@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
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Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_31_1560: (2018-03-11 )
MLRSGALCKALSSPASLPEASATVSSRGSAADHSIPVSAPVFIDAFEDLTTAKPSLHREPHISSSKSPNELERRRRCYHGTQPCEQVLFTPPVRETVISEEEELSLLHARRMCSSDAQLGTTQAACAWRPASPEFTDLVPFLASQSPLEPLCSSEPAAVAPLSLNATRRASPRDATTDTAAAPTTSGDSSKITMATVSSLTVHTDSNTGRALHSRTSSLLYYSPHIHYDGNSESLETEAALHSSHAAISSSISCFHASSLVTPRALPSYPLSSSSRNSMALTKLQAESSRSEGNRSSSPTGTCGGAACIISDALALTHEKPDHLLLRALASEEGAYVPPLSTFTTTQCTIPPITAPQAEKQNVNTKSGFAPSVPSIRLPVAYSIPVSDSERSLASIPALGYGPRSTPNACSLTSARSGPSARSARHSNRCTSTLRNGVPTLKELFPTLPDELYLTRDRLCISHDSKRRLGSGAYGIVQQAELYPPGVEAPRMFTPTSESAASTSIPSTPCFSPANGRVSIHSFSSIAAAVGNHENVAGASNGGYFGAEQTGRPGAMALAAKTSGNIHFRTVSMFSSDSVTASALPLHQQPYNGQTASFYNGVDDMVRWSSAVESVKDLPWGHALSLNNDATPNMTTAQATVLSPTSGSHETPAFDAVSTASSEGQHSASQSSSVERPLHCKTTAATTMDFNCQTQNDLRLPAVLGLRLGHNPDLRVSPRTSLPVSSGHLSGRVCGAATAVDDAGESTVCTGICEEGRDCLASVIESVRPSRGEGEAVDGETEPWAQHSMTSRTGRGAFALPHSPVGGGRAYRSSSMRVWRRVACGRGNESEGSGLRTYPSFTSPTIHEVSMGTSSAAAVEGKQTPCCEMVVPPATVDAYLHRFLSRTADLVSSKFVDHVDAADHTVREAAVVGADANDKAQAEGYGCLPSALPRALEDREEGGEYEPAEKTSATPERRGPESRRQRMQESLEMSRSSFLVSISYAEHELTCSDAGDETLTLTAQQAIEGAIREAQEEHQHAMDQTPEGTEKTPGAGLRLRLKGHDISCAGSEAQSEMRSDGEAATTTSTDVVLAAAAGEAERMAQRFTHLSTGTSAPASTAMAKSTNAGFFGPRTHVGGGVGGDAILGGHVTPSSTSNSWTPSGTAPIGASAAASAMSATSITRPGNLGGALVSGGTNNTLQSSFDFPRTPAVHHDMKPSMVSDALSSGAVPFRSVATKVIEKVDLTRNAMKLNAFHNELRMASRLRHPCLVNMFGVAEDAKHFYLVMDLAEKGNLAQYQQRFGVRATREMAPQFTADVVLALEYLRDGSQHSYWVTPPPDSTDDSLLQDHRHCTSRTLGMRGSAGEASAAEPRGLPGSTSAHLLRQATESASAATVSKRLSLSAPTTPPLPSQHTGATDATDNVGADACSSVSAVRLVPRESMSESSESPLRTSSTAFGHEPPVPAHTATLPRQQDDNGRSVAQQDSIIVHRDLKPENLLLTWDFHVKLADFGDACFYGDNEANNFGGTPSYISPEVFARCKASPYSDLWALGCVLYELLVGERLFSGSLVEVGTAVQQFKPEALIFPDTLTSTMADSLTAKGRDARERGTGSAAGIAEAAKDLVRQLLQPVPEERLGSAERGGFDALKAHPFFADISWDKVLQTTNMTTTNTNYTAELAEYLEPTEAVVYCSPVKLLPTVEGSSSKEHLSTKSGGTNSRSTQIALVMALTDAPRLLLVNLDLHMVQFEIPWSTELCVSVLRTERFTVTVPFSDVLRSPSIPVPGSTLPPTTTAETSPMHSSSNFSAAAANTITYTFSDCNGRADLWGVKIHHLQSMCSAKLESGSAAGRSLPRLYSTPVVPTAGGAFHLPRSSASSQQLKHQRRRDTPTLSPRAGRRFLQWPRTTPRTMRAGSLGSLTFSSNERSIGAPRDMRSTAATGTCAALSSDACGCTLSARITPATRTRATSSSHRISVSQSSAFTVSSAAAATPCTPSVMLHSSDMLQPPSLTGAALPSFHRGSATVTVTIASSNTSDSPRGSLNTWKANVGDSESVSSPKSPLEFDCTQSTACARPAAPPPLCSTASTSANTPGVSPTNTTAIPIGGEDSPQCGGNVSEARWNGYFLTPATSTCASTGALHPLSASATATYASGSVPESALGCSSSVGNVTPHLAFCSGPRCGGEGLLSNSFEVTHEALSQGEGTPGPWNTPTQADSTTGTPGTPGVLRLPSVCRDKEEGGAVGGGAPIIALAETAPAAAAAAAKLPIKRSQARQQYHGAQKMKSKPCSAAATSSTAEVALEKR
