@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_28_2140: (2018-03-11 )
MTTRKVIGDVVQYRLDTPIASGAFSTVWRCSELSSGRTYAVKIVEKKAALRNKMTGALIREVNALEIAGSSPYVTGLVDKMVSKHNYYLVMELAEGGTLLDLIRERRQELRQLQVSSSTGCSVMDSLQLSATPFMPYDRVRYYFKQLLLALSALHDRNVVHRDVKPENILLNKQRTRLLLSDFGFACHSMLGAQLHRACGTLKYCAPELLREHPSYDGRKVDVWAAGITLYMMLFGGYPYRCSRGDPDALLEVIETTTYRIPRPIPALIEDILQHMLCIDAAQRWSVKQLLQHPWISELELHSPSASPATSASSFSGEELASPAASVLETEGAITEMPSEDCPPVDSLPSDGDEVDDGFYQSINHGHLSSSASSGLNSSTISTQQPRQRSSLADSRRSHKEAFPLAVSPASPLHCGDPDVVQGGESETPGASKAFVVQPPTRSSSASAKEEILKYGIEFTSLTSIESFVASDGEGEMDDSEDESLFWEEMREGAATRGHCGNTSMSSSLYTGASHVGDVQQSGLRGRYSYGLWLTARMAAHLVAFIAVCVVALALRVLLKREISDLPLPKGIRDYISFLYTPPRRPHAHRSGAAPTLCHSRGGPPTASALVLRQKGSYGDSSASCPPTASPIPGSGLRHYVRTADKLMRDSLMGNVVLSHNAPLVDFAYGKMPEPCPRKHSKDRSLSSTPAAPSLATVAPTQSSTRRQSLERSEASTAEAYAENVELSALPLPLNSEKRRENTNRLVSPGGGDEEGCNEQRDRQGSDSSLRKERRSTRSSPPPLMSVGDPISATTAAITSLRTLTSSKTPVRSEVRVDSQAGATDDTGSCDSALDKSAYSPHQNIMFSPLDPMPMALGDHQHEMEDFPVVAKTGHA
Atome Classification :
(21 SA)
.........10........20........30........40........50----..-----.......60........70........80........90........100.......110.......120.......130.......140.......150....-...160.......170-.....---...-180.......190.-.-......200.......210----..----......220.......230.......240....-...250.......----260---.----..----.....270---........280...-----..------.-.290....------...300....-------...310.......320...--------....330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
T
T
R
K
V
I
G
D
V
V
Q
Y
RLDTPIAS
G
A
F
S
T
V
W
R
C
S
ELSSG
R
T
Y
A
V
K
I
V
E
K
K
A
A
L
-----
R
N
-----
K
M
T
G
A
L
I
REV
N
A
L
E
IAGSSP
Y
V
T
G
L
V
D
K
M
VSKH
N
Y
Y
L
V
M
E
LAEG
G
T
L
L
D
L
I
R
E
R
R
Q
E
L
R
Q
L
QVSSSTGC
S
V
M
D
SLQLSATPFMP
Y
D
R
V
R
Y
Y
F
K
Q
L
L
L
A
L
S
A
L
HD-RNVVHRDVKPE
N
I
L
L--
N
K
Q
R
T
---
R
L
L
-
L
S
D
F
G
F
A
C
H
S
M
L
-
G
-
A
-
Q
L
H
R
A
CG
T
L
K
Y
C
A
P
E
L
L
R
-----EH----PSYDG
R
K
V
D
V
W
A
A
G
I
T
L
Y
M
M
L
FGGYPYRCSRG
D
-
P
D
A
L
L
E
V
I
E
T
TTY----RI----P----RP----
I
P
A
L
I
E
D
----
I
L
Q
H
M
L
C
I
D
A
A
Q
R
W
-----
S
V
------
K
-
Q
L
L
QHPWI------S
E
L
E
LHSPSA-------SPATSASSFS
G
E
E
LA
S
P
A
A
--------
S
V
L
ETEGAITEMPSEDCPPVDSLPSDGDEV
D
D
G
F
Y
Q
SINHGHLSSSASSGLNSSTISTQQP
R
Q
R
S
S
L
A
D
S
R
R
SHKEAF
P
L
AVSPASPLHCGD
P
D
V
VQGGESETPGAS
K
A
F
V
VQPPTRSSS
A
S
A
K
E
E
I
L
K
YGIEFT
S
L
T
S
I
E
S
F
V
ASDGEGEMDDSED
E
S
L
F
W
E
E
M
