@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_26_0950: (2018-03-10 )
MGPDCTAGGNGGGAHRYPPHRDVRGDEEASPRCPSPHRMRLQKQQCFQSSPENQQQQHPRALSSSNPGSPLMYTVCPATPDRSMNPYDRASPLYRSHASPHSRLGDSASPSSAMTEAGMYESNSDLSAVCPTWFNRCAASSPSLSSVMASRHLPPLQAHSPDPQSRCPQPFNSIAAAVSYSSPLGVASNESPHMKTALTSFGEASWGGLTSPNSNRGGMMASAPQQQSLGNCRSNVGHVMLPEEVSHPSKLAQSGMLNSSPSHSGGAGPARVSGASPYQCALDGLASQQQEKQQQSTLERYAPGNVTTPVGASSSAAAGGASPGSVPTGDADADKIVPRQHGDNNSLALNSSLEERLPTTAASVPHRHTSPSSVSWPRDAFASSPFSRDAPPSSHLHPRAAISPARESTPVMPLKTSPKTTSTPLRVDDSAPGGVEADCFSEARGSRASPPRPHAFSQHQSPEKGFIDSQSTGTPHPQPQPIHPLAPTSSSPQALKSPAMFGVIDLSYSRTDASGSNATPPMPTGATSVGASAVVKTRTQVRTPSRAPAVISVRVPVPSLPSNNSTPATSVNHADPTAAAASLSSTSAAATAVAPLNGGSSCSELTAHSGTTILRMVHSAGQRDSSYSTLHTTLSHSRDATTATATTTATTTPGYSPRADSQTPVHTATIASQHGTLFTPLSPLLAESDDDAVEAEQQQQQRKAVQSQQHMKSVASTALMAARVRKTAVSSPTVSVDAVRKPERSSQALTLTADTVLPVAVQEDEARCSSSAATTATRSSSNSRAQLSSSASLSRSINATTLTEPKGGTAGVAASGTGRLERVRTVVRAGSVSARNVASRERGPREKFAATFAASSSFSSKVAAAASSASASSMDMGAVAGARGAHVRRQTSVSTASTSSVASDMLRAPPALASYSFVSSRAQMQRYIDQWRDRFEEDKNAYKEGGYLTVTPGRIVHSRYVLIQKLGWGEFSTVWLGYDTKHATLGRGLSQAFVAVKVAKCRSNVQEATRYEVSLLRYLEARLPRHAAITNIIDCFDVRGEFGMHTCMVLPLCGPNLLSIIERMKADRSRRNAEDLRMIKEIVLSVLISLHELSELNVVHTDIKPENVLCSAVDSKLVNSMEKFCIYNQERSHMISVEDFKKSMAQQSTEQLVYLADFGLSALLEPPGSAQLWMSACSNVDASLLAPLMRCKKNFPVTRSGVVDNHRGTLIQTREYRAPEVLLGLDFTCTTDVWSVGCMTFELITGCFLMDPKRKTREPRDMDIEHLAMMMQILGPLPSEITSIRVRNNDYYDAIIQGTPVPKSGFRPPPEYLHRFVDRNGKFIYASRYHSYPRRNLEMELEPYLGFREAQLAANFILSCLHSYDPKKRPSAKKLLSHQWLYGVGAASKEKTPSR
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950...-.-...960.......970.......980.......990.......1000.---.....1010...---...---1020-----.---......-1030-......1040--...--.....1050......1060......1070......1080......1090-...-...1100......1110......1120......1130......1140........1150......1160......1170......1180......1190......1200-...--------.-....1210......1220.-.-....1230......1240...-------------...1250......1260......1270......1280......1290......1300......1310......1320.......1330......1340--.-.....1350......1360......1370......1380......1390..
