@TOME V2.3
(Mar 2018)
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_27_0100: (2018-03-10 )
MDKYEILAQIGDGTFGSVAKAVSKKTGQLVAIKKMKQKFYTWEECVKLPEVDVVRRIHGHPNVVKLREVIRENNELFFVFEYMDGDLLGVIKKAKQQGGPPASTPSAAPLIPYPLVKNYMRQMLQALVYIHKRGYFHRDMKPENLLIRKEASGDEVLKLADFGLVKEICARPPFTDYVSTRWYRAPELLLQDRFYGAAVDVWAAGCIMAELITMRPLFPGTNEVDQLFKIMSVLGSPTEEVWAGGLRLAKKIRYTFPKVAGSGLAQALPSHIPLPALDLLRQMLVYDPKVRLTAEQCLQHPFFNVGIDECNAPSAAALDQLALMAKRMLPGSKTAPPALKSPTAGQVAALKAARASTDASLSDTSSRKFYLLGTLKDPAPSLPKLPVALSTSPPSLDAPPNASSPLRGRGALSPAGMPVLANGHQCPSLTTTVAKGKRRSQETADTSLAKKLAGLKNVPTGKGKLPVSYALPAASAVHSPRAAPNLKVSASVARPYPLAPTANNRDAVASPRHHNPYKEAETTSPTAASAAAKVEIDLDELMEEFASEMTAMGVLAQRHDSGASAESKSESYVSQPALPPDPVATLLNNSRYRRKSTTSADPLLKGNNSPRATHQLDTRKVDDVAAKSDLPRIDHSAPKGMSPSLKALLAKHKTSGLAFP
Atome Classification :
(24 SA)
------------------------------------------------------------------------.........10........20........30....-....40.-....---...50........60........70------........80...-.....90........100.......110.......120.......130.......140.......150.......160.......170.-----.....---..--180.......190.----......200.......210.......220.......230.......240.....-..250.......260.......270..--.....280.......290---.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
------------------------------------------------------------------------M
D
K
Y
E
I
L
A
QIGDG
T
F
G
S
V
A
K
A
V
S
KKTGQ
L
V
A
I
K
K
M
-
K
Q
KFY
T
W
-
E
E
C
V---KLP
E
V
D
V
V
R
R
IHGHP
N
V
V
K
L
R
E
V
I
R
------ENN
E
L
F
F
V
F
EYMD-G
D
L
L
G
V
I
K
K
A
K
QQGGPPASTPSAAPLI
P
Y
P
L
V
K
N
Y
M
R
Q
M
L
Q
A
L
V
Y
I
H
KRGYFHRDMKPE
N
L
L
I
R
KEASGD
E
V
L
K
L
A
D
F
G
L
V
K
E
I
CA-RP-----P
F
T
D
Y
---
V
S--TRWYR
A
P
E
L
L
L
QDR----FYG
A
A
V
D
V
W
A
A
G
C
I
M
A
E
L
I
TMRPLFPG
T
N
E
V
D
Q
L
F
K
I
M
S
V
LGS
P
T
E
E
V
W
A
G
G
L
R
-
L
A
K
K
I
R
Y
TFPKVA
G
S
G
L
A
Q
A
L
PSHIPL--
P
A
L
D
L
L
R
Q
M
LVYDPK
V
R
L---
T
A
E
Q
C
LQHPFFNVGIDECNAP
S
A
A
A
L
D
Q
L
A
L
M
A
K
R
MLPGSKTAPPALKSPTAG
Q
V
A
A
L
K
A
ARASTDASLSDTSS
R
K
F
Y
L
L
G
TLKDPAPSLPKL
P
V
A
LSTSPPSLDAPPNASSPLRGRGALSPAG
M
P
V
LANGHQCP
S
L
T
T
T
V
A
KGKRRSQETA
D
T
S
L
A
K
K
L
AGLKNVPTGKG
K
L
P
V
S
YALP
A
A
S
AVHSPRAAPN
L
K
V
S
ASVARPYPLAPTANNRDAVASPRHHNPYKEAETTSPTAAS
A
A
A
K
V
E
I
D
L
D
E
L
M
E
E
F
A
S
E
M
T
A
M
G
V
L
A
QRHDSGASAESK
S
E
SYVSQPALP
P
D
P
V
A
T
L
LNNSRYRRKSTTSADPLLKGNNSPRATHQLDTR
K
V
D
D
V
AAKSDLPRIDHSAPKGM
S
P
S
L
K
A
L
L
A
KHKTSGLAFP
40
HHSearch
76.58
37%
-134
- C1 -
-
3GC0
1
?
