@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_24_1800: (2018-03-10 )
MGCSTSTHASPEADEDAPLKRSVYSASRTSDQVVSGRQNSNKDQTNDACTAVSENPSRTRSSSDTEGRAHGRGIGAIHYPNQLGKDECDGGEDEVVVIPPSADKSTRTRFTFPQRTLLNVGSHTQAGDSGERKRNSITASPSSFTAMQRRLSDGSHGHSSFTTMSPAPPDAKETPLQLTQTRALPTAATIPTACLSISPPQRLSIPANSFAGSSASASGAVALPSQEQHQIETPHVNDGGFSIEWDEEDNTPRGRGIPDSTTTESGPCSVTRGMMAPSGSFGIGVGGGWRSKSPKWIDLSRKRSQSTVSLLSLADTPNNPHVLSSGSDFGRDILGGSHVFGGLATGGGSSRPQSGYAMGRDMCVERFDQQRHSNGLAVFCNQPRECALCRNATAAFACEVCDDFFLCENCRFDLEAVCAVHDPTHAILYMQDNHYNSSRTFGGDSIFSLSGDGGVSSLFYNPCFKCKRVIDDVEPVYRCDQCDYIVCQECFIQHEEPGNAMERASSLSAAMAATREEQASCKPLPIESAALVLASGPMPPHEHELKRFQRKSRSNSVHEGAVVTKTRNSGGNKVINDYVVVRQIGHGSYAKVKLVQHVHTQELFALKILRRQKKAAMSGITLGRSRVKSAMAGISEDDLLREIAVMKFIGHPNVVKLKEVIEDVDSQKVYIIMEYCEKGPVHVLGDPALPLEQVRQYGADILRGLLHLHSEFLYHRDIKPANCLVNRDSVVKIADFGTCNSQIRTKLAEGTPAFSCPEQVRGEEVSGEVVDSWAFALTVYEMACGTLPVSTTSFVQHRSLLMSKSPVPIPKIGDEPLCDLLAQMLEKDLSKRLLLPAATRHPFFAECHVDVHGAVPGTAPRSIFAVLATSGGSAAAQPQQQQLPSLAELYDKALESVHRGKNLKDCFHGVRALRRVRRKEVETARHSGTGDQVGGGSAGAEKSSAYVMNSRDVYGGSDGSGSDGEDEEGAGRLWVGGRAGHKEEAAAAAAVEEAVEHHLFTQEPKLELAQVTLTAPATLEKLNRLHQVTAEMRLSHNALVRLAPLRLSTFSMLMDIAVTFNRLEAIPQEVLAAPRLVRLDLSHNRIDSIPGSLVTKALFLERLSLHHNLITSVGTTTITVVEPSPVTFRVPTSATATCMGSNMVAVPDASVVSSSITQTSLPGRGGSSRSKVVSVLAAPCLRHVRLSGNPLERLPDALETTHKLQLVLDAIPALMEQWDTHMQADSKPTTSTAAAATGGQSRLPAVIVWDDSFPVRIPSVEPAVWLAVNNVAIYRVQTLRLCQTRRVVLCQCADPRFPNGLFLSEELEVYFAALSKALQDCREQRQQLAVEAPFSLSAPAEAIPSEALPPIVGKAARNYVESYFFVTDDENEEEGGYHSLVSYLYDSLSANIPVLVVVVSSGTSCAVRTNIVAAISTCLTRLRGGDPEQLDAEQAELIVSTMRSLYA
Atome Classification :
(22 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570--.......580.......590.......600.......610.......620.......630....-----...640-.........-650.......660.----.----.....670.......680-.....-----.------.----.-690-........700.......710........720...---..-.---.730.......--740--.-..----.-----.....---750.......760-----..---.....770.......780.......790.......-800-....----------------------------.--.--..810....--.....-820.......830-..-----.-----.....840....---...850.......860.......870.......880.......890......-------.900.......910.......920.......930.......940.......950.......960.......970---.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320......1330......1340......1350......1360......1370......1380......1390......1400......1410......1420......1430......1440....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MGCSTSTHASPEADEDAP
L
K
R
S
V
