@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_29_2140: (2018-03-11 )
MAQAAYPPSREGSYPHSRSGGPRANPMLPEQMIGSYVIRETIGRGSFGKVKKGRHVHTGEYVAIKILNRQKLKSANMDKKIHREIEILQLFSHPNICRLYEVISTPTDMYLIMEYVEGGELYDYIVQKGRVRESEARYIFQQIVCAIEYCHHFRVVHRDLKPENILLGTGLQVKLIDFGLSNITKDGEFLATSCGSPNYAAPEVISGKLYFGPEVDVWSCGVILYALLCGCLPFDEDSIPLLFSKIKKGKYAIPSNMQTGPRELIQQILVVDPLVRLTVPQIRDNAWFNQRLPMRLSYSESIFSVKEDRILSVLVSETAKRLGVRDRDVRKELELGYGAAFVAYNILLDARRRREIAAEVRELGMSGDESRGVSHVIGAQQTKFQPKATERELNMGLMLTQSPAMVVLLDEEDATRNKWAYNRGCFVPASVATLGDPTKVSDTSLSDGSGNGGPGGSIAVGSFRITSKMCSGSLVGSGSVGSSSYAPGSLRGAAGLTGGSSSYRRAGMQSSTGGTAASQLGANLSDQPRVGSVARKHAMYTAEEEQFIVENNYGWRIGIMTDWRAEQALSAIYDVLRTFKMQWKVVSPFRLLARSTAETWSVMADSTQSRNASTRRNTLSTYSVESSAPIRIGCRSGAPGSGSSDDHEDGDIAGSMQRDEECIHAHITRTRRAGAAARSFGSAPGGGFNTSSSQVARGNYFGGLQGGDEEAAIVSGSAASGVLQSAHAIESGSESTSSPRDPRGASPPASAAASTSAIAEPASSPANPVVISLYFFRIHERHDKGYLVDFKVVRNAMVAADLVLLLSDTLVRKLG
Atome Classification :
(23 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120......-.130.......140.......150.......160.....--..170.......180.......190.......200.......210.......220.......230.......240.......250.----......260.......270.......280.......290....-----...300------------.......310.......320.......330....--...340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810...
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MAQAAYPPSREGSYPHSRSGGPRANPML
P
E
Q
M
I
G
S
Y
V
I
R
E
T
IGRGSFGKVKKG
R
H
VHTG
E
Y
V
A
I
K
I
L
N
R
Q
K
LKSANM
D
K
K
I
H
R
E
I
E
I
L
Q
L
FSHP
N
I
C
R
L
Y
E
V
ISTPT
D
M
Y
L
I
M
E
Y
VEGG
E
L
Y
D
Y
I
V
QK-GRVR
E
S
E
A
R
Y
I
F
Q
Q
I
V
C
A
I
E
Y
C
H
H
F
R
V
V
H
RDLKPE
N
I
L
L--GTG
L
Q
V
K
L
I
DF
G
L
S
NITKDG
E
F
L
A
TSCGSPNYAAPEVISG
K
L
Y
FGPEV
D
V
W
S
C
G
V
I
L
Y
A
L
L
C
GCLPFDEDS
I
P
L
L
F
S
K
IKKG
K
Y
AI----PSNMQT
G
P
R
E
L
I
Q
Q
I
L
V
VD
P
L
V
R
LTVPQIRDNAWFNQRL
P
M
R
L
-----SYS
E
S
I
------------
F
SV
K
E
D
R
I
L
S
V
L
V
S
E
T
A
K
RLGVR
D
R
D
V
R
K
E
L
E
LG--Y
G
A
A
F
V
A
Y
N
I
L
L
D
A
R
R
R
R
E
I
A
A
E
V
R
E
LGMSGDESRG
V
S
H
V
IGAQQTKFQPKATERELNM
G
L
M
L
TQSP
A
M
V
V
L
LDEEDATRNKWAYNRGCFVPA
S
V
ATLGDPTKVSDTSLSDGSGNGGPGG
S
I
A
V
G
S
F
R
I
T
S
KMCS
G
S
L
VGSGSVGSSSYAPGSLRGAAGLTGGS
S
S
Y
R
RAGMQSSTGG
T
A
A
S
Q
LGANLSDQPR
V
G
S
V
A
R
K
H
AMYTAEE
E
Q
F
I
V
ENNY
G
W
R
I
G
I
M
TD
W
R
A
E
Q
A
L
S
A
I
Y
D
V
L
R
T
F
K
M
Q
W
K
VV
S
P
F
R
L
L
A
R
STAE
T
W
S
V
MADSTQSRNASTRR
N
T
L
S
T
YSVESSA
P
I
R
I
G
CRSGAPGSGSSDDHEDGDIAGSMQR
D
E
E
C
I
H
A
H
I
T
R
T
RRAGAAARSFGSAPGGGFNTSSSQVARGNYFGGLQGGDE
E
A
A
I
VSGS
A
A
S
G
V
L
Q
S
A
H
AIESGSESTSSPRDPRGASPPASAAASTSAIAEPASSPAN
P
V
V
I
S
L
Y
F
F
R
IHERHDK
G
Y
L
V
D
F
K
V
V
R
N
A
M
V
A
A
D
L
V
L
L
L
S
D
T
L
V
R
KLG
2
PsiBlast_PDB
93.02
52%
-139
- C1 -
-
5EZV
2
