@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_30_0850: (2018-03-11 )
MSGYLKVLSPDGRWETRYVEIDDAKLRIWRTKGDKESSAAVVKELDLKCATLREVSEPNTWAVQPEKAEATYFQADGEERKTEWMDTLRHYNSSSSASEKVTLRDFEKKFVLGKGSYGKVFMVVKKDTDKWYAMKEMSAEKMRQAEIKAPFAERIILEEIDHPFIVHLHYSFQEQGNLYMILDLLAGGELFTYIEQHAPLDEEVVKFYAAEVALALGYLHSRNIIYRDLKPENVVFDRDGHACLTDFGLAKANVHEPNAVTYCGTNEYLAPELLKGVPHGKAVDWWSLGLMMCEMLFNDLPFYDENPMQMQMKILTEDVAFPPHIQITEETKDLIRCLLNKNPERRLQTLEAFKAHKCFSNLDFGLLEARKLKAPITPDPNPAHNFAKEFTSEVIVQNESPSQAVVTLAGYTYDRDLSEQEKSPSHSPTIAEELRQRRASMKKSTNGSDAASPPVTGENRTSNSSPAGAPTKQAAAGPVKKVEHHIPAKVAPQAARKKLTGNKSFDKPTK
Atome Classification :
(32 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.---..---..---..130......-.140...--.....150.......-.160........170.......180.......190.......200.......210.......220........230.......240.......250..-..-.-..260........270.......280.......290.......300.......----310.......320.......330.......340.....----.----.-----350---..----.---......360.......370......--.---380........390.......-----400---.........410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MSG
Y
L
K
V
LSPDGR
W
E
T
R
Y
V
E
IDDA
K
L
R
I
W
R
TKGDK
E
S
S
A
A
V
V
K
E
LD
L
K
C
A
T
L
R
EVSEPN
T
W
A
VQPEKAE
A
T
Y
F
QADG
E
E
R
K
T
E
W
M
D
T
L
R
HYNSSSSAS
E
K
V
T
L
R
D
F
E
K
K
F
V
LGKGSY
G
K
V
F
M
V
---
V
K---KD---TD
K
W
Y
A
M
K
E
M
S
-
A
E
K
-
M
R
Q
--
A
EIKA
P
F
-
A
E
R
I
I
L
E
-EI-DH
P
F
I
V
H
L
H
Y
S
FQEQG
N
L
Y
M
I
L
D
L
LAG
G
E
L
F
T
Y
I
E
Q
HAP
L
D
E
E
V
V
K
F
Y
A
A
E
V
A
L
A
L
G
Y
L
HS-RN
I
I
Y
RDLKPE
N
V
V
FDRDG
H
A
C
L
T
DFGLAKANV-HE-P-N
A
V
-
T
YCGTNEYL
A
P
E
L
L
KGVPHGKA
V
D
W
W
S
L
G
L
M
M
C
E
M
L
FNDLPFYDEN
P
M
Q
----
M
Q
M
K
I
L
TEDVAFPP
H
I
Q
I
T
E
E
T
K
D
L
I
R
C
L
LNK
N
P
E
R
R
L
----
Q
----
T
-----
L
-----
E
A
----
F
---
K
A
H
K
C
F
S
NL
D
F
G
L
L
E
A
R
KLKAPITP--D---P-
N
P
A
H
N
F
A
K
E
F
T
S
E
V
I
VQNE-----S-----PS
Q
A
V
V
T
L
AGYTYDRDL
S
E
QEKSPSHS
P
T
I
A
E
E
L
R
Q
R
R
A
SMKKSTNGSDAASPPVTGENRTSNSSPAGAPTKQAAAG
P
V
K
K
V
E
H
HIPAKV
A
P
Q
A
A
R
K
KLTGNKSFDKPTK
41
HHSearch
73.66
39%
-43
- C1 -
-
4WB8
2
KAPCA_HUMAN
A:
[23-318]
--------------------------------------------------------------------------------------------------
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
---
K
H
---
K
E
---
T
G
N
H
Y
A
M
K
I
L
D
-
K
Q
K
-
V
V
K
L
-
K
Q
I
E
H
T
L
-
N
E
K
R
I
L
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
K
-
G
R
----
T
W
-
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
----
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
--
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
----
G
----
N
LKN
G
-
V
-----
N
D
----
I
---
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
--
K
FKG
P
-
G
D
T
S
N
F
D
D
Y
E
----------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
73.61
38%
-44
- C1 -
-
4WIH
-
KAPCA_CRIGR
A:
[39-336]
--------------------------------------------------------------------------------------------------
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
---
K
H
---
K
E
---
T
G
N
H
Y
A
M
K
I
L
D
-
K
Q
K
-
V
V
K
L
-
K
Q
I
E
H
T
L
-
N
E
K
R
I
L
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
K
-
G
----
R
T
W
-
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
----
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
--
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
----
G
----
N
LKNG-
V
-----
N
D
----
I
---
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
--
K
FKG
P
-
G
D
T
S
N
F
D
D
Y
E
E
E
--------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
73.31
40%
-101
- C1 -
-
2R5T
1
SGK1_HUMAN
A:
[34-320]
---------------------------------------------------------------------------------------------------
H
A
K
P
S
D
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
---
R
H
---
K
A
---
E
E
V
F
Y
A
V
K
V
L
Q
-
K
K
A
-
I
L