YSASRTSDQVVSGRQNSNKDQTNDACTAVSENPSRTRSSSDTEGRAHGRGIGAIHY
P
N
QLGKDECDGGED
E
V
V
V
IPPSADKSTR
T
R
F
TFP
Q
R
T
L
L
NVGSHTQAGDSGERKRNSITASP
S
S
F
T
A
M
Q
R
RLSDGSHGHSSFTTMSPAPPDAKETP
L
Q
L
TQTRALPTAATI
P
T
A
C
LSISPP
Q
R
LSIPANSFAGSSASASG
A
V
ALPSQEQHQIETPHVNDGG
F
S
I
E
WDEEDNTPRGRGIPDSTTTESGPCSVTRGMMAPSGSFGIGVGGGWRSKSP
K
W
I
D
L
SRKRSQS
T
V
S
L
L
S
LADTPNN
P
H
VLSSGSD
F
G
R
D
ILGGSH
V
F
G
G
L
ATGGGSSRPQSGYA
M
G
R
D
M
C
V
E
R
F
D
Q
Q
R
HSN
G
L
A
V
F
CNQP
R
E
C
A
L
CRN
A
T
A
A
F
A
C
E
V
C
D
D
F
F
L
C
ENCRF
D
L
E
A
V
CAVHDP
T
H
A
I
L
Y
M
QDNHYNSSRTFGGD
S
I
F
S
LSGDGG
V
S
S
L
F
YN
P
C
F
K
C
K
R
V
IDD
V
E
P
V
Y
RCDQC
D
Y
I
V
C
Q
E
C
F
IQHEEPG
N
A
M
E
R
A
S
S
L
S
A
A
M
A
A
T
R
E
EQASCKPLPIE
S
A
A
L
V
L
ASGPMPP
H
E
H
E
L
K
R
F
Q
R
KSRSNSVHE
G
A
V
V
T
K
TRNSGG
N
--
K
V
I
N
D
Y
V
V
V
R
QIGHGS
Y
A
K
V
K
L
V
Q
H
V
H
T
Q
E
L
F
A
L
K
I
L
R
R
Q
K
K
A
A
MSGITL
G
R
S
R
V
K
S
A
MAGI
S
E
-----
D
D
L
L
---
R
E
I
A
V
M
K
FI-GHP
N
V
V
K
L
K
E
V
I
E
D----V----DS
Q
K
V
Y
I
I
M
E
Y
CEKG
P
V
--
H
V
LGD-----P------A----L-
P
L
--
E
Q
V
R
Q
Y
G
A
D
I
L
R
G
L
L
H
L
H
S
-
E
F
L
Y
HRDIK
P
A
N
C
L
V---NR-D---
S
V
V
K
I
A
DFGTC--
N
----
S
-
Q
I
----
R
-----
T
K
LAE---GTPAFS
C
P
E
Q
VRG-----EE---VS
G
E
V
V
D
S
W
A
F
A
L
T
V
Y
E
MACGTLPV
S
T
T
S
F
V
Q
H
R
S
-
L
L--MSKS----------------------------P--V--PIP--KIG
D
--
E
P
L
C
D
-
L
L
A
Q
M
L
E
K
D
L
S
K--RL-----L-----LPAATRH
P
F
F
A
E
---
C
H
V
D
V
HGAVPGTA
P
R
S
I
F
A
V
L
ATSGGSAAAQ
P
Q
Q
Q
Q
L
P
S
L
A
E
L
Y
D
K
A
L
E
S
V
H-------RGK
N
L
K
D
C
F
H
G
V
R
A
L
R
R
V
R
R
K
E
V
E
T
ARHSGTGDQVGGGSAGAEKS
S
A
Y
V
MNSRDVYGGSDGSGSDGEDEEGAG
R
---
L
W
VGGRAG
H
K
E
E
A
A
A
A
A
A
V
E
E
A
V
E
H
HLFTQEPK
L
E
L
A
Q
V
T
LTA
P
A
T
L
E
K
L
N
R
L
H
Q
V
T
A
E
M
RLSHN
A
L
V
R
LAPL
R
L
S
T
F
S
M
L
M
D
I
A
V
T
F
N
R
L
E
A
I
P
Q
E
V
L
AAP
R
L
V
R
L
DLSHN
R
I
DSI
P
G
S
L
V
T
K
A
L
F
L
E
R
L
S
L
H
H
N
L
I
TSVG
T
T
T
I
T
V
VEPS
P
V
T
F
RVPTS
A
T
A
T
CMGS
N
M
V
AVP
D
A
S
V
V
S
SSITQTSLPGRGGS
S
R
S
K
V
V
S
V
L
A
A
P
C
L
R
H
VRLSG
N
P
L
E
RL
P
D
A
L
E
T
T
H
K
L
Q
L
V
L
D
A
I
P
A
L
M
E
Q
W
D
T
H
MQADSKPTTSTAAAATGGQSR
L
P
A
V
I
V
WDDSF
P
V
RIPSVE
P
A
V
W
L
A
VN
N
V
A
I
Y
R
V
Q
T
L
R
L
C
QT
R
R
V
V
L
C
QCADPRFPNGL
F
L
S
E
E
L
E
V
Y
F
A
A
L
S
K
A
L
Q
D
C
R
E
Q
R
Q
Q
L
AVEAPFSLSA
P
A
EAIPSEALP
P
I
V
G
K
A
A
R
N
Y
V
E
S
Y
F
F
V
TDDENEEEG
G
Y
H
S
L
V
S
Y
L
Y
D
S
LSANI
P
V
L
V
V
V
VSSGTS
C
A
V
R
T
N
I
V
A
A
I
S
T
C
L
T
R
LRGG
D
P
E
QL
D
A
E
Q
A
E
L
I
V
S
T
M
R
S
LYA
51
Fugue
79.77
16%
-
- C1 -
-
3QA8
-
?
