@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_28_3240: (2018-03-11 )
MEIAADFARRGLRFVGFLGCGAFGDAYVVRDASDTCFVVKRSKSLVKQSGFLEEYLGMMNLCSLNVVTSHDAWIDHESRVCILMDYCDAGDLGDYLKKGYPLPEEEVLSIVAQLLLGLDHIHKRNRVHRDIKPENIFLSSTRAGGGRWPVAKLGDFGSVKRLSRCGARVVSRVGTPLYLAPEIIAGYAYTSKADIWSMGLVVYRLMVNNSPFRVTSVDTHTRCVLRLSPPHPSTLSGYSRALGDCVMAMLSRNWKRRPNAQALLRCDLFQPTLLRHPWIPAPLHVSPCLFVQLRSSLLAVYAAPSERARTLRTLEFGDQVYLSSPRDHSHHGLWLEVLHPFAGFIRNTVKGEPLFDSYASDECMASIGSLTRVLDRAGKQVRRDIS
Atome Classification :
(20 SA)
----------------------------------------------------------------.........10........20........30-.-..-.-.....40-..-..-----.----------...50---..---.......60-........70........80........90.....-..-.-100.......110.......120.-......130.......140.......150.......160....-.-----------------..170.......180...------...-----.190.......200.......210..-.....220......-.230-.-.-.-...-..240.......250.....---..-----.260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
----------------------------------------------------------------ME
I
A
A
D
F
A
RR
G
L
R
F
V
G
F
LGCGAFG
D
A
Y
V
V
R--D-AS-D-
T
C
F
V
V
KR-
S
K
-
S
L
-----
V
----------
K
QSG----
F
L
---
E
E
Y
L
G
M
M
N
L
-C
S
L
N
V
VTSHDAWIDHES
R
V
C
I
L
M
DYCDAG
D
L
G
D
Y
L
-
K
K-G-YPL
P
E
E
E
V
L
S
I
V
A
Q
L
L
L
G
L
D
H
I
H
K
-
R
N
R
VHRDIKPE
N
I
F
L
SSTRAGGGRWPVAKLGD
F
G
S
V
K
R
L
S
R
C
G
-
A
-----------------
R
V
V
S
RVGT
P
L
Y
L
A
P
E
I
IA------GYA-----YTSKA
D
I
W
S
M
G
L
V
V
Y
R
L
MVNNSP
F
R
V
-
T
SVDTH
T
R
C
V
L
R
LS-PP-H-P-
S
-
T
-
L
S
G
-
Y
S
R
A
L
G
D
C
V
M
A
M
L
-SRNWKR---RP-----
N
A
Q
A
L
L
RCDLF
Q
P
T
L
LRHPWIPAPLHVS
P
C
L
F
V
Q
L
R
S
S
L
L
A
VYAAP
S
E
R
A
R
T
L
R
T
LEFG
D
Q
V
Y
LSSPRDHSHH
G
L
W
L
E
V
L
H
P
F
A
G
F
I
R
N
TVKGEPL
F
D
SYA
S
D
E
C
M
A
S
I
G
S
L
T
R
V
L
D
R
A
G
K
Q
V
R
RDIS
48
Fugue
71.91
28%
-13
- C1 -
-
4AW2
5
MRCKA_RAT
A:
[1-416]
S
G
E
V
R
L
R
Q
L
E
Q
F
I
L
D
GPAQTNGQCFS
V
E
T
L
L
D
I
L
I
C
L
Y
D
E
C
N
N
SPLRRE
K
N
I
L
E
Y
L
E
W
A
K
P
F
T
S
K
V
K
Q
M
R
L
H
R
E
D
F
E
I
L
K
V
I
G
R
G
A
F
G
E
V
A
V
V
K
LK
N
-
A
D
-
K
-
V
F
A
M
K
I
L
-
N
K
-
W
E
-----
M
----------
L
K
R
A
ETAC
F
R
---
E
E
R
D
V
L
V
N
G
-
D
S
K
W
I
T
T
L
H
Y
A
F
Q
D
-
D
N
N
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
-
S
K
F
E
-
D
R
L
P
E
E
M
A
R
F
Y
L
A
E
M
V
I
A
I
D
S
V
H
Q
-
L
H
Y
V
H
R
D
I
K
P
D
N
I
L
M
D
M
N
----
G
H
---
I
R
L
A
D
F
G
S
C
L
K
L
M
E
D
G
T
V
-----------------
Q
S
S
V
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
------
A
M
E
GGKGR
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
E
T
P
F
Y
A
E
S
L
V
E
T
Y
G
K
I
M
N
H
K
E
R
F
Q
-
F
-
P
-
T
-
Q
-
V
T
D
-
V
S
E
N
A
K
D
L
I
R
R
L
I
C
S
R
E
H
R
L
---
G
Q
-----
N
G
I
E
D
F
K
---------
K
H
P
F
F
S
G
I
D
W
------------------------
D
N
I
R
N
C
E
A
P
Y
I
P
E
V
S
S
P
T
D
T
S
N
F
D
V
D
S
G
H
H
L
P
F
V
G
F
T
Y
T
S
-------------
S
C
V
L
S
D
R
S
C
L
R
--------------
29
HHSearch
61.61
24%
-14
- C1 -
-
4GV1
5
AKT1_HUMAN
A:
[4-279]
---------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
--
E
-
K
A
T
G
-
R
Y
Y
A
M
K
I
-
L
K
-
K
E
V
I
V
A
K
D
----------
E
V
A
H
----
T
L
---
T
E
N
R
V
L
Q
N
S
-
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