R
EGAATRGHCGNTSMSSSLYTGA
S
H
V
G
D
V
Q
Q
SGLRGR
Y
S
YG
L
W
L
T
A
R
M
A
A
H
L
V
A
F
I
A
V
C
V
V
A
L
A
L
R
V
L
L
K
R
E
I
SDLPL
P
K
G
I
R
D
Y
I
S
F
LYTPPRRPHAHRSGAAPTLCHSRGGPP
T
A
S
A
L
V
L
RQKGSYGDSSASCPPTASPIP
G
S
G
L
R
H
Y
V
R
T
A
D
K
L
M
R
D
S
LMG
N
V
V
LSHNA
P
L
V
DFAYGKMPEPCPRKHSKDRSLSSTPAAPS
L
A
T
VAPTQ
S
S
T
R
R
Q
S
L
E
RSEA
S
T
A
E
A
Y
AENV
E
L
S
ALPLPLN
S
E
K
RRENTNRLVSPGGGDEEG
C
N
E
Q
RDRQGS
D
S
S
L
R
K
E
R
R
STRSSPPPLMSVGDP
I
S
A
T
T
A
A
I
T
S
L
R
T
LTSSKTPVR
S
E
V
R
VDSQAGATDDTGS
C
D
S
A
L
DKSAYSPHQ
N
I
M
FSPLDPMPMALGDH
Q
H
E
M
E
DF
P
V
VAKTGHA
5
PsiBlast_PDB
79.37
27%
-60
- C1 -
-
3MWU
1
?
A:
[23-402]
-----------
R
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
A
S
A
------
K
N
-----
K
D
T
S
T
I
L
R
E
V
E
L
L
K
-
K
L
D
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
R
-------------------------
F
S
E
H
D
A
A
R
I
-
I
K
Q
V
F
S
G
I
T
Y
M
H
K
-
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
ES
K
E
K
D
C
---
D
I
K
-
I
I
D
F
G
L
S
T
C
F
Q
Q
-
N
------
D
R
I
G
T
A
Y
Y
I
A
P
E
V
L
R
-----------
G
T
Y
D
-
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
-
Y
G
K
N
E
-
Y
D
-
I
L
K
R
V
E
T
G
K
Y
----
A
F
----
D
L
P
Q
W
R
T
----
I
S
D
D
A
K
D
----
L
I
R
K
M
L
T
F
H
P
S
L
R
I
-----
T
A
------
T
-
Q
C
L
E
H
P
W
I
------
Q
K
Y
S
S
E
T
P
T
I
SD
L
P
S
L
E
S
A
M
T
N
I
R
Q
F
Q
A
E
K
K
L
A
Q
A
A
L
L
Y
M
A
S
K
L
T
T
L
D
E
T
K
Q
L
T
E
I
F
R
K
L
D
T
N
N
D
G
M
L
-
D
R
D
E
L
V
R
G
Y
H
E
F
M
R
L
K
G
V
D
S
N
S
L
I
Q
N
E
G
S
T
I
E
D
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
78.70
30%
-156
- C1 -
-
5K00
1
MELK_HUMAN
A:
[8-266]
----------
K
Y
Y
E
L
H
E
T
I
G
T
G
--
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
N
T
L
G
------------
S
D
L
P
R
I
K
T
E
I
E
A
L
K
N
L
-
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
--------------------------
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
-
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
--
D
E
Y
-
H
---
K
L
K
-
L
I
D
F
G
L
C
A
K
P
--------------
S
L
A
Y
A
A
P
E
L
I
Q
-----
G
K
----
S
Y
-
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
--
N
-
V
M
A
L
Y
K
K
I
M
R
G
K
Y
----
D
V
----
P
----
K
W
----
L
S
P
S
S
I
L
----
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
------
K
-
N
L
L
N
H
P
W
I
------
M
Q
D
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
77.37
27%
-67
- C1 -
-
3IGO
8
?
