@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_29_2260: (2018-03-11 )
MLRMNRNQEDSIQPESNKDVMVHARAQSVTKSVQHRPSPHENDVDGAADAPPRRAAGARSRSPPLPSAQQRGCTRVESTSCTYTLREEIGRGEYGRVFLADATPHQLQPQLPLQHSQSASFLPSPTSGVVVGLGSKGRSEPRNAGGRPSRMVLKRMDNTSVEDGLQAATLREIMVLDEVSAGTSNRDRVERDAFRRGRAVFRPATAAPSNTHVQEGFPSSFVDHNRYCSGGAAEDEWDDAALSSSGPLRIGALDALSAQQRRRISRGRQHLIGIRDAILRPREQLAYVVMDYCEGGDLWHFMRDLKVSVRSSSGKFGDIMSTRVFRRWSVELILALGFLHSHNIAHRDLKPQNLMLAKRTDAILSSSFAVDSANGSELCDIEGAPAGELYTLKVGDFGLSRLEGIPYKKYVHEAVTLWYRSPDVLLGNTNYTYSADAWSLGCILVEMASGTVLFKGKDEADELRHIFTRGCRPSPSIFPRMRDYHYCERYAEVLNRYQEADTENMTSEELMQMQLERISRHLRAFLRDRHALELLGDAGVDLVARLLILDPERRLTVLEAMNHRFFTNAYAEVYGADG
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160------.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280---........290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400......----.410.......420.....-----..430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MLRMNRNQEDSIQPESNK
D
V
M
V
H
A
R
A
Q
S
V
T
K
S
V
QHRPSPHENDVDGAADAPPRRAAGARSRSPPL
P
S
A
Q
QRGCTRVESTS
C
T
Y
T
L
R
E
EIGRGEYG
R
V
F
LADATPHQLQPQLPLQHSQSASFLPSPTS
G
V
V
V
GLGSKGRSEPRNAGGR
P
S
R
M
V
L
K
RMDNT
S
V
E
------
D
G
L
Q
A
A
T
L
R
E
I
M
V
L
D
EVSAGTS
N
R
D
R
V
E
R
D
A
F
RRGR
A
V
FRPATAAPSNTHVQEGF
P
S
SFVDHNRYCSGGAAEDEWDDAALSSSG
P
L
R
I
G
A
L
D
A
L
S
A
Q
Q
R
R
R
I
S
RG
R
Q
H
L
I
G
I
R
D
A
I
LR
P
----
R
E
Q
L
A
Y
V
V
M
D
YCEGG
D
L
W
H
F
M
R
D
L
K
V
S
V
RSSSGK
F
G
D
I
M
S
T
R
V
F
R
R
W
S
V
E
L
I
L
A
L
G
F
L
HSHNIAHRDLKPQN
L
M
L
A
K
R
T
D
A
I
LSS
S
F
A
VDSANGS
E
L
CDIEGAPAG
E
L
Y
T
L
K
VGDF
G
L
S
R
LEGI
P
Y
K
----
K
Y
V
H
E
A
V
T
L
WYRSP
D
V
L
L
G-----NT
N
Y
T
Y
SADAW
S
L
G
C
I
L
V
EMAS
G
T
V
L
F
KGKD
E
A
D
E
L
R
H
I
F
TRGCRPSP
S
I
F
P
RM
R
D
Y
H
Y
C
E
R
Y
A
E
V
L
N
R
Y
Q
EADTENM
T
S
E
E
L
M
Q
M
Q
L
E
R
I
S
R
H
L
R
A
F
L
R
D
R
H
A
L
E
L
L
GDA
G
V
D
L
V
A
R
L
L
ILDP
E
R
R
L
T
V
L
E
A
MN
H
R
F
F
T
N
A
Y
A
E
VYGADG
43
HHSearch
93.12
33%
-139
- C1 -
-
3GC0
1
?