AAPK1_HUMAN (first)
A:
[27-449]
--------------------------------
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
R
S
L
D
V
V
G
K
I
K
R
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
-
G
R
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
--
D
A
H
M
N
A
K
I
A
D
F
G
L
S
N
M
M
S
D
G
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
G
P
E
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
E
H
V
P
T
L
F
K
K
I
R
G
G
V
F
Y
I
----
P
E
Y
L
N
R
S
V
A
T
L
L
M
H
M
L
Q
V
D
P
L
K
R
A
T
I
K
D
I
R
E
H
E
W
F
K
Q
D
L
P
S
Y
L
-----
F
P
E
D
P
--------------
S
Y
D
A
N
V
I
D
D
E
A
V
K
E
V
C
E
K
F
E
C
T
E
S
E
V
M
N
S
L
Y
S
G
DP
Q
D
Q
L
A
V
A
Y
H
L
I
I
D
N
R
R
I
M
N
Q
A
S
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
92.30
53%
-137
- C1 -
-
5ISO
2
?
A:
[13-429]
--------------------------------
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
R
S
L
D
V
V
G
K
I
K
R
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
-
G
R
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
--
D
A
H
M
N
A
K
I
A
D
F
G
L
S
N
M
M
S
D
G
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
G
P
E
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
E
H
V
P
T
L
F
K
K
I
R
G
G
V
F
Y
I
----
P
E
Y
L
N
R
S
V
A
T
L
L
M
H
M
L
Q
V
D
P
L
K
R
A
T
I
K
D
I
R
E
H
E
W
F
K
Q
D
L
P
S
Y
L
-----
F
P
E
D
P
--------------
S
Y
D
A
N
V
I
D
D
E
A
V
K
E
V
C
E
K
F
E
C
T
E
S
E
V
M
N
S
L
Y
S
G
DP
Q
D
Q
L
A
V
A
Y
H
L
I
I
D
N
R
R
I
M
N
Q
A
S
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
83.55
50%
-141
- C1 -
-
4RED
-
AAPK1_HUMAN
B:
[13-341]
------------------------------
V
K
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
A
V
A
V
K
I
L
N
R
Q
K
I
R
S
L
D
V
V
G
K
I
R
R
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
-
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
--
D
A
H
M
N
A
K
I
A
D
F
G
L
S
N
M
M
S
D
--------
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
D
H
V
P
T
L
F
K
K
I
C
D
G
I
F
Y
T
----
P
Q
Y
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
S
I
K
D
I
R
E
H
E
W
F
K
Q
D
L
P
K
Y
L
-----
F
P
E
D
P
S
--------------
Y
S
T
T
M
I
D
D
E
A
L
K
E
V
C
E
K
F
E
C
S
E
E
E
V
L
S
C
L
Y
N
R
NH
Q
D
P
L
A
V
A
Y
H
L
I
I
D
N
R
R
I
M
N
E
A
K
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
82.99
60%
-150
- C1 -
-
2YZA
-
AAPK2_HUMAN
A:
[13-276]
--------------------------------
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
R
S
L
D
V
V
G
K
I
K
R
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
-
G
R
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
--
D
A
H
M
N
A
K
I
A
D
F
G
L
S
N
M
M
S
D
-----------
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
G
P
E
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
