@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_25_2070: (2018-03-10 )
MEAVVKLNRKLGVGGRGVVYEGFDHARGHFVAIKELAYMEPSVADEDDTELAAILSELAYMREAQHTNLVEYYGARRCAIGIQIIMEYVSGGSLDYVLTRCGPLRENVARAYTRDVLEALHYLHKTMHVCHRDVKPANILITPDGRCKLADFGVAKQVDATTPTRPAHAERGGKGMGKEEEGNSPRHRNGGRQGYLQTAVGTPWYMAPEVINGGVEDDDDGDEDLELGNACAVTIDGDANSGSFSGSFSEDWTSSGLAHTVPDASASPPPLYSSSSYYNPLKSIVKKGRLGARSVGYTTSADIWSVGVTVYEMVTGTKPFGADLTNPSAVLFRIANCAASPPQLPADVHVSAELHSFLDLCFVYDKDLRATAAELLGHPWLGPVRKGGGSGGDNASADEKPRRQLFNGKRHSRSGMRVDEGEQVQRHQQLAAQRTVFDGVPLLDSIDLPAYPATTAVSSPASSAVAECGGSGEGAHPAPDTSPRRARHSVHRLSCSGTHCSGCSVTRRSPSTISPPLSSVSIAEQAEASSRYAAVRQRIGHTRATNSAHTAASAAPLAAQSNPGSLFSTRGEFVDFMSHP
Atome Classification :
(21 SA)
----------------------------------------------------------------.........10........20........30........40....-....50........60..-.-.....70.......----.80........90.-.......100.----.......110.......120......--.130.......140---.--.--.---.----....150.......160.......170.......180..-.---....190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320....-...-330.......340.......350.......360......---.370.......380.......390.......400.......410........420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
----------------------------------------------------------------M
E
A
V
V
K
L
N
R
KLGVGGRG
V
V
YEGFDHARG
H
F
V
A
I
K
E
L
A
YMEPSVAD-ED
D
T
E
L
A
A
I
L
S
E
L
A
Y
M
R
E-A-QHT
N
L
V
E
Y
YGA
R
R
C
----
A
I
G
I
Q
I
I
M
E
Y
VSGG-S
L
D
Y
V
L
TRC-G----
P
L
R
E
N
V
A
R
A
Y
T
R
D
V
L
E
A
L
H
Y
L
H
K
T
M
H
--
V
C
HRDVKP
A
N
I
L
I----T--P--D---G----
R
C
K
LADFGVAKQVDATTPTR
P
A
H
AERGGKGMGKEEEGNS-P---RHRNGGRQ
G
Y
L
Q
TAVGTPWYM
A
P
E
V
INGGVEDDDDGDEDLELG
N
A
C
A
V
T
IDGDANSGSFSGSFSEDWTSSGLAHTVPDASASPPPLYSSSS
Y
Y
N
P
L
K
S
I
V
K
KGRLGARSVGYTTSA
D
I
W
S
V
G
V
T
V
Y
E
M
VTGTKPFGADLT
N
-
P
S
A
-
V
L
F
R
I
A
N
CAASPPQLPA
D
V
H
V
S
A
E
L
H
S
F
L
D
L
C
F
VYDK
D
L
---
R
A
T
A
A
E
LLGHPWLG
P
V
RKGGGSGGDNASA
D
E
K
P
R
R
Q
L
FNGKRH-SRSGMRVD
E
G
E
Q
V
Q
R
H
Q
Q
L
A
A
Q
R
TVFDGVPLLDSIDLPAYPATTAVSS
P
A
S
S
A
V
A
ECGGSGEGAHPAPDTS
P
R
R
A
R
HS
V
H
R
LSCSGTHCSGCSVTRRSPSTISPPL
S
S
V
S
I
A
E
Q
AEA
S
S
R
Y
A
A
V
R
Q
RIGHTRATNSAHTAASAAPLAAQSNPGSLFSTR
G
E
F
V
D
FMSHP
39
HHSearch
78.53
38%
-114
- C1 -
-
4XBR
1
INKA1_HUMAN (first)
A:
[95-350]
-------------------------------------------------------------------
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
--------
Q
Q
R
R
E
L
L
F
N
E
V
V
I
M
R
D
-
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
----
G
D
E
L
W
V
V
M
E
F
L
E
G
G
-
A
L
T
D
I
V
T
H
T
------
R
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
-
G
--
V
I
H
R
D
I
K
S
D
S
I
L
L
----
T
--
H
--
D
---
G
----
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
P
-----------------------------------
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
R
L
---------------------------------------------------------------------------------
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
---
P
L
K
-
A
M
K
M
I
R
D
--
N
L
P
P
R
L
K
N
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
---
R
A
T
A
A
E
L
L
K
H
P
