@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_25_0690: (2018-03-10 )
MDLSPLQLHDEAAPLRRSTGVAATFGGLSPPLPSERQSIDQPRRHKSDKHHHISRDSSPNPTIGSCSGDAPTSQASLPLLAGMMASRKELFTELAIPSTQSMNGQQQAQGMSSSPADAAQPSTSQDGVGTASRALSPRALSTLGSLGPSGPVAGLLATSPPGKDLSNAALRGGFLSESISLVESSVSSISRSALRLHRGRARDRLPSDREDSSGMGGGRNDDVPSQVQLPPITRSLTSASASLRGRQFPTALQELEGSSAGIGLPTLSCSSSLNSMRHEDEGPCLAPALKIVLEASAAVGQPPRPLHPAALPRSSDERCDVDSIKPSSSFSLVQSARRAIAMGMGSDDDAKTRGHQPTPIEVSDRGDGTTMLATAPVSLTVEAAPLTLTGGLTGQSSSRNSTGMRQTTCANTPAFPFEKNAAVTPIANSGFSRFDTAVLESGDYAPEATRPPTGERSSGPKHGSLQSLDHDNYTTAARGATGQQRPSDSIENDDAAHQKRAKRRLRKTRKKGKAKRQKNGEAVAEGENGVAVDSLKAAAVAHRSDSALARKRERKRQLKHEKMKEMSSEERRQYKAEHQRRRAAKKAMRSSAAAASPHLEHDNHGDWSGSRPYHSSDPSASFSPAPVPTAGAVKQHPPLSSSPELSQPLAPVTAAAADPDAKMTSSHARQPSTKSEVEQSVPSLVDRSSLEDLAATLSPQVLASTCSASTNALADGSSSLLKAFQGRRCTSASGGGAPVVPSTAYPSKLMSSTPMPFRRRLFTDIAGRPQHQGGTNSFLHVSSSTPANVSGLEGQLQVHNADAEGFGMEHDATLEASGGSADNYDDNESRGPPRRQPMDESGSVVDVVPERAPMPDGGALSPSPHLPAAAAGSGTAAILELKQQQEVQQRYRLPSLAAGTSLAAMLVSVANANGDVASADASEASLMTASAPGRGADHCQGSSLPLRPDAKTSQSVEPGLNQSPTGDALTGAVTKGTAVMPVTSMSYCSAYSRSHTRDWEPAAVEPAVKGAGGAEGCGAGQKALTPAAAVSAAMAAARKARRSPSSSCSSLRSRSSDDESADGSSGYSYSSYSSSGSLVPEVLQLVGGCTVPPPVAAFSDLKYRYSCVPQLHSYAEPAIIHEWNLAEGCWGSVETSVVLNPQPFSKGNMRASYYMIDMRRLNCLLVAKRYLRSTVRDDQYFDDVSMHSIAGHWARAFNMMHPPKEVRFVPAAVLVLPKRNPPLILAMEPQLTGKFVKYNNNCGYVRRKARWTPQAFSHFTYHASNHELMVVDIQGVDDYYTDPQILSSDGEGYGRGNLGEEGIRRFLESHRCNEVCRAVGLPPLQRNAKGAVITPLASPGSGRSSAGPGTPAAKDRLNTAMPCASGLKEERLPPKAFVLARRASSGNTPGQEHNGVQLGSRQPSETNLMLSPAPPPRQTLHTGSRPSSPSPLAAAPSALTPGALPHRVGPVQNCGVKYVRYPRQALIRPQSQYFVSTVAGGLMSVPPQGSSVPNGYGSGSSFSALQSYPPASEQSGGAPSGMAGVGHASTSPPPQGSVMVAVPLLRPPAGGRPGYAGAQSSVSPEGFHLLTAPRSGENVGSLHQTPHVRPSGTTNLGGGVPNFYPHPPVTGAVGSPTGRCASHQSSFAAVAPTIQSTEEVAMAHRPRSRRQSFSRRPVFSAVEEMPKRSESRYHGHPHLH
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140........1150.....------.----------------------------------1160------------------------------........1170...---.--.---------..-----------1180......1190......1200---.......1210----------......-----.-------------.---------.------1220--.-----........1230......1240..---..---..-1250......1260......1270.....----.1280....-----..1290--.--.--.......1300......1310......1320......-1330......1340......1350......1360......1370......1380......1390......1400......1410......1420......1430......1440......1450......1460......1470......1480......1490......1500......1510......1520......1530......1540......1550......1560......1570......1580......1590......1600......1610......1620......1630......1640......1650......1660......1670......1680