--------------
V
L
L
K
-
N
V
-
K
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
E
R
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
-
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
H
I
V
L
T
D
F
G
L
C
K
E
N
I
-
E
H
-
N
S
T
T
S
-
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
H
K
Q
P
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
F
Y
S
R
N
T
A
E
----
M
Y
D
N
I
L
N
K
P
L
Q
L
K
P
--
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
----
G
----
A
-----
K
DD
F
--
M
E
----
I
---
K
S
H
V
F
F
S
L
I
N
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
--
N
VSG----------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
71.13
40%
-96
- C1 -
-
3HDM
1
SGK1_HUMAN
A:
[34-320]
---------------------------------------------------------------------------------------------------
H
A
K
P
S
D
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
---
R
H
---
K
A
---
E
E
V
F
Y
A
V
K
V
L
Q
-
K
K
A
-
I
L
--------------
V
L
L
K
-
N
V
-
K
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
E
R
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
-
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
H
I
V
L
T
D
F
G
L
C
K
E
N
I
-
E
H
-
N
S
T
T
S
-
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
H
K
Q
P
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
F
Y
S
R
N
T
A
E
----
M
Y
D
N
I
L
N
K
P
L
Q
L
K
P
--
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
----
G
----
A
-----
K
DD
F
--
M
E
----
I
---
K
S
H
V
F
F
S
L
I
N
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
--
N
VSG----------------------------------------------------------------------------------------------------------------------------------------------
43
HHSearch
70.65
38%
-43
- C1 -
-
1RDQ
3
KAPCA_MOUSE
E:
[37-332]
---------------------------------------------------------------------------------------------------
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
---
K
H
---
K
E
---
S
G
N
H
Y
A
M
K
I
L
D
-
K
Q
K
-
V
V
K
L-
K
Q
I
E
H
T
L
-
N
E
K
R
I
L
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
K
-
G
----
R
T
W
-
T
L
C
G
T
P
E
A
L
A
P
E
I
I
L
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
----
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
--
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
----
G
NLKN
G
-----
V
-----
N
D
----
I
---
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
--
K
FKG
P
-
G
D
T
S
N
F
D
D
Y
E
E
---------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
68.49
43%
0
- C- -
-
4NUS
1
KS6A3_HUMAN
A:
[23-316]
------------------------------------------------------------------------------------------------
G
H
E
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
---
K
K
ISG
S
D
---
A
R
Q
L
Y
A
M
K
V
L
K
-
K
A
T
-
L
K
V
--
R
D
R
V
R
T
K
-
M
E
R
D
I
L
V
-
E
V
-
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
S
I
D
H
E
-
K
-
K
A
Y
-
S
F
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
D
R
K
E
----
T
M
T
M
I
L
K
A
K
L
G
M
P
Q
F
--
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
GAGP
D
----
G
-----
V
-----
E
E
----
I
---
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
68.49
43%
0
- C- -
-
4NW6
1
KS6A3_HUMAN
A:
[23-317]
------------------------------------------------------------------------------------------------
G
H
E
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
---
K
K
I
S
G
S
D
---
A
R
Q
L
Y
A
M
K
V
L
K
-
K
A
T
-
L
K
V
--
R
D
R
V
R
T
K
-
M
E
R
D
I
L
V
-
E
V
-
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
S
I
D
H
E
-
K
-
K
A
Y
-
S
F
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
D
R
K
E
----
T
M
T
M
I
L
K
A
K
L
G
M
P
Q
F
--
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
GAGP
D
----
G
-----
V
-----
E
E
----
I
---
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