F
L
A
K
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
HHSearch
76.14
30%
-110
- C1 -
-
4WOT
1
ROCK2_HUMAN
B:
[71-339]
--------------------------------------------------------------------
Y
D
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
A
S
Q
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
-----
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
-
A
-
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
----
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
-
D
L
V
N
L
M
S
N
--
Y
----
D
V
P
E
K
W
A
K
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
M
-
G
--
L
I
H
R
D
V
K
P
D
N
M
L
L
----
D
--
K
--
H
---
G
----
H
L
K
L
A
D
F
G
T
C
M
K
M
D
E
T
G
M
----------------------------------
V
H
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
G
G
-----------------------------------------------------------------------------
D
G
F
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
--
S
-
L
V
G
-
T
Y
S
K
I
M
D
H
K
N
-
S
L
C
F
P
E
D
A
E
I
S
K
H
A
K
N
L
I
C
A
F
L
T
D
R
E
V
R
LG-
R
N
G
V
E
E
I
R
Q
H
P
F
F
K
N
D
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
72.21
34%
-112
- C1 -
-
5J5T
1
M4K3_HUMAN
A:
[5-268]
-------------------------------------------------------------------
D
F
E
L
I
Q
R
I
G
S
G
T
Y
G
D
V
Y
K
A
R
N
V
N
T
G
E
L
A
A
I
K
V
I
K
L
E
P
--------
G
E
D
F
A
V
V
Q
Q
E
I
I
M
M
K
D
-
C
-
K
H
P
N
I
V
A
Y
F
G
S
Y
L
R
----
R
D
K
L
W
I
C
M
E
F
C
G
G
G
-
S
L
Q
D
I
Y
H
V
T
-
G
----
P
L
S
E
L
Q
I
A
Y
V
S
R
E
T
L
Q
G
L
Y
Y
L
H
S
K
-
G
--
K
M
H
R
D
I
K
G
A
N
I
L
L
----
T
--
D
--
N
---
G
----
H
V
K
L
A
D
F
G
V
S
A
Q
I
T
A
T
I
A
--------------------------------------
A
F
I
G
T
P
Y
W
M
A
P
E
V
A
A
V
E
R
------------------------------------------------------------------------------
K
G
G
Y
N
Q
L
C
D
L
W
A
V
G
I
T
A
I
E
L
A
E
L
Q
P
P
M
F
D
L
H
---
P
M
R
-
A
L
F
L
M
T
K
S
N
F
Q
P
P
K
L
K
D
K
M
K
W
S
N
S
F
H
H
F
V
K
M
A
L
T
K
N
P
K
K
---
R
P
T
A
E
K
L
L
Q
H
P
F
V
T
Q
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
63.90
27%
-54
- C1 -
-
4B4L
3
DAPK1_HUMAN
A:
[12-281]
-----------------------------------------------------------------
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
--
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
-
I
-
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
----
K
T
D
V
I
L
I
L
E
L
V
A
G
G
-
E
L
F
D
F
L
A
E
K
-
E
----
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
-
Q
--
I
A
H
F
D
L
K
P
E
N
I
M
L
----
L
--
D
--
R
---
N
VP
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
N
------------------------------------
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
---------------------------------------------------------------------------------
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
---
Q
E
-
T
L
A
N
V
S
A
V
N
Y
-
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
---
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
HHSearch
62.85
23%
-107
- C1 -
-
2E9N
1
CHK1_HUMAN
A:
[6-266]
------------------------------------------------------------------
