@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_25_1620: (2018-03-10 )
MVQTLYVDPTLSSAAVTSHSSYYATPVSQGGGNDDEGQAHRLCERAGGPATHASAHSVALTQSSSCTCRSRASSQSNWPTPPPPLPHAAPSSSSSVSSSYSDEDVEDETNEKDPRNYAEDVTKKYPIFTEAYAEKFRRDATPFMRVVEAASAMSRTSSPTGSVSGPPQQEKQFVLYDTYLYERTLGKGTFSKVVLGIAPPSSPALATQISGDVPARVALKVFRDKEEYIEACWDEFTILNSICVDPPSVAPEEVAAAAAAGHRQGTTTSSPYISVRSVVMFTASTCGIKQQYFADQGRFLVPMGYVAHPVHPAIVFPVMGPTLLNVLNTIRQKSKEVTRASRHKRLRTEAQSGKSTCSDGAFSTMPRQFSATAVTVDMGASGDAQQPLPPLTQEQPQQQQQRRRRVYYRGLPLPLLKAVLYQVLTFLQFIHCRGVVHTDLKPENVLFESSKVLSVDVGIYYTHYLRRNSDTVAKRMPSAAETKKRSNDDCKLHSSSLEQRAHRHEQMAFTLSSPPPSSNRSVAAVTGAAAEGEGLKAGPMEAARSAGEGAASMSSTGLSIVPVDVTPSQKGDLTLAHYVRVPMPVMNSVRVVDLGAAQFLSTFRDHSLIPGYAHVPVSYNPIQTSHYRSPEVLLGFGWNTSADIFSLGCMIPELLTGECLFMPNHTMEHLAMMQHVIGTFHDKDGIRSGTATNLRSVFACDMRTFRHYFTLQPNNRDFDLKWPVSKSMVHEQEKQQRFASAASGKTEDDGLEPLEETLPGDIDYVTRMPTLDDILAPLPDLLDLTRRMLCYHPFKRITAEEAMQHPFFRNI
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220...---------.------.-------..230.......240-.-......250.......260.......270.......280.......290.......300....------...310.......-320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420..----.....430-........440.......450...-....460.......470.......480.......490.......500..--.....510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630..------.-.-...640.......650.......660-----.......------.670-------------.......680---.........690.......700.......710----.........720.......730.......740.......750.......760.......770.......780.......790.......800.......810
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
V
Q
T
L
Y
VDPTLSSAAVTSHS
S
Y
Y
ATPVSQGGGNDD
E
G
Q
A
H
R
L
C
E
RAGGPATHASA
H
S
V
A
L
TQSSS
C
T
CRSRASSQSNWPTPPPPLPHAAPSSSSSVSSSYSDEDVEDETNEKD
P
R
N
Y
A
E
D
V
T
K
KYPI
F
T
E
A
Y
A
E
K
F
RRDA
T
P
F
M
R
V
V
E
A
A
S
A
M
SRTSSPTGSVSGP
P
Q
QE
K
Q
F
V
L
Y
D
T
Y
L
Y
E
RTLGKG
T
F
S
K
V
V
L
G
IAPPSSP
A
L
A
T
QISGDV
P
A
R
V
A
L
K
V
FR
D
K
---------
E
------
E
-------
Y
I
E
A
C
W
D
E
F
T
I
L
N
S
I-C-VDPPSV
A
P
E
E
V
A
A
A
A
AAGHRQGTTTSSP
Y
I
S
V
R
S
V
V
M
F
TASTCG
I
K
Q
Q
Y
FADQG
R
F
L
V
P
M
G
Y
V------AHPVH
P
A
I
V
FPVM-
G
P
T
L
L
N
V
L
N
T
I
R
Q
K
S
K
E
V
T
R
A
S
R
H
K
R
L
R
T
E
A
QSGKSTCSDGAFSTMPRQFS
A
T
A
V
T
V
DMGASGDAQQPLPPL
T
Q
E
Q
P
Q
Q
Q
Q
Q
R
R
R
R
V
Y
YRGL
P
L
P
L
L
K
A
V
L
Y
Q
V
L
----
T
F
L
Q
F
I
H
--CR
G
V
V
HTDLKPEN
V
L
FESS
K
V
L
S
V
-
D
V
G
I
Y
Y
T
H
Y
L
RRNS
D
T
V
A
K
RMP
S
A
A
ETKKRSNDDCKL
H
S
S
S
L
E
Q
R
A
H
R
H
--
E
Q
M
A
F
T
LSSPPPSSNR
S
V
A
A
V
TGAAAEGEGLKA
G
P
M
E
A
A
R
SAGEGAASMSSTG
L
S
I
V
P
VDVTPSQKG
D
L
T
L
A
H
Y
VRVPMPVMN
S
V
R
V
V
DL
G
A
A
Q
F
L
S
T
FRDHSLIPGYAHVPVSYNPIQTSHYRSP
E
V
L
L
------
G
-F-GWNTS
A
D
I
F
S
L
G
C
M
I
P
E
LLTG
E
C
L
F------MPN
H
T
M
E
------
H
L
A
M
-------------
M
Q
H
V
I
G
TF-----HDKDGIRSG
T
A
T
N
L
R
S
V
F
A
C
D
M
R
T
F
R
H
Y
F
T
------LQPNNRDF
D
L
KWP
V
S
K
S
M
V
H
E
Q
E
K
Q
Q
R
F
A
S
AASGKTEDDGL
E
P
L
E
E
TLPGD
I
D
Y
VTRMP
T
L
D
D
I
L
AP
L
P
D
L
L
D
L
T
R
R
M
L
C
Y
H
P
F
K
RI
T
A
E
E
A
M
QHPFFRNI
36
HHSearch
88.28
27%
-137
- C1 -
-
5LXC
8
DYRK2_HUMAN
A:
[69-297]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-----------
H
K
V
-
H
Q
H
V
A
L
K
M
V
R
N
E
---------
K
------
R
-------
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
-
R
-
K
Q
D
K
----------
D
N
T
M
N
V
--------------
I
H
M
----------------------
L
E
N
F
------
T
F
R
N
H
I
C
M
T
F
E
L
L
-
S
M
N
L
Y
E
L
I
K
K
-----------------------
N
-----------------------------------------------------
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
----
Q
C
L
D
A
L
H
--
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
K
Q
Q
G