A:
[33-324]
------------------------------------------------------------------------
I
D
R
Y
R
R
I
T
K
L
G
E
G
T
Y
G
E
V
Y
K
A
I
D
T
V
T
N
E
T
V
A
I
K
R
I
-
R
L
E
H
-------
T
---
A
I
R
E
V
S
L
L
K
E
L
Q
-
H
R
N
I
I
E
L
K
S
V
I
H
------
H
N
H
R
L
H
L
I
F
E
Y
A
E
-
N
D
L
K
K
Y
M
D
K
N
P
--------------
D
V
S
M
R
V
I
K
S
F
L
Y
Q
L
I
N
G
V
N
F
C
H
S
R
R
C
L
H
R
D
L
K
P
Q
N
L
L
L
S
V
---
E
T
P
V
L
K
I
G
D
F
G
L
A
R
A
F
--------------
E
---
I
I
--
T
L
W
Y
R
P
P
E
I
L
L
G
S
R
----
H
Y
S
T
S
V
D
I
W
S
I
A
C
I
W
A
E
M
L
M
K
T
P
L
F
P
G
D
S
E
I
D
Q
L
F
K
I
F
E
V
L
G
L
P
D
D
T
T
W
P
G
V
T
A
-
L
P
D
-
W
K
Q
S
F
P
K
F
R
G
K
T
L
K
R
V
L
G
A
L
L
D
D
--
E
G
L
D
L
L
T
A
M
L
E
M
D
P
V
K
R
I
---
S
A
K
N
A
L
E
H
P
Y
F
S
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
73.17
41%
-31
- C1 -
-
4EOI
2
CDK2_HUMAN
A:
[2-288]
------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
-
R
L
-------
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
-
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
N
K
L
Y
L
V
F
E
F
L
H
-
Q
D
L
K
D
F
M
D
A
S
A
L
T
G
------------
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
--------
P
V
R
T
Y
THE
V
V
--
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
----
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
-
D
Y
K
P
S
F
P
K
W
A
R
Q
D
F
S
K
V
V
P
---
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
---
S
A
K
A
A
L
A
H
P
F
F
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
72.87
41%
-34
- C1 -
-
4EOM
1
CDK2_HUMAN
A:
[5-291]
------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
-
R
L
----
E
-
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
-
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
N
K
L
Y
L
V
F
E
F
L
S
-
M
D
L
K
K
F
M
D
A
S
A
L
T
G
------------
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
--------
P
V
R
T
Y
THE
V
V
--
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
----
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
-
D
Y
K
P
S
F
P
K
W
A
R
Q
D
F
S
K
V
V
P
---
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
---
S
A
K
A
A
L
A
H
P
F
F
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
72.55
41%
-31
- C1 -
-
4EOP
1
CDK2_HUMAN
A:
[4-290]
------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
-
R
L
D
-----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
-
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
N
K
L
Y
L
V
F
E
F
L
H
-
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
------------
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
--------
P
V
R
T
Y
THE
V
V
--
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
----
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
-
D
Y
K
P
S
F
P
K
W
A
R
Q
D
F
S
K
V
V
P
---
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
---
S
A
K
A
A
L
A
H
P
F
F
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
71.10
41%
-30
- C1 -
-
2IW8
1
CDK2_HUMAN
A:
[5-291]
------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
-
R
L
D
--
T
E
-
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
-
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
N
K
L
Y
L
V
F
E
H
V
D
-
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
------------
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
--------
P
V
R
T
Y
THE
V
V
--
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
----
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
-
D
Y
K
P
S
F
P
K
W
A
R
Q
D
F
S
K
V
V
P
---
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
---
S
A
K
A
A
L
A
H
P
F
F
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
70.68
40%
-31
- C1 -
-
1FVV
1
CDK2_HUMAN
A:
[1-287]
------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
-
R
L
D
--
T
E
-
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
-
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
N
K
L
Y
L
V
F
E
F
L
H
-
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
------------
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-----
T
Y
T
H
E
---
V
V
--
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
----
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
-
D
Y
K
P
S
F
P
K
W
A
R
Q
D
F
S
K
V
V
P
---
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
---
S
A
K
A
A
L
A
H
P
F
F
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
69.86
40%
-41
- C1 -
-
1DI8
1
CDK2_HUMAN
A:
[1-287]
------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