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
A
-------
V
D
C
P
E
N
I
K
K
E
I
C
I
N
K
M
-
L
-
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
----
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
-
E
L
F
D
R
I
E
P
D
-
I
----
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
-
G
--
I
T
H
R
D
I
K
P
E
N
L
L
L
----
D
--
E
--
R
---
D
----
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
---------------------------------
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
--------------------------------------------------------------------------------
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
--
S
C
Q
-
E
Y
S
D
W
K
E
K
---
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
---
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
60.92
25%
-12
* C1 *
-
2Y7J
1
PHKG2_HUMAN
C:
[96-364]
--------------------------------------------------------------------
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
V
T
A
E
R
L
S
P
E
Q
L
E
E
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
-
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
----
S
S
F
M
F
L
V
F
D
L
M
R
K
G
-
E
L
F
D
Y
L
T
E
K
-
V
----
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
-
N
--
I
V
H
R
D
L
K
P
E
N
I
L
L
----
D
--
D
--
N
---
M
----
Q
I
R
L
S
D
F
G
F
S
C
H
L
E
P
G
E
K
------------------------------------
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
C
S
M
D
E
---------------------------------------------------------------------------
T
H
P
G
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
R
R
---
Q
I
L
-
M
L
R
M
I
M
E
G
Q
-
Y
Q
F
S
S
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
---
R
L
T
A
E
Q
A
L
Q
H
P
F
F
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
60.83
25%
-11
- C1 -
-
2Y7J
1
PHKG2_HUMAN
D:
[96-364]
--------------------------------------------------------------------
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
V
---
R
L
S
P
E
Q
L
E
E
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
-
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
----
S
S
F
M
F
L
V
F
D
L
M
R
K
G
-
E
L
F
D
Y
L
T
E
K
-
V
----
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
-
N
--
I
V
H
R
D
L
K
P
E
N
I
L
L
----
D
--
D
--
N
---
M
----
Q
I
R
L
S
D
F
G
F
S
C
H
L
E
P
G
E
K
------------------------------------
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
C
S
M
D
E
---------------------------------------------------------------------------
T
H
P
G
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
R
R
---
Q
I
L
-
M
L
R
M
I
M
E
G
Q
-
Y
Q
F
S
S
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
---
R
L
T
A
E
Q
A
L
Q
H
P
F
F
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
60.08
27%
-52
- C1 -
-
2X0G
-
DAPK1_HUMAN
A:
[11-278]
------------------------------------------------------------------
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
-
S
-
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
-
I
-
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
----
K
T
D
V
I
L
I
L
E
L
V
A
G
G
-
E
L
F
D
F
L
A
E
K
-
E
----