-----------------------------------------------------------------------------------------------------------------------------------------
R
S
G
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
R
--------------
V
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
------
G
-
A
-
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
------
P
G
E
D
E
G
D
------
Q
L
A
C
-------------
M
I
E
L
L
G
M
P
----------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
87.72
28%
-147
* C1 *
-
4AZF
1
DYRK2_HUMAN
A:
[93-319]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-----------
H
K
V
-
H
Q
H
V
A
L
K
M
V
R
N
E
---------
K
------
R
-------
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
-
R
-
K
Q
D
K
----------
D
N
T
M
N
V
--------------
I
H
M
----------------------
L
E
N
F
------
T
F
R
N
H
I
C
M
T
F
E
L
L
-
S
M
N
L
Y
E
L
I
K
K
-----------------------
N
-----------------------------------------------------
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
----
Q
C
L
D
A
L
H
--
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
K
Q
Q
G
-----------------------------------------------------------------------------------------------------------------------------------------
R
S
G
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
R
V
--------------
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
------
G
-
A
-
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
------
P
G
E
D
E
G
D
------
Q
L
A
C
-------------
M
I
E
L
L
G
M
-----------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
85.32
24%
0
- C- -
-
3BEG
-
A:
[124--1]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Q
G
L
P
L
P
C
V
K
K
I
I
Q
Q
V
L
----
Q
G
L
D
Y
L
H
TK
C
R
-
I
I
H
T
D
I
K
P
E
N
I
L
------
L
S
V
-
N
-----
E
Q
Y
I
R
R
--------
L
A
A
E
A
-----------------------------------------------------
A
G
N
F
L
V
N
P
L
E
-------------------------
P
K
N
A
E
K
L
--------------
K
V
K
I
A
D
L
G
N
A
C
W
V
-----------
H
K
H
F
T
---
E
D
I
Q
T
R
Q
Y
R
S
L
E
V
L
I
------
G
-
S
-
G
Y
N
T
P
A
D
I
W
S
T
A
C
M
A
F
E
L
A
T
G
D
Y
L
F
------
E
P
H
S
G
E
E
YT
R
D
E
D
H
I
A
L
-------------
I
I
E
L
L
G
K
V
-----
P
R
K
L
I
V
----
A
G
K
Y
S
K
E
F
F
T
K
K
G
D
L
K
H
I
T
K
------
L
K
P
--------
W
G
L
F
E
V
L
V
E
K
Y
E
W
S
Q
E
E
A
A
G
F
T
-----------------------------
D
F
L
L
P
M
L
E
L
I
----------
P
E
K
R
A
T
A
A
E
C
L
R
H
P
W
L
N
S
-
46
HHSearch
66.64
25%
-54
- C1 -
-
5BYZ
7
MK07_HUMAN
A:
[4-235]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
G
D
E
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
-----------
R
L
T
-
G
Q
Q
V
A
I
K
K
I
P
N
A
---------
F
DV
V
---
T
-------
N
A
K
R
T
L
R
E
L
K
I
L
K
H
F
-
K
-
H
D
----------------
N
I
--------------
I
A
I
K
---------------
D
I
L
R
-
P
T
V
P
Y
------
G
E
F
K
S
V
Y
V
V
L
D
L
M
-
E
S
D
L
H
Q
I
I
H
S
------------------------------------------------------------------------------
S
Q
P
L
T
L
E
H
V
R
Y
F
L
Y
Q
L
L
----
R
G
L
K
Y
M
H
--
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
E
N
-------------------------------------------------------------------------------------------------------------------------------------------
C
E
L
K
I
G
D
F
G
M
A
R
G
L
C
T
S
P
A
E
-------
H
Q
Y
F
M
T
E
Y
V
A
T
R
W
Y
R
A
P
E
L
M
L
------
S
L
H
-
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
R
R
Q
L
F
------
P
G
K
N
Y
V
H
------
Q
L
Q
L
-------------
I
M
M
V
L
G
T
P
-----
S
----------------------------------------------------------------------------------------------------------------------------------------
43
HHSearch
66.28
25%
-56
- C1 -
-
2Y7J
1
PHKG2_HUMAN
D:
[91-308]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
Y
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
-----------
R
A
T
-
G
H
E
F
A
V
K
I
M
E
V
-RLSPEQL--
E
------
E
-------
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
A
G
-
H
P
----------------
H
I
--------------
I
T
L
----------------------
I
D
S
Y
------
E
S
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
------------------------------------------------------------------------------
K
V
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
----
E
A
V
S
F
L
H
--
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
D
D
N
-------------------------------------------------------------------------------------------------------------------------------------------
M
Q
I
R
L
S
D
F
G
F
S
C
H
L
E
P
G
E
K
------------
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
CSMDET
H
-
P
-
G
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
------
W
H
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
65.30
25%
-43
- C1 -
-
1J1B
1
GSK3B_HUMAN
B:
[53-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
-----------
C
D
S
-
G
E
L
V
A
I
K
K
V
L
Q
D
---------
K
------
R
----------
F
K
N
R
E
L
Q
I
M
R
K
L
-
D
-
H
C
----------------
N
I
--------------
V
R
L
----------------------
R
Y
F
F
Y
S
S
GEK
K
D
E
V
Y
L
N
L
V
L
D
Y
V
-
P
E
T
V
Y
R
V
A
R
H
Y
S
R
--------------------------------------------------------------------------
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
----
R
S
L
A
Y
I
H
--
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
------------------------------------------------------------------------------------------------------------------------------------------
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
------------
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
------
G
-
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
------
P
G
D
S
G
V
D
------
Q
L
V
E
-------------
I
I
K
V
L
G
T
P
----------------------------------------------------------------------------------------------------------------------------------------------
51
HHSearch
64.49
24%
-48
- C1 -
-
2BDW
-
KCC2D_CAEEL
A:
[6-217]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
K
F
S
D
N
Y
D
V
K
E
E
L
G
K
G
A
F
S
V
V
R
R
C
V
H
-----------
K
T
T
-
G
L
E
F
A
A
K
I
I
N
T
K
---------
K
LS
A
---
R
-------
D
F
Q
K
L
E
R
E
A
R
I
C
R
K
L
-
Q
-
H
P
----------------
N
I
--------------
V
R
L
----------------------
H
D
S
I
------
Q
E
E
S
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
------------------------------------------------------------------------------
R
E
F
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
----
E
S
I
A
Y
C
H
--
S
N
G
I
V
H
R
N
L
K
P
E
N
L
L
L
A
S
K
A
K
----------------------------------------------------------------------------------------------------------------------------------------
G
A
A
V
K
L
A
D
F
G
L
A
I
E
V
N
D
S
E
A
------------
W
H
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
K
------
K
-
D
-
P
Y
S
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
D
E
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
HHSearch
64.29
23%
-74
- C1 -
-
3C0G
1
CSKP_HUMAN
B:
[21-235]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
-----------
R
E
T
-
G
Q
Q
F
A
V
K
I
V
D
V
A
---------
K
F
T
S
SPG
L
-------
S
T
E
D
L
K
R
E
A
S
I
C
H
M
L
-
K
-
H
P
----------------
H
I
--------------
V
E
L
----------------------
L
E
T
Y
------
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
--------------------------------------------------------------------------
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