-
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
-
S
R
-
E
-
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
-------
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
-
A
-----------------
T
M
K
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
------
D
N
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
-
Q
D
H
E
K
L
F
E
L
I
L
M
E
E
-
I
R
-----
F
---
P
R
T
-
L
G
P
E
A
K
S
L
L
S
G
L
L
-
K
K
D
P
K
Q
---
R
L
GGGS
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
W
Q
---------------------------------------------------------------------------------------------------------------
33
HHSearch
53.74
25%
-29
- C1 -
-
4XBR
1
INKA1_HUMAN (first)
A:
[93-350]
------------------------------------------------------------------------
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
--
V
-
R
S
S
G
-
K
L
V
A
V
K
K
-
M
D
-
L
R
KQ---
Q
----------
R
R
E
L
----
L
F
---
N
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
-
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
-
T
H
-
T
--
R
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
-
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
-------
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
-
P
-----------------
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
------
R
L
P
-----
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
-
E
P
P
L
K
A
M
K
M
I
R
D
N
L
-
P
P
-
R
-
L
-
K
-
N
-
L
H
K
-
V
S
P
S
L
K
G
F
L
D
R
L
L
-
V
R
D
P
A
Q
---
R
A
-----
T
A
A
E
L
L
K
H
P
F
L
A
K
A
------------------------------------------------------------------------------------------------------------------
34
HHSearch
52.28
25%
-17
- C1 -
-
2Y7J
1
PHKG2_HUMAN
D:
[92-364]
-----------------------------------------------------------------------
F
Y
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
--
H
-
R
A
T
G
-
H
E
F
A
V
K
I
-
M
E
-
V
-------RLSPEQLEE-
V
R
E
A
----
T
R
---
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
-
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
-
T
E
-
K
-
V
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
-
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
D
D
N
M
-------
Q
I
R
L
S
D
F
G
F
S
C
H
L
E
P
G
E
-------------------
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
CSMDET
H
P
G
-----
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
-
R
R
Q
I
L
M
L
R
M
I
M
E
G
Q
-
Y
Q
-
F
-
S
-
S
-
P
E
W
D
D
-
R
S
S
T
V
K
D
L
I
S
R
L
L
-
Q
V
D
P
E
A
---
R
L
-----
T
A
E
Q
A
L
Q
H
P
F
F
E
--------------------------------------------------------------------------------------------------------------------
40
HHSearch
51.20
23%
-48
- C1 -
-
4LQS
1
CBK1_YEAST
A:
[99-454]
----------------------------------------------------------------------
L
S
L
E
D
F
H
T
V
K
V
I
G
K
G
A
F
G
E
V
R
L
V
Q
--
K
-
K
D
T
G
-
K
I
Y
A
M
K
T
-
L
L
-
K
S
EMYKK--------------------------------
S
-
D
S
P
W
V
V
S
L
Y
Y
S
F
Q
D
-
A
Q
Y
L
Y
L
I
M
E
F
L
P
G
G
D
L
M
T
M
L
-
I
R
-
W
-
Q
L
F
T
E
D
V
T
R
F
Y
M
A
E
C
I
L
A
I
E
T
I
H
K
-
L
G
F
I
H
R
A
I
K
P
D
N
I
L
I
D
I
R
G
-------
H
I
K
L
S
D
F
G
L
S
T
G
F
H
K
T
H
-
D
S
N
YNRQQ
I
Q
T
W
R
KSRRL
M
A
Y
S