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MDLSPLQLHDEAAPLRRSTGV
A
A
TFGGLSPPLP
S
E
R
Q
SIDQPRRHKSDKHHHISRDSSPNPTIGSCSGDAPTSQA
S
L
P
L
L
A
G
M
M
A
S
R
K
E
L
F
T
E
LAIPSTQSMN
G
Q
Q
Q
AQGMSSSPADAAQPSTSQDGVG
T
A
S
RALS
P
R
A
L
S
T
L
GSLGPSGPVA
G
L
LATSPPGKD
L
S
N
A
A
LRGG
F
L
S
E
S
I
S
L
V
E
S
S
V
S
S
I
S
R
S
A
L
R
L
HRGRARDRLPSDREDSSGMGGGRNDDVPSQVQLPP
I
T
R
S
L
T
S
A
S
A
SLRGRQF
P
T
A
L
Q
E
LEGSSAGIGLPTL
S
C
S
S
S
L
N
S
M
RHEDEGP
C
L
A
P
A
L
K
I
V
L
EASAAVGQPPRPLHPAALPRSSDERCDVDSIKPSS
S
F
S
L
V
Q
S
A
R
R
A
I
A
MGMGSDDDAKTRGHQPT
P
I
E
V
SDRGD
G
T
T
M
L
A
TA
P
V
S
L
T
V
E
AA
P
L
T
L
TGGLTGQSSSRNSTGMRQTTCANTPAFPFEKNAAVTPIANSGF
S
R
F
D
T
A
V
LESGDYAPEATRPPTGERSSGPKHGSLQSLDHDNYTTAARGATGQQRPSDSIEN
D
D
A
A
H
Q
K
R
A
K
R
R
L
R
K
T
R
K
KGKAKRQKNGEAVAEGENG
V
A
V
D
S
L
K
A
A
A
V
AHRS
D
S
A
L
A
R
K
R
E
R
K
R
Q
L
K
H
E
K
M
K
E
M
S
S
E
E
R
R
Q
Y
K
A
E
H
Q
R
R
R
A
A
K
K
A
M
R
SSAAAASPHLEHDNHGDWSGSRPYHSSDPSASFSPAPVPTAGAVKQHPPLSSSPELSQPLAPVTAAAADPDAKM
T
S
S
HARQPS
T
K
S
E
V
E
Q
S
V
P
S
L
V
D
R
S
S
L
E
D
L
A
A
TL
S
P
Q
V
L
A
S
T
CSASTNALADG
S
S
S
L
L
K
A
F
QGRRCTSASGGGAPVVPSTAY
P
S
K
L
MSSTP
M
P
F
R
R
R
L
F
T
D
IAGRPQHQGGTN
S
F
L
H
VSSSTPANVSGLE
G
Q
L
Q
V
HNADAEGFGMEHD
A
T
L
EASGGSADNYDDNESRGPPRRQPMDESG
S
V
V
D
VVPERAPMPDGGALSPSPHLPAAAAGSG
T
A
A
I
L
E
L
K
Q
Q
Q
E
V
Q
Q
R
YRLPSLAA
G
T
S
L
A
A
M
L
V
S
V
ANANGDVASADASE
A
S
L
M
TASAPGRGADHCQGSSLPLRPDAKTSQSVEPGLNQSPTGDALTGAVTKG
T
A
V
M
P
VT
S
M
S
Y
C
S
A
YSRSHTRDWEPAAVEPAVKGAGGAEGCGAGQKAL
T
P
A
A
A
V
S
A
A
M
A
A
A
R
K
ARRSPS
S
S
C
S
S
L
RSRSSDDESADGSSG
Y
S
YSSYSSSG
S
L
V
P
E
V
L
Q
L
VGGCTVPP
P
V
A
A
F
SD
L
K
Y
R
Y
S
C
V
P
Q
L
H
SYAE
P
A
I
I
H
EWNLAEGCWGS
V
E
T
S
V
V
LNP--QPFSKGN
M
R
A
S
Y
Y
M
I
D
M
------
R
----------------------------------
R
L
--------------------------------
N
C
L
L
V
A
K
R
Y
L
R
-
S
T
V---R--D---------DQ-----------YFDDV
S
M
H
S
I
A
G
H
W
A
R
A
F
NMMH-P---PKE
V
R
F
V
P
-------------
A
A
V
L
V
L-----P-------------K---------R------N-----P-----
