@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_24_2090: (2018-03-10 )
MTSTSVALIASVLRQPRVGDDLQWVRYDAPFRTAQDYAAAEYLYRLRLCSLRLRSSLLSPSLPRTGPVSEVAHLLPHYPVQITAQLVYMDEPLSPVVESAAVYASAAALLPPASPVGGDTDTHAEMEVVYTFTDEWLVFPLELCDVPLDASCKLHLWHRDTHVAEAALHVYSVAGELCVGQRQLALSTGGDAPSDEQLWSTSTRAAELLADFHRGMMPPIPWLDTLSIQQLEAEHARHGNAVVRRGSPQSAKDPCGAPTAILTLYLPAATTAVFFEPGVARVSDDMKSLLQHSDAADDSCDFTQRPFPDQYTFFKEHNLCEAKAAITSKTQYFLSDSSAPPGPKERHQLASLLRRPPIQLDNVAGAVVTGAGAGGVGGGRLEETRLLWKYRHFICRDGKYFLPFMRCVDWANTHSSERRAACALIYQWARPAFEDVLACLSFYFDHVAPVRQYAVRLLRREGDGRLCQLAFQLVQAVRYDSAEAELANFLVERAVGCWELCSTLYTLLSVEVALEKRRTLSAAGKASDDRHGGRALFEPLLRRLSERLTQQCPHFATRLRQQHAMHRVLQLLSRQLQQSSLDRLGKTALGNKLIAKQACGLRALFSSVHHGMPSRRNVNGSFSSSLMTHSSAGMREEHSMSSARTGDGSEEADANGGDGSSAVEASDVDSAADDEVRRLRFPPLSPQSQGSAPRSPPSQSGAKQQYRSRHASAVDVLDRYGVATLATHPGIPITGLLSDSLYIFKSAKLPMRLTFTALRPAGLAWGGGRGGEPLYGASPSPCLLTPLAMQPAPSQQRSGGLQGMNSSGGGASAAVAAEEQAEGFLGAGEGDTVPLAMMYKYNDDIRQDQLIVQLIRLMDDLLQRDGLQLYLTPYRVIATAPNEGLVEIVPQVTTFFSVQRDVLKYLRVYNSTAELLRQAMDRYTRSFAGYCVITFVLGIGDRHLENILITQDGRLLHIDFGYVLGNDPKPFPPPMKINREMVEVLGGPQSTGFTEFKLYCCSAYNTLRKHAPLLLHILLLGAHTEGMPQVTGEGGDPRVNLLKVQEKLRLDLTNAQATQYLQNVIADSVGSIFTNLWDVLHAAAQATRG
Atome Classification :
(20 SA)
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........10........20......-..30........40.....--...50........60.......--.70.----------.......80......--.----.90........100.......110.......120....-...130.......140..-------.....150......----------.---------160...-----....--170.-....--.--------.180--------........190..---.....200........210.......220-.........230.....-..240.......250.......260---.......270-..-......280.........290--.-.......300...------....310.......320.......330....-....340------..---......350.-......360......-----.370.......380.......390....-...400.......410.......420.......430........440...--..--..450.......460-..-......470.......--480.------------------.----------------------------.-.....490.......500.......510.....----..520...-....530.......540.......550-.---........560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......-730......--.740....-...750......--.760.......770.......780.......790.......800.......810...--....820.......830.......840.......850.......860.......870.......880.......890..------.......------900---.------------........----910-.----..----.----....920.......930.......940.......950........960---........970---.......-..980.....---.-----.990.-......1000......1010......1020......-1030......1040......1050......1060......-1070.......1080......---------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MTS
T
S
V
A
L
I
A
S
V
L
RQPRVGDDL
Q
W
V
RY-DAPFR
T
A
Q
D
Y
A
A
A
E
Y
L
Y
R
L
--
R
L
C
S
L
R
L
R
S
S
LLSPSLPRTG
P
V
--
S
E
V
A
----------
H
L
LPHYP
V
Q
I
T
A
Q
L
V
--
Y
----MDEP
L
S
P
V
V
E
S
A
A
V
Y
A
S
A
A
ALLPPASPVGGDTDTHA
E
M
-
E
V
V
Y
T
FTDE
W
L
V
F
P
L
E
LC-------DVPLDAS
C
K
L
H
L
W
H----------R---------D
T
H
V
A
E
-----
A
A
L
H
--
V
Y
S
V
-
A
G
E
L--C--------VG
Q
---------
R
Q
L
A
L
STGGDAPS---D
E
Q
LWS-T
S
T
R
A
A
E
L
L
A
D
F
H
RGMMPPI---PWLDT
L
S
I
Q
Q
L
E
A
E
H
AR-HG
N
A
V
V
RRGSPQSAKDPCGAP
T
A
I
L
---
T
L
Y
LPAA
T
-
T
-
A
V
-
F
FEP
G
V
A
--
R
V
S
D
D
M
K
S
L
L
Q---H-SDAADDSCDFTQR------PFPDQY
T
F
F
K
EHNL
C
E
A
K
A
AITSK
T
-
Q
Y
F
L
S-DSSAPP-------G
P
---
K
E
R
H
Q
L
A
S
L
L
-RRPPIQLDNVA
G
A
V
V
-----TGAGAGGVGGGR
L
E
E
T
R
L
L
W
K
Y
R
H
F
I
CR-DG
K
Y
F
L
P
F
M
R
C
V
D
WANTHS
S
E
R
R
A
A
C
A
L
I
Y
Q
WA
R
-
P
A
F
E
D
V
L
A
C
L
S
F
Y
F
D
--
H
V
--
A
P
V
R
Q
Y
A
V
R
L
L
R
R-E-GD-
G
R
L
C
Q
L
A
F
Q
L
V
Q
A
V
RY--D
S
-
A
------------------
E
----------------------------
A
-
E
L
A
N
F
L
V
E
RAV
G
C
W
E
L
C
S
T
L
Y
T
L
L
S
V
E
V
A
L
EKR----RTLSAAGK-ASDDRHG
G
R
A
L
F
E
P
L
L
R
R
L
S
E
R
L
T
Q
---Q---C
P
H
F
A
T
R
L
R
Q
Q
H
A
M
H
R
V
L
Q
L
L
S
R
Q
L
Q
Q
S
S
L
D
R
L
G
K
T
A
LGN
K
L
I
A
K
Q
AC
G
L
R
A
L
F
S
S
V
HHGMPSRRNVNGSF
S
S
S
L
M
THSSAGM
R
E
E
HSMSSARTGDGSEEADANGGDGSSAVEASDVDSAADD
E
V
R
RLRFPPLSPQSQGSAPRSPPSQS
G
A
K
Q
Q
Y
R
S
RH
A
S
A
V
D
V
L
D
RYG
V
A
TLATHP-GI
P
I
T
GLLS--D
S
L
Y
I
F
KS-AKL
P
M
R
L
T
F
T
AL--RPAGLAWGGGRGGEPLYGASPSP
C
L
L
TPLAMQPAP
S
Q
QRSGGLQGMNSSGGGAS
A
A
V--
A
A
E
E
QAEGFLGAGEGD
T
V
P
L
A
M
M
Y
KYNDDI
R
Q
D
Q
L
I
V
Q
L
I
R
L
M
D
D
L
L
Q
RDG
L
Q
L
Y
L
T
P
Y
R
V
I
A
TAPNE
G
L
V
E
I
V
P
--
Q
V
------
T
T
F
F
S
V
Q
------
R
-----
D
------------
V
L
K
Y
L
R
V
Y
----
N
S
--
T
----
A
E
----
L
----
L
R
Q
A
M
D
R
Y
T
R
S
FAG
Y
C
V
I
T
F
V
LGIGD
R
H
L
E
N
I
L
ITQ-DG
R
L
L
H
I
D
F
G
----
Y
VLGNDPKP-----FPP
P
M
KI-
N
R
E
M
V
E
VLGG---P-----QSTGF-
T
E
F
K
L
Y
C
C
S
A
Y
N
T
L
R
K
H
A
P
L
L
L
H
I
L
L
LGAHTEGMPQ-VTGEGGDPR
V
N
L
L
K
V
Q
E
K
L
R
LDLT
N
A
Q
A
T
Q
Y
L
Q
N
V
I
A
D
S
V
-
G
-
S
I
F
T
N
L
W
D
V
L
H
A
A
A
QATRG---------------------
58
Fugue
74.19
28%
-19
- C3 -
-
5DFZ
-
VPS34_YEAST
C:
[4-875]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
-
N
I
T
F
C
V
S
Q
D
L
---
D
V
P
L
K
V
--
K
I
K
S
L
E
G
H
K
P
L
L
K
P
S
Q
K
I
L
N
P
-----------------------
E
L
M
L
I
G
S
N
V
--
F
----
P
S
S
D
L
I
V
S
L
Q
V
F
D
K
E
R
N
R
N
L
T
L
P
I
Y
T
P
Y
I
P
F
R
N
S
R
T
W
---------
D
Y
W
L
T
L
P
I
R
I
K
-------
Q
L
T
F
S
S
H
L
R
I
I
L
W
E
----------
Y
---------
N
G
S
K
Q
I
-----
P
F
F
N
--
L
E
T
S
-
I
F
N
L
KD
C
--------
T
L
K
---------
R
G
F
E
S
L
K
F
R
Y
D
V
I
---
D
H
C
E
V
V
-
T
D
N
K
D
Q
E
N
L
N
K
Y
F
Q
G
E
F
T
R
L
---
P
W
L
D
E
I
T
I
S
K
L
R
K
Q
R
E
N
--------
R
T
W
P
Q
G
--------
T
F
V
L
---
N
L
E
F
P
M
L
E
-
L
-
P
V
V
F
I
E
R
E
I
M
--
N
T
N
D
P
I
E
E
K
Y
R
---
R
-
L
E
R
A
S
K
N
A
N
L
-----------------------------------------
D
K
Q
V
K
P
-------
D
I
---
K
K
R
D
Y
L
N
K
I
I
-
N
Y
P
P
G
T
K
L
T
-----------------------
A
H
E
K
G
S
I
W
K
Y
R
Y
Y
L
M
N
-
N
K
K
A
L
T
K
L
L
Q
S
T
N
--
L
R
E
E
S
E
R
V
E
V
L
E
