@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_28_0620: (2018-03-11 )
MDNYDVLEVIGEGTYGVVFKCCDKRTNRIVAVKQFKNFQANAYVRVAMLRELRVEQLLKGEPNVTQLLETFKQKNRLYLVMEYIPRSLLDVLEEVQHGLPEDSLVVLLFTILLGIRSCHRNGIIHRDVKPENILVRDDGTASLCDFGFCRPLPRQLQPQAQQLSISSQDIGPSASPIAESGSFGLRSLPPPNDTPQMCNGASVSSANSAMLSELVLADHQAIMTNYVATRWYRSPEMLLGMPSYTYAVDMWAVGAIMAEAIDGEPLLPGKTELEQLSLIQTRIGDFPAAYEAAVRKRNGGTLRLHSLNPLAAPPQQLRTKSMQQKSRRASDARDAAQKRTESKQGTRSYLTERYGGRIAKAGLNLLHRLLRIDAAERITVEEALGHPYFDSVRGRFDAAPNGARGARNSNGACDEAAEMQPTTAETAGPTPMPLTTTASRQAPLPPLTATGAADCISPLLSMSDAAGGGGSTCLAAAAPPLVEVPFSLVDRVGAGADDDGGGPLQMPCCAERSPRVTTVAWEALSSSPGSRAPCAVASGNSSTTNSSSLSLWTASDTSAEVAPPTDVTVAKDHVSFPRFSSVLVPLHPELPKPTETGCRHASAAACNGAAEGGNSPPPLAPEESNNGGQPVLRRQAASEGANTRATQRDASMHSDDCSSTSLLQSRQSHHSPRDARQLRHRKSSLESGGNVAALRGSDSSPMNTAAQEPSGAGGAVPTTAVSGMDDPASPSVLQSRRTAQRRSGGVVDSRLSSSKISAANACRTTSPSSLPAKTYSFKSIPTSRSKALAPNVVQSTSKYDLMQSAPEDHTEKRRHPSGPVSAPRCQGSGRGVEKGAAANSKGAHTCSSSSSMMSNALRSARGDPGRTGGLGSATKERRSSVGRRIDGHGLHVVPAAPSCVNATTPASSCRATAQEPAEVSLLRRRSTAKSRPPPQPGRRTSTPTARGGIANGNHHSPTLPRPLFARSSPEAPALLSVSDARVGGGKKRGLSRFVSPHLPREVRPLPAPERFTLLQEIESLEFVVGPPSAVEVLAPVVAALVSHTPEHAESDTDAGGGTRDRNEGDTRASTIACAEHVVPASQPPEMLDNDVQPNGDRGGGNSSSSLTLGETRRRCSGTASSRAWAAKRDTAASGKTSALVEATANSKLEDNGRQQSLQRPPHPCGGTGGRPLRMDSNSHSGNTSTHNANATTVGSSRAAPSLIFRSSRTASSPLKLATIHPFSFALQGEGELRELSTNGCHASTSASTGMSFTTPNSVASPPTRRLAPALLRHHHPATAVGACLVQASTSLGPDPVFGSSAFSAHSPLVAKDSAWSPTLSPKPQKRSETDARRASMESPIVSLSGTRQQRCLSDIPIELSLSEELFADSAACGPRVRHRRHENATPLSTTPPLTMPDDLETVVLMGTPPAPRRTNQQRQDEVPCTATWSPTRSGATAMMSTSMPGNSAPFRGLDRDSDGSSAPFEGKGSAAKTEAVDITARTRRHSVAPALFAAAPKGVPALNEDDLTNVCETSSLPMRGSLEARGAGNGASTSSRKIPGPALAPPQPLLGGASVLSAQQLHAGGGRRKSRLVL
Atome Classification :
(20 SA)
.........10........20........30........40........50........-----60....----.----.-----..70.------.--------.--.....80.....-...90.....--.--..100.......110.......120.......130...--.-.---..140.........150.......160.......170.......180...-....190.......---200.......210.......220.......230.......240.......250.......260..-----------.....270.-.......280......-.290.......300...---....310.---...-...320..--.....330.......340...-....350.......360.......370.......380.......--390.......400.......410.......420.......430.......440.-......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320......1330......1340......1350......1360......1370......1380......1390......1400......1410......1420......1430......1440......1450......1460......1470......1480......1490......1500......1510......1520......1530......1540......1550......1560......1570.
