@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_25_1580: (2018-03-10 )
MNPSSKRHAYEPLPQQQQQQHPTNPPPAYQHHRVSTGTGRESPALPQLSPNSMSAVTNIAEPSSSPALISTSAASSNLVPIFQGREDSAAASRRGGDGNSEVHPHPAEVSETYPGASTAAAQSMALAVVPFTGTSGVGVGVSAPQRCDPRVGGADQEGKNTGVGGDDVGYYSGPSPYGKLAPLSLSTERVCPHCLRPYDVFDDGEGVFDPATFFRVDATTRSSSIQPSPSHPKLLPPPSHEGDEQQKQQPSTSPRLYTEGAGDGGAAAGQLLCSRSSTAAGLDDSSSDGTNRSGNYITAVHPPAAAFTSHYFRALPPPSFIIAAGARGASAPLAIEDYRPSPLIGSPRDEKVEARQPFALAPALASDNGGGGGNSSGTLVCKVAAVPHYSYVWPITCTGMRSQVRLLQQGDSSEKTAAEMEGGKEESPSCESGSPVCSPTAATPSPNNGYYRHYFKELRQLGRGTYGGVYLCRHVMCGVNLGEFALKKIPVGDKVTYLQSVLREVRILEEVRRHPNVVEYKHSWVEEAQLADFGPPVRCLFILMEYASAGSLDTYLERYGNNLSTLAVWYFFLSSVAGTAHLHEKHILHRDLKPQNLLLAATKDRPPRVLVSDFGTAALLDDILYDRSGGTGTLEYMAPELLETTASPRGANERYVNHHTMASDVWSLGMVLHYLAFDGALPERHEDGSVNLDKARHSANARPPEMLRLLEAMLQLDPAKRPRCCDILASPMVQSIMRIFNKDDHSQWDLSIQRQQQLSATSPSAILPLERPPRPPVPAPAPRSAPLNALEAHSIDDSSSPRGARSRNAIAAISTSSQGRGVRADSTNLEDKSNTLQSSRVELLSASTLVDLSTAMARAGSSSSSNGSPLAMKLPPPRPSTVISQHGRQQQQRAHVVAGLPKTLASSNTFQFSDSPSPRRVNVGVQTNPVVIVEKQQRHA
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420....-----...430.......440....---------...450........460.......470..--.....480.-......490..-------...--..500.---......510-----........520.......530.......540.......550......--.560--.-.......570.......580.......590.......600...---------....610......-.620......---.630.---......640.......650.......660.......670....-----...----680--------.......690-.---....---------------------------------.--------.------..700----.--------.....----.710.......720.------......730....--...740.......750.......760.--......770.......780.......790.......800.......810.......820.......830.......840....---...850.......860.......870.......880.......890.......900.......910.......920.......930.......940
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MNPSSKRHAYEPL
P
Q
Q
Q
Q
QQHPTNPPPAY
Q
H
H
RVSTGTGRESPALPQLSPN
S
M
S
A
V
T
NIAEPSSS
P
A
L
I
S
TSAASSN
L
V
P
I
FQGREDSAAASRRGGDGNSEVHPHP
A
E
V
SETYPGA
S
T
AAA
Q
S
M
A
L
A
V
V
PFTGTSGVGVGVSAPQRCDPRVGGADQEGKNTGVGGDDVGYYSGPSPYGKLAPLSLSTERV
C
P
H
CLRPYDVFDDGEGVFDP
A
T
F
F
R
V
D
ATTRSSSIQPSPSHPKLLPPPSHEG
D
E
Q
Q
KQQPSTSP
R
L
Y
TEGAGDG
G
A
A
A
G
Q
L
LCSRSSTAAGLDDSSSDGTNRSG
N
Y
I
T
A
VHP
P
A
A
A
F
T
S
H
Y
F
RALPPP
S
F
I
I
A
AGARGASA
P
L
A
I
EDYRPSPLIGSPRDEKVEARQP
F
A
LA
P
A
LASDNGGGGGNSS
G
T
L
V
C
K
V
AAVPH
Y
S
Y
V
W
P
I
TCTG
M
R
S
Q
V
R
L
L
QQGDSSEK
T
A
A
E
MEGGKEE-----SPSCESGSPVCSPTAATPSP---------NN
G
Y
Y
-
R
H
Y
F
K
E
L
R
Q
LGRGTY
G
G
V
Y
L
C
R
H
--
V
M
CGV
N
L
G
E
-
F
A
L
K
KIPVGD
K
-------
V