A:
[16-666]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
K
E
R
L
G
T
G
G
F
G
Y
V
L
R
W
I
H
Q
D
T
G
E
Q
V
A
I
K
------------------
Q
C
R
Q
E
L
S
P
K
N
R
-----
E
R
W
C
---
L
E
I
Q
I
M
K
K
L
-
N
H
P
N
V
V
S
A
R
E
V
P
D
G
LQKL
A
----
P
N
D
L
P
L
L
A
M
E
Y
C
E
G
G
D
L
R
-
K
Y
L
N
Q
-----
F
------
E
NCCG
L
-
K
E
--
G
P
I
R
T
L
L
S
D
I
S
S
A
L
R
Y
L
H
E
-
N
R
I
I
H
R
D
L
K
P
E
N
I
V
L
QPG
P
Q
-
R
---
L
I
H
K
I
I
D
L
G
Y
A
--
K
----
E
-
L
D
----
Q
-----
G
E
L
C
T
EFV
G
T
L
Q
Y
L
A
P
E
L
L
E
Q
-----
K
K
----
Y
T
V
T
V
D
Y
W
S
F
G
T
L
A
F
E
C
I
T
G
F
R
P
-----
F
L
P
N
W
Q
-
P
V
--
Q
W
H
G
----------------------------
K
--
V
--
R
I
V
--
V
Y
D
D
--
L
T
G
-----
A
V
K
F
S
S
V
L
P
T
--
P
N
-----
H
-----
L
S
G
I
L
A
G
K
L
-------------------
E
R
W
L
Q
C
M
L
M
W
H
Q
R
T
D
P
Q
N
P
N
V
G
C
F
Q
A
L
D
S
I
L
S
L
K
L
L
S
V
M
-------
N
M
V
S
G
R
V
H
T
Y
P
V
T
E
N
E
N
L
Q
N
L
K
S
W
L
Q
Q
D
T
G
I
-----------
P
E
E
E
Q
E
L
L
Q
A
S
G
L
A
L
N
S
A
Q
P
L
T
Q
Y
V
I
D
C
T
V
G
D
L
I
F
L
F
D
N
R
K
I
S
L
P
A
H
P
E
S
V
S
I
V
L
Q
D
P
K
R
P
L
T
Y
T
H
L
R
R
V
W
G
Q
I
W
Q
T
I
R
A
L
K
E
D
C
A
R
L
L
Q
G
Q
R
T
S
------
M
V
N
L
L
R
Y
N
T
E
L
S
K
K
K
N
S
M
T
S
E
C
E
Q
L
K
A
K
L
D
F
F
R
S
S
I
Q
I
D
L
E
K
Y
S
E
Q
M
E
F
G
I
T
S
E
--
K
L
L
S
A
W
R
E
M
E
Q
A
V
E
L
C
G
R
E
R
E
V
Q
A
L
V
D
K
M
M
A
L
Q
T
D
S
V
D
L
Q
R
N
P
T
L
D
D
L
E
E
Q
A
R
D
L
Y
R
R
L
R
E
R
P
R
D
Q
R
T
P
G
D
S
N
D
M
V
R
L
L
I
L
A
I
Q
S
F
E
K
R
V
I
L
I
Y
D
Q
L
S
K
T
V
V
C
K
R
K
A
L
E
L
S
P
K
V
K
E
V
M
N
L
M
R
E
D
E
K
I
V
V
R
R
Q
E
K
R
Q
Q
E
L
W
N
L
L
K
I
A
C
S
K
V
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
79.24
28%
-61
- C1 -
-
4CQG
1
MELK_MOUSE
A:
[5-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
--
E
L
L
K
Y
Y
E
L
Y
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
V
L
T
G
E
M
V
A
I
K
I
M
--
D
K
N
A
L
G
S
D
L
----
P
R
V
K
T
--------------------
E
I
D
A
L
K
S
L
-
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
----------
K
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
-----
D
------
R
----
L
-
S
E
--
E
E
T
R
V
V
F
R
Q
I
L
S
A
V
A
Y
V
H
S
-
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
-
N
---
H
K
L
K
L
I
D
F
G
L
C
AK-----------------------
C
---
G
S
L
A
Y
A
A
P
E
L
I
Q
G
-------------
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
M
A
L
Y
K
-
K
I
--
M
-
R
G
----------------------------
K
--
Y
--
E
V
P
--
K
W
L
S
--
P
S
S
I
L
-
L
L
Q
Q
M
L
Q
V
D
P
K
K
--
R
I
-----
S
-----
M
R
N
L
L
N
H
P
W
V
M
Q
DYS
C
P
V
E
W
Q
S
K
T
P
L
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
79.06
28%
-59
- C1 -
-
4BFM
1
MELK_MOUSE
A:
[5-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
--
E
L
L
K
Y
Y
E
L
Y
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
V
L
T
G
E
M
V
A
I
K
I
M
--
D
K
N
A
L
G
S
D
L
----
P
R
V
K
T
--------------------
E
I
D
A
L
K
S
L
-
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
----------
K
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