68.49
43%
0
- C- -
-
4NW5
1
KS6A3_HUMAN
A:
[23-317]
------------------------------------------------------------------------------------------------
G
H
E
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
---
K
K
ISG
S
D
---
A
R
Q
L
Y
A
M
K
V
L
K
-
K
A
T
-
L
K
V
--
R
D
R
V
R
T
K
-
M
E
R
D
I
L
V
-
E
V
-
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
S
I
D
H
E
-
K
-
K
A
Y
-
S
F
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
D
R
K
E
----
T
M
T
M
I
L
K
A
K
L
G
M
P
Q
F
--
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
GAGP
D
----
G
-----
V
-----
E
E
----
I
---
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
67.83
40%
0
- C- -
-
4GV1
5
AKT1_HUMAN
A:
[5-312]
----------------------------------------------------------------------------------------------------
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
---
K
E
---
K
A
---
T
G
R
Y
Y
A
M
K
I
L
K
-
K
E
V
-
I
V
A
K
-
D
E
V
A
H
T
L
-
T
E
N
R
V
L
Q
-
N
S
-
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
-
K
D
-
G
A
T
M
K
-
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
E
K
----
L
F
E
L
I
L
M
E
E
I
R
F
P
R
--
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
----
G
GGS
E
D
-----
A
-----
K
E
----
I
---
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
--
Q
VTS
E
-
T
D
T
R
Y
F
D
E
E
F
T
A
Q
M
I
-----------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
66.68
40%
-48
- C1 -
-
2R5T
1
SGK1_HUMAN
A:
[26-320]
-------------------------------------------------------------------------------------------
N
L
G
P
S
S
N
P
H
A
K
P
S
D
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
---
R
H
---
K
A
---
E
E
V
F
Y
A
V
K
V
L
Q
-
K
K
A
I
L
---------------
V
L
L
K
-
N
V
-
K
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
E
R
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
-
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
H
I
V
L
T
D
F
G
L
C
K
E
N
I
E
H
N
-
S
-
T
T
S
-
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
H
K
Q
P
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
F
Y
S
R
N
T
A
E
----
M
Y
D
N
I
L
N
K
P
L
Q
L
K
P
N
--
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
----
G
----
A
-----
K
-----
D
D
----
F
M
E
I
K
S
H
V
F
F
S
L
I
N
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
--
N
VSG----------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
66.21
44%
-8
- C1 -
-
4L3L
1
KS6B1_HUMAN
A:
[14-300]
---------------------------------------------------------------------------------------------------
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
---
R
K
VTG
A
N
---
T
G
K
I
F
A
M
K
V
L
K
K
A
M
I
-
V
R
N
--
A
K
D
T
A
H
T
K
A
E
R
N
I
L
E
-
E
V
-
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
-
H
D
-
G
-
T
V
T
H
T
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
R
K
K
----
T
I
D
K
I
L
K
C
K
L
N
L
P
P
Y
--
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
----
G
----
A
-----
G
-----
P
G
D
A
G
E
V
---
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
66.17
35%
-16
- C1 -
-
5LI9
13
KPCI_HUMAN
A:
[3-343]
----------------------------------------------------------------------------------------------------
L
G
L
Q
D
F
D
L
L
R
V
I
G
R
G
S
Y
A
K
V
L
L
V
---
R
L
---
K
K
---
T
D
R
I
Y
A
M
K
V
V
K
-
K
E
L
-
V
N
D
D
-
E
D
I
D
W
V
Q
-
T
E
K
H
V
F
E
-
Q
A
S
N
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
E
G
L
-
R
P
G
D
-
T
T
S
-
T
F
C
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
D
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
S
P
F
-------
T
E
D
Y
L
F
Q
V
I
L
E
K
Q
I
R
I
P
R
--
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
R
L
----
G
----
C
HPQ
T
G
F
-----
A
D
----
I
---
Q
G
H
P
F
F
R
N
V
D
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
--
N
I
S
G
E
-
F
G
L
D
N
F
D
S
Q
F
T
N
E
P
V
Q
L
T
P
-----
