@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_28_1880: (2018-03-11 )
MMDNAGEQLRIVDSTLKRTTPRNCLWYSLVCEGDGFCVLQRPYIAFTLRERLVARPVWTAQEKLCIVYQLLEAVARLHETYGLTHGDIKPNNVLVQSTGVLLLSDMALFKPCQMPLDSPLLFDYYYDTDENRACYVAPEKFSDQPLPTPPPESKTRGSATYNVSNVNFDGHTASMDVFSTACVVLFLYKEEDPLTLSQVLSLRHLANTEAREAFVAPVLRDANVPAALHPLLLPMLCATAEERPSARELVNRGLQQRIFPASLPYLYESVLPRLLTTSPGTRLVLLHNQLEAVLQRCEVLDTTPEGNGGRSSTAAIDAAASAEAVGANAAGLAAVASPSRQLAVSLLLPLLLQTLHSSCTSDEAAYRGLLCLRRCASYCSFTCLVDAVLPHVLFYVNNDAHVYGPSTRLIALRLLSSISEVIAHHLTLRSPQRLSGTVTPSRDAAAAKPGDTGEGSAVPEEQWALMEHLVLPCLYGVLRQAEQESTAVLVEVASRLPRLLLLSRYITERRQLLYGADAVMTKSTTFESRPGPQGHRARQPEDAVHEQQSHHDPLHAKPRRQASQHLSPNKGGEEDHRVKAVAAPVTPNSTSMPPSPLPPPRSSSDALYFSPTDVATLSEQSISGGTRARLAPAARHTEAGKSANEVSDADGENAGDVHGASAAGTQQYLAQLHCLLTNGWSMLQILYNHPCVAVVVEVMQRSSSTVAAFLGEERVTEDLIPLLTTALTAPLRVQRLLYSQAILLHALLQRPPTKTLRLFVDEGLRHTDDVCLNRTLHSLAVVVRSRRLPLEETMALVHQTLPMLVESRLWLREAACGVVEAAAQTYSASDIALHLEYAVRPLLMLPVPLAHLRRYAATAIRAELAMPFMSLGGTAGPTPCSYVSSAPLRERASATGSACLLDEAILEDDEPMNRLLENGTGSGDGRRGRPGQCRGFEDGGGNGGNFKDVLPEVVAVTDSYASAPAPALLHGLPLTEASSSSAPGSRMSREASIAEPAVTAQHSRSATDTCIVADDGGDSDGMALVYRPTAREVARVQLESRSGPLHLPASSALLSPPPSGLTSSHVVAPSTATSSGAAAAAALPVQDCQLPTPPHSRDVSPLPATLPPPSGVIRCSLKGGGGRVLHGRVTPPSLTSPAAAASTAVPPSSSAPCSALRPTAAALSSVSAHMGAIYAAAPSPSANGIVISAGARGEAFVWQVAASHTSTAHARELCLVERVASAASEAGVHTYTACQWIGGPGQRRDFTLSSASASASGSLVAFASTDSAVRVLDVEKNAWVSSTVVGGTPEGGLTGLALQDRASLLVTTAAGGLHVVDTRCRGRGRADEEPAVGSTASVWHTRLNPLDGAPSCVCPLYMSDRACAAAVGTYGGAVCLYDLRYQLCAQRVILVDDGAGLTSASALASGRLSITTACVDPLSTLCRSCRPSSWEPEPAAGPSLLLGTTGGTVYRLLLQSASYWPAFQCCRNGGGAVRTMLTQPTHGCVFTGSEDGYIRSWSTDRPETSHTLVCGLYRSPAYTVERTGAAERALAANAVRGDAVAPPGSNGSKGLASLTVREGSDIHHGGCALPRHAPDAILALCAVRTTTASLASWGSSNSGSGGGGEPCYLLSGSRDGTLTLWDNDPGQP
Atome Classification :
(20 SA)
----------------------------------------------------.........10........-20........30..----.-----.....40....-....50....-----.----...60........70........80.--.......90....--.-.--.---.----100.......110.........120-........130.......140.......150.......160.......170.......180.......-190...-.....200----.-..-.--------..---..210.------------..----.-----...220.......230.......240.......250.......260.....---..270.......280.......290.......300.......310.......320.......330.......340.......350.......360----.......370.......380.--......390.......400........410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710--.......720.......730.......740.......750...-.....760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280...-...1290......1300-----......-..1310......1320......1330......1340......1350......1360......1370......1380.....-----------.1390.---------------------------------------.....1400---------------.........1410......1420......1430......1440......1450......1460......1470......1480......1490......1500......1510......1520......1530......1540......1550......1560......1570......1580......1590......1600......1610......1620.....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