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
-
Q
--
I
A
H
F
D
L
K
P
E
N
I
M
L
----
L
--
D
--
R
---
N
VP
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
N
E
------------------------------------
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
---------------------------------------------------------------------------------
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
---
Q
E
-
T
L
A
N
V
S
A
V
N
Y
-
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
---
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
59.63
28%
-70
- C1 -
-
4LQS
1
CBK1_YEAST
A:
[104-453]
--------------------------------------------------------------------
F
H
T
V
K
V
I
G
K
G
A
F
G
E
V
R
L
V
Q
K
K
D
T
G
K
I
Y
A
M
K
T
L
L
K
S
E
M
-----
Y
K
K
----------------
S
-
D
S
P
W
V
V
S
L
Y
Y
S
F
Q
D
----
A
Q
Y
L
Y
L
I
M
E
F
L
P
G
G
-
D
L
M
T
M
L
I
R
W
-
Q
----
L
F
T
E
D
V
T
R
F
Y
M
A
E
C
I
L
A
I
E
T
I
H
K
L
-
G
--
F
I
H
R
A
I
K
P
D
N
I
L
I
----
D
--
I
--
R
---
G
----
H
I
K
L
S
D
F
G
L
S
T
G
F
H
K
T
H
D
S
N
Y
------------------N
R
QQ
I
Q
T
W
R
K
S
R
R
L
M
A
Y
S
T
V
G
T
P
D
Y
I
A
P
E
I
F
L
Y
Q
---------------------------------------------------------------------------------
G
Y
G
Q
E
C
D
W
W
S
L
G
A
I
M
Y
E
C
L
I
G
W
P
P
F
C
S
E
--
T
-
P
Q
E
-
T
Y
R
K
I
M
N
F
E
-
Q
T
L
Q
F
P
D
D
I
H
I
S
Y
E
A
E
D
L
I
R
R
L
L
T
H
A
D
Q
R
LGR
H
G
G
A
D
E
I
K
S
H
P
F
F
R
G
V
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
Fugue
59.14
22%
10
- C1 -
-
1TKI
-
TITIN_HUMAN
A:
[18-338]
--------------------------------------------------------------KE
L
Y
E
K
Y
M
I
A
E
D
L
G
R
G
E
F
G
I
V
H
R
C
V
E
T
S
S
K
K
T
Y
M
A
K
F
V
--------
K
-
V
K
G
T
D
Q
V
L
V
K
K
E
I
S
I
L
N
I
-
A
-
R
H
R
N
I
L
H
L
H
E
S
F
E
S
----
M
E
E
L
V
M
I
F
E
F
I
S
G
L
D
I
F
E
R
I
N
T
S
A
-
F
----
E
L
N
E
R
E
I
V
S
Y
V
H
Q
V
C
E
A
L
Q
F
L
H
S
-
H
N
--
I
G
H
F
D
I
R
P
E
N
I
I
Y
----
Q
TR
R
--
S
---
S
----
T
I
K
I
I
E
F
G
Q
A
R
Q
L
K
------------------------------------
P
G
D
N
F
R
L
L
F
T
A
P
E
Y
Y
A
P
E
V
H
Q
H
D
---------------------------------------------------------------------------------
V
V
S
T
A
T
D
M
W
S
L
G
T
L
V
Y
V
L
L
S
G
I
N
P
F
L
A
E
--
T
-
N
Q
Q
-
I
I
E
N
I
M
N
A
E
Y
T
F
D
E
E
A
F
K
-
E
I
S
I
E
A
M
D
F
V
D
R
L
L
V
K
E
R
K
S
---
R
M
T
A
S
E
A
L
Q
H
P
W
L
K
Q
K
I
E
R
V
S
T
K
V
I
R
T
L
K
H
R
R
Y
Y
H
T
L
I
K
K
D
L
N
M
V
V
S
A
A
R
I
S
C
G
G
A
I
R
S
Q
K
G
V
S
V
A
K
V
K
V
A
S
I
--------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
59.09
27%
-56
- C1 -
-
3C0I
1
CSKP_HUMAN
A:
[24-294]
------------------------------------------------------------------
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
--
S
-
S
P
G
L
S
T
E
D
L
K
R
E
A
S
I
C
H
M
-
L
-
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
----
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
-
D
L
C
F
E
I
V
K
R
-
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
-
N
--
I
I
H
R
D
V
K
P
H
C
V
L
L
----
A
--
S
--
K
ENS
A
----
P
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
S
G
L
-----------------------------------
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