E
H
V
P
T
L
F
K
K
I
R
G
G
V
F
Y
I
----
P
E
Y
L
N
R
S
V
A
T
L
L
M
H
M
L
Q
V
D
P
L
K
R
A
T
I
K
D
I
R
E
H
E
W
F
K
Q
D
L
P
S
Y
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
82.96
60%
-141
- C1 -
-
3AQV
1
AAPK2_HUMAN
A:
[10-273]
--------------------------------
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
R
S
L
D
V
V
G
K
I
K
R
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
-
G
R
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
--
D
A
H
M
N
A
K
I
A
D
F
G
L
S
N
M
M
S
D
G
E
F
L
------
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
G
P
E
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
E
H
V
P
T
L
F
K
K
I
R
G
G
V
F
Y
I
----
P
E
Y
L
N
R
S
V
A
T
L
L
M
H
M
L
Q
V
D
P
L
K
R
A
T
I
K
D
I
R
E
H
E
W
F
K
Q
D
L
P
S
Y
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
82.65
60%
-140
- C1 -
-
3AQV
1
AAPK2_HUMAN
A:
[7-273]
-----------------------------
R
V
K
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
R
S
L
D
V
V
G
K
I
K
R
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
-
G
R
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
--
D
A
H
M
N
A
K
I
A
D
F
G
L
S
N
M
M
S
D
G
E
F
L
------
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
G
P
E
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
E
H
V
P
T
L
F
K
K
I
R
G
G
V
F
Y
I
----
P
E
Y
L
N
R
S
V
A
T
L
L
M
H
M
L
Q
V
D
P
L
K
R
A
T
I
K
D
I
R
E
H
E
W
F
K
Q
D
L
P
S
Y
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
77.36
42%
-116
- C1 -
-
2QNJ
-
MARK3_HUMAN
B:
[48-367]
---------------------------
D
E
Q
P
H
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
R
E
V
A
I
K
I
I
D
K
T
Q
L
N
-
P
T
S
L
Q
K
L
F
R
E
V
R
I
M
K
I
L
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
I
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
-
G
R
M
K
E
K
E
A
R
S
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
R
I
V
H
R
D
L
K
A
E
N
L
L
L
--
D
A
D
M
N
I
K
I
A
D
F
G
F
S
N
E
F
T
---
K
L
D
T
F
C
G
S
P
P
Y
A
A
P
E
L
F
Q
G
K
K
Y
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
Q
N
L
K
E
L
R
E
R
V
L
R
G
K
Y
R
I
----
P
F
Y
M
S
T
D
C
E
N
L
L
K
R
F
L
V
L
N
P
I
K
R
G
T
L
E
Q
I
M
K
D
R
W
I
N
A
G
H
E
E
D
E
-----
L
K
P
F
--------------
V
E
P
E
L
D
I
S
D
Q
K
-
R
I
D
I
M
V
G
M
G
Y
S
Q
E
E
I
Q
E
S
L
S
K
M
K-
Y
D
E
I
T
A
T
Y
L
L
L
G
R
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
76.65
50%
-134
- C1 -
-
4RED
-
AAPK1_HUMAN
A:
[13-341]
------------------------------
V
K
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
A
V
A
V
K
I
L
N
R
Q
K
I
R
S
L
D
V
V
G
K
I
R
R
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
-
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
--
D
A
H
M
N
A
K
I
A
D
F
G
L
S
N