A:
[32-326]
------------------------------------------------------------------------------
S
I
D
R
Y
R
R
I
T
K
L
G
E
G
T
Y
G
E
V
Y
K
A
I
D
------------------------------------------
T
V
T
N
E
T
V
A
I
K
R
I
R
L
E
H
-------------
T
A
I
R
E
V
S
L
L
K
E
L
Q
---------------------------------------------------------------------------------------
H
R
N
I
I
E
L
K
S
V
I
H
H
------
N
H
R
L
H
L
I
F
E
Y
A
E
N
-
D
L
K
K
Y
M
D
K
N
P
------------
D
V
S
M
R
V
I
K
S
F
L
Y
Q
L
I
N
G
V
N
F
C
H
S
R
R
C
L
H
R
D
L
K
P
Q
N
L
L
L
S
V
-----------------------------
E
T
P
V
L
K
I
G
D
F
G
L
A
R
A
F
-------------
E
I
I
T
L
W
Y
R
P
P
E
I
L
L
G
-----
S
R
H
Y
S
T
S
V
D
I
W
S
I
A
C
I
W
A
E
M
L
M
K
T
P
L
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P
G
D
S
E
I
D
Q
L
F
K
I
F
E
V
L
G
L
P
D
D
T
T
W
P
G
V
T
A
L
P
D
---
W
---
K
Q
S
F
P
K
--------------
F
R
G
K
T
---
L
K
R
V
-----
L
G
A
L
L
D
D
E
G
L
D
L
L
T
A
M
L
E
M
D
P
V
K
R
I
S
A
K
N
A
L
E
H
P
Y
F
S
H
N
D
--------
35
HHSearch
87.54
30%
-125
- C1 -
-
1UA2
1
CDK7_HUMAN
D:
[13-299]
-----------------------------------------------------------------------------------
E
K
L
D
F
L
G
E
G
Q
F
A
T
V
Y
K
A
R
D
------------------------------------------
K
N
T
N
Q
I
V
A
I
K
K
I
---------------
N
R
T
A
L
R
E
I
K
L
L
Q
E
L
S
---------------------------------------------------------------------------------------
H
P
N
I
I
G
L
L
D
A
F
G
H
------
K
S
N
I
S
L
V
F
D
F
M
E
T
-
D
L
E
V
I
I
K
D
N
S
-----------
L
V
L
T
P
S
H
I
K
A
Y
M
L
M
T
L
Q
G
L
E
Y
L
H
Q
H
W
I
L
H
R
D
L
K
P
N
N
L
L
L
D
E
------------------------------
N
G
V
L
K
L
A
D
F
G
L
A
K
S
F
G
S
P
N
R
----
A
Y
T
H
Q
V
V
T
R
W
Y
R
A
P
E
L
L
F
G
-----
A
R
M
Y
G
V
G
V
D
M
W
A
V
G
C
I
L
A
E
L
L
L
R
V
P
F
L
P
G
D
S
D
L
D
Q
L
T
R
I
F
E
T
L
G
T
P
T
E
E
Q
W
P
D
M
C
S
L
P
D
Y
V
T
F
----
K
S
F
------------------
P
G
I
--
P
L
H
H
I
------
F
S
A
A
G
D
D
L
L
D
L
I
Q
G
L
F
L
F
N
P
C
A
R
I
T
A
T
Q
A
L
K
M
K
Y
F
S
N
R
P
--------
42
HHSearch
78.66
24%
-130
- C1 -
-
2BDW
-
KCC2D_CAEEL
A:
[6-275]
----------------------------------------------------------------------------
T
K
F
S
D
N
Y
D
V
K
E
E
L
G
K
G
A
F
S
V
V
R
R
C
V
H
------------------------------------------
K
T
T
G
L
E
F
A
A
K
I
I
N
T
K
K
L
S
------
A
R
D
F
Q
K
L
E
R
E
A
R
I
C
R
K
L
Q
---------------------------------------------------------------------------------------
H
P
N
I
V
R
L
H
D
S
I
Q
E
------
E
S
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
------------
F
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
I
A
Y
C
H
S
N
G
I
V
H
R
N
L
K
P
E
N
L
L
L
A
S
K
A
---------------------------
K
G
A
A
V
K
L
A
D
F
G
L
A
I
E
V
N
D
S
E
-----
A
W
H
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
K
K
-----
D
-
P
Y
S
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
H
R
L
Y
A
Q
I
K
A
G
A
Y
D
------------------------
Y
P
--------------------
S
----------
P
E
W
D
T
V
T
P
E
A
K
S
L
I
D
S
M
L
T
V
N
P
K
K
R
I
T
A
D
Q
A
L
K
V
P
W
I
C
N
R
E
--------
37
HHSearch
76.47
28%
-31
- C1 -
-
5BYZ
7
MK07_HUMAN
A:
[4-305]
------------------------------------------------------------------------------
V
G
D
E
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
------------------------------------------
R
L
T
G
Q
Q
V
A
I
K
K
I
P
N
A
F
D
V
------
V
T
N
A
K
R
T
L
R
E
L
K
I
L
K
H
F
K
---------------------------------------------------------------------------------------
H
D
N
I
I
A
I
K
D
I
L
R
P
T
VPYG
E
F
K
S
V
Y
V
V
L
D
L
M
E
S
-
D
L
H
Q
I
I
H
S
S
------------
Q
P
L
T
L
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
E
------------------------------
N
C
E
L
K
I
G
D
F
G
M
A
R
G
L
C
T
S
P
A
EHQY
F
M
T
E
Y
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
-----
L