-----
D
------
R
----
L
-
S
E
--
E
E
T
R
V
V
F
R
Q
I
L
S
A
V
A
Y
V
H
S
-
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
-
N
---
H
K
L
K
L
I
D
F
G
L
C
AK-----------------------
C
---
G
S
L
A
Y
A
A
P
E
L
I
Q
G
-------------
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
M
A
L
Y
K
-
K
I
--
M
-
R
G
----------------------------
K
--
Y
--
E
V
P
--
K
W
L
S
--
P
S
S
I
L
-
L
L
Q
Q
M
L
Q
V
D
P
K
K
--
R
I
-----
S
-----
M
R
N
L
L
N
H
P
W
V
M
Q
DYS
C
P
V
E
W
Q
S
K
T
P
L
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
75.67
32%
-44
- C1 -
-
2ZV2
1
KKCC2_HUMAN
A:
[10-295]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
L
N
Q
Y
T
L
K
D
E
I
G
K
--
Y
G
V
V
K
L
A
Y
N
E
N
D
N
T
Y
Y
A
M
K
V
L
S
K
K
-----------------------------
E
Q
V
Y
---
Q
E
I
A
I
L
K
K
L
-
D
H
P
N
V
V
K
L
V
E
V
L
D
D
----
P
----
N
E
D
H
L
Y
M
V
F
E
L
V
N
Q
G
P
V
--
M
E
V
-------
P
------
T
----
L
K
P
L
S
E
D
Q
A
R
F
Y
F
Q
D
L
I
K
G
I
E
Y
L
H
Y
-
Q
K
I
I
H
R
D
I
K
P
S
N
L
L
V
---
G
E
-
D
---
G
H
I
K
I
A
D
F
G
V
S
--
N
E
F
K
G
S
-
D
A
----
L
-----
L
S
N
T
V
---
G
T
P
A
F
M
A
P
E
S
L
S
E
-----
T
R
K
I
-
F
S
G
K
A
L
D
V
W
A
M
G
V
T
L
Y
C
F
V
F
G
Q
C
P
F
M
D
E
R
I
M
C
L
H
S
-
K
I
--
K
S
Q
A
-------------------------------
L
--
E
F
P
--
D
Q
P
D
IA
E
D
L
K
D
-
L
I
T
R
M
L
D
K
N
P
E
S
--
R
I
-----
V
-----
V
P
E
I
K
L
H
P
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
74.87
28%
-52
- C1 -
-
5K00
1
MELK_HUMAN
A:
[6-268]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
--
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
N
T
L
G
------------------
S
D
L
-----
P
R
I
K
---
T
E
I
E
A
L
K
N
L
-
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
----------
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
--
F
D
Y
I
I
-----
S
Q
D----
R
----
L
-
S
E
--
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
-
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
-
Y
---
H
K
L
K
L
I
D
F
G
L
C
--
A
----
K
-
P
--------------------
S
L
A
Y
A
A
P
E
L
I
Q
G
-----
K
S
---
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
M
A
L
Y
K
-
K
I
--
M
R
-
G
----------------------------
K
--
Y
--
D
V
P
--
K
W
L
S
--
P
S
S
I
L
-
L
L
Q
Q
M
L
Q
V
D
P
K
K
--
R
I
-----
S
-----
M
K
N
L
L
N
H
P
W
I
M
Q
---
D
Y
N
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
71.69
33%
-16
- C1 -
-
5UYJ
1
KKCC2_HUMAN
A:
[4-287]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
Q
Y
T
L
K
D
E
I
G
K
G
S
Y
G
V
V
K
L
A
Y
N
E
N
D
N
T
Y
Y
A
M
K
V
L
S
K
K
K
L
I
R
Q
A
G
F
P
R
R
P
P
--------
C
I
Q
PRGPI
E
Q
V
Y
---
Q
E
I
A
I
L
K
K
L
-
D
H
P
N
V
V
K
L
V
E
V
L
D
D
----
P
----
N
E
D
H
L
Y
M
V
F
E
L
V
N
Q
G
P
V
--
M
E
V
-------
P
------
T
----
L
K
P
L
S
E
D
Q
A
R
F
Y
F
Q
D
L
I
K
G
I
E
Y
L
H
Y
-
Q
K
I
I
H
R
D
I
K
P
S
N
L
L
V
---
G
E
-
D
---
G
H
I
K
I
A
D
F
G
V
S
--
N
E
F
K
G
S
-
D
A
----
L
-----
L
S
N
T
V
---
G
T
P
A
F
M
A
P
E
S
L
S
E
-----
T
R
K
I
-
F
S
G
K
A
L
D
V
W
A