----------------------------------------------------MMDNAGE
Q
L
R
I
V
D
S
T
L
KRT-TPRN
C
L
W
Y
S
L
V
CEG----D-----
G
F
C
V
L
QR
P
Y
I
A
-
F
T
L
R
E
R
L
VAR-----P----VW
T
A
Q
E
K
L
C
I
V
Y
Q
L
L
E
A
V
A
R
L
H
E
T
YG--LTHGDIKPN
N
V
L
V
--Q-S--T---
G
----
V
L
L
LSD
M
A
LFK--PCQMPLDS
P
L
L
--
F
D
Y
YYDTDEN
R
A
C
Y
VA
P
E
KFSDQPLPTPPPESKTRGS
A
T
Y
N
V
S
N
V
NFDGHT
A
S
M
D
V
F
S
T
A
C
V
V
L
F
L
YK-E-EDPL-
T
L
S
Q
V
L
S
-----
L
-
R
H
-L--------AN---
T
E
A
R
E
A
------------
F
V
----
A
-----
P
V
L
RDANVP
A
A
L
H
P
L
L
L
P
M
L
CATAEERP
S
A
R
E
L
V
N
R
G
L
Q
QRIFPAS
L
P
Y
L
Y
---
E
S
V
L
P
R
L
LTTSPG
T
R
L
V
L
L
H
N
Q
L
E
A
V
L
Q
R
C
E
VLDTTPEGNGGRSS
T
A
A
IDAAASAEAVGANAAG
L
A
AVASP
S
R
Q
L
A
V
S
L
L
L
P
L
L
L
Q
T
L
H
SSCT
S
D
----
E
A
A
Y
R
G
L
L
C
L
R
R
C
A
S
Y
C
S
F
T
C
--
L
V
D
A
V
L
P
H
V
L
F
Y
VNNDA-
H
V
YGPS
T
R
L
I
A
L
R
L
L
S
S
I
S
E
V
I
A
H
H
L
TLR
S
P
Q
RLSGTVTPSRDAAAAKPGDTGEGSAV
P
E
E
Q
W
A
L
M
E
H
L
V
L
P
C
L
Y
G
V
L
R
Q
A
EQ
E
S
T
A
V
L
V
E
V
A
S
R
L
P
R
L
L
L
L
S
R
Y
I
T
E
R
R
Q
L
L
YGAD
A
V
M
TKSTTFESRPGPQGHRARQ
P
E
D
A
V
H
E
Q
QSHHDPLH
A
K
P
R
R
Q
A
S
QHLSPNKGGEED
H
R
V
K
A
V
AAPVTPNSTSMPPSPLPPPRSSS
D
A
L
Y
FSPTD
V
A
T
LSEQSISGGTRARLAPAARHTEAGKSANEVSDADGENAGDVHGASAA
G
T
Q
Q
Y
L
A
Q
L
H
C
L
LTN
G
W
S
M
L
Q
I
L
YNHP
C
V
A
V
V
V
E
V
M
Q
RSS
S
T
V
A
A
F
LG
E
--
E
R
V
T
E
D
L
I
P
L
L
T
T
A
LT
A
P
L
R
V
Q
R
L
L
Y
S
Q
A
I
L
L
H
A
L
L
QRP-P
T
K
-
T
L
R
L
F
V
D
EGLRH
T
D
D
V
C
L
N
R
T
L
H
S
L
A
V
V
V
R
SRRL
P
L
E
E
T
M
A
L
V
H
Q
T
L
P
M
L
V
E
S
R
L
W
L
R
E
AA
C
G
V
V
E
A
A
A
QTYSAS
D
I
A
L
H
L
E
YAVR
P
L
L
MLPV
P
L
A
H
L
R
R
Y
A
A
T
A
I
R
A
E
L
A
M
P
F
M
SLGGTAGPTP
C
S
YVSSAP
L
R
E
R
ASATG
S
A
C
L
L
D
E
A
ILED
D
E
P
M
N
R
L
L
ENGTGSGDGRRGRPGQCRGFEDGGGNGG
N
F
K
D
V
L
P
E
V
V
A
VTDSYASA
P
A
P
A
L
L
HGLPLTEASSSSAPGSRMSREASIAEP
A
V
T
AQHSRSAT
D
T
C
I
V
ADDGGDSD
G
M
A
L
V
YRPTA
R
E
V
A
R
V
Q
L
ESRSG
P
L
HLPASSALLSPPPSGLTSS
H
V
VAPSTATSSGAA
A
A
A
ALPVQDCQLPTPPHSRDVSPLPATLPPPS
G
V
I
R
C
S
L
KGGG
G
R
V
L
HGRVTPPSLTSPAAAASTAVPPSSSAPCSAL
R
P
T
A
A
A
L
S
S
V
S
A
H
M
G
A
I
Y
AAAPSPSA
N
G
I
V
I
SAGARG
E
A
F
V
W
Q
V
AASHTS
T
A
H
A
R
E
L
C
L
V
E
R
V
A
S
A
A
S
EAGV
H
T
Y
T
A
C
Q
WIGGPGQR
R
D
F
T
LSSASASASG
S
L
V
A
F
ASTD
S
A
V
R
V
L
DVEKNAWVSSTVVG-GTPEGG
L
T
G
L
ALQDR-------
A
S
L
L
V
T
-TAAG
G
L
H
V
V
DTRCRGRGRADEEPAVGS
T
A
S
V
W
H
TRLNPLDGAPS
C
V
C
P
LYMSD
R
A
C
A
A
A
VGTYGG
A
V
C
L
Y
D
L
R
Y
Q
L
C
AQ
R
V
-----------
I
L
VDDG---------------------------------------AGL
T
S
A
------------------
S
A
LASG
R
L
S
I
T
T
A
C
V
D
P
L
S
T
L
C
R
SCRPSSWEPEPAAGP
S
L
L
L
GTT
G
G
T
V
Y
R
L
L
L
QSASY
W
P
A
F
Q
C
C
RNGGG
A
V
R
T
M
LTQPTH
G
C
V
F
TGSEDG
Y
I
RSWSTDRPETS
H
T
L
V
C
G
LYRSP
A
Y
T
V
ERTGAA
