L
-
H
E
D
A
T
G
I
L
K
S
F
M
T
K
N
P
T
M
--
R
L
G
S
LTQGG
E
H
-
A
I
L
R
H
P
F
-------
F
K
E
I
D
W
-------
A
Q
L
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
61.30
23%
-107
- C2 -
-
4YZ9
1
ERN1_HUMAN
B:
[50-279]
-------------------------------------------------
R
E
V
Q
L
L
R
E
S
D
-----
E
H
P
N
V
I
---
R
Y
F
C
T
E
K
D
------
R
----
Q
-----
F
Q
Y
I
A
I
E
L
C
A
-
A
-
T
L
Q
E
Y
V
E
Q
K
--
D
F
A
H
-
L
G
L
E
P
I
T
L
L
Q
Q
T
T
S
G
L
A
H
L
H
S
L
N
I
V
H
R
D
L
K
P
H
N
I
L
I
S
M
P
N
A
------------------------------------------------------
H
G
K
I
K
A
M
I
S
D
F
G
L
C
-------------------------
E
G
W
I
A
P
E
M
L
S
---------
N
P
T
Y
T
V
D
I
F
S
A
G
C
V
F
Y
Y
V
I
S
E
G
S
H
P
F
-
G
K
S
L
---
Q
R
------------
Q
A
N
I
L
L
--------
G
A
-
C
----------------------
S
----------------
L
-
D
----------------------------------------------------
C
-----
L
H
-------
P
E
K
--
H
--
E
-
D
V
I
A
R
E
L
I
E
K
M
I
A
M
D
P
Q
K
--
R
P
S
A
------
K
-
H
V
L
K
H
P
F
-------
F
W
S
L
E
K
-------
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
61.17
27%
-46
- C2 -
-
4WOT
1
ROCK2_HUMAN
B:
[118-344]
-------------------------------------------------
E
E
R
D
I
M
A
F
A
------
N
S
P
W
V
V
---
Q
L
F
Y
A
F
Q
D
D
----------
R
-----
Y
L
Y
M
V
M
E
Y
M
P
-
G
G
D
L
V
N
L
M
S
N
Y
-----
D
V
P
E
K
W
A
K
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
M
G
L
I
H
R
D
V
K
P
D
N
M
L
L
D
K
H
G
-----------------------------------------------------------
H
L
K
L
A
D
F
G
T
C
M
K
M
D
E
T
--------
G
M
V
H
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
G
G
D
---
G
F
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
-
G
D
T
P
F
-
Y
A
D
S
---
L
V
-----------
G
T
Y
S
K
I
M
--------
D
H
-
K
N
S
L
-------------------
C
----------------
F
-
P
-------------------------------------------------------------------
E
D
A
--
E
--
I
-
S
K
H
A
K
N
L
I
C
A
F
L
T
D
R
E
V
R
LG
R
N
G
V
------
E
-
E
I
R
Q
H
P
F
-------
F
K
N
D
Q
W
-------
H
W
D
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
HHSearch
59.70
26%
-18
- C2 -
-
4E7W
-
?
