@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_30_1780: (2018-03-11 )
MAHLFFTGACAAAAVLPTSDREEVSPVWSIYDDYCCSASQNAEVNDPQVEGGGVGNCGGTALPRLPLISGPVPSMTLKGAQLKKEAPIRRGAQGAVYSALDVATSAPAEDENAKGLFSQEACRGHDGEEQVADGGQRPARRGRRVAVKRIFIQASDFGARDISATVLREVTLHRFVSEKQAACLAAAGTSYSTASASDATARAEDDQGQALCNLIDDSARVIHLYRVVEAPHKEMCLVMELAATNLEQVVFPHGARGAQRGDGAGGYMRKPGVVSLFGSSASIGVGGGLGLSSASLSTAPDAATADAGPQASPPSPPPSRMPLVRYVMRRLLRLVCFLHETCRVVHRDLKLSNVLVSKDAGLRLGDFGSARFIPPLRSATKTGCENSPSVLKPPAAPAGQREHLLCTPPSIRTTLHYRPPEALLGDQVCRTAADVWALGVIFAQLLLQKGLFRSESELDLLGGIQKLLGMPTYSAPPSWLGAPPVPGPPRDRESAAHIPAPQASLPYKFHAGVVPADGLDLLSRMLHQQPECRITAREALQHPFLNLEGLSALATHDDDERGRVLWEERVATVLREQATGPIYGMGRGERRPMLISLADNEDEEDQEDDEDGAAPFCVDLGGCTSY
Atome Classification :
(21 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.....---..160.......170....-...180.......190.......200.......210.......220.......230----.-----.......240..-.....250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350....--.-.--.--360-.--........370........380.......390.......400.......410.......420...-----....430.......440.......450.......460.......470.......480...---..-----..490.---------.--.-----.--------...500.......510.......520.......530.......540.......550.......560.......---570.......580.......590.......600.......610.......620....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
A
H
L
F
FTGA
C
A
A
A
A
VLPTS
D
R
EEV
S
P
V
W
S
I
Y
D
D
YCCSASQNAEVNDPQVEGGGVGNCGGTALPRLPLISGPVPSMTLKGAQLKKEAPIRRGAQG
A
V
Y
S
A
L
D
VATSAPAEDENAKGL
F
S
Q
E
ACRGHDG
E
E
Q
V
ADGGQR
P
A
RRG
R
R
V
A
V
K
R
I
F
I
QASDF---GAR
D
I
S
A
T
V
L
R
E
V
T
L
H
R
F
V
-
S
E
K
Q
A
A
C
LAAAGTSYSTASASDATARAEDD
Q
G
Q
A
L
C
N
L
IDDS
A
R
V
I
H
L
Y
R
V
VEAP-----
H
-----
K
E
M
C
L
V
M
E
L
A
AT-
N
L
E
Q
VVFPHGARGAQRGDGAGGYMRKP
G
V
V
S
L
FGSSASIGVGGGLGLSSASLSTAPDAATADAGPQASPPSPPPSR
M
P
L
V
R
Y
V
M
R
R
L
L
R
L
V
C
F
L
H
E
T
C
R
V
V
H
R
DLK
L
S
N
V
L
V--S-K--D--A---G--LRLGDFGSAR-FIPP
L
R
S
A
T
KTGCENSPSVLKPPAAPAGQR
E
H
L
L
CTPPS
I
R
T
T
L
HYR
P
P
E
A
L
L
G
-----
D
Q
V
C
R
T
A
A
D
V
W
A
L
G
V
I
F
A
Q
L
L
L
Q
KGLFRSES
E
L
D
L
L
G
G
I
Q
K
L
LGMPTYSAPPSWLGAPPV---PG-----PPRDRE---------S--A-----A--------HIPAPQASLP
Y
K
FHAGVVPAD
G
L
D
L
L
S
R
M
L
HQQPE
C
R
I
T
A
R
E
A
L
QHPFLNLEG
L
S
A
LATHDDDERGR
V
L
W
E
E
R
---
V
A
T
V
L
R
E
QATGPIYGMGRGERR
P
M
L
I
S
LADNEDEEDQEDDEDGAA
P
F
C
V
DLGGCTSY
47
HHSearch
82.43
26%
-84
- C1 -
-
5LXC
9
DYRK2_HUMAN
A:
[74-392]
-----------------------------------------------------------------------------
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
H
K
-------------------------------------
V
H
Q
H
V
A
L
K
M
V
R
N
E
K
R
---------
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
-
R
K
Q
D
----------------------------------
K
D
N
T
M
N
V
I
H
M
L
E
N
F
T
F
R
-----------
N
H
I
C
M
T
F
E
L
L
S
M
-
N
L
Y
E
L
I
K
K
N
K
F
-------------------------------------------------------------