-
R
---------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
-
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
N
K
L
Y
L
V
F
E
F
L
H
-
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
------------
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
--------------
E
---
V
V
--
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
----
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
-
D
Y
K
P
S
F
P
K
W
A
R
Q
D
F
S
K
V
V
P
---
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
---
S
A
K
A
A
L
A
H
P
F
F
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
Fugue
69.07
28%
5
- C1 -
-
4AW2
5
MRCKA_RAT
A:
[1-416]
S
G
E
V
R
L
R
Q
L
E
Q
F
I
L
D
GPAQTNGQCFS
V
E
T
L
L
D
I
L
I
C
L
Y
D
E
C
N
N
SPLRRE
K
N
I
L
E
Y
L
E
W
A
K
P
F
T
S
K
V
K
Q
M
RLH
R
E
D
F
E
I
L
K
V
I
G
R
G
A
F
G
E
V
A
V
V
K
L
K
N
A
D
K
V
F
A
M
K
I
L
N
K
W
E
M
L
K
R
-
A
E
T
A
---
C
F
R
E
E
R
D
V
L
V
N
G
D
S
K
W
I
T
T
L
H
Y
A
F
Q
------
D
D
N
N
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F
E
D
R
-------------
L
P
E
E
M
A
R
F
Y
L
A
E
M
V
I
A
I
D
S
V
H
Q
L
H
Y
V
H
R
D
I
K
P
D
N
I
L
M
D
M
N
G
H
----
I
R
L
A
D
F
G
S
C
L
K
L
M
E
-
D
G
-----
T
V
Q
S
S
---
V
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
A
M
E
GGKG
R
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
E
T
P
F
Y
A
E
S
L
V
E
T
Y
G
K
I
M
N
------------------
H
K
E
R
F
Q
F
P
T
Q
---------
V
T
D
V
S
E
--
N
A
K
D
L
I
R
R
-
L
I
C
S
R
E
H
R
L
GQN
G
I
E
D
F
K
K
H
P
F
F
S
-
G
I
D
W
D
N
I
R
N
C
E
A
--------
P
Y
I
P
E
V
S
S
P
T
D
T
S
N
F
D
V
D
S
G
H
H
L
P
F
V
G
F
T
Y
T
S
S
C
V
L
S
D
R
S
C
L
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
69.06
40%
-30
- C1 -
-
1FIN
1
CDK2_HUMAN
A:
[1-287]
------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
-
R
L
D
--
T
E
-
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
-
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
N
K
L
Y
L
V
F
E
F
L
H
-
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
------------
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-----
T
Y
T
H
E
---
V
V
--
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
----
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
-
D
Y
K
P
S
F
P
K
W
A
R
Q
D
F
S
K
V
V
P
---
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
---
S
A
K
A
A
L
A
H
P
F
F
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
68.79
40%
-35
- C1 -
-
1JSV
1
CDK2_HUMAN
A:
[1-287]
------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
-------------T--
A
I
R
E
I
S
L
L
K
E
L
N
-
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
N
K
L
Y
L
V
F
E
F
L
H
-
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
------------
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-----
T
Y
T
H
E
---
V
V
--
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
----
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
-
D
Y
K
P
S
F
P
K
W
A
R
Q
D
F
S
K
V
V
P
---
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
---
S
A
K
A
A
L
A
H
P
F
F
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
68.27
40%
-42
- C1 -
-
1FVT
1
CDK2_HUMAN
A:
[1-287]
------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
-
R
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
-
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
N
K
L
Y
L
V
F
E
F
L
H
-
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
------------
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
-----------------
V
V
--
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
----
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
-
D
Y
K
P
S
F
P
K
W
A
R
Q
D
F
S
K
V
V
P
---
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
---
S
A
K
A
A
L
A
H
P
F
F
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
67.86
40%
-41
- C1 -
-
1KE6
1
CDK2_HUMAN
A:
[1-287]
------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
-
R
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
-
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
N
K
L
Y
L
V
F
E
F
L
H
-
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
------------
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
-------------------
V
--
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
----
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
-
D
Y
K
P
S
F
P
K
W
A
R
Q
D
F
S
K
V
V
P
---
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
---
S
A
K
A
A
L
A
H
P
F
F
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