E
R
A
L
A
ANAVRGDAVAPPGSNGSKG
L
A
S
L
T
VREGSDIHHGGCALPRHA
P
D
A
I
L
A
L
C
A
V
RT
T
T
A
S
L
ASWGSSNSGSGGGGE
P
C
Y
L
L
SGSRD
G
T
L
T
LWDNDPGQP
23
Fugue
57.88
18%
3
- C3 -
-
5DFZ
-
VPS15_YEAST
B:
[10-1454]
QASPSIAIFSYIDVLEEVHYVSQLNSSRFLKTCKALDPNGEIVIKVFIKPKD
Q
Y
S
L
R
P
F
L
Q
R
I
R
A
Q
S
F
K
L
G
-
Q
L
P
H
V
L
N
Y
S
K
L
I
E
T
----
N
-----
R
A
G
Y
M
I
R
Q
H
L
K
-
N
N
L
Y
D
R
L
S
L
R
-----
P
----
Y
L
Q
D
I
E
L
K
F
I
A
F
Q
L
L
N
A
L
K
D
I
H
N
L
-
N
--
I
V
H
G
D
I
K
T
E
N
I
L
V
--
T
-
S
--
W
---
N
----
W
C
I
L
T
D
F
A
A
F
T
---------------------------
C
Y
L
A
P
E
R
F
N
S
K
L
---------------
Y
Q
D
G
K
S
N
N
G
R
L
T
K
E
M
D
I
F
S
L
G
C
V
I
A
E
I
F
A
-
E
-
G
R
P
I
F
N
L
S
Q
L
F
K
-----
Y
-
K
S
-
N
--------
S
Y
-------------------------------------
D
V
N
R
S
T
D
L
R
N
L
V
L
D
M
I
Q
L
D
P
S
K
R
L
S
C
D
E
L
L
N
K
Y
R
G
I
F
F
P
D
Y
F
Y
T
F
I
Y
---
D
Y
F
R
N
L
V
T
M
T
N
T
C
T
N
------------------------------------------------------------------
S
T
L
E
D
N
V
K
L
L
D
E
T
T
----
E
K
I
Y
R
D
F
S
Q
I
C
H
C
L
D
------------------
F
P
L
I
K
D
G
-
G
E
I
G
S
D
P
P
I
L
---------------
L
V
L
Q
Q
F
T
K
V
S
E
K
I
K
S
V
K
E
E
C
A
L
-----------------------------
L
F
I
S
Y
L
S
H
S
I
R
S
I
V
S
T
A
T
K
L
K
N
L
E
L
L
A
V
F
------------
A
Q
F
V
S
D
E
N
K
I
D
R
V
V
P
Y
F
V
C
C
F
E
D
S
D
Q
D
V
Q
A
L
S
L
L
T
L
I
Q
V
L
T
S
V
R
K
L
N
Q
L
--
N
E
N
I
F
V
D
Y
L
L
P
R
L
K
R
L
L
I
S
N
R
Q
N
T
N
--------------
Y
L
R
I
V
F
A
N
C
L
S
D
L
A
I
I
I
N
R
F
Q
E
F
T
F
A
Q
H
C
N
D
N
S
S
T
K
Y
S
A
K
L
I
Q
S
V
E
D
L
T
V
S
F
L
T
D
N
D
T
Y
V
K
M
A
L
L
Q
------------------------
N
R
E
R
T
N
D
I
I
L
S
H
L
I
T
--
Y
L
N
D
K
D
--
P
A
L
R
V
S
L
I
Q
T
I
S
G
I
S
I
L
L
G
T
V
T
L
E
Q
Y
I
L
P
L
L
-
I
----------
Q
T
I
T
D
S
E
E
L
V
V
I
S
V
L
Q
S
L
K
S
L
F
K
T
G
L
I
R
K
K
Y
Y
I
D
I
S
K
T
T
S
P
L
L
L
H
P
N
N
W
I
R
Q
F
T
L
M
I
I
I
E
I
I
N
K
L
S
K
A
E
V
Y
C
I
L
Y
P
I
I
V
-------------
E
F
N
F
K
S
M
I
S
C
C
K
Q
P
V
S
R
-------------
S
V
Y
N
L
L
C
S
W
S
V
R
A
S
K
S
L
F
W
K
K
I
I
T
N
H
V
D
S
F
-----
G
N
N
R
I
E
F
I
T
K
S
T
V
Y
S
H
D
N
K
E
-----------------
I
P
L
T
A
E
D
R
N
W
I
D
K
F
H
I
I
G
L
T
E
K
D
----
I
W
K
I
V
A
L
R
G
Y
V
I
R
T
A
R
V
M
A
A
N
P
N
L
K
N
V
-------------------------
F
V
Q
L
E
P
T
S
Y
H
M
H
S
P
N
H
G
--
L
K
D
N
A
N
V
K
P
E
R
K
V
V
V
S
N
S
Y
E
G
D
V
E
S
I
E
K
F
L
S
T
F
K
-
I
L
P
P
L
R
D
Y
K
E
F
G
P
I
Q
E
I
V
R
S
P
N
M
-----------
G
N
L
R
G
K
L
I
A
T
L
M
E
N
E
--------------------
P
N
S
I
T
S
S
A
V
S
------------
P
G
E
T
P
Y
L
I
T
G
S
D
Q
G
V
I
K
I
W
N
L
K
E
I
I
V
G
E
V
Y
S
S
S
L
T
Y
D
C
S
----------
S
T
V
T
Q
I
T
M
I
P
N
F
D
A
---
F
A
V
S
S
K
D
G
Q
I
I
V
L
K
V
N
H
Y
Q
Q
E
S
E
V
K
F
L
N
C
E
C
I
R
K
I
N
L
K
N
F
G
K
N
E
Y
A
V
R
M
R
A
F
V
N
E
E
K
-------
S
L
L
V
A
L
-
T
N
L
S
R
V
I
I
F
D
I
R
T
L
E
R
L
Q
I
I
E
N
S
--------------
P
R
H
G
A
V
S
---
S
I
C
I
D
E
E
C
C
V
L
I
L
G
T
T
R
G
I
I
D
I
