@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_30_3640: (2018-03-11 )
MGKSKKHGKPVKGASKKGSKHDKSKRKAKFIDPTSSVSRDVRETVAALVQEIEREEPVAEEKLQPLKKGKKCQEIAEKEGILVKTGMTKEQAHTIANRLKQQQSTTHRSDGEGDVGSDGGGDGDGGGTEEDYSDTANEPSREYRKGGYHHVVIGEVYNDRYRVVKKLGWGYFSTVWLVWDYQKERYQAMKIQKSAASYSEAAYDEIKLLSEIMEADPHKNRCCARLNDYFKHTGPNGTHVCMLFDVYGENLLSLMERYEYRGIPLPIVKCIARQVLIGLDHINSIDIIHTDLKPENVLLSTPKHSIISLMKHFHPPPLHQRPKLTERDPKTMTKSQRRRYYKKLAKEERKTLLGEDDGDHKSRGDEHGSNENGDADSEGSKTDPEWEVERFHHVILADFGNSCWTHKQFTDEVQTRQYRCPEVILGEPYSTPIDIWSCACMIFELITGQFLFDPKKGDDYSRDEDHLALMSELLGDLPESMRLGDGKYRSYYYNSKGDLRNIKDLQYWVLEDVLHQRHKFTKKKAKEIADFLLPMLEYAPDTRATPAAMLRDHDAFFDIQDDDYAPLCFVDEDSGDEEGSASDEEEEETDSDDSSQSYSSAPSSELTAKRSRQPDNDADRSDTFRYWEEHPILNRTYLEERGLTIADIQSVLAGNFLDDAAAHEAAAEVIRLLSEETDRLSNDHGSDGHEADNEDGGDGDNDDEEETTQGSEGPEKVVVGKAAPCDDGVDEDEETTDEEEEGSSDGAE
Atome Classification :
(23 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150......-..160.......170.......180-...-.-....190.......200.......210....-----.-----.--.220........230.......240.......250.......260........270.......280--..-.-....290.......300.......310.......320.......330--.........340.......350.......360.......370.......380.......390.......400......-.410.......420.......430.......440.......450.......460.......470.......480.......-490...----..--------..-----------500-------..------------.----...-.-----.--510.--...-----------..---..520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MGKSKKHGKPVKGASKKGSKHDKSKRKAKFIDP
T
S
S
V
S
R
D
V
R
E
T
V
A
A
L
V
Q
E
I
E
REEP
V
A
E
E
K
L
Q
P
L
K
K
G
K
K
C
Q
E
I
A
E
KE
G
I
L
V
KTGM
T
K
E
Q
A
H
T
I
A
N
R
L
K
Q
Q
QSTTHRSDGEGDVGSDGGGDGDGGGTEEDYSDTANEP
S
R
E
Y
RKGGY
H
H
-
V
V
I
G
E
VY-N
D
R
Y
R
V
V
K
K
LGWG
Y
F
S
T
V
W
L
V
WD-Y-
Q
K
E
-
R
-
Y
Q
A
M
K
I
Q
K
S
AASY
S
E
A
A
Y
D
E
I
K
L
L
S
E
I
M
EAD-----P-----H--
K
N
R
-
C
C
A
R
L
N
D
Y
F
KHTGPNG
T
H
V
C
M
L
F
D
V
Y
G
E
N
L
L
S
L
M
E
R
YEY-RGI
P
L
P
I
V
K
C
I
A
R
Q
V
L
I
GLDHI--NS-
I
-
D
I
I
HTDLKPE
N
V
L
LSTP
K
H
S
I
I
S
L
M
K
HFHPPPLHQRPKLTERD
P
K
----
T
M
T
K
S
Q
R
R
R
Y
Y
K
K
L
A
K
E
E
R
K
T
LLGEDDGDHKSRGDEHGSNENGDADSEGSKTDP
E
W
E
V
E
R
F
H
H
V
I
L
A
DFGNSCWTH
K
Q
-
F
T
D
E
V
Q
TRQYRCPE
V
I
LGEPYST
P
I
D
I
W
S
C
A
C
M
I
F
E
L
ITG
Q
F
L
FDPKKGDDYSR
D
E
D
H
L
A
L
M
S
E
L
L
G
D
L
P
E
SMRLGDG
K
Y
R
-
S
Y
Y
YNS----KG--------DL-----------R
N
--------
I
K
------------
D
----
L
Q
Y
-
W
-----
V
--
L
-
E
D
--
V
L
H
-----------
Q
R
---
H
K
F
T
K
K
K
A
K
E
I
A
D
F
L
L
P
M
L
EYAPDTRA
T
P
A
A
M
LRDHD
A
F
F
DIQDDDYA
P
L
C
F
V
DEDSGDEEGSASDEEEEETDSDDSSQSYSSAPS
S
E
L