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MGPDCTAGGNGGGAHRYPPHRDVRGDEEASPRCP
S
P
H
R
M
R
L
Q
K
Q
Q
C
FQSSPEN
Q
Q
Q
QHPRALSSSNPGS
P
L
M
Y
T
VCPATPDRSMNPYDRAS
P
L
Y
RSHAS
P
H
SRLGDSASPS
S
A
MTEAGMYESNS
D
L
S
A
V
C
P
T
W
F
N
R
CAASSP
S
L
S
S
V
M
A
SRHLPPLQAHSPDPQSRCPQ
P
F
N
S
I
A
A
A
VSYSSPLGVASNESP
H
M
K
T
A
L
T
SFGEASWGGLTSPNSNRGGMMASA
P
Q
Q
Q
S
L
G
N
C
R
SNVG
H
V
ML
P
E
EVS
H
P
S
K
L
A
QSGMLNSSPSHSGGAGPARVSGAS
P
Y
Q
C
A
L
D
G
L
A
S
Q
Q
Q
E
K
Q
Q
Q
S
T
L
E
R
YAPGNVTTPVGASSSAAAGGASPGSVPTGDA
D
A
D
KIVPRQHGDNN
S
L
ALN
S
S
L
E
E
RLPTTAASVPHRHTSPSSVSWP
R
D
AFASSPFSRDAPPSSHLHPRAAISPARESTPV
M
P
LKTSPKTTST
P
L
R
VDDSAPGGV
E
A
D
C
F
S
E
ARGSRASPPRPHAFSQHQSPEKGFIDSQSTGTPHPQPQPIHPLAPTSSS
P
Q
A
LKSPA
M
F
G
V
I
D
L
S
YSRTDASGSNATPPMPTGATSVGA
S
A
V
V
K
T
R
T
QVRTPSRA
P
A
V
I
S
V
RVPVPSLPSNNSTPATSVNHADP
T
A
A
A
ASLSSTSAA
A
T
A
V
A
PLNGGSS
C
S
E
LTAHS
G
T
T
I
L
R
M
V
H
SAGQRDSSY
S
T
L
H
T
T
LSHSRDAT
T
A
T
A
T
T
T
ATTTPGYSPRADSQTP
V
H
T
A
T
IASQHG
T
L
FT
P
L
S
P
L
LAESDD
D
A
V
E
A
E
Q
Q
Q
Q
Q
R
K
A
V
Q
S
Q
Q
H
M
K
S
V
A
S
T
A
L
M
A
A
R
V
R
K
TAVSSP
T
V
S
V
D
AVRKPERSS
Q
A
L
T
L
TAD
T
V
L
P
V
A
VQE
D
E
ARCSSSAA
T
T
A
TRSSSNSRAQLSSSASLSRSIN
A
T
T
LTEPKGGTAGVAASGT
G
R
L
E
R
V
R
T
V
V
R
AGSVS
A
R
N
V
A
S
RERG
P
R
E
K
F
A
A
T
FAASSSFS
S
K
V
A
AAASSASASSMD
M
G
AVAGARGA
H
V
R
R
Q
TSVSTAS
T
S
S
V
A
S
D
M
LRAPP
A
L
A
S
Y
S
F
V
S
S
R
A
Q
M
Q
R
Y
I
D
Q
W
R
D
R
F
E
E
D
K
N
A
Y
KEG
G
Y
L
T
VTPG
R
I
-
V
-
H
S
R
Y
V
L
I
Q
KLGWGE
F
S
T
V
W
L
GYDTK
H
A
T
L
G
R
G
L
S
Q
A
F
V
A
V
K
V
A
K
C
R
S
N
---
V
Q
E
A
T
R
Y
E
V
S
L
L
---
R
Y
L
---
E
A
R------L---P
R
H
A
A
I
-
T
N
I
I
-
D
C
F
DVRG--E--FG
M
--
H
T
C
M
V
LPLC
G
P
N
L
L
S
I
I
E
R
M
K
ADRSRR
N
A
E
D
L
R
M
I
K
E
I
V
L
S
V
L
I
S
L
H
E
L
-SEL-
N
V
V
HTDIKP
E
N
V
L
C
S
A
V
D
S
K
L
V
N
S
M
E
K
F
C
IYNQERS
H
M
I
S
V
E
D
F
--
K
K
S
M
A
Q
Q
S
T
E
Q
L
V
Y
L
A
D
F
G
L
S
A
LLEPPG
S
A
Q
L
W
M
S
A
CSNV
D
A
S
L
L
A
P
L
M
R
C
KKNFPVTRSG---VVD--------N-HR
G
T
L
I
Q
TREYRAP
E
V
L
L
G-L-D
F
T
CTTD
V
W
S
V
G
C
M
T
F
E
L
I
T
G
-------------
C
F
LMDPKRKTREPRDM
D
I
E
H
L
A
M
M
M
Q
I
LGPLPSE
I
T
S
I
R
V
RNNDYY
D
A
I
IQGTPVPKSGFRP
P
P
E
Y
L
H
R
F
V
DRNG-
K
F
I
Y
A
SRYHSYPRRN
L
E
M
E
LEP--Y-LG
F
R
E
A
Q
L
A
A
N
F
I
L
S
C
L
H
SYDPKKRP
S
A
K
K
L
L
S
HQ
W
L
YGVGAASKEKTPSR
3
PsiBlast_PDB
90.02
29%
0
- C- -
-
3BEG
-
A:
[12--3]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
K
I
G
D
L
-
F
-
N
G
R
Y
H
V
I
R
K
L
G
W
G
H
F
S
T
V
W
L
S
W
D
I
Q
--------
G
K
K
F
V
A
M
K
V
V
K
S
A
E
H
---
Y
T
E
T
A
L
D
E
I
R
L
L
---
K
S
V
R
NS
D
P
N
------
D
---
P
N
R
E
M
V
-
V
Q
L
L
-
D
D
F
K
I
S
G
--
V
--
N
G
T
--
H
I
C
M
V
F
E
V
L
G
H
H
L
L
K
W
I
-----
I
K
S
N
Y
Q
G
L
P
L
P
C
V
K
K
I
I
Q
Q
V