L
M
D
S
W
A
E
-
I
D
I
D
D
A
L
E
L
L
G
S
T
F
K
--
N
---
L
S
V
R
S
Y
A
V
N
R
L
K
K
-
A
-
S
D
-
K
E
L
E
L
Y
L
L
Q
L
V
E
A
V
C
F
--
E
N
------------------------------------------------------------------------------------------
L
S
T
F
S
D
-
K
S
N
S
E
F
T
I
V
D
A
V
S
P
L
--------------------
A
E
F
L
I
R
R
A
L
V
N
P
R
L
G
S
F
F
Y
W
Y
L
K
S
E
S
E
D
K
-----------------------------
P
Y
L
D
Q
I
L
S
S
F
W
S
R
L
D
K
K
S
R
N
I
L
N
D
Q
-------------------------
V
R
L
I
N
V
L
R
E
C
C
E
T
I
K
R
L
K
----------------
D
T
T
A
K
K
M
E
L
L
V
H
L
L
E
T
K
V
R
P
L
V
K
V
R
P
I
A
L
P
L
D
P
-
D
V
L
I
C
D
V
C
P
--
E
T
S
K
V
F
K
S
-
S
L
S
P
L
K
I
T
F
K
-----------------------------------------------
T
T
L
N
Q
-----------------------------
P
Y
H
L
M
F
K
V
G
D
D
L
R
Q
D
Q
L
V
V
Q
I
I
S
L
M
N
E
L
L
K
N
E
N
V
D
L
K
L
T
P
Y
K
I
L
A
T
G
P
Q
E
G
A
I
E
F
I
P
ND
T
L
------
A
S
I
L
S
K
Y
------
H
-----
G
------------
I
L
G
Y
L
K
L
H
YPDE
N
A
--
T
----
L
G
----
V
----
Q
G
W
V
L
D
N
F
V
K
S
C
A
G
Y
C
V
I
T
Y
I
L
G
V
G
D
R
H
L
D
N
L
L
V
T
P
-
D
G
H
F
F
H
A
D
F
G
----
Y
I
L
G
Q
D
P
K
P
-----
F
P
P
L
M
K
L
-
P
P
Q
I
I
E
A
F
G
G
---
A
-----
E
S
S
N
Y
-
D
K
F
R
S
Y
C
F
V
A
Y
S
I
L
R
R
N
A
G
L
I
L
N
L
F
E
L
M
K
T
S
N
-----
I
P
D
I
R
I
D
P
N
G
A
I
L
R
V
R
E
R
F
N
L
N
M
S
E
E
D
A
T
V
H
F
Q
N
L
I
N
D
S
V
-
N
-
A
L
L
P
I
V
I
D
H
L
H
N
L
A
Q
Y
W
R
T
---------------------
30
HHSearch
70.55
35%
-26
- C3 -
-
4UWH
1
PK3C3_HUMAN
A:
[7-595]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
K
P
-------
N
A
---
A
T
R
D
Q
L
N
I
I
V
-
S
Y
P
P
T
K
-------
Q
L
----------------
T
Y
E
E
Q
D
L
V
W
K
F
R
Y
Y
L
T
N
-
Q
E
K
A
L
T
K
F
L
K
C
V
N
W
D
L
--
P
Q
E
A
K
Q
A
L
E
L
L
G
K
W
K
P
-
M
D
V
E
D
S
L
E
L
L
S
S
H
Y
T
---
N
--
P
T
V
R
R
Y
A
V
A
R
L
R
Q
-
A
-
D
D
-
E
D
L
L
M
Y
L
L
Q
L
V
Q
A
L
K
Y
--
E
N
-
F
------------------
D
D
I
K
N
G
LEPINSAEIDSSQIITSPLPNLE
Q
-
D
L
C
T
F
L
I
S
R
A
C
K
N
S
T
L
A
N
Y
L
Y
W
Y
V
I
V
E
C
E
D
Q
D
T
----
Q
Q
--------
R
D
P
--
K
T
H
E
M
Y
L
N
V
M
R
R
F
S
Q
A
L
L
K
GD
K
S
---
V
R
V
M
R
S
L
L
A
A
Q
Q
T
F
V
D
R
L
V
H
L
M
K
A
V
Q
R
E
S
G
N
R
K
K
K
N
E
R
L
Q
A
L
L
G
D
N
----------------------------------------------------------------------------------
E
--------------------------------
K
M
N
L
S
D
-
V
E
L
I
P
L
P
L
E
P
-
Q
V
K
I
R
G
I
I
P
--
E
T
A
T
L
F
K
S
-
A
L
M
P
A
Q
L
F
F
K
T
E
--------------------------------------------------------------------------
D
G
G
K
--
Y
P
V
I
F
K
H
G
D
D
L
R
Q
D
Q
L
I
L
Q
I
I
S
L
M
D
K
L
L
R
K
E
N
L
D
L
K
L
T
P
Y
K
V
L
A
T
S
T
K
H
G
F
M
Q
F
I
Q
--
S
-------
V
P
V
A
E
V
L
D
T
E---
G
-----
S
------------
I
Q
N
F
F
R
K
Y
----
A
P
--
S
ENGP
N
G
----
I
----
S
A
E
V
M
D
T
Y
V
K
S
C
A
G
Y
C
V
I
T
Y
I
L
G
V
G
D
R
H
L
D
N
L
L
L
T
K
-
T
G
K
L
F
H
I
D
F
G
----
Y
I
L
G
R
D
P
K
P
-----
L
P
P
P
M
K
L
-
N
K
E
M
V
E
G
M
G
G
---
T
-----
Q
S
E
Q
Y
-
Q
E
F
R
K
Q
C
Y
T
A
F
L
H
L
R
R
Y
S
N
L
I
L
N
L
F
S
L
M
V
D
A
-
N
I
P
D
-
I
A
L
E
---
P
D
K
T
V
K
K
V
Q
D
K
F
R
L
D
L
S
D
E
E
A
V
H
Y
M
Q
S
L
I
D
E
S
V
-
H
-
A
L
F
A
A
-----------------------------------
22
HHSearch
69.92
28%
-8
- C3 -
-
5DFZ
-
VPS34_YEAST
C:
[18-875]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
V
K
I
K
S
L
E
G
H
K
P
L
L
K
P
---
S
Q
K
I
LNPELMLIGS
N
V
F
P
S
S
D
L
I
V
S
L
Q
V
F
DK
E
----
R
N
R
N
L
T
L
P
I
Y
T
P
Y
I
P
F
R
N
S
-----------------------
R
-
T
W
D
Y
W
L
T
L
P
I
R
I
K
-------
Q
L
T
F
S
S
H
L
R
I
I
L
W
E
----------
Y
NGSK-----
Q
I
P
F
F
N
-----
L
E
T
S
--
I
F
N
L
K
D
C
T
L
--
K
--------
R
G
F
---------
E
S
L
K
F
R
Y
D
V
I
-
D
H
CEV
V
T
D
------
N
K
D
Q
E
N
L
N
K
Y
F
Q
G
E
F
T
R
L
---
P
W
L
D
E
I
T
I
S
K
L
R
K
Q
R
E
N
-
R
T
W
---------------
P
Q
G
T
F
V
L
---
N
L
E
F
P
M
L
E
-
L
P
V
V
-
F
I
E
R
E
I
M
NT----------------------------------------------
N
D
P
I
E
E
K
Y
R
R
L
E
R
A
S
K
N
A
N
L
-
D
K
Q
V
K
P
-------
D
I
---
K
K
R
D
Y
L
N
K
I
I
-
N
Y
P
P
G
T
-------
K
L
----------------
T
A
H
E
K
G
S
I
W
K
Y
R
Y
Y
L
M
N
-
N
K
K
A
L
T
K
L
L
Q
S
T
N
L
R
E
--
E
S
E
R
V
E
V
L
E
L
M
D
S
W
A
E
-
I
D
I
D
D
A
L
E
L
L
G
S
T
F
K
---
N
--
L
S
V
R
S
Y
A
V
N
R
L
K
K
-
A
-
S
D
-
K
E
L
E
L
Y
L
L
Q
L
V
E
A
V
C
F
--
E
N
-
L
STFSDKSNSEFTIVDAVS-------------------------------
P
L
A
E
F
L
I
R
R
A
L
V
N
P
R
L
G
S
F
F
Y
W
Y
L
K
S
E
S
E
D
K
------------------------
P
Y
L
D
Q
I
L
S
S
F
W
S
R
L
D
K
---------
K
S
R
N
I
L
N
D
Q
V
R
L
I
N
V
L
R
E
C
C
E
T
I
K
R
L
K
D
T
T
A
K
K
M
E
L
L
V
H
L
L
E
T
K
-------------------------------------------------------------------------------------------------------------------
V
R
P
L
V
K
-
V
R
P
I
A
L
P
L
D
P
-
D
V
L
I
C
D
V
C
P
--
E
T
S
K
V
F
K
S
-
S
L
S
P
L
K
I
T
F
K
T
T
--------------------------------------------------------------------------
L
N
Q
P
--
Y
H
L
M
F
K
V
G
D
D
L
R
Q
D
Q
L
V
V
Q
I
I
S
L
M
N
E
L
L
K
N
E
N
V
D
L
K
L
T
P
Y
K
I
L
A
T
G
P
Q
E
G
A
I
E
F
I
P
--
N
-------
D
T
L
A
S
I
L
SKY---
H
-----
G
------------
I
L
G
Y
L
K
L
H
----
Y
P
--
D
----
E
N
ATLG
V
----
Q
G
W
V
L
D
N
F
V
K
S
C
A
G
Y
C
V
I
T
Y
I
L
G
V
G
D
R
H
L
D
N
L
L
V
T
P
-
D
G
H
F
F
H
A
D
F
G
----
Y
I
L
G
Q
D
P
K
P
-----
F
P
P
L
M
K
L
-
P
P
Q
I
I
E
A
F
G
G
---
A
-----
E
S
S
N
Y
-
D
K
F
R
S
Y
C
F
V
A
Y
S
I
L
R
R
N
A
G
L
I
L
N
L
F
E
L
M
K
T
S
-
N
I
P
D
-
I
R
I
D
---
P
N
G
A
I
L
R
V
R
E
R
F
N
L
N
M
S
E
E
D
A
T
V
H
F
Q
N
L
I
N
D
S
V
-
N
-
A
L
L
P
I
V
I
D
H
L
H
N
L
A
Q
Y
W
R
T
---------------------
21
HHSearch
69.34
27%
-7
- C3 -
-
5KC2
-
VPS34_YEAST
C:
[17-875]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
K
V
K
I
K
S
L
E
G
H
K
P
L
L
K
P
---
S
Q
K
I
LNPELMLIGS
N
V
F
P
S
S
D
L
I
V
S
L
Q
V
F
DK
E
----
R
N
R
N
L
T
L
P
I
Y
T
P
Y
I
P
F
R
N
S
-----------------------
R
-
T
W
D
Y
W
L
T
L
P
I
R
I
K
-------
Q
L
T
F
S
S
H
L
R
I
I
L
W
E
----------
Y
NGSK-----
Q
I
P
F
F
N
-----
L
E
T
S
--
I
F
N
L
K
D
C
T
