@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_29_2430: (2018-03-11 )
MKNRPALALDAAVVEKFQQDSKSYQINSNNSLQFRAFLFNEAGMYTKDGRELPSTVKKDDIDYSSKRNVGAGASGDVFFARLKNGTSIALKRIPISSKAHRDEVDRELQVFMARGDSPYVMNNYGAFWDAEDDAIVIPMEWMPYTVKDLGLFWGGLNEALLKAVFFQVVSGLVYLHDVKRVLHRDLKPSNLLISETGHVKIADFGVSRLIQTLAVSSTYVGTMCFMAPERLEQGMYGFSSDVWSLGLTMIGAVTGKNPWAPPEEMNLYQLLGKMANGSTPTLPKSGAFSDDVKDFVKQCLERDPDTRPTCAELLQHRFFDGVTTESAVAMVKMAVEQMTRLINNNAQKEKEVTRSQESLEKDVKAQLDKMVL
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80..-......90.......-.100.......110.......120.......130.......140.......150...-....160.......170.......180.......190.......200.....-..210.......220.......230.......240.......250.......260.----------.-------------.....270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MKNRPALAL
D
A
A
V
V
E
K
F
Q
QDSK
S
Y
Q
INSNN
S
L
Q
F
R
A
F
L
FNEAGMYTKDGRELPSTVKKDDIDYSSKRNVGAGASG
D
V
F
F
A
RLK-NG
T
S
I
A
L
K
RIPISSK-A
H
R
D
E
V
D
R
E
L
Q
V
F
MARGDS
P
Y
V
MNNYGAFWDAED
D
A
I
V
I
PMEWMP
Y
T
V
K
D
L
G
L
F
WG
G
-
L
N
E
A
L
L
K
A
V
F
F
Q
V
V
S
G
L
V
Y
L
H
D
V
K
R
V
L
H
RDLKPS
N
L
L
ISETG
H
V
K
I
A
D
F
G
V
S
-
R
L
I
Q
T
L
AVSSTY
V
G
T
M
C
FM
A
P
E
R
L
E
Q
G
MYGFS
S
D
V
W
S
L
G
L
T
M
I
GAVTGKNPWA
P
P
E
----------E-------------M
N
L
Y
Q
L
L
G
K
MANGSTPTLPKSGAF
S
D
D
V
K
D
F
V
K
Q
C
L
ERDPDTR
P
T
C
A
E
L
L
Q
H
RFFDGVT
T
E
S
A
V
A
M
V
K
M
A
V
E
Q
M
T
R
L
INNN
A
Q
K
E
K
E
V
T
R
S
Q
E
S
L
E
K
D
V
K
A
Q
L
D
K
MVL
8
PsiBlast_PDB
90.45
38%
-20
- C1 -
-
4ANB
2
MP2K1_HUMAN
A:
[7-262]
---------------------------------------------------------
K
D
D
-
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
K
K
A
G
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
E
M
A
--
N
E
F
V
G
T
R
S
Y
M
S
P
E
R
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
R
P
P
--------------------------
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
-
S
A
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
-----------------------------------------------------
5
PsiBlast_PDB
89.32
38%
-22
- C1 -
-
4AN2
2
MP2K1_HUMAN
A:
[7-262]
---------------------------------------------------------
K
D
D
-
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
K
K
A
G
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
E
M
A
--
N
E
F
V
G
T
R
S
Y
M
S
P
E
R
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
R
P
P
--------------------------
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
-
S
A
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
-----------------------------------------------------
7
PsiBlast_PDB
88.25
38%
-17
- C1 -
-
4AN9
2
MP2K1_HUMAN
A:
[7-262]
---------------------------------------------------------
K
D
D
-
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
K
K
A
G
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
E
M
A
--
N
E
-
V
G
T
R
S
Y
M
S
P
E
R
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
R
P
P
--------------------------
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
-
S
A
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
-----------------------------------------------------
14
PsiBlast_PDB
88.05
34%
-15
- C1 -
-
3EQD
1
MP2K1_HUMAN
A:
[31-328]
---------------------------------------------------------
K
D
D
-
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
K
K
A
G
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
--
N
S
F
V
G
T
R
S
Y
M
S
P
E
R
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
GC
P
-------------
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
-
S
G
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
-----------------------------------------------------
18
PsiBlast_PDB
87.81
34%
-12
- C1 -
-
3EQI
1
MP2K1_HUMAN
A:
[31-328]
---------------------------------------------------------
K
D
D
-
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
K
K
A
G
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
--
N
S
F
V
G
T
R
S
Y
M
S
P
E
R
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
FGC
P
-------------
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
-
S
G
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
-----------------------------------------------------
6
PsiBlast_PDB
87.71
38%
-15
- C1 -
-
4AN3
2
MP2K1_HUMAN
A:
[7-262]
---------------------------------------------------------
K
D
D
-
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
K
K
A
G
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
E
M
A
--
N
E
--
G
T
R
S
Y
M
S
P
E
R
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
R
P
P
--------------------------
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
-
S
A
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
-----------------------------------------------------
13
PsiBlast_PDB
86.75
34%
-14
- C1 -
-
3EQC
2
MP2K1_HUMAN
A:
[31-328]
---------------------------------------------------------
K
D
D
-
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
K
K
A
G
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
-----
V
G
T
R
S
Y
M
S
P
E
R
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
GC
P
-------------
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
-
S
G
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
-----------------------------------------------------
17
PsiBlast_PDB
86.42
34%
-15
- C1 -
-
3EQH
2
MP2K1_HUMAN
A:
[31-328]
---------------------------------------------------------
K
D
D
-
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
K
K
A
G
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
--
N
S
F
V
G
T
R
S
Y
M
S
P
E
R
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
GC
P
-------------
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
-
S
G
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
-----------------------------------------------------
16
PsiBlast_PDB
85.53
34%
-12
- C1 -
-
3EQG
2
MP2K1_HUMAN
A:
[31-328]
---------------------------------------------------------
K
D
D
-
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
K
K
A
G
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
--
N
S
F
V
G
T
R
S
Y
M
S
P
E
R
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
FGC
P
-------------