----
E
A
L
R
Y
C
H
--
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
E
N
----------------------------------------------------------------------------------------------------------------------------------------
S
A
P
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
S
G
L
-----------
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
------
R
-
E
-
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
------
Y
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
HHSearch
64.06
23%
-79
- C1 -
-
3C0I
1
CSKP_HUMAN
A:
[20-235]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
-----------
R
E
T
-
G
Q
Q
F
A
V
K
I
V
D
V
A
---------
K
F
T
S
SPG
L
-------
S
T
E
D
L
K
R
E
A
S
I
C
H
M
L
-
K
-
H
P
----------------
H
I
--------------
V
E
L
----------------------
L
E
T
Y
------
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
--------------------------------------------------------------------------
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
----
E
A
L
R
Y
C
H
--
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
E
N
----------------------------------------------------------------------------------------------------------------------------------------
S
A
P
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
S
G
L
-----------
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
------
R
-
E
-
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
------
Y
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
63.82
25%
-36
- C1 -
-
2Y7J
1
PHKG2_HUMAN
C:
[91-308]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
Y
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
-----------
R
A
T
-
G
H
E
F
A
V
K
I
M
E
V
T
AERLSPEQL
E
------
E
-------
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
-
A
G
H
P
----------------
H
I
--------------
I
T
L
----------------------
I
D
S
Y
------
E
S
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
------------------------------------------------------------------------------
K
V
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
----
E
A
V
S
F
L
H
--
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
D
D
N
-------------------------------------------------------------------------------------------------------------------------------------------
M
Q
I
R
L
S
D
F
G
F
S
C
H
L
E
P
G
E
K
------------
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
CSMDET
H
-
P
-
G
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
------
W
H
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
HHSearch
63.75
25%
-54
- C1 -
-
2WEL
7
KCC2D_HUMAN
A:
[2-213]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
T
D
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
-----------
I
P
T
-
G
Q
E
Y
A
A
K
I
I
N
T
K
---------
K
LS
A
---
R
-------
D
H
Q
K
L
E
R
E
A
R
I
C
R
L
L
-
K
-
H
P
----------------
N
I
--------------
V
R
L
----------------------
H
D
S
I
------
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
------------------------------------------------------------------------------
R
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
----
E
S
V
N
H
C
H
--
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
K
----------------------------------------------------------------------------------------------------------------------------------------
G
A
A
V
K
L
A
D
F
G
L
A
I
E
V
Q
G
D
Q
Q
-----------
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
------
K
-
D
-
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
D
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
63.43
24%
-15
- C1 -
-
5MY8
22
?