A:
[23-395]
-----------
R
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
A
S
A
------
K
N
-----
K
-
T
S
T
I
L
R
E
V
E
L
L
K
-
K
L
D
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
R
-------------------------
F
S
E
H
D
A
A
R
I
-
I
K
Q
V
F
S
G
I
T
Y
M
H
K
-
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
ES
K
E
K
D
C
---
D
I
K
-
I
I
D
F
G
L
S
T
C
F
Q
Q
-
N
-
T
--------
T
A
Y
Y
I
A
P
E
V
L
R
-----------
G
T
Y
D
-
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
-
Y
G
K
N
E
-
Y
D
-
I
L
K
R
V
E
T
G
K
Y
----
A
F
----
D
L
P
Q
W
R
T
----
I
S
D
D
A
K
D
----
L
I
R
K
M
L
T
F
H
P
S
L
R
I
-----
T
A
------
T
-
Q
C
L
E
H
P
W
I
------
Q
K
Y
S
S
E
T
P
T
I
SD
L
P
S
L
E
S
A
M
T
N
I
R
Q
F
Q
A
E
K
K
L
A
Q
A
A
L
L
Y
M
A
S
K
L
T
T
L
D
E
T
K
Q
L
T
E
I
F
R
K
L
D
T
N
N
D
G
M
L
-
D
R
D
E
L
V
R
G
Y
H
E
F
M
R
L
K
G
V
D
S
N
S
L
I
Q
--
G
S
T
I
E
D
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
77.32
29%
-154
- C1 -
-
5ES1
1
MARK4_HUMAN
A:
[14-269]
---------
V
G
N
Y
R
L
L
R
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
R
E
V
A
I
K
I
I
D
K
-
T
Q
L
-----
N
P
-----
S
S
L
Q
K
L
F
R
E
V
R
I
M
K
-
G
L
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
A
G
E
V
F
D
Y
L
-----------
V
S
H
G
R
---------------
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
H
Y
C
H
Q
-
K
N
I
V
H
R
D
L
K
A
E
N
L
L
L
--
D
A
E
-
A
---
N
I
K
-
I
A
D
F
G
F
S
N
----------------
S
P
P
Y
A
A
P
E
L
F
------
Q
G
----
K
K
Y
D
G
P
E
V
D
I
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
--
D
G
H
N
-
L
K
E
L
R
E
R
V
L
R
G
K
Y
----
R
V
----
P
----
F
Y
----
M
S
T
D
C
E
S
----
I
L
R
R
F
L
V
L
N
P
A
K
R
C
-----
T
L
------
E
-
Q
I
M
K
D
K
W
I
------
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
76.75
29%
-135
- C1 -
-
2QNJ
-
MARK3_HUMAN
A:
[55-308]
-----------
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
R
E
V
A
I
K
I
I
D
K
-
T
Q
L
-----
N
P
-----
T
S
L
Q
K
L
F
R
E
V
R
I
M
K
I
L
-
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
I
M
E
Y
A
S
G
G
E
V
F
D
Y
--------------------------
L
V
A
H
G
R
M
K
E
K
E
A
R
S
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
-
K
R
I
V
H
R
D
L
K
A
E
N
L
L
L
--
D
A
D
-
M
---
N
I
K
-
I
A
D
F
G
F
S
N
E
F
T
--------
D
T
F
C
G
S
P
P
Y
A
A
P
E
L
F
------
Q
G
----
K
K
Y
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
Q
--
N
-
L
K
E
L
R
E
R
V
L
R
G
K
Y
----
R
I
----
P
----
F
Y
----
M
S
T
D
C
E
N
----
L
L
K
R
F
L
V
L
N
P
I
K
R
G
-----
T
L
------
E
-
Q
I
M
K
D
R
W
I
------
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
HHSearch
75.89
29%
-154
- C1 -
-
3AQV
1
AAPK2_HUMAN
A:
[11-268]
----------
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
R
-----
S
L
-----
D
V
V
G
K
I
K
R
E
I
Q
N
L
K
L
F
-
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
G
--------------------------
R
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
-
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
--
D
A
H
-
M
---
N
A
K
-
I
A
D
F
G
L
S
N
M
M
S
D
-
G
-
E
-
F
L
------
P
N
Y
A
A
P
E
V
I
S
-----
G
R
----
L
-
Y
A
G
P
E
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
E
H
---
V
P
T
L
F
K
K
I
R
G
G
V
F
----
Y
I
----
P
----
E
Y
----
L
N
R
S
V