M
M
S
D
---------
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
D
H
V
P
T
L
F
K
K
----
I
F
Y
T
----
P
Q
Y
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
S
I
K
D
I
R
E
H
E
W
F
K
Q
D
L
P
K
Y
L
-----
F
P
E
D
P
S
--------------
Y
S
T
T
M
I
D
D
E
A
L
K
E
V
C
E
K
F
E
C
S
E
E
E
V
L
S
C
L
Y
N
R
NH
Q
D
P
L
A
V
A
Y
H
L
I
I
D
N
R
R
I
M
N
E
A
K
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
76.25
55%
-152
- C1 -
-
3DAE
-
SNF1_YEAST
A:
[52-314]
--------------------------------
I
G
N
Y
Q
I
V
K
T
L
G
E
G
S
F
G
K
V
K
L
A
Y
H
T
T
T
G
Q
K
V
A
L
K
I
I
N
K
K
V
L
A
----
Q
G
R
I
E
R
E
I
S
Y
L
R
L
L
R
H
P
H
I
I
K
L
Y
D
V
I
K
S
K
D
E
I
I
M
V
I
E
Y
A
-
G
N
E
L
F
D
Y
I
V
Q
R
-
D
K
M
S
E
Q
E
A
R
R
F
F
Q
Q
I
I
S
A
V
E
Y
C
H
R
H
K
I
V
H
R
D
L
K
P
E
N
L
L
L
--
D
E
H
L
N
V
K
I
A
D
F
----------------
G
S
P
N
Y
A
A
P
E
V
I
S
G
K
L
Y
A
G
P
E
V
D
V
W
S
C
G
V
I
L
Y
V
M
L
C
R
R
L
P
F
D
D
E
S
I
P
V
L
F
K
N
I
S
N
G
V
Y
T
L
----
P
K
F
L
S
P
G
A
A
G
L
I
K
R
M
L
I
V
N
P
L
N
R
I
S
I
H
E
I
M
Q
D
D
W
F
K
V
D
L
P
E
Y
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
76.23
48%
-127
- C1 -
-
4RER
2
AAPK1_HUMAN
A:
[5-401]
--------------------------------
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
R
S
L
D
V
V
G
K
I
R
R
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
-
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
--
D
A
H
M
N
A
K
I
A
D
F
G
L
S
N
M
M
S
D
G
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
D
H
V
P
T
L
F
K
K
I
C
D
G
I
F
Y
T
----
P
Q
Y
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
S
I
K
D
I
R
E
H
E
W
F
K
Q
D
L
P
K
Y
L
FPEDP
S
Y
S
---DDEALKEVCEK-
F
E
C
S
E
E
E
V
L
S
C
L
Y
N
R
N
H
Q
-------------------
D
P
L
A
V
A
Y
H
L
I
I
D
N
R
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
74.23
39%
-132
- C1 -
-
5K00
1
MELK_HUMAN
A:
[5-326]
------------------------------
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
--
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
N
T
L
G
--
S
D
L
P
R
I
K
T
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
-
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
--
D
E
Y
H
K
L
K
L
I
D
F
G
L
C
A
K
P
-----------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
S
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
K
Y
D
V
----
P
K
W
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
L
L
N
H
P
W
I
M
Q
D
Y
N
Y
P
V
-----
E
W
Q
S
K
N
---------------
P
F
I
H
L
D
D
D
C
V
T
E
L
S
V
H
H
R
N
N
R
Q
T
M
E
D
L
I
S
L
W
Q-
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
73.99
42%
-113
- C- -
-
3FE3
-
MARK3_HUMAN
B:
[50-366]
-----------------------------
Q
P
H
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
R
E
V
A
I
K
I
I
D
K
