@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_24_2410: (2018-03-10 )
MPPKRPQALEKLHVAPHDKAVSITDTMTLVVKGEGGVEMRVKQTGIAQGPGSSSASGQPKSDAVMNKIKFEDLRIGSELGKGSQGKVRVAQHKITGEKYAMKYIAFDGDSDDMRSALEAELRQVAAVKHHNIVSSYEAFFRDGRLYVVLEYMDCGTMNNLIDRHPEGFSEDMLAYIARELFKGLEFLHHLNMIHRDIKPANVLANTKGEIKISDFGVAKTLSGGDLQTLSAQGSVPYMSPERIQSKPYSFNSDIWSAGLTIAECAFREYPFASLKPKVFELCQAIASGTAKINWDDRETKFSDEFKEFIELCLRPEATRPSATEMLSHSLIQKASNVNPLEAGRWMSPKK
Atome Classification :
(20 SA)
-----------------------------------------------------------------------.........10........20........30........40........50........60........70..----------......80........90........100..-.....---110.......120.......130--........140.......150.......160--....---....170.......180.......190.-......200.....---..210.......220.......230.......240.......250.......260.......270....-.----.--.280....--------...290.......300.......310.--..-...-.------320.......330.......340.......350------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-----------------------------------------------------------------------MPPKR
P
Q
A
L
E
K
L
HVAPHD
K
A
V
S
I
T
D
T
M
T
L
V
V
KGEG
G
V
E
M
R
V
K
QTGIAQGPGSSSASGQP
K
S
D
A
V
M
N
KIK
F
E
D
L----------RI
G
S
ELGKGSQG
K
V
R
V
A
Q
HKITGE
K
Y
A
M
K
Y
I
-
A
FDGD---
S
D
D
M
R
S
A
L
E
A
E
L
R
Q
V
A
A
V
K
H
H
N
---
I
V
S
S
Y
E
A
F
F
RD
G
R
L
Y
V
V
L
E
YMDCG
T
M
N
N
L
I
---DRHP---EGF
S
E
D
M
L
A
Y
I
A
R
E
L
F
K
G
L
E
F
L
H
H
L
N
M
I
-
H
RDIK
P
A
N
VLANTK---G
E
I
K
I
SDFG
V
A
K
TLSGGD
L
Q
T
LSAQGSVPYM
S
P
E
R
IQSKPYSFNS
D
I
W
SAG
L
T
I
A
E
C
A
F
REYPFASL
K
P
-
K
----
V
--
F
E
L
C
Q
A
I
A--------SG
T
A
K
I
NWDDRET
K
F
S
D
E
F
K
E
F
I
E
L
CL--RP-EAT-R------
P
S
A
T
E
M
L
S
H
S
L
I
Q
K
ASNVNPLEAGRWMSPKK--------------------------------------------------------
9
PsiBlast_PDB
74.76
32%
-45
- C1 -
-
4ANB
2
MP2K1_HUMAN
A:
[3-276]
---------------------------------------------------------------------------------------------------------------------------------------
L
G
E
L
K
D
D
D
F
----------
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
-
H
L
E
-
I
---
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
L
H
E
C
N
S
P
Y
---
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
---
K
K
A
G
---
R
-
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
---
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
--
D
E
M
A
N
E
F
V
G
T
R
S
Y
M
S
P
E
R
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
R
P
P
M
---
A
----
I
--
F
E
L
L
D
Y
I
V
--------
N
E
P
P
P
---
K
L
P
S
A
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I-
K
N
-
P
A
E
-
R
------
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
-
S
D
A
E
E
V
D
F
A
G
W
L
------------------------------------------------------------
8
PsiBlast_PDB
74.21
32%
-44
- C1 -
-
4AN9
2
MP2K1_HUMAN
A:
[3-276]
---------------------------------------------------------------------------------------------------------------------------------------
L
G
E
L
K
D
D
D
F
----------
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
-
H
L
E
-
I
---
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
L
H
E
C
N
S
P
Y
---
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
---
K
K
A
G
---
R
-
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
---
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
--
D
E
M
A
N
E
-
V
G
T
R
S
Y
M
S
P
E
R
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
R
P
P
M
---
A
----
I
--
F
E
L
L
D
Y
I
V
--------
N
E
P
P
P
---
K
L
P
S
A
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I-
K
N
-
P
A
E
-
R
------
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
-
S
D
A
E
E
V
D
F
A
G
W
L
------------------------------------------------------------
10
PsiBlast_PDB
73.89
32%
-52
- C1 -
-
3ORN
3
MP2K1_HUMAN
A:
[2-283]
-----------------------------------------------------------------------------------------------------------------------------------------
E
L
K
D
D
D
F
----------
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
-
H
L
E
-
I
---
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
L
H
E
C
N
S
P
Y
---
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
---
K
K
A
G
---
R
-
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
---
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
--
D
S
M
A
N
S
F
V
G
T
R
S
Y
M
S
P
E
R
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
----PMA-
I
--
F
E
L
L
D
Y
I
V
--------
N
E
P
P
P
---
K
L
P
S
G
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I-
K
N
-
P
A
E
-
R
------
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