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
R
R
Q
L
F
P
G
K
N
Y
V
H
Q
L
Q
L
I
M
M
V
L
G
T
P
S
P
A
V
I
Q
A
V
G
A
----
E
R
V
R
A
Y
I
Q
S
L
P
-----------------
P
R
Q
P
V
P
W
E
T
------
V
Y
P
G
A
D
R
Q
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
Y
H
D
-------
41
HHSearch
71.97
22%
-135
- C1 -
-
1KOB
1
?
A:
[50-312]
-------------------------------------------------------------------------------
Y
D
Y
Y
D
I
L
E
E
L
G
S
G
A
F
G
V
V
H
R
C
V
E
------------------------------------------
K
A
T
G
R
V
F
V
A
K
F
I
N
T
P
Y
P
L
--------
D
K
Y
T
V
K
N
E
I
S
I
M
N
Q
L
H
---------------------------------------------------------------------------------------
H
P
K
L
I
N
L
H
D
A
F
E
D
------
K
Y
E
M
V
L
I
L
E
F
L
S
G
G
E
L
F
D
R
I
A
A
E
D
-----------
Y
K
M
S
E
A
E
V
I
N
Y
M
R
Q
A
C
E
G
L
K
H
M
H
E
H
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I
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H
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E
N
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M
C
E
T
K
K
----------------------------
A
S
S
V
K
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F
G
L
A
T
K
L
N
P
D
E
-----
I
V
K
V
T
T
A
T
A
E
F
A
A
P
E
I
V
D
R
-----
E
-
P
V
G
F
Y
T
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M
W
A
I
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Y
V
L
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F
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G
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D
D
L
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T
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Q
N
V
K
R
C
D
W
E
F
--------------------------------------------
D
E
D
----------
A
F
S
S
V
S
P
E
A
K
D
F
I
K
N
L
L
Q
K
E
P
R
K
R
L
T
V
H
D
A
L
E
H
P
W
L
K
G
D
H
--------
23
HHSearch
71.32
23%
-137
- C1 -
-
2X4F
4
MYLK4_HUMAN
A:
[89-349]
--------------------------------------------------------------------------------
Y
T
V
S
K
T
E
I
L
G
-----
Q
V
H
K
C
E
E
------------------------------------------
T
A
T
G
L
K
L
A
A
K
I
I
K
T
R
G
M
K
--------
D
K
E
E
V
K
N
E
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V
M
N
Q
L
D
---------------------------------------------------------------------------------------
H
A
N
L
I
Q
L
Y
D
A
F
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S
------
K
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V
L
V
M
E
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V
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C
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N
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D
----------------------------
A
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Y
K
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R
E
-----
K
L
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V
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F
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T
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A
P
E
V
V
N
Y
-----
D
-
F
V
S
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A
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L
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C
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L
-------------------------------------------
E
-
D
----------
E
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R
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H
P
W
L
S
D
H
---------
17
PsiBlast_PDB
71.26
28%
-131
- C1 -
-
1GIJ
1
CDK2_HUMAN
A:
[82-293]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
V
H
Q
D
L
K
-
T
F
M
D
A
S
A
L
T
G
--
I
P
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P