L
Q
G
L
D
Y
L
H
T
K
C
-
R
I
I
H
T
D
I
K
P
E
N
I
L
L
S
------
V
N
------------------
E
Q
Y
--
I
R
R
L
A
A
E
A
-------------------------------
A
G
N
F
L
V
N
P
L
E
--
P
K
N
A
E
K
L
K
V
K
---
I
A
D
LGNACWVH
K
-
H
F
T
E
D
I
Q
T
R
Q
Y
R
S
L
E
V
L
I
G
-
S
-
G
Y
N
T
P
A
D
I
W
S
T
A
C
M
A
F
E
L
A
T
G
-------------
D
Y
L
F
E
P
H
S
G
E
E
Y
T
R
D
E
D
--
H
I
A
L
I
I
E
L
L
G
K
V
P
R
K
L
-------------
I
V
A
G
------------
K
Y
S
K
E
F
F
T
K
K
G
-
D
L
K
H
I
T
K
L
K
--
P
W
G
L
F
E
V
L
V
E
K
--
Y
E
W
S
Q
E
E
A
A
G
F
T
D
F
L
L
P
M
L
E
L
I
-
P
E
K
R
A
T
A
A
E
C
L
R
H
P
W
L
--------------
5
PsiBlast_PDB
74.04
28%
-48
- C1 -
-
2X7G
7
SRPK2_HUMAN
A:
[22-387]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
V
K
I
G
D
L
-
F
-
N
G
R
Y
H
V
I
R
K
L
G
W
G
H
F
S
T
V
W
L
C
W
D
M
Q
--------
G
K
R
F
V
A
M
K
V
V
K
S
A
Q
H
---
Y
T
E
T
A
L
D
E
I
K
L
L
K
C
V
R
E
S
---
D
P
S
------
D
---
P
N
K
D
M
V
-
V
Q
L
I
-
D
D
F
K
I
S
G
--
M
--
N
G
I
--
H
V
C
M
V
F
E
V
L
G
H
H
L
L
K
W
I
-----
I
K
S
N
Y
Q
G
L
P
V
R
C
V
K
S
I
I
R
Q
V
L
Q
G
L
D
Y
L
H
S
K
C
-
K
I
I
H
T
D
I
K
P
E
N
I
L
M
C
V
D
D
A
------------------------
Y
--
V
R
R
M
A
A
E
--------------------------------
L
L
V
N
P
L
D
P
R
N
A
D
K
I
R
V
K
I
A
D
L
G
NAC
W
V
H
--------
K
-
H
F
T
E
D
I
Q
T
R
Q
Y
R
S
I
E
V
L
I
G
-
A
-
G
Y
S
T
P
A
D
I
W
S
T
A
C
M
A
F
E
L
A
T
G
-------------
D
Y
L
F
E
P
H
S
G
E
D
Y
S
R
D
E
D
--
H
I
A
H
I
I
E
L
L
G
S
I
P
R
H
-------------------------
F
A
L
S
G
K
Y
S
R
E
F
F
N
R
R
G
-
E
L
R
H
I
T
K
L
K
P
W
S
L
F
D
V
L
V
E
K
Y
G
--
W
-
P
H
E
D
A
A
Q
F
-
T
D
F
L
I
P
M
L
E
M
V
-
P
E
K
R
A
S
A
G
E
C
L
R
H
P
W
L
--------------
4
PsiBlast_PDB
73.68
29%
-12
- C1 -
-
5MY8
24
?
A:
[9-381]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
G
Y
H
L
V
K
I
G
D
L
-
F
-
N
G
R
Y
H
V
I
R
K
L
G
W
G
H
F
S
T
V
W
L
S
W
D
I
Q
--------
G
K
K
F
V
A
M
K
V
V
K
S
A
E
H
---
Y
T
E
T
A
L
D
E
I
R
L
L
---
K
S
V
R
N
S
D
P
N
------
D
---
P
N
R
E
M
V
-
V
Q
L
L
-
D
D
F
K
I
S
G
--
V
--
N
G
T
--
H
I
C
M
V
F
E
V
L
G
H
H
L
L
K
W
I
-----
I
K
S
N
Y
Q
G
L
P
L
P
C
V
K
K
I
I
Q
Q
V
L
Q
G
L
D
Y
L
H
T
K
C
-
R
I
I
H
T
D
I
K
P
E
N
I
L
L
S
------
V
N
------------------
E
Q
Y
--
I
R
R
L
A
A
E
A
T
E
W
Q
R
-----------------------------
F
L
V
N
P
L
E
--
P
K
N
A
E
K
L
K
V
K
---
I
A
D
LGNACWVH
K
-
H
F
T
E
D
I
Q
T
R
Q
Y
R
S
L
E
V
L
I
G
-
S
-
G
Y
N
T
P
A
D
I
W
S
T
A
C
M
A
F
E
L
A
T
G
-------------
D
Y
L
F
E
P
H
S
G
E
E
Y
T
R
D
E
D
--
H
I
A
L
I
I
E
L
L
G
K
V
P
R
K
L
-------------
I
V
A
G
------------
K
Y
S
K
E
F
F
T
K
K
G
-
D
L
K
H
I
T
K
L
K
--
P
W
G
L
F
E
V
L
V
E
K
--
Y
E
W
S
Q
E
E
A
A
G
F
T
D
F
L
L
P
M
L
E
L
I
-
P
E
K
R
A
T
A
A
E
C
L
R
H
P
W
L
--------------
21
HHSearch
73.28
31%
-27
- C1 -
-
5MY8
24
?