A:
[77-328]
-------------------------------------------------
R
E
L
Q
I
M
R
I
V
------
K
H
P
N
V
V
---
D
L
K
A
F
F
Y
S
N
-----
G
----
D
KKD
E
V
F
L
N
L
V
L
E
Y
V
P
-
E
-
T
V
Y
R
A
S
R
H
Y
A
K
L
K
Q
T
M
P
M
L
L
I
K
L
Y
M
Y
Q
L
L
R
S
L
A
Y
I
H
S
I
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
P
S
----------------------------------------------------------
G
V
L
K
L
I
D
F
G
S
A
K
I
L
I
A
G
--------
E
P
--
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
------
N
Y
T
T
N
I
D
I
W
S
T
G
C
V
M
A
E
L
M
Q
-
G
Q
P
L
F
-
P
G
E
S
---
G
I
-----------
D
Q
L
V
E
I
I
--------
K
V
-
L
G
T
P
----------------
S
-
R
E
Q
I
K
T
MNPNYM
E
H
K
---
F
-
P
Q
I
-----------------------------------------
R
P
--
H
P
F
--
S
-----
K
V
-------
F
R
P
--
R
--
T
-
P
P
D
A
I
D
L
I
S
R
L
L
E
Y
T
P
S
A
--
R
L
T
A
------
I
-
E
A
L
C
H
P
F
-------
F
D
E
L
R
T
-------
G
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
Fugue
59.09
17%
-3
- C2 -
-
2RIO
1
IRE1_YEAST
A:
[8-434]
NFEQSLKN
L
V
V
S
EKIL
G
Y
G
S
SG
T
V
V
F
Q
G
S
FQG
R
P
V
A
V
K
R
M
LIDF
C
D
I
A
L
M
E
I
K
L
L
T
E
S
D
-----
D
H
P
N
V
I
---
R
Y
Y
C
S
E
T
T
D
-----
R
----------
F
L
Y
I
A
L
E
L
C
N
-
L
-
N
L
Q
D
L
V
E
S
K
--
Y
N
-------
P
I
S
L
L
R
Q
I
A
S
G
V
A
H
L
H
S
L
K
I
I
H
R
D
L
K
P
Q
N
I
L
V
S
T
S
S
R
F
T
A
------------
D
Q
Q
T
G
A
E
N
L
R
I
L
I
S
D
F
G
L
C
K
K
L
D
S
T
S
G
W
R
A
P
E
L
L
E
E
S
N
N
---------------------------------------------------
L
Q
T
--
K
R
R
L
T
R
S
I
D
I
F
S
M
G
C
V
F
Y
Y
I
L
S
K
G
K
H
P
F
-
G
D
K
Y
---
S
------------------------------
R
E
S
N
----------------
I
-
I
R
----------------
G
-
I
F
S
-----------------------------------------
L
D
--
E
-
M
--
K
-----
C
L
-------
H
D
R
--
S
--
L
-
I
A
E
A
T
D
L
I
S
Q
M
I
D
H
D
P
L
K
--
R
P
T
A
------
M
-
K
V
L
R
H
P
L
FWP
K
S
K
K
L
E
F
L
L
K
-------
V
S
D
R
L
-----
E
I
E
N
R
D
P
P
S
A
L
L
M
K
F
D
A
G
S
D
F
VIPSGDW
T
V
K
F
D
K
T
F
M
D
R
K
Y
H
S
S
K
L
M
D
L
L
R
A
L
R
N
K
Y
H
H
F
M
D
L
P
E
D
--------
I
A
E
L
M
G
P
V
P
D
G
F
Y
D
Y
F
T
K
R
FPN----
L
L
I
G
V
Y
M
I
V
K
E
N
L
S
D
D
Q
I
L
R
E
F
L
Y
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
59.06
27%
-49
- C2 -
-
3V8S
1
ROCK1_HUMAN
D:
[118-341]
-------------------------------------------------
E
E
R
D
I
M
A
F
A
------
N
S
P
W
V
V
---
Q
L
F
Y
A
F
Q
D
D
----------
R
-----
Y
L
Y
M
V
M
E
Y
M
P
-
G
G
D
L
V
N
L
M
S
N
Y
-----
D
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
-----------------------------------------------------------
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
E
--------
G
M
V
R
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
G
G
D
---
G
Y
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
-
G
D
T
P
F
-
Y
A
D
S
---
L
V
-----------
G
T
Y
S
K
I
M
--------
N
H
-
K
N
S
-------------------
L
T
----------------
F
-
P
-------------------------------------------------------------------
D
D
N
--
D
--
I
-
S
K
E
A
K
N
L
I
C
A
F
L
T
D
R
E
V
R
LG
R
N
G
V
------
E
-
E
I
K
R
H
L
F
-------
F
K
N
D
Q
W
-------
A
W
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------