A:
[126-383]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Q
G
L
P
L
P
C
V
K
K
I
I
Q
Q
V
L
----
Q
G
L
D
Y
L
H
TK
C
R
-
I
I
H
T
D
I
K
P
E
N
I
L
------
L
S
V
-
N
-----
E
Q
Y
I
R
R
--------
L
A
A
E
A
T
E
W
Q
R
---------------------------------------------------
F
L
V
N
P
L
E
-------------------------
P
K
N
A
E
K
L
--------------
K
V
K
I
A
D
L
G
N
A
C
W
V
-----------
H
K
H
F
T
---
E
D
I
Q
T
R
Q
Y
R
S
L
E
V
L
I
------
G
-
S
-
G
Y
N
T
P
A
D
I
W
S
T
A
C
M
A
F
E
L
A
T
G
D
Y
L
F
------
E
P
H
S
G
E
E
YT
R
D
E
D
H
I
A
L
-------------
I
I
E
L
L
G
K
V
-----
P
R
K
L
I
V
----
A
G
K
Y
S
K
E
F
F
T
K
K
G
D
L
K
H
I
T
K
------
L
K
P
--------
W
G
L
F
E
V
L
V
E
K
Y
E
W
S
Q
E
E
A
A
G
F
T
-----------------------------
D
F
L
L
P
M
L
E
L
I
----------
P
E
K
R
A
T
A
A
E
C
L
R
H
P
W
L
N
S
-
45
HHSearch
63.33
22%
-126
- C1 -
-
1UA2
1
CDK7_HUMAN
D:
[13-231]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
L
D
F
L
G
E
G
Q
F
A
T
V
Y
K
A
R
D
-----------
K
N
T
-
N
Q
I
V
A
I
K
K
I
----------------------------
N
R
T
A
L
R
E
I
K
L
L
Q
E
L
-
S
-
H
P
----------------
N
I
--------------
I
G
L
----------------------
L
D
A
F
------
G
H
K
S
N
I
S
L
V
F
D
F
M
-
E
T
D
L
E
V
I
I
K
D
-----------------------------------------------------------------------------
N
S
L
V
L
T
P
S
H
I
K
A
Y
M
L
M
T
L
----
Q
G
L
E
Y
L
H
--
Q
H
W
I
L
H
R
D
L
K
P
N
N
L
L
L
D
E
N
-------------------------------------------------------------------------------------------------------------------------------------------
G
V
L
K
L
A
D
F
G
L
A
K
S
F
G
S
P
N
-----------
R
A
Y
T
H
Q
V
V
T
R
W
Y
R
A
P
E
L
L
F
------
G
-
A
R
M
Y
G
V
G
V
D
M
W
A
V
G
C
I
L
A
E
L
L
L
R
V
P
F
L
------
P
G
D
S
D
L
D
------
Q
L
T
R
-------------
I
F
E
T
L
G
T
-----------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
61.83
24%
-15
- C1 -
-
1WAK
4
SRPK1_HUMAN
A:
[140-397]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Q
G
L
P
L
P
C
V
K
K
I
I
Q
Q
V
L
----
Q
G
L
D
Y
L
H
TK
C
R
-
I
I
H
T
D
I
K
P
E
N
I
L
------
L
S
V
-
N
-----
E
Q
Y
I
R
R
--------
L
A
A
E
A
----------------------------------------------------
T
A
G
N
F
L
V
N
P
L
E
-------------------------
P
K
N
A
E
K
L
--------------
K
V
K
I
A
D
L
G
N
A
C
W
V
-----------
H
K
H
F
T
---
E
D
I
Q
T
R
Q
Y
R
S
L
E
V
L
I
------
G
-
S
-
G
Y
N
T
P
A
D
I
W
S
T
A
C
M
A
F
E
L
A
T
G
D
Y
L
F
------
E
P
H
S
G
E
E
YT
R
D
E
D
H
I
A
L
-------------
I
I
E
L
L
G
K
V
-----
P
R
K
L
I
V
----
A
G
K
Y
S
K
E
F
F
T
K
K
G
D
L
K
H
I
T
K
------
L
K
P
--------
W
G
L
F
E
V
L
V
E
K
Y
E
W
S
Q
E
E
A
A
G
F
T
-----------------------------
D
F
L
L
P
M
L
E
L
I
----------
P
E
K
R
A
T
A
A
E
C
L
R
H
P
W
L
N
S
-
31
HHSearch
60.54
22%
-103
- C1 -
-
1TKI
-
TITIN_HUMAN
A:
[20-226]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Y
E
K
Y
M
I
A
E
D
L
G
R
G
E
F
G
I
V
H
R
C
V
E
-----------
T
S
S
-
K
K
T
Y
M
A
K
F
V
K
V
K
---------
G
------
T
-------
D