A:
[9-383]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
G
Y
H
L
V
K
I
G
D
L
-
F
-
N
G
R
Y
H
V
I
R
K
L
G
W
G
H
F
S
T
V
W
L
S
W
D
I
Q
--------
G
K
K
F
V
A
M
K
V
V
K
S
A
E
H
---
Y
T
E
T
A
L
D
E
I
R
L
L
---
K
S
V
---
R
N
S
------
D
PND
P
N
R
E
M
V
-
V
Q
L
L
-
D
D
F
K
I
S
G
--
V
--
N
G
T
--
H
I
C
M
V
F
E
V
L
G
H
H
L
L
K
W
I
I
K
S
N
Y
-----
Q
G
L
P
L
P
C
V
K
K
I
I
Q
Q
V
L
Q
G
L
D
Y
L
-
H
T
K
C
R
I
I
H
T
D
I
K
P
E
N
I
L
L
S
V
N
E
Q
Y
I
R
R
L
A
A
E
A
T
E
W
Q
R
----------
F
LV
N
P
L
E
P
K
N
A
E
K
L
K
V
K
I
A
D
L
G
N
A
C
W
V
H
K
H
---------------------------------------------------
F
T
E
D
I
Q
T
R
Q
Y
R
S
L
E
V
L
I
G
-
S
-
G
Y
N
T
P
A
D
I
W
S
T
A
C
M
A
F
E
L
A
T
G
-------------
D
Y
L
F
E
P
H
S
G
E
--
E
Y
T
R
D
E
D
H
I
A
L
I
I
E
L
L
G
K
V
P
R
K
L
I
V
A
G
K
Y
S
K
E
F
F
T
K
K
---------------
G
D
L
K
H
I
-
T
-------------
K
L
K
P
W
G
L
F
E
V
L
V
E
KY
E
-
W
S
Q
E
E
A
A
G
F
T
D
F
L
L
P
M
L
-
E
L
I
P
E
K
R
A
T
A
A
E
C
L
R
H
P
W
L
N
S
------------
12
PsiBlast_PDB
72.55
26%
-41
- C1 -
-
3NR9
1
CLK2_HUMAN
A:
[21-351]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
H
L
I
Y
H
V
G
D
W
-
L
-
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
H
R
-----
R
G
--
G
A
R
V
A
L
K
I
I
K
N
V
E
K
---
Y
K
E
A
A
R
L
E
I
N
V
L
---
E
K
I
---
N
E
K
------
D
---
P
D
N
K
N
L
C
V
Q
M
F
-
D
W
F
D
Y
H
G
----------
H
M
C
I
S
F
E
L
L
G
---
L
S
T
F
D
F
L
K
D
N
N
Y
L
--
P
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
-
H
D
N
-
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
D
Y
E
L
T
----------
D
E
R
S
----------
V
K
S
T
A
-------
V
R
V
V
D
F
G
----------------------------------------
S
A
---
T
F
D
--------
H
E
H
H
S
T
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
-
L
-
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
-------------
F
T
L
F
----
Q
T
H
D
N
R
----
E
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
R
K
T
R
K
Q
K
Y
F
Y
R
G
R
L
D
W
D
E
N
T
S
A
G
---------
R
Y
V
R
E
N
C
-
K
P
L
---------
R
R
Y
L
T
S
E
A
E
---------
E
H
H
Q
L
F
D
L
I
E
S
M
L
E
-
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
--------------
6
PsiBlast_PDB
71.13
28%
-46
- C1 -
-
5MYV
2
SRPK2_HUMAN
A:
[20-387]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
H
P
V
K
I
G
D
L
-
F
-
N
G
R
Y
H
V
I
R
K
L
G
W
G
H
F
S
T
V
W
L
C
W
D
M
Q
--------
G
K
R
F
V
A
M
K
V
V
K
S
A
Q
H
---
Y
T
E
T
A
L
D
E
I
K
L
L
K
C
V
R
E
S
---
D
P
S
------
D
---
P
N
K
D
M
V
-
V
Q
L
I
-
D
D
F
K
I
S
G
--
M
--
N
G
I
--
H
V
C
M
V
F
E
V
L
G
H
H
L
L
K
W
I
-----
I
K
S
N
Y
Q
G
L
P
V
R
C
V
K
S
I
I
R
Q
V
L
Q
G
L
D
Y
L
H
S
K
C
-
K
I
I
H
T
D
I
K
P
E
N
I
L
M
C
V
D
D
A
------------------------
Y
--
V
R
R
M
A
A
E
A
T
E
W
Q
--------
K
------------------
L
L
V
N
P
L
D
P
R
N
A
D
K
I
R
V
K
I
A
D
L
G
NAC
W
V
H
--------
K
-
H
F
T
E
D
I
Q
T
R
Q
Y
R
S
I
E
V
L
I
G
-
A
-
G
Y
S
T
P
A
D
I
W
S
T
A
C
M
A
F
E
L
A
T
G
-------------
D
Y
L
F
E
P
H
S
G
E
D
Y
S
R
D
E
D
--
H
I
A
H
I
I
E
L
L
G
S
I
P
R
H
-------------------------
F
A
L
S
G
K
Y
S
R
E
F
F
N
R
R
G
-
E
L
R
H
I
T
K
L
K
P
W
S
L
F
D
V
L
V
E
K
Y
G
--