A
T
----
L
L
M
H
M
L
Q
V
D
P
L
K
R
A
-----
T
I
------
K
-
D
I
R
E
H
E
W
F
------
K
Q
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
HHSearch
75.45
29%
-108
- C1 -
-
4RA5
3
KPCT_HUMAN
A:
[5-268]
----------
E
D
F
E
L
H
K
M
L
G
K
G
S
F
G
K
V
F
L
A
E
F
K
K
T
N
Q
F
F
A
I
K
A
L
K
K
D
V
V
L
-----
M
D
-----
D
D
V
E
C
T
M
V
E
K
R
V
L
S
L
A
W
E
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
C
H
--------------------------
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
--
D
K
D
-
G
---
H
I
K
-
I
A
D
F
G
M
C
K
E
N
M
L
-
G
D
A
-
K
T
N
E
F
C
G
T
P
D
Y
I
A
P
E
I
L
L
-----
G
Q
----
K
-
Y
-
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
S
P
F
H
G
Q
D
---
E
E
E
L
F
H
S
I
R
M
D
N
P
----
F
Y
----
P
----
R
W
----
L
E
K
E
A
K
D
----
L
L
V
K
L
F
V
R
E
P
E
K
R
L
-----
G
V
------
R
G
D
I
R
Q
H
P
L
F
------
R
E
I
N
W
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
75.09
29%
-134
- C- -
-
3FE3
-
MARK3_HUMAN
A:
[55-308]
-----------
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
R
E
V
A
I
K
I
I
D
K
-
T
Q
L
-----
N
P
-----
T
S
L
Q
K
L
F
R
E
V
R
I
M
K
I
L
-
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
I
M
E
Y
A
S
G
G
E
V
F
D
Y
--------------------------
L
V
A
H
G
R
M
K
E
K
E
A
R
S
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
-
K
R
I
V
H
R
D
L
K
A
E
N
L
L
L
--
D
A
D
-
M
---
N
I
K
-
I
A
D
F
G
F
S
N
E
F
T
V
-
G
-
G
-
K
L
D
A
F
C
G
A
P
P
Y
A
A
P
E
L
F
------
Q
G
----
K
K
Y
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
Q
--
N
-
L
K
E
L
R
E
R
V
L
R
G
K
Y
----
R
I
----
P
----
F
Y
----
M
S
T
D
C
E
N
----
L
L
K
R
F
L
V
L
N
P
I
K
R
G
-----
T
L
------
E
-
Q
I
M
K
D
R
W
I
------
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
HHSearch
74.84
29%
-153
- C1 -
-
3TXO
1
A:
[23-291]
----------
D
N
F
E
F
I
R
V
L
G
K
G
S
F
G
K
V
M
L
A
R
V
K
E
T
G
D
L
Y
A
V
K
V
L
K
K
D
V
I
L
-----
Q
D
-----
D
D
V
E
C
T
M
T
E
K
R
I
L
S
L
A
R
N
H
P
F
L
T
Q
L
F
C
C
F
Q
T
P
D
R
L
F
F
V
M
E
F
V
N
G
G
D
L
M
F
H
I
Q
K
S
R
--------------------------
R
F
D
E
A
R
A
R
F
Y
A
A
E
I
I
S
A
L
M
F
L
H
D
-
K
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
--
D
H
E
-
G
---
H
C
K
-
L
A
D
F
G
M
C
K
E
G
I
C
-----------
G
T
P
D
Y
I
A
P
E
I
L
Q
-----
E
M
-----
L
Y
-
G
P
A
V
D
W
W
A
M
G
V
L
L
Y
E
M
L
C
G
H
A
P
F
E
A
E
N
---
E
D
D
L
F
E
A
I
L
N
D
E
V
----
V
Y
----
P
----
T
W
----
L
H
E
D
A
T
G
----
I
L
K
S
F
M
T
K
N
P
T
M
R
L
-----
G
S
LTQGG
E
H
-
A
I
L
R
H
P
F
F
------
K
E
I
D
W
A
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
73.69
29%
-146
- C1 -
-
5KZ8
1
MARK2_HUMAN
A:
[34-287]
-----------
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
I
D
K
-
T
Q
L
-----
N
S
-----
S
S
L
Q
K
L
F
R
E
V
R
I
M
K
V
L
-
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
--------------------------
L
V
A
H
G
R
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
-
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
--
D
A
D
-
M
---
N
I
K
-
I
A
D
F
G
-----------------
C
G
S
P
P
Y
A
A
P
E
L
F
------
Q
G
----
K
K
Y
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
Q
--
N
-
L
K
E
L
R
E
R
V
L
R
G
K
Y
----
R
I
----
P
----
F
Y
----
M
S
T
D
C
E
N
----
L
L
K
K
F
L
I
L
N
P
S
K
R
G
-----