T
A
KRSRQPDNDADR
S
D
T
F
R
Y
W
E
EHPI
L
N
R
T
Y
L
E
ERG
L
T
I
A
D
I
Q
S
V
L
AGNFL
D
D
A
A
A
H
E
A
A
A
E
V
I
R
L
L
S
E
E
T
D
RLSNDHGSDGHEADNEDGGDGDNDDEEETTQGSEGP
E
K
V
V
VGKAAPCDDGVDEDEETTDEEEEGSSDGAE
3
PsiBlast_PDB
91.81
42%
0
- C- -
-
3BEG
-
A:
[12--7]
-----------------------------------------------------------------------------------------------------------------------------------------------------
L
-
V
K
I
G
D
L
F
-
N
G
R
Y
H
V
I
R
K
L
G
W
G
H
F
S
T
V
W
L
S
W
D
-
I
-
Q
G
K
-
K
-
F
V
A
M
K
V
V
K
S
A
E
H
Y
T
E
T
A
L
D
E
I
R
L
L
K
S
V
R
N
S
D
-----
P
-----
N
D-
P
N
R
E
M
V
V
Q
L
L
D
D
F
K
I
S
G
V
N
G
T
H
I
C
M
V
F
E
V
L
G
H
H
L
L
K
W
I
I
K
S
N
Y
-
Q
G
L
P
L
P
C
V
K
K
I
I
Q
Q
V
L
Q
G
L
D
Y
L
--
H
T
K
C
-
R
I
I
H
T
D
I
K
P
E
N
I
L
L
S
V
---------------------------------------
N
E
Q
Y
I
R
R
L
A
A
E
A
-------------------------
A
G
N
F
L
V
N
P
L
E
P
K
-
N
A
E
K
L
-
K
V
K
I
A
D
L
G
N
A
C
W
V
H
K
H
-
F
T
E
D
I
Q
T
R
Q
Y
R
S
L
E
V
L
I
G
S
G
Y
N
T
P
A
D
I
W
S
T
A
C
M
A
F
E
L
A
T
G
D
Y
L
F
E
P
H
S
G
E
E
Y
T
R
D
E
D
H
I
A
L
I
I
E
L
L
G
K
V
P
R
K
L
I
V
A
-
G
K
Y
S
-
K
E
F
F
T
K
----
K
G
--------
D
L
-----------
K
H
--------
I
T
------------
K
----
L
K
P
-
W
-----
G
--
L
-
F
E
--
V
L
V
-----------
E
K
---
Y
E
W
S
Q
E
E
A
A
G
F
T
D
F
L
L
P
M
L
E
L
I
P
E
K
R
A
T
A
A
E
C
L
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
81.71
41%
-36
- C1 -
-
5MYV
2
SRPK2_HUMAN
A:
[20-383]
---------------------------------------------------------------------------------------------------------------------------------------------------
Y
H
P
-
V
K
I
G
D
L
F
-
N
G
R
Y
H
V
I
R
K
L
G
W
G
H
F
S
T
V
W
L
C
W
D
-
M
-
Q
G
K
-
R
-
F
V
A
M
K
V
V
K
S
A
Q
H
Y
T
E
T
A
L
D
E
I
K
L
L
K
C
V
R
E
S
D
-----
P
-----
S
DP
N
K
D
-
M
V
V
Q
L
I
D
D
F
K
I
S
G
M
N
G
I
H
V
C
M
V
F
E
V
L
G
H
H
L
L
K
W
I
I
K
S
N
Y
-
Q
G
L
P
V
R
C
V
K
S
I
I
R
Q
V
L
Q
G
L
D
Y
L
--
H
S
K
C
-
K
I
I
H
T
D
I
K
-----------------------------------
P
E
----
N
I
L
M
C
V
D
D
A
Y
V
R
R
M
A
A
E
A
T
E
---
W
Q
K
--------------------
L
L
V
N
P
L
D
P
R
-
N
A
D
K
I
R
-
V
K
I
A
D
L
G
N
A
C
W
V
H
K
H
-
F
T
E
D
I
Q
T
R
Q
Y
R
S
I
E
V
L
I
G
A
G
Y
S
T
P
A
D
I
W
S
T
A
C
M
A
F
E
L
A
T
G
D
Y
L
F
E
P
H
S
G
E
D
Y
S
R
D
E
D
H
I
A
H
I
I
E
L
L
G
S
I
P
R
H
F
A
L
S
-
G
K
Y
S
-
R
E
F
F
N
R
----
R
G
--------
E
L
-----------
R
H
--------
I
T
------------
K
----
L
K
P
-
W
-----
S
--
L
-
F
D
--
V
L
V
-----------
E
K
---
Y
G
W
P
H
E
D
A
A
Q
F
T
D
F
L
I
P
M
L
E
M
V
P
E
K
R
A
S
A
G
E
C
L
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
81.14
42%
-21
- C1 -
-
5MY8
24
?