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MDN
Y
D
V
L
E
V
IGEGTY
G
V
V
F
K
C
CDKRT
N
R
I
V
A
V
K
Q
FKNFQA
N
A
Y
V
R
V
A
M
L
R
E
L
R
V
E
Q
L
LK-----GEP
N
V
T
----
Q
----
L
-----
L
E
T
F
K
------Q--------K--N
R
L
Y
L
V
M
E
Y
I
P
R
-
S
L
L
D
V
L
E
E
V
Q
--H--GLPE
D
S
L
V
V
L
L
F
T
I
L
L
G
I
R
S
C
H
RNG
I
I
HRDVKPE
N
I
L
V
--R-D---DGT--
A
S
L
CDFGFCRPL
P
R
QLQP
Q
A
Q
QLSISSQDIGPSASPIAESGSFGL-RSLPPPNDTPQMCN---GASVS
S
A
N
S
A
M
L
S
E
L
V
L
A
D
H
Q
A
I
M
T
N
Y
V
A
T
R
WYR
S
P
E
M
L
LGMPS
Y
T
Y
A
V
D
M
W
A
V
G
A
I
M
A
E
AIDGE-----------PLLPG
K
T
-
E
-
L
E
Q
L
S
L
I
Q
T
R
IGDF
P
A
-
A
Y
E
A
A
V
RKRNG
G
T
L
R
L
H---SLNPLAA
P
---
P
Q
Q
-
L
R
T
K
S
M
Q
Q
--
K
S
RRAS
D
A
R
D
A
A
Q
K
RTESKQ
G
-
T
R
S
Y
L
T
E
R
YGG
R
I
A
K
A
G
L
N
L
L
H
R
L
L
RIDAAE
R
I
T
V
E
E
ALGHP
Y
F
--
D
S
V
RGRFDAAPNGARGARNSNGACDEAAEMQPTTAETAGPTPM
P
L
TTTASRQAP-LPPLTATG
A
A
D
C
I
S
P
L
L
S
MSDAAGGGGS
T
C
LAAAAPPLVEV
P
F
S
L
V
D
R
VGAGADDDGGGPLQMPCCAERSP
R
V
T
T
V
A
W
E
A
LSSSPGSRA
P
C
A
V
ASGNSSTTNS
S
S
L
S
L
W
TASDTSAEVAPPT
D
V
T
V
AKDHVSFP
R
F
S
S
V
L
VPLHPELPKPTETGCRHASAAACNGAAEGGNSPPPLAPEESNNGGQ
P
V
L
R
R
Q
AASEGANTRATQRDASMHSDDCS
S
T
S
L
L
Q
S
R
Q
SHHSP
R
D
A
R
Q
L
R
H
R
K
S
S
LESGG
N
V
A
A
L
RGSDSSPMNTAAQEPSGAGGAVPTTAVSGMDDPAS
P
S
V
L
Q
S
R
R
T
A
Q
RRSGGVVDSRLSSSKISAANACRTTSPSSLPAKT
Y
S
FKSIPTSRSKALA
P
N
V
V
QSTSK
Y
D
L
M
Q
SAPED
H
T
E
KRRHPSGPVSAPRCQGSGRGVEKGAAANSKGAHTCS
S
S
S
S
M
M
S
N
A
L
R
SARGDPGRTGGLG
S
A
T
K
E
R
R
S
S
VGRRIDGH
G
L
H
VVPAAPSCVNATT
P
A
S
S
C
R
ATAQE
P
A
E
V
S
L
L
R
RRSTAKSRPPPQPGRRTSTPTARGGIANGNHHSPTLPRPLFARSSPEA
P
A
L
L
S
VSDARVGGGKKR
G
L
S
R
FVSPHLPREVRPLP
A
P
E
R
F
T
L
L
Q
E
I
E
SL
E
F
VVGP
P
S
A
V
E
V
L
A
P
V
V
A
A
L
V
SHTPEHAESDTDAGGGTRDRNEGDTR
A
S
T
I
A
C
A
E
HVVPASQ
P
P
E
M
LDNDVQPNGDRGGGNSSS
S
L
T
L
G
E
T
R
R
RCSGTASSRAWAAKRDTAASGK
T
S
A
L
V
E
ATANSKLEDNGRQQSLQRPPHPCGGTGGR
P
L
R
MDSNSHSGNTSTHNAN
A
T
TVGSSRAA
P
S
L
I
F
RSSRTASSP
L
K
L
A
T
IH
P
F
S
F
A
LQGEG
E
L
R
E
LSTNGCHASTSASTG
M
S
FTTPNSVASP
P
T
R
R
L
A
P
A
L
L
RHHH
P
A
T
A
V
G
A
C
L
V
Q
ASTSLGPDPVFGSSAFSAHSPLVAKDSAWSPTLSPKPQKRS
E
T
D
A
R
RASMES
P
I
V
SLSG
T
R
Q
Q
R
C
L
SDI
P
I
E
L
SL
S
E
E
L
FADSAACGP
R
V
R
H
RRHENATPLSTTPPLTMPDDL
E
T
V
V
L
MGTPPAPRRTN
Q
Q
R
QDEVPCTATWSPTRSG
A
T
A
M
M
STSMPGNSAPFRGLDRDSDGSSAPFEGKGSAAK
T
E
A
V
D
I
T
A
RTRRHSV
A
P
A
L
F
AAAPKGVPAL
N
E
D
D
L
T
N
V
CETSSLPMRGSLEARGAGNGASTSSRKIPGPALAPPQPLLGG
A
S
V
L
S
A
Q
Q
L
HAGGGR
R
K
S
RLVL
28
HHSearch
90.02
40%
-134
- C1 -
-
4BGQ
3
CDKL5_HUMAN
A:
[12-301]
-
N
K
F
E
I
L
G
V
V
G
E
G
A
Y
G
V
V
L
K
C
R
H
K
E
T
H
E
I
V
A
I
K
K
F
K
-------
V
K
E
T
T
L
R
E
L
K
M
L
R
T
L
K
------
Q
E
N
I
V
----
E
----
L
-----
K
E
A
F
R
------
R
--------
R
--
G
K
L
Y
L
V
F
E
Y
V
E
K
-
N
M
L
E
L
L
E
E
M
P
--
N
--
G
V
P
P
E
K
V
K
S
Y
I
Y
Q
L
I
K
A
I
H
W
C
H
K
N
D
I
V
H
R
D
I
K
P
E
N
L
L
I
--
S
-
H
---
N
D
V
--
L
K
L
C
D
F
G
F
A
R
N
L
S
E