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
H
K
-
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
--
K
-
Q
--
Q
--
G
---
R
S
G
I
K
V
I
D
F
G
S
S
C
-
Y
E
H
Q
R
-----------------------------
V
--
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
-----
A
-
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
D
A
S
K
R
A
K
N
F
VSS
K
G
-----
Y
P
R
Y
C
T
V
T
T
LSD
G
S
V
V
L
N
G
G
R
SRR
G
K
L
------
R
G
P
P
E
S
R
E
W
G
N
A
L
-
K
G
C
D
D
P
L
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
-----------------------------------------------------------------------------------
34
HHSearch
82.06
27%
-90
- C1 -
-
4AZF
2
DYRK2_HUMAN
A:
[96-413]
------------------------------------------------------------------------------
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
H
K
-------------------------------------
V
H
Q
H
V
A
L
K
M
V
R
N
E
K
R
---------
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
-
R
K
Q
D
----------------------------------
K
D
N
T
M
N
V
I
H
M
L
E
N
F
T
F
R
-----------
N
H
I
C
M
T
F
E
L
L
S
M
-
N
L
Y
E
L
I
K
K
N
K
F
-------------------------------------------------------------
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
H
K
-
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
--
K
-
Q
--
Q
--
G
---
R
S
G
I
K
V
I
D
F
G
S
S
C
-
Y
E
H
Q
R
-----------------------------
V
--
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
-----
A
-
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
D
A
S
K
R
A
K
N
F
VSS
K
G
-----
Y
P
R
Y
C
T
V
T
TLS
D
V
--
V
--
L
N
----
G
G
RSR
R
G
K
L
R
G
P
P
E
S
R
E
W
G
N
A
L
-
K
G
C
D
D
P
L
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
-----------------------------------------------------------------------------------
26
HHSearch
79.61
28%
-119
- C1 -
-
1UA2
1
CDK7_HUMAN
D:
[13-300]
----------------------------------------------------------------------------------
E
K
L
D
F
L
G
E
G
Q
F
A
T
V
Y
K
A
R
D
K
N
-------------------------------------
T
N
Q
I
V
A
I
K
K
I
---------------
N
R
T
A
L
R
E
I
K
L
L
Q
E
L
-
S
H
----------------------------------------
P
N
I
I
G
L
L
D
A
F
G
H
K
-----------
S
N
I
S
L
V
F
D
F
M
E
T
-
D
L
E
V
I
I
K
D
N
S
--------------------------------------------------------------
L
V
L
T
P
S
H
I
K
A
Y
M
L
M
T
L
Q
G
L
E
Y
L
H
Q
-
H
W
I
L
H
R
D
L
K
P
N
N
L
L
L
--
D
-
E
--
N
--
G
---
V
--
L
K
L
A
D
F
G
L
A
K
-
S
F
G
S
P
N
R
--
A
------------------------
Y
--
T
H
Q
V
V
T
R
W
Y
R
A
P
E
L
L
F
G
-----
A
R
M
Y
G
V
G
V
D
M
W
A
V
G
C
I
L
A
E
L
L
L
R
V
P
F
L
P
G
D
S
D
L
D
Q
L
T
R
I
F
E
T
L
G
T
P
T
E
---
E
Q
W
P
D
M
C
S
L
---
P
D
-----
Y
V
T
---------------
F
---------------
K
S
F
P
G
I
P
L
H
H
I
F
--
S
A
A
G
D
D
L
L
D
L
I
Q
G
L
F
L
F
N
P
C
A
R
I
T
A
T
Q
A
L
K
M
K
Y
F
S
N
R
P
G
-------------------------------------------------------------------------------
39
HHSearch
70.37
27%
0
- C- -
-
3EB0
3
?