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L
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Q
L
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G
L
A
F
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S
H
R
V
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D
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K
P
Q
N
L
L
I
-----------------------
N
T
E
G
A
-------
I
K
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A
D
F
G
L
A
------------------
V
T
L
W
Y
R
A
P
E
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G
-----
C
K
Y
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W
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G
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---
M
P
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V
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P
P
--------------------------
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
-----
16
PsiBlast_PDB
70.74
28%
-130
- C1 -
-
1GII
1
CDK2_HUMAN
A:
[82-293]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
V
H
Q
D
L
K
-
T
F
M
D
A
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-----------------------
N
T
E
G
A
-------
I
K
L
A
D
F
G
L
A
R
A
F
---------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
-----
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
---
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
D
F
S
K
V
V
P
P
--------------------------
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
-----
18
PsiBlast_PDB
69.73
28%
-131
- C1 -
-
2DS1
-
CDK2_HUMAN
A:
[82-293]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
V
H
Q
D
L
K
-
T
F
M
D
A
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-----------------------
N
T
E
G
A
-------
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-----
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
---
M
P
D
Y
K
P
S
F
P
K
W
A
R
Q
D
F
S
K
V
V
P
P
--------------------------
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
-----
30
HHSearch
69.61
28%
-33
- C1 -
-
2Y7J
1
PHKG2_HUMAN
D:
[91-365]
-----------------------------------------------------------------------------
E
F
Y
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
------------------------------------------
R
A
T
G
H
E
F
A
V
K
I
M
E
V
---
R
LSPEQL
E
E
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
A
--------------------------------------------------------------------------------------
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
------
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
V
------------
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
D
D
------------------------------
N
M
Q
I
R
L
S
D
F
G
F
S
C
H
L
E
P
G
-
E
----
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
C
SMDET
H
P
G
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
R
R
Q
I
L
M
L
R
M
I
M
E
G
Q
Y
Q
F
----------------------------------------
S
---
S
P
-----------
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
A
E
Q
A
L
Q
H
P
F
F
E
R
----------
22
HHSearch
69.60
24%
0
- C- -
-
2WEL
7
KCC2D_HUMAN
A:
[2-271]
------------------------------------------------------------------------------
M
T
D
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
------------------------------------------
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
K
L
S
------
A
R
D
H
Q
K
L
E
R
E
A
R
I
C
R
L
L
K
---------------------------------------------------------------------------------------
H
P
N
I
V
R
L
H
D
S
I
S
E
------
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
------------
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
---------------------------
K
G
A
A
V
K
L
A
D
F
G
L
A
I
E
V
Q
G