Atome Classification :
(35 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......-----1200......1210......1220.....--.1230......1240....-..1250......1260-.........1270......1280......1290......-1300......1310......1320...---...1330-......1340......1350......1360..---....1370......1380......1390......1400......1410......1420-----........--1430...-----...1440.----.....1450......1460.----------...-..--1470......1480-.-.--.----....1490....-..--1500---.---......1510......1520----..-----.......1530......1540....--..1550-......1560......1570......1580......1590......1600......1610...--...1620......1630......1640----------------------..------------..------..1650......1660......1670......1680......1690......1700......1710......1720......1730......1740......1750......1760......1770......1780......1790......1800......1810......1820......1830......1840......1850......1860......1870......1880......1890......1900......1910......1920......1930......1940......1950......1960......1970......1980......1990......2000......2010......2020......2030......2040......2050......2060......2070......2080......2090......2100......2110......2120......2130......2140......2150......2160......2170......2180......2190......2200......2210......2220......2230......2240......2250......2260......2270......2280
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MLRS
G
A
L
C
K
A
LSSPASLPEASATVSSRGSAADHSIPVSA
P
V
F
I
D
A
F
E
D
LTTAKPSLHREPHISSSK
S
P
N
E
L
E
R
R
R
R
CYHGTQ
P
C
E
Q
VLFTPP
V
R
E
T
VIS
E
E
E
E
L
S
L
L
H
A
R
R
M
CSSDAQLGTTQ
A
A
CAWRPASP
E
F
T
D
L
V
P
F
LASQSPLEPLCSSEPA
A
V
A
P
L
SLNATRRASPRDATTDTAAAPTTSGDSS
K
I
T
M
A
T
V
S
S
L
T
V
H
TDSNTG
R
A
L
H
SRTS
S
L
L
Y
YS
P
H
I
H
YDGNSES
L
E
T
E
A
A
L
H
S
S
H
A
A
I
S
S
S
I
S
C
F
HASSLVTPRALPSYPLSSSSRN
S
M
A
L
T
K
L
QAESSRSEGNRSSSPTGTCG
G
A
A
C
I
I
S
D
A
L
A
LTHEK
P
D
H
L
L
L
R
A
L
ASEEGAYVPPLSTFTTTQCTIPPITAPQAEKQNVNTKSGFAPSVP
S
I
R
L
P
V
A
Y
SIPVSDSERSLASIPALGYGPRSTPNACSLTSARSGPSARSARH
S
N
R
C
T
S
T
L
RNG
V
P
T
L
K
E
L
F
PTL
P
D
E
L
Y
L
TRD
R
L
CISHDSKRRLGSGAY
G
I
V
Q
Q
AELYPPGVEAP
R
M
FTPTSESAASTSIPSTPCFSPAN
G
R
V
S
I
H
S
F
S
S
I
A
A
A
VGNHENVAGASNGGYFGAEQTGRPG
A
M
A
L
A
A
KTSG
N
I
H
F
R
T
V
S
MFSSDSVTASALPLHQQPYNGQT
A
S
F
YN
G
V
D
D
M
V
R
W
S
S
A
V
E
S
V
K
DLPWG
H
A
LSLNNDATPNMT
T
A
Q
A
T
V
LSPTSGSHETPAFDAVSTASSEGQHSASQSSSVERP
L
H
C
KTT
A
A
T
T
M
D
F
NCQTQNDLRL
P
A
V
L
G
LRLGHNPD
L
R