M
G
V
T
L
Y
C
F
V
F
G
Q
C
P
F
M
D
E
R
I
M
C
L
H
S
-
K
I
--
K
S
Q
A
-------------------------------
L
--
E
F
P
--
D
Q
P
D
IA
E
D
L
K
D
-
L
I
T
R
M
L
D
K
N
P
E
S
--
R
I
-----
V
-----
V
P
E
I
K
L
H
P
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
69.67
33%
-12
- C1 -
-
5UY6
1
KKCC2_HUMAN
A:
[4-287]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
Q
Y
T
L
K
D
E
I
G
K
G
S
Y
G
V
V
K
L
A
Y
N
E
N
D
N
T
Y
Y
A
M
K
V
L
S
K
K
K
L
I
R
Q
A
G
F
P
R
R
P
P
P
------
G
C
I
Q
PRGPI
E
Q
V
Y
---
Q
E
I
A
I
L
K
K
L
-
D
H
P
N
V
V
K
L
V
E
V
L
D
D
----
P
----
N
E
D
H
L
Y
M
V
F
E
L
V
N
Q
G
P
V
--
M
E
V
-------
P
------
T
----
L
K
P
L
S
E
D
Q
A
R
F
Y
F
Q
D
L
I
K
G
I
E
Y
L
H
Y
-
Q
K
I
I
H
R
D
I
K
P
S
N
L
L
V
---
G
E
-
D
---
G
H
I
K
I
A
D
F
G
V
S
--
N
E
F
K
G
S
-
D
A
----
L
-----
L
S
N
T
V
---
G
T
P
A
F
M
A
P
E
S
L
S
E
-----
T
R
K
I
-
F
S
G
K
A
L
D
V
W
A
M
G
V
T
L
Y
C
F
V
F
G
Q
C
P
F
M
D
E
R
I
M
C
L
H
S
-
K
I
--
K
S
Q
A
-------------------------------
L
--
E
F
P
--
D
Q
P
D
IA
E
D
L
K
D
-
L
I
T
R
M
L
D
K
N
P
E
S
--
R
I
-----
V
-----
V
P
E
I
K
L
H
P
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
69.22
26%
-54
- C1 -
-
3C0I
1
CSKP_HUMAN
A:
[22-295]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
S
--------------
P
G
L
S
T
-----
E
D
L
K
---
R
E
A
S
I
C
H
M
L
-
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
----------
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
--
C
F
E
I
V
-----
K
R
A
D
A
G
F
V
----
Y
-
S
E
--
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
-
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
---
A
S
-
K
ENS
A
P
V
K
L
G
G
F
G
V
A
--
I
----
Q
-
L
G
----
E
SGLV-
A
G
G
R
V
---
G
T
P
H
F
M
A
P
E
V
V
K
R
-----
E
P
---
Y
-
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
K
E
R
-
L
F
E
-
G
I
--
I
K
G
K
Y
---------------------------
K
M
N
P
--
R
Q
W
--
S
H
I
S
--
E
S
A
K
D
-
L
V
R
R
M
L
M
L
D
P
A
E
--
R
I
-----
T
-----
V
Y
E
A
L
N
H
P
W
L
K
E
---
R
D
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
HHSearch
69.21
26%
-55
- C1 -
-
3C0G
1
CSKP_HUMAN
B:
[22-295]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
S
--------------
P
G
L
S
T
-----
E
D
L
K
---
R
E
A
S
I
C
H
M
L
-
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
----------
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
--
C
F
E
I
V
-----
K
R
A
D
A
G
F
V
----
Y
-
S
E
--
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
-
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
---
A
S
-
K
ENS
A
P
V
K
L
G
G
F
G
V
A
--
I
----
Q
-
L
G
----
E
SG
L
V
-
A
G
G
R
V
---
G
T
P
H
F
M
A
P
E
V
V
K
R
-----
E
P
---
Y
-
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
K
E
R
-
L
F
E
-
G
I
--
I
K
G
K
Y---------------------------
K
MN
P
--
R
Q
W
--
S
H
I
S
--
E
S
A
K
D
-
L
V
R
R
M
L
M
L
D
P
A
E
--
R
I
-----
T
-----
V
Y
E
A
L
N
H
P
W
L
K
E
---
R
D
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
68.61
27%
-3
- C1 -
-
4YOM
2
?