T
Q
L
-
N
P
T
S
L
Q
K
L
F
R
E
V
R
I
M
K
I
L
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
I
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
-
G
R
M
K
E
K
E
A
R
S
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
R
I
V
H
R
D
L
K
A
E
N
L
L
L
--
D
A
D
M
N
I
K
I
A
D
F
G
F
S
N
E
F
T
V
G
G
K
L
D
A
F
C
G
A
P
P
Y
A
A
P
E
L
F
Q
G
K
K
Y
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
Q
N
L
K
E
L
R
E
R
V
L
R
G
K
Y
R
I
----
P
F
Y
M
S
T
D
C
E
N
L
L
K
R
F
L
V
L
N
P
I
K
R
G
T
L
E
Q
I
M
K
D
R
W
I
N
A
G
H
E
E
D
E
-----
L
K
P
F
--------------
V
E
P
E
L
D
I
S
D
Q
K
-
R
I
D
I
M
V
G
M
G
Y
S
Q
E
E
I
Q
E
S
L
S
K
M
K-
Y
D
E
I
T
A
T
Y
L
L
L
G
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
73.09
55%
-157
- C1 -
-
3HYH
-
SNF1_YEAST
A:
[54-314]
----------------------------------
N
Y
Q
I
V
K
T
L
G
E
G
---
K
V
K
L
A
Y
H
T
T
T
G
Q
K
V
A
L
K
I
I
N
K
K
------
M
Q
G
R
I
E
R
E
I
S
Y
L
R
L
L
R
H
P
H
I
I
K
L
Y
D
V
I
K
S
K
D
E
I
I
M
V
I
E
Y
A
-
G
N
E
L
F
D
Y
I
V
Q
R
-
D
K
M
S
E
Q
E
A
R
R
F
F
Q
Q
I
I
S
A
V
E
Y
C
H
R
H
K
I
V
H
R
D
L
K
P
E
N
L
L
L
--
D
E
H
L
N
V
K
I
A
D
F
G
L
S
---------------
P
N
Y
A
A
P
E
V
I
S
G
K
L
Y
A
G
P
E
V
D
V
W
S
C
G
V
I
L
Y
V
M
L
C
R
R
L
P
F
D
D
E
S
I
P
V
L
F
K
N
I
S
N
G
V
Y
T
L
----
P
K
F
L
S
P
G
A
A
G
L
I
K
R
M
L
I
V
N
P
L
N
R
I
S
I
H
E
I
M
Q
D
D
W
F
K
V
D
L
P
E
Y
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
72.48
49%
-131
- C1 -
-
4RED
-
AAPK1_HUMAN
A:
[15-334]
--------------------------------
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
A
V
A
V
K
I
L
N
R
Q
K
I
R
S
L
D
V
V
G
K
I
R
R
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
-
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
--
D
A
H
M
N
A
K
I
A
D
F
G
L
S
N
M
M
S
D
---------
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
D
H
V
P
T
L
F
K
K
----
I
F
Y
T
----
P
Q
Y
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
S
I
K
D
I
R
E
H
E
W
F
K
Q
D
L
P
K
Y
L
FPEDP
S
Y
S
T
T
M
ID
D
E
A
L
K
E
V
C
E
K
F
E
C
S
E
E
E
V
L
S
C
L
Y
N
R
N
H
Q
-------------------
D
P
L
A
V
A
Y
H
L
I
I
D
N
R
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
71.72
54%
-158
- C1 -
-
3HYH
-
SNF1_YEAST
A:
[54-312]
----------------------------------
N
Y
Q
I
V
K
T
L
G
E
---
G
K
V
K
L
A
Y
H
T
T
T
G
Q
K
V
A
L
K
I
I
N
K
K
------
M
Q
G
R
I
E
R
E
I
S
Y
L
R
L
L
R
H
P
H
I
I
K
L
Y
D
V
I
K
S
K
D
E
I
I
M
V
I
E
Y
A
G
N
-
E
L
F
D
Y
I
V
Q
R
-
D
K
M
S
E
Q
E
A
R
R
F
F
Q
Q
I
I
S
A
V
E
Y
C
H
R
H
K
I
V
H
R
D
L
K
P
E
N
L
L
L
--
D
E
H
L
N
V
K
I
A
D
F
G
L
S
---------------
P
N
Y
A
A
P
E
V
I
S
G
K
L
Y
A
G
P
E
V
D
V
W
S
C
G
V
I
L
Y
V
M
L
C
R
R
L
P
F
D
D
E
S
I
P
V
L
F
K
N
I
S
N
G
V
Y
T
L
----
P
K
F
L
S
P
G
A
A
G
L
I
K
R
M
L
I
V
N
P
L
N
R
I
S
I
H
E