W
D
I
R
F
N
V
L
I
R
S
W
-----------
S
F
G
D
H
A
---------------------------------------
P
I
T
H
V
E
------------------
V
C
Q
F
Y
G
K
N
S
V
I
V
V
G
G
S
S
------
K
T
F
L
T
I
W
N
F
V
K
G
H
C
Q
Y
A
F
I
N
S
D
E
Q
P
S
M
E
H
F
L
P
I
E
K
G
L
E
E
L
N
F
C
G
I
R
S
L
N
A
L
S
T
I
S
V
S
N
D
K
I
L
L
T
D
E
A
T
S
S
I
V
M
F
S
L
N
E
L
S
S
S
K
A
V
I
S
P
S
R
F
S
D
V
F
I
P
T
Q
V
T
A
------------------------
N
L
T
M
L
L
R
K
M
K
S
L
Y
H
H
D
-------------
I
I
N
S
I
S
T
C
E
V
---------------
D
E
T
P
L
L
V
A
C
D
N
S
G
L
I
G
I
F
Q
------
10
PsiBlast_PDB
43.54
35%
-229
- C2 -
-
1BLX
-
CDK6_HUMAN
A:
[125-185]
-----------------------------------------------------------------------------------------------------------------------------------------
M
M
F
Q
L
L
R
G
L
D
F
L
H
-
S
H
R
--
V
V
H
R
D
L
K
P
Q
N
I
L
V
--
T
-
S
--
S
---
G
----
Q
I
K
L
A
D
F
G
L
A
R
I
Y
S
F
Q
M
A
L
T
S
V
V
V
--
T
L
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
HHSearch
41.59
21%
-77
- C2 -
-
5K00
1
MELK_HUMAN
A:
[51-263]
----------------------------------------------------------
P
R
I
K
T
E
I
E
A
L
K
N
L
-
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
----
A
-----
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
-----
D
----
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
-
Q
G
--
Y
A
H
R
D
L
K
P
E
N
L
L
F
--
D
-
E
--
Y
---
H
----
K
L
K
L
I
D
F
G
L
C
A
--
K
P
---------------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
S
Y
------------------------
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
-
G
-
F
L
P
F
-
D
D
D
N
V
M
A
-----
L
-
Y
K
-
K
--------
I
M
---
R
G
K
---------------------------
Y
-
D
V
P
K
W
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
L
L
N
H
P
W
I
M
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
41.43
12%
-43
- C2 -
-
3VWA
-
CEX1_YEAST
A:
[57-531]
----------------------------------------------------------
S
L
I
L
N
A
V
H
K
S
K
I
L
-
K
I
P
G
L
C
T
V
L
E
T
F
D
S
----
D
P----
Q
S
T
F
I
V
T
E
R
V
V
-
P
F
P
W
D
N
L
G
-
S
-----
L
----
S
Q
N
K
F
G
V
E
L
G
I
S
Q
L
L
A
T
L
G
F
L
K
N
-----
F
V
L
G
T
L
S
K
D
S
V
F
I
--
N
-
I
--
K
---
G
----
E
W
V
L
F
G
L
E
L
C
S
--
S
K
E
G
L
--
S
A
-------
F
E
F
A
S
R
A
R
S
Y
Y
N
I
I
G
S
Q
L
P
C
-------------------------
E
D
P
N
T
I
D
S
M
G
L
G
L
L
I
K
S
L
M
A
-
P
S
C
L
P
----------------------------------------------------------------------------
K
D
W
I
V
N
V
N
M
I
S
D
G
K
I
T
I
E
N
F
R
K
R
-
L
E
N
T
E
--
T
W
R
S
N
P
L
I
N
F
Y
Q
E
L
R
E
L
H
I
K
D
P
Q
G
K
L
V
V
-
M
S
N
L
E
N
L
Y
L
E
S
R
E
I
F
----------------------------
R
------
N
L
T
P
G
M
I
E
N
F
I
I
P
E
L
C
E
I
I
K
L
L
M
-
T
Q
S
I
SS-
N
A
S
H
K
L
V
P
F
L
A
I
V
L
D
L
T
S
E
T
NT
F
P
V
G
F
N
D
L
I
T
Q
S
F
K
L
P
D
R
Q
V
-----
R
F
L
L
L
I
Y
L
P
K
L
I
G
P
L
S
K
---------------------------------------
S
E
I
S
S
R
I
Y
P
H
F
I
Q
G
L
T
D
---
S