L
--
K
--------
R
G
F
---------
E
S
L
K
F
R
Y
D
V
I
-
D
H
CEV
V
T
D
------
N
K
D
Q
E
N
L
N
K
Y
F
Q
G
E
F
T
R
L
---
P
W
L
D
E
I
T
I
S
K
L
R
K
Q
R
E
N
-
R
T
W
---------------
P
Q
G
T
F
V
L
---
N
L
E
F
P
M
L
E
-
L
P
V
V
-
F
I
E
R
E
I
M
NT----------------------------------------------
N
D
P
I
E
E
K
Y
R
R
L
E
R
A
S
K
N
A
N
L
-
D
K
Q
V
K
P
-------
D
I
---
K
K
R
D
Y
L
N
K
I
I
-
N
Y
P
P
G
T
-------
K
L
----------------
T
A
H
E
K
G
S
I
W
K
Y
R
Y
Y
L
M
N
-
N
K
K
A
L
T
K
L
L
Q
S
T
N
L
R
E
--
E
S
E
R
V
E
V
L
E
L
M
D
S
W
A
E
-
I
D
I
D
D
A
L
E
L
L
G
S
T
F
K
---
N
--
L
S
V
R
S
Y
A
V
N
R
L
K
K
-
A
-
S
D
-
K
E
L
E
L
Y
L
L
Q
L
V
E
A
V
C
F
--
E
N
-
L
STFSDKSNSEFTIVDAVS-------------------------------
P
L
A
E
F
L
I
R
R
A
L
V
N
P
R
L
G
S
F
F
Y
W
Y
L
K
S
E
S
E
D
K
------------------------
P
Y
L
D
Q
I
L
S
S
F
W
S
R
L
D
K
---------
K
S
R
N
I
L
N
D
Q
V
R
L
I
N
V
L
R
E
C
C
E
T
I
K
R
L
K
D
T
T
A
K
K
M
E
L
L
V
H
L
L
E
T
K
-------------------------------------------------------------------------------------------------------------------
V
R
P
L
V
K
-
V
R
P
I
A
L
P
L
D
P
-
D
V
L
I
C
D
V
C
P
--
E
T
S
K
V
F
K
S
-
S
L
S
P
L
K
I
T
F
K
T
T
--------------------------------------------------------------------------
L
N
Q
P
--
Y
H
L
M
F
K
V
G
D
D
L
R
Q
D
Q
L
V
V
Q
I
I
S
L
M
N
E
L
L
K
N
E
N
V
D
L
K
L
T
P
Y
K
I
L
A
T
G
P
Q
E
G
A
I
E
F
I
P
--
N
-------
D
T
L
A
S
I
L
SKY---
H
-----
G
------------
I
L
G
Y
L
K
L
H
----
Y
P
--
D
----
E
N
ATLG
V
----
Q
G
W
V
L
D
N
F
V
K
S
C
A
G
Y
C
V
I
T
Y
I
L
G
V
G
D
R
H
L
D
N
L
L
V
T
P
-
D
G
H
F
F
H
A
D
F
G
----
Y
I
L
G
Q
D
P
K
P
-----
F
P
P
L
M
K
L
-
P
P
Q
I
I
E
A
F
G
G
---
A
-----
E
S
S
N
Y
-
D
K
F
R
S
Y
C
F
V
A
Y
S
I
L
R
R
N
A
G
L
I
L
N
L
F
E
L
M
K
T
S
-
N
I
P
D
-
I
R
I
D
---
P
N
G
A
I
L
R
V
R
E
R
F
N
L
N
M
S
E
E
D
A
T
V
H
F
Q
N
L
I
N
D
S
V
-
N
-
A
L
L
P
I
V
I
D
H
L
H
N
L
A
Q
Y
W
R
T
---------------------
27
HHSearch
68.44
27%
-31
- C3 -
-
5VLR
1
PK3CD_HUMAN
A:
[321-1012]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
M
K
L
V
V
Q
A
G
L
F
--
H
----
G
N
E
M
L
C
K
T
V
S
S
S
E
V
S
V
C
S
-----------------------
E
P
-
V
W
K
Q
R
L
E
F
D
I
N
I
C
-------
D
L
P
R
M
A
R
L
C
F
A
L
Y
A
----------
V
IEKAK
A
---
D
C
P
I
A
W
-----
A
N
L
M
--
L
F
D
Y
-
K
D
Q
L
--
K
--------
T
G
E
---------
R
C
L
Y
M
W
P
S
V
P
D
E
K
------------------------
G
--------
E
L
L
N
P
T
G
T
-----
V
----
R
S
N
-------------
P
N
T
D
S
A
A
A
L
---
L
I
C
L
P
E
V
A
P
H
P
V
Y
-
Y
P
A
L
E
---------------------------------------------------
K
I
L
E
-----
L
G
R
H
--------------------
T
E
---
E
E
Q
L
Q
L
R
E
I
L
-
E
----
G
-------
E
L
----------------
Y
E
H
E
K
D
L
V
W
K
L
R
H
E
V
Q
E
H
F
P
E
A
L
A
R
L
L
L
V
T
K
W
N
K
--
H
E
D
V
A
Q
M
L
Y
L
L
C
S
W
P
E
-
L
P
V
L
S
A
L
E
L
L
D
F
S
F
P
---
D
--
C
H
V
G
S
F
A
I
K
S
L
R
K
-
L
-
T
D
-
D
E
L
F
Q
Y
L
L
Q
L
V
Q
V
L
K
Y
--
E
S
-
Y
------------------
L
D---------------------------
C
-
E
L
T
K
F
L
L
D
R
A
L
A
N
R
K
I
G
H
F
L
F
W
H
L
R
S
E
M
H
V
P
S
V
---------------------
A
L
R
F
G
L
I
L
E
A
Y
C
R
G
S
T
H
----------
H
M
K
V
L
M
K
Q
G
E
A
L
S
K
L
K
A
L
N
D
F
V
K
L
S
S
Q
K
T
P
K
P
--
Q
T
K
E
L
M
H
L
---------------------------------------------------------------------------------
C
M
R
Q
-------------------------------
E
A
Y
L
E
A
-
L
S
H
L
Q
S
P
L
D
P
-
S
T
L
L
A
E
V
C
V
--
E
Q
C
T
F
M
D
S
-
K
M
K
P
L
W
I
M
Y
S
N
E
--
E
A
-------------------------------------------------------------------------
S
--
V
G
I
I
F
K
N
G
D
D
L
R
Q
D
M
L
T
L
Q
M
I
Q
L
M
D
V
L
W
K
Q
E
G
L
D
L
R
M
T
P
Y
G
C
L
P
T
G
D
R
T
G
L
I
E
V
V
L
--
R
S
------
D
T
I
A
N
I
Q
L
NFNK-
D
-----
A
------------
L
L
N
W
L
K
S
K
----
N
P
--
G
-----
E
----
A
----
L
D
R
A
I
E
E
F
T
L
S
C
A
G
Y
C
V
A
T
Y
V
L
G
I
G
D
R
H
S
D
N
I
M
I
R
E
-
S
G
Q
L
F
H
I
D
F
G
----
H
F
L
G
N
F
---INR--
E
R
V
P
F
I
L
-
T
Y
D
F
V
H
V
I
Q
Q
GKT
N
-----
N
S
E
K
F
-
E
R
F
R
G
Y
C
E
R
A
Y
T
I
L
R
R
H
G
L
L
F
L
H
L
F
A
L
M
R
A
A
-
G
L
P
E
-
L
S
C
S
-----
K
D
I
Q
Y
L
K
D
S
L
A
L
G
K
T
E
E
E
A
L
K
H
F
R
V
K
F
N
E
A
L
-
R
E
S
W
K
-------------------------------------
59
Fugue
67.78
23%
-10
- C3 -
-
4TUU
-
PK3CA_HUMAN
A:
[107-1046]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N
R
E
E
K
I
L
N
R
E
I
G
F
A
I
G
M
P
V
C
E
F
D
M
V
K
D
P
E
-
V
Q
D
F
R
R
N
I
L
N
V
C
K
E
A
V
D
L
R
--
D
L
N
S
P
H
S
R
A
M
Y
V
Y
P
P
N
V
E
S
S
P
E
LP
K
H
I
Y
----------
N
K
L
D
K
G
Q
I
I
V
V
I
W
V
I
--
V
SPNN
D
K
Q
K
Y
T
L
K
I
N
H
D
C
V
P
E
Q
V
I
A
E
A
I
R
K
K
T
R
S
M
L
Y
Q
G
K
Y
I
L
-
K
V
C
G
C
--
D
E
Y
F
L
E
K
Y
P
L
S
QY
K
Y
I
R
S
C
I
M
L
G
R
M
P
N
L
M
L
M
A
----------
K
---------
E
S
L
Y
S
Q
-----
L
P
M
D
--
C
F
T
M
-
P
S
Y
S
--
R
KSLWVIN
S
A
L
R
---------
I
K
I
L
C
A
T
Y
V
N
V
N
D
---
K
I
Y
V
R
T
-
G
I
Y
H
G
G
E
P
L
C
D
N
V
N
T
Q
R
V
P
C
S
N
P
R
W
N
E
W
L
N
Y
D
I
Y
I
P
D
L
P
R
-
A
A
R
L
C
L
S
I
C
S
V
K
E
E
H
C
P
L
A
W
G
N
I
N
L
FDY
T
D
T
L
V
S
G
K
-
M
-
A
L
-
N
L
W
P
V
P
H
--
G
L
E
D
L
L
N
P
I
G
V
T
G
S
N
-
P
N
K
E
T
P
C
L
E
L
E
F
D
W
F
S
S
V
V
K
F
P
D
M
S
V
I
E
E
H
A
N
W
S
V
S
R
E
A
G
F
S
Y
S
-
H
A
G
L
S
-
N
R
L
A
R
D
-------
N
E
LR
E
N
D
K
E
Q
L
K
A
I
S
-
T
R
D
P
L
S
E
I
T
-----------------------
E
Q
E
K
D
F
L
W
S
H
R
H
Y
C
V
T
-
I
P
E
I
L
P
K
L
L
L
S
V
K
W
N
S
--
R
D
E
V
A
Q
M
Y
C
L
V
K
D
W
P
P
-
I
K
P
E
Q
A
M
E
L
L
D
C
N
Y
P
--
D
---
P
M
V
R
G
F
A
V
R
C
L
E
K
-
Y
L
T
D
-
D
K
L
S
Q
Y
L
I
Q
L
V
Q
V
L
K
Y
--
E
Q
Y
L
------------------
D
----------------------------
N
-
L
L
V
R
F
L
L
K
K
A
L
T
N
Q
R
I
G
H
F
F
F
W
H
L
K
S
E
M
H
--------------
N
K
-
T
V
S
Q
R
F
G
--
L
L
L
E
S
Y
C
R
A
--------------
C
G
M
Y
L
K
H
L
N
R
Q
V
E
A
M
E
K
L
I
N
L
T
D
I
L
K
Q
E
K
K
D
E
--
T
Q
K
V
Q
M
K
F
L
V
E
Q
M
R
--
R
P
D
F
M
D
A
L
Q
G
F
L
S
--------------------------------------------------------------------
P
L
N
P
A
H
Q
L
G
N
L
R
L
E
E