A:
[6-348]
------------------------------------------------------------------------------
S
K
K
Y
S
L
G
K
T
L
G
T
G
-
F
G
I
V
C
E
V
F
D
I
E
-------------------------------------
S
G
K
R
F
A
L
K
K
V
L
Q
D
P
R
------------
Y
K
N
R
E
L
D
I
M
K
V
L
-
D
H
----------------------------------------
V
N
I
I
K
L
V
D
Y
F
Y
T
T
-----
N
-----
K
Y
L
N
V
I
M
E
Y
V
P
D
-
T
L
H
K
V
L
K
S
F
I
R
S
-----------------------------------------------------------
G
R
S
I
P
M
N
L
I
S
I
Y
I
Y
Q
L
F
R
A
V
G
F
I
H
S
-
L
G
I
C
H
R
D
I
K
P
Q
N
L
L
V
--
N
S
K
--
D
--
N
---
T
--
L
K
L
C
D
F
G
S
A
K
-
K
L
I
P
S
E
---
P
------------------------
S
--
V
A
Y
I
C
S
R
F
Y
R
A
P
E
L
M
L
G
-----
A
T
E
Y
T
P
S
I
D
L
W
S
I
G
C
V
F
G
E
L
I
L
G
K
P
L
F
S
G
E
T
S
I
D
Q
L
V
R
I
I
Q
I
M
G
T
P
T
K
E
Q
---
M
I
R
--------
M
-----
N
P
H
Y
-----------
V
--
R
-----
F
---------
P
T
L
K
A
K
D
W
R
K
I
L
-
P
E
G
T
P
S
L
A
I
D
L
L
E
Q
I
L
R
Y
E
P
D
L
R
I
N
P
Y
E
A
M
A
H
P
F
F
D
H
L
R
N
-------------------------------------------------------------------------------
25
HHSearch
68.87
29%
-27
- C1 -
-
5BYZ
7
MK07_HUMAN
A:
[4-305]
-----------------------------------------------------------------------------
V
G
D
E
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
R
L
-------------------------------------
T
G
Q
Q
V
A
I
K
K
I
P
N
A
F
D
V
------
V
T
N
A
K
R
T
L
R
E
L
K
I
L
K
H
F
-
K
H
----------------------------------------
D
N
I
I
A
I
K
D
I
L
R
P
T
VPYGE
F
-----
K
S
V
Y
V
V
L
D
L
M
E
S
-
D
L
H
Q
I
I
H
S
S
Q
---------------------------------------------------------------
P
L
T
L
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
-
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
--
N
-
E
--
N
--
C
---
E
--
L
K
I
G
D
F
G
M
A
R
-
G
L
C
T
S
P
A
E
H
Q
------------------------
Y
F
M
T
E
Y
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
-----
L
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
R
R
Q
L
F
P
G
K
N
Y
V
H
Q
L
Q
L
I
M
M
V
L
G
T
P
S
P
A
V
I
Q
A
V
G
A
-------
E
R
-----
V
R
A
Y
I
Q
---------
S
--
L
---------------
P
P
R
Q
P
V
P
W
E
-
T
V
-
Y
P
G
A
D
R
Q
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
Y
H
D
-------------------------------------------------------------------------------
21
HHSearch
66.26
25%
-46
- C1 -
-
1J1B
1
GSK3B_HUMAN
B:
[47-345]
------------------------------------------------------------------------
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
-------------------------------------
S
G
E
L
V
A
I
K
K
V
L
Q
D
K
------------
R
F
K
N
R
E
L
Q
I
M
R
K
L
-
D
H
----------------------------------------
C
N
I
V
R
L
R
Y
F
F
Y
S
S
-----
G
EKKD
E
V
Y
L
N
L
V
L
D
Y
V
P
E
-
T
V
Y
R
V
A
R
H
Y
S
R
A
-----------------------------------------------------------
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
-
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
--
D
-
P
--
D
T-
A
---
V
--
L
K
L
C
D
F
G
S
A
K
-
Q
L
V
R
G
E
P
---------------------------
N
--
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
-----
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
N
Y
-------------
T
E
F
-----------
K
--
F
---------------
P
Q
I
K
A
H
P
W
T
K
V
F
-
R
P
R
T
P
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
-------------------------------------------------------------------------------
43
HHSearch
61.95
29%
-30
- C1 -
-
2Y7J
1
PHKG2_HUMAN
C:
[93-364]