67.40
39%
-95
- C1 -
-
1UA2
1
CDK7_HUMAN
D:
[13-297]
----------------------------------------------------------------------------
E
K
L
D
F
L
G
E
G
Q
F
A
T
V
Y
K
A
R
D
K
N
T
N
Q
I
V
A
I
K
K
I
----------
N
R
T
---
A
L
R
E
I
K
L
L
Q
E
L
S
-
H
P
N
I
I
G
L
L
D
A
F
G
------
H
K
S
N
I
S
L
V
F
D
F
M
E
-
T
D
L
E
V
I
I
K
D
N
S
-------------
L
V
L
T
P
S
H
I
K
A
Y
M
L
M
T
L
Q
G
L
E
Y
L
H
Q
H
W
I
L
H
R
D
L
K
P
N
N
L
L
L
D
E
----
N
G
V
L
K
L
A
D
F
G
L
A
K
S
F
G
S
-
P
N
R----
A
Y
T
H
Q
---
V
V
--
T
R
W
Y
R
A
P
E
L
L
F
G
A
R
----
M
Y
G
V
G
V
D
M
W
A
V
G
C
I
L
A
E
L
L
L
R
V
P
F
L
P
G
D
S
D
L
D
Q
L
T
R
I
F
E
T
L
G
T
P
T
E
E
Q
W
P
D
M
C
S
-
L
P
D
Y
V
T
F
K
--
S
F
P
G
I
P
L
-
H
H
I
F
S
A
A
G
D
--
D
L
L
D
L
I
Q
G
L
F
L
F
N
P
C
A
R
I
---
T
A
T
Q
A
L
K
M
K
Y
F
S
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
67.00
40%
-40
- C1 -
-
3EZV
1
CDK2_HUMAN
A:
[3-289]
------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
-
R
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
-
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
N
K
L
Y
L
V
F
E
F
L
H
-
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
------------
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
----------------------
V
V
--
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
----
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
-
D
Y
K
P
S
F
P
K
W
A
R
Q
D
F
S
K
V
V
P
---
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
---
S
A
K
A
A
L
A
H
P
F
F
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
66.50
40%
-39
- C1 -
-
5K4J
1
CDK2_HUMAN
A:
[2-288]
------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
-
R
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
-
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
N
K
L
Y
L
V
F
E
F
L
H
-
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
------------
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
---------------
E
---
V
V
--
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
----
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
-
D
Y
K
P
S
F
P
K
W
A
R
Q
D
F
S
K
V
V
P
---
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
---
S
A
K
A
A
L
A
H
P
F
F
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
66.38
40%
-34
- C1 -
-
1F5Q
-
CDK2_HUMAN
A:
[1-287]
------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
--
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
-
R
L
D
--
T
E
-
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
-
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
N
K
L
Y
L
V
F
E
F
L
H
-
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
------------
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-----
T
Y
T
H
E
---
V
V
--
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
----
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
-
D
Y
K
P
S
F
P
K
W
A
R
Q
D
F
S
K
V
V
P
---
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
---
S
A
K
A
A
L
A
H
P
F
F
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
66.12
40%
-38
- C- -
-
1JVP
1
CDK2_HUMAN
P:
[1-287]
------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
-
R
----------
V
PST
A
I
R
E
I
S
L
L
K
E
L
N
-
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
N
K
L
Y
L
V
F
E
F
L
H
-
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
------------
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
------------------
V
V
--
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
----
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
-
D
Y
K
P
S
F
P
K
W
A
R
Q
D
F
S
K
V
V
P
---
P
L
DE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
---
S
A
K
A
A
L
A
H
P
F
F
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
66.04
40%
-39
- C1 -
-
1KE5
1
CDK2_HUMAN
A:
[1-287]
------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
-
R
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
-
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
N
K
L
Y
L
V
F
E
F
L
H
-
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
------------
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
------------------
V
V
--
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
----
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
-
D
Y
K
P
S
F
P
K
W
A
R
Q
D
F
S
K
V
V
P
---
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
---
S
A
K
A
A
L
A
H
P
F
F
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