------------------------------------------------------------------------------
T
R
W
Y
R
S
P
E
L
L
L
G
A
-
P
Y
G
K
S
V
D
M
W
S
V
G
C
I
L
G
E
L
S
D
G
Q
-----------
P
L
F
P
G
E
S
-
E
-
I
D
Q
L
F
T
I
Q
K
V
L
G
P
L
P
S
-
E
Q
M
K
L
F
Y
S
--
N
P
------------
R
-----------
F
-----
H
--
G
L
R
F
-----
P
----
A
V
----
N
-
H
P
Q
S
L
E
R
R
Y
L
G
I
L
N
S
V
L
L
D
L
M
K
N
L
L
K
L
D
P
A
D
R
Y
L
T
E
Q
C
L
N
H
P
T
F
--
Q
T
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
79.83
30%
-126
- C1 -
-
4AGU
1
CDKL1_HUMAN
A:
[3-292]
-
E
K
Y
E
K
I
G
K
I
G
E
G
S
Y
G
V
V
F
K
C
R
N
R
D
T
G
Q
I
V
A
I
K
K
F
L
E
S
E
D
-
P
V
I
K
K
I
A
L
R
E
I
R
M
L
K
Q
L
K
------
H
P
N
L
V
----
N
----
L
-----
L
E
V
F
R
------
R
--------
K
--
R
R
L
H
L
V
F
E
Y
C
D
H
-
T
V
L
H
E
L
D
R
Y
Q
--
R
--
G
V
P
E
H
L
V
K
S
I
T
W
Q
T
L
Q
A
V
N
F
C
H
K
H
N
C
I
H
R
D
V
K
P
E
N
I
L
I
--
T
-
K
---
H
S
V
--
I
K
L
C
D
F
G
F
A
R
L
L
-----------------
T
------------
R
W
Y
-
R
S
---------------------------
P
E
L
L
V
G
D
T
Q
-----------------------
Y
G
P
P
V
D
V
W
A
I
G
C
V
F
A
E
L
L
S
G
V
-----------
P
L
W
P
G
K
S
-
D
-
V
D
Q
L
Y
L
I
R
K
T
L
G
D
----------------------------
L
I
P
R
---
H
Q
Q
-
V
F
S
T
N
Q
Y
F
--
S
G
V
K
I
P
D
P
E
D
--
M
E
P
L
E
L
K
F
P
-
N
I
S
Y
-----------
P
A
L
G
L
L
K
G
C
L
H
M
D
P
T
E
R
L
T
C
E
Q
L
L
H
H
P
Y
F
--
E
N
I
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
78.47
32%
-118
- C1 -
-
1V0B
-
CDC2H_PLAFK
A:
[1-286]
M
E
K
Y
H
G
L
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
Q
N
N
-
Y
G
E
T
F
A
L
K
K
I
R
L
E
K
E
D
E
G
I
P
S
T
T
I
R
E
I
S
I
L
K
E
L
K
------
H
S
N
I
V
----
K
----
L
-----
Y
D
V
I
H
------
T
--------
K
--
K
R
L
V
L
V
F
E
H
L
D
Q
-
D
L
K
K
L
L
D
V
C
E
--
G
--
G
L
E
S
V
T
A
K
S
F
L
L
Q
L
L
N
G
I
A
Y
C
H
D
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
-
R
---
E
G
E
--
L
K
I
A
D
F
G
L
A
R
A
F
G
I
P
V
--------------------------------------------------------------------
R
K
Y
T
H
E
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
T
I
D
I
W
S
V
G
C
I
F
A
E
M
V
N
G
A
-----------
P
L
F
P
G
V
S
-
E
-
A
D
Q
L
M
R
I
F
R
I
L
G
T
P
N
S
-
K
N
W
P
N
V
T
E
L
----------------------
P
K
Y
-
D
--------------
P
N
F
-----------
T
V
-
Y
E
P
L
P
W
E
S
F
L
K
G
L
D
E
S
G
I
D
L
L
S
K
M
L
K
L
D
P
N
Q
R
I
T
A
K
Q
A
L
E
H
A
Y
F
--
K
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
74.30
29%
-109
- C1 -
-
3ZDU
3
CDKL3_HUMAN
A:
[2-287]
M
E
M
Y
E
T
L
G
K
V
G
E
G
S
Y
G
T
V
M
K
C
K
H
K
N
T
G
Q
I
V
A
I
K
I
F
Y
-------
N
K
I
A
M
-
R
E
I
K
F
L
K
Q
F
H
-----
H
E
-
N
L
V
----
N
----
L
-----
I
E
V
F
R
------
Q
--------
K
--
K
K
I
H
L
V
F
E
F
I
D
H
-
T
V
L
D
E
L
Q
H
Y
C
--
H
--
G
L
E
S
K
R
L
R
K
Y
L
F
Q
I
L
R
A
I
D
Y
L
H
S
N
N
I
I
H
R
D
I
K
P
E
N
I
L
V
--
S
-
Q
---
S
G
I
--
T
K
L
C
D
F
G
F
A
-------------------------------------
R
T
-----
D
-------------------------------
I
Y
D
D
E
V
A
T
R
W
Y
R
A
P
E
L
V
L
K
D
T
S
Y
G
K
P
V
D
I
W
A
L
G
C
M
I
I
E