A:
[9-377]
------------------------------------------------------------------------------------------------------------------------------------------------
K
G
G
Y
H
L
-
V
K
I
G
D
L
F
-
N
G
R
Y
H
V
I
R
K
L
G
W
G
H
F
S
T
V
W
L
S
W
D
-
I
-
Q
G
K
-
K
-
F
V
A
M
K
V
V
K
S
A
E
H
Y
T
E
T
A
L
D
E
I
R
L
L
K
S
V
R
N
S
D
-----
P
-----
N
D-
P
N
R
E
M
V
V
Q
L
L
D
D
F
K
I
S
G
V
N
G
T
H
I
C
M
V
F
E
V
L
G
H
H
L
L
K
W
I
I
K
S
N
Y
-
Q
G
L
P
L
P
C
V
K
K
I
I
Q
Q
V
L
Q
G
L
D
Y
L
--
H
T
K
C
-
R
I
I
H
T
D
I
K
P
E
N
I
L
L
S
V
---------------------------------------
N
E
Q
Y
I
R
R
L
A
A
E
A
T
E
---
W
Q
R
--------------------
F
L
V
N
P
L
E
P
K
-
N
A
E
K
L
-
K
V
K
I
A
D
L
G
N
A
C
W
V
H
K
H
-
F
T
E
D
I
Q
T
R
Q
Y
R
S
L
E
V
L
I
G
S
G
Y
N
T
P
A
D
I
W
S
T
A
C
M
A
F
E
L
A
T
G
D
Y
L
F
E
P
H
S
G
E
E
Y
T
R
D
E
D
H
I
A
L
I
I
E
L
L
G
K
V
P
R
K
L
I
V
A
-
G
K
Y
S
-
K
E
F
F
T
K
----
K
G
--------
D
L
-----------
K
H
--------
I
T
------------
K
----
L
K
P
-
W
-----
G
--
L
-
F
E
--
V
L
V
-----------
E
K
---
Y
E
W
S
Q
E
E
A
A
G
F
T
D
F
L
L
P
M
L
E
L
I
P
E
K
R
A
T
A
A
E
C
L
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
80.46
42%
-18
- C1 -
-
1WAK
5
SRPK1_HUMAN
A:
[22-391]
-----------------------------------------------------------------------------------------------------------------------------------------------
C
K
--
Y
H
L
-
V
K
I
G
D
L
F
-
N
G
R
Y
H
V
I
R
K
L
G
W
G
H
F
S
T
V
W
L
S
W
D
-
I
-
Q
G
K
-
K
-
F
V
A
M
K
V
V
K
S
A
E
H
Y
T
E
T
A
L
D
E
I
R
L
L
K
S
V
R
N
S
D
-----
P
-----
N
D-
P
N
R
E
M
V
V
Q
L
L
D
D
F
K
I
S
G
V
N
G
T
H
I
C
M
V
F
E
V
L
G
H
H
L
L
K
W
I
I
K
S
N
Y
-
Q
G
L
P
L
P
C
V
K
K
I
I
Q
Q
V
L
Q
G
L
D
Y
L
--
H
T
K
C
-
R
I
I
H
T
D
I
K
P
E
N
I
L
L
S
V
---------------------------------------
N
E
Q
Y
I
R
R
L
A
A
E
A
------------------------
T
A
G
N
F
L
V
N
P
L
E
P
K
-
N
A
E
K
L
-
K
V
K
I
A
D
L
G
N
A
C
W
V
H
K
H
-
F
T
E
D
I
Q
T
R
Q
Y
R
S
L
E
V
L
I
G
S
G
Y
N
T
P
A
D
I
W
S
T
A
C
M
A
F
E
L
A
T
G
D
Y
L
F
E
P
H
S
G
E
E
Y
T
R
D
E
D
H
I
A
L
I
I
E
L
L
G
K
V
P
R
K
L
I
V
A
-
G
K
Y
S
-
K
E
F
F
T
K
----
K
G
--------
D
L
-----------
K
H
--------
I
T
------------
K
----
L
K
P
-
W
-----
G
--
L
-
F
E
--
V
L
V
-----------
E
K
---
Y
E
W
S
Q
E
E
A
A
G
F
T
D
F
L
L
P
M
L
E
L
I
P
E
K
R
A
T
A
A
E
C
L
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
80.07
45%
-23
- C1 -
-
5MY8
24
?
A:
[9-382]
------------------------------------------------------------------------------------------------------------------------------------------------
K
G
G
Y
H
L
-
V
K
I
G
D
L
F
-
N
G
R
Y
H
V
I
R
K
L
G
W
G
H
F
S
T
V
W
L
S
W
D
-
I
-
Q
G
K
-
K
-
F
V
A
M
K
V
V
K
S
A
E
H
Y
T
E
T
A
L
D
E
I
R
L
L
K
S
V
R
N
S
D
-----
P
N----
D
P
-
N
R
E
-
M
V
V
Q
L
L
D
D
F
K
I
S
G
V
N
G
T
H
I
C
M
V
F
E
V
L
G
H
H
L
L
K
W
I
I
K
S
N
Y
-
Q
G
L
P
L
P
C
V
K
K
I
I
Q
Q
V
L
Q
G
L
D
Y
L
--
H
T
-
K
C
R
I
I
H
T
D
I
K
P
E
N
I
L
L
S
V
N
E
Q
Y
I
R
R
L
A
A
E
A
T
E
W
Q
R
----------------------------------------------------------------
F
L
V
N
P
L
E
P
K
N
A
E
K
L
K
V
K
I
A
D
L
G
N
A
C
W
V
H
K
H
-
F
T
E
D
I
Q
T
R
Q
Y
R
S
L
E
V
L
I
G
S
G
Y
N
T
P
A
D
I
W
S
T
A
C
M
A
F
E
L
A
T
G
D
Y
L
F
E
P
H
S
G
E
E
Y
T
R
D
E
D
H
I
A
L
I
I
E
L
L
G
K
V
P
R
K
L
I
V
A
-
G
K
Y
S
-
K
E
F
F
T
K
----
K
G
--------
D
L
-----------
K
H
--------
I
T
------------
K
----
L
K
P
-
W
-----
G
--
L
-
F
E
--
V
L
V
-----------
E
K
---
Y
E
W
S
Q
E
E
A
A
G
F
T
D
F
L
L
P
M
L
E
L
I
P
E
K
R
A
T
A
A
E
C
L
R
H
--
P
W
L
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
79.80
42%
-23
- C1 -
-
4WUA
2
?