T
V
G
T
P
D
Y
I
A
P
E
I
F
L
------
Y
Q
G
-----
Y
G
Q
E
C
D
W
W
S
L
G
A
I
M
Y
E
C
L
I
G
W
P
P
F
C
S
-
E
T
P
Q
E
T
Y
R
K
I
M
N
F
E
-
Q
T
-
L
-
Q
-
F
P
D
-
D
I
H
-
I
S
Y
E
A
E
D
L
I
R
R
L
L
-
T
H
A
D
Q
R
LGR
H
G
-----
G
A
D
E
I
K
S
H
P
F
F
R
G
V
D
W
----------------------------------------------------------------------------------------------------------------
32
HHSearch
50.46
25%
-22
- C1 -
-
2Y7J
1
PHKG2_HUMAN
C:
[92-364]
-----------------------------------------------------------------------
F
Y
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
--
H
-
R
A
T
G
-
H
E
F
A
V
K
I
-
M
E
-
V
T
-----
A
ERLSPEQLEE
V
R
E
A
----
T
R
---
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
-
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
-
T
E
-
K
-
V
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
-
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
D
D
N
M
-------
Q
I
R
L
S
D
F
G
F
S
C
H
L
E
P
G
E
-------------------
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
CSMDET
H
P
G
-----
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
-
R
R
Q
I
L
M
L
R
M
I
M
E
G
Q
-
Y
Q
-
F
-
S
-
S
-
P
E
W
D
D
-
R
S
S
T
V
K
D
L
I
S
R
L
L
-
Q
V
D
P
E
A
---
R
L
-----
T
A
E
Q
A
L
Q
H
P
F
F
E
--------------------------------------------------------------------------------------------------------------------
38
HHSearch
49.63
25%
-3
- C1 -
-
4B4L
3
DAPK1_HUMAN
A:
[10-282]
----------------------------------------------------------------------
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
--
E
-
K
S
T
G
-
L
Q
Y
A
A
K
F
-
I
K
-
K
R
-----
R
TKSSRRGV--
S
R
E
D
----
I
E
---
R
E
V
S
I
L
K
E
I
-
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
-
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
-
A
E
-
K
-
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
-
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
---
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
N
-------------------
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
E
P
-----
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
-
D
T
K
Q
E
T
L
A
N
V
S
A
V
N
-
Y
E
-
F
-
E
D
E
-
Y
-
F
S
N
-
T
S
A
L
A
K
D
F
I
R
R
L
L
-
V
K
D
P
K
K
---
R
M
-----
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
D
T
----------------------------------------------------------------------------------------------------------------
30
HHSearch
49.47
25%
-4
- C1 -
-
2X0G
-
DAPK1_HUMAN
A:
[8-280]
----------------------------------------------------------------------
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
--
E
-
K
S
T
G
-
L
Q
Y
A
A
K
F
-
I
K
-
K
R
-----
R
TKSSRRGV--
S
R
E
D
----
I
E
---
R
E
V
S
I
L
K
E
I
-
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
-
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
-
A
E
-
K
-
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
-
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
---
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
N
-------------------
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
E
P
-----
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
-
D
T
K
Q
E
T
L
A
N
V
S
A
V
N