T
Y
--
L
Q
S
V
L
R
---
E
V
R
I
L
E
E
V
------
R
RHP
N
V
V
E
Y
K
H
S
W
V
E
E
A
QLADFG
P
P
V
R
C
L
F
I
L
M
E
Y
ASAG
S
L
D
T
Y
L
E
R
--YGN---N-
L
S
T
L
A
V
W
Y
F
F
L
S
S
VAGT
A
H
L
H
E
K
H
I
L
HRDLKPQ
N
L
L
L
A
ATKDR---------PP
R
V
L
V
S
DFG
T
A
A
-
L
L
D
D
I
L
YDRS---GGTG
T
---
L
E
Y
M
A
P
E
L
L
E
TTASPRGANE
R
Y
VN
H
H
T
M
A
S
D
V
W
S
L
G
M
V
L
H
Y
L
A-----FDG----ALP--------ERHEDGSV---
N
---
L
D
K
A
---------------------------------R--------H------SANAR----
P
--------
P
E
M
L
R
----
L
L
E
A
M
L
QLDPAKR
P
R
------
C
C
D
I
L
A
S
P
M
V
Q
S
I
--
M
R
I
FNKDDHSQW
D
L
S
I
Q
R
Q
Q
QLSATSP--S
A
I
LPLERPPRPPVPAPAPRSAPLN
A
L
EAHSIDDSSSPRGARSR
N
A
I
A
A
I
STSSQGRGVRADSTNLEDKSN
T
L
Q
S
S
R
V
E
L
LSA---
S
T
L
V
D
L
S
T
A
M
A
RAGSSSSSNGS
P
L
A
M
KLPPPR
P
S
T
V
I
S
QH
G
R
Q
Q
Q
Q
R
A
H
V
VAG
L
P
K
T
LASSN
T
F
QFSDSPSP
R
R
V
N
V
GVQTN
P
V
V
I
V
EKQQRHA
28
HHSearch
67.85
26%
-93
- C1 -
-
4XBR
1
INKA1_HUMAN (first)
A:
[94-350]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
--
R
S
S
G
---
K
L
-
V
A
V
K
K
M
D
L
R
K
Q
--------
Q
R
--
R
E
L
L
F
N
---
E
V
V
I
M
R
D
Y
-------
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
----------
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
--
T
-----
R
-
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
-------------
G
R
V
K
L
S
D
F
G
F
C
A
-
Q
V
S
K
E
V
P
R
R
K
---
S
L
V
G
T
---
P
Y
W
M
A
P
E
L
I
S
R
L
------------
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
-----
D
-
G
----
E
P
P
--------
Y
F
N
E
P
P
L
K
---
A
---
M
K
M
I
---------------------------------
R
DNLPPRL-
K
------
N
L
H
K
V
----
S
--------
P
S
L
K
G
----
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
------
A
A
E
L
L
K
H
P
F
L
A
K
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
66.53
28%
-94
- C1 -
-
5J5T
1
M4K3_HUMAN
A:
[4-268]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
F
E
L
I
Q
R
I
G
S
G
T
Y
G
D
V
Y
K
A
R
N
--
V
N
T
G
E
---
L
-
A
A
I
K
V
I
K
L
E
P
G
--------
E
D
--
F
A
V
V
Q
Q
---
E
I
I
M
M
K
D
C
-------
K
H
P
N
I
V
A
Y
F
G
S
Y
L
R
R
----------
D
K
L
W
I
C
M
E
F
C
G
G
G
S
L
Q
D
I
Y
H
V
--
T
G
----
P
-
L
S
E
L
Q
I
A
Y
V
S
R
E
T
L
Q
G
L
Y
Y
L
H
S
K
G
K
M
H
R
D
I
K
G
A
N
I
L
L
T
D
N
-------------
G
H
V
K
L
A
D
F
G
V
S
A
-
Q
I
T
A
T
I
A
------
A
F
I
G
T
---
P
Y
W
M
A
P
E
V
A
A
V
E
R
K
---------
G
G
Y
N
Q
L
C
D
L
W
A
V
G
I
T
A
I
E
L
A
-----
E
-
L
----
Q
P
P
--------
M
F
D
L
H
P
M
R
---
A
L
--
F
L
M
T
---------------------------------
K
S
N
F
Q
P
P
KL
K
------
D
K
M
K
W
----
S
--------
N
S
F
H
H
----
F
V
K
M
A
L
T
K
N
P
K
K
R
P
