@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_29_2780: (2018-03-11 )
MSGEAAAAEQRMRDYEVFEHLGSGATSDVYRVVNKTNNRTYVLKKMSLANMSDEEQLRAKQEIIVMDNVDHPNIVKFRESFMDPADNSVDIIMEYCEFGTLEDLIERQRYEGRPFPTDVLLEWMAELLCGLSHIHSNRILHRDLKTSNIFVTSKNHLKLGDFGVCTILSNPNAKAESMIGTPLYFAPEVCNSDPHDERSDVWSLGVVFYEMCTLRRPFEAGNLFTLIQLILESDIEPFGNGVDGSLEGLVRQMLDRDPSRRPTAQELIDVHLEVPVSHPSHPSQKPSRGRLLQQFSGPELQYTKKWPPPEGSVTVPPKSGKARATDEWIHTGSALDVFVELQRTLHRIPTAAKAKDGAAFTPSPQSAPGATLKVSSAVAKPKPEKSAKKSTGAKGTAGTTTASSSLPRTKAIEHAGAQKEDAVLGTSLLSFTMRELQLDVQRRRTSMFGEKKSLNSDDIPLVIEVQGESFSEATAAKATVSFLADIAAVIDRHTANGGQIALEALDGAACLLSEYKHLKYAR
Atome Classification :
(20 SA)
------------------------------------------------------.........10........20........30........40........50-....-....60........70........80........90........100.......110.......120.......130...---.-...140.......150..-.....160.......170.......180.......190--........200.......210......--.220.......230..--..----..-.240.......250.......260-----.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
------------------------------------------------------MSG
E
A
A
A
A
E
Q
R
M
R
D
Y
E
V
F
E
H
LGSG
A
T
S
D
V
Y
R
V
V
NKTNN
R
T
Y
V
L
K
K
MSLANM-S
D
E
E
-
Q
L
RAKQ
E
I
I
V
M
DNVDH
P
N
I
V
K
F
R
E
S
FMDPAD
N
S
V
D
I
I
M
E
Y
CEFG
T
L
E
D
L
I
E
R
QRYEGRPF
P
T
D
V
L
L
E
W
M
A
E
L
L
C
G
L
S
H
I
H---S-NR
I
L
H
R
DLKTS
N
I
F
V
TSK-N
H
L
KLGD
F
G
V
C
T
I
LSNPNA
K
A
E
SMIGTPLYFA
P
E
VCN---SDPHD
E
R
S
D
V
W
S
L
G
V
V
F
Y
E
M
C
TLRRPF--EAG
N
L
F
T
L
I
Q
L
I
L
ESD--
I
E
----PF-GNGV
D
G
S
L
E
G
L
V
R
Q
M
L
DRDPSRRP-----
T
A
Q
E
L
I
D
V
H
L
E
VPVSHPSHPSQKP
S
R
G
R
L
L
Q
QFSGPE
L
Q
Y
TKKWPPPEG
S
V
TVPPKSGKARAT
D
E
WIHTG
S
A
L
D
V
F
V
E
L
Q
R
T
L
H
RIPTAAKAKDGAAFTPSPQSAPG
A
T
L
K
V
SSAVAKPKPEKSAKKSTGAKGTAGTTTASSSLPR
T
K
A
I
E
HAGAQ
K
E
D
A
V
L
G
T
S
L
L
S
F
T
M
R
E
L
Q
L
D
V
Q
R
R
R
T
S
MFGEKKSLNSDD
I
P
L
V
I
E
VQGESFS
E
A
T
A
A
K
A
T
V
S
F
L
A
D
I
A
A
V
I
D
RHTANG
G
Q
I
A
L
EALD
G
A
A
C
L
L
S
E
Y
K
H
LKYAR
25
HHSearch
88.87
36%
-118
- C1 -
-
4APC
-
NEK1_HUMAN
B:
[16-282]
----------------------------------------------------------
E
N
L
Y
F
Q
S
M
E
K
Y
V
R
L
Q
K
I
G
-----
K
A
I
L
V
K
S
T
E
D
G
R
Q
Y
V
I
K
E
I
N
I
S
R
M
-
S
S
K
E
-
R
E
E
S
R
R
E
V
A
V
L
A
N
M
K
H
P
N
I
V
Q
Y
R
E
S
F
E
E
--
N
G
S
L
Y
I
V
M
D
Y
C
E
G
G
D
L
F
K
R
I
N
A
Q
K
--
G
V
L
F
Q
E
D
Q
I
L
D
W
F
V
Q
I
C
L
A
L
K
H
V
H
---
D
-
R
K
I
L
H
R
D
I
K
S
Q
N
I
F
L
T
K
D
-
G
T
V
Q
L
G
D
F
G
I
A
R
V
L
N
S
T
V
E
L
A
R
A
C
I
G
T
P
Y
Y
L
S
P
E
I
C
E
---
N
K
P
Y
N
N
K
S
D
I
W
A
L
G
C
V
L
Y
E
L
C
T
L
K
H
A
F
--
E
A
G
S
M
K
N
L
V
L
K
I
I
S
G
S
--
F
P
----
P
V
-
S
L
H
Y
S
Y
D
L
R
S
L
V
S
Q
L
F
K
R
N
P
R
D
R
P
-----
S
V
N
S
I
L
E
K
G
F
I
A
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
87.78
36%
-122
- C1 -
-
4B9D
2
NEK1_HUMAN
B:
[17-282]
-----------------------------------------------------------
N
L
Y
F
Q
S
M
E
K
Y
V
R
L
Q
K
I
G
-----
K
A
I
L
V
K
S
T
E
D
G
R
Q
Y
V
I
K
E
I
N
I
S
R
M
-
S
S
K
E
-
R
E
E
S
R
R
E
V
A
V
L
A
N
M
K
H
P
N
I
V
Q
Y
R
E
S
F
E
E
--
N
G
S
L
Y
I
V
M
D
Y
C
E
G
G
D
L
F
K
R
I
N
A
Q
K
--
G
V
L
F
Q
E
D
Q
I
L
D
W
F
V
Q
I
C
L
A
L
K
H
V
H
---
D
-
R
K
I
L
H
R
D
I
K
S
Q
N
I
F
L
T
K
D
-
G
T
V
Q
L
G
D
F
G
I
A
R
V
L
N
S
T
V
E
L
A
R
A
C
I
G
T
P
Y
Y
L
S
P
E
I
C