D
A
T
L
R
L
Q
T
L
K
T
I
P
C
I
V
S
C
L
T
---
E
R
-
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
N
E
L
L
R
F
L
A
K
T
Q
V
D
S
D
V
E
I
R
T
W
T
V
I
I
I
S
K
-
I
S
T
I
L
S
T
S
V
G
N
R
S
N
I
L
A
T
A
F
T
K
S
L
K
D
P
Q
V
K
P
R
L
A
A
L
Y
G
L
E
K
S
I
E
L
F
D
V
N
T
I
A
N
K
I
L
T
V
I
A
P
G
L
L
D
K
S
P
I
V
R
G
R
A
K
I
L
F
E
E
Y
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
41.27
18%
-31
- C2 -
-
2X0G
-
DAPK1_HUMAN
A:
[59-275]
----------------------------------------------------------
E
D
I
E
R
E
V
S
I
L
K
E
I
-
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
----
K
-----
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
-----
E
----
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
-
L
Q
--
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
-
D
--
R
---
N
VP
K
P
R
I
K
I
I
D
F
G
L
A
H
--
K
I
D
F
G
N
----------
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
P
-------------------------
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
-
G
-
A
S
P
F
-
L
G
D
T
K
Q
E
-----
T
-
L
A
-
N
--------
V
S
---
A
V
N
-
Y
E
-------------
F
----
E
-----
D
-
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
HHSearch
41.23
23%
-31
- C2 -
-
2PSQ
-
B:
[131-361]
----------------------------------------------------------
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
----
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
RPPGE
E
----
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
-
Q
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
--
T
-
E
--
N
---
N
----
V
M
K
I
A
D
F
G
L
A
R
--
D
I
N
N
I
D
Y
Y
-------
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
-------------------------
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
-
G
S
P
Y
-
P
G
I
P
V
E
E
-----
L
-
F
K
-
L
--------
L
K
---
E
G
H
R
--------------------------
M
-
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
-
L
D
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
40.56
14%
-72
- C2 -
-
5J5T
1
M4K3_HUMAN
A:
[46-266]
----------------------------------------------------------
A
V
V
Q
Q
E
I
I
M
M
K
D
C
-
K
H
P
N
I
V
A
Y
F
G
S
Y
L
R
----
R
-----
D
K
L
W
I
C
M
E
F
C
G
G
G
S
L
Q
D
I
Y
H
V
T
-----
G
----
P
L
S
E
L
Q
I
A
Y
V
S
R
E
T
L
Q
G
L
Y
Y
L
H
S
-
K
G
--
K
M
H
R
D
I
K
G
A
N
I
L
L
--
T
-
D
--
N
---
G
----
H
V
K
L
A
D
F
G
V
S
A
--
Q
I
T
A
T
I
A
------------
A
F
I
G
T
P
Y
W
M
A
P
E
V
A
A
V
E
R
K
----------------------
G
G
Y
N
Q
L
C
D
L
W
A
V
G
I
T
A
I
E
L
A
E
-
L
-
Q
P
P
M
-
F
D
L
H
P
M
R
-----
A
-
L
F
-
L
--------
M
T
---
K
S
N
F
-
Q
------------
P
-----
P
-----
K
L
K
D
K
M
K
W
S
N
S
F
H
H
F
V
K
M
A
L
T
K
N
P
K
K
R
P
T
A
E
K
L
L
Q
H
P
F
V
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
HHSearch
39.94
19%
-34
- C2 -
-
4IDV
1
M3K14_HUMAN
A:
[115-329]
--------------------------------------------------------------