------------------------------------------------------------------------------
Y
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
-------------------------------------
T
G
H
E
F
A
V
K
I
M
E
V
T
A
E
R
L
SPE
Q
L
E
E
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
A
G
H
----------------------------------------
P
H
I
I
T
L
I
D
S
Y
E
S
S
-----------
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
V
---------------------------------------------------------------
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
-
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
--
D
-
D
--
N
--
M
---
Q
--
I
R
L
S
D
F
G
F
S
C
-
H
L
E
P
G
E
K
---------------------------
L
--
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
C
SMDET
H
P
G
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
R
R
Q
I
L
M
L
R
M
I
M
E
G
--
Q
Y
Q
---------------------------------------------------------
F
S
-----
S
-
P
E
--
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
A
E
Q
A
L
Q
H
P
F
F
E
-----------------------------------------------------------------------------------
27
HHSearch
55.57
23%
-73
* C1 *
-
3C0G
1
CSKP_HUMAN
B:
[19-296]
--------------------------------------------------------------------------
D
V
L
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
-------------------------------------
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
---
S
P
G
L
S
T
E
D
L
K
R
E
A
S
I
C
H
M
L
-
K
H
----------------------------------------
P
H
I
V
E
L
L
E
T
Y
S
S
D
-----------
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
A
-----------------------------------------------------------
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
-
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
--
A
-
S
--
K
--
E
NS
A
P
--
V
K
L
G
G
F
G
V
A
I
-
Q
L
G
E
S
G
L
--
V
------------------------
A
--
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
R
-----
E
-
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
K
E
R
-
L
F
E
G
I
I
K
G
K
----------
Y
K
-------------------------------------------------
M
------
N
P
R
Q
W
--
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
R
Y
------------------------------------------------------------------------------
46
HHSearch
54.55
23%
-50
- C1 -
-
2BDW
-
KCC2D_CAEEL
A:
[8-276]
----------------------------------------------------------------------------
K
F
S
D
N
Y
D
V
K
E
E
L
G
K
G
A
F
S
V
V
R
R
C
V
H
K
T
-------------------------------------
T
G
L
E
F
A
A
K
I
I
N
T
K
K
L
S
------
A
R
D
F
Q
K
L
E
R
E
A
R
I
C
R
K
L
-
Q
H
----------------------------------------
P
N
I
V
R
L
H
D
S
I
Q
E
E
-----------
S
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
---------------------------------------------------------------
F
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
I
A
Y
C
H
S
-
N
G
I
V
H
R
N
L
K
P
E
N
L
L
L
--
A
-
S
--
K
--
A
KG
A
A
--
V
K
L
A
D
F
G
L
A
I
-
E
V
N
D
S
E
A
---------------------------
W
--
H
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
K
K
-----
D
-
P
Y
S
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
H
R
L
Y
A
Q
I
K
A
G
A
Y
D
Y
-----------------------------------------------------------
P
S
---
P
E
-----
W
D
T
V
T
P
E
A
K
S
L
I
D
S
M
L
T
V
N
P
K
K
R
I
T
A
D
Q
A
L
K
V
P
W
I
C
N
R
E
R
-------------------------------------------------------------------------------
36