T
------
A
E
K
L
L
Q
H
P
F
V
T
Q
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
Fugue
65.17
18%
-2
- C1 -
-
2ACX
1
GRK6_HUMAN
A:
[14-532]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
R
K
G
K
S
K
K
W
R
Q
M
L
Q
F
P
H
I
S
Q
C
E
E
L
R
L
S
L
E
R
D
--
Y
H
S
L
C
E
R
N
P
I
G
R
L
L
F
R
E
F
C
A
T
------
R
P
E
L
S
R
C
V
A
F
L
D
G
V
A
E
Y
E
V
T
P
D
D
K
R
K
A
C
G
R
N
L
T
Q
N
F
L
S
H
T
G
P
D
L
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
E
Q
G
P
C
K
D
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
---------
R
Q
P
V
T
-
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
--
R
A
T
G
---
K
M
-
Y
A
C
K
K
L
E
K
K
R
I
-------
K
K
R
KG
E
A
M
A
L
N
---
E
K
Q
I
L
E
K
V
------
N
-
S
R
F
V
V
S
L
A
Y
A
Y
E
T
K
----------
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
--
M
G
Q
---
A
G
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
E
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
----
D
D
---------
H
G
H
I
R
I
S
D
L
G
L
A
V
-
H
V
P
E
-
G
Q
T
I
K
---
G
R
V
G
T
---
V
G
Y
M
A
P
E
V
V
K
--------
N
E
R
Y
----
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
-----
A
-
G
----
Q
S
P
--------
F
Q
Q
R
K
K
K
I
---
K
---
R
E
E
V
---------------------------------
E
--------
R
------
L
V
K
E
V
----
P
E
E
Y
S
ERFS
P
Q
A
R
S
----
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
------
C
R
G
G
S
A
R
E
V
K
E
----
H
P
L
F
K
K
L
N
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
D
P
Q
A
--
I
Y
C
E
P
T
D
Q
D
F
Y
Q
K
F
A
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
E
C
F
Q
E
L
N
V
F
G
L
D
G
S
----------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
61.30
25%
-106
- C1 -
-
2QR8
-
A:
[20-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
-
T
D
G
Y
E
V
K
E
D
I
G
V
G
S
Y
S
V
C
K
R
C
I
H
--
K
A
T
N
---
M
E
-
F
A
V
K
I
I
D
K
S
K
--------------
R
D
P
T
E
---
E
I
E
I
L
L
R
Y
------
G
Q
H
P
N
I
I
T
L
K
D
V
Y
D
D
G
----------
K
Y
V
Y
V
V
T
E
L
M
K
G
G
E
L
L
D
K
I
L
R
--
Q
K
----
F
-
F
S
E
R
E
A
S
A
V
L
F
T
I
T
K
T
V
E
Y
L
H
A
Q
G
V
V
H
R
D
L
K
P
S
N
I
L
Y
V
D
E
S
G
N
---------
P
E
S
I
R
I
C
D
F
G
F
A
K
-
Q
L
R
A
E
N
G
L
L
M
---
T
P
C
Y
T
---
A
N
F
V
A
P
E
V
L
E
R
Q
------------
G
Y
D
A
A
C
D
I
W
S
L
G
V
L
L
Y
T
M
L
-----
T
-
G
----
Y
T
P
--------
F
A
N
G
P
D
D
T
---
P
E
E
I
L
A
R
I
---------------------------------
G
S
GKFSLSG
G
------
Y
W
N
S
V
----
S
--------
D
T
A
K
D
----
L
V
S
K
M
L
H
V
D
P
H
Q
R
L
T
------
A
A
L
V
L
R
H
P
W
I
V
H
W
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
HHSearch
60.86
26%
-96
- C1 -
-
1KOB
1
?