M
A
T
G
N
-----------
P
Y
L
P
S
S
S
-
D
-
L
D
L
L
H
K
I
V
L
K
V
G
N
L
S
P
-
H
L
Q
-----------
N
I
F
---
S
K
S
P
I
F
A
G
VV
L
P
Q
V
-
Q
H
P
K
N
A
R
K
--
K
--------------------------
Y
P
K
L
N
G
L
L
A
----
D
I
V
H
A
C
L
Q
I
D
P
A
D
R
I
S
S
S
D
L
L
H
H
E
Y
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
73.67
32%
-34
- C1 -
-
5BYZ
7
MK07_HUMAN
A:
[6-305]
-
D
E
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
R
L
T
G
Q
Q
V
A
I
K
K
I
P
N
A
F
D
V
V
T
N
A
K
R
T
L
R
E
L
K
I
L
K
H
F
------
K
H
D
N
I
I
----
A
----
I
-----
K
D
I
L
R
P
TVPYG
E
--------
F
--
K
S
V
Y
V
V
L
D
L
M
E
S
-
D
L
H
Q
I
I
H
S
S
---
Q
--
P
L
T
L
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
--
N
-
E
---
N
C
E
--
L
K
I
G
D
F
G
M
A
R
G
L
C
T
S
P
A
E
----------------------------------------------------------------
H
Q
Y
F
M
T
E
Y
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
R
R
-----------
Q
L
F
P
G
K
N
-
Y
-
V
H
Q
L
Q
L
I
M
M
V
L
G
T
P
S
P
-
A
V
I
Q
A
V
G
---
A
E
R
V
R
-----
A
---------------
Y
I
Q
S
L
-----------------------
P
P
-
R
Q
P
V
P
W
E
T
V
Y
P
G
A
D
R
Q
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
--
A
K
Y
H
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
72.23
31%
-118
- C1 -
-
1UA2
1
CDK7_HUMAN
D:
[13-298]
----
E
K
L
D
F
L
G
E
G
Q
F
A
T
V
Y
K
A
R
D
K
N
T
N
Q
I
V
A
I
K
K
I
---------
N
R
T
A
L
R
E
I
K
L
L
Q
E
L
S
------
H
P
N
I
I
----
G
----
L
-----
L
D
A
F
G
------
H
--------
K
--
S
N
I
S
L
V
F
D
F
M
E
T
-
D
L
E
V
I
I
K
D
N
S
--
L
--
V
L
T
P
S
H
I
K
A
Y
M
L
M
T
L
Q
G
L
E
Y
L
H
Q
H
W
I
L
H
R
D
L
K
P
N
N
L
L
L
--
D
-
E
---
N
G
V
--
L
K
L
A
D
F
G
L
A
K
S
F
G
S
P
N
--------------------------------------------------------------------
R
A
Y
T
H
Q
V
V
T
R
W
Y
R
A
P
E
L
L
F
G
A
R
M
Y
G
V
G
V
D
M
W
A
V
G
C
I
L
A
E
L
L
L
R
V
-----------
P
F
L
P
G
D
S
-
D
-
L
D
Q
L
T
R
I
F
E
T
L
G
T
P
T
E
-
E
Q
W
P
D
M
C
S
---
L
-----------------------------
P
D
--
Y
V
--------------
T
F
K
-
S
-
F
P
G
I
P
L
H
H
I
F
S
A
A
G
D
D
L
L
D
L
I
Q
G
L
F
L
F
N
P
C
A
R
I
T
A
T
Q
A
L
K
M
K
Y
F
--
S
N
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
70.06
28%
-92
- C1 -
-
4AAA
7
CDKL2_HUMAN
A:
[24-319]
M
E
K
Y
E
N
L
G
L
V
G
E
G
S
Y
G
M
V
M
K
C
R
N
K
D
T
G
R
I
V
A
I
K
K
F
L
E
S
D
D
D
K
M
V
K
K
I
A
M
R
E
I
K
L
L
K
Q
L
R
-----
H
E
-
N
L
V
----
N
----
L
-----
L
E
V
C
K
------
K
--------
K
--
K
R
W
Y
L
V
F
E
F
V
D
H
-
T
I
L
D
D
L
E
L
F
P
--
N
--
G
L
D
Y
Q
V
V
Q
K
Y
L
F
Q
I
I
N
G
I
G
F
C
H
S
H
N
I
I
H
R
D
I
K
P
---------------------------------------------
E
N
I
L
V
S
Q
S
G
V
V
K
L
C
D
F
G
F
A-------------------------------------------
E
V
A
T
R
W
Y
R
A
P
E
L
L
V
G
D
V
K
Y
G
K
A
V
D
V
W
A
I
G
C
L
V
T
E
M
F
M
G
E
-----------
P
L
F
P
G
D
S
-
D
-
I
D
Q
L
Y
H
I
M
M
C
L
G
N
L
I
P
-
R
H
Q
E
L
F
N
K
--------------
N
P
V
F
A
------
G
-
V
R
L
P
E
I
K
E
-------------------------
R
E
P
L
E
R
R
Y
-
P
K
L
S
E
V
V