----------------------------------------------
C
R
I
M
S
S
-
A
K
R
P
L
W
L
N
W
E
-------------------------
N
P
D
I
M
S
E
L
L
F
Q
---------------------------------------------
N
N
E
I
I
F
K
N
G
D
D
L
R
Q
D
M
L
T
L
Q
I
I
R
I
M
E
N
I
W
Q
N
Q
G
L
D
L
R
M
L
P
Y
G
C
L
S
I
G
D
C
V
G
L
I
E
V
V
R
--
N
S
------
H
T
I
M
Q
I
Q
C
KGFNS
H
-----
T
------------
L
H
Q
W
L
K
D
K
----
N
K
--
G
-----
E
----
I
----
Y
D
A
A
I
D
L
F
T
R
S
C
A
G
Y
C
V
A
T
F
I
L
G
I
G
D
R
H
N
S
N
I
M
V
K
D
-
D
G
Q
L
F
H
I
D
F
G
----
H
F
L
D
R
-----------
V
P
F
V
L
-
T
Q
D
F
L
I
V
I
S
----
T
-----
K
T
R
E
F
-
E
R
F
Q
E
M
C
Y
K
A
Y
L
A
I
R
Q
H
A
N
L
F
I
N
L
F
S
M
M
L
G
S
-
G
M
P
E
-
L
Q
-----
S
F
D
D
I
A
Y
I
R
K
T
L
A
L
D
K
T
E
Q
E
A
L
E
Y
F
M
K
Q
M
N
D
A
--------------------------------------------
29
HHSearch
67.19
35%
-18
- C3 -
-
2X6K
1
?
A:
[38-695]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
---
S
I
R
D
Q
L
H
T
I
V
Y
R
Y
P
P
T
Y
-------
V
L
----------------
S
S
E
E
Q
D
L
V
W
K
F
R
F
Y
L
S
S
-
H
K
K
A
L
T
K
F
L
K
C
I
N
W
K
L
--
E
D
E
V
T
Q
A
L
W
M
L
A
N
W
A
P
-
M
D
V
E
D
A
L
E
L
L
S
P
T
F
T
---
H
--
P
Q
V
R
K
Y
A
V
S
R
L
A
Q
-
A
-
P
D
-
E
D
L
L
L
Y
L
L
Q
L
V
Q
A
L
K
Y
--
E
D
-
P
------------------
R
H
I
V
H
L
H
G
C
I
FP-----------------
A
-
N
L
C
T
F
L
I
Q
R
A
C
T
N
A
T
L
A
N
Y
F
Y
W
Y
L
S
I
E
V
E
E
V
E
S
----
V
------
R
-
K
Q
D
E
--
R
A
H
D
M
Y
A
M
V
L
K
M
F
L
K
V
L
E
N
---
G
N
F
N
L
R
G
I
F
Y
N
L
R
K
Q
R
R
F
I
D
E
L
V
K
L
V
K
L
V
A
K
E
P
G
N
R
N
K
K
T
E
K
F
Q
K
L
L
A
E
Q
D
----------------------------------------------------------------------------------
M
------------------------------
F
K
V
N
F
T
N
-
F
E
P
I
P
F
P
L
D
P
-
E
I
Y
I
T
K
I
V
P
--
M
R
T
S
L
F
K
S
-
A
L
M
P
A
K
L
T
F
V
T
S
--
I
-----------------------------------------------------------------------
A
H
H
E
--
Y
A
A
I
F
K
H
G
D
D
L
R
Q
D
Q
L
I
L
Q
M
I
T
L
M
D
K
L
L
R
R
E
N
L
D
L
K
L
T
P
Y
K
V
L
A
T
S
S
K
H
G
F
L
Q
Y
V
D
--
S
-------
C
T
V
A
E
V
L
A
R
E---
G
-----
N
------------
I
H
N
F
F
R
K
H
----
H
P
--
C
----
D
N
----
G
PYGI
S
A
E
V
M
D
T
Y
I
K
S
C
A
G
Y
C
V
I
T
Y
L
L
G
V
G
D
R
H
L
D
N
L
L
L
T
T
-
N
G
K
L
F
H
I
D
F
G
----
Y
I
L
G
R
D
P
K
P
-----
M
P
P
P
M
K
L
-
S
K
E
M
V
E
A
M
G
G
---
I
-----
S
S
E
H
H
-
H
E
F
R
K
Q
C
Y
T
A
Y
L
H
L
R
R
H
A
N
V
M
L
N
L
F
S
L
M
V
D
A
-
T
V
P
D
-
I
A
L
E
---
P
D
K
A
V
K
K
V
E
E
N
L
Q
L
G
L
T
D
E
E
A
V
Q
H
L
Q
S
L
L
D
V
S
I
-
T
-
A
V
M
P
A
L
V
E
Q
I
H
R
F
T
Q
Y
W
R
----------------------
24
HHSearch
64.59
25%
-3
* C3 *
-
4JPS
1
PK3CA_HUMAN
A:
[350-1061]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
D
K
I
Y
V
R
T
G
I
Y
--
H
----
G
G
E
P
L
C
D
N
V
N
T
Q
R
V
P
C
S
N
------------------------
P
-
R
W
N
E
W
L
N
Y
D
I
Y
I
P
-------
D
L
P
R
A
A
R
L
C
L
S
I
C
S
----------
V
K
GRKGA
K
E
E
H
C
P
L
A
W
-----
G
N
I
N
--
L
F
D
Y
-
T
D
T
L
--
V
--------
S
G
K
---------
M
A
L
N
L
W
P
V
P
H
G
L
E
----------
D
L
--------------
L
N
P
I
---
G
V
--------------
T
-
G
S
N
-------------
P
-
N
K
E
T
P
C
L
---
E
L
E
F
D
W
F
S
-
S
V
V
K
-
F
P
D
M
S
V
I
--
E
E
H
A
----------------
N
---------------------------------------------------
E
------------
N
D
K
E
Q
L
K
A
I
S
-
T
R
D
P
L
S
-------
E
I
----------------
T
E
Q
E
K
D
F
L
W
S
H
R
H
Y
C
V
T
-
I
P
E
I
L
P
K
L
L
L
S
V
K
W
N
S
--
R
D
E
V
A
Q
M
Y
C
L
V
K
D
W
P
P
-
I
K
P
E
Q
A
M
E
L
L
D
C
N
Y
P
---
D
--
P
M
V
R
G
F
A
V
R
C
L
E
K
Y
L
-
T
D
-
D
K
L
S
Q
Y
L
I
Q
L
V
Q
V
L
K
Y
--
E
Q
-
Y
------------------
L
D---------------------------
N
-
L
L
V
R
F
L
L
K
K
A
L
T
N
Q
R
I
G
H
F
F
F
W
H
L
K
S
E
M
H
N
K
T
V
---------------------
S
Q
R
F
G
L
L
L
E
S
Y
C
R
A
C
G
M
----------
Y
L
K
H
L
N
R
Q
V
E
A
M
E
K
L
I
N
L
T
D
I
L
K
Q
E
K
K
D
E
T
Q
K
V
Q
-
M
K
F
L
V
----------------------------------------------------------------------------------
E
Q
M
R
R
P
---
D
--------------------------
F
M
D
A
---
L
Q
G
F
L
S
P
L
N
P
-
A
H
Q
L
G
N
L
R
L
--
E
E
C
R
I
M
S
S
-
A
K
R
P
L
W
L
N
W
E
N
P
--
D
I
M
S
------------------------------------------------------------------
E
L
L
F
Q
N
--
N
E
I
I
F
K
N
G
D
D
L
R
Q
D
M
L
T
L
Q
I
I
R
I
M
E
N
I
W
Q
N
Q
G
L
D
L
R
M
L
P
Y
G
C
L
S
I
G
D
C
V
G
L
I
E
V
V
R
--
N
S
------
H
T
I
M
Q
I
Q
C
KFNS-
H
-----
T
------------
L
H
Q
W
L
K
D
K
----
N
K
--
G
-----
E
----
I
----
Y
D
A
A
I
D
L
F
T
R
S
C
A
G
Y
C
V
A
T
F
I
L
G
I
G
D
R
H
N
S
N
I
M
V
K
D
-
D
G
Q
L
F
H
I
D
F
G
----
H
F
L
D
H
K
K
K
K
FG
Y
K
R
E
R
V
P
F
V
L
-
T
Q
D
F
L
I
V
I
S
K
---
G
AQECT
K
T
R
E
F
-
E
R
F
Q
E
M
C
Y
K
A
Y
L
A
I
R
Q
H
A
N
L
F
I
N
L
F
S
M
M
L
G
S
-
G
M
P
E
-
L
Q
S
F
-----
D
D
I
A
Y
I
R
K
T
L
A
L
D
K
T
E
Q
E
A
L
E
Y
F
M
K
Q
M
N
D
A
H
H
G
-
G
W
T
T
K
M
D
W
I
F
H
T
----------------------------
57
Fugue
62.11
19%
-53
- C3 -
-
1E8X
1
PK3CG_PIG
A:
[1-951]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
S
E
E
T
L
A
F
Q
R
Q
L
N
A
L
-
I
G
Y
D
V
T
D
V
S
N
-
V
H
D
D
E
L
E
F
T
R
R
R
L
V
T
P
R
M
A
--
E
V
A
G
R
D
P
K
L
Y
A
M
H
P
W
V
T
S
K
P
L
P
--
E
Y
L
L
----------
K
K
I
T
N
N
C
V
F
I
V
I
H
R
S
--
T
----
T
S
Q
T
I
K
V
S
A
D
D
T
P
G
T
I
L
Q
S
F
F
T
K
M
A
N
E
R
D
F
V
L
R
V
C
G
R
D
-
E
Y
L
---
V
G
E
T
P
I
K
N
F
Q
W
V
-------
R
Q
C
L
K
N
G
E
E
I
H
L
V
L
----------
D
---------
T
P
P
D
P
A
-----
L
D
E
V
--
R
K
E
C
-
D
R
K
F
--
R
--------
V
K
I
---------
R
G
I
D
I
P
V
------------
L
P
R
-
T
A
D
L
T
V
F
V
E
A
N
I
Q
Y
G
---
Q
Q
---
V
L
C
Q
R
R
T
S
P
K
P
F
T
E
E
V
L
-
W
N
V
W
L
E
F
S
I
K
I
K
D
L
P
K
G
A
L
L
N
L
Q
I
Y
---
C
Q
L
L
Y
Y
V
N
-
L
-
L
L
-
I
D
H
R
F
L
L
--
R
H
G
E
Y
V
L
H
M
W
Q
---
L
-
S
G
F
N
A
D
K
L
T
S
A
T
N
------
P
--------------
D
K
E
N
S
M
S
I
S
I
-
L
L
D
N
H
-
P
I
A
L
E
M
-------
P
N
---
Q
L
R
K
Q
L
E
A
I
I
-
A
T
D
P
L
N
-----------------------
P
L
T
A
E
D
K
E
L
L
W
H
F
R
Y
E
S
L
K
-
D
P
K
A
Y
P
K
L
F
S
S
V
K
W
G
Q
Q
E
I
V
A
K
T
Y
Q
L
L
A
K
R
E
V
W
D
-
Q
S
A
L