A:
[51-312]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
Y
D
I
L
E
E
L
G
S
G
A
F
G
V
V
H
R
C
V
E
--
K
A
T
G
R
---
V
-
F
V
A
K
F
I
N
T
P
Y
P
--------
L
D
--
K
Y
T
V
K
N
---
E
I
S
I
M
N
Q
L
-------
H
H
P
K
L
I
N
L
H
D
A
F
E
D
K
----------
Y
E
M
V
L
I
L
E
F
L
S
G
G
E
L
F
D
R
I
A
A
--
E
D
Y
---
K
-
M
S
E
A
E
V
I
N
Y
M
R
Q
A
C
E
G
L
K
H
M
H
E
H
S
I
V
H
L
D
I
K
P
E
N
I
M
C
E
T
K
K
-----------
A
S
S
V
K
I
I
D
F
G
L
A
T
-
K
L
N
P
D
E
I
-
V
K
---
V
T
T
A
T
---
A
E
F
A
A
P
E
I
V
D
R
E
P
------------
V
G
F
Y
T
D
M
W
A
I
G
V
L
G
Y
V
L
L
-----
S
-
G
----
L
S
P
--------
F
A
G
E
D
D
L
E
---
T
---
L
Q
N
V
K
R
C
D
W
E
F
D-------------------------
E
--------
D
------
A
F
S
S
V
----
S
--------
P
E
A
K
D
----
F
I
K
N
L
L
Q
K
E
P
R
K
R
L
T
------
V
H
D
A
L
E
H
P
W
L
K
G
D
--
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
Fugue
60.42
22%
-31
- C1 -
-
2RIO
1
IRE1_YEAST
A:
[8-434]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
---------
F
E
Q
S
L
-
K
N
L
V
V
S
E
K
I
L
G
Y
G
S
S
G
T
V
V
F
Q
G
S
--
F
----
Q
G
R
P
-
V
A
V
K
R
M
L
-----------
I
D
F
--
C
D
I
A
L
M
---
E
I
K
L
L
T
E
S
------
D
D
H
P
N
V
I
R
Y
Y
C
S
E
T
T
D
----------
R
F
L
Y
I
A
L
E
L
C
N
-
L
N
L
Q
D
L
V
E
------------
S
K
Y
N
P
I
S
L
L
R
Q
I
A
S
G
V
A
H
L
H
S
L
K
I
I
H
R
D
L
K
P
Q
N
I
L
V
S
T
S
S
R
F
TADQQTGAE
N
L
R
I
L
I
S
D
F
G
L
C
K
-
K
L
D
-------------
S
T
---
S
G
W
R
A
P
E
L
L
E
E
S
N
N
L
Q
T
K
R
-----
R
L
T
R
S
I
D
I
F
S
M
G
C
V
F
Y
Y
I
L
-----
S
K
G
----
K
H
P
FGDKYS
R
E
S
N
I
I
R
G
I
F
---
S
---
L
D
E
M
---------------------------------
K
--------
C
L-----
H
D
R
S
L
----
I
--------
A
E
A
T
D
----
L
I
S
Q
M
I
D
H
D
P
L
K
R
P
T
------
A
M
K
V
L
R
H
P
L
F
--------
W
P
K
S
K
K
L
E
F
L
L
K
V
S
D
R
L
E
I
E
N
R
D
P
PS
A
L
L
M
K
F
D
A
G
S
D
F
V
I
P
S
G
D
W
T
V
K
F
D
K
T
F
M
------
D
R
K
Y
H
S
S
K
L
M
D
L
L
R
A
L
R
N
K
Y
H
H
--
F
M
D
L
P
E
D
I
A
E
L
M
G
P
V
P
D
G
F
Y
D
Y
F
T
K
R
FP
N
L
L
I
G
V
Y
M
I
V
K
E
N
L
S
D
D
Q
I
L
R
E
F
L
Y
S
--------------------------------------------------------------------
49
Fugue
53.81
18%
-62
- C1 -
-
1TKI
-
TITIN_HUMAN
A:
[18-338]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
L
-
Y
E
K
Y
M
I
A
E
D
L
G
R
G
E
F
G
I
V
H
R
C
V
E
--
T
S
S
K
---
K
T
-
Y
M
A
K
F
V
K
V
K
G
---------
T
D
--
Q
V
L
V
K
K
---
E
I
S
I
L
N
I
A
------
R
-
H
R
N
I
L
H
L
H
E
S
F
E
S
M
----------
E
E
L
V
M
I
F
E
F
I
S
G
L
D
I
F
E
R
I
N
T
--
S
A
F
---
E
-
L
N
E
R
E
I
V
S
Y
V
H
Q
V
C
E
A
L
Q
F
L
H
S
H
N
I
G
H
F
D
I
R
P
E
N
I
I
Y
--
Q
T
R
R
---------
S
S
T
I
K
I
I
E
F
G
Q
A
R
-
Q
L
K
P
-
G
D
N
F
R
---
L
L
F
T
A
---
P
E
Y
Y
A
P
E
V
H
Q
H
------------
D
V
V
S
T
A
T
D
M
W
S
L
G
T
L
V
-
Y
V
L
-----
L
S
G
----
I
N
P
--------
F
L
A
E
T
N
Q
Q
---
I
---
I
E
N
I
---------------------------------
M
N
AEYTFDE
E
------
A
F
K
E
I
----
S
--------
I
E
A
M
D
----
F
V
D
R
L
L
V
K
E
R
K
S
R
M
T
------
A
S
E
A
L
Q
H
P
W
L
K
Q
K
--
I
E
R
V
S
T
K
V
I
R
T
-
L
K
H
R
R
Y
Y
H
T
L
I
K
K
D
L
--
N
M
V
V
S
A
A
R
I
S
C
G
G
A
I
R
S
Q
K
G
V
S
V
A
K
V
K
V
A
S
I
-----------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
52.86
28%
0
- C- -
-
2WEL
7
KCC2D_HUMAN
A:
[4-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
--
I
P
T
G
---
Q
E
-
Y
A
A
K
I
I
N
T
K
K
L
S------
A
R
D
--
H
Q
K
L
E
R
---
E
A
R
I
C
R
L
L
-------
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