T
L
------
E
-
Q
I
M
K
D
R
W
M
------
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
73.66
31%
-56
- C1 -
-
4GV1
5
AKT1_HUMAN
A:
[8-280]
----------
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
T
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
-----
A
K
-----
D
E
V
A
H
T
L
T
E
N
R
V
L
Q
N
S
-
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
--------------------------
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
--
D
K
D
-
G
---
H
I
K
-
I
T
D
F
G
L
C
K
E
G
I
K
D
G
-
A
-
T
M
K
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
-----
D
N
----
D
-
Y
-
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
---
H
E
K
L
F
E
L
I
L
M
E
E
I
----
R
F
----
P
----
R
T
----
L
G
P
E
A
K
S
----
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
GGGS
E
D
A
------
K
-
E
I
M
Q
H
R
F
F
------
A
G
I
V
W
Q
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
73.16
29%
-145
- C1 -
-
3IEC
-
MARK2_HUMAN
A:
[8-261]
-----------
N
Y
R
L
L
K
T
I
G
----
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
I
D
K
-
T
Q
L
-----
N
S
-----
S
S
L
Q
K
L
F
R
E
V
R
I
M
K
V
L
-
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
--------------------------
Y
L
V
A
H
G
W
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
-
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
--
D
A
D
-
M
---
N
I
K
-
I
A
D
F
G
F
S
N
E
F
T
F
-
G
-
N
-
K
L
D
T
F
C
G
S
P
P
Y
A
A
P
E
L
F
------
Q
G
----
K
K
Y
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
Q
--
N
-
L
K
E
L
R
E
R
V
L
R
G
K
Y
----
R
I
----
P
----
F
Y
----
M
S
T
D
C
E
N
----
L
L
K
K
F
L
I
L
N
P
S
K
R
G
-----
T
L
------
E
-
Q
I
M
K
D
R
W
M
------
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
71.81
29%
-154
- C1 -
-
5KZ7
1
MARK2_HUMAN
A:
[34-287]
-----------
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
I
D
K
-
T
Q
L
-----
N
S
-----
S
S
L
Q
K
L
F
R
E
V
R
I
M
K
V
L
-
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
--------------------------
L
V
A
H
G
R
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
-
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
--
D
A
D
-
M
---
N
I
K
-
I
A
D
F
-------------------
G
S
P
P
Y
A
A
P
E
L
F
------
Q
G
----
K
--
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
----
N
-
L
K
E
L
R
E
R
V
L
R
G
K
Y
----
R
I
----
P
----
F
Y
----
M
S
T
D
C
E
N
----
L
L
K
K
F
L
I
L
N
P
S
K
R
G
-----
T
L
------
E
-
Q
I
M
K
D
R
W
M
------
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
71.48
34%
-27
- C1 -
-
2Y7J
1
PHKG2_HUMAN
C:
[94-365]
----------
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
V
T
A
E
R
LSPEQ
L
E
-----
E
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
V
--------------------------
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
-
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
--
D
D
N
-
M
---
Q
I
R
-
L
S
D
F
G
F
S
C
H
L
E
P
-
G
-
E
-
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
-----
C
S
MDET
H
P
G
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
R
R
Q
---
I
L
M
L
R
M
I
M
E
G
Q
Y
QFSS
P
E
----
W
----
D
D
----
R
S
S
T
V
K
D
----
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
-----
T
A
------
E
-
Q
A
L
Q