E
E
L
M
A
C
A
G
L
-
T
S
P
R
I
V
P
L
Y
G
A
V
R
E
----
G
-----
P
W
V
N
I
F
M
E
L
L
E
G
G
S
L
G
Q
L
V
K
E
Q
-----
G
----
C
L
P
E
D
R
A
L
Y
Y
L
G
Q
A
L
E
G
L
E
Y
L
H
S
-
R
R
--
I
L
H
G
D
V
K
A
D
N
V
L
L
--
S
-
S
--
D
---
G
S---
H
A
A
L
C
D
F
G
H
A
V
--
C
L
Q
P
D
G
L
G
K
S
----
L
L
T
G
D
Y
I
P
G
T
E
T
H
M
A
P
E
V
V
L
G
R
S
-------------------------
C
D
A
K
V
D
V
W
S
S
C
C
M
M
L
H
M
L
N
-
G
-
C
H
P
W
-
T
Q
F
F
R
G
P
-----
L
-
C
L
-
K
--------
I
A
---
S
E
P
P
---------------
P
----------
V
R
E
I
P
P
S
C
A
P
L
T
A
Q
A
I
Q
E
G
L
R
K
E
P
I
H
R
V
S
A
A
E
L
G
G
K
-
V
N
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
HHSearch
37.05
18%
-27
- C2 -
-
3RP9
-
?
A:
[97-402]
----------------------------------------------------------
K
R
I
L
R
E
I
A
I
L
N
R
L
-
N
H
D
H
V
V
K
V
L
D
I
V
I
P
----
K
DVEKF
D
E
L
Y
V
V
L
E
I
A
D
-
S
D
F
K
K
L
F
R
T
P
-----
V
----
Y
L
T
E
L
H
I
K
T
L
L
Y
N
L
L
V
G
V
K
Y
V
H
S
-
A
G
--
I
L
H
R
D
L
K
P
A
N
C
L
V
--
N
-
Q
--
D
---
C
----
S
V
K
V
C
D
F
G
L
A
R
--
T
V
D
Y
P
E
N
G
N
S
Q
LP---------
V
T
R
W
Y
R
A
P
E
L
I
L
L
Q
E
------------------------
N
Y
T
E
A
I
D
V
W
S
I
G
C
I
F
A
E
L
L
N
-
M
-
I
K
E
N
-
V
A
Y
H
A
D
R
GPLFP----T
R
G
N
R
D
Q
L
N
V
I
F
N
I
L
G
T
P
S
E
E
D
I
E
A
LEK
E
D
A
K
R
Y
I
R
I
F
P
K
R
E
G
T
D
L
A
E
R
F
P
A
S
S
A
D
A
I
H
L
L
K
R
M
L
V
F
N
P
N
K
R
I
T
I
N
E
C
L
A
H
P
F
F
K
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
HHSearch
36.64
21%
-35
- C2 -
-
2WEL
7
KCC2D_HUMAN
A:
[47-268]
---------------------------------------------------------
H
Q
K
L
E
R
E
A
R
I
C
R
L
L
-
K
H
P
N
I
V
R
L
H
D
S
I
S
E
----
E
-----
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
-----
E
----
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
-
N
G
--
I
V
H
R
D
L
K
P
E
N
L
L
L
--
A
-
S
--
K
SKG
A
----
A
V
K
L
A
D
F
G
L
A
I
--
E
V
Q
G
D
Q
Q
---------
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
D
P
-------------------------
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
-
G
-
Y
P
P
F
-
W
D
E
D
Q
H
R
-----
L
-
Y
Q
-
Q
--------
I
K
---
A
G
A
-
Y
D
------------
F
-----------
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
HHSearch
36.37
14%
-43
* C3 *
-
4WJV
-
NLE1_YEAST
C:
[4-343]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
I
A
G
H
G
S
T
I
L
C
S
A
F
A
P
H
T
S
S
R
M
V
T
G
A
G
D
N
T
A
R
I
W
D
C
D
T
Q
T
P
M
H
T
--------------------------------
L
K
G
H
Y
N
W
V
L
C
V
S
W
S
P
D
G
E
V
I
A
T
G
S
M
D
N
T
I
R
L
W
D
P
K
S
G
Q
C
L
G
D
A
L
R
---
G
H
S
K
W
I
T
S
L
S
W
E
P
I
HLVKPGS
K
P
R
L
A
S
S
S
K
D
G
T
I
K
I
W
D
T
V
S
R
V
C
--------------
Q
Y
T
-----
M
S
G
H
T
N
S
V
S
C
V
K
W
G
G
-
Q
G
L
L
Y
S
G
S
H
D
R
T
V
R
V
W
D
I
N
S
Q
G
R
C
I
N
I
LKSHAHWVNHL
S
L
S
T
D
Y
ALRIGAFDHTGKKPSTPEEAQKKALENYEKICKKNGNSE
E
M
M
V
T
A
SDDYTMFLWNPLKSTKPI
A
R
M
T
G
H
Q
K
L
V
N
H
V
A
F
S
P
------------------
D
G
R
Y