I
D
L
A
K
K
C
L
H
I
D
P
D
K
R
P
F
C
A
E
L
L
H
H
D
F
F
QM
D
G
F
A
E
R
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
69.46
31%
-61
- C1 -
-
4BGQ
3
CDKL5_HUMAN
A:
[11-302]
M
N
K
F
E
I
L
G
V
V
G
E
G
A
Y
G
V
V
L
K
C
R
H
K
E
T
H
E
I
V
A
I
K
K
F
K
-------
V
K
E
T
T
L
R
E
L
K
M
L
R
T
L
K
-----
Q
E
-
N
I
V
----
E
----
L
-----
K
E
A
F
R
------
R
--------
R
--
G
K
L
Y
L
V
F
E
Y
V
E
K
-
N
M
L
E
L
L
E
E
M
P
--
N
--
G
V
P
P
E
K
V
K
S
Y
I
Y
Q
L
I
K
A
I
H
W
C
H
K
N
D
I
V
H
R
D
I
K
P
--------------------------------------
E
N
L
L
I
S
H
-------------------------
N
D
V
L
K
L
C
D
FGF
A
R
N
L
S
E
-----------------------
T
R
W
Y
R
S
P
E
L
L
L
G
A
P
-
Y
G
K
S
V
D
M
W
S
V
G
C
I
L
G
E
L
S
D
G
Q
-----------
P
L
F
P
G
E
S
-
E
-
I
D
Q
L
F
T
I
Q
K
V
L
G
P
L
P
S
-
E
-----------
Q
M
K
L
F
---
Y
S
N
P
------------------------
R
F
H
G
L
R
F
P
A
V
N
H
P
Q
S
--------
L
E
R
R
Y
L
G
I
L
N
S
V
L
L
D
L
M
K
N
L
L
K
L
D
P
A
D
R
Y
L
T
E
Q
C
L
N
H
P
T
F
--
Q
T
Q
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
69.15
31%
-60
- C1 -
-
1UNL
1
CDK5_HUMAN
A:
[1-289]
M
Q
K
Y
E
K
L
E
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
R
E
T
H
E
I
V
A
L
K
R
V
R
L
D
D
D
D
E
G
V
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
------
H
K
N
I
V
----
R
----
L
-----
H
D
V
L
H
------
S
--------
D
--
K
K
L
T
L
V
F
E
F
C
D
Q
-
D
L
K
K
Y
F
D
S
C
N
--
G
--
D
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
-
R
---
N
G
E
--
L
K
L
A
N
F
G
L
A
R
A
F
G
I
P
V
--------------------------------------------------------------------
R
C
Y
S
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
-----------
R
P
L
F
P
G
N
-
D
V
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
-----------------
T
K
L
------
P
D
---
Y
K
-------
P
--
Y
------------
P
-
M
Y
P
-
A
T
T
S
L
-
V
N
V
V
P
K
L
N
A
T
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
--
S
D
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
68.91
28%
-89
- C1 -
-
4BBM
3
CDKL2_HUMAN
A:
[24-319]
M
E
K
Y
E
N
L
G
L
V
G
--
S
Y
G
M
V
M
K
C
R
N
K
D
T
G
R
I
V
A
I
K
K
F
L
E
S
D
D
D
K
M
V
K
K
I
A
M
R
E
I
K
L
L
K
Q
L
R
-----
H
E
-
N
L
V
----
N
----
L
-----
L
E
V
C
K
------
K
--------
K
--
K
R
W
Y
L
V
F
E
F
V
D
H
-
T
I
L
D
D
L
E
L
F
P
--
N
--
G
L
D
Y
Q
V
V
Q
K
Y
L
F
Q
I
I
N
G
I
G
F
C
H
S
H
N
I
I
H
R
D
I
K
P
---------------------------------------------
E
N
I
L
V
S
Q
S
G
V
V
K
L
C
D
F
G
F
A
R
T
L
A
A
P
G
E
-------------------------------
V
Y
D
D
E
V
A
T
R
W
Y
R
A
P
E
L
L
V
G
D
V
K
Y
G
K
A
V
D
V
W
A
I
G
C
L
V
T
E
M
F
M
G
E
-----------
P
L
F
P
G
D
S
-
D
-
I
D
Q
L
Y
H
I
M
M
C
L
G
N
L
I
P
-
R
H
Q
E
L
F
N
K
--------------
N
P
V
F
A
------
G
-
V
R
L
P
E
I
K
E
-------------------------
R
E
P
L
E
R
R
Y
-
P
K
L
S
E
V
V
I
D
L
A
K
K
C
L
H
I
D
P
D
K
R
P
F
C
A
E
L
L
H
H
D
F
F
QM
D
G
F
A
E
R
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
Fugue
68.68
16%
-
- C1 -
-
3QA8
-
?