B:
[13-322]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HA
Q
Y
V
G
P
Y
R
L
E
K
T
L
G
K
G
Q
T
G
L
V
K
L
G
I
H
C
V
T
C
Q
K
V
A
I
K
I
V
N
R
E
K
--------------------
L
S
E
-----
S
V
L
M
K
V
E
R
E
I
A
I
L
K
L
I
-
E
H
P
H
V
L
K
L
H
D
V
Y
E
N
----------
K
K
Y
L
Y
L
V
L
E
H
V
S
G
G
E
L
F
D
Y
L
V
K
K
-----
G
------
R
----
L
-
T
P
--
K
E
A
R
K
F
F
R
Q
I
I
S
A
L
D
F
C
H
S
-
H
S
I
C
H
R
D
L
K
P
E
N
L
L
L
---
D
E
-
R
---
N
N
I
R
I
A
D
F
G
M
A
--
S
----
L
-
Q
V
----
G
-----
D
S
L
L
E
TSC
G
S
P
H
Y
A
C
P
E
V
I
R
G
-----
E
K
---
Y
D
G
R
K
A
D
V
W
S
C
G
V
I
L
F
A
L
L
V
G
A
L
P
F
D
D
D
N
L
---
R
Q
-
L
L
E
K
V
K
R
G
----------------------------
V
--
F
--
H
M
P
--
H
F
I
P
--
P
D
C
Q
S
-
L
L
R
G
M
I
E
V
D
A
A
R
--
R
L
-----
T
-----
L
E
H
I
Q
K
H
I
W
Y
I
G
---
G
K
N
------------
K
V
---------------
Q
I
R
S
L
P
S
L
E
D
I
D
P
D
V
L
D
S
M
H
S
LGCFRD
R
N
K
L
L
Q
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
HHSearch
66.80
29%
-50
- C1 -
-
4WOT
1
ROCK2_HUMAN
B:
[66-342]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
A
E
D
Y
D
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
A
S
Q
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
----------------
R
S
D
S
-----
A
F
F
W
---
E
E
R
D
I
M
A
F
A
-
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
----------
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
--
V
N
L
M
S
-----
N
Y
-----
D
----
V
-
P
E
--
K
W
A
K
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
L
I
H
R
D
V
K
P
D
N
M
L
L
---
D
K
-
H
---
G
H
L
K
L
A
D
F
G
T
C
--
M
----
K
-
M
D
----
E
TG
M
V
H
C
D
T
A
V
---
G
T
P
D
Y
I
S
P
E
V
L
K
S
-----
Q
G
GDG
F
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
-
K
I
--
M
D
H
K
N---------------------------
S
--
L
CF
P
E
D
--
A
E
I
S
--
K
H
A
K
N
-
L
I
C
A
F
L
T
D
R
E
V
R
LG
R
N
-----
G
-----
V
E
E
I
R
Q
H
P
F
F
K
N
---
D
Q
W
H
W
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
65.88
33%
-12
- C1 -
-
5VT1
1
KKCC2_HUMAN
A:
[4-287]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
Q
Y
T
L
K
D
E
I
G
K
G
S
Y
G
V
V
K
L
A
Y
N
E
N
D
N
T
Y
Y
A
M
K
V
L
S
K
K
K
L
I
R
Q
A
------------------RG
P
I
-
E
Q
V
Y
---
Q
E
I
A
I
L
K
K
L
-
D
H
P
N
V
V
K
L
V
E
V
L
D
D
----
P
----
N
E
D
H
L
Y
M
V
F
E
L
V
N
Q
G
P
V
--
M
E
V
-------
P
------
T
----
L
K
P
L
S
E
D
Q
A
R
F
Y
F
Q
D
L
I
K
G
I
E
Y
L
H
Y
-
Q
K
I
I
H
R
D
I
K
P
S
N
L
L
V
---
G
E
-
D
---
G
H
I
K
I
A
D
F
G
V
S
--
N
E
F
K
G
S
-
D
A
----
L
-----
L
S
N
T
V
---
G
T
P
A
F
M
A
P
E
S
L
S
--------KI-
F
S
G
K
A
L
D
V
W
A
M
G
V
T
L
Y
C
F
V
F
G
Q
C
P
F
M
D
E
R
I
M
C
L
H
S
-
K
I
--
K
S
Q
A
-------------------------------
L
--
E
F
P
--
D
Q
P
D
IA
E
D
L
K
D
-
L
I
T
R
M
L
D
K
N
P
E
S
--
R
I
-----
V
-----
V
P
E
I
K
L
H
P
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
64.84
31%
-49
- C- -
-
3FE3
-
MARK3_HUMAN
A:
[53-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
R
E
V
A
I
K
I
I
D
-----------------
K
T
Q
L
N
P
T
S
L
-----
Q
K
L
F
---
R
E
V
R
I
M
K
I
L
-
N
H
P
N
I
V
K
L
F
E
V
I
E
T
----------
E
K
T
L
Y
L
I
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
-----
G
------
R
----
M
-
K
E
--
K
E
A
R
S
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
-
K
R
I
V
H
R
D
L
K
A
E
N
L
L
L
---
D
A
-
D
---
M
N
I
K
I
A
D
F
G
F
S
--
N
----
E
F
T
V
----
G
-----
G
K
L
D
A
FC-
G
A
P
P
Y
A
A
P
E
L
F
Q
G
-----
K
K
---
Y
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
Q
N
L
K
E
L
R
E
R
V
L
--
R
G
K
Y
----------------------------
R
--
I
--
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
64.60
25%
-54
- C1 -
-
1J1B
1
GSK3B_HUMAN
B:
[52-345]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
K
----------------------------
R
F
K
N
---
R
E
L
Q
I
M
R
K
L
-
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
----
S
GEKK
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