E
---
N
K
P
Y
N
N
K
S
D
I
W
A
L
G
C
V
L
Y
E
L
C
T
L
K
H
A
F
--
E
A
G
S
M
K
N
L
V
L
K
I
I
S
G
S
--
F
P
----
P
V
-
S
L
H
Y
S
Y
D
L
R
S
L
V
S
Q
L
F
K
R
N
P
R
D
R
P
-----
S
V
N
S
I
L
E
K
G
F
I
A
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
84.27
36%
-126
- C1 -
-
4APC
-
NEK1_HUMAN
A:
[21-276]
---------------------------------------------------------------
Q
S
M
E
K
Y
V
R
L
Q
K
I
------
K
A
I
L
V
K
S
T
E
D
G
R
Q
Y
V
I
K
E
I
N
I
S
R
M
-
S
S
K
E
-
R
E
E
S
R
R
E
V
A
V
L
A
N
M
K
H
P
N
I
V
Q
Y
R
E
S
F
E
E
--
N
G
S
L
Y
I
V
M
D
Y
C
E
G
G
D
L
F
K
R
I
N
A
Q
K
--
G
V
L
F
Q
E
D
Q
I
L
D
W
F
V
Q
I
C
L
A
L
K
H
V
H
---
D
-
R
K
I
L
H
R
D
I
K
S
Q
N
I
F
L
T
K
D
-
G
T
V
Q
L
G
D
F
G
I
A
R
V
L
N
S
T
V
E
L
A
R
A
C
I
G
T
P
Y
Y
L
S
P
E
I
C
E
---
N
K
P
Y
N
N
K
S
D
I
W
A
L
G
C
V
L
Y
E
L
C
T
L
K
H
A
F
--
E
A
G
S
M
K
N
L
V
L
K
I
I
S
G
S
--
F
P
----
P
V
-
S
L
H
Y
S
Y
D
L
R
S
L
V
S
Q
L
F
K
R
N
P
R
D
R
P
-----
S
V
N
S
I
L
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
83.92
36%
-129
- C1 -
-
4B9D
1
NEK1_HUMAN
A:
[21-276]
---------------------------------------------------------------
Q
S
M
E
K
Y
V
R
L
Q
K
I
------
K
A
I
L
V
K
S
T
E
D
G
R
Q
Y
V
I
K
E
I
N
I
S
R
M
-
S
S
K
E
-
R
E
E
S
R
R
E
V
A
V
L
A
N
M
K
H
P
N
I
V
Q
Y
R
E
S
F
E
E
--
N
G
S
L
Y
I
V
M
D
Y
C
E
G
G
D
L
F
K
R
I
N
A
Q
K
--
G
V
L
F
Q
E
D
Q
I
L
D
W
F
V
Q
I
C
L
A
L
K
H
V
H
---
D
-
R
K
I
L
H
R
D
I
K
S
Q
N
I
F
L
T
K
D
-
G
T
V
Q
L
G
D
F
G
I
A
R
V
L
N
S
T
V
E
L
A
R
A
C
I
G
T
P
Y
Y
L
S
P
E
I
C
E
---
N
K
P
Y
N
N
K
S
D
I
W
A
L
G
C
V
L
Y
E
L
C
T
L
K
H
A
F
--
E
A
G
S
M
K
N
L
V
L
K
I
I
S
G
S
--
F
P
----
P
V
-
S
L
H
Y
S
Y
D
L
R
S
L
V
S
Q
L
F
K
R
N
P
R
D
R
P
-----
S
V
N
S
I
L
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
78.64
31%
-123
- C1 -
-
2W5B
1
NEK2_HUMAN
A:
[3-273]
---------------------------------------------------------------
S
R
A
E
D
Y
E
V
L
Y
T
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
-
T
E
A
E
-
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
---
R
-
R
S
-
L
H
R
D
L
K
P
A
N
V
F
L
D
G
K
-
Q
N
V
K
L
G
D
F
G
L
A
R
I
L
N
H
D
T
S
F
A
K
A
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
---
R
M
S
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
--
T
A
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
--
F
R
----
R
I
-
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
-----
S
V
E
E
I
L
E
N
P
L
I
L
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
77.69
31%
-126
- C1 -
-
2W5A
5
NEK2_HUMAN
A:
[4-273]
----------------------------------------------------------------
R
A
E
D
Y
E
V
L
Y
T
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
-
T
E
A
E
-
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
---
R
-
R
S
-
L
H
R
D
L
K
P
A
N
V
F
L
D
G
K
-
Q
N
V
K
L
G
D
F
G
L
A
R
I
L
---
T
S
F
A
K
T
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
---
R
M
-
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
--
T
A
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
--
F
R
----
R
I
-
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
-----
S
V
E
E
I
L
E
N
P
L
I
L
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
68.01
31%
-75
- C1 -
-
2W5A
5
NEK2_HUMAN
A:
[4-267]
----------------------------------------------------------------