R
E
---------------------------------------------------------------------------------
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
K
----
E
R
-
L
F
E
G
I
I
K
G
K
Y
K
-
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
---
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
Fugue
58.80
27%
-7
- C1 -
-
4DN5
7
M3K14_HUMAN
A:
[8-351]
S
V
E
E
Y
L
V
H
A
L
QG
S
V
S
S
G
Q
A
H
S
L
T
S
L
A
K
T
W
A
A
R
G
S
RSREPSPKTE
D
N
E
G
V
L
LTEK
L
K
P
V
DY
E
Y
R
E
E
V
H
W
A
T
H
Q
L
R
L
G
R
G
S
F
G
E
V
H
R
M
E
D
K
Q
T
G
F
Q
C
A
V
K
K
V
R
L
E
V
F
R
A
-------------
E
E
L
M
A
C
A
G
-
L
-
T
S
P
R
I
V
P
L
Y
G
A
V
R
E
----
G
P
W
V
N
I
F
M
E
L
L
E
G
G
-
S
L
G
Q
L
V
K
E
Q
-
G
----
C
L
P
E
D
R
A
L
Y
Y
L
G
Q
A
L
E
G
L
E
Y
L
H
S
-
R
R
--
I
L
H
G
D
V
K
A
D
N
V
L
L
----
S
--
S
--
D
---
G
S---
H
A
A
L
C
D
F
G
H
A
V
C
L
Q
I
P
-------------------------------------------
G
T
E
T
H
M
A
P
E
V
V
L
G
R
---------------------------------------------------------------------------------
S
C
D
A
K
V
D
V
W
S
S
C
C
M
M
L
H
M
L
N
G
C
H
P
W
T
Q
--
F
F
-
R
G
P
-
L
C
L
K
I
A
S
--
E
P
P
P
V
R
E
I
P
P
S
C
A
P
L
T
A
Q
A
I
Q
E
G
L
R
K
E
P
I
H
---
R
V
S
A
A
E
L
G
G
K
V
N
R
A
L
Q
Q
V
G
G
L
K
S
P
W
R
G
E
Y
K
E
P
R
H
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
HHSearch
58.33
26%
-66
- C1 -
-
2BDW
-
KCC2D_CAEEL
A:
[12-275]
-------------------------------------------------------------------
N
Y
D
V
K
E
E
L
G
K
G
A
F
S
V
V
R
R
C
V
H
K
T
T
G
L
E
F
A
A
K
I
I
N
T
K
K
L
------
S
A
R
D
F
Q
K
L
E
R
E
A
R
I
C
R
K
-
L
-
Q
H
P
N
I
V
R
L
H
D
S
I
Q
E
----
E
S
F
H
Y
L
V
F
D
L
V
T
G
G
-
E
L
F
E
D
I
V
A
R
-
E
----
F
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
I
A
Y
C
H
S
N
-
G
--
I
V
H
R
N
L
K
P
E
N
L
L
L
----
A
--
S
--
K
---
A
KG
A
-
A
V
K
L
A
D
F
G
L
A
I
E
V
N
D
S
E
------------------------------------
A
W
H
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
K
K
D
---------------------------------------------------------------------------------
P
Y
S
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
--
D
-
Q
H
R
-
L
Y
A
Q
I
K
A
G
A
Y
-
D
Y
P
S
P
E
W
D
T
V
T
P
E
A
K
S
L
I
D
S
M
L
T
V
N
P
K
K
---
R
I
T
A
D
Q
A
L
K
V
P
W
I
C
N
R
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
Fugue
57.85
19%
21
- C1 -
-
1KOB
1
?
A:
[23-374]
--------------------------------------INDYDKFYEDIWKK
Y
V
P
Q
P
V
E
V
K
QGS
V
Y
D
Y
Y
D
I
L
E
E
L
G
S
G
A
F
G
V
V
H
R
C
V
E
K
A
T
G
R
V
F
V
A
K
F
I
N
T
--------
P
Y
P
L
D
K
Y
T
V
K
N
E
I
S
I
M
N
Q
-
L
-
H
H
P
K
L
I
N
L
H
D
A
F
E
D
----
K
Y
E
M
V
L
I
L
E
F
L
S
G
G
E
L
F
D
R
I
A
A
E
D
-
Y
----
K
M
S
E
A
E
V
I
N
Y
M
R
Q
A
C
E
G
L
K
H
M
H
E
H
-
S
--
I
V
H
L
D
I
K
P
E
N
I
M
C
----
E
TK
K
--
A
---
S
----
S
V
K
I
I
D
F
G
L
A
T
K
L
N
P
D
E
I
------------------------------------
V
K
V
T
T
A
T
A
E
F
A
A
P
E
I
V
D
R
E
---------------------------------------------------------------------------------
P
V
G
F
Y
T
D
M
W
A
I
G
V
L
G
Y
V
L
L
S
G
L
S
P
F
A
G
E
--
D
-
D
L
E
-
T
L
Q
N
V
K
R
C
D
W
E
F
D
E
D
A
F
S
-
S
V
S
P
E
A
K
D
F
I
K
N
L
L
Q
K
E
P
R
K
---
R
L
T
V
H
D
A
L
E
H
P
W
L
K
G
D
H
S
N
L
T