D
Q
Q
----
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
-----
D
-
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
H
R
L
Y
Q
Q
I
K
A
G
A
Y
------------------------
D
F
P
--------------------
S
P
----------
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
C
Q
R
---------
1
PsiBlast_PDB
69.49
31%
-124
- C1 -
-
1V0O
1
CDC2H_PLAFK
A:
[81-284]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
D
L
K
K
L
L
D
V
C
E
G
G
L
E
S
V
T
A
----
K
S
F
L
L
Q
L
L
N
G
I
A
Y
C
H
D
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
R
E
---------------------------
G
E
---
L
K
I
A
D
F
G
L
A
R
A
F
G
I
P
V
R
----
K
Y
T
H
E
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
-----
S
K
K
Y
S
T
T
I
D
I
W
S
V
G
C
I
F
A
E
M
V
N
G
T
P
L
F
P
G
V
S
E
A
D
Q
L
M
R
I
F
R
I
L
G
T
P
N
S
K
N
W
P
N
V
T
E
----------
L
P
K
Y
D
----
P
N
F
T
V
Y
E
P
L
P
W
E
---------
S
F
L
K
G
------
L
D
E
S
G
I
D
L
L
S
K
M
L
K
L
D
P
N
Q
R
I
T
A
K
Q
A
L
E
H
A
Y
F
------------
21
HHSearch
69.47
22%
-133
- C1 -
-
1TKI
-
TITIN_HUMAN
A:
[20-284]
------------------------------------------------------------------------------
L
Y
E
K
Y
M
I
A
E
D
L
G
R
G
E
F
G
I
V
H
R
C
V
E
------------------------------------------
T
S
S
K
K
T
Y
M
A
K
F
V
K
V
K
G
T
---------
D
Q
V
L
V
K
K
E
I
S
I
L
N
I
A
R
---------------------------------------------------------------------------------------
H
R
N
I
L
H
L
H
E
S
F
E
S
------
M
E
E
L
V
M
I
F
E
F
I
S
G
L
D
I
F
E
R
I
N
T
S
A
-----------
F
E
L
N
E
R
E
I
V
S
Y
V
H
Q
V
C
E
A
L
Q
F
L
H
S
H
N
I
G
H
F
D
I
R
P
E
N
I
I
Y
Q
T
R
R
----------------------------
S
S
T
I
K
I
I
E
F
G
Q
A
R
Q
L
K
P
G
-
D
----
N
F
R
L
L
F
T
A
P
E
Y
Y
A
P
E
V
H
Q
H
-----
D
-
V
V
S
T
A
T
D
M
W
S
L
G
T
L
V
Y
V
L
L
S
G
I
N
P
F
L
A
E
T
N
Q
Q
I
I
E
N
I
M
N
A
E
Y
T
F
---------------------------------------------
D
E
---------
E
A
F
K
E
I
S
I
E
A
M
D
F
V
D
R
L
L
V
K
E
R
K
S
R
M
T
A
S
E
A
L
Q
H
P
W
L
K
Q
K
I
E
R
------
3
PsiBlast_PDB
68.96
31%
-129
- C1 -
-
1V0P
1
CDC2H_PLAFK
A:
[81-284]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
D
L
K
K
L
L
D
V
C
E
G
G
L
E
S
V
T
A
----
K
S
F
L
L
Q
L
L
N
G
I
A
Y
C
H
D
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
R
E
---------------------------
G
E
---
L
K
I
A
D
F
G
L
A
R
A
F
G
-------------
I
V
T
L
W
Y
R
A
P
D
V
L
M
G
-----
S
K
K
Y
S
T
T
I
D
I
W
S
V
G
C
I
F
A
E
M
V
N
G
T
P
L
F
P
G
V
S
E
A
D
Q
L
M
R
I
F
R
I
L
G
T
P
N
S
K
N
W
P
N
V
T
E
----------
L
P
K
Y
D
----
P
N
F
T
V
Y
E
P
L
P
W
E
---------
S
F
L
K
G
------
L
D
E
S
G
I
D
L
L
S
K
M
L
K
L
D
P
N
Q
R
I
T
A
K
Q
A
L
E
H
A
Y
F
------------
14
PsiBlast_PDB
67.54
29%
-134
- C1 -
-
4YC3
1
CDK1_HUMAN
A:
[102-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
Y
M
D
S
S
L
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
-----------------------
L
I
D
D
K
G
-------
T
I
K
L
A
D
F
G
L
A
R
A
F
G
I
P
I
R
----
V
Y
T
---
V
T
L
W
Y
R
S
P
E
V
L
L
G
-----
S
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
T
K
K
P
L
F
H
G
D
S
E
I
D
Q
L
F
R
I
F
R
A
L
G
T
P
N
N
E
V
W
P
E
V
E
S
---
L
Q
D
Y
K
N
T
F
P
K
W
K
P
G
S
----------------
L
A
S
H
V
K
N
----------
L
D
E
N
G
L
D
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
N
D
----------
13
PsiBlast_PDB
67.28
29%
-134
- C1 -
-
5LQF
1
CDK1_HUMAN
A:
[102-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
Y
M
D
S
S
L
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
-----------------------
L
I
D
D
K
G
-------
T
I
K
L
A
D
F
G
L
A
R
A
F
G
I
P
I
R
---------
V
V
T
L
W
Y
R
S
P
E
V
L
L
G
-----
S
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
T
K
K
P
L
F
H
G
D
S
E
I
D
Q
L
F
R
I
F
R
A
L
G
T
P
N
N
E
V
W
P
E
V
E
S
---
L
Q
D
Y
K
N
T
F
P
K
W
K
P
G
S
----------------
L
A
S
H
V
K
N
----------