P
L
I
L
A
MEPQL
T
G
K
F
V
K
YNNNCGYV---RR---KA-RWT
P
Q
A
F
S
H
F
T
Y
HASN
H
E
L
M
V
V
D
I
QGVDD----YYTDP
Q
I
LS-----SDG-----E--G--YGRGNL
G
E
E
G
I
R
R
F
L
E
SH
R
C
N
E
V
C
R
AVGLPPLQRNAK-G
A
V
I
T
PLASPGSGRSSAGPGTPA
A
K
DRLNTAMPCASGLKEERLPPK
A
F
V
L
A
RRASSGNTPGQEHN
G
V
QLGSRQPSET
N
L
M
LSPAPPP
R
Q
TLHTGSRPSSPSPLAAAPSALTPGALPHRVGP
V
Q
NCGVKYVRY
P
R
Q
A
LIRP
Q
S
Q
Y
F
V
S
T
VAGGLMSVPPQGSSVPNGYGSGSS
F
S
A
L
QSYPPASEQSGGAPSGMAGVGHASTSPPPQG
S
V
M
V
A
V
P
L
LRPPAGGRPGYAGAQSSVSPE
G
F
H
L
L
TAPRSGENVGSLHQTPHVRPSGTTNLGGGVPNFYPHPPVTGAVGSPTGRCASHQSS
F
A
AVAPTIQ
S
T
E
E
V
A
M
AHRP
R
S
R
R
Q
SFSRR
P
V
F
S
A
V
E
E
M
P
K
RSESRYHGHPHLH
22
HHSearch
73.17
40%
12
- C1 -
-
3PDT
1
A:
[22-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
E
M
G
I
L
W
E
F
D
P
I
I
N
K
W
I
R
L
S
M
K
L
K
V
E
R
--
K
P
F
A
E
G
A
L
R
E
A
Y
H
T
V
S
L
------
G
V
G
T
DENYPLGTTKLFPPIEMISPISKNN
E
A
M
T
Q
L
K
N
--------------------------------
G
T
K
F
V
L
K
L
Y
K
K
-
E
--QQA
S
--
R
---------
E
L
-----------
Y
F
E
D
V
K
M
Q
M
V
C
R
D
W
G
N
K
F
N
Q
K
K
-
P
---
P
K
K
I
E
F
L
M
-------------
S
W
V
V
E
L
-----
I
-------------
D
---------
R
------
S
PSSNG
Q
-----
P
I
L
C
S
I
E
P
L
L
V
G
E
F
K
K
N
N
S
N
Y
G
A
V
---
L
T
----
N
-
R
S
T
P
Q
A
F
S
H
F
T
Y
E
L
S
N
K
Q
M
I
V
V
D
I
Q
G
V
D
D
----
L
Y
T
D
P
Q
I
H
T
-----
P
D
G
-----
K
--
G
--
F
G
L
G
N
L
G
K
A
G
I
N
K
F
I
T
T
H
K
C
N
A
V
C
A
L
L
D
L
D
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
72.34
37%
3
- C1 -
-
3LKM
1
A:
[22-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
E
M
G
I
L
W
E
F
D
P
I
I
N
K
W
I
R
L
S
M
K
L
K
V
E
R
--
K
P
F
A
E
G
A
L
R
E
A
Y
H
T
V
S
L
------
G
V
G
T
DENYPLGKLFPPIEMISPISKNN
E
A
M
T
Q
L
--
K
N
--------------------------------
G
T
K
F
V
L
K
L
Y
K
K
-
E
--QQA
S
--
R
---------
E
L
-----------
Y
F
E
D
V
K
M
Q
M
V
C
R
D
W
G
N
K
F
N
Q
K
K
-
P
---
P
K
K
I
E
F
L
M
-------------
S
W
V
V
E
L
-----
I
-------------
D
---------
R
------
S
PSSNG
Q
-----
P
I
L
C
S
I
E
P
L
L
V
G
E
F
K
K
N
N
S
N
Y
G
A
V
---
L
T
----
N
-
R
S
T
P
Q
A
F
S
H
F
T
Y
E
L
S
N
K
Q
M
I
V
V
D
I
Q
G
V
D
D
----
L
Y
T
D
P
Q
I
H
T
-----
P
D
G
-----
K
--
G
--
F
G
L
G
N
L
G
K
A
G
I
N
K
F
I
T
T
H
K
C
N
A
V
C
A
L
L
D
L
D
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
Fugue
72.11
39%
12
- C1 -
-
3LKM
1
A:
[22-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
E
M
G
I
L
W
E
F
D
P
I
I
N
K
W
I
R
L
S
M
K
L
K
V
E
R
--
K
P
F
A
E
G
A
L
R
E
A
Y
H
T
V
S
L
------
G
----------------------------------
V
G
T
DENYPLGKLFPPIEMISPISKNN
E
A
M
T
Q
L
KN
G
T
K
F
V
L
K
L
Y
K
K
E
Q
Q
A
---
S
--
R
---------
E
L
-----------
Y
F
E
D
V
K
M
Q
M
V
C
R
D
W
G
N
K
F
N
Q
K
K
-
P
---
P
K
K
I
E
F
L
M
-------------
S
W
V
V
E
L
IDRSP
S
-------------
S
---------
N
------
G
-----
Q
-----
P
I
L
C
S
I
E
P
L
L
V
G
E
F
K
K
N
N
S
N
Y
G
A
V
---
L
T
---
N
--
R
S
T
P
Q
A
F
S
H
F
T
Y
E
L
S
N
K
Q
M
I
V
V
D
I
Q
G
V
D
D
----
L
Y
T
D
P
Q
I
H
T
-----
P
D
G
-----
K
--
G
--
F
G
L
G
N
L
G
K
A
G
I
N
K
F
I
T
T
H
K
C
N
A
V
C
A
L
L
D
L
D
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
Fugue
61.62
26%
0
- C1 -
-
1IA9
2
TRPM7_MOUSE
A:
[3-280]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Y
Y
S
A
V
E
R
N
N
L
M
R
L
S
Q
S
I
P
F
V
P
V
--
P
P
R
G
E
P
V
T
V
Y
R
L
E
E
S
S
P
S
I
L
N
N
S
M
S
S
W
S
-------
Q
L
G
L
C
A
K
I
E
F
--
L
S
K
M
G
G
G
L
R
R
A
V
K
V
L
C
T
------
W
SEHDIL----------------------------
K
S
--------------------------------
G
H
L
Y
I
I
K
S
F
L
P
-
E
V
I
---
N
--
T
---------
W
S
SIYKED
T
V
L
H
L
C
L
R
E
I
Q
Q
Q
R
A
A
Q
K
L
T
F
A
F
N
Q
M
K
-
P
KSI
P
Y
S
P
R
F
L
E
-------------
V
F
L
L
Y
C
-----
H
-------------
S
---------
A
------
G
------------
Q
W
F
A
V
E
E
C
M
T
G
E
F
R
K
Y
N
N
N
N
G
D
E
IIP
T
N
---
T
L
-
E
E
I
M
L
A
F
S
H
W
T
Y
E
Y
T
R
G
E
L
L
V
L
D
L
Q
G
V
G
E
----
N
L
T
D
P
S
V
I
K
AEEKR
S
C
D
-----
M
--
V
--
F
G
P
A
N
L
G
E
D
A
I
K
N
F
R
A
K
H
H
C
N
S
C
C
R
K
L
K
L
P
D
L
K
R
N
D
Y
-
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
59.62
29%
24
- C1 -
-
1IA9
1
TRPM7_MOUSE
A:
[38-279]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
S
S
P
S
I
L
N
N
S
M
S
S
W
S
Q
L
G
L
C
A
K
I
E
F
L
S
K
--
M
G
G
G
L
R
R
A
V
K
V
L
C
T
WSEHDI
L
----------------------------------
K
S
--------------------------------
G
H
L
Y
I
I
K
S
F
L
P
-
E
V
I
---
N
T
W
S
SIYKED
T
V
L
H
L
-----------
C
L
R
E
I
Q
Q
Q
R
A
A
Q
K
L
T
F
A
F
N
Q
M
K
-
P
KSI
P
Y
S
P
R
F
L
E
-------------
V
F
L
L
Y
C
-----------------------------
H
------
S
-----
A
-----
G
Q
W
F
A
V
E
E
C
M
T
G
E
F
R
K
Y
N
N
N
N
G
D
E
---
I
I
PTN
T
L
-
E
E
I
M
L
A
F
S
H
W
T
Y
E
Y
T
R
G
E
L
L
V
L
D