-
S
D
A
E
E
V
D
F
A
G
W
L
------------------------------------------------------------
6
PsiBlast_PDB
73.55
32%
-48
- C1 -
-
4AN2
2
MP2K1_HUMAN
A:
[3-276]
---------------------------------------------------------------------------------------------------------------------------------------
L
G
E
L
K
D
D
D
F
----------
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
-
H
L
E
-
I
---
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
L
H
E
C
N
S
P
Y
---
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
---
K
K
A
G
---
R
-
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
---
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
--
D
E
M
A
N
E
F
V
G
T
R
S
Y
M
S
P
E
R
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
R
P
P
M
---
A
----
I
--
F
E
L
L
D
Y
I
V
--------
N
E
P
P
P
---
K
L
P
S
A
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I-
K
N
-
P
A
E
-
R
------
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
-
S
D
A
E
E
V
D
F
A
G
W
L
------------------------------------------------------------
7
PsiBlast_PDB
73.46
32%
-48
- C1 -
-
4AN3
2
MP2K1_HUMAN
A:
[3-276]
---------------------------------------------------------------------------------------------------------------------------------------
L
G
E
L
K
D
D
D
F
----------
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
-
H
L
E
-
I
---
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
L
H
E
C
N
S
P
Y
---
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
---
K
K
A
G
---
R
-
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
---
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
--
D
E
M
A
N
E
--
G
T
R
S
Y
M
S
P
E
R
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
R
P
P
M
---
A
----
I
--
F
E
L
L
D
Y
I
V
--------
N
E
P
P
P
---
K
L
P
S
A
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I-
K
N
-
P
A
E
-
R
------
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
-
S
D
A
E
E
V
D
F
A
G
W
L
------------------------------------------------------------
12
PsiBlast_PDB
72.64
32%
-48
- C1 -
-
3WIG
3
MP2K1_HUMAN
A:
[2-283]
-----------------------------------------------------------------------------------------------------------------------------------------
E
L
K
D
D
D
F
----------
E
K
I
S
E
L
G
A
G
---
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
-
H
L
E
-
I
---
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
L
H
E
C
N
S
P
Y
---
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
---
K
K
A
G
---
R
-
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
---
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
--
D
S
M
A
N
S
F
V
G
T
R
S
Y
M
S
P
E
R
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
----PPMA
I
--
F
E
L
L
D
Y
I
V
--------
N
E
P
P
P
---
K
L
P
S
G
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I-
K
N
-
P
A
E
-
R
------
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
-
S
D
A
E
E
V
D
F
A
G
W
L
------------------------------------------------------------
11
PsiBlast_PDB
72.47
32%
-49
- C1 -
-
3OS3
2
MP2K1_HUMAN
A:
[2-283]
-----------------------------------------------------------------------------------------------------------------------------------------
E
L
K
D
D
D
F
----------
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
-
H
L
E
-
I
---
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
L
H
E
C
N
S
P
Y
---
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
---
K
K
A
G
---
R
-
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
---
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
--
D
S
M
A
N
S
F
V
G
T
R
S
Y
M
S
P
E
R
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
------MA--
I
--
F
E
L
L
D
Y
I
V
--------
N
E
P
P
P
---
K
L
P
--
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I-
K
N
-
P
A
E
-
R
------
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
-
S
D
A
E
E
V
D
F
A
G
W
L
------------------------------------------------------------
15
PsiBlast_PDB
69.03
34%
-47
- C1 -
-
4QMN
1
STK24_HUMAN
A:
[36-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
-
D
L
E
-
E
---
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
---
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
---
E
P
G
P
-----
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
H
---
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
----
V
--
L
F
L
I
---------------
P
K
N
N
P
P
T
L
E
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
--
N
K
-
E
P
S
F
R
------
P
T
A
K
E
L
L
K
H
K
F
I