VSPRTSLPVSSGHLSGRVCGAATAVDDAGES
T
V
C
T
G
I
C
EE
G
R
D
C
L
A
S
V
I
E
SVRPSRGEGEAVDGETEPWAQHSMTSRTGRGAFALPHSPVGGG
R
A
YR
S
S
S
M
R
V
W
R
R
V
ACGRGNESEGSGLRTYPSFTSP
T
I
H
E
V
SMGTSSAAAVEGKQTPCCEMVVPP
A
T
V
D
A
Y
L
H
R
F
L
S
R
T
A
D
L
V
S
S
K
F
V
D
H
VDAAD
H
T
V
R
E
A
A
V
VGADANDKAQAEGYGC
L
P
S
A
L
P
R
A
L
E
D
R
EEGGEYEPAEKTSATPERRG
P
E
S
R
R
Q
R
M
Q
E
S
L
E
MSRS
S
F
L
V
S
I
S
YA
E
H
E
L
TCSDAGD
E
T
L
T
L
T
A
Q
Q
A
I
E
G
A
I
R
E
A
Q
E
E
H
Q
H
AMDQTPEGTEKTPGA
G
L
R
L
R
L
KGHDISCAG
S
E
A
Q
S
E
M
RSDGEAATTTST
D
V
V
L
A
AAAG
E
A
E
R
M
A
Q
R
F
T
HLSTGTSAPASTAMAKSTNAGFFGPRTHVGGGVGGD
A
I
LGGHVTPSSTSNSWTPSGTAPI
G
A
S
A
A
A
S
AMS
A
T
SITRPGNLG
G
A
L
VSGGTNNTLQSSFDFPRTPAVHHDM
K
P
-----
S
M
V
S
D
A
L
SSGAV
P
F
R
S
V
A
T
K
V
I
E
K
V
DLTR--N
A
M
K
L
N
A
F
H
N
E
L
R
M
A
S
RLR-H
P
C
L
V
N
M
FGVAED----A
K
H
F
Y
L
V
M
DLAEKG
N
L
A
Q
Y
Q
Q
R
FGV
R
A
T
R
E
MA
P
Q
F
T
A
D
V
-
V
L
A
L
E
Y
L
RDGSQH
S
Y
W
VTPPPDST
D
D
S
---
L
L
Q
D
H
R
H
-
C
T
S
R
TLGMRGSAGEASAAEPRGLPG
S
T
S
A
H
L
L
---
R
Q
A
TESA
S
A
A
T
V
S
K
RLSLSAPTTPPLPSQHTGATDATDNVG
A
D
A
CSSV
S
A
V
R
LV
P
R
-------
E
SMSESSE--SPLRTSS-----TAFGHEPP----VPAHTATLPRQQDDNGRSVA----------QQ
D
-
S
I
--
I
V
HRDLKPE
N
L
L
L
--
T
-
W
--
D
----
F
H
V
K
L
ADFG
D
A
C
-FY--GDN----E---ANNFGGTPSYI
S
P
E
V
F
A
-------
R
C-----KASP
Y
S
D
L
W
A
L
G
C
V
L
Y
E
L
L
V
G
E
RLF--SG
S
L
V
E
-
V
G
T
A
V
Q
QFKPE
A
L
I
FP
D
T
L
T
S
T
M
A
D
S
LTAKGR
D
A
R
ERGTGS
A
A
G
I
A
E
A
A
K
D
L
V
R
Q
L
L
QPV
P
E
E
--RLGSAERGGFDALKAHP
F
F
ADI
S
W
D
K
V
----------------------
L
Q------------TT------NMTTTNTN
Y
T
A
E
L
A
E
YLEPT
E
A
V
V
Y
CSP
V
K
L
L
PTVEGSSSKEHLSTKSGGTNSR
S
T
Q
I
A
L
V
M
ALTDAP
R
L
L
L
V
NL
D
L
H
M
V
Q
F
EIPW
S
T
E
L
C
V
S
V
LRTE
R
F
T
V
T
V
P
F
S
D
V
LRSPSIPVPGSTLPPTTTAETSPMHSSSNFSAAA
A
N
T
I
T
Y
T
FSDCNGRA
D
L
W
G
V
K
I
H
H
L
Q
S
M
C
S
A
K
LESGSAAGRSLPRLYSTPVVPTAGGAFHLPRSSA
S
S
Q
Q
L
K
H
Q
R
RRDTPTLS
P
R
AGRRFLQWPRTTPRTMRAGS
L
G
S
L
T
FSSNERSIGAP
R
D
M
R
STAATG
T
C
A
ALSSDACG
C
T
L
S
A
R
ITPATRTRATSSS
H
R
I
S
VSQS
S
A
F
T
VSSAAAATPCT
P
S
V
M
LHSSDMLQPPSLTGAALPSFHRG
S
A
T
V
T
V
T
I
ASSNTSDSPRGSLN
T
W
KANVGDSESVSSPKS
P
L
E
F
DCTQSTACARPAAPPPLCSTASTSANTPGVSPTN
T
T
A
I
PIGGEDSPQCGGNVSE
A
R
WN
G
Y
F
LTPATSTCASTGALHPLSASA
T
A
TYASGSV
P
E
S
ALGCSSSVGNVTP
H
L
A
FCSGPRCGGEGLLSN
S
F
E
V
T
H
E
A
L
SQGEGTPGPWNTPTQADSTTGTPGTPGVLR
L
P
S
V
CRDKEEGGAVGGGA
P
I
I
A
L
AETAPAA
A
A
A
A
AKLP
I
K
R
S
Q
A
R
Q
Q
YH
G
A
Q
K
MKSKPCSAAATSS
T
A
E
V
A
LEKR
35
HHSearch
77.41
35%
-56
- C1 -
-