D
D
D
D
I
V
R
K
I
D
Q
S
E
F
E
G
F
E
Y
I
N
P
L
L
--------------------------------------------------------------------------------------------
39
HHSearch
65.99
45%
-11
- C1 -
-
3WF7
2
KS6B1_HUMAN
A:
[15-304]
---------------------------------------------------------------------------------------------------
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
---
R
K
---
V
T
GAN
T
G
K
I
F
A
M
K
V
L
K
-
K
A
M
-
I
V
R
N
A
K
D
T
A
H
T
K
-
A
E
R
N
I
L
E
-
E
V
-
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
-
H
D
----
T
H
-
T
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
R
K
K
----
T
I
D
K
I
L
K
C
K
L
N
L
P
P
--
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
----
G
AGP
G
D
-----
A
-----
G
E
----
V
---
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
--
L
---
L
Q--------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
65.19
35%
-14
- C1 -
-
3A8X
-
KPCI_HUMAN
A:
[5-344]
---------------------------------------------------------------------------------------------------
P
L
G
L
Q
D
F
D
L
L
R
V
I
G
R
G
S
Y
A
K
V
L
L
V
---
R
L
---
K
K
---
T
D
R
I
Y
A
M
K
V
V
K
-
K
E
L
-
V
N
D
D
-
E
D
I
D
W
V
Q
-
T
E
K
H
V
F
E
-
Q
A
S
N
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
E
G
L
-
R
P
-
G
D
T
T
S
-
T
F
C
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
D
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
S
P
F
D
I
V
G
S
--T
E
D
Y
L
F
Q
V
I
L
E
K
Q
I
R
I
P
R
--
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
R
L
----
G
----
C
-----
H
PQ
T
G
F
A
D
----
I
---
Q
G
H
P
F
F
R
N
V
D
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
--
N
I
S
G
E
-
F
G
L
D
N
F
D
S
Q
F
T
N
E
P
V
Q
L
T
P
D
D
D
D
I
V
-----
R
K
I
D
Q
S
E
F
E
G
F
E
Y
I
N
P
----------------------------------------------------------------------------------------------
45
HHSearch
64.48
39%
-48
* C1 *
-
2UZV
1
KAPCA_BOVIN
A:
[23-303]
---------------------------------------------------------------------------------------------------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
---
K
H
---
M
E
---
T
G
N
H
Y
A
M
K
I
L
D
-
K
Q
K
-
V
V
K
L
-
K
Q
I
E
H
T
L
-
N
E
K
R
I
L
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
K
-
G
----
R
T
W
-
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
----
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
--
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
----
G
NLKD
G
-----
V
-----
N
D
----
I
---
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
--
K
-------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
64.11
40%
-49
- C1 -
-
3HDN
1
SGK1_HUMAN
A:
[26-316]
-------------------------------------------------------------------------------------------
N
L
G
P
S
S
N
P
H
A
K
P
S
D
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
---
R
H
---
K
A
---
E
E
V
F
Y
A
V
K
V
L
Q
-
K
K
A
I
L
---------------
V
L
L
K
-
N
V
-
K
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
E
R
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
-
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
H
I
V
L
T
D
F
G
L
C
K
E
N
I
E
H
N
-
S
-
T
T
S
-
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
H
K
Q
P
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
F
Y
S
R
N
T
A
E
----
M
Y
D
N
I
L
N
K
P
L
Q
L
K
P
N
--
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
----
G
----
A
-----
K
-----
D
D
----
F
M
E
I
K
S
H
V
F
F
S
L
I
N
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
----------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
64.10
40%
-45
- C1 -
-
3HDM
1
SGK1_HUMAN
A:
[26-320]
-------------------------------------------------------------------------------------------
N
L
G
P
S
S
N
P
H
A
K
P
S
D
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
---
R
H
---
K
A
---
E
E
V
F
Y
A
V
K
V
L
Q
-
K
K
A
I
L
---------------