----------
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
--
R
E
----
Y
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
-
K
---------
G
A
A
V
K
L
A
D
F
G
L
A
I
-
E
V
Q
G
D
Q
Q
A
W
F
---
G
F
A
G
T
---
P
G
Y
L
S
P
E
V
L
R
K
D
------------
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
-----
V
-
G
----
Y
P
P
--------
F
W
D
E
D
Q
H
R
---
L
---
Y
Q
Q
I
K
A
GAYDFP-------------------------
S
--------
P
------
E
W
D
T
V
----
T
--------
P
E
A
K
D
----
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
------
A
S
E
A
L
K
H
P
W
I
C
Q
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
52.62
27%
16
- C1 -
-
4B4L
3
DAPK1_HUMAN
A:
[12-280]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
--
K
S
T
G
L
---
Q
-
Y
A
A
K
F
I
K
K
R
R
T
KSSRR--
G
V
S
--
R
E
D
I
E
R
---
E
V
S
I
L
K
E
I
-------
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
----------
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
--
K
E
----
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
---------
K
P
R
I
K
I
I
D
F
G
L
A
H
-
K
I
D
F
G
N
-
E
F
K
---
N
I
F
G
T
---
P
E
F
V
A
P
E
I
V
N
Y
E
------------
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
-----
S
-
G
----
A
S
P
--------
F
L
G
D
T
K
Q
E
---
T
---
L
A
N
V
S
A
VNYEFE-------------------------
D
--------
E
------
Y
F
S
N
T
----
S
--------
A
L
A
K
D
----
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
------
I
Q
D
S
L
Q
H
P
W
I
K
P
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
51.59
27%
19
- C1 -
-
2X0G
-
DAPK1_HUMAN
A:
[10-278]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
--
K
S
T
G
L
---
Q
-
Y
A
A
K
F
I
K
K
R
R
T
KSSRR--
G
V
S
--
R
E
D
I
E
R
---
E
V
S
I
L
K
E
I
-------
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
----------
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
--
K
E
----
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
---------
K
P
R
I
K
I
I
D
F
G
L
A
H
-
K
I
D
F
G
N
-
E
F
K
---
N
I
F
G
T
---
P
E
F
V
A
P
E
I
V
N
Y
E
------------
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
-----
S
-
G
----
A
S
P
--------
F
L
G
D
T
K
Q
E
---
T
---
L
A
N
V
S
A
VNYEFE-------------------------
D
--------
E
------
Y
F
S
N
T
----
S
--------
A
L
A
K
D
----
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
------
I
Q
D
S
L
Q
H
P
W
I
K
P
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
50.90
20%
-89
- C1 -
-
1TKI
-
TITIN_HUMAN
A:
[22-283]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
Y
M
I
A
E
D
L
G
R
G
E
F
G
I
V
H
R
C
V
E
--
T
S
S
K
K
---
T
-
Y
M
A
K
F
V
K
V
K
G
T
---------
D
--
Q
V
L
V
K
K
---
E
I
S
I
L
N
I
A
-------
R
H
R
N
I
L
H
L
H
E
S
F
E
S
M
----------
E
E
L
V
M
I
F
E
F
I
S
G
L
D
I
F
E
R
I
N
T
--
S
A
F
---
E
-
L
N
E
R
E
I
V
S
Y
V
H
Q
V
C
E
A
L
Q
F
L
H
S
H
N
I
G
H
F
D
I
R
P
E
N
I
I
Y
Q
T
R
R
-----------
S
S
T
I
K
I
I
E
F
G
Q
A
R
-
Q
L
K
P
G
D
-
N
F
R
---
L
L
F
T
A
---
P
E
Y
Y
A
P
E
V
H
Q
H
D
------------
V
V
S
T
A
T
D
M
W
S
L
G
T
L
V
Y
V
L
L
-----
S
-
G
----
I
N
P
--------
F
L
A
E
T
N
Q
Q
---
I
---
I
E
N
I
M
N
AEYTFD-------------------------
E
--------
E
------
A
F
K
E
I
----
S
--------
I
E
A
M
D
----
F
V
D
R
L
L
V
K
E
R
K
S
R
M
T
------
A
S
E
A
L
Q
H
P
W
L
K
Q
K
--
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
Fugue
50.37
18%
-45
- C1 -
-
4XHG
2
?