L
D
E
N
G
L
D
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
N
D
----------
25
HHSearch
67.08
28%
-30
- C1 -
-
2Y7J
1
PHKG2_HUMAN
C:
[91-365]
-----------------------------------------------------------------------------
E
F
Y
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
------------------------------------------
R
A
T
G
H
E
F
A
V
K
I
M
E
V
T
A
E
R
LSPEQL
E
E
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
A
--------------------------------------------------------------------------------------
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
------
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
V
------------
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
D
D
------------------------------
N
M
Q
I
R
L
S
D
F
G
F
S
C
H
L
E
P
G
-
E
----
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
C
SMDET
H
P
G
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
R
R
Q
I
L
M
L
R
M
I
M
E
G
Q
Y
Q
F
----------------------------------------
S
---
S
P
-----------
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
A
E
Q
A
L
Q
H
P
F
F
E
R
----------
27
HHSearch
66.68
26%
-48
* C1 *
-
1J1B
1
GSK3B_HUMAN
B:
[48-345]
--------------------------------------------------------------------------
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
------------------------------------------
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
K
------------
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
---------------------------------------------------------------------------------------
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
GEKK
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
---------
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
-----------------------------
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
-----
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
-----
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
------------
N
Y
T
E
F
--------
K
F
P
Q
I
K
A
H
P
W
T
----
K
V
F
-----
R
P
R
T
P
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
-------
26
HHSearch
66.46
25%
-47
- C1 -
-
3C0I
1
CSKP_HUMAN
A:
[21-295]
-----------------------------------------------------------------------------
L
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
------------------------------------------
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
SP---
G
L
S
T
E
D
L
K
R
E
A
S
I
C
H
M
L
K
---------------------------------------------------------------------------------------
H
P
H
I
V
E
L
L
E
T
Y
S
S
------
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
A
--------
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
E
---------------------------
N
S
A
P
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
S
G
L
----
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
R
-----
E
-
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
K
E
R
-
L
F
E
G
I
I
K
G
K
Y
K
M
--------------------------------------------
N
P
R
----------
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
R
-------
7
PsiBlast_PDB
66.36
32%
-127
- C1 -
-
2PK9
1
PHO85_YEAST
A:
[105-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
L
N
L
V
K
Y
F
Q
W
Q
L
L
Q
G
L
A
F
C
H
E
N
K
I
L
H
R
D
L
K
P
Q
N
L
L
I
N
K
R
G
Q
------------------------------
L
K
L
G
D
F
G
L
A
R
A
F
G
I
P
V
N
----
T
F
S
S
E
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
-----
S
R
T
Y
S
T
S
I
D
I
W
S
C
G
C
I
L
A
E
M
I
T
G
K
P
L
F
P
G
T
N
D
E
E
Q
L
K
L
I
F
D
I
M
G
T
P
N
E
S
L
W
P
S
V
T
K
----------
L
P
K
Y
N
P
------------
N
I
Q
-
Q
R
P
P
R
D
L
R
Q
V
L
Q
P
-
H
T
K
E
P
L
D
G
N
L
M
D
F
L
H
G
L
L
Q
L
N
P
D
M
R
L
S
A
K
Q
A
L
H
H
P
W
F
A
E
Y
Y
--------