A:
[32-395]
-----------------------------------------------------------------------------------------------------------------------------------------------------
L
-
V
K
I
G
D
L
F
-
N
G
R
Y
H
V
I
R
K
L
G
W
G
H
F
S
T
V
W
L
S
W
D
-
I
-
Q
G
K
-
K
-
F
V
A
M
K
V
V
K
S
A
E
H
Y
T
E
T
A
L
D
E
I
R
L
L
K
S
V
R
N
S
D
-----
P
-----
N
D-
P
N
R
E
M
V
V
Q
L
L
D
D
F
K
I
S
G
V
N
G
T
H
I
C
M
V
F
E
V
L
G
H
H
L
L
K
W
I
I
K
S
N
Y
-
Q
G
L
P
L
P
C
V
K
K
I
I
Q
Q
V
L
Q
G
L
D
Y
L
--
H
T
K
C
-
R
I
I
H
T
D
I
K
P
E
N
I
L
L
S
V
---------------------------------------
N
E
Q
Y
I
R
R
L
A
A
E
A
T
-----------------------------
V
N
P
L
E
P
K
-
N
A
E
K
L
-
K
V
K
I
A
D
L
G
N
A
C
W
V
H
K
H
-
F
T
E
D
I
Q
T
R
Q
Y
R
S
L
E
V
L
I
G
S
G
Y
N
T
P
A
D
I
W
S
T
A
C
M
A
F
E
L
A
T
G
D
Y
L
F
E
P
H
S
G
E
E
Y
T
R
D
E
D
H
I
A
L
I
I
E
L
L
G
K
V
P
R
K
L
I
V
A
-
G
K
Y
S
-
K
E
F
F
T
K
----
K
G
--------
D
L
-----------
K
H
--------
I
T
------------
K
----
L
K
P
-
W
-----
G
--
L
-
F
E
--
V
L
V
-----------
E
K
---
Y
E
W
S
Q
E
E
A
A
G
F
T
D
F
L
L
P
M
L
E
L
I
P
E
K
R
A
T
A
A
E
C
L
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
76.09
31%
-106
- C1 -
-
4AZF
2
DYRK2_HUMAN
A:
[96-413]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
H
-
K
V
H
-
Q
-
H
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
-----
K
-----
D
--
N
T
M
-
N
V
I
H
M
L
E
N
F
T
F
----
R
N
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
K
F
-
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
--
H
K
-
N
-
R
I
I
H
C
D
L
K
P
E
N
I
L
L
K
Q
Q
G
R
-------------------------------------------------------------------------------------------
S
G
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
R
-
V
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
------
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
D
A
-
S
K
R
A
-
K
N
F
V
S
S
----
K
G
YP------
R
Y
-----------
C
T
V
T
TLS
D
V
V
L
N
------------
G
----
G
R
S
-
R
R
G
K
L
R
G
--
P
-
P
E
--
S
R
E
-----------
W
G
---
N
A
L
K
G
C
D
D
P
L
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
--
P
W
L
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
75.93
49%
1
- C1 -
-
1Q99
2
SKY1_YEAST
B:
[5-343]
-------------------------------------------------------------------------------------------------------------------------------------------------
G
G
Y
H
P
-
A
F
K
G
E
P
Y
K
D
A
R
Y
I
L
V
R
K
L
G
W
G
H
F
S
T
V
W
L
A
K
D
-
M
-
V
N
N
-
T
-
H
V
A
M
K
I
V
R
G
D
K
V
Y
T
E
A
A
E
D
E
I
K
L
L
Q
R
V
N
D
A
D
-----
N
T
K
E
D
S
M
--
G
A
N
-
H
I
L
K
L
L
D
H
F
N
H
K
G
P
N
G
V
H
V
V
M
V
F
E
V
L
G
E
N
L
L
A
L
I
K
K
Y
E
H
-
R
G
I
P
L
I
Y
V
K
Q
I
S
K
Q
L
L
L
G
L
D
Y
M
--
H
R
-
R
C
G
I
I
H
T
D
I
K
P
E
N
V
L
M
E
I
V
D
S
P
---------------------------------------------------------------------------------------
E
N
L
I
Q
I
K
I
A
D
L
G
N
A
C
W
Y
D
E
H
-
Y
T
N
S
I
Q
T
R
E
Y
R
S
P
E
V
L
L
G
A
P
W
G
C
G
A
D
I
W
S
T
A
C
L
I
F
E
L
I
T
G
D
F
L
F
E
P
D
E
G
H
S
Y
T
K
D
D
D
H
I
A
Q
I
I
E
L
L
G
E
L
P
S
Y
L
L
R
N
-
G
K
Y
T
-
R
T
F
F
N
S
----
R
G
--------
L
L
-----------
R
N
--------
I
S
------------
K
----
L
K
F
-
W
-----
P
--
L
-
E
D
--
V
L
T
-----------
E
K
---
Y
K
F
S
K
D
E
A
K
E
I
S
D
F
L
S
P
M
L
Q
L
D
P
R
K
R
A
D
A
G
G
L
V
N
H
--
P
W
L
K
D
T
L
G
M
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
75.29
41%
-29
- C1 -
-
2X7G
7
SRPK2_HUMAN
A:
[22-383]
-----------------------------------------------------------------------------------------------------------------------------------------------------
P
-
V
K
I
G
D
L
F
-
N
G
R
Y
H
V
I
R
K
L
G
W
G
H
F
S
T
V
W
L
C
W
D
-
M
-
Q
G
K
-
R
-
F
V
A
M
K
V
V
K
S
A
Q
H
Y
T
E
T
A
L
D
E
I
K
L
L
K
C
V
R
E
S
D
-----
P
-----
S
DP
N
K
D
-
M
V
V
Q
L
I
D
D
F
K
I
S
G
M
N
G
I
H
V
C
M
V
F
E
V
L
G
H
H
L
L
K
W
I
I
K
S
N
Y
-
Q
G
L
P
V
R
C
V
K
S
I
I
R
Q
V
L
Q
G
L
D
Y
L
--
H
S
K
C
-
K
I
I
H
T
D
I
K
-----------------------------------
P
E
----
N
I
L
M
C
V
D
D
A
Y
V
R
R
M
A
A
E
-----------------------------
L
L
V
N
P
L
D
P
R
-
N
A
D
K
I
R
-
V
K
I
A
D
L
G
N
A
C
W
V
H
K
H
-
F
T
E
D
I
Q
T
R
Q
Y
R
S
I
E
V
L
I
G
A
G
Y
S
T
P
A
D
I
W
S
T
A
C
M
A
F
E
L
A
T
G
D
Y
L
F
E
P
H
S
G
E
D
Y
S
R
D
E
D
H
I
A
H
I
I
E
L
L
G
S
I
P
R
H
F
A
L
S
-
G
K
Y
S
-
R
E
F
F
N
R
----
R