A:
[2-397]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
R
V
-
G
R
K
F
R
I
G
R
K
I
G
S
G
S
F
G
D
I
Y
H
G
T
N
--
L
I
S
G
---
E
E
-
V
A
I
R
L
E
S
I
R
S
R
-------
H
P
Q
--
L
D
Y
E
S
R
---
V
Y
K
Y
L
S
G
G
------
V
G
I
P
F
I
R
W
F
G
R
E
G
E
Y
N
A
M
V
I
D
L
L
G
P
--------------
S
L
E
D
L
F
N
Y
--
C
H
R
---
K
-
F
S
F
K
T
V
I
M
L
A
L
Q
M
I
C
R
V
Q
Y
I
H
G
R
S
F
I
H
R
D
I
K
P
D
N
F
L
M
G
-
V
G
R
R
---------
G
S
T
V
H
V
I
D
F
G
L
S
------
K
K
Y
R
D
F
---
N
T
H
R
H
---
I
P
Y
R
E
N
K
S
L
T
G
T
A
R
Y
A
S
V
N
T
H
L
G
I
E
Q
S
R
R
D
D
L
E
S
L
G
Y
M
L
I
Y
F
C
KGSLP
W
Q
G
LK--
A
T
T
--------
K
K
Q
K
Y
D
R
I
---
L
---
E
K
K
L
---------------------------------
C
--------
I
------
S
V
E
T
L
C
AGL
P
--------
L
E
F
S
E
----
Y
M
N
Y
C
R
N
L
K
F
D
E
R
P
D
-------
Y
L
Y
L
A
R
L
F
K
D
L
S
--
I
K
L
E
Y
H
N
D
H
L
-
F
D
W
T
M
L
R
Y
T
K
A
M
V
E
K
K
--
N
D
S
F
N
K
V
K
L
L
A
M
K
K
F
A
S
H
F
H
Y
C
K
N
D
D
K
H
Y
P
T
P
E
E
I
K
Q
Q
T
V
Q
N
N
N
A
A
P
E
L
L
S
A
I
D
K
-----------------------------------------------------------------------------------------------------------------------------
25
HHSearch
49.92
23%
-96
- C1 -
-
2X4F
4
MYLK4_HUMAN
A:
[90-349]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
S
K
T
E
I
L
G
-----
Q
V
H
K
C
E
E
--
T
A
T
G
L
---
K
-
L
A
A
K
I
I
K
T
R
G
M
--------
K
D
--
K
E
E
V
K
N
---
E
I
S
V
M
N
Q
L
-------
D
H
A
N
L
I
Q
L
Y
D
A
F
E
S
K
----------
N
D
I
V
L
V
M
E
Y
V
D
G
G
E
L
F
D
R
I
I
D
--
E
S
Y
---
N
-
L
T
E
L
D
T
I
L
F
M
K
Q
I
C
E
G
I
R
H
M
H
Q
M
Y
I
L
H
L
D
L
K
P
E
N
I
L
C
V
N
R
D
-----------
A
K
Q
I
K
I
I
D
F
G
L
A
R
-
R
Y
K
P
R
E
-
K
L
K
---
V
N
F
G
T
---
P
E
F
L
A
P
E
V
V
N
Y
D
------------
F
V
S
F
P
T
D
M
W
S
V
G
V
I
A
Y
M
L
L
-----
S
-
G
----
L
S
P
--------
F
L
G
D
N
D
A
E
---
T
---
L
N
N
I
L
A
CRWDLE-------------------------
D
--------
E
------
E
F
Q
D
I
----
S
--------
E
E
A
K
E
----
F
I
S
K
L
L
I
K
E
K
S
W
R
I
S
------
A
S
E
A
L
K
H
P
W
L
S
D
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
Fugue
49.54
27%
-11
- C1 -
-
1BYG
1
CSK_HUMAN
A:
[15-276]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
W
A
L
N
M
K
E
L
K
L
L
Q
T
I
G
K
G
E
F
G
D
V
M
L
G
D
Y
RG-------
N
K
-
V
A
V
K
C
I
K
------------
N
D
--
A
Q
A
F
L
A
---
E
A
S
V
M
T
Q
L
-------
R
H
S
N
L
V
Q
L
L
G
V
I
V
--------
E
E
G
---
L
Y
I
V
T
E
Y
M
A
K
G
S
L
V
D
Y
L
R
S
R
G-
R
S
---
V
-
L
G
G
D
C
L
L
K
F
S
L
D
V
C
E
A
M
E
Y
L
E
G
N
N
F
V
H
R
D
L
A
A
R
N
V
L
V
----
S
E
---------
D
N
V
A
K
V
S
D
F
G
----------------------LLP
V
K
W
T
A
P
E
A
L
R
E
------------
K
K
F
S
T
K
S
D
V
W
S
F
G
I
L
L
W
E
I
Y
-----
S
F
G
----
R
V
P
--------
Y
P
R
I
P
L
-
K
---
D
---
V
V
P
R
---------------------------------
V
--------
E
K
G
Y
K
M
D
A
P
D
G
C
----
P
--------
P
A
V
Y
E
----
V
M
K
N
C
W
H
L
D
A
A
M
R
P
S
-----------
F
L
Q
L
R
E
Q
L
--
E
H
I
K
T
H
E
