@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_24_1500: (2018-03-10 )
MVTTIGNGGGVVATCGQCGTAFQKLSARFCSRCGARRDIPAAAAVTAAAAARKPKPKEAVVSMPPLPSAGKESVSRPPADGAKGTLRPFDLEKLSEKRSSGGGSVAPPPLTEVSASALEFRDPSEATSITTPKRRASLATAAGGVLSSAVDASLTLSDQQRRREQRASSNYVKDGSLTGPPLASMADRDQLEHVLTSSSQEDAAMGGAAGNGVDRSHVPIPPPEQRPPSTFPLSVALVRRDGGRAAVTDGADFKGASVKTAPTAWPAEAQASTSNGGDTEEAIASLRPSAEEEAQYTAWVTLSPDDLTPEMLQTSNASELRQWRKGSLIGRGTYGSVYLGLLPDGSFHAVKCVELGNRKAAADHLGALELVSLSREVNMMHRLRHRNLCTFKGVYFDSESACVCMFMEYIGGGSLSALVKKFKPLPSSVVRSWTQQLLSGLHYLHSQHIIHRDIKGDNVLVDTTADPATKSQIKLVDFGAARRLTDAVSQSSTVIGTPYWMAPEVVDASGDGSGYSYKADVWSVGCTVAEMLTGRPPWPCKTSAPAAIMMIASATGMPTEIPEEEATPGCLDFMRQCFIRDPEKRPTVQQLLQHPWIQVKME
Atome Classification :
(25 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320-.......330.......340.-.-......350.......360.......370.......380.-.-.....390......----.----400.......410.-....-..420..----.....--.430.......440.......450.......460.......470-----.........480.......490.......500....--...510.---........520.......530.-......540.......550...-....560........570.......580.......590.......600-----------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
V
T
T
IGNGG
G
V
V
A
TC
G
Q
C
G
T
A
F
Q
K
L
S
A
R
F
C
S
RCGARRDI
P
A
A
A
A
V
T
A
A
A
AARKPKP
K
E
AVVSMPPLPSAGKESVSRPPADGAKGTLRP
F
D
L
E
K
L
S
E
K
RSSGGGSVAPPP
L
T
EVSA
S
A
LEFRDPSEATSITT
P
K
R
R
A
S
L
A
T
AA
G
G
V
L
S
S
AVD
A
S
L
T
L
S
D
Q
Q
R
R
R
E
Q
RASSNYVKDGSLTGPP
L
A
S
MA
D
R
D
Q
L
E
H
V
L
TSSSQEDAAMGGAAGNGVDRSHVPIPPPEQRPPSTF
P
L
S
V
A
L
V
RRDGG
R
A
AVTDGADFKGASVKTAPTAWPAEAQASTSNGG
D
T
E
E
A
I
A
SLRPSAEEEA
Q
Y
T
A
W
V
T
LSPDDL
T
P
E
M
L
QTS
N
A
S
E
L
R
Q
-
W
RKGSLIGRGTYG
S
V
Y
L
G
L-L-P-DGS
F
H
A
V
K
C
VELGNR
K
A
A
A
D
H
L
G
A
L
E
L
V
S
L
S
R
E
V
N
M
M
H
R
L
-
R
-HRNL
C
T
F
K
G
V
Y
FDS----E----
S
A
C
V
C
M
F
M
E
Y
IGGG-
S
L
S
A
-
L
V
K
-KFK----PL
P
S
S
--
V
V
R
S
W
T
Q
Q
L
L
S
G
L
H
Y
L
H
S
Q
H
I
I
H
RDIKGD
N
V
L
V
DTTADPATK-------
S
Q
I
K
L
V
DFG
A
A
R
R
L
T
D
A
VSQSS
T
V
IGTPYWMAP
E
V
V--DASG--D---GSG
Y
S
Y
K
A
D
V
W
S
V
G
C
T
V
A
E
M
LT-GRPPWPCKTSA
P
A
A
I
M
M
I
ASAT-GMPTEI-PEEEAT
P
G
C
L
D
F
M
R
Q
C
FIRDPEKR
P
T
V
Q
Q
L
L
QHP
W
I
Q
V
KME-----------------------------------------------------------------------------------------------------------------------------
49
Fugue
66.44
25%
-19
- C1 -
-
2RIO
1
IRE1_YEAST
A:
[8-434]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
F
E
Q
S
L
K
N
L
V
V
S
E
K
I
L
G
Y
G
S
S
G
T
V
V
F
Q
G
-
S
-
F
-
Q
G
R
P
V
A
V
K
R
M
L
I
D
F
C
D
I
A
L
M
E
I
K
L
L
T
E
S
D
------------
D
-
H
P
N
V
I
R
Y
Y
C
S
E
T
T
D
----
R
----
F
L
Y
I
A
L
---
E
L
C
N
L
-
N
L
Q
D
-
L
V
E
-
S
K
Y
----
N
-------
P
I
S
L
L
R
Q
I
A
S
G
V
A
H
L
H
S
L
K
I
I
H
R
D
L
K
P
Q
N
I
L
V
S
T
S
S
R
F
T
A
D
QQTGAEN
L
R
I
L
I
S
D
F
G
L
C
K
K
L
D
----------
S
T
S
G
W
R
A
P
E
L
L
--
E
E
S
N
--
N
LQT
K
R
R
L
T
R
S
I
D
I
F
S
M
G
C
V
F
Y
Y
I
L
S
K
G
K
H
P
F
G
D
K
Y
S
R
E
S
N
I
I
R
G
I
F
S
L
-
D
E
M
K
C
L
-
H
D
R
S
L
I
A
E
A
T
D
L
I
S
Q
M
I
D
H
D
P
L
K
R
P
T
A
M
K
V
L
R
H
P
L
F
W
P
K
S
K
K
L
E
F
L
L
K
V
S
D
R
L
E
I
ENRDPPS
A
L
L
M
K
F
D
A
G
S
DFVIPSGDWTVKFDKTFMDRKYHSSK
L
M
D
L
L
R
A
L
R
N
K
Y
H
H
F
MDLP
E
D
I
A
E
L
M
GPVP
D
G
F
Y
D
Y
F
T
K
R
FPN
L
L
I
G
V
Y
M
I
V
K
E
NLSDD
Q
I
L
R
E
F
L
YS
47
Fugue
66.00
21%
-21