W
-
P
H
E
D
A
A
Q
F
-
T
D
F
L
I
P
M
L
E
M
V
-
P
E
K
R
A
S
A
G
E
C
L
R
H
P
W
L
--------------
1
PsiBlast_PDB
70.90
29%
-11
- C1 -
-
1WAK
5
SRPK1_HUMAN
A:
[22-395]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
K
--
Y
H
L
V
K
I
G
D
L
-
F
-
N
G
R
Y
H
V
I
R
K
L
G
W
G
H
F
S
T
V
W
L
S
W
D
I
Q
--------
G
K
K
F
V
A
M
K
V
V
K
S
A
E
H
---
Y
T
E
T
A
L
D
E
I
R
L
L
---
K
S
V
R
N
S
D
P
N
------
D
---
P
N
R
E
M
V
-
V
Q
L
L
-
D
D
F
K
I
S
G
--
V
--
N
G
T
--
H
I
C
M
V
F
E
V
L
G
H
H
L
L
K
W
I
-----
I
K
S
N
Y
Q
G
L
P
L
P
C
V
K
K
I
I
Q
Q
V
L
Q
G
L
D
Y
L
H
T
K
C
-
R
I
I
H
T
D
I
K
P
E
N
I
L
L
S
------
V
N
------------------
E
Q
Y
--
I
R
R
L
A
A
E
A
------------------------------
T
A
G
N
F
L
V
N
P
L
E
--
P
K
N
A
E
K
L
K
V
K
---
I
A
D
LGNACWVH
K
-
H
F
T
E
D
I
Q
T
R
Q
Y
R
S
L
E
V
L
I
G
-
S
-
G
Y
N
T
P
A
D
I
W
S
T
A
C
M
A
F
E
L
A
T
G
-------------
D
Y
L
F
E
P
H
S
G
E
E
Y
T
R
D
E
D
--
H
I
A
L
I
I
E
L
L
G
K
V
P
R
K
L
-------------
I
V
A
G
------------
K
Y
S
K
E
F
F
T
K
K
G
-
D
L
K
H
I
T
K
L
K
--
P
W
G
L
F
E
V
L
V
E
K
--
Y
E
W
S
Q
E
E
A
A
G
F
T
D
F
L
L
P
M
L
E
L
I
-
P
E
K
R
A
T
A
A
E
C
L
R
H
P
W
L
--------------
2
PsiBlast_PDB
70.18
29%
-7
- C1 -
-
4WUA
2
?
A:
[32-399]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
K
I
G
D
L
-
F
-
N
G
R
Y
H
V
I
R
K
L
G
W
G
H
F
S
T
V
W
L
S
W
D
I
Q
--------
G
K
K
F
V
A
M
K
V
V
K
S
A
E
H
---
Y
T
E
T
A
L
D
E
I
R
L
L
---
K
S
V
R
NS
D
P
N
------
D
---
P
N
R
E
M
V
-
V
Q
L
L
-
D
D
F
K
I
S
G
--
V
--
N
G
T
--
H
I
C
M
V
F
E
V
L
G
H
H
L
L
K
W
I
-----
I
K
S
N
Y
Q
G
L
P
L
P
C
V
K
K
I
I
Q
Q
V
L
Q
G
L
D
Y
L
H
T
K
C
-
R
I
I
H
T
D
I
K
P
E
N
I
L
L
S
------
V
N
------------------
E
Q
Y
--
I
R
R
L
A
A
E
A
T
-----------------------------------
V
N
P
L
E
--
P
K
N
A
E
K
L
K
V
K
---
I
A
D
LGNACWVH
K
-
H
F
T
E
D
I
Q
T
R
Q
Y
R
S
L
E
V
L
I
G
-
S
-
G
Y
N
T
P
A
D
I
W
S
T
A
C
M
A
F
E
L
A
T
G
-------------
D
Y
L
F
E
P
H
S
G
E
E
Y
T
R
D
E
D
--
H
I
A
L
I
I
E
L
L
G
K
V
P
R
K
L
-------------
I
V
A
G
------------
K
Y
S
K
E
F
F
T
K
K
G
-
D
L
K
H
I
T
K
L
K
--
P
W
G
L
F
E
V
L
V
E
K
--
Y
E
W
S
Q
E
E
A
A
G
F
T
D
F
L
L
P
M
L
E
L
I
-
P
E
K
R
A
T
A
A
E
C
L
R
H
P
W
L
--------------
7
PsiBlast_PDB
65.77
28%
-51
- C1 -
-
2EU9
1
A:
[2-272]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
D
K
E
-----
G
H
L
V
C
R
I
G
D
W
-
L
-
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
--
H
A
---
R
G
K
S
Q
--
V
A
L
K
I
I
R
N
V
G
K
---
Y
R
E
A
A
R
L
E
I
N
V
L
---
K
K
I
---
K
E
K
------
D
---
K
E
N
K
F
L
-
C
V
L
M
S
D
W
F
N
F
H
G
----------
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
-----
N
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
-
H
E
N
-
Q
L
T
H
T
D
L
K
P
E
N
I
L
-------
F
V
N
S
-
E
F
E
T
L
Y
N
E
H
-
S
C
E
--------
E
K
S
V
K
N
T
S
----
I
R
V
A
D
F
G
----------------------------------------
S
A
---
T
F
D
--------
H
E
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
-
L
-
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
-------------
F
T
L
F
----
Q
T
H
E
N
R
----
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
H
-
R
T