R
A
E
D
Y
E
V
L
Y
T
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
-
T
E
A
E
-
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S-----
L
H
R
D
L
K
P
A
N
V
F
L
D
G
K
-
Q
N
V
K
L
G
D
F
G
L
A
R
I
L
---
T
S
F
A
K
T
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
---
R
M
-
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
--
T
A
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
--
F
R
----
R
I
-
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
-----
S
V
E
E
I
L
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
Fugue
66.00
24%
-19
- C1 -
-
4DN5
7
M3K14_HUMAN
A:
[8-351]
S
V
E
E
Y
L
V
H
A
L
QG
S
V
S
S
G
Q
A
H
S
L
T
S
L
A
K
T
W
A
A
R
G
S
RSREPSPKTE
D
N
E
G
V
L
LTEK
L
K
P
V
D
Y
E
Y
R
E
E
V
H
W
A
T
H
Q
L
R
L
G
R
G
S
F
G
E
V
H
R
M
E
D
K
Q
T
G
F
Q
C
A
V
K
K
V
R
L
E
V
F
---------
R
A
E
E
L
M
A
C
A
G
L
T
S
P
R
I
V
P
L
Y
G
A
V
R
E
--
G
P
W
V
N
I
F
M
E
L
L
E
G
G
S
L
G
Q
L
V
K
E
Q
G
----
C
L
P
E
D
R
A
L
Y
Y
L
G
Q
A
L
E
G
L
E
Y
L
H
---
S
-
R
R
I
L
H
G
D
V
K
A
D
N
V
L
L
S
S
D
G
S
H
A
A
L
C
D
F
G
H
--------
A
V
C
L
Q
I
P
G
T
E
T
H
M
A
P
E
V
V
L
---
G
R
S
C
D
A
K
V
D
V
W
S
S
C
C
M
M
L
H
M
L
N
G
C
H
P
W
--
T
Q
F
F
R
G
P
L
C
L
K
I
A
S
E
P
PP
V
R
----
E
I
-
P
P
S
C
A
P
L
T
A
Q
A
I
Q
E
G
L
R
K
E
P
I
H
R
V
-----
S
A
A
E
L
G
G
K
V
N
R
A
L
Q
Q
V
G
G
L
K
S
P
W
R
G
E
Y
K
E
P
R
H
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
62.55
31%
-76
- C1 -
-
2XNO
13
NEK2_HUMAN
A:
[4-267]
----------------------------------------------------------------
R
A
E
D
Y
E
V
L
Y
T
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
-
T
E
A
E
-
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S-------
R
D
L
K
P
A
N
V
F
L
D
G
K
-
Q
N
V
K
L
G
D
F
---------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
---
R
---
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
--
T
A
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
--
F
R
----
R
I
-
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
-----
S
V
E
E
I
L
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
61.84
31%
-74
- C1 -
-
2XKF
1
NEK2_HUMAN
A:
[4-267]
----------------------------------------------------------------
R
A
E
D
Y
E
V
L
Y
T
I
G
T
G
---
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
-
T
E
A
E
-
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S-------
R
D
L
K
P
A
N
V
F
L
D
G
K
-
Q
N
V
K
L
G
D
F
---------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
---
R
-
S
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
--
T
A
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
--
F
R
----
R
I
-
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
-----
S
V
E
E
I
L
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
60.87
31%
-72
- C1 -
-
2XK3
1
NEK2_HUMAN
A:
[4-267]
----------------------------------------------------------------
R
A
E
D
Y
E
V
L
Y
T
I
G
T
----
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
-
T
E
A
E
-
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S-------
R
D
L
K
P
A
N
V
F
L
D
G
K
-
Q
N
V
K
L
G
D
F
G
---------------
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
---
R
---
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
--
T
A
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