- C1 -
-
1KOB
1
?
A:
[23-374]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
N
D
Y
D
K
F
Y
E
D
I
W
K
K
Y
V
P
Q
P
V
E
V
K
Q
G
S
V
Y
D
Y
-
Y
D
I
L
E
E
L
G
S
G
A
F
G
V
V
H
R
C
V
-
E
K
A
-
T
G
R
V
F
V
A
K
F
I
N
T
P
Y
---------
P
L
D
K
Y
T
V
K
N
E
I
S
I
M
N
Q
L
-
H
-
H
P
K
L
I
N
L
H
D
A
F
E
D
K
----
Y
------
E
M
V
L
I
L
E
F
L
S
G
G
-
E
L
F
D
R
I
A
A
-
E
D
Y
----
K
M
S
E
A
--
E
V
I
N
Y
M
R
Q
A
C
E
G
L
K
H
M
H
E
H
S
I
V
H
L
D
I
K
P
E
N
I
M
C
E
T
K
----
K
A
-------
S
S
V
K
I
I
D
F
G
L
A
T
K
L
N
P
D
-
E
I
V
K
V
T
T
A
T
A
E
F
A
A
P
E
I
V
--
D
---------
R
E
P
V
G
F
Y
T
D
M
W
A
I
G
V
L
G
Y
V
L
L
S
-
G
L
S
P
F
A
G
E
D
D
L
E
T
L
Q
N
V
K
R
C
D
W
-
E
F
D
E
D
--
A
F
S
S
V
S
P
E
A
K
D
F
I
K
N
L
L
Q
K
E
P
R
K
R
L
T
V
H
D
A
L
E
H
P
W
L
K
G
D
H
S
NLTSRIPSSRY
N
K
I
R
Q
K
I
K
E
K
Y
ADWPAPQPAIGRIANFSSLRKHRPQEYQ
I
Y
D
S
Y
F
DRKEA----------------------------------------------------------------
19
PsiBlast_PDB
65.37
33%
-23
- C1 -
-
4U45
1
M4K4_HUMAN
A:
[30-291]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
-
K
-
T
G
Q
L
A
A
I
K
V
M
D
V
T
E
D
E
E
E
E
----------
I
K
L
E
I
N
M
L
K
K
Y
S
H
-
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
SPP------
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
-
S
I
T
D
-
L
V
K
-
N
T
K
GN--
T
L
K
E
D
--
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
N
A
-------------
E
V
K
L
V
D
F
G
V
S
A
---------
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
AC
D
E
N
P
--
D
---
A
T
-
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
-
G
A
P
P
L
-
C
D
M
H
P
M
R
A
L
F
L
I
P
R
N
P
---
P
P
R
L
-
K
S
K
K
W
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
---------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
63.77
33%
-24
- C1 -
-
4U44
2
M4K4_HUMAN
A:
[30-291]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
-
K
-
T
G
Q
L
A
A
I
K
V
M
D
V
T
E
D
E
E
E
E
----------
I
K
L
E
I
N
M
L
K
K
Y
S
H
-
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
S---
H
----
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
-
S
I
T
D
-
L
V
K
-
N
T
K
GN--
T
L
K
E
D
--
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
N
A
-------------
E
V
K
L
V
D
F
G
V
S
A
----------
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
AC
D
E
N
P
--
D
---
A
T
-
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
-
G
A
P
P
L
-
C
D
M
H
P
M
R
A
L
F
L
I
P
R
N
P
---
P
P
R
L
-
K
S
K
K
W
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
---------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
62.17
33%
-25
- C1 -
-
4OBP
2
M4K4_HUMAN
A:
[30-291]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
-
K
-
T
G
Q
L
A
A
I
K
V
M
D
V
T
E
D
E
E
E
E
----------
I
K
L
E
I
N
M
L
K
K
Y
S
H
-
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
S--------
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
-
S
I
T
D
-
L
V
K
-
N
T
K
GN--
T
L
K
E
D
--
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
N
A
-------------
E
V
K
L
V
D
F
G
V
S
A
---------
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
AC
D
E
N
P
--
D
---
A
T
-
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
-
G
A
P
P
L
-
C
D
M
H
P
M
R
A
L
F
L
I
P
R
N
P
---
P
P
R
L
-
K
S
K
K
W
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