HHSearch
54.18
25%
-64
- C1 -
-
4XBR
1
INKA1_HUMAN (first)
A:
[93-352]
------------------------------------------------------------------------------
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
-------------------------------------
S
G
K
L
V
A
V
K
K
M
D
L
R
K
Q
Q
--------
R
R
E
L
L
F
N
E
V
V
I
M
R
D
Y
-
Q
H
----------------------------------------
E
N
V
V
E
M
Y
N
S
Y
L
V
G
-----------
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
T
----------------------------------------------------------------
R
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
-
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
--
T
-
H
--
D
--
G
---
R
--
V
K
L
S
D
F
G
F
C
A
-
Q
V
S
K
E
V
P
--
R
------------------------
R
--
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
R
-----
L
-
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
--
P
P
---------------------------------------------------------------
R
L
K
-
N
L
--
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
A
K
A
G
P
-------------------------------------------------------------------------------
32
HHSearch
54.10
23%
-70
- C1 -
-
3C0I
1
CSKP_HUMAN
A:
[20-296]
---------------------------------------------------------------------------
V
L
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
-------------------------------------
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
---
S
P
G
L
S
T
E
D
L
K
R
E
A
S
I
C
H
M
L
-
K
H
----------------------------------------
P
H
I
V
E
L
L
E
T
Y
S
S
D
-----------
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
A
G
-----------------------------------------------------------
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
-
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
--
A
-
S
--
K
--
E
NS
A
P
--
V
K
L
G
G
F
G
V
A
I
-
Q
L
G
E
S
G
L
----------------------------
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
R
-----
E
-
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
K
E
R
-
L
F
E
G
I
I
K
G
K
----------
Y
K
-------------------------------------------------
M
------
N
P
R
Q
--
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
R
Y
------------------------------------------------------------------------------
29
HHSearch
54.04
22%
-85
- C1 -
-
5K00
1
MELK_HUMAN
A:
[8-267]
-------------------------------------------------------------------------------
K
Y
Y
E
L
H
E
T
I
G
T
G
--
A
K
V
K
L
A
C
H
I
L
-------------------------------------
T
G
E
M
V
A
I
K
I
M
D
K
N
T
L
G
-------
S
D
L
P
R
I
K
T
E
I
E
A
L
K
N
L
-
R
H
----------------------------------------
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
-----------
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
---------------------------------------------------------------
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
-
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
--
D
-
E
--
Y
--
H
---
K
--
L
K
L
I
D
F
G
L
C
A
-
K
P
----------------------------------------
S
L
A
Y
A
A
P
E
L
I
Q
G
-----
K
S
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
--
K
-----------------------------------------------------------
Y
-----
D
V
P
-----
K
W
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
L
L
N
H
P
W
I
M
Q
D
Y
N
-------------------------------------------------------------------------------
45
HHSearch
53.99
23%
-51
- C1 -
-
1KOB
1
?