R
K
Q
K
Y
F
-----------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
65.68
28%
-57
- C1 -
-
2WU6
7
CLK3_HUMAN
A:
[34-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
D
K
E
-----
G
H
L
V
C
R
I
G
D
W
-
L
-
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
--
H
A
---
R
G
K
S
Q
--
V
A
L
K
I
I
R
N
V
G
K
---
Y
R
E
A
A
R
L
E
I
N
V
L
---
K
K
I
---
K
E
K
------
D
---
K
E
N
K
F
L
-
C
V
L
M
S
D
W
F
N
F
H
G
----------
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
-----
N
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
-
H
E
N
-
Q
L
T
H
T
D
L
K
P
E
N
I
L
-------
F
V
N
S
-
E
F
E
T
L
Y
N
E
H
K
S
C
E
--------
E
K
S
V
K
N
T
S
----
I
R
V
A
D
F
G
----------------------------------------
S
A
---
T
F
D
--------
H
E
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
-
L
-
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
-------------
F
T
L
F
----
Q
T
H
E
N
R
----
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
H
-
R
T
R
K
Q
K
Y
F
-----------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
64.35
28%
-55
- C1 -
-
3RAW
1
CLK3_HUMAN
A:
[34-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
D
K
E
-----
G
H
L
V
C
R
I
G
D
W
-
L
-
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
--
H
A
---
R
G
K
S
Q
--
V
A
L
K
I
I
R
N
V
G
K
---
Y
R
E
A
A
R
L
E
I
N
V
L
---
K
K
I
---
K
E
K
------
D
---
K
E
N
K
F
L
-
C
V
L
M
S
D
W
F
N
F
H
G
----------
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
-----
N
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
-
H
E
N
-
Q
L
T
H
T
D
L
K
P
E
N
I
L
-------
F
V
N
S
-
E
F
E
T
L
Y
N
E
H
K
S
C
E
--------
E
K
S
V
K
N
T
S
----
I
R
V
A
D
F
G
----------------------------------------
S
A
---
T
F
D
--------
H
E
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
-
L
-
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
-------------
F
T
L
F
----
Q
T
H
E
N
R
----
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
H
-
R
T
R
K
Q
K
Y
F
-----------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
63.17
28%
-51
- C1 -
-
2WU7
1
CLK3_HUMAN
A:
[34-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
D
K
E
-----
G
H
L
V
C
R
I
G
D
W
-
L
-
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
--
H
A
---
R
G
K
S
Q
--
V
A
L
K
I
I
R
N
V
G
K
---
Y
R
E
A
A
R
L
E
I
N
V
L
---
K
K
I
---
K
E
K
------
D
---
K
E
N
K
F
L
-
C
V
L
M
S
D
W
F
N
F
H
G
----------
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
-----
N
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
-
H
E
N
-
Q
L
T
H
T
D
L
K
P
E
N
I
L
-------
F
V
N
S
-
E
F
E
T
L
Y
N
E
H
K
S
C
E
--------
E
K
S
V
K
N
T
S
----
I
R
V
A
D
F
G
----------------------------------------
S
A
---
T
F
D
--------
H
E
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
-
L
-
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
-------------
F
T
L
F
----
Q
T
H
E
N
R
----
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
H
-
R
T
R
K
Q
K
Y
F
-----------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
59.70
24%
-24
- C1 -
-
3LLT
1
?