-
Y
E
-
F
-
E
-
D
E
Y
-
F
S
N
-
T
S
A
L
A
K
D
F
I
R
R
L
L
-
V
K
D
P
K
K
---
R
M
-----
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
D
T
----------------------------------------------------------------------------------------------------------------
21
HHSearch
47.90
22%
-32
- C1 -
-
1TKI
-
TITIN_HUMAN
A:
[20-283]
-----------------------------------------------------------------------
L
Y
E
K
Y
M
I
A
E
D
L
G
R
G
E
F
G
I
V
H
R
C
V
--
E
-
T
S
S
K
-
K
T
Y
M
A
K
F
-
V
K
-
V
K
G----
T
----------
D
Q
V
L
----
V
K
---
K
E
I
S
I
L
N
I
A
-
R
H
R
N
I
L
H
L
H
E
S
F
E
S
-
M
E
E
L
V
M
I
F
E
F
I
S
G
L
D
I
F
E
R
I
-
N
T
-
S
A
F
E
L
N
E
R
E
I
V
S
Y
V
H
Q
V
C
E
A
L
Q
F
L
H
S
-
H
N
I
G
H
F
D
I
R
P
E
N
I
I
Y
Q
T
R
R
S
-----
S
T
I
K
I
I
E
F
G
Q
A
R
Q
L
K
P
G
D
-------------------
N
F
R
L
L
F
T
A
P
E
Y
Y
A
P
E
V
H
Q
------
H
D
V
-----
V
S
T
A
T
D
M
W
S
L
G
T
L
V
Y
V
L
L
S
G
I
N
P
F
L
A
-
E
T
N
Q
Q
I
I
E
N
I
M
N
A
E
-
Y
T
-
F
-
D
-
E
-
E
A
F
K
E
-
I
S
I
E
A
M
D
F
V
D
R
L
L
-
V
K
E
R
K
S
---
R
M
-----
T
A
S
E
A
L
Q
H
P
W
L
K
Q
K
I
E
----------------------------------------------------------------------------------------------------------------
43
Fugue
47.40
20%
-26
- C1 -
-
1TKI
-
TITIN_HUMAN
A:
[18-338]
---------------------------------------------------------------------
K
E
L
Y
E
K
Y
M
I
A
E
D
L
G
R
G
E
F
G
I
V
H
R
C
V
--
E
T
S
S
-
K
-
K
T
Y
M
A
K
F
V
K
V
-
K
G
-----
T
----------
D
Q
V
L
----
V
K
---
K
E
I
S
I
L
N
I
A
-
R
H
R
N
I
L
H
L
H
E
S
F
E
S
-
M
E
E
L
V
M
I
F
E
F
I
S
G
L
D
I
F
E
R
I
N
T
S
-
A
-
F
E
L
N
E
R
E
I
V
S
Y
V
H
Q
V
C
E
A
L
Q
F
L
H
S
-
H
N
I
G
H
F
D
I
R
P
E
N
I
I
Y
Q
T
R
R
S
-----
S
T
I
K
I
I
E
F
G
Q
A
R
Q
L
K
P
-
G
-
D
-----------------
N
F
R
L
L
F
T
A
P
E
Y
Y
A
P
E
V
H
Q
------
H
D
V
-----
V
S
T
A
T
D
M
W
S
L
G
T
L
V
Y
V
L
L
S
G
I
N
P
F
L
A
-
E
T
N
Q
Q
I
I
E
N
I
M
N
A
E
-
Y
T
-
F
D
E
-
E
-
A
-
F
K
E
-
I
S
I
E
A
M
D
F
V
D
R
L
L
-
V
K
E
R
K
S
---
R
M
-----
T
A
S
E
A
L
Q
----------
H
P
W
L
K
Q
K
-----------------
I
E
R
V
S
T
K
V
I
R
T
L
K
H
R
R
Y
Y
H
T
L
I
K
K
D
L
N
--------------
M
V
V
S
A
A
R
I
S
C
G
G
A
I
R
S
Q
K
G
V
S
V
A
K
V
K
V
A
S
I
----------------
2
PsiBlast_PDB
47.03
31%
-2
- C1 -
-
4O27
1
STK24_HUMAN
B:
[14-254]
---------------------------------------------------------------------------------
I
G
K
G
S
F
G
E
V
F
K
G
I
--
D
-
N
R
-
T
-
Q
K
V
V
A
I
K
-
I
I
-
D
L
-----
E
----------
E
A
E
D
----
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
-
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
-
E
P
-
G
--
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
-
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
-------
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
-
I
-----------------
K
R
N
E
F
V
G
T
P
F
W
M
A
P
E
V
I
K
------
Q
S
A
-----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
-----
E
L
H
P
M
K
V
L
F
L
I
-
P
K
N
N
-
P
-
P
-
T
-
L
E
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
-
N
K
E
P
S
F
---
R
P
-----
T
A
K
E
L
L
K
-------------------------------------------------------------------------------------------------------------------------
41
HHSearch
45.73
25%
-11
- C1 -
-
1KOB
1
?
