@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_26_0050: (2018-03-10 )
MDKYALGPVIGEGQFGSVRMATVKATGQTVAVKLLHVPRLTEGIPHPVARELLIASRVASPFLVKTIEIAPYGSHMAVVMERCMEDLACVLRKCSPAHPLPLLLTQSYMRMLLTALHALHSSGILHRDVKPSNCFVAVDGCLKLGDFGLSRPLCSDMSHEVVSRWYRAPELLFGQRRYGGEVDLWAAGCVFAELLRGHGRPFFTGDGDISQIAKIFDVFGTPTGGTCSFYRQLPDWEKVSFEEKKGTGLRVLLPFVPPEALDLLTKMLALDPASRCSAAEALSHPFFALSDILLRV
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70--........80........90....-....100.......110.......120.......130.....-..140.......150.---...---.-..160.......170.......180.......190.......200.......210.......220.......230.......240.......-250.......260.......270.......280.......290....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MDKYALGPVIGEGQFG
S
V
R
M
A
T
V
KATG
Q
T
V
A
V
K
L
L
HV
P
R
LTEGIP
H
P
V
A
R
E
L
L
I
A
S
RVAS
P
F
L
V
K
T
I
E
IAP--YG
S
H
M
A
V
V
M
E
R
C
M
E
D
L
A
C
V
L
R
KCS-PAHP
L
P
L
L
L
T
Q
S
Y
M
R
M
L
L
T
A
L
H
A
L
H
SSG
I
L
HRDVKPS
N
C
F
V
A
-
V
D
G
C
L
K
LGDFGLSR
P
L
---
C
S
D
---
M
-
S
H
E
V
V
S
R
W
YR
A
P
E
L
L
FGQRRYGGEV
D
L
W
A
A
G
C
V
F
A
E
L
L
R
GHGR
P
F
FTGDG
D
I
S
Q
I
A
K
I
F
D
VFGTPTG
G
T
C
S
F
Y
R
QLPDWEKVSFEEKKGTG
L
-
R
V
L
L
PFV
P
P
E
A
L
D
L
L
T
K
M
LALD
P
A
S
RC
S
A
A
E
A
LSH
P
F
F
A
L
S
D
I
L
LRV
17
PsiBlast_PDB
93.33
36%
-144
- C- -
-
1JVP
1
CDK2_HUMAN
P:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
--
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
-
D
A
S
-
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
--------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
--
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
S
F
P
K
W
A
R
Q
D
F
-
S
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
---------
9
PsiBlast_PDB
92.81
36%
-148
- C1 -
-
1CKP
2
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
--
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
-
D
A
S
-
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
---------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
--
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
S
F
P
K
W
A
R
Q
D
F
-
S
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
---------
11
PsiBlast_PDB
92.21
36%
-143
- C1 -
-
1DI8
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
--
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
-
D
A
S
-
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
--
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
S
F
P
K
W
A
R
Q
D
F
-
S
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
---------
1
PsiBlast_PDB
91.04
36%
-143
- C1 -
-
1GII
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
--
T
E
N
K
L
Y
L
V
F
E
H
V
H
Q
D
L
K
T
F
M
-
D
A
S
-
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
---------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
--
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
S
F
P
K
W
A
R
Q
D
F
-
S
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
---------
19
PsiBlast_PDB
90.92
36%
-143
- C1 -
-
1KE5
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
--
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
-
D
A
S
-
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
--------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
--
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
S
F
P
K
W
A
R
Q
D
F
-
S
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
---------
20
PsiBlast_PDB
90.47
36%
-144
- C1 -
-
1KE6
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
--
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
-
D
A
S
-
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
---------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
--
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
S
F
P
K
W
A
R
Q
D
F
-
S
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