I
M
Q
D
D
W
F
K
V
D
L
P
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
71.23
50%
-129
- C1 -
-
2QNJ
-
MARK3_HUMAN
A:
[53-308]
--------------------------------
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
R
E
V
A
I
K
I
I
D
K
T
Q
L
N
P
T
S
L
-
Q
K
L
F
R
E
V
R
I
M
K
I
L
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
I
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
-
G
R
M
K
E
K
E
A
R
S
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
R
I
V
H
R
D
L
K
A
E
N
L
L
L
--
D
A
D
M
N
I
K
I
A
D
F
G
F
S
N
E
F
T
-----
D
T
F
C
G
S
P
P
Y
A
A
P
E
L
F
Q
G
K
K
Y
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
Q
N
L
K
E
L
R
E
R
V
L
R
G
K
Y
R
I
----
P
F
Y
M
S
T
D
C
E
N
L
L
K
R
F
L
V
L
N
P
I
K
R
G
T
L
E
Q
I
M
K
D
R
W
I
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
68.50
49%
-142
- C1 -
-
5KZ8
1
MARK2_HUMAN
A:
[32-287]
--------------------------------
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
I
D
K
T
Q
L
N
S
S
S
L
-
Q
K
L
F
R
E
V
R
I
M
K
V
L
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
-
G
R
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
--
D
A
D
M
N
I
K
I
A
D
F
G
--------------
C
G
S
P
P
Y
A
A
P
E
L
F
Q
G
K
K
Y
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
Q
N
L
K
E
L
R
E
R
V
L
R
G
K
Y
R
I
----
P
F
Y
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
R
G
T
L
E
Q
I
M
K
D
R
W
M
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
67.73
48%
-151
- C1 -
-
1ZMV
-
MARK2_RAT
A:
[51-305]
---------------------------------
G
N
Y
R
L
L
K
T
I
G
K
G
--
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
R
I
I
D
K
T
Q
L
N
S
S
S
L
-
Q
K
L
F
R
E
V
R
I
M
K
V
L
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
-
G
R
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
--
D
A
D
M
N
I
K
I
A
------------------
G
S
P
P
Y
A
A
P
E
L
F
Q
G
K
K
Y
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
Q
N
L
K
E
L
R
E
R
V
L
R
G
K
Y
R
I
----
P
F
Y
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
R
G
T
L
E
Q
I
M
K
D
R
W
M
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
66.43
49%
-124
- C- -
-
3FE3
-
MARK3_HUMAN
A:
[53-308]
--------------------------------
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
R
E
V
A
I
K
I
I
D
K
T
Q
L
N
P
T
S
L
-
Q
K
L
F
R
E
V
R
I
M
K
I
L
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
I
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
-
G
R
M
K
E
K
E
A
R
S
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
R
I
V
H
R
D
L
K
A
E
N
L
L
L
--
D
A
D
M
N
I
K
I
A
D
F
G
F
S
N
E
F
T
V
G
G
K
L
D
A
F
C
G
A
P
P
Y
A
A
P
E
L
F
Q
G
K
K
Y
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
Q
N
L
K
E
L
R
E
R
V
L
R
G