D
V
G
L
T
M
Q
L
L
D
C
--
N
F
SD
E
N
V
R
A
I
A
V
Q
K
L
E
S
-
L
-
E
D
-
D
D
V
L
H
Y
L
L
Q
L
V
Q
A
V
K
F
--
E
P
-
Y
------------------
H
----------------------------
D
S
A
L
A
R
F
L
L
K
R
G
L
R
N
K
R
I
G
H
F
L
F
W
F
L
R
S
E
I
A
Q
S
----------------
R
H
Y
Q
Q
R
F
A
V
I
L
E
A
Y
L
R
G
C
G
-------------
T
A
M
L
H
D
F
T
Q
Q
V
Q
V
I
D
M
L
Q
K
V
T
I
D
I
K
S
L
-----------------------------------------------------------------------------------------------------------------
S
A
E
K
Y
D
V
S
S
Q
V
I
S
Q
L
K
Q
K
L
E
N
L
Q
N
L
N
L
P
Q
S
F
R
V
P
Y
D
P
-
G
L
K
A
G
A
L
V
I
--
E
K
C
K
V
M
A
S
-
K
K
K
P
L
W
L
E
F
K
C
A
--
D
P
T
A
---------------------------------------------------------------------
L
S
N
E
T
I
G
I
I
F
K
H
G
D
D
L
R
Q
D
M
L
I
L
Q
I
L
R
I
M
E
S
I
W
E
T
E
S
L
D
L
C
L
L
P
Y
G
C
I
S
T
G
D
K
I
G
M
I
E
I
V
K
--
D
A
------
T
T
I
A
K
I
Q
------
Q
-----
S
T
VGNTGAFKDE
V
L
S
H
W
L
K
E
K
----
C
P
--
I
----
E
E
----
K
----
F
Q
A
A
V
E
R
F
V
Y
S
C
A
G
Y
C
V
A
T
F
V
L
G
I
G
D
R
H
N
D
N
I
M
I
S
E
-
T
G
N
L
F
H
I
D
F
G
----
H
V
---------------
P
F
V
L
-
T
P
D
F
L
F
V
M
G
T
SGK
K
-----
T
S
L
H
F
-
Q
K
F
Q
D
V
C
V
K
A
Y
L
A
L
R
H
H
T
N
L
L
I
I
L
F
S
M
M
L
M
T
G
-
M
P
Q
-
L
T
S
K
E
-----
D
I
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Y
I
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D
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K
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D
A
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K
Y
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C
R
-
D
-
K
G
W
T
V
Q
F
N
W
F
L
H
L
V
L
-------------------------
61
Fugue
52.47
16%
11
- C3 -
-
4JSP
1
MTOR_HUMAN
A:
[10-1174]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
A
A
K
C
R
A
Y
A
K
A
L
H
Y
K
E
L
E
F
Q
K
G
P
T
P
A
I
L
E
S
L
I
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I
N
N
K
L
Q
Q
P
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A
A
A
G
V
L
E
Y
A
M
K
H
F
G
E
L
--
E
I
Q
A
----------
T
W
Y
E
K
L
H
-
E
W
E
D
A
L
V
--
A
----
Y
D
K
K
M
D
T
N
K
D
D
P
E
L
M
L
G
R
M
R
C
L
E
A
L
---
G
E
W
G
Q
L
H
Q
Q
C
-
C
E
K
W
T
L
V
N
D
--
E
T
Q
A
K
M
A
-------
R
M
A
A
A
A
A
W
G
L
G
Q
W
D
S
M
E
E
Y
T
C
M
IP
R
---------
D
T
H
D
G
A
F
Y
R
A
V
L
A
L
H
Q
D
L
F
S
L
-
A
Q
Q
C
--
I
--------
D
K
A
---------
R
D
L
L
D
A
E
L
T
A
M
A
G
---
E
S
Y
S
R
A
Y
G
A
M
V
S
C
H
M
L
S
E
L
E
E
V
I
Q
Y
K
L
---
V
P
E
R
R
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I
I
R
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I
W
W
E
R
L
Q
G
C
Q
R
I
V
E
D
W
Q
K
I
L
M
V
R
S
L
V
V
S
P
H
E
D
M
---
R
T
W
L
K
Y
A
S
-
L
-
C
G
-
K
-
S
G
R
L
A
--
L
A
H
K
T
L
V
L
L
L
G
---
V
-
D
P
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R
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L
D
H
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L
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------
H
P
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M
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N
M
W
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A
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Q
Q
A
QHAIATE
D
Q
---
Q
H
K
Q
E
L
H
K
L
M
-
A
R
C
F
L
K
L
G
E
W
Q
L
N
L
Q
GINES
T
I
P
K
V
L
Q
Y
Y
S
A
A
T
E
H
D
R
S
W
Y
K
A
W
H
A
W
A
V
M
N
F
E
A
V
L
H
Y
K
H
Q
N
Q
A
R
D
E
K
K
K
V
T
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D
L
S
K
T
L
L
M
Y
T
V
-
P
A
V
Q
G
F
F
R
S
I
S
L
S
R
G
--
N
N
-----
L
Q
D
T
L
R
V
L
T
L
-
W
-
F
D
Y
G
H
W
P
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A
L
V
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G
V
K
A
IQ
I
D
-
T
------------------
W
----------------------------
L
-
Q
V
I
P
Q
L
I
A
R
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R
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L
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R
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L
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Y
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I
Y
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A
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K
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T
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A
A
N
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L
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C
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H
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N
T
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V
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---
Q
---
A
M
M
V
S
E
E
L
I
R
V
A
-------
I
L
W
H
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M
W
H
E
G
L
E
E
A
S
R
L
Y
F
G
E
R
----
N
V
K
G
M
F
E
V
L
E
P
L
H
A
M
M
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R
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P
Q
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F
N
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A
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G
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L
M
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A
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W
C
R
K
Y
M
K
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N
V
K
D
L
T
Q
A
----
W
D
L
Y
Y
H
V
F
R
R
I
S
K
Q
L
P
Q
L
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L
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L
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Y
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S
P
K
L
L
M
C
R
D
L
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L
A
------------------
V
P
G
T
Y
D
-------
P
-
N
Q
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P