5LVO
4
PDPK1_HUMAN
A:
[58-306]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
---
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
S
R
L
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
----
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
-
V
S
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
Y
----------
L
H
G
-
K
G
--
I
I
H
R
D
L
K
P
E
N
I
L
L
--
N
-
E
--
D
----
M
H
I
Q
I
T
D
F
G
T
A
K
-
V
L
--
S
P
E
SKQA
R
---
A
N
S
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
-------
E
K
-----
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
--
R
A
G
N
E
G
L
I
F
A
K
I
I
K
---
L
E
Y
D
F
P
--------------------------
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
E
E
M
E
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
----------------------
H
Q
------------
Q
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
73.18
35%
-46
- C1 -
-
1UVR
6
PDPK1_HUMAN
A:
[36-284]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
---
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
S
R
L
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
----
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
-
V
S
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
Y
----------
L
H
G
-
K
G
--
I
I
H
R
D
L
K
P
E
N
I
L
L
--
N
-
E
--
D
----
M
H
I
Q
I
T
D
F
G
T
A
K
-
V
L
--
S
P
-A---
R
---
A
N
S
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
-------
E
K
-----
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
--
R
A
G
N
E
Y
L
I
F
Q
K
I
I
K
---
L
E
Y
D
F
P
--------------------------
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
E
E
M
E
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
----------------------
H
Q
------------
Q
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
69.82
30%
-40
- C1 -
-
4GV1
4
AKT1_HUMAN
A:
[34-285]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
---
K
D
E
V
A
H
T
L
T
E
N
R
V
L
Q
N
S
R
-
H
P
F
L
T
A
L
K
Y
S
F
Q
T
----
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
V
-
F
S
E
D
R
A
R
F
Y
G
A
E
I
-
V
S
A
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
----------
L
H
S
E
K
N
--
V
V
Y
R
D
L
K
L
E
N
L
M
L
--
D
-
K
--
D
----
G
H
I
K
I
T
D
F
G
L
C
K
-
E
G
--
I
K
D
GA--
T
---
M
K
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
-------
D
N
-----
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
--
Y
N
Q
D
H
E
K
L
F
E
L
I
L
M
---
E
E
I
R
F
P
--------------------------