---------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
61.59
32%
-44
- C1 -
-
5J5T
1
M4K3_HUMAN
A:
[4-267]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
-
F
E
L
I
Q
R
I
G
S
G
T
Y
G
D
V
Y
K
A
R
-
N
-
V
N
T
G
E
L
A
A
I
K
V
I
K
L
E
P
G
---------
E
D
F
A
V
V
Q
Q
E
I
I
M
M
K
D
C
-
K
-
H
P
N
I
V
A
Y
F
G
S
Y
L
R
R
----
D
------
K
L
W
I
C
M
E
F
C
G
G
G
-
S
L
Q
D
-
I
Y
H
-
V
T
G
----
P
L
S
E
L
--
Q
I
A
Y
V
S
R
E
T
L
Q
G
L
Y
Y
L
H
S
K
G
K
M
H
R
D
I
K
G
A
N
I
L
L
T
D
N
G
-------------
H
V
K
L
A
D
F
G
V
S
A
Q
I
T
A
T
I
A
---
A
F
I
G
T
P
Y
W
M
A
P
E
V
A
--
A
V
E
---
R
---
K
G
G
Y
N
Q
L
C
D
L
W
A
V
G
I
T
A
I
E
L
A
E
-
L
Q
P
P
M
F
D
L
H
P
M
R
A
L
-
F
L
M
T
K
S
N
-
F
Q
P
P
K
L
K
D
K
M
K
W
S
N
S
F
H
H
F
V
K
M
A
L
T
K
N
P
K
K
R
P
T
A
E
K
L
L
Q
H
P
F
V
T
Q
--------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
59.25
27%
-39
- C1 -
-
2X0G
-
DAPK1_HUMAN
A:
[10-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
Y
-
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
-
E
-
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
---
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
-
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
----
T
------
D
V
I
L
I
L
E
L
V
A
G
G
-
E
L
F
D
-
F
L
A
-
E
K
E
----
S
L
T
E
E
--
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
--
P
K
-------
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
-
N
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
--
N
Y
---------
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
-
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
-
E
F
E
-
D
E
-
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
--------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
59.10
27%
-38
- C1 -
-
3C0I
1
CSKP_HUMAN
A:
[24-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
-
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
-
N
-
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
----
S
P
G
L
S
T
E
D
L
K
R
E
A
S
I
C
H
M
L
-
K
-
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
----
G
------
M
L
Y
M
V
F
E
F
M
D
G
A
-
D
L
C
F
-
E
I
V
-
K
R
A
D
A
G
F
V
Y
S
E
A
--
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
E
---
N
S
-------
A
P
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
S
G
L
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
--
K
R
---------
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
-
G
C
L
P
F
Y
G
T
K
E
R
--
L
F
E
G
I
I
K
G
K
-
Y
K
M
N
P
R
-
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
-------------------------------------------------------------------------------------------------------------------------------
45
Fugue
58.27
25%
-21
- C1 -
-
1TKI
-
TITIN_HUMAN
A:
[18-338]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
L
Y
E
K
-
Y
M
I
A
E
D
L
G
R
G
E
F
G
I
V
H
R
C
V
E
T
-
S
-
S
K
K
T
Y
M
A
K
F
V
K
V
K
G
----------
T
D
Q
V
L
V
K
K
E
I
S
I
L
N
I
A
-
R
-
H
R
N
I
L
H
L
H
E
S
F
E
S
M
----
E
------
E
L
V
M
I
F
E
F
I
S
G
L
D
I
F
E
R
-
I
N
T
-
S
A
F
----
E
L
N
E
R
--
E
I
V
S
Y
V
H
Q
V
C
E
A
L
Q
F
L
H
S
H
N
I
G
H
F
D
I
R
P
E
N
I
I
Y
Q
T
R
R
S
S
-----------
T
I
K
I
I
E
F
G
Q
A
R
Q
L
K
P
G
-
D
N
F
R
L
L
F
T
A
P
E
Y
Y
A
P
E
V
H
--
Q
---------
H
D
V
V
S
T
A
T
D
M
W
S
L
G
T
L
V
Y
V
L
L
S
-
G
I
N
P
F
L
-
A
E
T
N
Q
Q
I
I
E