G
--------
E
L
-----------
R
H
--------
I
T
------------
K
----
L
K
P
-
W
-----
S
--
L
-
F
D
--
V
L
V
-----------
E
K
---
Y
G
W
P
H
E
D
A
A
Q
F
T
D
F
L
I
P
M
L
E
M
V
P
E
K
R
A
S
A
G
E
C
L
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
75.24
49%
2
- C1 -
-
1Q8Y
1
?
B:
[9-343]
-----------------------------------------------------------------------------------------------------------------------------------------------------
P
-
A
F
K
G
E
P
Y
K
D
A
R
Y
I
L
V
R
K
L
G
---
F
S
T
V
W
L
A
K
D
-
M
-
V
N
N
-
T
-
H
V
A
M
K
I
V
R
G
D
K
V
Y
T
E
A
A
E
D
E
I
K
L
L
Q
R
V
N
D
A
D
NT
K
E
D
S
-----
M
--
G
A
N
-
H
I
L
K
L
L
D
H
F
N
H
K
G
P
N
G
V
H
V
V
M
V
F
E
V
L
G
E
N
L
L
A
L
I
K
K
Y
E
H
-
R
G
I
P
L
I
Y
V
K
Q
I
S
K
Q
L
L
L
G
L
D
Y
M
--
H
R
-
R
C
G
I
I
H
T
D
I
K
P
E
N
V
L
M
E
I
V
D
S
P
---------------------------------------------------------------------------------------
E
N
L
I
Q
I
K
I
A
D
L
G
N
A
C
W
Y
D
E
H
-
Y
T
N
S
I
Q
T
R
E
Y
R
S
P
E
V
L
L
G
A
P
W
G
C
G
A
D
I
W
S
T
A
C
L
I
F
E
L
I
T
G
D
F
L
F
E
P
D
E
G
H
S
Y
T
K
D
D
D
H
I
A
Q
I
I
E
L
L
G
E
L
P
S
Y
L
L
R
N
-
G
K
Y
T
-
R
T
F
F
N
S
----
R
G
--------
L
L
-----------
R
N
--------
I
S
------------
K
----
L
K
F
-
W
-----
P
--
L
-
E
D
--
V
L
T
-----------
E
K
---
Y
K
F
S
K
D
E
A
K
E
I
S
D
F
L
S
P
M
L
Q
L
D
P
R
K
R
A
D
A
G
G
L
V
N
H
--
P
W
L
K
D
T
L
G
M
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
72.18
31%
-34
- C1 -
-
4YLL
10
DYR1A_HUMAN
A:
[18-357]
------------------------------------------------------------------------------------------------------------------------------------------------
D
D
N
Y
D
Y
I
V
K
N
G
E
K
W
-
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
-
V
E
Q
-
E
-
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
-----
T
-----
E
---
K
Y
-
Y
I
V
H
L
K
R
H
F
M
F
----
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
-
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
P
E
-
L
-
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
P
K
-------------------------------------------------------------------------------------------
R
S
A
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
-
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
------
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
P
K
A
--
R
K
F
F
E
K
LPD
G
T
W
--------
N
L
-----------
K
K
-----------------------EYKP
P
G
T
-
R
-----
K
--
L
-
H
N
--
I
L
G
VETGGPGGRRA
G
E
---
S
G
H
T
V
A
D
Y
L
K
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
--
S
F
F
K
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
70.25
31%
-15
* C1 *
-
4YU2
2
DYR1A_HUMAN
A:
[16-358]
----------------------------------------------------------------------------------------------------------------------------------------------
Y
D
D
D
N
Y
D
Y
I
V
K
N
G
E
K
W
-
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
-
V
E
Q
-
E
-
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
-----
T
-----
E
--
M
K
Y
-
Y
I
V
H
L
K
R
H
F
M
F
----
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
-
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
P
E
-
L
-
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
P
K
-------------------------------------------------------------------------------------------
R
S
A
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
-
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
------
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
P
K
-
A
-
R
K
F
F
E
K
LPD
G
T
W
--------
N
L
KKTKDGK----
R
E
--------
Y
K
------------
P
----
P
G
T
-
R
-----
K
--
L
-
H
N
--
I
L
G
VETGGPGGRRA
G
E
---
S
G
H
T
V
A
D
Y
L
K
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
--
S
F
F
K
K
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
70.15
30%
-103
- C1 -
-
5LXC
9
DYRK2_HUMAN
A:
[72-392]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
D
H
V
-
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
H
-
K
V
H
-
Q
-
H
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
-----
K
-----
D
--
N
T
M
-
N
V
I
H
M
L
E
N
F
T
F
----
R
N
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
K
F
-
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
--
H
K
-
N
-
R
I
I
H
C
D
L
K