--
F
R
----
R
I
-
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
-----
S
V
E
E
I
L
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
60.51
31%
-47
- C1 -
-
5DE2
-
NEK7_HUMAN
A:
[31-291]
-----------------------------------------------------------------
L
A
N
F
R
I
E
K
K
I
G
R
G
Q
F
S
E
V
Y
R
A
A
C
L
L
D
G
V
P
V
A
L
K
K
V
Q
I
F
D
L
-
M
D
A
K
A
R
A
D
C
I
K
E
I
D
L
L
K
Q
L
N
H
P
N
V
I
K
F
Y
A
S
F
I
E
--
D
N
E
L
N
I
V
L
E
L
A
D
A
G
D
L
S
R
M
I
K
H
F
K
K
Q
K
R
L
I
P
E
R
T
V
W
K
Y
F
V
Q
L
C
S
A
L
E
H
M
H
---
S
-
R
R
V
M
H
R
D
I
K
P
A
N
V
F
I
T
A
T
-
G
V
V
K
L
G
D
L
G
L
--------------
V
G
T
P
Y
Y
M
S
P
E
R
I
H
---
E
N
G
Y
N
F
K
S
D
I
W
S
L
G
C
L
L
Y
E
M
A
A
L
Q
S
P
F
YG
D
K
M
N
L
Y
S
L
C
K
K
I
E
Q
C
D
--
Y
P
----
P
L
P
S
D
H
Y
S
E
E
L
R
Q
L
V
N
M
C
I
N
P
D
P
E
K
R
P
-----
D
V
T
Y
V
Y
D
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
59.94
31%
-71
- C1 -
-
2XNP
6
NEK2_HUMAN
A:
[4-267]
----------------------------------------------------------------
R
A
E
D
Y
E
V
L
Y
T
I
G
T
G
-
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
-
T
E
A
E
-
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S------
H
R
D
L
K
P
A
N
V
F
L
D
G
K
-
Q
N
V
K
L
G
D
F
G
L
-------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
---
R
---
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
--
T
A
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
--
F
R
----
R
I
-
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
-----
S
V
E
E
I
L
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
59.84
30%
-17
- C1 -
-
4GV1
5
AKT1_HUMAN
A:
[6-276]
----------------------------------------------------------------
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
T
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
K
D
E
-
V
A
H
T
L
T
E
N
R
V
L
Q
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
--
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
----
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
---
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
-
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
A
T
M
K
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
---
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
--
Y
N
Q
D
H
E
K
L
F
E
L
I
L
M
E
E
--
I
-----
R
F
-
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
GGGS
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
59.64
31%
-69
- C1 -
-
2XK6
1
NEK2_HUMAN
A:
[4-267]
----------------------------------------------------------------
R
A
E
D
Y
E
V
L
Y
T
I
G
-----
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
-
T
E
A
E
-
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S-------
R
D
L
K
P
A
N
V
F
L
D
G
K
-
Q
N
V
K
L
G
D
-----------------
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
---
R
---
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
--
T
A
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
--
F
R
----
R
I
-
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
-----
S
V
E
E
I
L
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
59.18
31%
-58
- C1 -
-
2XNM
10
NEK2_HUMAN
A:
[4-267]
----------------------------------------------------------------
R
A
E
D
Y
E
V
L
Y
T
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