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-
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H
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F
V
F
L
L
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G
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L
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D
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M
Q
L
F
G
L
V
N
T
L
L
A
N
D
P
T
S
L
R
K
N
L
S
I
Q
R
Y
---------
A
V
--
I
P
L
S
T
N
S
G
L
I
G
W
V
P
H
C
D
T
--------------------
L
H
A
L
I
R
D
Y
R
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K
K
K
I
L
L
N
I
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H
R
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L
R
M
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D
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D
H
L
T
L
M
Q
--
K
V
------
E
V
F
E
H
A
V
------
N
N
T
AGD
D
------------
L
A
K
L
L
W
L
K
----
S
P
--
S
----
S
E
----
V
----
W
F
D
R
R
T
N
Y
T
R
S
L
A
V
M
S
M
V
G
Y
I
L
G
L
G
D
R
H
P
S
N
L
M
L
D
R
L
S
G
K
I
L
H
I
D
F
G
DCFE
V
A
M
T
R
E
K
F
P
-----
E
K
I
P
F
R
L
-
T
R
M
L
T
N
A
M
E
V
---
T
-----
G
L
D
G
---
N
Y
R
I
T
C
H
T
V
M
E
V
L
R
E
H
K
D
S
V
M
A
V
L
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A
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V
Y
D
P
L
L
N
W
R
L
M
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T
N
T
A
L
N
K
K
A
I
Q
I
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N
R
V
R
D
K
L
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G
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F
S
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D
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D
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P
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-
E
-
L
L
I
K
Q
A
T
S
-
H
E
N
L
C
Q
C
Y
I
G
WCPFW----------------
33
HHSearch
49.80
18%
-25
- C3 -
-
5C46
1
PI4KB_HUMAN
E:
[19-527]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
K
L
-
F
D
I
S
M
A
I
S
Y
L
-
Y
N
S
K
---
E
--
P
G
V
Q
A
Y
I
G
N
R
L
F
C
-
F
-
R
N
-
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D
V
D
F
Y
L
P
Q
L
L
N
M
Y
I
H
--
M
D
-
E
DV----------------
G
----------------------------
D
-
A
I
K
P
Y
I
V
H
R
C
R
Q
S
I
N
F
S
L
Q
C
A
L
L
L
G
A
Y
S
-----------------------
S
R
G
T
K
L
R
K
L
I
L
S
D
--------------------
R
L
A
P
E
R
E
F
I
K
S
L
M
A
I
G
K
R
L
A
T
L
P
T
K
-
E
Q
K
T
Q
R
L
I
S
E
L
S
L
L
----------------------------------------------------------------------------------
N
---------------------------------
H
K
L
---
P
A
R
V
W
L
P
T
A
G
F
D
H
H
V
V
R
V
P
H
--
T
Q
A
V
V
L
N
S
K
D
K
A
P
Y
L
I
Y
V
E
V
L
--
E
C
E
N
F
D
T
T
S
-----------------
V
P
A
R
I
P
------------
D
P
S
A
V
A
L
K
E
P
W
Q
E
KV
R
R
I
R
E
G
S
P
Y
G
H
L
P
N
W
R
L
--
L
S
V
I
V
K
C
G
D
D
L
R
Q
E
L
L
A
F
Q
V
L
K
Q
L
Q
S
I
W
E
Q
E
R
V
P
L
W
I
K
P
Y
K
I
L
V
I
S
A
D
S
G
M
I
E
P
V
V
--
N
A
------
V
S
I
H
Q
V
K
KQSQ--
L
-----
S
------------
L
L
D
Y
F
L
Q
E
----
H
G
SY
T
----
T
E
----
A
----
F
L
S
A
Q
R
N
F
V
Q
S
C
A
G
Y
C
L
V
C
Y
L
L
Q
V
K
D
R
H
N
G
N
I
L
L
D
A
-
E
G
H
I
I
H
I
D
F
G
----
F
I
L
S
S
S
P
---------
S
A
F
K
L
-
T
T
E
F
V
D
V
M
G
G
---
L
-----
D
G
D
M
F
-
N
Y
Y
K
M
L
M
L
Q
G
L
I
A
A
R
K
H
M
D
K
V
V
Q
I
V
E
I
M
Q
Q
G
S
Q
L
P
C
-
F
H
G
S
-----
S
T
I
R
N
L
K
E
R
F
H
M
S
M
T
E
E
Q
L
Q
L
L
V
E
Q
M
V
D
G
S
M
-------------------------------------------
15
PsiBlast_PDB
49.70
42%
-17
- C3 -
-
2X6H
-
?
A:
[694-948]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
I
F
K
H
G
D
D
L
R
Q
D
Q
L
I
L
Q
M
I
T
L
M
D
K
L
L
R
R
E
N
L
D
L
K
L
T
P
Y
K
V
L
A
T
S
S
K
H
G
F
L
Q
Y
V
D
--
S
C
------
T
V
A
E
V
L
A
------
R
E
G---
N
------------
I
H
N
F
F
R
K
H
HPCD
N
G
--
P
----
Y
G
----
I
----
S
A
E
V
M
D
T
Y
I
K
S
C
A
G
Y
C
V
I
T
Y
L
L
G
V
G
D
R
H
L
D
N
L
L
L
T
T
-
N
G
K
L
F
H
I
D
F
G
----
Y
I
L
G
R
D
P
K
P
-----
M
P
P
P
M
K
L
-
S
K
E
M
V
E
A
M
G
G
---
I
-----
S
S
E
H
H
-
H
E
F
R
K
Q
C
Y
T
A
Y
L
H
L
R
R
H
A
N
V
M
L
N
L
F
S
L
M
V
D
A
-
T
V
P
D
-
I
A
L
E
---
P
D
K
A
V
K
K
V
E
E
N
L
Q
L
G
L
T
D
E
E
A
V
Q
H
L
Q
S
L
L
D
V
S
I
-
T
-
A
V
M
P
A
L
V
E
Q
I
H
R
F
T
Q
Y
W
R
----------------------
14
PsiBlast_PDB
49.34
42%
-20
- C3 -
-
2X6F
1
?
A:
[441-695]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
I
F
K
H
G
D
D
L
R
Q
D
Q
L
I
L
Q
M
I
T
L
M
D
K
L
L
R
R
E
N
L
D
L
K
L
T
P
Y
K
V
L
A
T
S
S
K
H
G
F
L
Q
Y
V
D
--
S
C
------
T
V
A
E
V
L
A
------
R
EG---
N
------------
I
H
N
F
F
R
K
H
HPCD
N
G
--
P
----
Y
G
----
I
----
S
A
E
V
M
D
T
Y
I
K
S
C
A
G
Y
C
V
I
T
Y
L
L
G
V
G
D
R
H
L
D
N
L
L
L
T
T
-
N
G
K
L
F
H
I
D
F
G
----
Y
I
L
G
R
D
P
K
P
-----
M
P
P
P
M
K
L
-
S
K
E
M
V
E
A
M
G
G
---
I
-----
S
S
E
H
H
-
H
E
F
R
K
Q
C
Y
T
A
Y
L
H
L
R
R
H
A
N
V
M
L
N
L
F
S
L
M
V
D
A
-
T
V
P
D
-
I
A
L
E
---
P
D
K
A
V
K
K
V
E
E
N
L
Q
L
G
L
T
D
E
E
A
V
Q
H
L
Q
S
L
L
D
V
S
I
-
T
-
A
V
M
P
A
L
V
E
Q
I
H
R
F
T
Q
Y
W
R
----------------------
6
PsiBlast_PDB
49.04
42%
-20
- C3 -
-
3IHY
-
PK3C3_HUMAN
A:
[619-871]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
L
F
F
K
T
E
D
G
G
K
Y
P
V
--
I
F
K
H
G
D
D
L
R
Q
D
Q
L
I
L
Q
I
I
S
L
M
D
K
L
L
R
K
E
N
L
D
L
K
L
T
P
Y
K
V
L
A
T
S
T
K
H
G
F
M
Q
F
I
Q
--
S
V
P
V
A
E
V
L
D
T
E
G
S
I
Q
------
N
-----
F
------------
F
R
K
Y
A
P
S
E
----
N
G
--
P
----
N
G
----
I
----
S
A
E
V
M
D
T
Y
V
K
S
C
A
G
Y
C
V
I
T
Y
I
L
G
V
G
D
R
H
L
D
N
L
L
L
T
K
-
T
G
K
L
F
H
I
D
F
G
----
Y
I
L
G
R
D
P
K
P
-----
L
P
P
P
M
K
L
-
N
K
E
M
V
E
G
M
G
G
---
T
-----
Q
S
E
Q
Y
-
Q
E
F
R
K
Q
C
Y
T
A
F
L
H
L
R
R
Y
S
N
L
I
L
N
L
F
S
L
M
V
D
A
-
N
I
P
D
-
I
A
L
E
---
P
D
K
T
V
K
K
V
Q
D
K
F
R
L
D
L
S
D
E
E
A
V
H
Y
M
Q
S
L
I
D
E
S
V
-
H
-
A
L
F
-------------------------------------
18
PsiBlast_PDB
48.93
42%
-18
- C3 -
-
2X6K
1
?