---------
2
PsiBlast_PDB
89.16
36%
-140
- C1 -
-
1GIJ
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
--
T
E
N
K
L
Y
L
V
F
E
H
V
H
Q
D
L
K
T
F
M
-
D
A
S
-
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
E
G
A
I
K
L
A
D
F
G
L
A
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
--
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
S
F
P
K
W
A
R
Q
D
F
-
S
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
---------
10
PsiBlast_PDB
88.66
36%
-93
- C1 -
-
1BUH
-
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
-------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
--
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
-
D
A
S
-
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
GVP
V
R
T
---
Y
-
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
--
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
S
F
P
K
W
A
R
Q
D
F
-
S
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
---------
13
PsiBlast_PDB
87.50
36%
-104
- C1 -
-
1FVT
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
--
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
-
D
A
S
-
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G-------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
--
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
S
F
P
K
W
A
R
Q
D
F
-
S
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
---------
15
PsiBlast_PDB
86.57
36%
-98
- C1 -
-
1JSV
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
-----------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
--
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
-
D
A
S
-
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
GVP
V
R
T
---
Y
-
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
--
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
S
F
P
K
W
A
R
Q
D
F
-
S
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
---------
16
PsiBlast_PDB
86.56
36%
-139
- C1 -
-
1G5S
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
---------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
--
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
-
D
A
S
-
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
E
G
A
I
K
L
A
D
F
G
L
------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
--
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
S
F
P
K
W
A
R
Q
D
F
-
S
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
---------
4
PsiBlast_PDB
86.51
36%
-142
- C1 -
-
1OIT
1
CDK2_HUMAN
A:
[3-286]
--
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
-
G
E
V
V
A
L
K
K
I
-----------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
--
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
-
D
A
S
-
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
S
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
--
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
S
F
P
K
W
A
R
Q
D
F
-
S
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
---------
3
PsiBlast_PDB
85.72
36%
-91
- C1 -
-
2DS1
-
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
--
T
E
N
K
L
Y
L
V
F
E
H
V
H
Q
D
L
K
T
F
M
-
D
A
S
-
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
GVP
V
R
T
---
Y
-
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
--
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
S
F
P
K
W
A
R
Q
D
F
-
S
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
---------
18
PsiBlast_PDB
85.55
36%
-143
- C1 -
-
1GIH
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
--
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
-
D
A
S
-
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
E
G
A
I
K
L
A
D
F
G
L
A
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
--
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
S
F
P
K
W
A
R
Q
D
F
-
S