L
Q
G
V
G
E
----
N
L
T
D
P
S
V
I
K
-----
A
E
E
KRSCD
M
--
V
--
F
G
P
A
N
L
G
E
D
A
I
K
N
F
R
A
K
H
H
C
N
S
C
C
R
K
L
K
L
P
D
L
K
R
N
D
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
59.38
28%
-35
* C1 *
-
4KUJ
-
?
B:
[41-269]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
N
Q
R
I
N
Q
F
L
F
Q
H
S
T
F
R
V
E
L
--
A
P
F
A
K
G
G
E
R
L
A
F
R
A
I
N
G
------------------------------------------
R
--------------------------------
G
D
R
I
V
L
K
R
F
F
Q
-
Q
R
----
P
--
L
---------
T
M
-----------
L
L
E
T
I
E
R
Q
L
I
C
I
Y
L
A
N
I
F
N
K
L
N
V
S
---
P
N
K
L
H
F
L
P
-------------
N
Y
L
F
I
P
-----
S
PTKDLDG
K
I
L
T
L
E
Q
---------
T
E
Q
A
V
A
A
T
-----
C
-----
R
T
P
N
F
V
E
P
Y
L
S
G
Y
F
I
K
Y
I
D
N
N
G
W
I
---
N
E
S--
E
F
-
H
S
T
L
H
A
F
A
H
W
T
W
V
H
T
K
G
A
L
L
I
C
D
I
Q
G
V
N
A
NNKF
Y
L
T
D
P
A
L
H
H
-----
I
D
Q
-----
N
KF
I
--
Y
S
E
T
N
L
G
E
V
G
I
S
Q
F
F
R
T
H
Q
C
N
A
I
C
Q
G
L
H
L
P
K
H
K
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
59.36
29%
31
- C1 -
-
1IAH
2
B:
[38-279]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
S
S
P
S
I
L
N
N
S
M
S
S
W
S
Q
L
G
L
C
A
K
I
E
F
LS
K
E
E
M
G
G
G
L
R
R
A
V
K
V
L
C
T
WSEHDI
L
----------------------------------
K
S
--------------------------------
G
H
L
Y
I
I
K
S
F
L
P
-
E
V
I
---
N
T
W
S
SIYKED
T
V
L
H
L
-----------
C
L
R
E
I
Q
Q
Q
R
A
A
Q
K
L
T
F
A
F
N
Q
M
K
-
P
KSI
P
Y
S
P
R
F
L
E
-------------
V
F
L
L
Y
C
-----------------------------
H
------
S
-----
A
-----
G
Q
W
F
A
V
E
E
C
M
T
G
E
F
R
K
Y
N
N
N
N
G
D
E
---
I
I
PTN
T
L
-
E
E
I
M
L
A
F
S
H
W
T
Y
E
Y
T
R
G
E
L
L
V
L
D
L
Q
G
V
G
E
----
N
L
T
D
P
S
V
I
K
-----
A
E
E
KRSCD
M
--
V
--
F
G
P
A
N
L
G
E
D
A
I
K
N
F
R
A
K
H
H
C
N
S
C
C
R
K
L
K
L
P
D
L
K
R
N
D
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
57.52
43%
-14
- C1 -
-
5E9E
1
MHCKA_DICDI
A:
[126-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
F
E
D
V
K
M
Q
M
V
C
R
D
W
G
N
K
F
N
Q
K
K
-
P
---
P
K
K
I
E
F
L
M
-------------
S
W
V
V
E
L
-----
I
-------------
D
---------
R
------
S
-----
P
SSNGQ
P
I
L
C
S
I
E
P
L
L
V
G
E
F
K
K
N
N
S
N
Y
G
A
V
---
L
T
---
N
--
R
S
T
P
Q
A
F
S
H
F
T
Y
E
L
S
N
K
Q
M
I
V
V
D
I
Q
G
V
D
D
----
L
Y
T
D
P
Q
I
H
T
-----
P
D
G
-----
K
--
G
--
F
G
L
G
N
L
G
K
A
G
I
N
K
F
I
T
T
H
K
C
N
A
V
C
A
L
L
D
L
-----