P
E
N
I
L
L
K
Q
Q
G
R
-------------------------------------------------------------------------------------------
S
G
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
R
-
V
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
------
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
D
A
S
K
R
-
A
-
K
N
F
V
S
S
----
K
G
YPR
Y
C
---
T
V
-----------
T
T
--------
L
S
D
G
S
V
V
L
N
G
G
R
SR
R
----
G
K
L
-
R
-----
G
--
P
-
P
E
--
S
R
E
-----------
W
G
---
N
A
L
K
G
C
D
D
P
L
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
--
P
W
L
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
69.80
30%
-44
- C1 -
-
2EU9
1
CLK3_HUMAN
A:
[5-342]
------------------------------------------------------------------------------------------------------------------------------------------------
K
E
G
H
L
V
-
C
R
I
G
D
W
L
-
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
-
H
-
A
R
G
-
K
S
Q
V
A
L
K
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
-----
K
-----
E
--
N
K
F
-
L
C
V
L
M
S
D
W
F
N
F
----
H
G
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
N
N
F
-
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
--
H
E
-
N
-
Q
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
E
F
E
T
L
Y
-----
N
------------
E
H
-
S
---------------------------------------------------------
C
E
E
K
S
V
K
N
T
S
I
R
V
A
D
F
G
S
A
T
F
D
H
E
H
-
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
------
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
H
R
T
R
K
Q
--
K
Y
F
Y
K
G
----
G
L
--------
V
W
-----------
D
E
--------
N
S
------------
S
----
D
G
R
-
Y
-----
V
--
K
-
E
N
CK
P
L
K
-----------
S
Y
---
M
L
Q
D
S
L
E
H
V
Q
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
--
P
F
F
A
G
L
T
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
HHSearch
64.76
28%
-13
- C1 -
-
4IIR
1
PRP4B_HUMAN
A:
[13-350]
---------------------------------------------------------------------------------------------------------------------------------------------
W
T
D
A
E
G
Y
Y
R
-
V
N
I
G
E
V
L
-
D
K
R
Y
N
V
Y
G
Y
T
G
Q
G
--
S
N
V
V
R
A
R
D
-
N
A
R
A
N
-
Q
-
E
V
A
V
K
I
I
R
N
N
E
L
M
Q
K
T
G
L
K
E
L
E
F
L
K
K
L
N
D
A
D
-----
P
-----
D
--
D
K
F
-
H
C
L
R
L
F
R
H
F
Y
H
----
K
Q
H
L
C
L
V
F
E
P
L
S
M
N
L
R
E
V
L
K
K
Y
G
K
D
V
G
L
H
I
K
A
V
R
S
Y
S
Q
Q
L
F
L
A
L
K
L
L
--
K
R
-
C
-
N
I
L
H
A
D
I
K
P
D
N
I
L
V
N
E
S
K
--------------------------------------------------------------------------------------------
T
I
L
K
L
C
D
F
G
S
A
S
H
V
A
D
N
D
I
T
P
Y
L
V
S
R
F
Y
R
A
P
E
I
I
I
G
K
S
Y
D
Y
G
I
D
M
W
S
V
G
C
T
L
Y
E
L
Y
T
G
K
I
L
F
P
G
K
T
N
------
N
H
M
L
K
L
A
M
D
L
K
G
K
M
P
N
K
M
I
R
K
G
-
V
F
K
-
D
Q
H
F
D
Q
----
N
L
N
F
M
Y
IE----------------
R
--------
E
K
------------
V
----
T
V
M
-
S
TIN--
P
--
T
-
K
D
--
L
L
A
D
LI----------L--
P
E
D
Q
R
K
K
V
H
Q
L
K
D
L
L
D
Q
I
L
M
L
D
P
A
K
R
I
S
I
N
Q
A
L
Q
H
--
A
F
I
Q
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
HHSearch
64.20
30%
-48
- C1 -
-
1Z57
1
CLK1_HUMAN
A:
[9-335]
----------------------------------------------------------------------------------------------------------------------------------------------------------
G
D
V
L
-
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
-
A
G
G
-
R
-
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
-----
P
-----
N
--
S
T
F
-
R
C
V
Q
M
L
E
W
F
E
H
----
H
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
-
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
--
H
S
-
N
-
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
T
E
A
Y
-----
N
-------------------------------------------------------------
R
---
D
-------
E
--
R
T
L
I
N
P
D
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
-
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
------
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
K
-
T
R
K
R
--
K
Y
F
H
H
D---
R
L
--------
D
W
-----------
D
E
--------
H
S
------------
S
----
A
G
R
-
Y
-----
V
S
R
A
-
C
K
--
P
L
K
-----------
E
F
---
M
L
S
Q
D
V
E
H
E
R
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
--
P
F
F
D
L
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
63.99
27%
-95
- C1 -
-
3LLT
1
?