A:
[16-666]
----
E
M
K
E
R
L
G
T
G
G
F
G
Y
V
L
R
W
I
H
Q
D
T
G
E
Q
V
A
I
K
Q
C
R
Q
-
E
L
S
P
K
N
R
E
R
W
C
L
E
I
Q
I
M
K
K
L
N
-----
H
P
N
V
V
S
----
A
----
R
EVPDG
L
Q
K
L
A
------
P
--------
N
--
D
L
P
L
L
A
M
E
Y
C
E
G
G
D
L
R
K
Y
L
N
Q
F
E
--
N
CC
G
L
K
E
G
P
I
R
T
L
L
S
D
I
S
S
A
L
R
Y
L
H
E
N
R
I
I
H
R
D
L
K
P
E
N
I
V
L
--
Q
-
P
GPQ
R
L
I
--
H
K
I
I
D
L
G
Y
A
K
E
L
---------------------------------------------------------------------
D
Q
G
E
L
C
T
E
F
V
G
T
L
Q
Y
L
A
P
E
-
L
L
E
Q
K
K
Y
T
V
T
V
D
Y
W
S
F
G
T
L
A
F
E
C
I
T
G
F
R----------
P
F
L
P
N
W
Q
-
P
-
V
Q
W
H
G
K
V
R
I
------------
V
V
Y
D
D
L
T
G
A
V
K
F
S
---
S
V
L
P
T
P
N
H
---
L
S
G
-
I
L
A
G
K
L
E
R
--
W
L
Q
C
M
L
M
-
W
H
Q
R
T
D
P
Q
N
P
N
V
G
-
C
F
Q
A
L
D
S
I
L
S
L
K
L
L
S
V
M
N
M
V
S
G
R
V
H
T
Y
P
V
T
E
N
E
N
L
Q
N
L
K
S
W
L
Q
Q
--
D
T
-----
G
I
P
E
E
E
Q
E
L
L
Q
A
S
G
L
A
L
N
S
A
Q
P
L
T
Q
Y
V
I
D
C
T
V
G
D
L
I
F
L
F
D
N
R
K
I
S
L
P
A
H
P
E
S
V
S
I
V
L
Q
D
P
K
R
P
L
T
Y
T
H
L
R
R
V
W
G
Q
I
W
Q
T
I
R
A
L
K
E
D
C
A
R
L
L
Q
G
Q
R
T
S
M
V
N
L
L
R
Y
N
T
E
L
S
K
K
K
N
S
M
T
S
E
C
E
Q
L
K
A
K
L
D
F
F
R
S
S
I
Q
I
D
L
E
K
Y
S
E
Q
M
E
F
G
I
T
S
E
K
L
L
S
A
W
R
E
M
E
Q
A
V
E
L
C
G
R
E
R
E
V
Q
A
L
V
D
K
M
M
A
L
Q
T
D
S
V
D
L
Q
R
N
P
T
L
D
D
L
E
E
Q
A
R
D
L
Y
R
R
L
R
E
R
P
R
D
Q
R
T
P
G
D
S
N
D
M
V
R
L
L
I
L
A
I
Q
S
F
E
K
R
V
I
L
I
Y
D
Q
L
S
K
T
V
V
C
K
R
K
A
L
E
L
S
P
K
V
K
E
V
M
N
L
M
R
E
D
E
K
I
V
V
R
R
Q
E
K
R
Q
Q
E
L
W
N
L
L
K
I
A
C
S
K
V
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
68.02
31%
-78
- C- -
-
3GBZ
-
?
A:
[13-305]
-
D
R
Y
R
R
I
T
K
L
G
E
G
T
Y
G
E
V
Y
K
A
I
D
T
V
T
N
E
T
V
A
I
K
R
I
R
L
E
H
--------
A
I
R
E
V
S
L
L
K
E
L
Q
------
H
R
N
I
I
----
E
----
L
-----
K
S
V
I
H
------
H
--------
N
--
H
R
L
H
L
I
F
E
Y
A
E
N
-
D
L
K
K
Y
M
D
K
N
---
P
--
D
V
S
M
R
V
I
K
S
F
L
Y
Q
L
I
N
G
V
N
F
C
H
S
R
R
C
L
H
R
D
L
K
P
Q
N
L
L
L
--
S
V----
T
P
V
--
L
K
I
G
D
F
G
L
A
R
A
F
G
-------------------------------------------------------------------------------
T
L
W
Y
R
P
P
E
I
L
L
G
S
R
H
Y
S
T
S
V
D
I
W
S
I
A
C
I
W
A
E
M
L
M
K
T
-----------
P
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
K
I
F
E
V
L
G
L
P
D
D
-
T
T
W
P
-------
G
V
T
A
---------
L
--
P
----
D
-------
W
------------
K
Q
S
F
P
K
------
F
-
R
G
K
T
L
K
R
V
L
G
A
L
L
D
D
E
G
L
D
L
L
T
A
M
L
E
M
D
P
V
K
R
I
S
A
K
N
A
L
E
H
P
Y
F
--
S
H
N
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
67.62
34%
-9
* C1 *
-
5LQF
1
CDK1_HUMAN
D:
[6-294]
M
E
D
Y
T
K
I
E
K
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
K
T
T
G
Q
V
V
A
M
K
K
I
R
L
E
S
E
E
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
R
------
H
P
N
I
V
----
S
----
L
-----
Q
D
V
L
M
------
Q
--------
D
--
S
R
L
Y
L
I
F
E
F
L
S
M
-
D
L
K
K
Y
L
D
S
I
P
PG
Q
--
Y
M
D
S
S
L
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
D
-
D
---
K
G
T
--
I
K
L
A
D
F
G
L
A
R
A
F
G
I
P
I
--------------------------------------------------------------------
R
-------
T
L
W
Y
R
S
P
E
V
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
T
K
K
-----------
P
L
F
H
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
A
L
G
T
P
N
N
-
E
V
W
P
E
V
E
S