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
49.36
24%
-89
- C1 -
-
4NIF
-
KS6A1_HUMAN
A:
[6-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
-
S
D
G
Y
V
V
K
E
T
I
G
V
G
S
Y
S
E
C
K
R
C
V
H
--
K
A
T
N
M
---
E
-
Y
A
V
K
V
I
D
K
S
K
--------------
R
D
P
S
E
---
E
I
E
I
L
L
R
Y
------
G
Q
H
P
N
I
I
T
L
K
D
V
Y
D
D
G
----------
K
H
V
Y
L
V
T
E
L
M
R
G
G
E
L
L
D
K
I
L
R
--
Q
K
----
F
-
F
S
E
R
E
A
S
F
V
L
H
T
I
G
K
T
V
E
Y
L
H
S
Q
G
V
V
H
R
D
L
K
P
S
N
I
L
Y
V
D
E
S
G
N
---------
P
E
C
L
R
I
C
D
F
G
F
A
K
-
Q
L
R
A
E
N
G
L
L
M
---
T
P
C
Y
------
F
V
A
P
E
V
L
K
R
Q
------------
G
Y
D
E
G
C
D
I
W
S
L
G
I
L
L
Y
T
M
L
-----
A
-
G
----
Y
T
P
--------
F
A
N
G
P
S
D
T
P
E
E
I
---
L
T
R
I
---------------------------------
G
S
GKFTLSG
G
------
N
W
N
T
V
----
S
--------
E
T
A
K
D
----
L
V
S
K
M
L
H
V
D
P
H
Q
R
L
T
------
A
K
Q
V
L
Q
H
P
W
V
T
Q
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
Fugue
48.39
19%
12
- C1 -
-
4AW2
5
MRCKA_RAT
A:
[1-416]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
E
V
R
L
R
Q
L
E
Q
F
I
L
D
G
P
A
Q
T
N
G
Q
C
F
-----
S
V
E
T
L
L
D
I
L
I
C
L
Y
D
E
C
N
N
S
P
LRRE
K
N
I
L
E
Y
L
E
W
A
-
K
P
F
T
S
K
V
K
Q
M
R
L
--
H
R
E
D
F
E
I
L
K
--
V
I
G
R
G
A
F
G
E
-
V
A
V
V
K
L
K
N
A
D
K
--------
V
F
--
A
M
K
I
L
N
---
K
W
E
M
L
K
R
A
ETAC
F
R
E
E
R
D
V
L
V
N
G
D
S
K
W
I
T
T
L
H
Y
A
F
Q
D
D
--
N
N
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
--
F
E
D
---
R
-
L
P
E
E
M
A
R
F
Y
L
A
E
M
V
I
A
I
D
S
V
H
Q
L
H
Y
V
H
R
D
I
K
P
D
N
I
L
M
----
D
M
---------
N
G
H
I
R
L
A
D
F
G
S
C
L
K
L
M
E
D
G
T
V
Q
S
S
---
V
A
V
G
T
---
P
D
Y
I
S
P
E
I
L
Q
A
M
E
G
G
K
G
-------
R
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
-----
Y
G
E
TPFY
A
E
S
--------
L
V
E
T
Y
G
K
I
---
M
---
N
H
K
E
---------------------------------
R
--------
F
------
Q
F
P
T
Q
----
V
--------
T
D
V
S
E
----
N
A
K
D
L
I
R
R
L
I
C
S
R
E
H
RLGQNG
I
E
D
F
K
K
H
P
F
F
S
G
I
DW
D
N
I
R
N
C
E
A
P
Y
I
P
E
V
S
S
P
T
D
T
S
N
F
D
V
D
S
--
G
H
H
L
P
F
V
G
F
T
Y
T
S
S
C
V
L
S
D
R
S
C
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
48.33
27%
-29
* C1 *
-
2Y7J
1
PHKG2_HUMAN
C:
[93-364]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
--
R
A
T
G
H
---
E
-
F
A
V
K
I
M
E
V
T
A
E
RLSPEQL
E
E
V
--
R
E
A
T
R
R
---
E
T
H
I
L
R
Q
V
------
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
----------
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
--
K
V
----
A
-
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
D
D
N
-------------
M
Q
I
R
L
S
D
F
G
F
S
C
-
H
L
E
P
G
E
-
K
L
R
---
E
L
C
G
T
---
P
G
Y
L
A
P
E
I
L
K
C
S
M
D
E
------
T
H
P
G
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
-----
A
-
G
----
S
P
P
--------
F
W
H
R
R
Q
I
L
---
M
---
L
R
M
I
---------------------------------
M
EGQYQFSS
P
------
E
W
D
D
R
----
S
--------
S