A:
[26-360]
-----------------------------------------------------------------------------------------------------------------------------------------------------
S
-
W
K
K
G
M
L
L
-
N
N
A
F
L
V
I
R
K
M
G
D
G
T
F
G
R
V
L
L
C
Q
H
-
I
-
D
N
K
-
K
-
Y
Y
A
V
K
V
V
R
N
I
K
K
Y
T
R
S
A
K
I
E
A
D
I
L
K
K
I
Q
N
D
------
D
-----
I
--
N
N
N
-
N
I
V
K
Y
H
G
K
F
M
Y
----
Y
D
H
M
C
L
I
F
E
P
L
G
P
S
L
Y
E
I
I
T
R
N
N
Y
-
N
G
F
H
I
E
D
I
K
L
Y
C
I
E
I
L
K
A
L
N
Y
L
--
R
K
-
M
-
S
L
T
H
T
D
L
K
P
E
N
I
L
L
D
D
P
Y
F
E
K
S
L
--
I
T
V
R
R
V
T
-------------------------
D
-------
G
K
---------------------------
K
----
I
Q
---
I
Y
R
T
K
S
T
G
I
K
L
I
D
F
G
C
A
T
F
K
S
D
Y
-
H
G
S
I
I
N
T
R
Q
Y
R
A
P
E
V
I
L
N
L
G
W
D
V
S
S
D
M
W
S
F
G
C
V
L
A
E
L
Y
T
G
S
L
L
F
R
T
H
E
H
------
M
E
H
L
A
M
M
E
S
I
I
Q
P
I
P
K
N
M
L
Y
E
A
T
K
T
N
G
S
K
Y
V
N
K
----
D
E
L-------
K
L
-----------
A
W
--------
P
E
------------
N
----
A
S
S
I
N
-----
S
--
I
-
K
H
--
V
K
K
-----------
C
L
---
P
L
Y
K
I
I
K
H
E
L
F
C
D
F
L
Y
S
I
L
Q
I
D
P
T
L
R
P
S
P
A
E
L
L
K
H
--
K
F
L
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
63.02
30%
-43
- C1 -
-
5J1W
6
CLK1_HUMAN
A:
[10-335]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
L
-
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
-
A
G
G
-
R
-
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
-----
P
-----
N
--
S
T
F
-
R
C
V
Q
M
L
E
W
F
E
H
----
H
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
-
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
--
H
S
-
N
-
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
T
E
A
Y
-----
N
--------------
P
K
-----------------
I
K
--------------------------
R
---
D
-------
E
--
R
T
L
I
N
P
D
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
-
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
------
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
K
-
T
R
K
R
--
K
Y
F
H
H
D---
R
L
--------
D
W
-----------
D
E
--------
H
S
------------
S
----
A
G
R
-
Y
-----
V
S
R
A
-
C
K
--
P
L
K
-----------
E
F
---
M
L
S
Q
D
V
E
H
E
R
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
--
P
F
F
D
L
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
HHSearch
61.61
28%
-13
- C1 -
-
4IJP
1
B:
[13-350]
---------------------------------------------------------------------------------------------------------------------------------------------
W
T
D
A
E
G
Y
Y
R
-
V
N
I
G
E
V
L
-
D
K
R
Y
N
V
Y
G
Y
T
G
Q
G
V
F
S
N
V
V
R
A
R
D
-
N
A
R
A
N
-
Q
-
E
V
A
V
K
I
I
R
N
N
E
L
M
Q
K
T
G
L
K
E
L
E
F
L
K
K
L
N
D
A
D
-----
P
-----
D
--
D
K
F
-
H
C
L
R
L
F
R
H
F
Y
H
----
K
Q
H
L
C
L
V
F
E
P
L
S
M
N
L
R
E
V
L
K
K
Y
G
K
D
V
G
L
H
I
K
A
V
R
S
Y
S
Q
Q
L
F
L
A
L
K
L
L
--
K
R
-
C
-
N
I
L
H
A
D
I
K
P
D
N
I
L
V
N
E
S
K
--------------------------------------------------------------------------------------------
T
I
L
K
L
C
D
F
G
S
A
S
H
V
A
D
N
D
I
T
P
Y
L
V
S
R
F
Y
R
A
P
E
I
I
I
G
K
S
Y
D
Y
G
I
D
M
W
S
V
G
C
T
L
Y
E
L
Y
T
G
K
I
L
F
P
G
K
T
N
N
------
H
M
L
K
L
A
M
D
L
K
G
K
M
P
N
K
M
I
R
K
G
-
V
F
K
-
D
Q
H
F
D
Q
----