65.91
40%
-38
- C1 -
-
1KE7
1
CDK2_HUMAN
A:
[1-287]
------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
-
R
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
-
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
N
K
L
Y
L
V
F
E
F
L
H
-
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
------------
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
------------------
V
V
--
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
----
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
-
D
Y
K
P
S
F
P
K
W
A
R
Q
D
F
S
K
V
V
P
---
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
---
S
A
K
A
A
L
A
H
P
F
F
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
65.04
40%
-35
- C1 -
-
1CKP
2
CDK2_HUMAN
A:
[1-287]
------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
------------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
-
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
N
K
L
Y
L
V
F
E
F
L
H
-
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
------------
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
-------------------
V
--
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
----
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
-
D
Y
K
P
S
F
P
K
W
A
R
Q
D
F
S
K
V
V
P
---
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
---
S
A
K
A
A
L
A
H
P
F
F
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
64.19
40%
-31
- C1 -
-
1GIH
1
CDK2_HUMAN
A:
[1-287]
------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
-
R
-----------P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
-
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
N
K
L
Y
L
V
F
E
F
L
H
-
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
------------
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
----------------------
V
--
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
----
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
-
D
Y
K
P
S
F
P
K
W
A
R
Q
D
F
S
K
V
V
P
---
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
---
S
A
K
A
A
L
A
H
P
F
F
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
64.13
40%
-41
- C1 -
-
3EZR
2
CDK2_HUMAN
A:
[3-289]
------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
-
R
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
-
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
N
K
L
Y
L
V
F
E
F
L
H
-
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
------------
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
----------------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
----
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
-
D
Y
K
P
S
F
P
K
W
A
R
Q
D
F
S
K
V
V
P
---
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
---
S
A
K
A
A
L
A
H
P
F
F
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
62.33
36%
-29
- C1 -
-
5BYZ
7
MK07_HUMAN
A:
[6-304]
-------------------------------------------------------------------------
D
E
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
R
L
T
G
Q
Q
V
A
I
K
K
I
-
P
N
A
F
D
V
V
T
N
A
K
R
---
T
L
R
E
L
K
I
L
K
H
F
-
K
H
D
N
I
I
A
I
K
D
I
L
R
P
TVPYG
E
F
K
S
V
Y
V
V
L
D
L
M
E
-
S
D
L
H
Q
I
I
H
S
S
Q
--------------
P
L
T
L
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
E
----
N
C
E
L
K
I
G
D
F
G
M
A
R
G
L
C
T
-
S
P
AEHQY
F
M
T
E
Y
---
V
A
--
T
R
W
Y
R
A
P
E
L
M
L
S
L
H
----
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
R
R
Q
L
F
P
G
K
N
Y
V
H
Q
L
Q
L
I
M
M
V
L
G
T
P
S
P
A
V
I
Q
A
V
G
A
E
R
V
R
A
Y
I
Q
S
L
P
P
R
Q
-
P
V
P
W
E
T
V
Y
P
G
A
D
R
--
Q
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
---
S
A
A
A
A
L
R
H
P
F
L
A
K
Y
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
60.67
40%
-4
- C1 -
-
1G5S
1
CDK2_HUMAN
A:
[1-287]
------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
-
R
-----------S
T
-
A
I
R
E
I
S
L
L
K
E
L
N
-
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
N
K
L
Y
L
V
F
E
F
L
H
-
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
------------
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
----
I
K
L
A
D
F
G
L
----------------------
V
V
--
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
----
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
-
M
P
-
D
Y
K
P
S
F
P
K
W
A
R
Q
D
F
S
K
V
V
P
---
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
---
S
A
K
A
A
L
A
H
P
F
F
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------