I
V
S
A
S
F
D
N
S
I
K
L
W
D
G
R
D
G
K
---
F
I
S
T
F
R
G
H
V
A
S
V
Y
Q
V
A
W
S
S
D
C
R
L
L
V
S
C
S
K
D
T
T
L
K
V
W
D
V
R
T
R
K
-----------------------------------------------------------------------------------------------------------------------------
41
HHSearch
35.98
15%
-9
- C2 -
-
2X4F
4
MYLK4_HUMAN
A:
[130-346]
---------------------------------------------------------
K
E
E
V
K
N
E
I
S
V
M
N
Q
L
-
D
H
A
N
L
I
Q
L
Y
D
A
F
E
S
----
K
-----
N
D
I
V
L
V
M
E
Y
V
D
G
G
E
L
F
D
R
I
I
D
E
S----
Y
----
N
L
T
E
L
D
T
I
L
F
M
K
Q
I
C
E
G
I
R
H
M
H
Q
-
M
Y
--
I
L
H
L
D
L
K
P
E
N
I
L
C
VN
R
-
D
--
A
---
K
----
Q
I
K
I
I
D
F
G
L
A
R
--
R
Y
K
P
R
E
K
----------
L
K
V
N
F
G
T
P
E
F
L
A
P
E
V
V
N
Y
D
F
-------------------------
V
S
F
P
T
D
M
W
S
V
G
V
I
A
Y
M
L
L
S
-
G
-
L
S
P
F
-
L
G
D
N
D
A
E
-----
T
-
L
N
-
N
--------
I
L
---
A
C
R
---------------
W
D
----
L
-----
E
D
E
E
F
Q
D
I
S
E
E
A
K
E
F
I
S
K
L
L
I
K
E
K
S
W
R
I
S
A
S
E
A
L
K
H
P
W
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
35.88
17%
-11
- C2 -
-
1TKI
-
TITIN_HUMAN
A:
[63-279]
----------------------------------------------------------
V
L
V
K
K
E
I
S
I
L
N
I
A
-
R
H
R
N
I
L
H
L
H
E
S
F
E
S
----
M
-----
E
E
L
V
M
I
F
E
F
I
S
G
L
D
I
F
E
R
I
N
T
S
-----
A
F
---
E
L
N
E
R
E
I
V
S
Y
V
H
Q
V
C
E
A
L
Q
F
L
H
S
-
H
N
--
I
G
H
F
D
I
R
P
E
N
I
I
Y
--
Q
-
T
RR
S
---
S
----
T
I
K
I
I
E
F
G
Q
A
R
--
Q
L
K
P
G
D
----------
N
F
R
L
L
F
T
A
P
E
Y
Y
A
P
E
V
H
Q
H
D
V
-------------------------
V
S
T
A
T
D
M
W
S
L
G
T
L
V
Y
V
L
L
S
-
G
-
I
N
P
F
-
L
A
E
T
N
Q
Q
-----
I
-
I
E
-
N
--------
I
M
---
N
A
E
Y
-
T
------------
F
-----------
D
E
E
A
F
K
E
I
S
I
E
A
M
D
F
V
D
R
L
L
V
K
E
R
K
S
R
M
T
A
S
E
A
L
Q
H
P
W
L
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
35.85
35%
-161
- C2 -
-
1BI8
-
CDK6_HUMAN
A:
[125-185]
-----------------------------------------------------------------------------------------------------------------------------------------
M
M
F
Q
L
L
R
G
L
D
F
L
H
-
S
H
R
--
V
V
H
R
D
L
K
P
Q
N
I
L
V
--
T
-
S
--
S
---
G
----
Q
I
K
L
A
D
F
G
L
A
R
I
Y
S
F
Q
M
A
L
T
S
V
V
V
--
T
L
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
HHSearch
35.76
17%
-33
- C2 -
-
3C0G
1
CSKP_HUMAN
B:
[70-290]
---------------------------------------------------------
T
E
D
L
K
R
E
A
S
I
C
H
M
L
-
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
----
D
-----
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
-----
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
-
N
N
--
I
I
H
R
D
V
K
P
H
C
V
L
L
--
A
-
S
--
K
---
E
NS
A
-
P
V
K
L
G
G
F
G
V
A
I
--
Q
L
G
E
S
G
L
---------
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
R
E
P
-------------------------
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
-
G
-
C
L
P
F
-
Y
G
T
K
E
R
L
-----
F
-
E
G
-
I
--------
I
K
---
G
K