H
P
F
F
------
E
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
71.04
29%
-137
- C1 -
-
5EAK
1
MARK2_HUMAN
A:
[16-269]
-----------
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
I
D
K
-
T
Q
L
-----
N
S
-----
S
S
L
Q
K
L
F
R
E
V
R
I
M
K
V
L
-
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
--------------------------
L
V
A
H
G
R
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
-
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
--
D
A
D
-
M
---
N
I
K
-
I
A
D
F
G
F
S
--------------
F
C
G
S
P
P
Y
A
A
P
E
L
F
------
Q
G
----
K
K
Y
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
Q
--
N
-
L
K
E
L
R
E
R
V
L
R
G
K
Y
----
R
I
----
P
----
F
Y
----
M
S
T
D
C
E
N
----
L
L
K
K
F
L
I
L
N
P
S
K
R
G
-----
T
L
------
E
-
Q
I
M
K
D
R
W
M
------
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
70.89
29%
-146
- C- -
-
2R0I
-
MARK2_RAT
A:
[52-305]
-----------
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
I
D
K
-
T
Q
L
-----
N
S
-----
S
S
L
Q
K
L
F
R
E
V
R
I
M
K
V
L
-
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
--------------------------
L
V
A
H
G
R
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
-
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
--
D
A
D
-
M
---
N
I
K
-
I
A
D
F
-------------------
G
S
P
P
Y
A
A
P
E
L
F
------
Q
G
----
K
K
Y
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
Q
--
N
-
L
K
E
L
R
E
R
V
L
R
G
K
Y
----
R
I
----
P
----
F
Y
----
M
S
T
D
C
E
N
----
L
L
K
K
F
L
I
L
N
P
S
K
R
G
-----
T
L
------
E
-
Q
I
M
K
D
R
W
M
------
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
70.58
29%
-150
- C1 -
-
1ZMU
-
MARK2_RAT
A:
[52-305]
-----------
N
Y
R
L
L
K
T
I
G
K
G
--
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
I
D
K
-
T
Q
L
-----
N
S
-----
S
S
L
Q
K
L
F
R
E
V
R
I
M
K
V
L
-
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
--------------------------
L
V
A
H
G
R
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
-
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
--
D
A
D
-
M
---
N
I
K
-
I
A
---------------------
G
S
P
P
Y
A
A
P
E
L
F
------
Q
G
----
K
K
Y
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
Q
--
N
-
L
K
E
L
R
E
R
V
L
R
G
K
Y
----
R
I
----
P
----
F
Y
----
M
S
T
D
C
E
N
----
L
L
K
K
F
L
I
L
N
P
S
K
R
G
-----
T
L
------
E
-
Q
I
M
K
D
R
W
M
------
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
70.31
32%
-94
- C1 -
-
4NIF
-
KS6A1_HUMAN
A:
[8-270]
----------
D
G
Y
V
V
K
E
T
I
G
V
G
S
Y
S
E
C
K
R
C
V
H
K
A
T
N
M
E
Y
A
V
K
V
I
D
K
S
K
R
-----------------
D
P
S
E
E
I
E
I
L
L
R
Y
G
Q
H
P
N
I
I
T
L
K
D
V
Y
D
D
G
K
H
V
Y
L
V
T
E
L
M
R
G
G
E
L
L
D
K
I
L
R
Q
K
--------------------------
F
F
S
E
R
E
A
S
F
V
L
H
T
I
G
K
T
V
E
Y
L
H
S
-
Q
G
V
V
H
R
D
L
K
P
S
N
I
L
Y
--
V
D
E
S
G
NPE
C
L
R
-
I
C
D
F
G
F
A
K
Q
L
R
A
-
E
-
N
G
L
L
M
T
P
C
Y
---
F
V
A
P
E
V
L
K
-----
R
Q
-----
G
Y
-
D
E
G
C
D
I
W
S
L
G
I
L
L
Y
T
M
L
A
G
Y
T
P
F
A
N
G
P
S
D
T
P
E
E
I
L
T
R
I
G
S
G
K
F
----
T
L
SGGN
W
----
N
T
----
V
S
E
T
A
K
D
----
L
V
S
K
M
L
H
V
D
P
H
Q
R
L
-----
T
A
------
K
-
Q
V
L
Q
H
P
W
V
------
T
Q
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
69.90
30%
-96
- C1 -
-
2WEI
1
?