--
R
V
A
R
H
Y
S
R
A
K
Q
------
T
----
L
-
P
V
--
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
-
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
---
D
P
D
T
---
A
V
L
K
L
C
D
F
G
S
A
--
K
----
Q
-
L
V
----
R
G
E
P
--
N
V
S
Y
I
---
C
S
R
Y
Y
R
A
P
E
L
I
F
G
-----
A
T
---
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
-
E
I
--
I
K
V
L
GTPT
R
E
Q
I
R
E
M
NPNYTEFKFPQIKAHP
W
T
--
K
--
V
F
R
--
P
R
T
P
--
P
E
A
I
A
-
L
C
S
R
L
L
E
Y
T
P
T
A
--
R
L
-----
T
-----
P
L
E
A
C
A
H
S
F
F
D
E
---
L
R
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
63.60
29%
-14
- C1 -
-
4GV1
5
AKT1_HUMAN
A:
[6-280]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
T
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
K
----------------
D
E
V
-----
A
H
T
L
---
T
E
N
R
V
L
Q
N
S
-
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
----------
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
--
F
F
H
L
S
-----
R
E
R----
V
----
F
-
S
E
--
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
---
D
K
-
D
---
G
H
I
K
I
T
D
F
G
L
C
--
K
----
E
-
G
I
KDGA
T
-----
M
K
T
F
C
---
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
D
---
Y
-
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
E
K
L
F
E
-
L
I
--
L
M
-
E
----------------------------
E
--
I
--
R
F
P
--
R
T
L
G
--
P
E
A
K
S
-
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
GGGS
E
D
-----
A
K
E
I
M
Q
H
R
F
F
A
G
---
I
V
W
Q
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
HHSearch
63.46
27%
0
- C- -
-
1FOT
-
KAPA_YEAST
A:
[83-364]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
Q
D
F
Q
I
L
R
T
L
G
T
G
S
F
G
R
V
H
L
I
R
S
R
H
N
G
R
Y
Y
A
M
K
V
L
K
K
E
I
V
V
R
L
----------------
K
Q
V
-----
E
H
T
N
---
D
E
R
L
M
L
S
I
V
-
T
H
P
F
I
I
R
M
W
G
T
F
Q
D
----------
A
Q
Q
I
F
M
I
M
D
Y
I
E
G
G
E
L
--
F
S
L
L
R
-----
K
S
Q----
R
----
F
-
P
N
--
P
V
A
K
F
Y
A
A
E
V
C
L
A
L
E
Y
L
H
S
-
K
D
I
I
Y
R
D
L
K
P
E
N
I
L
L
---
D
K
-
N
---
G
H
I
K
I
T
D
F
G
F
A
--
K
----
Y
-
V
P
----
D
V----
T
Y
T
L
C
---
G
T
P
D
Y
I
A
P
E
V
V
S
T
-----
K
P
---
Y
-
N
K
S
I
D
W
W
S
F
G
I
L
I
Y
E
M
L
A
G
Y
T
P
F
Y
D
S
N
T
M
K
T
Y
E
-
K
I
--
L
N
-
A
----------------------------
E
--
L
--
R
F
P
--
P
F
F
N
--
E
D
V
K
D
-
L
L
S
R
L
I
T
R
D
L
S
Q
--
R
L
-----
G
NLQNG
T
E
D
V
K
N
H
P
W
F
K
E
---
V
V
W
E
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
62.79
31%
-36
- C1 -
-
3IEC
-
MARK2_HUMAN
A:
[6-248]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
N
Y
R
L
L
K
T
I
G
----
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
I
D
-----------------
K
T
Q
L
N
S
S
S
L
-----
Q
K
L
F
---
R
E
V
R
I
M
K
V
L
-
N
H
P
N
I
V
K
L
F
E
V
I
E
T
----------
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
-----
G
------
W
----
M
-
K
E
--
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
-
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
---
D
A
-
D
---
M
N
I
K
I
A
D
F
G
F
S
--
N
----
E
F
T
F
----
G
-----
N
K
L
D
T
FC-
G
S
P
P
Y
A
A
P
E
L
F
Q
G
-----
K
K
---
Y
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
Q
N
L
K
E
L
R
E
R
V
L
--
R
G
K
Y
----------------------------
R
--
I
--
P
F
Y
--
M
S
T
D
-----
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
--
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
62.48
24%
-32
* C1 *
-
2Y7J
1
PHKG2_HUMAN
D:
[91-364]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
Y
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
V
---
R
L
S
P
-----------
E
Q
L
E
E
V
R
-----
E
A
T
R
---
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
----------
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
--
F
D
Y
L
T
-----
E
KV----
A
----
L
-
S
E
--
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
-
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