T
V
K
D
----
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
------
A
E
Q
A
L
Q
H
P
F
F
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
47.97
32%
-4
- C1 -
-
4L42
1
KS6B1_HUMAN
A:
[20-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
--
V
-
T
G
A
N
T
G
K
I
F
A
M
K
V
L
K
K
A
M
I
-------
V
R
N
--
A
K
D
T
A
H
T
K
A
E
R
N
I
L
E
E
V
------
K
-
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
----------
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
--
E
G
I
---
F
-
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
-
L
G
H
L
H
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
----
N
H
---------
Q
G
H
V
K
L
T
D
F
G
----
L
C
K
E
S
I
H
D
G
T
VTH
T
F
C
G
T
---
I
E
Y
M
A
P
E
I
L
M
R
S
G
------------
H
N
R
A
V
D
W
W
S
L
G
-
A
L
M
Y
D
M
-----
L
T
G
----
A
P
P
--------
F
T
G
E
N
R
K
K
---
T
---
I
D
K
I
---------------------------------
L
--------
K
------
C
K
L
N
L
----
P
--------
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
47.88
24%
-43
- C1 -
-
3C0G
1
CSKP_HUMAN
B:
[22-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
-
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
--
R
E
T
G
---
Q
Q
-
F
A
V
K
I
V
D
V
A
K
F
T
S
SP---
G
L
S
--
T
E
D
L
K
R
---
E
A
S
I
C
H
M
L
-------
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
----------
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
--
R
A
D
A
G
F
V
-
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
E
-
N
---------
S
A
P
V
K
L
G
G
F
G
V
A
I
-
Q
L
G
E
S
G
L
V
A
G
---
G
R
V
G
T
---
P
H
F
M
A
P
E
V
V
K
R
E
------------
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
-----
S
-
G
----
C
L
P
--------
F
Y
G
T
K
E
R
L
---
F
---
E
G
I
I
---------------------------------
K
GKYKMNP-
R
------
Q
W
S
H
I
----
S
--------
E
S
A
K
D
----
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
------
V
Y
E
A
L
N
H
P
W
L
K
E
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
47.65
24%
-52
- C1 -
-
1J1B
1
GSK3B_HUMAN
B:
[54-344]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
--
C
D
S
G
E
---
L
-
V
A
I
K
K
V
L
Q
D
K
--------------
R
F
K
N
R
---
E
L
Q
I
M
R
K
L
-------
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
E
K
----
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
---
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
------------
A
V
L
K
L
C
D
F
G
S
A
K
-
Q
L
V
R
G
E
-
P
N
V
---
S
Y
I
C
S
---
R
Y
Y
R
A
P
E
L
I
F
G
A
T
-----------
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
-----
L
-
G
----
Q
P
I
--------
F
P
G
D
S
G
V
D
---
Q
---
L
V
E
I
I
K
V
LGTPT
R
E
Q
I
R
E
M
NPNYTEFKFPQIKAHP
W
T
K
--------
V
------
F
R
P
R
T
----
P
--------
P
E
A
I
A
----
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
------
P
L
E
A
C
A
H
S
F
F
D
E
L
--
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------