A:
[23-282]
-----------
R
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
A
S
A
------
K
N
-----
K
D
T
S
T
I
L
R
E
V
E
L
L
K
K
L
-
D
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
R
-------------------------
F
S
E
H
D
A
A
R
I
-
I
K
Q
V
F
S
G
I
T
Y
M
H
K
-
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
--
E
S
K
E
K
D
C
-
D
I
K
-
I
I
D
F
G
L
S
T
C
F
Q
Q
-
N
-
T
-
K
M
K
D
R
I
G
T
A
Y
Y
I
A
P
E
V
L
R
-----
G
------
T
Y
D
-
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
-
G
K
N
E
-
Y
D
-
I
L
K
R
V
E
T
G
K
Y
----
A
F
----
D
----
L
P
QWRT
I
S
D
D
A
K
D
----
L
I
R
K
M
L
T
F
H
P
S
L
R
I
-----
T
A
------
T
-
Q
C
L
E
H
P
W
I
------
Q
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
69.55
29%
-85
- C1 -
-
3HZT
9
?
A:
[5-356]
-----------
R
Y
Q
R
V
K
K
L
G
S
G
A
Y
G
E
V
L
L
C
K
D
K
L
T
G
A
E
R
A
I
K
I
I
K
K
S
S
V
T
-----
T
T
-----
S
N
S
G
A
L
L
D
E
V
A
V
L
K
-
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
R
N
Y
Y
L
V
M
E
V
Y
R
G
G
E
L
F
D
E
I
I
-----
L
R
Q
-
K
F
S
E
V
D
A
A
V
I
M
--------------------
K
Q
V
L
S
G
T
T
Y
L
H
K
-
H
N
I
V
H
R
D
L
K
P
E
N
L
L
L
E-
S
K
S
R
D
---
A
L
I
K
I
V
D
F
G
L
S
A
H
F
E
V
-
G
----------
T
A
Y
Y
I
A
P
E
V
L
R
-----
K
------
K
Y
D
-
E
K
C
D
V
W
S
C
G
V
I
L
Y
I
L
L
-
C
G
Y
P
P
F
G
G
Q
T
D
-
Q
E
-
I
L
K
R
V
E
K
G
K
F
----
S
F
----
D
----
P
P
----
D
W
T
Q
V
S
D
E
A
K
Q
L
V
K
L
M
L
T
Y
E
P
S
K
R
I
-----
S
A
------
E
-
E
A
L
N
H
P
W
I
V
K
F
C
SQ--
V
G
K
H
A
L
T
G
-------
A
L
G
N
M
K
K
F
Q
S
S
Q
K
L
A
Q
A
A
M
--------
L
F
M
G
S
K
L
T
T
L
E
E
T
K
E
L
T
Q
I
F
R
Q
L
D
N
N
G
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
64.85
32%
-27
- C1 -
-
2Y7J
1
PHKG2_HUMAN
A:
[102-363]
------------------
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
V
T
A
E
R
-----
L
S
P
E
Q
L
E
E
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
------
V
A
L
S
E
K
E
T
R
S
I
M
R
S
L
--------------------
L
E
A
V
S
F
L
H
A
-
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
--
D
D
N
-
M
---
Q
I
R
-
L
S
D
F
G
F
S
C
H
L
E
P
-
G
-
E
-
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
C
S
M
D
E
T
H
----
P
G
Y
-
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
R
R
---
Q
I
L
M
L
R
M
I
M
E
G
Q
Y
----
Q
F
----
S
----
S
P
EWDD
R
S
S
T
V
K
D
----
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
-----
T
A
------
E
-
Q
A
L
Q
H
P
F
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------