Q
V
L
V
K
K
E
I
S
I
L
N
I
A
-
R
-
H
R
----------------
N
I
--------------
L
H
L
----------------------
H
E
S
F
------
E
S
M
E
E
L
V
M
I
F
E
F
I
S
G
L
D
I
F
E
R
I
N
T
-----------------------------------------------------------------------------
S
A
F
E
L
N
E
R
E
I
V
S
Y
V
H
Q
V
C
----
E
A
L
Q
F
L
H
--
S
H
N
I
G
H
F
D
I
R
P
E
N
I
I
Y
Q
T
R
R
-----------------------------------------------------------------------------------------------------------------------------------------
S
S
T
I
K
I
I
E
F
G
Q
A
R
Q
L
K
P
G
D
N
------------
F
R
L
L
F
T
A
P
E
Y
Y
A
P
E
V
H
Q
------
H
-
D
-
V
V
S
T
A
T
D
M
W
S
L
G
T
L
V
Y
V
L
L
S
G
I
N
P
F
------
L
A
E
T
N
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
60.43
24%
-14
- C1 -
-
4WUA
2
?
A:
[144-401]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Q
G
L
P
L
P
C
V
K
K
I
I
Q
Q
V
L
----
Q
G
L
D
Y
L
H
TK
C
R
-
I
I
H
T
D
I
K
P
E
N
I
L
------
L
S
V
-
N
-----
E
Q
Y
I
R
R
--------
L
A
A
E
A
T
---------------------------------------------------------
V
N
P
L
E
-------------------------
P
K
N
A
E
K
L
--------------
K
V
K
I
A
D
L
G
N
A
C
W
V
-----------
H
K
H
F
T
---
E
D
I
Q
T
R
Q
Y
R
S
L
E
V
L
I
------
G
-
S
-
G
Y
N
T
P
A
D
I
W
S
T
A
C
M
A
F
E
L
A
T
G
D
Y
L
F
------
E
P
H
S
G
E
E
YT
R
D
E
D
H
I
A
L
-------------
I
I
E
L
L
G
K
V
-----
P
R
K
L
I
V
----
A
G
K
Y
S
K
E
F
F
T
K
K
G
D
L
K
H
I
T
K
------
L
K
P
--------
W
G
L
F
E
V
L
V
E
K
Y
E
W
S
Q
E
E
A
A
G
F
T
-----------------------------
D
F
L
L
P
M
L
E
L
I
----------
P
E
K
R
A
T
A
A
E
C
L
R
H
P
W
L
N
S
-
29
Fugue
59.34
14%
-6
- C1 -
-
3C4Z
1
RK_BOVIN
A:
[31-533]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
C
E
------
A
L
R
E
S
L
D
L
G
F
E
G
M
-
C
L
E
Q
P
I
G
K
R
L
F
Q
Q
F
L
R
T
H
E
Q
H
G
P
A
L
Q
L
W
K
D
I
E
D
Y
D
-------
T
A
D
D
A
L
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
E
P
Q
A
Q
L
F
C
S
F
L
D
A
E
T
V
A
R
A
R
A
G
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
--
W
K
W
L
E
A
Q
P
M
G
E
D
W
--
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
K
A
T
G
K
L
Y
A
C
K
K
L
N
K
K
R
L
K
K
R
K
G
Y
Q
G
A
M
V
E
K
K
I
L
A
K
V
H
S
R
FI
V
S
L
A
Y
A
F
E
T
K
T
-
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
V
D
E
D
N
P
G
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
R
N
I
I
Y
R
D
L
K
P
E
N
---
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
A
V
E
L
K
A
-----------
G
Q
T
K
T
K
G
Y
A
G
T
P
G
F
M
A
P
E
L
L
L
------
G
-
E
-
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
RARG
E
K
V
E
N
K
E
L
K
------
Q
R
V
L
E
Q
A
V
T
Y
P
DKFS
P
A
S
K
D
F
C
E
A
L
L
QKDP
E
K
R
L
G
F
R
D
G
S
C
D
G
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
GMLTPP
F
V
P
D
S
R
T
V
Y
A
K
N
G
A
F
S
G
V
A
F
E
K
A
D
T
E
F
F
Q
E
F
A
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
--
G
V
F
G
D
L
N
V
W
R
P
-----------------------------------------
52
HHSearch
58.08
21%
-66
- C1 -