A:
[30-359]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
M
L
-
L
-
N
N
A
F
L
V
I
R
K
M
G
D
G
T
F
G
R
V
L
L
---
C
Q
H
I
D
-----
N
K
K
Y
Y
A
V
K
V
V
R
N
I
K
K
---
Y
T
R
S
A
K
I
E
A
D
I
L
---
K
K
I
---
Q
N
D
------
D
---
I
N
N
N
N
I
-
V
K
-------
Y
H
G
--
K
--
F
M
Y
YD
H
M
C
L
I
F
E
P
L
G
P
S
L
Y
E
I
I
T
R
-----
N
N
Y
N
G
F
H
I
E
D
I
K
L
Y
C
I
E
I
L
K
A
L
N
Y
L
-
R
K
M
-
S
L
T
H
T
D
L
K
P
E
N
I
L
---
L
D
D
P
Y
---
F
E
K
S
L
I
T
V
R
R
------
V
T
D
G
--
K
K
I
Q
I
Y
R
T
K
S
T
G
I
K
L
I
D
F
G
-----------------
C
A
T
F
K
S
---------------------------------
D
-
Y
H
G
S
I
I
N
T
R
Q
Y
R
A
P
E
V
I
L
N
-
L
-
G
W
D
V
S
S
D
M
W
S
F
G
C
V
L
A
E
L
Y
T
G
-------------
S
L
L
F
----
R
T
H
E
----
H
M
E
H
L
A
M
M
E
S
I
I
Q
P
I
P
K
N
M
L
Y
E
A
T
K
T
N
G
-----------------------
S
K
Y
V
N
K
D
E
L
K
L
A
W
P
E
N
A
S
S
I
N
S
I
K
H
V
K
K
C
L
P
--
L
-
Y
K
I
I
K
H
E
L
F
C
D
F
L
Y
S
I
L
Q
-
I
D
P
T
L
R
P
S
P
A
E
L
L
K
H
K
F
L
--------------
35
HHSearch
58.79
28%
-120
- C1 -
-
3LLT
1
?
A:
[26-261]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
K
K
G
M
L
-
L
-
N
N
A
F
L
V
I
R
K
M
G
D
G
T
F
G
R
V
L
L
C
Q
H
I
D
--------
N
K
K
Y
Y
A
V
K
V
V
R
N
I
K
K
---
Y
T
R
S
A
K
I
E
A
D
I
L
---
K
K
I
---
Q
N
D
------
D
---
I
N
N
N
N
I
-
V
K
Y
H
-
G
K
F
M
Y
Y
--------
D
--
H
M
C
L
I
F
E
P
L
G
P
S
L
Y
E
I
I
T
R
N
N
Y
-----
N
G
F
H
I
E
D
I
K
L
Y
C
I
E
I
L
K
A
L
N
Y
L
-
R
K
M
-
S
L
T
H
T
D
L
K
P
E
N
I
L
L
D
D
P
Y
F
E
K
S
--
L
I
T
V
R
R
-
V
T
D
------
G
K
-----
K
I
Q
I
Y
R
T
K
S
T
G
I
K
L
I
D
F
G
C
A
T
F
K
S
D
Y
---------------------------------------------------
H
G
S
I
I
N
T
R
Q
Y
R
A
P
E
V
I
L
N
-
L
-
G
W
D
V
S
S
D
M
W
S
F
G
C
V
L
A
E
L
Y
T
G
-------------
S
L
L
F
R
T
---------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
55.38
39%
-18
- C1 -
-
1Q99
2
SKY1_YEAST
B:
[5-237]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
Y
H
P
A
F
K
G
E
P
-
Y
K
D
A
R
Y
I
L
V
R
K
L
G
W
G
H
F
S
T
V
W
L
A
K
D
M
V
--------
N
N
T
H
V
A
M
K
I
V
R
G
D
K
V
---
Y
T
E
A
A
E
D
E
I
K
L
L
---
Q
R
V
---
N
D
A
DNT
K
E
D
S
---
M
G
A
N
H
I
-
L
K
L
L
-
D
H
F
N
H
K
G
--
P
--
N
G
V
--
H
V
V
M
V
F
E
V
L
G
E
N
L
L
A
L
I
K
K
Y
E
H
R
-----
G
I
P
L
I
Y
V
K
Q
I
S
K
Q
L
L
L
G
L
D
Y
M
-
H
R
R
C
G
I
I
H
T
D
I
K
P
E
N
V
L
M
E
I
V
D
S
---------------------------------
P
E
N
L
I
Q
I
K
I
A
D
L
G
N
A
C
W
Y
D
E
H
---------------------------------------------------
Y
T
N
S
I
Q
T
R
E
Y
R
S
P
E
V
L
L
G
-
A
-
P
W
G
C
G
A
D
I
W
S
T
A
C
L
I
F
E
L
I
T
G
-------------
D
F
L
F
E
P
---------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
55.13
24%
-44
- C1 -
-
5BYZ
7
MK07_HUMAN
A:
[4-309]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-
G
D
E
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
R
L
--------
T
G
Q
Q
V
A
I
K
K
I
P
N
A
F
D
V
V
T
N
A
K
R
T
L
R
E
L
K
I
L
---
K
H
F
-----------------
K
H
D
N
I
-
I
A
I
K
-
D
I
L
R
P
T
V
PY
G
--
E
F
K
--
S
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
H
S
S
Q
-------
P
L
T
L
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
-
H
S
A
-
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
E
---------------------------------------
N
C
E
L
K
I
G
D
F
G
M
A
R
G
L
C
T
S
P
A
E
-----------------------------------
H
Q
--------
Y
-
F
M
T
E
Y
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
H
-
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
R
-------------
R
Q
L
F
P
G
K
N
--------
Y
V
H
Q
L
Q
L
I
M
M
V
L
G
T
P
S
P
A
V
I
Q
A
V
G
A
--
E
R
V
R
-----------------
A
Y
I
Q
S
L
P
P
R
Q
-------------
P
-
V
P
W
E
T
--------
V
Y
P
G
A
D
R
Q
A
L
S
L
L
G
R
M
L
-
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
Y
H
D
P
D
D
E
-----
36
HHSearch
54.60
39%
-12
- C1 -
-
1Q8Y
1
?