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
---------
6
PsiBlast_PDB
85.50
36%
-90
- C1 -
-
5UQ2
-
CDK2_HUMAN
A:
[4-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
--
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
-
D
A
S
-
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
GVP
V
R
T
---
Y
-
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
--
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
S
F
P
K
W
A
R
Q
D
F
-
S
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
---------
8
PsiBlast_PDB
84.77
36%
-92
- C1 -
-
1FIN
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
--
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
-
D
A
S
-
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
---
Y
-
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
--
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
-
K
P
S
F
P
K
W
A
R
Q
D
F
-
S
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
---------
32
HHSearch
84.27
34%
-83
- C1 -
-
1V0B
-
CDC2H_PLAFK
A:
[1-286]
M
E
K
Y
H
G
L
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
Q
N
N
-
Y
G
E
T
F
A
L
K
K
I
R
L
E
K
E
D
E
G
I
P
S
T
T
I
R
E
I
S
I
L
K
E
L
K
H
S
N
I
V
K
L
Y
D
V
I
H
--
T
K
K
R
L
V
L
V
F
E
H
L
D
Q
D
L
K
K
L
L
D
V
C
---
E
G
G
L
E
S
V
T
A
K
S
F
L
L
Q
L
L
N
G
I
A
Y
C
H
D
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
R
E
G
E
L
K
I
A
D
F
G
L
A
R
A
F
---
G
I
P
VRK
Y
-
T
H
E
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
T
I
D
I
W
S
V
G
C
I
F
A
E
M
V
N
G
--
A
P
L
F
P
G
V
S
E
A
D
Q
L
M
R
I
F
R
I
L
G
T
P
N
S
K
N
W
P
N
V
T
E
L
P
K
Y
D
P
N
-
F
T
V
Y
E
P
L
P
W
-
E
S
F
L
K
G
L
D
E
S
G
I
D
L
L
S
K
M
L
K
L
D
P
N
Q
R
I
T
A
K
Q
A
L
E
H
A
Y
F
K
E
-------
21
HHSearch
83.75
35%
-70
- C1 -
-
1UNL
1
CDK5_HUMAN
A:
[1-291]
M
Q
K
Y
E
K
L
E
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
R
E
T
H
E
I
V
A
L
K
R
V
R
L
D
D
D
D
E
G
V
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
H
K
N
I
V
R
L
H
D
V
L
H
--
S
D
K
K
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
S
C
---
N
G
D
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
R
N
G
E
L
K
L
A
N
F
G
L
A
R
A
F
---
G
I
P
VRC
Y
-
S
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
-
R
P
L
F
P
G
N
D
V
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
K
L
P
D
Y
K
P
Y
P
M
Y
-
P
A
T
T
S
L
-
V
N
V
V
P
K
L
N
A
T
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
S
D
F
C
P
----
31
HHSearch
83.72
36%
-89
- C1 -
-
5LQF
1
CDK1_HUMAN
D:
[6-294]
M
E
D
Y
T
K
I
E
K
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
K
T
T
G
Q
V
V
A
M
K
K
I
R
L
E
S
E
E
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
R
H
P
N
I
V
S
L
Q
D
V
L
M
--
Q
D
S
R
L
Y
L
I
F
E
F
L
S
M
D
L
K
K
Y
L
D
S
I
P
-
P
G
Q
Y
M
D
S
S
L
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
D
-
D
K
G
T
I
K
L
A
D
F
G
L
A
R
A
F
---
G
I
P
---
I
R-----
T
L
W
Y
R
S
P
E
V
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
T
K
--
K
P
L
F
H
G
D
S
E
I
D
Q
L
F
R
I
F
R
A
L
G
T
P
N
N
E
V
W
P
E
V
E
S
L
Q
D
Y
-
K
N
T
F
P
K
W
K
P
G
S
L
-
A
S
H
V
K
N
L
D
E
N
G
L
D
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
N
D
-------
40
HHSearch
83.62
35%
0
- C- -
-
3EB0
3
?
A:
[7-345]
-
K
K
Y
S
L
G
K
T
L
G
T
G
-
F
G
I
V
C
E
V
F
D
I
E
S
G
K
R
F
A
L
K
K
V
L
Q
D
P
------
R
Y
K
N
R
E
L
D
I
M
K
V
L
D
H
V
N
I
I
K
L
V
D
Y
F
Y
TT-
N
K
Y
L
N
V
I
M
E
Y
V
P
D
T
L
H
K
V
L
K
S
F
I
R
S
G
R
S
I
P
M
N
L
I
S
I
Y
I
Y
Q
L
F
R
A
V
G
F
I
H
S
L
G
I
C
H
R
D
I
K
P
Q
N
L
L
V
N
S
K
D
N
T
L
K
L
C
D
F
G
S
A
K
K
L
---
I
P
S
E
P
-
S
-
V
A
Y
I
C
S
R
F
Y
R
A
P
E
L
M
L
G
A
T
E
Y
T
P
S
I
D
L
W
S
I
G
C
V
F
G
E
L
I
L
G
--
K
P
L
F
S
G
E
T
S
I
D
Q
L
V
R
I
I
Q
I
M
G
T
P
T
K
E
Q
M
I
--
R
M
N
P
H
Y
--
V
R
F
P
T
L
K
A
K
D
W
R
K
I
L
P
E
G
T
P
S
L
A
I
D
L
L
E
Q
I
L
R
Y
E
P
D
L
R
I
N
P
Y
E
A
M
A
H
P
F
F
D
H
-------