D
V
K
L
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
56.28
48%
-14
- C1 -
-
3PDT
1
A:
[126-271]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
F
E
D
V
K
M
Q
M
V
C
R
D
W
G
N
K
F
N
Q
K
K
-
P
---
P
K
K
I
E
F
L
M
-------------
S
W
V
V
E
L
-----
I
-------------
D
---------
R
------
S
-----
P
SSNGQ
P
I
L
C
S
I
E
P
L
L
V
G
E
F
K
K
N
N
S
N
Y
G
A
V
---
L
T
---
N
--
R
S
T
P
Q
A
F
S
H
F
T
Y
E
L
S
N
K
Q
M
I
V
V
D
I
Q
G
V
D
D
----
L
Y
T
D
P
Q
I
H
T
-----
P
D
G
-----
K
--
G
--
F
G
L
G
N
L
G
K
A
G
I
N
K
F
I
T
T
H
K
C
N
A
V
C
A
L
L
D
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
56.19
42%
-9
- C1 -
-
4ZME
1
MHCKA_DICDI
A:
[126-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
F
E
D
V
K
M
Q
M
V
C
R
D
W
G
N
K
F
N
Q
K
K
-
P
---
P
K
K
I
E
F
L
M
-------------
S
W
V
V
E
L
-----
I
-------------
D
---------
R
------
S
-----
P
SSNGQ
P
I
L
C
S
I
E
P
L
L
V
G
E
F
K
K
N
N
S
N
Y
G
A
V
---
L
T
---
N
--
R
S
T
P
Q
A
F
S
H
F
T
Y
E
L
S
N
K
Q
M
I
V
V
D
I
Q
G
V
D
D
----
L
Y
T
-
P
Q
I
H
T
-----
P
D
G
-----
K
--
G
--
F
G
L
G
N
L
G
K
A
G
I
N
K
F
I
T
T
H
K
C
N
A
V
C
A
L
L
D
L
-----
D
V
K
L
G
G
V
L
S
-----
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
56.16
48%
-25
- C1 -
-
5DYJ
1
MHCKA_DICDI
A:
[126-271]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
F
E
A
V
K
M
Q
M
V
C
R
D
W
G
N
K
F
N
Q
K
K
-
P
---
P
K
K
I
E
F
L
M
-------------
S
W
V
V
E
L
-----
I
-------------
D
---------
R
------
S
-----
P
SSNGQ
P
I
L
C
S
I
E
P
L
L
V
G
E
F
K
K
N
N
S
N
Y
G
A
V
---
L
T
---
N
--
R
S
T
P
Q
A
F
S
H
F
T
Y
E
L
S
N
K
Q
M
I
V
V
D
I
Q
G
V
D
D
----
L
Y
T
D
P
Q
I
H
T
-----
P
D
G
-----
K
--
G
--
F
G
L
G
N
L
G
K
A
G
I
N
K
F
I
T
T
H
K
C
N
A
V
C
A
L
L
D
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
55.51
43%
-20
- C1 -
-
3LKM
1
A:
[126-273]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
F
E
D
V
K
M
Q
M
V
C
R
D
W
G
N
K
F
N
Q
K
K
-
P
---
P
K
K
I
E
F
L
M
-------------
S
W
V
V
E
L
-----
I
-------------
D
---------
R
------
S
-----
P
SSNGQ
P
I
L
C
S
I
E
P
L
L
V
G
E
F
K
K
N
N
S
N
Y
G
A
V
---
L
T
---
N
--
R
S
T
P
Q
A
F
S
H
F
T
Y
E
L
S
N
K
Q
M
I
V
V
D
I
Q
G
V
D
D
----
L
Y
T
D
P
Q
I
H
T
-----
P
D
G
-----
K
--
G
--
F
G
L
G
N
L
G
K
A
G
I
N
K
F
I
T
T
H
K
C
N
A
V
C
A
L
L
D
L
-----
D
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