Y
K
---------------
M
----------
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
35.06
35%
-147
- C2 -
-
2EUF
1
CDK6_HUMAN
B:
[125-199]
-----------------------------------------------------------------------------------------------------------------------------------------
M
M
F
Q
L
L
R
G
L
D
F
L
H
-
S
H
R
--
V
V
H
R
D
L
K
P
Q
N
I
L
V
--
T
-
S
--
S
---
G
----
Q
I
K
L
A
D
F
G
L
A
R
I
Y
S
F
Q
M
A
L
T
S
V
V
V
--
T
L
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
HHSearch
34.96
19%
-25
- C2 -
-
5O2C
4
WNK3_HUMAN
A:
[68-286]
---------------------------------------------------------
Q
Q
R
F
K
E
E
A
E
M
L
K
G
L
-
Q
H
P
N
I
V
R
F
Y
D
S
W
E
S
I
L
KG
K
-----
K
C
I
V
L
V
T
E
L
M
T
S
G
T
L
K
T
Y
L
K
R
F
-----
K
----
V
M
K
P
K
V
L
R
S
W
C
R
Q
I
L
K
G
L
Q
F
L
H
T
-
R
T
PP
I
I
H
R
D
L
K
C
D
N
I
F
I
--
T
G
P
--
T
---
G
----
S
V
K
I
G
D
L
G
L
A
T
--
L
M
R
T
S
-----------
F
A
K
S
V
I
G
T
P
E
F
M
A
P
E
M
Y
E
E
H
--------------------------
Y
D
E
S
V
D
V
Y
A
F
G
M
C
M
L
E
M
A
T
-
S
-
E
Y
P
Y
-
S
E
C
Q
N
A
A
-----
Q
I
Y
R
-
K
--------
V
T
---
S
G
I
K
--------------------------
P
A
S
F
N
K
V
T
D
P
E
V
K
E
I
I
E
G
C
I
R
Q
N
K
S
E
R
L
S
I
R
D
L
L
N
H
A
F
F
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
34.93
35%
-137
- C2 -
-
1XO2
1
CDK6_HUMAN
B:
[125-188]
-----------------------------------------------------------------------------------------------------------------------------------------
M
M
F
Q
L
L
R
G
L
D
F
L
H
-
S
H
R
--
V
V
H
R
D
L
K
P
Q
N
I
L
V
--
T
-
S
--
S
---
G
----
Q
I
K
L
A
D
F
G
L
A
R
IY
S
F
Q
M
A
L
T
S
V
V
V
--
T
L
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
34.90
32%
-136
- C2 -
-
5B2L
-
MP2K7_HUMAN
A:
[125-196]
---------------------------------------------------------------------------------------------------------------------------------------------
I
V
K
A
L
Y
Y
L
K
E
K
H
G
--
V
I
H
R
D
V
K
P
S
N
I
L
L
--
D
-
E
--
R
---
G
----
Q
I
K
L
C
D
F
G
I
-----------
S
G
-------------
G
C
A
A
Y
M
A
P
E
R
I
-
D
P
P
D
P
T
K
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
HHSearch
34.31
17%
-62
- C2 -
-
4XBR
1
INKA1_HUMAN (first)
A:
[136-348]
----------------------------------------------------------
E
L
L
F
N
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
----
G
-----
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
T
----------
R
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
-
Q
G
--
V
I
H
R
D
I
K
S
D
S
I
L
L
--
T
-
H
--
D
---
G
----
R
V
K
L
S
D
F
G
F
C
A
--
Q
V
S
K
E
V
P
R
---------
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
R
L
P
-------------------------
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
-
G
-
E
P
P
Y
-
F
N
E
P
P
L
K
-----
A
-
M
K
-
M
--------
I
R
---
D
N
L
P
P
-------------------------
R
L
K
N
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------