V
L
L
K
-
N
V
-
K
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
E
R
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
-
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
H
I
V
L
T
D
F
G
L
C
K
E
N
I
E
H
N
-
S
-
T
T
S
-
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
H
K
Q
P
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
F
Y
S
R
N
T
A
E
----
M
Y
D
N
I
L
N
K
P
L
Q
L
K
P
N
--
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
----
G
----
A
-----
K
-----
D
D
----
F
M
E
I
K
S
H
V
F
F
S
L
I
N
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
--
N
VSG----------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
63.71
44%
-6
- C1 -
-
4L3J
1
KS6B1_HUMAN
A:
[14-300]
---------------------------------------------------------------------------------------------------
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
---
R
K
VTG
A
N
---
T
G
K
I
F
A
M
K
V
L
K
K
A
M
I
-
V
R
N
--
A
K
D
T
A
H
T
K
A
E
R
N
I
L
E
-
E
V
-
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
-
H
D
-
G
-
T
V
T
H
T
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
R
K
K
----
T
I
D
K
I
L
K
C
K
L
N
L
P
P
Y
--
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
----
G
----
A
-----
G
-----
P
G
D
A
G
E
V
---
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
63.62
33%
-1
- C1 -
-
5F9E
1
KPCT_HUMAN
A:
[15-342]
---------------------------------------------------------------------------------------------------
K
L
K
I
E
D
F
E
L
H
K
M
L
G
K
G
S
F
G
K
V
F
L
A
---
E
F
---
K
K
---
T
N
Q
F
F
A
I
K
A
L
K
-
K
D
V
-
V
L
M
D
-
D
D
V
E
C
T
M
-
V
E
K
R
V
L
S
L
A
W
-
E
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
C
H
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
D
G
H
I
K
I
A
D
F
G
M
C
K
E
N
M
-
L
G
D
A
-
K
T
N
-
E
F
C
G
T
P
D
Y
I
A
P
E
I
L
L
G
Q
K
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
S
P
F
H
G
Q
D
E
E
E
----
L
F
H
S
I
R
M
D
N
P
F
Y
P
R
--
W
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
R
L
----
G
----
V
-----
R
-----
G
D
----
I
---
R
Q
H
P
L
F
R
E
I
N
W
E
E
L
E
R
K
E
I
D
P
P
F
R
P
--
K
VKS
P
-
F
D
C
S
N
F
D
K
E
F
L
N
E
K
P
R
L
S
F
A----
D
R
A
L
I
-
N
S
M
D
Q
N
M
F
R
N
F
S
F
M
N
P
G
M
--------------------------------------------------------------------------------------------
20
PsiBlast_PDB
63.37
44%
-11
- C1 -
-
3WE4
1
KS6B1_HUMAN
A:
[15-301]
---------------------------------------------------------------------------------------------------
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
---
R
K
VTG
A
N
---
T
G
K
I
F
A
M
K
V
L
K
K
A
M
I
-
V
R
N
--
A
K
D
T
A
H
T
K
A
E
R
N
I
L
E
-
E
V
-
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
-
H
D
-----
T
H
T
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
R
K
K
----
T
I
D
K
I
L
K
C
K
L
N
L
P
P
Y
--
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
----
G
----
A
-----
G
-----
P
G
D
A
G
E
V
---
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
61.90
33%
2
- C1 -
-
4RA5
3
KPCT_HUMAN
A:
[2-328]
----------------------------------------------------------------------------------------------------
L
K
I
E
D
F
E
L
H
K
M
L
G
K
G
S
F
G
K
V
F
L
A
---
E
F
---
K
K
---
T
N
Q
F
F
A
I
K
A
L
K
-
K
D
V
-
V
L
M
D
-
D
D
V
E
C
T
M
-
V
E
K
R
V
L
S
L
A
W
-
E
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
C
H
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
D
G
H
I
K
I
A
D
F
G
M
C
K
E
N
M
-
L
G
-
D
A
K
T
N
-
E
F
C
G
T
P
D
Y
I
A
P
E
I
L
L
G
Q
K
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
S
P
F
H
G
Q
D
E
E
E
----
L
F
H
S
I
R
M
D
N
P
F
Y
P
R
--
W
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
R
L
----
G
----
V
-----
R
-----
G
D
----
I
---
R
Q
H
P
L
F
R
E
I
N
W
E
E
L
E
R
K
E
I
D
P
P
F
R
P
--
K
VKS
P
-
F
D
C
S
N
F
D
K
E
F
L
N
E
K
P
R
L
S
F
A----
D
R
A
L
I
-
N
S
M
D
Q
N