-
T
E
A
E
-
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R--------
R
D
L
K
P
A
N
V
F
L
D
G
K
-
Q
N
V
K
L
G
D
F
G
L
A
R
I
L
---------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
---
R
-
S
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
--
T
A
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
--
F
R
----
R
I
-
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
-----
S
V
E
E
I
L
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
58.45
31%
-71
- C1 -
-
2XNN
6
NEK2_HUMAN
A:
[4-267]
----------------------------------------------------------------
R
A
E
D
Y
E
V
L
Y
T
I
G
T
--
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
-
T
E
A
E
-
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S-------
R
D
L
K
P
A
N
V
F
L
D
G
K
-
Q
N
V
K
L
G
D
F
G
--------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
---
R
--
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
--
T
A
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
--
F
R
----
R
I
-
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
-----
S
V
E
E
I
L
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
57.88
31%
-72
- C1 -
-
2XK4
1
NEK2_HUMAN
A:
[4-267]
----------------------------------------------------------------
R
A
E
D
Y
E
V
L
Y
T
I
G
T
--
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
-
T
E
A
E
-
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S-------
R
D
L
K
P
A
N
V
F
L
D
G
K
-
Q
N
V
K
L
G
D
F
G
L
-------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
---
R
M
--
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
--
T
A
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
--
F
R
----
R
I
-
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
-----
S
V
E
E
I
L
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
57.46
31%
-71
- C1 -
-
2XK8
1
NEK2_HUMAN
A:
[4-267]
----------------------------------------------------------------
R
A
E
D
Y
E
V
L
Y
T
I
G
T
----
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
-
T
E
A
E
-
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S-------
R
D
L
K
P
A
N
V
F
L
D
G
K
-
Q
N
V
K
L
G
D
F
---------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
-------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
--
T
A
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
--
F
R
----
R
I
-
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
-----
S
V
E
E
I
L
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
56.93
30%
-75
- C1 -
-
5J5T
1
M4K3_HUMAN
A:
[3-267]
-----------------------------------------------------------------
Q
E
D
F
E
L
I
Q
R
I
G
S
G
T
Y
G
D
V
Y
K
A
R
N
V
N
T
G
E
L
A
A
I
K
V
I
K
L
E
P
G
---
E
D
-
F
A
V
V
Q
Q
E
I
I
M
M
K
D
C
K
H
P
N
I
V
A
Y
F
G
S
Y
L
R
--
R
D
K
L
W
I
C
M
E
F
C
G
G
G
S
L
Q
D
I
Y
H
V
T
----
G
P
L
S
E
L
Q
I
A
Y
V
S
R
E
T
L
Q
G
L
Y
Y
L
H
---
S
-
K
G
K
M
H
R
D
I
K
G
A
N
I
L
L
T
D
N
-
G
H
V
K
L
A
D
F
G
V
S
A
Q
I
T
A
T
I
A
---
A
F
I
G
T
P
Y
W
M
A
P
E
V
A
A
V
ER
K
G
G
Y
N
Q
L
C
D
L
W
A
V
G
I
T
A
I
E
L
A
E
L
Q
P
P
M
--
F
D
L
H
P
M
R
A
L
F
L
M
T
K
S
N
--
F
Q
P
P
KL
K
D
-
K
M
K
W
S
N
S
F
H
H
F
V
K
M
A
L
T
K
N
P
K
K
R
P
-----
T
A
E
K
L
L
Q
H
P
F
V
T
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------