A:
[50-313]
------------------------------------------------------------------------------
Y
D
Y
Y
D
I
L
E
E
L
G
S
G
A
F
G
V
V
H
R
C
V
E
K
A
-------------------------------------
T
G
R
V
F
V
A
K
F
I
N
T
P
Y
P
L
--------
D
K
Y
T
V
K
N
E
I
S
I
M
N
Q
L
-
H
H
----------------------------------------
P
K
L
I
N
L
H
D
A
F
E
D
K
-----------
Y
E
M
V
L
I
L
E
F
L
S
G
G
E
L
F
D
R
I
A
A
E
D
--------------------------------------------------------------
Y
K
M
S
E
A
E
V
I
N
Y
M
R
Q
A
C
E
G
L
K
H
M
H
E
-
H
S
I
V
H
L
D
I
K
P
E
N
I
M
C
--
E
-
T
--
K
KA
S
---
S
--
V
K
I
I
D
F
G
L
A
T
-
K
L
N
P
D
E
I
---------------------------
V
--
K
V
T
T
A
T
A
E
F
A
A
P
E
I
V
D
R
-----
E
-
P
V
G
F
Y
T
D
M
W
A
I
G
V
L
G
Y
V
L
L
S
G
L
S
P
F
A
G
E
D
D
L
E
T
L
Q
N
V
K
R
C
D
----------
W
E
-------------------------------------------------
F
D
E
---
D
A
-----
F
S
S
V
S
P
E
A
K
D
F
I
K
N
L
L
Q
K
E
P
R
K
R
L
T
V
H
D
A
L
E
H
P
W
L
K
G
D
H
S
-------------------------------------------------------------------------------
5
PsiBlast_PDB
53.34
32%
-103
- C1 -
-
3EZV
1
CDK2_HUMAN
A:
[103-289]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
-
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
-
T
--
E
--
G
---
A
--
I
K
L
A
D
F
G
L
--------------
V
V
-----------------------------
T
L
W
Y
R
A
P
E
I
L
L
G
-----
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
---
W
P
G
V
T
S
M
---
P
D
YKPSF
P
K
W
A
R
Q
---------
D
--
F
-----
S
--------
K
V
V
P
P
------------
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------
2
PsiBlast_PDB
52.98
32%
-109
- C1 -
-
1GIJ
1
CDK2_HUMAN
A:
[101-287]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
-
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
-
T
--
E
--
G
---
A
--
I
K
L
A
D
F
G
L
A
--------------
V
-----------------------------
T
L
W
Y
R
A
P
E
I
L
L
G
-----
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
---
W
P
G
V
T
S
M
---
P
D
YKPSF
P
K
W
A
R
Q
---------
D
--
F
-----
S
--------
K
V
V
P
P
------------
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------
4
PsiBlast_PDB
52.59
32%
-113
- C1 -
-
3EZR
1
CDK2_HUMAN
A:
[103-289]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
-
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
-
T
--
E
--
G
---
A
--
I
K
L
A
D
F
-----------------------------------------------
T
L
W
Y
R
A
P
E
I
L
L
G
-----
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
---
W
P
G
V
T
S
M
---
P
D
YKPSF
P
K
W
A
R
Q
---------
D
--
F
-----
S
--------
K
V
V
P
P
------------
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------
49
Fugue
51.69
19%
-32
- C1 -
-
1TKI
-
TITIN_HUMAN
A:
[18-338]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
L
Y
E
K
Y
M
I
A
E
D
L
G
R
G
E
F
G
I
V
H
R
C
V
E
T
S
-----
S
-----
K
K
T
Y
M
A
K
F
V
K
V
K
-
G
T
D
Q
V
L
V
K
K
E
I
S
I
L
N
I
-------
A
R
H
R
N
I
L
H
L
H
E
S
F
E
S
---------
M
E
E
L
V
M
I
F
E
F
I
S
G
L
D
I
F
E
R
I
N
T
S
A
F
E
L
N
E
R
E
I
V
S
Y
-
V
H
Q
V
C
E
A
L
Q
F
L
H
S
H
-
N
I
G
H
F
D
I
R
P
E
N
I
I
Y
QT
R
-
R
--
S
--
S
---
T
--
I
K
I
I
E
F
G
Q
A
R
-
Q
L
K
P
-----------------------
G
D
N
F
R
L
L
F
T
------
A