---------------------------------------------------------------------------
13
PsiBlast_PDB
68.40
34%
-51
- C1 -
-
4QML
2
STK24_HUMAN
A:
[36-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
-
D
L
E
-
E
---
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
---
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
---
E
P
G
P
-----
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
H
---
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
----
V
--
L
F
L
I
---------------
P
K
N
N
P
P
T
L
E
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
--
N
K
-
E
P
S
F
R
------
P
T
A
K
E
L
L
K
H
K
F
I
---------------------------------------------------------------------------
4
PsiBlast_PDB
68.02
32%
-47
- C1 -
-
3SLS
2
MP2K1_HUMAN
A:
[19-296]
---------------------------------------------------------------------------------------------------------------------------------------
V
G
E
L
K
D
D
D
F
----------
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
-
H
L
E
-
I
---
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
L
H
E
C
N
S
P
Y
---
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
---
K
K
A
G
---
R
-
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
---
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
--------
F
V
G
T
R
S
Y
M
S
P
E
R
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
G
------A---
I
--
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
G
V
-----------
F
S
L
E
F
Q
D
F
V
N
K
C
L
I-
K
N
-
P
A
E
-
R
------
A
D
L
K
Q
L
M
V
H
A
F
I
-
K
R
S
D
A
E
E
V
D
F
A
G
W
L
------------------------------------------------------------
16
PsiBlast_PDB
67.83
34%
-48
- C1 -
-
4QMO
3
STK24_HUMAN
A:
[36-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
-
D
L
E
-
E
---
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
---
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
---
E
P
G
P
-----
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
H
---
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
----
V
--
L
F
L
I
---------------
P
K
N
N
P
P
T
L
E
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
--
N
K
-
E
P
S
F
R
------
P
T
A
K
E
L
L
K
H
K
F
I
---------------------------------------------------------------------------
19
PsiBlast_PDB
67.80
34%
-46
- C1 -
-
4QMS
2
STK24_HUMAN
A:
[36-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
-
D
L
E
-
E
---
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
---
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
---
E
P
G
P
-----
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
H
---
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
----
V
--
L
F
L
I
---------------
P
K
N
N
P
P
T
L
E
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
--
N
K
-
E
P
S
F
R
------
P
T
A
K
E
L
L
K
H
K
F
I
---------------------------------------------------------------------------
14
PsiBlast_PDB
66.34
34%
-47
- C1 -
-
4QMM
3
STK24_HUMAN
A:
[36-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
-
D
L
E
-
E
---
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
---
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
---
E
P
G
P
-----
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
H
---
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
----
V
--
L
F
L
I
---------------
P
K
N
N
P
P
T
L
E
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
--
N
K
-
E
P
S
F
R
------
P
T
A
K
E
L
L
K
H
K
F
I
---------------------------------------------------------------------------
49
Fugue
66.17
27%
44
- C1 -
-
3C4Z
1
RK_BOVIN
A:
[31-533]
RD
R
K
Y
L
A
R
LKLPPLSKC
E
A
L
R
E
S
LDLGFEGMCLEQ
P
I
G
K
R
L
F
Q
Q
F
L
R
T
H
EQH
G
P
A
L
Q
L
W
K
D
I
E
D
Y
D
T
ADDA
L
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
E
P
Q
A
Q
L
F
C
S
F
L
D
A
E
T
V
A
R
A
R
A
G
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
QPMGEDW
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
K
A
T
G
K
L
Y
A
C
K
K
L
N
K
K
R
L
K
---
K
R
K
G
Y
Q
G
A
M
V
E
K
K
I
L
A
K
V
H
S
R
F
---
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
YNV
D
E
D
N
---
P
G
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
R
N
I
I
-
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
---
G
N
V
R
I
S
D
L
G
L
A
V
E
L
K
A
G
Q
T
K
T
K
G
Y
A
G
T
P
G
F
M
A
P
E
L
L
L
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
R
A
R
G
E
-
K
----
V
E
N
K
E
L
K
Q
R
V
L
--------
E
Q
A
V
T
Y
-----
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
--
Q
K
-
D
P
E
-
K
RLGFRD
G
S
C
D
G
L
R
T
H
P
L
F
-
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
SRTVYAKNGAFSG
V
A
F
E
K
A
D
T
E
F
F
Q
E
F
A
SGTC