----------------------------
L
Q
D
-
Y
------------
K
N
T
------
F
P
K
W
-
K
P
G
S
L
-
A
S
H
V
K
N
L
D
E
N
G
L
D
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
--
N
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
HHSearch
66.08
28%
-6
- C1 -
-
4AZF
2
DYRK2_HUMAN
A:
[98-413]
--
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
H
K
V
H
Q
H
V
A
L
K
M
V
R
N
E
K
R
F
---
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
N
V
I
----
H
----
M
-----
L
E
N
F
T
------
F
--------
R
--
N
H
I
C
M
T
F
E
L
L
S
M
-
N
L
Y
E
L
I
K
K
N
K
F-
Q
--
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
H
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
--
K
-
Q
---
Q
G
R
S
G
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
-----------------------------------------------------------------------
R
V
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
-
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
-----------
P
L
L
P
G
E
D
-
E
-
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
-
K
L
L
D
A
S
K
R
A
K
N
F
----------
V
S
S
K
G
Y
---
P
R
Y
-
C
T
V
T
T
L
S
D
----
V
V
L
N
G
---
G
R
S
R
R
G
K
L
R
G
P
P
E
S
R
E
W
G
N
A
L
K
G
C
D
D
P
L
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
--
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
65.94
31%
-86
- C1 -
-
4AU8
2
CDK5_HUMAN
A:
[6-293]
-
Q
K
Y
E
K
L
E
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
R
E
T
H
E
I
V
A
L
K
R
V
---------
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
------
H
K
N
I
V
----
R
----
L
-----
H
D
V
L
H
-------------------
K
L
T
L
V
F
E
F
C
D
Q
-
D
L
K
K
Y
F
D
S
C
N
--
G
--
D
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
-
R
---
N
G
E
--
L
K
L
A
D
F
G
L
A
R
A
F
G
I
P
V
--------------------------------------------------------------------
R
--
S
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
-----------
R
P
L
F
P
G
N
D
V
-
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
-
E
Q
W
P
S
M
T
K
L
----------------------
P
D
Y
-
K
P
---------
Y
P
M
----------------
Y
-
P
A
T
T
S
L
V
N
V
V
P
K
L
N
A
T
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
--
S
D
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
HHSearch
65.56
33%
-11
- C1 -
-
4OR5
-
CDK9_HUMAN
F:
[11-312]
-
S
K
Y
E
K
L
A
K
I
G
Q
G
T
F
G
E
V
F
K
A
R
H
R
K
T
G
Q
K
V
A
L
K
K
V
L
M
E
N
E
K
E
G
F
P
I
T
A
L
R
E
I
K
I
L
Q
L
L
K
------
H
E
N
V
V
----
N
----
L
-----
I
E
I
C
R
------
T
KASPYNRC
K
--
G
S
I
Y
L
V
F
D
F
C
E
H
-
D
L
A
G
L
L
S
N
V
L
--
V
--
K
F
T
L
S
E
I
K
R
V
M
Q
M
L
L
N
G
L
Y
Y
I
H
R
N
K
I
L
H
R
D
M
K
A
A
N
V
L
I
--
T
-
R
---
D
G
V
--
L
K
L
A
D
F
G
L
A
R
A
F
S
L
A
K
N
S
----------------------------------------------------------------
Q
P
N
R
Y
T
N
R
V
V
T
L
W
Y
R
P
P
E
L
L
L
G
E
R
D
Y
G
P
P
I
D
L
W
G
A
G
C
I
M
A
E
M
W
T
R
S
-----------
P
I
M
Q
G
N
T
-
E
-
Q
H
Q
L
A
L
I
S
Q
L
C
G
S
I
T
P
-
E
V
W
P
N
V
D
N
Y
--
E
----------------------------
L
Y
E
--
K
L
E
L
V
K
----------
G
Q
K
R
K
-
V
K
D
R
L
---
K
A
Y
V
R
D
P
Y
A
L
D
L
I
D
K
L
L
V
L
D
P
A
Q
R
I
D
S
D
D
A
L
N
H
D
F
F
--
W
S
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
65.52
31%
-58
- C1 -
-
3GC0
1
?