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
-
S
G
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
-----------------------------------------------------
15
PsiBlast_PDB
84.95
34%
-15
- C1 -
-
3EQF
1
MP2K1_HUMAN
A:
[31-328]
---------------------------------------------------------
K
D
D
-
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
K
K
A
G
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
--
N
S
F
V
G
T
R
S
Y
M
S
P
E
R
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
GC
P
-------------
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
-
S
G
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
-----------------------------------------------------
9
PsiBlast_PDB
84.93
34%
-11
- C1 -
-
3ZLS
1
MP2K1_HUMAN
A:
[29-326]
---------------------------------------------------------
K
D
D
-
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
K
K
A
G
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
--
N
S
F
V
G
T
R
S
Y
M
S
P
E
R
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
----------
A
K
E
L
E
L
M
FGCP---
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
-
S
G
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
-----------------------------------------------------
20
PsiBlast_PDB
84.21
34%
-12
- C1 -
-
3ZLY
1
MP2K1_HUMAN
A:
[29-326]
---------------------------------------------------------
K
D
D
-
D
F
E
K
I
S
E
L
G
A
G
-
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
K
K
A
G
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
-----
V
G
T
R
S
Y
M
S
P
E
R
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
FGC
P
-------------
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
-
S
G
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
-----------------------------------------------------
4
PsiBlast_PDB
84.04
38%
-25
- C1 -
-
3SLS
2
MP2K1_HUMAN
A:
[23-282]
---------------------------------------------------------
K
D
D
-
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
K
K
A
G
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
--------
F
V
G
T
R
S
Y
M
S
P
E
R
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
G
----------------------------
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
-
S
G
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
-----------------------------------------------------
10
PsiBlast_PDB
83.98
34%
-16
- C1 -
-
3ZLX
1
MP2K1_HUMAN
A:
[29-326]
---------------------------------------------------------
K
D
D
-
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
K
K
A
G
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
-----
V
G
T
R
S
Y
M
S
P
E
R
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
----------
A
K
E
L
E
L
M
FGCP---
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
-
S
G
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
-----------------------------------------------------
2
PsiBlast_PDB
83.96
38%
-25
- C1 -
-
3OS3
2
MP2K1_HUMAN
A:
[4-269]
---------------------------------------------------------
K
D
D
-
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
K
K
A
G
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
--
N
S
F
V
G
T
R
S
Y
M
S
P
E
R
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
---------------------------
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
-----------------------------------------------------
12
PsiBlast_PDB
83.24
34%
-18
- C1 -
-
5BX0
1
MP2K1_HUMAN
A:
[29-326]
---------------------------------------------------------
K
D
D
-
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
K
K
A
G
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
--
N
S
F
V
G
T
R
S
Y
M
S
P
E
R
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
----------
A
K
E
L
E
L
M
FGCP---
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
-
S
G
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
-----------------------------------------------------
1
PsiBlast_PDB
83.12
38%
-11
- C1 -
-
3ORN
3
MP2K1_HUMAN
A:
[4-269]
---------------------------------------------------------
K
D
D
-
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
K
K
A
G
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
--
N
S
F
V
G
T
R
S
Y
M
S
P
E
R
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
-----------
P
-------------
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
-
S
G
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
-----------------------------------------------------
19
PsiBlast_PDB
82.73
34%
-14
- C1 -
-
3W8Q
1
MP2K1_HUMAN
A:
[26-323]
---------------------------------------------------------
K
D
D
-
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
K
K
A
G
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
--
N
S
F
V
G
T
R
S
Y
M
S
P
E
R
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
----------
A
K
E
L
E
L
M
F
GCQRPP
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
-
S
G
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
-----------------------------------------------------
3
PsiBlast_PDB
82.08
38%
-12
- C1 -
-
3WIG
3
MP2K1_HUMAN
A:
[4-269]
---------------------------------------------------------
K
D
D
-
D
F
E
K
I
S
E
L
G
A
G
---
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
K
K
A
G
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
--
N
S
F
V
G
T
R
S
Y
M
S
P
E
R
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
-P---------
P
-------------
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
-
S
G
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
-----------------------------------------------------
11
PsiBlast_PDB
81.99
34%
-7
- C1 -
-
3ZM4
1
MP2K1_HUMAN
A:
[29-326]
---------------------------------------------------------
K
D
D
-
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
K
K
A
G
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
------
G
T
R
S
Y
M
S
P
E
R
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
----------
A
K
E
L
E
L
M
FGCP---
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
-
S
G
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
-
K
Q
L
M
V
H
A
F
I
-----------------------------------------------------