N
I
M
N
A
E
-
Y
T
F
D
E
E
-
A
F
K
E
I
S
I
E
A
M
D
F
V
D
R
L
L
V
K
E
R
K
S
R
M
T
A
S
E
A
L
Q
H
P
W
L
K
Q
K
I
E
RVSTKVIRT
L
K
H
R
R
Y
Y
H
T
L
IKKDLNMVVSAARISCGGAIRSQKG
V
S
V
A
K
V
K
V
A
SI----------------------------------------------------------------------
17
PsiBlast_PDB
57.63
33%
-4
- C1 -
-
4U43
1
M4K4_HUMAN
A:
[30-291]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
-
K
-
T
G
Q
L
A
A
I
K
V
M
D
V
T
E
D
E
E
E
E
----------
I
K
L
E
I
N
M
L
K
K
Y
S
H
-
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
SPPG
H
----
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
-
S
I
T
D
-
L
V
K
-
N
T
K
GN--
T
L
K
E
D
--
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
N
A
-------------
E
V
K
L
V
D
F
G
V
-----------
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
AC
D
E
N
P
--
D
---
A
T
-
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
-
G
A
P
P
L
-
C
D
M
H
P
M
R
A
L
F
L
I
P
R
N
P
---
P
P
R
L
-
K
S
K
K
W
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
---------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
57.55
30%
-39
- C1 -
-
4XBR
1
INKA1_HUMAN (first)
A:
[94-350]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Y
-
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
-
V
-
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
Q
---------
Q
R
R
E
L
L
F
N
E
V
V
I
M
R
D
Y
-
Q
-
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
----
D
------
E
L
W
V
V
M
E
F
L
E
G
G
-
A
L
T
D
-
I
V
T
-
H
T
-----
R
M
N
E
E
--
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
-------------
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
--
S
R
---------
L
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
-
G
E
P
P
Y
F
N
E
P
P
L
K
A
-
M
K
M
I
R
D
N
---
L
P
P
R
L
K
N
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
A
K
A
-------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
57.07
27%
-31
- C1 -
-
1TKI
-
TITIN_HUMAN
A:
[21-282]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
K
-
Y
M
I
A
E
D
L
G
R
G
E
F
G
I
V
H
R
C
V
-
E
-
T
S
S
K
K
T
Y
M
A
K
F
V
K
V
K
G
T
----------
D
Q
V
L
V
K
K
E
I
S
I
L
N
I
A
-
R
-
H
R
N
I
L
H
L
H
E
S
F
E
S
M
----
E
------
E
L
V
M
I
F
E
F
I
S
G
L
-
D
I
F
E
-
R
I
N
-
T
S
A
F
---
E
L
N
E
R
--
E
I
V
S
Y
V
H
Q
V
C
E
A
L
Q
F
L
H
S
H
N
I
G
H
F
D
I
R
P
E
N
I
I
Y
Q
T
R
R
----
S
-------
S
T
I
K
I
I
E
F
G
Q
A
R
Q
L
K
P
G
-
D
N
F
R
L
L
F
T
A
P
E
Y
Y
A
P
E
V
H
--
Q
H
---------
D
V
V
S
T
A
T
D
M
W
S
L
G
T
L
V
Y
V
L
L
S
-
G
I
N
P
F
L
A
E
T
N
Q
Q
-
I
I
E
N
I
M
N
A
E
-
Y
T
F
D
E
E
-
A
F
K
E
I
S
I
E
A
M
D
F
V
D
R
L
L
V
K
E
R
K
S
R
M
T
A
S
E
A
L
Q
H
P
W
L
K
Q
K
I
------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
56.79
27%
-30
- C1 -
-
4B4L
3
DAPK1_HUMAN
A:
[12-279]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
Y
-
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
-
E
-
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
---
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
-
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
----
T
------
D
V
I
L
I
L
E
L
V
A
G
G
-
E
L
F
D
-
F
L
A
-
E
K
E
----
S
L
T
E
E
--
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
--
P
K
-------
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
-
N