A:
[34-326]
-
D
R
Y
R
R
I
T
K
L
G
E
G
T
Y
G
E
V
Y
K
A
I
D
T
V
T
N
E
T
V
A
I
K
R
I
R
L
E
H
-------
T
A
I
R
E
V
S
L
L
K
E
L
Q
------
H
R
N
I
I
----
E
----
L
-----
K
S
V
I
H
------
H
--------
N
--
H
R
L
H
L
I
F
E
Y
A
E
N
-
D
L
K
K
Y
M
D
K
N
---
P
--
D
V
S
M
R
V
I
K
S
F
L
Y
Q
L
I
N
G
V
N
F
C
H
S
R
R
C
L
H
R
D
L
K
P
Q
N
L
L
L
SV--
E
---
T
P
V
--
L
K
I
G
D
F
G
L
A
R
A
F
-----------------------------------------------------------------------------
E
I
I
T
L
W
Y
R
P
P
E
I
L
L
G
S
R
H
Y
S
T
S
V
D
I
W
S
I
A
C
I
W
A
E
M
L
M
K
T
-----------
P
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
K
I
F
E
V
L
G
L
P
D
D
-
T
T
W
P
-------
G
V
T
A
---------
L
-------
P
---
D
---
W
------------
K
Q
S
F
P
K
------
F
-
R
G
K
T
L
K
R
V
L
G
A
L
L
D
D
E
G
L
D
L
L
T
A
M
L
E
M
D
P
V
K
R
I
S
A
K
N
A
L
E
H
P
Y
F
--
S
H
N
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
65.18
26%
-25
- C1 -
-
2B9F
1
FUS3_YEAST
A:
[12-311]
--
D
F
Q
L
K
S
L
L
G
E
G
A
Y
G
V
V
C
S
A
T
H
K
P
T
G
E
I
V
A
I
K
K
I
E
P
F
D
K
P
L
F
A
-
L
R
T
L
R
E
I
K
I
L
K
H
F
K
-----
H
E
N
I
I
T
IFNI
Q
----
R
-----
P
D
S
F
E
------
N
--------
F
--
N
E
V
Y
I
I
Q
E
L
M
Q
T
-
D
L
H
R
V
I
S
--
T
--
Q
--
M
L
S
D
D
H
I
Q
Y
F
I
Y
Q
T
L
R
A
V
K
V
L
H
G
S
N
V
I
H
R
D
L
K
P
S
N
L
L
I
--
N
-
S
---
N
C
D
--
L
K
V
C
D
F
G
L
-------------------------
A
R
I
I
D
-------------------------------------------------
T
E
Y
V
A
T
R
W
Y
R
A
P
E
V
M
L
T
S
A
K
Y
S
R
A
M
D
V
W
S
C
G
C
I
L
A
E
L
F
L
R
R
-----------
P
I
F
P
G
R
D
-
Y
-
R
H
Q
L
L
L
I
F
G
I
I
G
T
-------------------
P
H
---
S
D
N
D
L
----------------------
R
C
I
E
S
P
R
--
A
R
E
Y
I
K
S
L
P
M
-
Y
P
A
A
P
L
E
K
M
F
P
R
V
N
P
K
G
I
D
L
L
Q
R
M
L
V
F
D
P
A
K
R
I
T
A
K
E
A
L
E
H
P
Y
L
--
Q
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
63.34
29%
11
- C1 -
-
3OZ6
-
?
A:
[9-343]
-
R
K
Y
E
L
V
K
K
-------
I
V
W
K
S
I
D
R
R
T
G
E
V
V
A
V
K
K
I
F
D
--
Q
N
S
T
D
A
Q
R
T
F
R
E
I
M
I
L
T
E
L
S
-----
G
H
E
N
I
V
----
N
----
L
-----
L
N
V
L
R
------
A
--------
D
ND
R
D
V
Y
L
V
F
D
Y
M
E
T
-
D
L
H
A
V
I
R
A
----
N
--
I
L
E
P
V
H
K
Q
Y
V
V
Y
Q
L
I
K
V
I
K
Y
L
H
S
G
G
L
L
H
R
D
M
K
P
S
N
I
L
L
--
N
-
A
---
E
C
H
--
V
K
V
A
D
F
G
L
S
R
S
F
V
N
I
R
R
V
T
N
---------
N
I
----
P
------
L
S
I
----
N
---------------------------------------
Y
V
A
T
R
W
Y
R
A
P
E
I
L
L
G
S
T
K
Y
T
K
G
I
D
M
W
S
L
G
C
I
L
G
E
I
L
C
G
K
-----------
P
I
F
P
G
S
S
-
T
-
M
N
Q
L
E
R
I
I
G
V
I
D
F
P
S
N
-
E
D
V
E
S
I
Q
S
P
---
F
A
K
-----
T
M
---------------
I
E
S
L
K
E
--
K
V
E
----------
K
R
D
I
F
T
K
W
-
K
N
L
L
L
K
I
N
P
K
A
D
C
N
E
E
A
L
D
L
L
D
K
L
L
Q
F
N
P
N
K
R
I
S
A
N
D
A
L
K
H
P
F
V
--
S
I
F
H
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
61.64
27%
-14
- C1 -
-
3NIE
1
?
A:
[28-374]
-
D
N
Y
E
I
K
H
L
I
G
R
G
S
Y
G
Y
V
Y
L
A
Y
D
K
N
A
N
K
N
V
A
I
K
K
V
N
R
M
F
E
D
L
I
D
C
K
R
I
L
R
E
I
T
I
L
N
R
L
K
-----
S
D
Y
I
I
R
----
L
H
D
L
I
I
-----
P
E
D
L
L
------
K
--------
F
--
D
E
L
Y
I
V
L
E
-
I
A
D
-
S
D
L
K
K
L
F
K
T
P
--
I
--
F
L
T
E
Q
H
V
K
T
I
L
Y
N
L
L
L
G
E
K
F
I
H
E
S
G
I
I
H
R
D
L
K
P
A
N
C
L
L
--
N
-
Q
---
D
C
S
--
V
K
I
C
D
F
G
L
A
R
T
I
N
--------------------------------------------------------------------------
T
S
H
V
V
T
R
W
Y
R
A
P
E
L
I
L
L
Q
E
N
Y
T
N
S
I
D
I
W
S
T
G
C
I
F
A
E
L
L
N
M
M
KSHINNPTNRF
P
L
F
P
G
S
S
---------------
C
F
P
-----------
H
E
K
S
N
R
D
Q
L
N
I
I
F
N
V
I
G
T
P
---
P
E
E
D
L
K
C
I
T
K
Q
E
V
I
K
Y
I
K
L
F
P
T
R
D
G
I
D
-------------
L
S
K
K
Y
S
S
-
I
S
K
E
G
I
D
L
L
E
S
M
L
R
F
N
A
Q
K
R
I
T
I
D
K
A
L
S
H
P
Y
L
--
K
D
V
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------