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
VWRP
20
PsiBlast_PDB
65.38
34%
-46
- C1 -
-
4QMT
2
STK24_HUMAN
A:
[36-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
-
D
L
E
-
E
---
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
---
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
---
E
P
G
P
-----
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
H
---
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
----
V
--
L
F
L
I
---------------
P
K
N
N
P
P
T
L
E
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
--
N
K
-
E
P
S
F
R
------
P
T
A
K
E
L
L
K
H
K
F
I
---------------------------------------------------------------------------
18
PsiBlast_PDB
65.29
34%
-46
- C1 -
-
4QMQ
3
STK24_HUMAN
A:
[36-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
-
D
L
E
-
E
---
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
---
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
---
E
P
G
P
-----
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
H
---
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
----
V
--
L
F
L
I
---------------
P
K
N
N
P
P
T
L
E
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
--
N
K
-
E
P
S
F
R
------
P
T
A
K
E
L
L
K
H
K
F
I
---------------------------------------------------------------------------
17
PsiBlast_PDB
65.14
34%
-49
- C1 -
-
4QMP
2
STK24_HUMAN
A:
[36-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
-
D
L
E
-
E
---
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
---
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
---
E
P
G
P
-----
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
H
---
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
----
V
--
L
F
L
I
---------------
P
K
N
N
P
P
T
L
E
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
--
N
K
-
E
P
S
F
R
------
P
T
A
K
E
L
L
K
H
K
F
I
---------------------------------------------------------------------------
29
HHSearch
63.36
28%
-95
- C1 -
-
4XBR
1
INKA1_HUMAN (first)
A:
[94-353]
---------------------------------------------------------------------------------------------------------------------------------------------
S
Y
L
----------
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
-
D
L
R
K
-----
Q
Q
R
R
E
L
L
F
N
E
V
V
I
M
R
D
Y
Q
H
E
N
---
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
---
T
H
-----
T
R
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
-
H
R
D
I
K
S
D
S
I
L
L
T
H
D
---
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
R
L
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
-
L
--------
K
A
M
K
M
I
R
--------
D
N
L
P
P
-
R
L
-
K
N
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
--
V
R
D
P
A
Q
-
R
------
A
T
A
A
E
L
L
K
H
P
F
L
A
K
A
G
P
P
---------------------------------------------------------------------
3
PsiBlast_PDB
62.01
32%
-18
- C1 -
-
5DH3
1
STK3_HUMAN
A:
[34-289]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
G
E
G
S
Y
G
S
V
F
K
A
I
H
K
E
S
G
Q
V
V
A
I
K
Q
V
-
P
V
E
S
D
----------
L
Q
E
I
I
K
E
I
S
I
M
Q
Q
C
D
SPY
V
V
K
Y
Y
G
S
Y
F
K
N
T
D
L
W
I
V
M
E
Y
C
G
A
G
S
V
S
D
I
I
---
R
L
R
N
---
K
T
L
I
E
D
E
I
A
T
I
L
K
S
T
L
K
G
L
E
Y
L
H
F
M
R
K
I
-
H
R
D
I
K
A
G
N
I
L
L
N
T
E
---
G
H
A
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
M
A
K
R
N
T
V
I
G
T
P
F
W
M
A
P
E
V
I
Q
E
I
G
Y
N
C
V
A
D
I
W
S
L
G
I
T
S
I
E
M
A
E
G
K
P
P
Y
A
D
I
H
P
M
R
----
A
--
I
F
M
I
P
T
N
P
--------
P
P
T
F
R
-----
K
P
E
L
W
S
D
D
F
T
D
F
V
K
K
C
L
VK
N
P
-
E
-
Q
-
R
------
A
T
A
T
Q
L
L
Q
H
P
F
I
K
N
A
K
P
V
S
I
L
------------------------------------------------------------------
22
HHSearch
60.04
27%
-17
- C1 -
-
3C0G
1
CSKP_HUMAN
B:
[22-294]
-------------------------------------------------------------------------------------------------------------------------------------------
F
E
D
V
Y
----------
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
-
D
V
A
K
F
T
S
S
P
G
L
S
T
E
D
L
K
R
E
A
S
I
C
H
M
L
K
H
P
H
---
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
---
V
K
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
-
H
R
D
V
K
P
H
C
V
L
L
A
S
K
ENS
A
P
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
S
G
L
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
R
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
K
E
-
R
----
L
-----
F
E
G
I
I
--------
K
G
K
Y
K
M
N
P
-
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
--
M
L
D
P
A
E
-
R
------
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
-----------------------------------------------------------------------