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
--
N
Y
---------
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
-
G
A
S
P
F
L
G
D
T
K
Q
E
T
-
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
--
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
--------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
55.26
33%
-1
- C1 -
-
4ZK5
2
M4K4_HUMAN
A:
[30-291]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
-
K
-
T
G
Q
L
A
A
I
K
V
M
D
V
T
E
D
E
E
E
E
----------
I
K
L
E
I
N
M
L
K
K
Y
S
H
-
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
S
P
PG
H
----
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
-
S
I
T
D
-
L
V
K
-
N
T
K
GN--
T
L
K
E
D
--
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
N
A
-------------
E
V
K
L
V
D
F
G
V
S
A
---------
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
AC
D
E
N
P
--
D
---
A
T
-
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
-
G
A
P
P
L
-
C
D
M
H
P
M
R
A
L
F
L
I
P
R
N
P
---
P
P
R
L
-
K
S
K
K
W
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
---------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
54.88
25%
-10
- C1 -
-
2PHK
2
PHKG1_RABIT
A:
[4-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
-
Y
E
P
K
E
I
L
G
R
G
V
S
S
V
V
R
R
C
I
-
H
-
K
P
T
C
K
E
Y
A
V
K
I
I
D
V
T
G
G
G
S
F
S
A
E
E
V
Q
E
L
R
E
A
T
L
K
E
V
D
I
L
R
K
V
-
S
G
H
P
N
I
I
Q
L
K
D
T
Y
E
T
N
----
T
------
F
F
F
L
V
F
D
L
M
K
K
G
-
E
L
F
D
-
Y
L
T
-
E
K
V
----
T
L
S
E
K
--
E
T
R
K
I
M
R
A
L
L
E
V
I
C
A
L
H
K
L
N
I
V
H
R
D
L
K
P
E
N
I
L
L
D
D
D
M
-------------
N
I
K
L
T
D
F
G
F
S
C
Q
L
D
P
G
E
-
K
L
R
E
V
C
G
T
P
S
Y
L
A
P
E
I
I
--
E
C
S
M
N
D
N
---
H
P
G
Y
G
K
E
V
D
M
W
S
T
G
V
I
M
Y
T
L
L
A
-
G
S
P
P
F
W
H
R
K
Q
M
L
-
M
L
R
M
I
M
S
G
N
-
Y
Q
F
G
S
P
-
E
W
D
D
Y
S
D
T
V
K
D
L
V
S
R
F
L
V
V
Q
P
Q
K
R
Y
T
A
E
E
A
L
A
H
P
F
F
Q
Q
--------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
53.59
32%
10
- C1 -
-
5AX9
1
TNIK_HUMAN
A:
[23-284]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
-
K
-
T
G
Q
L
A
A
I
K
V
M
D
V
T
G
D
----------
E
E
E
E
I
K
Q
E
I
N
M
L
K
K
Y
S
H
-
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
----
N
PPG
M
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
-
S
V
T
D
-
L
I
K
-
N
T
K
GN--
T
L
K
E
E
--
W
I
A
Y
I
C
R
E
I
L
R
G
L
S
H
L
H
Q
H
K
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
N
A
-------------
E
V
K
L
V
D
F
G
V
S
--------------
G
T
P
Y
W
M
A
P
E
V
I
AC
D
E
N
P
--
D
---
A
T
-
Y
D
F
K
S
D
L
W
S
L
G
I
T
A
I
E
M
A
E
-
G
A
P
P
L
-
C
D
M
H
P
M
R
A
L
F
L
I
P
R
N
P
-
A
--
P
R
L
-
K
S
K
K
W
S
K
K
F
Q
S
F
I
E
S
C
L
V
K
N
H
S
Q
R
P
A
T
E
Q
L
M
K
H
P
F
I
R
---------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
53.04
26%
-54
- C1 -
-
3I6U
-
CHK2_HUMAN
A:
[218-489]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
-
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
-
E
-
R
K
T
C
K
K
V
A
I
R
I
I
S
K
R
K
F
A
I
G
---------
L
N
V
E
T
E
I
E
I
L
K
K
L
-
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
-----------
D
Y
Y
I
V
L
E
L
M
E
G
G
-
E
L
F
D
-
K
V
V
-
G
N
K
----
R
L
K
E
A
--
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
---
E
D
-------
C
L
I
K
I
T
D
F
G
H
S
K
I
L
G
------------
P
T
Y
L
A
P
E
V
L
--
V
----------