M
F
R
N
F
S
F
M
N
P
G
M
--------------------------------------------------------------------------------------------
2
PsiBlast_PDB
60.05
42%
13
- C1 -
-
5D9K
2
KS6A3_HUMAN
A:
[26-323]
---------------------------------------------------------------------------------------------------
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
---
K
K
ISG
S
D
---
A
R
Q
L
Y
A
M
K
V
L
K
-
K
A
T
-
L
K
V
--
R
D
R
V
R
T
K
-
M
E
R
D
I
L
V
-
E
V
-
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
---------------
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
D
R
K
E
----
T
M
T
M
I
L
K
A
K
L
G
M
P
Q
F
--
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
GAGP
D
----
G
-----
V
-----
E
E
----
I
---
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
AT---------
F
Y
F
D
P
------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
59.35
43%
17
- C1 -
-
5D9L
2
KS6A3_HUMAN
A:
[23-310]
------------------------------------------------------------------------------------------------
G
H
E
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
---
K
K
I
S
G
S
D
---
A
R
Q
L
Y
A
M
K
V
L
K
-
K
A
T
-
L
K
V
--
R
D
R
V
R
T
K
-
M
E
R
D
I
L
V
-
E
V
-
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
---------------
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
D
R
K
E
----
T
M
T
M
I
L
K
A
K
L
G
M
P
Q
F
--
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
GAGP
D
----
G
-----
V
-----
E
E
----
I
---
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
55.06
44%
-15
- C1 -
-
3A60
1
KS6B1_HUMAN
A:
[13-299]
---------------------------------------------------------------------------------------------------
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
---
R
K
V
T
G
A
N
---
T
G
K
I
F
A
M
K
V
L
K
K
A
M
--------------K
A
E
R
N
I
L
E
-
E
V
-
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
----------------
T
I
E
Y
M
A
P
E
I
L
M
R
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
R
K
K
----
T
I
D
K
I
L
K
C
K
L
N
L
P
P
Y
--
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
----
G
----
A
-----
G
-----
P
G
D
A
G
E
V
---
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
55.05
43%
9
- C1 -
-
4GUE
1
KS6A3_MOUSE
A:
[18-305]
------------------------------------------------------------------------------------------------
G
H
E
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
---
K
K
ISG
S
D
---
A
R
Q
L
Y
A
M
K
V
L
K
-
K
A
T
-
L
K
V
--
R
D
R
V
---------
L
V
-
E
V
-
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
------
K
-
K
A
Y
-
S
F
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
D
R
K
E
----
T
M
T
M
I
L
K
A
K
L
G
M
P
Q
F
--
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
----
G
----
A
GPD
G
-
V
-----
E
E
----
I
---
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
53.63
42%
16
- C1 -
-
3G51
1
KS6A3_MOUSE
A:
[17-304]
------------------------------------------------------------------------------------------------
G
H
E
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
---
K
K
ISG
S
D
---
A
R
Q
L
Y
A
M
K
V
L
K
-
K
A
T
-
L
K
V
--
R
D
----------
I
L
V
-
E
V
-
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
S
I
--------------
T
V
E
Y
M
A
P
E
V
V
N
R
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
D
R
K
E
----
T
M
T
M
I
L
K
A
K
L
G
M
P
Q
F
--
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
GAGP
D
----
G
-----
V
-----
E
E
----
I
---
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
53.13
43%
12
- C1 -
-
4EL9
1
KS6A3_MOUSE
A:
[18-305]
------------------------------------------------------------------------------------------------
G
H
E
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
---
K
K
ISG
S
D
---
A
R
Q
L
Y
A
M
K
V
L
K
-
K
A
T
-
L
K
V
--
R
D
R
V
R
------
D
I
L
V
-
E
V
-
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