B:
[9-237]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
F
K
G
E
P
Y
K
-
D
A
R
Y
I
L
V
R
K
L
G
---
F
S
T
V
W
L
A
K
D
M
V
--------
N
N
T
H
V
A
M
K
I
V
R
G
D
K
V
---
Y
T
E
A
A
E
D
E
I
K
L
L
---
Q
R
V
---
N
D
A
DNT
K
E
D
S
---
M
G
A
N
H
I
-
L
K
L
L
-
D
H
F
N
H
K
G
--
P
--
N
G
V
--
H
V
V
M
V
F
E
V
L
G
E
N
L
L
A
L
I
K
K
Y
E
H
R
-----
G
I
P
L
I
Y
V
K
Q
I
S
K
Q
L
L
L
G
L
D
Y
M
-
H
R
R
C
G
I
I
H
T
D
I
K
P
E
N
V
L
M
E
I
V
D
S
---------------------------------
P
E
N
L
I
Q
I
K
I
A
D
L
G
N
A
C
W
Y
D
E
H
---------------------------------------------------
Y
T
N
S
I
Q
T
R
E
Y
R
S
P
E
V
L
L
G
-
A
-
P
W
G
C
G
A
D
I
W
S
T
A
C
L
I
F
E
L
I
T
G
-------------
D
F
L
F
E
P
---------------------------------------------------------------------------------------------------------------------------------------------------
50
Fugue
52.86
21%
-119
- C1 -
-
1BYG
1
CSK_HUMAN
A:
[15-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
W
A
L
-
N
-
M
K
E
L
K
L
L
Q
T
I
G
K
G
E
F
G
D
V
M
L
G
D
Y
R
G
----------
N
K
V
A
V
K
C
I
K
--------
N
D
A
Q
A
F
L
A
E
A
S
---
V
M
T
---
Q
--------
L
----
R
H
S
N
L
-
V
Q
L
L
-
G
V
I
V
--
E
------
E
G
--
L
Y
I
V
T
E
Y
M
A
K
G
S
L
V
D
Y
L
R
S
R
G
-----
R
S
V
L
G
G
D
C
L
L
K
F
S
L
D
V
C
E
A
M
E
Y
L
-
E
G
N
-
N
F
V
H
R
D
L
A
A
R
N
V
L
V
S
---------------------------------------
E
D
N
V
A
K
V
S
D
F
G
---------------------------------------------------------------
L
L
P
V
K
W
T
A
P
E
A
L
R
E
-
K
-
K
F
S
T
K
S
D
V
W
S
F
G
I
L
L
W
E
I
Y
S
F
GRVPYPRIPLKD
V
V
P
R
V
E
K
G
Y
K
M
D
A
P
D
G
C
P
P
A
V
Y
E
V
M
K
N
C
W
H
L
D
A
A
M
R
P
S
F
L
Q
L
R
E
Q
L
E
H
I
K
T
H
E
L
----------------------------------------------------------------------------------------------------
23
HHSearch
52.38
23%
-47
* C1 *
-
1J1B
1
GSK3B_HUMAN
B:
[53-345]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
--------
S
G
E
L
V
A
I
K
K
V
L
Q
D
K
------
R
F
K
N
R
E
L
Q
I
M
---
R
K
L
-----------------
D
H
C
N
I
-
V
R
L
R
-
Y
F
F
Y
S
S
G
--
E
KK
D
E
V
--
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
---
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
-
H
S
F
-
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
--------------------------------------
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
-------------------------------------------------
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
-
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
-------------
Q
P
I
F
P
G
D
S
--------
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
--
N
-
Y
T
-----------------
E
F
---
K
F
P
Q
-------------
I
K
A
H
P
W
T
K
------
V
-
F
R
P
R
T
P
P
E
A
I
A
L
C
S
R
L
L
-
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
---------
22
HHSearch
51.57
30%
-87
- C1 -
-
4AZF
1
DYRK2_HUMAN
A:
[94-303]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
-
V
-
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
H
K
--------
V
H
Q
H
V
A
L
K
M
V
R
N
E
K
R
---
F
H
R
Q
A
A
E
E
I
R
I
L
---
E
H
L
---
R
K
Q
D
-----
K
---
D
N
T
M
N
V
-
I
H
M
L
-
E
N
F
T
F
--------
R
N
--
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
K
F
-----
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
-
H
K
N
-
R
I
I
H
C
D
L
K
P
E
N
I
L
L
K
Q
Q
G
-------------------------------------
R
S
G
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
R
---------------------------------------------------
V
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
-
A
-
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
-------------
Y
P
L
L
P
G
---------------------------------------------------------------------------------------------------------------------------------------------------