P
E
Y
Y
A
P
E
V
H
Q
H
-----
D
V
V
-
S
T
A
T
D
M
W
S
L
G
T
L
V
Y
V
L
L
S
G
I
N
P
F
L
A
E
T
N
Q
Q
I
I
E
N
I
M
N
-----------------------------------------------------
A
--------
E
Y
T
F
D
E
E
A
F
K
E
------
I
S
I
E
A
M
D
F
V
D
R
L
L
V
K
E
R
K
S
R
M
T
A
S
E
A
L
Q
H
P
W
L
K
Q
K
I
E
R
V
S
T
K
V
I
R
T
L
K
H
R
R
Y
Y
H
T
L
IKK
D
L
N
M
V
V
S
A
A
R
I
S
C
G
G
A
I
R
S
Q
K
G
V
S
V
A
K
V
K
V
A
S
I
------------------------
22
HHSearch
50.74
21%
-38
- C1 -
-
1TKI
-
TITIN_HUMAN
A:
[21-283]
------------------------------------------------------------------------------
Y
E
K
Y
M
I
A
E
D
L
G
R
G
E
F
G
I
V
H
R
C
V
E
T
S
-------------------------------------
S
K
K
T
Y
M
A
K
F
V
K
V
K
G
T
---------
D
Q
V
L
V
K
K
E
I
S
I
L
N
I
A
-
R
H
----------------------------------------
R
N
I
L
H
L
H
E
S
F
E
S
M
-----------
E
E
L
V
M
I
F
E
F
I
S
G
L
D
I
F
E
R
I
N
T
S
A
--------------------------------------------------------------
F
E
L
N
E
R
E
I
V
S
Y
V
H
Q
V
C
E
A
L
Q
F
L
H
S
-
H
N
I
G
H
F
D
I
R
P
E
N
I
I
Y
--
Q
-
T
RR
S
--
S
---
T
--
I
K
I
I
E
F
G
Q
A
R
-
Q
L
K
P
G
D
N
---------------------------
F
--
R
L
L
F
T
A
P
E
Y
Y
A
P
E
V
H
Q
H
-----
D
-
V
V
S
T
A
T
D
M
W
S
L
G
T
L
V
Y
V
L
L
S
G
I
N
P
F
L
A
E
T
N
Q
Q
I
I
E
N
I
M
N
A
E
Y
T
F
D
-------------------------------------------------------------
E
-
E
---
A
F
--
K
E
I
S
I
E
A
M
D
F
V
D
R
L
L
V
K
E
R
K
S
R
M
T
A
S
E
A
L
Q
H
P
W
L
K
Q
K
I
E
-------------------------------------------------------------------------------
15
PsiBlast_PDB
50.54
32%
-79
- C1 -
-
1OIT
1
CDK2_HUMAN
A:
[101-287]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
S
F
C
H
-
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
-
T
--
E
--
G
---
A
--
I
K
L
A
D
F
G
L
A
R
A-----------
V
V
-----------------------------
T
L
W
Y
R
A
P
E
I
L
L
G
-----
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
---
W
P
G
V
T
S
M
---
P
D
YKPSF
P
K
W
A
R
Q
---------
D
--
F
-----
S
--------
K
V
V
P
P
------------
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------
3
PsiBlast_PDB
50.52
32%
-73
- C1 -
-
2DS1
-
CDK2_HUMAN
A:
[101-287]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
-
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
-
T
--
E
--
G
---
A
--
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
E
V
V
-----------------------------
T
L
W
Y
R
A
P
E
I
L
L
G
-----
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
---
W
P
G
V
T
S
M
---
P
D
YKPSF
P
K
W
A
R
Q
---------
D
--
F
-----
S
--------
K
V
V
P
P
------------
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------
12
PsiBlast_PDB
19.40
32%
-29
- C1 -
-
1H01
3
CDK2_HUMAN
A:
[103-287]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
-
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
-
T
--
E
--
G
---
A
--
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
E
V
V
-----------------------------
T
L
W
Y
R
A
P
E
I
L
L
G
-----
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
---
W
P
G
V
T
S
M
---
P
D
YKPSF
P
K
W
A
R
Q
---------
D
--
F
-----
S
--------
K
V
V
P
P
------------
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------