-
4XBR
1
INKA1_HUMAN
A:
[93-293]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
-----------
R
S
S
-
G
K
L
V
A
V
K
K
M
D
L
R
---------
K
Q-----
Q
-------
R
R
E
L
L
F
N
E
V
V
I
M
R
D
Y
-
Q
-
H
E
----------------
N
V
--------------
V
E
M
----------------------
Y
N
S
Y
------
L
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
-------------------------------------------------------------------------------
T
R
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
----
Q
A
L
S
V
L
H
--
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
-------------------------------------------------------------------------------------------------------------------------------------------
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
P
-----------
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
------
R
-
L
-
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
------
F
N
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
56.21
22%
-37
- C1 -
-
4B4L
3
DAPK1_HUMAN
A:
[7-222]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Q
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
-----------
K
S
T
-
G
L
Q
Y
A
A
K
F
I
K
K
R
---------
R
------
T
KSSRRGV
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
-
Q
-
H
P
----------------
N
V
--------------
I
T
L
----------------------
H
E
V
Y
------
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
------------------------------------------------------------------------------
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
----
N
G
V
Y
Y
L
H
--
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
---------------------------------------------------------------------------------------------------------------------------------------
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
N
E
------------
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
-
E
-
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
56.08
22%
-33
- C1 -
-
2X0G
-
DAPK1_HUMAN
A:
[7-220]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
-----------
K
S
T
-
G
L
Q
Y
A
A
K
F
I
K
K
R
---------
R
------
T
KSSRRGV
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
-
Q
-
H
P
----------------
N
V
--------------
I
T
L
----------------------
H
E
V
Y
------
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
------------------------------------------------------------------------------
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
----
N
G
V
Y
Y
L
H
--
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
---------------------------------------------------------------------------------------------------------------------------------------
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
N
E
------------
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
-
E
-
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------