55.48
43%
-17
- C1 -
-
3LLA
1
MHCKA_DICDI
A:
[126-275]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
F
E
D
V
K
M
Q
M
V
C
R
D
W
G
N
K
F
N
Q
K
K
-
P
---
P
K
K
I
E
F
L
M
-------------
S
W
V
V
E
L
-----
I
-------------
D
---------
R
------
S
-----
P
SSNGQ
P
I
L
C
S
I
E
P
L
L
V
G
E
F
K
K
N
N
S
N
Y
G
A
V
---
L
T
---
N
--
R
S
T
P
Q
A
F
S
H
F
T
Y
E
L
S
N
K
Q
M
I
V
V
D
I
Q
G
V
D
D
----
L
Y
T
D
P
Q
I
H
T
-----
P
D
G
-----
K
--
G
--
F
G
L
G
N
L
G
K
A
G
I
N
K
F
I
T
T
H
K
C
N
A
V
C
A
L
L
D
L
-----
D
V
K
L---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
55.47
42%
-19
- C1 -
-
4ZS4
1
MHCKA_DICDI
A:
[126-273]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
F
E
D
V
K
M
Q
M
V
C
R
D
W
G
N
K
F
N
Q
K
K
-
P
---
P
K
K
I
E
F
L
M
-------------
S
W
V
V
E
L
-----
I
-------------
D
---------
R
------
S
-----
P
SSNGQ
P
I
L
C
S
I
E
P
L
L
V
G
E
F
K
K
N
N
S
N
Y
G
A
V
---
L
T
---
N
--
R
S
T
P
Q
A
F
S
H
F
T
Y
E
L
S
N
K
Q
M
I
V
V
A
I
Q
G
V
D
D
----
L
Y
T
D
P
Q
I
H
T
-----
P
D
G
-----
K
--
G
--
F
G
L
G
N
L
G
K
A
G
I
N
K
F
I
T
T
H
K
C
N
A
V
C
A
L
L
D
L
-----
D
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
54.91
42%
-12
- C1 -
-
4ZMF
1
MHCKA_DICDI
A:
[126-274]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
F
E
D
V
K
M
Q
M
V
C
R
D
W
G
N
K
F
N
Q
K
K
-
P
---
P
K
K
I
E
F
L
M
-------------
S
W
V
V
E
L
-----
I
-------------
D
---------
R
------
S
-----
P
SSNGQ
P
I
L
C
S
I
E
P
L
L
V
G
E
F
K
K
N
N
S
N
Y
G
A
V
---
L
T
---
N
--
R
S
T
P
Q
A
F
S
H
F
T
Y
E
L
S
N
K
Q
M
I
V
V
D
I
Q
G
V
D
D
----
L
Y
T
-
P
Q
I
H
T
-----
P
D
G
-----
K
--
G
--
F
G
L
G
N
L
G
K
A
G
I
N
K
F
I
T
T
H
K
C
N
A
V
C
A
L
L
D
L
-----
D
V
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
54.35
42%
-11
- C1 -
-
3LMI
1
MHCKA_DICDI
A:
[126-274]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
F
E
D
V
K
M
Q
M
V
C
R
D
W
G
N
K
F
N
Q
K
K
-
P
---
P
K
K
I
E
F
L
M
-------------
S
W
V
V
E
L
-----
I
-------------
D
---------
R
------
S
-----
P
SNG
Q
-
P
I
L
C
S
I
E
P
L
L
V
G
E
F
K
K
N
N
S
N
Y
G
A
V
---
L
T
---
N
--
R
S
T
P
Q
A
F
S
H
F
T
Y
E
L
S
N
K
Q
M
I
V
V
D
I
Q
G
V
D
D
----
L
Y
T
A
P
Q
I
H
T
-----
P
D
G
-----
K
--
G
--
F
G
L
G
N
L
G
K
A
G
I
N
K
F
I
T
T
H
K
C
N
A
V
C
A
L
L
D
L
-----
D
V
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