A:
[49-313]
-----------------------------------------------------------------------
V
Y
D
Y
Y
D
I
L
E
E
L
G
S
G
A
F
G
V
V
H
R
C
V
--
E
-
K
A
T
G
-
R
V
F
V
A
K
F
-
I
N
-
T
P
Y
P
---
L
----------
D
K
Y
T
----
V
K
---
N
E
I
S
I
M
N
Q
L
-
H
H
P
K
L
I
N
L
H
D
A
F
E
D
-
K
Y
E
M
V
L
I
L
E
F
L
S
G
G
E
L
F
D
R
I
-
A
A
-
E
D
Y
K
M
S
E
A
E
V
I
N
Y
M
R
Q
A
C
E
G
L
K
H
M
H
E
-
H
S
I
V
H
L
D
I
K
P
E
N
I
M
C
E
T
K
K
A
-----
S
S
V
K
I
I
D
F
G
L
A
T
K
L
N
P
D
E
-------------------
I
V
K
V
T
T
A
T
A
E
F
A
A
P
E
I
V
D
------
R
E
P
-----
V
G
F
Y
T
D
M
W
A
I
G
V
L
G
Y
V
L
L
S
G
L
S
P
F
A
G
-
E
D
D
L
E
T
L
Q
N
V
K
R
C
D
-
W
E
-
F
-
D
-
E
D
A
-
F
S
S
-
V
S
P
E
A
K
D
F
I
K
N
L
L
-
Q
K
E
P
R
K
---
R
L
-----
T
V
H
D
A
L
E
H
P
W
L
K
G
D
H
S
----------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
45.65
31%
8
- C1 -
-
4QMV
3
STK24_HUMAN
A:
[37-277]
---------------------------------------------------------------------------------
I
G
K
G
S
F
G
E
V
F
K
G
I
--
D
-
N
R
-
T
-
Q
K
V
V
A
I
K
-
I
I
-
D
L
-----
E
----------
E
A
E
D
----
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
-
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
-
E
P
-
G
--
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
-
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
-------
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
-
I
-----------------
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
------
Q
S
A
-----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
-----
E
L
H
P
M
K
V
L
F
L
I
-
P
K
N
N
-
P
-
P
-
T
-
L
E
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
-
N
K
E
P
S
F
---
R
P
-----
T
A
K
E
L
L
K
-------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
45.55
31%
5
- C1 -
-
4QML
2
STK24_HUMAN
A:
[37-277]
---------------------------------------------------------------------------------
I
G
K
G
S
F
G
E
V
F
K
G
I
--
D
-
N
R
-
T
-
Q
K
V
V
A
I
K
-
I
I
-
D
L
-----
E
----------
E
A
E
D
----
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
-
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
-
E
P
-
G
--
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
-
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
-------
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
-
I
-----------------
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
------
Q
S
A
-----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
-----
E
L
H
P
M
K
V
L
F
L
I
-
P
K
N
N
-
P
-
P
-
T
-
L
E
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
-
N
K
E
P
S
F
---
R
P
-----
T
A
K
E
L
L
K
-------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
45.38
31%
6
- C1 -
-
4QMT
2
STK24_HUMAN
A:
[37-277]
---------------------------------------------------------------------------------
I
G
K
G
S
F
G
E
V
F
K
G
I
--
D
-
N
R
-
T
-
Q
K
V
V
A
I
K
-
I
I
-
D
L
-----
E
----------
E
A
E
D
----
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
-
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
-
E
P
-
G
--
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
-
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
-------
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
-
I
-----------------
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
------
Q
S
A
-----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
-----
E
L
H
P
M
K
V
L
F
L
I
-
P
K
N
N
-
P
-
P
-
T
-
L
E
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
-
N
K
E
P
S
F
---
R
P
-----
T
A
K
E
L
L
K
-------------------------------------------------------------------------------------------------------------------------
36
HHSearch
45.08
24%
-4
- C1 -
-
2BDW
-
KCC2D_CAEEL
A:
[8-275]
----------------------------------------------------------------------
K
F
S
D
N
Y
D
V
K
E
E
L
G
K
G
A
F
S
V
V
R
R
C
V
--
H
-
K
T
T
G
-
L
E
F
A
A
K
I
-
I
N
-
T
K
KLS
A
-
R
----------
D
F
Q
K
----
L
E
---
R
E
A
R
I
C
R
K
L
-
Q
H
P
N
I
V
R
L
H
D
S
I
Q
E
-
E
S
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
-
V
A
-
R
-
E
F
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
I
A
Y
C
H
S
-
N
G
I
V
H
R
N
L
K
P
E
N
L
L
L
A
S
K
A
K
----
G
A
A
V
K
L
A
D
F
G
L
A
I
E
V
N
D
S
E
-------------------
A
W
H
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
K
------
K
D
P
-----
Y
S
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
-
E
D
Q
H
R
L
Y
A
Q
I
K
A
G
A
-
Y
D
-
Y
-
P
-
S
-
P
E
W
D
T
-
V
T
P
E
A
K
S
L
I
D
S
M
L
-
T
V
N
P
K
K
---
R
I
-----
T
A
D
Q
A
L
K
V
P
W
I
C
N
R
E
-----------------------------------------------------------------------------------------------------------------
44
Fugue
44.88
21%
-0
- C1 -
-
1KOB
1
?