S
R
I
P
S
S
R
Y
N
K
I
R
Q
K
I
K
E
K
Y
A
D
W
-
P
A
P
Q
P
A
I
G
R
I
A
N
F
S
S
L
R
K
H
R
P
Q
E
Y
Q
I
Y
D
S
Y
F
D
R
K
E
A
-------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
56.74
31%
-74
- C1 -
-
5IU2
1
M3K8_HUMAN
B:
[78-326]
-----------------------------------------------------------------------
S
D
F
I
P
R
G
A
F
G
K
V
Y
L
A
Q
D
I
K
T
K
K
R
M
A
C
K
L
I
P
V
D
Q
-------------
F
K
P
S
D
V
E
I
Q
A
C
-
F
-
R
H
E
N
I
A
E
L
Y
G
A
V
L
W
----
G
E
T
V
H
L
F
M
E
A
G
E
G
G
-
S
V
L
E
K
L
E
S
C
-
G
----
P
M
R
E
F
E
I
I
W
V
T
K
H
V
L
K
G
L
D
F
L
H
S
K
-
K
--
V
I
H
H
D
I
K
P
S
N
I
V
F
----
M
--
S
--
T
--------
K
A
V
L
V
D
F
G
L
S
V
Q
M
T
E
D
V
Y
-----------------------------------
F
P
K
D
L
R
G
T
E
I
Y
M
S
P
E
V
I
L
C
R
---------------------------------------------------------------------------------
G
H
S
T
K
A
D
I
Y
S
L
G
A
T
L
I
H
M
Q
T
G
T
P
P
W
V
K
R
Y
P
R
-
S
A
Y
P
S
Y
L
Y
I
I
H
K
Q
-
A
P
P
L
E
D
I
A
D
D
C
S
P
G
M
R
E
L
I
E
A
S
L
E
R
N
P
N
H
---
R
P
R
A
A
D
L
L
K
H
E
A
L
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
56.57
30%
-41
- C1 -
-
2X4F
4
MYLK4_HUMAN
A:
[91-350]
--------------------------------------------------------------------
V
S
K
T
E
I
L
G
-----
Q
V
H
K
C
E
E
T
A
T
G
L
K
L
A
A
K
I
I
K
T
R
G
M
--------
K
D
K
E
E
V
K
N
E
I
S
V
M
N
Q
-
L
-
D
H
A
N
L
I
Q
L
Y
D
A
F
E
S
----
K
N
D
I
V
L
V
M
E
Y
V
D
G
G
-
E
L
F
D
R
I
I
D
E
S
Y
----
N
L
T
E
L
D
T
I
L
F
M
K
Q
I
C
E
G
I
R
H
M
H
Q
M
-
Y
--
I
L
H
L
D
L
K
P
E
N
I
L
C
VN--
R
--
D
--
A
---
K
----
Q
I
K
I
I
D
F
G
L
A
R
R
Y
K
P
R
E
------------------------------------
K
L
K
V
N
F
G
T
P
E
F
L
A
P
E
V
V
N
Y
D
---------------------------------------------------------------------------------
F
V
S
F
P
T
D
M
W
S
V
G
V
I
A
Y
M
L
L
S
G
L
S
P
F
L
G
D
N
---
D
A
E
-
T
L
N
N
I
L
A
C
R
W
D
-
L
E
D
E
E
F
Q
D
I
S
E
E
A
K
E
F
I
S
K
L
L
I
K
E
K
S
W
---
R
I
S
A
S
E
A
L
K
H
P
W
L
S
D
H
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
54.64
27%
-56
- C1 -
-
3C0G
1
CSKP_HUMAN
B:
[24-294]
------------------------------------------------------------------
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
--
S
-
S
P
G
L
S
T
E
D
L
K
R
E
A
S
I
C
H
M
-
L
-
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
----
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
-
D
L
C
F
E
I
V
K
R
-
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
-
N
--
I
I
H
R
D
V
K
P
H
C
V
L
L
----
A
--
S
--
K
ENS
A
----
P
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
S
G
L
-----------------------------------
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
R
E
---------------------------------------------------------------------------------
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
K
----
E
R
-
L
F
E
G
I
I
K
G
K
Y
-
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
---
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
53.55
26%
-44
- C1 -
-
1TKI
-
TITIN_HUMAN
A:
[22-282]
------------------------------------------------------------------
E
K
Y
M
I
A
E
D
L
G
R
G
E
F
G
I
V
H
R
C
V
E
T
S
S
K
K
T
Y
M
A
K
F
V
K
V
K
G
---------
T