A:
[441-695]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
I
F
K
H
G
D
D
L
R
Q
D
Q
L
I
L
Q
M
I
T
L
M
D
K
L
L
R
R
E
N
L
D
L
K
L
T
P
Y
K
V
L
A
T
S
S
K
H
G
F
L
Q
Y
V
D
--
S
C
------
T
V
A
E
V
L
A
------
R
EG---
N
------------
I
H
N
F
F
R
K
H
HPCD
N
G
--
P
----
Y
G
----
I
----
S
A
E
V
M
D
T
Y
I
K
S
C
A
G
Y
C
V
I
T
Y
L
L
G
V
G
D
R
H
L
D
N
L
L
L
T
T
-
N
G
K
L
F
H
I
D
F
G
----
Y
I
L
G
R
D
P
K
P
-----
M
P
P
P
M
K
L
-
S
K
E
M
V
E
A
M
G
G
---
I
-----
S
S
E
H
H
-
H
E
F
R
K
Q
C
Y
T
A
Y
L
H
L
R
R
H
A
N
V
M
L
N
L
F
S
L
M
V
D
A
-
T
V
P
D
-
I
A
L
E
---
P
D
K
A
V
K
K
V
E
E
N
L
Q
L
G
L
T
D
E
E
A
V
Q
H
L
Q
S
L
L
D
V
S
I
-
T
-
A
V
M
P
A
L
V
E
Q
I
H
R
F
T
Q
Y
W
R
----------------------
16
PsiBlast_PDB
48.91
42%
-14
- C3 -
-
2X6I
1
?
A:
[441-695]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
I
F
K
H
G
D
D
L
R
Q
D
Q
L
I
L
Q
M
I
T
L
M
D
K
L
L
R
R
E
N
L
D
L
K
L
T
P
Y
K
V
L
A
T
S
S
K
H
G
F
L
Q
Y
V
D
--
S
C
------
T
V
A
E
V
L
A
------
R
EG---
N
------------
I
H
N
F
F
R
K
H
HPCD
N
G
--
P
----
Y
G
----
I
----
S
A
E
V
M
D
T
Y
I
K
S
C
A
G
Y
C
V
I
T
Y
L
L
G
V
G
D
R
H
L
D
N
L
L
L
T
T
-
N
G
K
L
F
H
I
D
F
G
----
Y
I
L
G
R
D
P
K
P
-----
M
P
P
P
M
K
L
-
S
K
E
M
V
E
A
M
G
G
---
I
-----
S
S
E
H
H
-
H
E
F
R
K
Q
C
Y
T
A
Y
L
H
L
R
R
H
A
N
V
M
L
N
L
F
S
L
M
V
D
A
-
T
V
P
D
-
I
A
L
E
---
P
D
K
A
V
K
K
V
E
E
N
L
Q
L
G
L
T
D
E
E
A
V
Q
H
L
Q
S
L
L
D
V
S
I
-
T
-
A
V
M
P
A
L
V
E
Q
I
H
R
F
T
Q
Y
W
R
----------------------
63
Fugue
48.33
15%
-0
- C3 -
-
5H64
-
MTOR_HUMAN
A:
[210-2549]
V
A
A
L
R
A
C
L
ILTTQREPKEM
Q
K
P
Q
W
Y
R
H
T
F
E
E
A
E
K
GFDE
T
L
A
K
E
K
GMNRDDRIHGALLIL
N
E
L
V
R
I
S
S
MEGERLR
E
E
M
E
E
I
T
Q
QQLVHDKYCKDLMGF
G
T
K
P
R
H
I
T
P
FTS
F
Q
A
V
Q
P
QQSNALVGLLGY
S
S
H
Q
G
L
M
G
F
G
TSPSPAKSTLVES
R
C
C
R
D
L
M
EEKFDQVCQWVLKCRN
S
K
N
S
L
I
QMTILN
L
L
P
R
L
A
AFRPSAFTD
T
Q
Y
L
Q
D
T
M
N
H
V
L
S
CVKV
L
Y
D
L
S
R
Q
I
PQLKKDIQDG
L
L
K
M
L
S
L
V
L
M
H
K
P
L
R
H
P
GMPKGLA
H
Q
L
A
S
PGLTTLPEASDVG
S
I
T
L
A
L
R
T
LGSFE
F
E
G
H
S
L
T
Q
F
VRHCADH
F
L
N
S
E
H
KEIRM
E
A
A
R
T
C
SRLLTPSIHLISGHAHVVSQT
A
V
Q
V
V
A
D
V
LSKLLVVGITDPDP
D
I
R
Y
C
V
L
ASLDERFDAH
L
A
Q
A
E
N
L
Q
A
L
FVALN
D
Q
V
F
E
I
R
E
L
AICTVGRLS
S
M
N
P
A
F
V
M
P
F
L
R
K
MLI
Q
I
L
T
E
L
E
H
S
GIGRIKEQSARML
G
H
L
V
S
N
A
P
R
L
I
R
PYMEPILK
A
L
I
L
K
L
K
D
P
D
PDPNPGV
I
N
N
V
L
A
TI
G
E
L
A
Q
V
S
G
L
E
MRKWVDELF
I
I
I
M
D
M
L
Q
D
S
S
L
L
A
K
RQVALWTL
G
Q
L
V
A
S
T
G
Y
V
V
E
PYRKYPTLL
E
V
L
L
N
F
L
K
T
EQNQG
T
R
R
E
A
IR
V
L
G
L
L
G
A
L
D
PYKHK
V
N
I
G
M
I
D
Q
S
R
D
A
S
A
VSLSESKSSQDSSM
L
V
N
M
G
NLPLDEFY
P
A
V
S
M
V
A
L
M
R
I
F
R
D
Q
S
L
S
H
HHTMVV
Q
A
I
T
F
I
F
K
S
L
G
L
K
C
VQFLP
Q
V
M
P
T
F
L
N
V
I
R
V
C
D
G
AIR
E
F
L
F
Q
Q
L
G
M
L
V
S
F
V
K
S
HIR
P
Y
M
D
E
IV
T
L
M
R
E
F
W
V
M
N
TSIQ
S
T
I
I
L
L
I
E
Q
I
V
V
A
L
G
G
E
FKLYLPQLIPHM
L
R
V
F
M
H
DNSPGRIV
S
I
K
L
L
A
A
I
Q
L
F
G
A
NLDDYLHLLL
P
P
I
V
K
L
F
D
APEA
P
L
P
S
R
K
A
A
L
E
T
V
D
R
L
T
E
SLDFTDYA
S
R
I
I
H
P
I
V
R
T
L
D
QSPEL
R
S
T
A
M
D
T
L
S
S
L
V
F
QLG
K
K
Y
Q
I
F
I
P
M
V
N
K
V
L
VRHRINHQ
R
Y
D
V
L
I
C
R
I
V
K
G
Y
T
LM
K
K
L
H
V
S
T
I
N
L
Q
K
AWGAAR
R
V
S
K
D
D
W
L
E
W
L
R
R
L
S
L
E
L
LKDSS
S
P
S
L
R
S
CWALAQAY
N
P
M
A
R
D
LFN
A
A
F
V
S
C
W
S
EL
N
E
D
Q
Q
D
E
L
I
R
S
I
E
L
A
L
T
S
Q
D
I
AE
V
T
Q
T
L
L
N
L
A
E
F
M
E
H
S
D
KGPLPLRDD
N
G
I
V
L
L
G
E
R
AAKCRAY
A
K
A
L
H
Y
K
E
L
E
F
Q
K
G
P
T
P
A
I
L
E
S
L
I
S
I
N
N
K
L
QQP
E
A
A
A
G
V
L
E
Y
A
M
K
H
F
G
E
L
E
I
Q
A
T
W
Y
E
K
L
H
E
W
E
D
A
L
V
A
Y
-
D
K
K
M
D
T
N
K
D
-
D
P
E
L
M
L
G
R
M
--
R
C
L
E
A
L
G
E
W
G
Q
L
H
Q
Q
C
C
E
K
---------------------
W
T
L
V
N
D
E
T
Q
A
K
M
A
--
R
----
M
A
A
A
A
A
W
G
L
G
Q
W
D
S
M
E
E
Y
T
C
M
I
P
R
D
T
H
D
G
A
F
Y
R
A
V
L
A
L
H
Q
D
L
F
S
L
A
Q
Q
C
I
D
K
A
R
D
L
L
-------
D
A
E
L
T
A
M
A
G
E
S
--
Y
----------
S
---------
R
A
Y
G
A
M
-----
V
S
C
H
--
M
L
S
E
-
L
E
E
V
--
I
--------
Q
Y
K
L
VPERREI
I
R
Q
I
W
W
E
R
L
Q
G
C
Q
R
---
I
V
E
D
W
Q
-
K
I
L
M
V
R
S
L
V
V
S
P
H
E
D
M
R
T
W
L
---
K
Y
A
S
L
C
G
K
S
G
R
L
A
L
A
H
K
-
T
L
V
L
L
L
G
V
D
P
S
R
Q
L
D
H
P
-------
L
---
P
T
V
H
P
Q
V
T
-
Y
-
A
Y
-
M
K
N
M
W
K
S
--
A
R
K
I
D
A
F
Q
H
M
Q
---
H
F
V
Q
T
M
Q