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
-
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
-
Y
N
F
I
P
E
-
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
-------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
53.01
26%
-11
- C1 -
-
2Y7J
1
PHKG2_HUMAN
D:
[93-365]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Q
K
-
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
-
H
-
R
A
T
G
H
E
F
A
V
K
I
M
E
V
---
R
L
S
P
E
Q
-
L
E
E
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
A
G
-
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
----
S
------
F
M
F
L
V
F
D
L
M
R
K
G
-
E
L
F
D
-
Y
L
T
-
E
K
V
----
A
L
S
E
K
--
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
D
D
N
M
-------------
Q
I
R
L
S
D
F
G
F
S
C
H
L
E
P
G
E
-
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
--
K
C
S
M
DE
T
---
H
P
G
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
-
G
S
P
P
F
W
H
R
R
Q
I
L
-
M
L
R
M
I
M
E
G
Q
-
Y
Q
F
S
S
P
-
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
A
E
Q
A
L
Q
H
P
F
F
E
R
--------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
52.96
27%
-34
* C1 *
-
3C0G
1
CSKP_HUMAN
B:
[24-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
-
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
-
N
-
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
----
S
P
G
L
S
T
E
D
L
K
R
E
A
S
I
C
H
M
L
-
K
-
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
----
G
------
M
L
Y
M
V
F
E
F
M
D
G
A
-
D
L
C
F
-
E
I
V
-
K
R
A
D
A
G
F
V
Y
S
E
A
--
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
E
---
N
S
-------
A
P
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
S
G
L
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
--
K
R
---------
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
-
G
C
L
P
F
Y
G
T
K
E
R
--
L
F
E
G
I
I
K
G
K
-
Y
K
M
N
P
R
-
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
-------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
52.73
24%
-53
- C1 -
-
2BDW
-
KCC2D_CAEEL
A:
[11-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
N
-
Y
D
V
K
E
E
L
G
K
G
A
F
S
V
V
R
R
C
V
-
H
-
K
T
T
G
L
E
F
A
A
K
I
I
N
T
K
K
L
S
-------
A
R
D
F
Q
K
L
E
R
E
A
R
I
C
R
K
L
-
Q
-
H
P
N
I
V
R
L
H
D
S
I
Q
E
E
----
S
------
F
H
Y
L
V
F
D
L
V
T
G
G
-
E
L
F
E
-
D
I
V
-
A
R
E
----
F
Y
S
E
A
--
D
A
S
H
C
I
Q
Q
I
L
E
S
I
A
Y
C
H
S
N
G
I
V
H
R
N
L
K
P
E
N
L
L
L
A
S
K
A
---
K
G
-------
A
A
V
K
L
A
D
F
G
L
A
I
E
V
N
D
S
E
-
A
W
H
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
--
K
K
---------
D
P
Y
S
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
-
G
Y
P
P
F
W
D
E
D
Q
H
R
-
L
Y
A
Q
I
K
A
G
A
-
Y
D
Y
P
S
P
-
E
W
D
T
V
T
P
E
A
K
S
L
I
D
S
M
L
T
V
N
P
K
K
R
I
T
A
D
Q
A
L
K
V
P
W
I
C
N
R
-------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
48.71
36%
11
- C1 -
-
2CLQ
1
M3K5_HUMAN
A:
[29-284]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
-
S
-
N
Q
V
R
I
A
I
K
--
E
I
P
E
R
D
S
---
Q
-------
P
L
H
E
E
I
A
L
H
K
H
L
-
K
-
H
K
N
I
V
Q
Y
L
G
S
F
--
S
----
E
----
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
-
S
L
S
A
-
L
L
R
S
K
W
G
----
P
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
------------
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
G
-----
E