K
Y
R
I
----
P
F
Y
M
S
T
D
C
E
N
L
L
K
R
F
L
V
L
N
P
I
K
R
G
T
L
E
Q
I
M
K
D
R
W
I
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
66.26
49%
-143
- C- -
-
2R0I
-
MARK2_RAT
A:
[50-305]
--------------------------------
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
I
D
K
T
Q
L
N
S
S
S
L
-
Q
K
L
F
R
E
V
R
I
M
K
V
L
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
-
G
R
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
--
D
A
D
M
N
I
K
I
A
D
F
----------------
G
S
P
P
Y
A
A
P
E
L
F
Q
G
K
K
Y
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
Q
N
L
K
E
L
R
E
R
V
L
R
G
K
Y
R
I
----
P
F
Y
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
R
G
T
L
E
Q
I
M
K
D
R
W
M
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
66.05
49%
-150
- C1 -
-
5KZ7
1
MARK2_HUMAN
A:
[32-287]
--------------------------------
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
I
D
K
T
Q
L
N
S
S
S
L
-
Q
K
L
F
R
E
V
R
I
M
K
V
L
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
-
G
R
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
--
D
A
D
M
N
I
K
I
A
D
F
----------------
G
S
P
P
Y
A
A
P
E
L
F
Q
G
K
--
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
--
N
L
K
E
L
R
E
R
V
L
R
G
K
Y
R
I
----
P
F
Y
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
R
G
T
L
E
Q
I
M
K
D
R
W
M
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
64.50
49%
-129
- C1 -
-
5EAK
1
MARK2_HUMAN
A:
[14-269]
--------------------------------
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
I
D
K
T
Q
L
N
S
S
S
L
-
Q
K
L
F
R
E
V
R
I
M
K
V
L
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
-
G
R
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
--
D
A
D
M
N
I
K
I
A
D
F
G
F
S
-----------
F
C
G
S
P
P
Y
A
A
P
E
L
F
Q
G
K
K
Y
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
Q
N
L
K
E
L
R
E
R
V
L
R
G
K
Y
R
I
----
P
F
Y
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
R
G
T
L
E
Q
I
M
K
D
R
W
M
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
45.11
31%
-59
- C1 -
-
2X4F
4
MYLK4_HUMAN
A:
[89-350]
---------------------------------
Y
T
V
S
K
T
E
I
L
G
-----
Q
V
H
K
C
E
E
T
A
T
G
L
K
L
A
A
K
I
I
K
T
R
G
M
---
K
D
K
E
E
V
K
N
E
I
S
V
M
N
Q
L
D
H
A
N
L
I
Q
L
Y
D
A
F
E
S
K
N
D
I
V
L
V
M
E
Y
V
D
G
G
E
L
F
D
R
I
I
D
E
S
Y
N
L
T
E
L
D
T
I
L
F
M
K
Q
I
C
E
G
I
R
H
M
H
Q
M
Y
I
L
H
L
D
L
K
P
E
N
I
L
C
VN
R
D
A
K
Q
I
K
I
I
D
F
G
L
A
R
R
Y
K
P
R
E
K
L
K
V
N
F
G
T
P
E
F
L
A
P
E
V
V
N
Y
D
F
-
V
S
F
P
T
D
M
W
S
V
G
V
I
A
Y
M
L
L
S
G
L
S
P
F
L
G
D
N
D
A
E
T
L
N
N
I
L
A
C
R
W
D
L
EDEE
F
Q
D
I
S
E
E
A
K
E
F
I
S
K
L
L
I
K
E
K
S
W
R
I
S
A
S
E
A
L
K
H
P
W
L
S
D
H
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------