D
Q
V
L
V
K
K
E
I
S
I
L
N
I
-
A
-
R
H
R
N
I
L
H
L
H
E
S
F
E
S
----
M
E
E
L
V
M
I
F
E
F
I
S
G
L
-
D
I
F
E
R
I
N
T
S
A
F
----
E
L
N
E
R
E
I
V
S
Y
V
H
Q
V
C
E
A
L
Q
F
L
H
S
H
-
N
--
I
G
H
F
D
I
R
P
E
N
I
I
Y
----
Q
--
T
RR
S
---
S
----
T
I
K
I
I
E
F
G
Q
A
R
Q
L
K
P
G
D
------------------------------------
N
F
R
L
L
F
T
A
P
E
Y
Y
A
P
E
V
H
Q
H
D
---------------------------------------------------------------------------------
V
V
S
T
A
T
D
M
W
S
L
G
T
L
V
Y
V
L
L
S
G
I
N
P
F
L
A
E
--
T
-
N
Q
Q
-
I
I
E
N
I
M
N
A
E
Y
T
-
F
D
E
E
A
F
K
E
I
S
I
E
A
M
D
F
V
D
R
L
L
V
K
E
R
K
S
---
R
M
T
A
S
E
A
L
Q
H
P
W
L
K
Q
K
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
51.69
27%
-25
- C1 -
-
5O2C
4
WNK3_HUMAN
A:
[25-289]
------------------------------------------------------------------
R
F
L
K
F
D
I
E
L
G
R
G
A
F
K
T
V
Y
K
G
L
D
T
E
T
W
V
E
V
A
W
C
E
L
Q
D
R
K
L
------
T
K
A
E
Q
Q
R
F
K
E
E
A
E
M
L
K
G
-
L
-
Q
H
P
N
I
V
R
F
Y
D
S
W
E
S
I
L
KG
K
K
C
I
V
L
V
T
E
L
M
T
S
G
-
T
L
K
T
Y
L
K
R
F
-
K
----
V
M
K
P
K
V
L
R
S
W
C
R
Q
I
L
K
G
L
Q
F
L
H
T
R
-
T
PP
I
I
H
R
D
L
K
C
D
N
I
F
I
----
T
G-
P
--
T
---
G
----
S
V
K
I
G
D
L
G
L
A
T
L
M
R
T
S
-------------------------------------
F
A
K
S
V
I
G
T
P
E
F
M
A
P
E
M
Y
E
E
----------------------------------------------------------------------------------
H
Y
D
E
S
V
D
V
Y
A
F
G
M
C
M
L
E
M
A
T
S
E
Y
P
Y
S
E
C
Q
-
N
-
A
A
Q
-
I
Y
R
K
V
T
S
G
-
I
K
P
A
S
F
--
N
K
V
T
D
P
E
V
K
E
I
I
E
G
C
I
R
Q
N
K
S
E
---
R
L
S
I
R
D
L
L
N
H
A
F
F
A
E
D
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
50.81
29%
-42
- C1 -
-
2QR8
-
A:
[23-284]
-------------------------------------------------------------------
G
Y
E
V
K
E
D
I
G
V
G
S
Y
S
V
C
K
R
C
I
H
K
A
T
N
M
E
F
A
V
K
I
I
D
K
S
K
------------
R
D
P
T
E
E
I
E
I
L
L
R
Y
G
-
Q
H
P
N
I
I
T
L
K
D
V
Y
D
D
----
G
K
Y
V
Y
V
V
T
E
L
M
K
G
G
-
E
L
L
D
K
I
L
R
Q
-
K
----
F
F
S
E
R
E
A
S
A
V
L
F
T
I
T
K
T
V
E
Y
L
H
A
Q
-
G
--
V
V
H
R
D
L
K
P
S
N
I
L
Y
VDES
G
--
N
--
P
---
E
----
S
I
R
I
C
D
F
G
F
A
K
Q
L
R
A
E
N
G
-----------------------------------
L
L
M
T
P
C
Y
T
A
N
F
V
A
P
E
V
L
E
R
Q
---------------------------------------------------------------------------------
G
Y
D
A
A
C
D
I
W
S
L
G
V
L
L
Y
T
M
L
T
G
Y
T
P
F
A
N
G
P
D
D
T
P
E
E
-
I
L
A
R
I
G
S
G
K
F
-
S
L
S
G
G
Y
W
N
S
V
S
D
T
A
K
D
L
V
S
K
M
L
H
V
D
P
H
Q
---
R
L
T
A
A
L
V
L
R
H
P
W
I
V
H
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
44.36
33%
-121
- C1 -
-
4ZLO
2
PAK1_HUMAN
A:
[26-188]
------------------------------------------------------------------------
E
K
I
G
Q
--
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
-----
N
------
K
K
E
L
--
I
I
N
E
I
L
V
M
R
E
-
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
----
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
-
S
L
T
D
V
V
T
E
T
-
C
-----
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
--
V
I
H
R
D
I
K
S
D
N
I
L
L
----
G
--
M
--
D
---
G
----
S
V
K
L
T
D
F
G
---------------
S
K
R
S
-----------------------------
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------