A:
[23-374]
---------------------------------------------INDYDKFYEDIWKK
Y
V
P
Q
P
V
E
V
K
Q
G
S
V
Y
D
Y
Y
D
I
L
E
E
L
G
S
G
A
F
G
V
V
H
R
C
V
--
E
-
K
A
-
T
G
R
V
F
V
A
K
F
-
I
N
T
P
Y
-----
P
----------
L
D
K
Y
----
T
V
---
K
N
E
I
S
I
M
N
Q
-
L
H
H
P
K
L
I
N
L
H
D
A
F
E
D
K
Y
E
M
V
L
I
L
E
F
L
S
G
G
E
L
F
D
R
I
A
A
E
-
D
-
Y
K
M
S
E
A
E
V
I
N
Y
M
R
Q
A
C
E
G
L
K
H
M
H
E
-
H
S
I
V
H
L
D
I
K
P
E
N
I
M
C
E
T
K
K
A
S
S
-----
V
K
I
I
D
F
G
L
A
T
K
L
N
P
-
D
-
E
-----------------
I
V
K
V
T
T
A
T
A
E
F
A
A
P
E
I
V
D
------
R
E
P
-----
V
G
F
Y
T
D
M
W
A
I
G
V
L
G
Y
V
L
L
S
G
L
S
P
F
A
G
-
E
D
D
L
E
T
L
Q
N
V
K
R
C
D
-
W
E
-
F
-
D
-
E
D
A
-
F
S
S
-
V
S
P
E
A
K
D
F
I
K
N
L
L
-
Q
K
E
P
R
K
---
R
L
-----
T
V
H
D
A
L
E
----------
H
P
W
L
K
G
D
-------------------
H
S
N
L
T
S
R
I
P
S
S
R
Y
N
K
I
R
Q
K
I
K
E
K
Y
A
D
W
P
A
P
Q
P
A
I
G
R
I
A
N
F
S
S
L
R
K
H
R
P
Q
E
Y
Q
I
Y
D
S
Y
F
D
R
K
E
A
----------------------
11
PsiBlast_PDB
44.19
31%
6
- C1 -
-
4QMU
1
STK24_HUMAN
A:
[37-277]
---------------------------------------------------------------------------------
I
G
K
G
S
F
G
E
V
F
K
G
I
--
D
-
N
R
-
T
-
Q
K
V
V
A
I
K
-
I
I
-
D
L
-----
E
----------
E
A
E
D
----
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
-
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
-
E
P
-
G
--
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
-
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
-------
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
-
I
-----------------
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
------
Q
S
A
-----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
-----
E
L
H
P
M
K
V
L
F
L
I
-
P
K
N
N
-
P
-
P
-
T
-
L
E
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
-
N
K
E
P
S
F
---
R
P
-----
T
A
K
E
L
L
K
-------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
44.17
31%
6
- C1 -
-
4QMO
3
STK24_HUMAN
A:
[37-277]
---------------------------------------------------------------------------------
I
G
K
G
S
F
G
E
V
F
K
G
I
--
D
-
N
R
-
T
-
Q
K
V
V
A
I
K
-
I
I
-
D
L
-----
E
----------
E
A
E
D
----
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
-
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
-
E
P
-
G
--
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
-
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
-------
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
-
I
-----------------
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
------
Q
S
A
-----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
-----
E
L
H
P
M
K
V
L
F
L
I
-
P
K
N
N
-
P
-
P
-
T
-
L
E
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
-
N
K
E
P
S
F
---
R
P
-----
T
A
K
E
L
L
K
-------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
43.51
31%
5
- C1 -
-
4QMP
2
STK24_HUMAN
A:
[37-277]
---------------------------------------------------------------------------------
I
G
K
G
S
F
G
E
V
F
K
G
I
--
D
-
N
R
-
T
-
Q
K
V
V
A
I
K
-
I
I
-
D
L
-----
E
----------
E
A
E
D
----
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
-
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
-
E
P
-
G
--
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
-
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
-------
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
-
I
-----------------
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
------
Q
S
A
-----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
-----
E
L
H
P
M
K
V
L
F
L
I
-
P
K
N
N
-
P
-
P
-
T
-
L
E
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
-
N
K
E
P
S
F
---
R
P
-----
T
A
K
E
L
L
K
-------------------------------------------------------------------------------------------------------------------------