S
---
E
-
K
-
K
A
Y
-
S
F
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
D
R
K
E
----
T
M
T
M
I
L
K
A
K
L
G
M
P
Q
F
--
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
----
G
----
A
GPD
G
-
V
-----
E
E
----
I
---
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
52.68
43%
3
- C1 -
-
3UBD
1
KS6A3_MOUSE
A:
[17-304]
------------------------------------------------------------------------------------------------
G
H
E
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
---
K
K
ISG
S
D
---
A
R
Q
L
Y
A
M
K
V
L
K
-
K
A
T
-
L
K
V
--
R
D
R
V
-------
D
I
L
V
-
E
V
-
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
------
K
-
K
A
Y
-
S
F
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
D
R
K
E
----
T
M
T
M
I
L
K
A
K
L
G
M
P
Q
F
--
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
----
G
----
A
GPD
G
-
V
-----
E
E
----
I
---
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
51.39
42%
12
- C1 -
-
2Z7S
1
KS6A1_HUMAN
A:
[24-308]
---------------------------------------------------------------------------------------------------
K
A
D
P
S
H
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
RKV
T
R
---
P
D
---
S
G
H
L
Y
A
M
K
V
L
K
----------------------
I
L
A
-
D
V
-
N
H
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
---------------
G
T
V
E
Y
M
A
P
E
V
V
N
R
Q
G
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
L
P
F
Q
G
K
D
R
K
E
----
T
M
T
L
I
L
K
A
K
L
G
M
P
Q
F
--
L
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
R
L
----
G
----
S
GPD
G
-
A
-----
E
E
----
I
---
K
R
H
V
F
Y
S
T
I
D
W
N
K
L
Y
R
R
E
I
K
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
51.23
42%
11
- C1 -
-
2Z7Q
1
KS6A1_HUMAN
A:
[24-308]
---------------------------------------------------------------------------------------------------
K
A
D
P
S
H
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
K
V
T
R
---
P
D
---
S
G
H
L
Y
A
M
K
V
L
-----------------------
I
L
A
-
D
V
-
N
H
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
---------------
G
T
V
E
Y
M
A
P
E
V
V
N
R
Q
G
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
L
P
F
Q
G
K
D
R
K
E
----
T
M
T
L
I
L
K
A
K
L
G
M
P
Q
F
--
L
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
R
L
----
G
----
S
GPD
G
-
A
-----
E
E
----
I
---
K
R
H
V
F
Y
S
T
I
D
W
N
K
L
Y
R
R
E
I
K
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
50.04
42%
23
- C1 -
-
2Z7R
1
KS6A1_HUMAN
A:
[21-308]
------------------------------------------------------------------------------------------------
G
S
E
K
A
D
P
S
H
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
K
V
T
R
---
P
D
---
S
G
H
L
Y
A
M
K
V
L
K
-
K
A
T
-
L
K
V
--------------
I
L
A
-
D
V
-
N
H
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
---------------
G
T
V
E
Y
M
A
P
E
V
V
N
R
Q
G
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
L
P
F
Q
G
K
D
R
K
E
----
T
M
T
L
I
L
K
A
K
L
G
M
P
Q
F
--
L
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
R
L
----
G
----
S
GPDG-
A
-----
E
E
----
I
---
K
R
H
V
F
Y
S
T
I
D
W
N
K
L
Y
R
R
E
I
K
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
48.38
44%
19
- C1 -
-
3A61
1
KS6B1_HUMAN
A:
[15-299]
-----------------------------------------------------------------------------------------------------
R
P
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
---
R
K
V
T
G
A
N
---
T
G
K
I
F
A
M
K
V
L
K
------------------
A
E
R
N
I
L
E
-
E
V
-
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
-------------------
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
R
K
K
----
T
I
D
K
I
L
K
C
K
L
N
L
P
P
Y
--
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
----
G
----
A
-----
G
-----
P
G
D
A
G
E
V
---
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------------------------------------------