---
D
D
-
N
---
M
Q
I
R
L
S
D
F
G
F
S
--
C
----
H
-
L
E
PGE-
K
-----
L
R
E
L
C
---
G
T
P
G
Y
L
A
P
E
I
L
K
C
SMDET
H
P
---
G
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
R
R
Q
I
L
M
L
R
-
M
I
--
M
E
G
Q
Y---------------------------
Q
--
F
--
S
S
P
EW
D
D
R
S
--
S
T
V
K
D
-
L
I
S
R
L
L
Q
V
D
P
E
A
--
R
L
-----
T
-----
A
E
Q
A
L
Q
H
P
F
F
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
60.25
26%
-64
- C1 -
-
4JXF
2
PLK4_HUMAN
A:
[5-264]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
E
D
F
K
V
G
N
L
L
G
K
G
S
F
A
G
V
Y
R
A
E
S
I
H
T
G
L
E
V
A
I
K
M
I
D
K
K
A
M
Y
K
----------------
A
G
M
V
-----
Q
R
V
Q
---
N
E
V
K
I
H
C
Q
L
-
K
H
P
S
I
L
E
L
Y
N
Y
F
E
D
----------
S
N
Y
V
Y
L
V
L
E
M
C
H
N
G
E
M
--
N
R
Y
L
K
-----
N
RVK---
P
----
F
-
S
E
--
N
E
A
R
H
F
M
H
Q
I
I
T
G
M
L
Y
L
H
S
-
H
G
I
L
H
R
D
L
T
L
S
N
L
L
L
---
T
R
-
N
---
M
N
I
K
I
A
D
F
G
L
A
--
T
----
Q
-
L
K
----
M
PHE--------------------------------------
S
D
V
W
S
L
G
C
M
F
Y
T
L
L
I
G
R
P
P
F
----
V
K
N
T
L
N
-
K
V
--
V
L
-
A
----------------------------
D
--
Y
--
E
M
P
--
S
F
L
S
--
I
E
A
K
D
-
L
I
H
Q
L
L
R
R
N
P
A
D
--
R
L
-----
S
-----
L
S
S
V
L
D
H
P
F
M
S
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
59.80
24%
-31
- C1 -
-
2Y7J
1
PHKG2_HUMAN
C:
[91-364]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
Y
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
V
T
A
E
R
L
S
P
------
E
-----
Q
L
E
E
V
R
-----
E
A
T
R
---
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
----------
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
--
F
D
Y
L
T
-----
E
KV----
A
----
L
-
S
E
--
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
-
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
---
D
D
-
N
---
M
Q
I
R
L
S
D
F
G
F
S
--
C
----
H
-
L
E
----
P
GEK--
L
R
E
L
C
---
G
T
P
G
Y
L
A
P
E
I
L
K
C
SMDET
H
P
---
G
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
R
R
Q
I
L
M
L
R
-
M
I
--
M
E
G
Q
Y---------------------------
Q
--
F
--
S
S
P
EW
D
D
R
S
--
S
T
V
K
D
-
L
I
S
R
L
L
Q
V
D
P
E
A
--
R
L
-----
T
-----
A
E
Q
A
L
Q
H
P
F
F
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
59.41
31%
-39
- C1 -
-
5KZ8
1
MARK2_HUMAN
A:
[32-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
I
D
-----------------
K
T
Q
L
N
S
S
S
L
-----
Q
K
L
F
---
R
E
V
R
I
M
K
V
L
-
N
H
P
N
I
V
K
L
F
E
V
I
E
T
----------
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
-----
G
------
R
----
M
-
K
E
--
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
-
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
---
D
A
-
D
---
M
N
I
K
I
A
D
F
G
----------------------------C--
G
S
P
P
Y
A
A
P
E
L
F
Q
G
-----
K
K
---
Y
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
Q
N
L
K
E
L
R
E
R
V
L
--
R
G
K
Y
----------------------------
R
--
I
--
P
F
Y
--
M
S
T
D
-----
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
--
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
57.32
30%
-49
- C1 -
-
5ES1
1
MARK4_HUMAN
A:
[14-234]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
G
N
Y
R
L
L
R
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
R
E
V
A
I
K
I
I
D
-----------------
K
T
Q
L
N
P
S
S
L
-----
Q
K
L
F
---
R
E
V
R
I
M
K
G
L
-
N
H
P
N
I
V
K
L
F
E
V
I
E
T
----------
E
K
T
L
Y
L
V
M
E
Y
A
S
A
G
E
V
F
D
Y
L
V
S
H
-----
G
------
R
----
M
-
K
E
--
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
H
Y
C
H
Q
-
K
N
I
V
H
R
D
L
K
A
E
N
L
L
L
---
D
A
-
E
---
A
N
I
K
I
A
D
F
G
F
S
--
N
---------------------------
S
P
P
Y
A
A
P
E
L
F
Q
G
-----
K
K
---
Y
D
G
P
E
V
D
I
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
H
N
L
K
E
L
R
E
R
V
L
--
R
G
K
Y
----------------------------
R
--
V
--
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------