Q
Q
A
Q
H
A
I
A
------
T
E
D
Q
Q
H
K
Q
E
L
H
K
L
M
A
R
C
F
L
K
L
G
E
W
Q
-
L
N
L
Q
G
I
N
E
S
T
I
P
-------
K
V
---
L
Q
Y
Y
S
A
A
T
E
H
-
D
R
S
W
Y
K
--------------------
A
W
H
A
W
A
V
M
N
F
E
A
V
L
H
Y
K
H
Q
N
Q
A
-
R
D
E
K
K
K
V
T
E
D
L
S
K
T
L
L
M
Y
T
V
P
A
V
Q
G
F
F
R
S
I
S
L
S
R
G
N
N
L
Q
D
T
L
R
V
L
T
L
W
F
D
YG
H
W
--
P
D
V
N
E
A
L
V
E
G
V
K
A
-
I
-
Q
I
-
D
T
W
L
Q
V
I
P
Q
L
I
A
R
I
D
T
--
P
R
-
P
------------------
L
----------------------------
V
-
G
R
L
I
H
Q
L
L
T
D
I
G
R
Y
H
P
Q
A
L
I
Y
P
L
T
V
A
----------------
S
K
S
-
T
T
T
A
R
H
N
A
A
N
K
I
L
K
N
M
C
E
H
S
N
T
L
V
Q
---
Q
---
A
M
M
V
S
E
E
L
I
R
V
A
-------
I
L
W
H
E
M
W
H
E
G
L
E
E
A
S
R
L
Y
F
G
E
R
N
V
K
G
M
F
E
V
L
E
P
L
H
A
M
M
E
R
G
--------------
P
Q
T
L
K
E
T
S
F
N
Q
A
Y
G
R
D
L
M
E
A
Q
E
W
C
R
K
Y
M
K
S
G
-
N
V
K
D
L
T
Q
A
W
D
L
Y
Y
H
V
F
R
R
I
S
K
Q
----------------
L
P
Q
L
T
S
L
E
L
Q
Y
V
S
P
K
L
L
M
C
R
D
L
E
L
A
V
P
G
T
Y
D
P
N
Q
-
P
I
I
R
I
Q
S
I
A
--
P
S
L
Q
V
I
T
S
-
K
Q
R
P
R
K
L
T
L
M
---------------------
G
S
N
G
H
E
F
V
F
L
L
K
G
H
E
D
L
R
Q
D
E
R
V
M
Q
L
F
G
L
V
N
T
L
L
A
N
D
P
T
S
--
L
R
K
N
-----
L
S
I
Q
R
Y
A
V
I
P
L
S
T
N
S
G
L
I
G
W
V
P
H
---
C
D
T
L
H
A
L
I
R
D
Y
R
E
K
K
K
I
L
L
N
I
E
H
R
I
M
L
R
M
A
P
D
Y
D
H
L
T
L
M
Q
--
K
V
------
E
V
F
E
H
A
V
------
N
N
TAGD
D
------------
L
A
K
L
L
W
L
K
----
S
P
--
S
----
S
E
----
V
----
W
F
D
R
R
T
N
Y
T
R
S
L
A
V
M
S
M
V
G
Y
I
L
G
L
G
D
R
H
P
S
N
L
M
L
D
R
L
S
G
K
I
L
H
I
D
F
G
----
D
C
F
E
V
A
M
T
R
-----
E
K
F
P
E
K
I
P
F
R
L
T
R
M
L
T
N
A
---
M
-----
E
V
T
G
L
D
G
N
Y
R
I
T
C
H
T
V
M
E
V
L
R
E
H
K
D
S
V
M
A
V
L
E
A
F
V
Y
-------------
D
P
L
L
N
W
R
L
M
D
T
N
T
A
L
---
N
K
K
A
I
Q
I
I
N
R
V
R
D
K
L
T
-
G
-
R
D
F
S
H
D
-
D
T
L
D
V
P
T
Q
V
E
L
L
I
K
Q
A
T
S
H
E
N
L
C
Q
CYIGWCPFW
17
PsiBlast_PDB
48.30
42%
-13
- C3 -
-
2X6J
1
?
A:
[441-695]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
I
F
K
H
G
D
D
L
R
Q
D
Q
L
I
L
Q
M
I
T
L
M
D
K
L
L
R
R
E
N
L
D
L
K
L
T
P
Y
K
V
L
A
T
S
S
K
H
G
F
L
Q
Y
V
D
--
S
C
------
T
V
A
E
V
L
A
------
R
E
G---
N
------------
I
H
N
F
F
R
K
H
HPCD
N
G
--
P
----
Y
G
----
I
----
S
A
E
V
M
D
T
Y
I
K
S
C
A
G
Y
C
V
I
T
Y
L
L
G
V
G
D
R
H
L
D
N
L
L
L
T
T
-
N
G
K
L
F
H
I
D
F
G
----
Y
I
L
G
R
D
P
K
P
-----
M
P
P
P
M
K
L
-
S
K
E
M
V
E
A
M
G
G
---
I
-----
S
S
E
H
H
-
H
E
F
R
K
Q
C
Y
T
A
Y
L
H
L
R
R
H
A
N
V
M
L
N
L
F
S
L
M
V
D
A
-
T
V
P
D
-
I
A
L
E
---
P
D
K
A
V
K
K
V
E
E
N
L
Q
L
G
L
T
D
E
E
A
V
Q
H
L
Q
S
L
L
D
V
S
I
-
T
-
A
V
M
P
A
L
V
E
Q
I
H
R
F
T
Q
Y
W
R
----------------------
5
PsiBlast_PDB
48.20
42%
-18
- C3 -
-
3LS8
2
PK3C3_HUMAN
A:
[354-606]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
L
F
F
K
T
E
D
G
G
K
Y
P
V
--
I
F
K
H
G
D
D
L
R
Q
D
Q
L
I
L
Q
I
I
S
L
M
D
K
L
L
R
K
E
N
L
D
L
K
L
T
P
Y
K
V
L
A
T
S
T
K
H
G
F
M
Q
F
I
Q
--
S
V
P
V
A
E
V
L
D
T
E
G
S
I
Q
------
N
-----
F
------------
F
R
K
Y
A
P
S
E
----
N
G
--
P
----
N
G
----
I
----
S
A
E
V
M
D
T
Y
V
K
S
C
A
G
Y
C
V
I
T
Y
I
L
G
V
G
D
R
H
L
D
N
L
L
L
T
K
-
T
G
K
L
F
H
I
D
F
G
----
Y
I
L
G
R
D
P
K
P
-----
L
P
P
P
M
K
L
-
N
K
E
M
V
E
G
M
G
G
---
T
-----
Q
S
E
Q
Y
-
Q
E
F
R
K
Q
C
Y
T
A
F
L
H
L
R
R
Y
S
N
L
I
L
N
L
F
S
L
M
V
D
A
-
N
I
P
D
-
I
A
L
E
---
P
D
K
T
V
K
K
V
Q
D
K
F
R
L
D
L
S
D
E
E
A
V
H
Y
M
Q
S
L
I
D
E
S
V
-
H
-
A
L
F
-------------------------------------
13
PsiBlast_PDB
48.16
42%
-14
- C3 -
-
5ANL
1
PK3C3_HUMAN
A:
[341-591]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
L
F
F
K
T
E
D
G
G
K
Y
P
V
--
I
F
K
H
G
D
D
L
R
Q
D
Q
L
I
L
Q
I
I
S
L
M
D
K
L
L
R
K
E
N
L
D
L
K
L
T
P
Y
K
V
L
A
T
S
T
K
H
G
F
M
Q
F
I
Q
--
S
V
P
V
A
E
V
L
D
T
E
G
S
I
Q
------
N
-----
F
------------
F
R
K
Y
A
P
S
E
----
N
G
--
P
----
N
G
----
I
----
S
A
E
V
M
D
T
Y
V
K
S
C
A
G
Y
C
V
I
T
Y
I
L
G
V
G
D
R
H
L
D
N
L
L
L
T
K
-
T
G
K
L
F
H
I
D
F
G
----
Y
I
L
G
R
D
P
K
P
-----
L
P
P
P
M
K
L
-
N
K
E
M
V
E
G
M
G
G
---
T
-----
Q
S
E
Q
Y
-
Q
E
F
R
K
Q
C
Y
T
A
F
L
H
L
R
R
Y
S
N
L
I
L
N
L
F
S
L
M
V
D
A
-
N
I
P
D
-
I
A
L
E
---
P
D
K
T
V
K
K
V
Q
D
K
F
R
L
D
L
S
D
E
E
A
V
H
Y
M
Q
S
L
I
D
E
S
V
-
H
-
A
---------------------------------------