53.31
42%
-15
- C1 -
-
5E4H
-
MHCKA_DICDI
A:
[126-275]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
F
E
-
V
K
M
Q
M
V
C
R
D
W
G
N
K
F
N
Q
K
K
-
P
---
P
K
K
I
E
F
L
M
-------------
S
W
V
V
E
L
-----
I
-------------
D
---------
R
------
S
-----
P
SSNGQ
P
I
L
C
S
I
E
P
L
L
V
G
E
F
K
K
N
N
S
N
Y
G
A
V
---
L
T
---
N
--
R
S
T
P
Q
A
F
S
H
F
T
Y
E
L
S
N
K
Q
M
I
V
V
D
I
Q
G
V
D
D
----
L
Y
T
D
P
Q
I
H
T
-----
P
D
G
-----
K
--
G
--
F
G
L
G
N
L
G
K
A
G
I
N
K
F
I
T
T
H
K
C
N
A
V
C
A
L
L
D
L
-----
D
V
K
L---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
53.04
28%
-22
- C1 -
-
4KUJ
1
?
A:
[62-265]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
F
A
K
G
G
E
R
L
A
F
R
A
I
N
G
------
R
--------------------------------------------------------------------
G
D
R
I
V
L
K
R
F
F
Q
-
Q
R
P
---
L
--
T
----------
M
-----------
L
L
E
T
I
E
R
Q
L
I
C
I
Y
L
A
N
I
F
N
K
L
N
V
S
---
P
N
K
L
H
F
L
P
N
Y
L
F
I
P
S
PTKDLD
G
K
I
L
T
L
-----
E
-------------
Q
T
E
Q
A
V
A
A
T
C
R
------
T
-----
P
-----
N
F
V
---
E
P
Y
L
S
G
Y
F
I
K
Y
I
D
N
N
G
W
I
---
N
E
---
S
E
F
H
S
T
L
H
A
F
A
H
W
T
W
V
H
T
K
G
A
L
L
I
C
D
I
Q
G
V
N
A
NNKF
Y
L
T
D
P
A
L
H
H
-----
I
D
Q
-----
N
--
K
FI
Y
S
E
T
N
L
G
E
V
G
I
S
Q
F
F
R
T
H
Q
C
N
A
I
C
Q
G
L
H
L
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
52.36
28%
-21
- C1 -
-
4NL0
1
?
A:
[62-265]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
F
A
K
G
G
E
R
L
A
F
R
A
I
N
G
------
R
--------------------------------------------------------------------
G
D
R
I
V
L
K
R
F
F
Q
-
Q
R
P
---
L
--
T
----------
M
-----------
L
L
E
T
I
E
R
Q
L
I
C
I
Y
L
A
N
I
F
N
K
L
N
V
S
---
P
N
K
L
H
F
L
P
N
Y
L
F
I
P
S
PTKDLD
G
K
I
L
T
L
-----
E
-------------
Q
T
E
Q
A
V
A
A
T
C
R
------
T
-----
P
-----
N
F
V
---
E
P
Y
L
S
G
Y
F
I
K
Y
I
D
N
N
G
W
I
---
N
E
---
S
E
F
H
S
T
L
H
A
F
A
H
W
T
W
V
H
T
K
G
A
L
L
I
C
D
I
Q
G
V
N
A
NNKF
Y
L
T
D
P
A
L
H
H
-----
I
D
Q
-----
N
--
K
FI
Y
S
E
T
N
L
G
E
V
G
I
S
Q
F
F
R
T
H
Q
C
N
A
I
C
Q
G
L
H
L
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
46.99
15%
-220
- C- -
-
2D1L
-
MTSS1_MOUSE
A:
[175-201]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
Y
L
L
L
E
E
T
E
K
Q
A
V
R
K
A
L
I
E
E
R
G
R
F
C
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------