N
L
N
F
M
Y
I
E
VD--------------
R
--------
E
K
------------
V
----
T
V
M
-
S
TIN--
P
--
T
-
K
D
--
L
L
A
D
L
I--------
G
C
QRL
P
E
D
Q
R
K
K
V
H
Q
L
K
D
L
L
D
Q
I
L
M
L
D
P
A
K
R
I
S
I
N
Q
A
L
Q
H
--
A
F
I
Q
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
55.07
24%
-31
- C1 -
-
5J1W
6
CLK1_HUMAN
A:
[9-334]
----------------------------------------------------------------------------------------------------------------------------------------------------------
G
D
V
L
-
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
-----
P
-----
N
--
S
T
F
-
R
C
V
Q
M
L
E
W
F
E
H
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
-
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
------
C
--
K
S
-
V
-
N
F
L
H
S
N
-------------------------------
K
L
T
H
T
D
L
K
PEN
I
L
F
V
Q
S
D
Y
T
E
A
Y
N
P
K
I
K
R
D
E
R
T
L
I
N
P
D
-------------------------------------
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
-
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
------
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
-
I
Q
K
T
R
K
R
-
K
Y
F
H
H
D
----
R
L
--------
D
W
DEHS
S
A
G
R
Y
V
S
R
A
--------
C
K
------------
P
----
L
K
E
-
F
-----
M
--
L
S
Q
D
--
V
E
H
-----------
E
R
-------------
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
--
H
P
F
F
D
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
45.60
51%
-140
- C1 -
-
1Q97
1
?
A:
[172-332]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
L
I
Q
I
K
I
A
D
L
G
N
A
C
W
Y
D
E
H
-
Y
T
N
S
I
Q
T
R
E
Y
R
S
P
E
V
L
L
G
A
P
W
G
C
G
A
D
I
W
S
T
A
C
L
I
F
E
L
I
T
G
D
F
L
F
---------
K
D
D
D
H
I
A
Q
I
I
E
L
L
G
E
L
P
-
S
Y
L
L
R
N
G
K
Y
T
-
R
T
F
F
N
S
--------------
L
L
-----------
R
N
--------
I
S
------------
K
----
L
K
F
-
W
-----
P
--
L
-
E
D
--
V
L
T
-----------
E
K
---
Y
K
F
S
K
D
E
A
K
E
I
S
D
F
L
S
P
M
L
Q
L
D
P
R
K
R
A
D
A
G
G
L
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
44.68
51%
-146
- C1 -
-
1Q8Y
1
?
A:
[172-332]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
L
I
Q
I
K
I
A
D
L
G
N
A
C
W
Y
D
E
H
-
Y
T
N
S
I
Q
T
R
E
Y
R
S
P
E
V
L
L
G
A
P
W
G
C
G
A
D
I
W
S
T
A
C
L
I
F
E
L
I
T
G
D
F
L
F
---------
K
D
D
D
H
I
A
Q
I
I
E
L
L
G
E
L
P
-
S
Y
L
L
R
N
G
K
Y
T
-
R
T
F
F
N
S
--------------
L
L
-----------
R
N
--------
I
S
------------
K
----
L
K
F
-
W
-----
P
--
L
-
E
D
--
V
L
T
-----------
E
K
---
Y
K
F
S
K
D
E
A
K
E
I
S
D
F
L
S
P
M
L
Q
L
D
P
R
K
R
A
D
A
G
G
L
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
44.37
51%
-140
- C1 -
-
1Q99
2
SKY1_YEAST
A:
[172-332]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
L
I
Q
I
K
I
A
D
L
G
N
A
C
W
Y
D
E
H
-
Y
T
N
S
I
Q
T
R
E
Y
R
S
P
E
V
L
L
G
A
P
W
G
C
G
A
D
I
W
S
T
A
C
L
I
F
E
L
I
T
G
D
F
L
F
E
-------
T
K
D
D
D
H
I
A
Q
I
I
E
L
L
G
E
L
P
-
S
Y
L
L
R
N
G
K
Y
T
-
R
T
F
F
N
S
--------------
L
L
-----------
R
N
--------
I
S
------------
K
----
L
K
F
-
W
-----
P
--
L
-
E
D
--
V
L
T
-----------
E
K
---
Y
K
F
S
K
D
E
A
K
E
I
S
D
F
L
S
P
M
L
Q
L
D
P
R
K
R
A
D
A
G
G
L
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------