T
F
T
G
T
L
Q
Y
M
A
P
E
I
I
--
D
K
G
-------
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
-
G
K
P
P
F
-
Y
E
L
G
E
P
Q
A
A
M
F
K
V
G
M
F
-
K
V
H
P
E
I
-
P
E
S
M
S
A
E
A
K
A
-
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
--------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
47.36
35%
9
- C1 -
-
4BIC
2
M3K5_HUMAN
A:
[26-281]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
-
S
-
N
Q
V
R
I
A
I
K
--
E
I
P
E
-----
S
Q
-------
P
L
H
E
E
I
A
L
H
K
H
L
-
K
-
H
K
N
I
V
Q
Y
L
G
S
F
--
S
----
E
----
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
-
S
L
S
A
-
L
L
R
S
K
W
G
----
P
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
------------
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
G
------
E
F
T
G
T
L
Q
Y
M
A
P
E
I
I
--
D
K
G
-------
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
-
G
K
P
P
F
-
Y
E
L
G
E
P
Q
A
A
M
F
K
V
G
M
F
-
K
V
H
P
E
I
-
P
E
S
M
S
A
E
A
K
A
-
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
--------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
47.12
35%
4
- C1 -
-
4BIE
2
M3K5_HUMAN
A:
[26-281]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
-
S
-
N
Q
V
R
I
A
I
K
--
E
I
P
E
---------------
L
H
E
E
I
A
L
H
K
H
L
-
K
-
H
K
N
I
V
Q
Y
L
G
S
F
--
S
----
E
----
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
-
S
L
S
A
-
L
L
R
S
K
W
G
----
P
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
------------
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
G
------
E
F
T
G
T
L
Q
Y
M
A
P
E
I
I
--
D
K
G
-------
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
-
G
K
P
P
F
-
Y
E
L
G
E
P
Q
A
A
M
F
K
V
G
M
F
-
K
V
H
P
E
I
-
P
E
S
M
S
A
E
A
K
A
-
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
--------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
42.74
36%
5
- C1 -
-
5V24
1
M3K5_HUMAN
A:
[16-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
-
S
-
N
Q
V
R
I
A
I
K
--
E
I
P
E
R
D
S
-----------
P
L
H
E
E
I
A
L
H
K
H
L
-
K
-
H
K
N
I
V
Q
Y
L
G
S
F
--
S
----
E
----
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
-
S
L
S
A
-
L
L
R
S
K
W
G
----
P
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
------------
G
V
L
K
I
S
D
F
G
T
S
K
R
L
---------
F
T
G
T
L
Q
Y
M
A
P
E
I
I
--
D
------------
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
-
G
K
P
P
F
-
Y
E
--
E
P
Q
A
A
M
F
K
V
G
M
F
-
K
V
H
P
E
I
-
P
E
S
M
S
A
E
A
K
A
-
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
---------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
41.73
36%
-5
- C1 -
-
5UOR
1
M3K5_HUMAN
A:
[16-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
-
S
-
N
Q
V
R
I
A
I
K
--
E
I
P
E
R
D
S
R
Y
S
Q
-------
P
L
H
E
E
I
A
L
H
K
H
L
-
K
-
H
K
N
I
V
Q
Y
L
G
S
F
--
S
----
E
----
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
-
S
L
S
A
-
L
L
R
S
K
W
G
----
P
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
------------
G
V
L
K
I
S
D
F
G
T
S
K
R
L
---------
F
T
G
T
L
Q
Y
M
A
P
E
I
I
--
D
------------
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
-
G
K
P
P
F
-
Y
E
------
A
M
F
K
V
G
M
F
-
K
V
H
P
E
I
-
P
E
S
M
S
A
E
A
K
A
-
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
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