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
G
S
-
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
----------------------
Y
E
------------
K
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
68.97
29%
-74
- C1 -
-
3WF7
2
KS6B1_HUMAN
A:
[47-294]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
--
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
E
E
V
K
-
H
P
F
I
V
D
L
I
Y
A
F
Q
T
----
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
I
-
F
M
E
D
T
A
C
F
Y
L
A
E
I
-
S
M
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
H
----------
L
H
Q
-
K
G
--
I
I
Y
R
D
L
K
P
E
N
I
M
L
--
N
-
H
--
Q
----
G
H
V
K
L
T
D
F
G
L
C
K
-
E
S
--
I
H
D
--------
T
H
T
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
-------
R
S
-----
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
--
T
G
E
N
R
K
K
T
I
D
K
I
L
K
C
---
K
L
N
L
--------------------------
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
G
A
G
P
-
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
----------------------
L
A
------------
R
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
65.56
30%
-64
- C1 -
-
2VD5
-
DMPK_HUMAN
A:
[87-355]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
V
Y
A
M
K
I
M
N
K
W
D
M
L
K
---
R
G
E
V
S
C
F
R
E
E
R
D
V
L
V
N
G
D
-
R
R
W
I
T
Q
L
H
F
A
F
Q
D
----
E
N
Y
L
Y
L
V
M
E
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F
G
E
R
I
P
A
E
M
A
R
F
Y
L
A
E
I
-
V
M
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
S
----------
V
H
R
-
L
G
--
Y
V
H
R
D
I
K
P
D
N
I
L
L
--
D
-
R
--
C
----
G
H
I
R
L
A
D
F
G
S
C
L
-
K
L
--
R
A
D
----
G
T
V
R
S
L
V
A
V
G
T
P
D
Y
L
S
P
E
I
L
Q
A
V
G
GGPG
T
G
-----
S
Y
G
P
E
C
D
W
W
A
L
G
V
F
A
Y
E
M
F
Y
G
Q
T
P
F
--
Y
A
D
S
T
A
E
T
Y
G
K
I
V
H
Y
K
-
E
H
L
S
L
P
---------------------------
G
V
P
E
E
A
R
D
F
I
Q
R
L
L
C
P
P
E
T
R
LG
R
G
G
A
G
------
D
F
R
T
H
P
F
F
F
G
L
D
W
D
G
L
----------------------
R
D
------------
S
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
Fugue
62.24
25%
8
- C1 -
-
4AW2
5
MRCKA_RAT
A:
[1-416]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
E
V
R
L
R
Q
----
L
E
Q
F
I
L
D
G
P
A
Q
T
N
G
Q
C
F
S
V
E
T
L
L
D
I
L
I
C
L
Y
D
E
C
N
N
S
P
L
R
--------
R
E
K
N
I
L
E
Y
L
E
W
A
K
P
F
T
S
K
V
K
---
Q
M
R
L
H
R
E
D
F
E
I
L
K
V
I
G
R
G
A
F
G
E
V
A
V
V
K
L
K
N
A
D
K
V
F
A
M
K
I
L
N
K
W
E
M
L
K
R
A
E
T
A
C
F
R
E
E
R
D
V
L
V
N
G
D
S
K
W
I
T
T
L
H
Y
A
F
Q
D
D
N
------------
N
L
Y
L
V
M
D
YYVGGD
L
L
T
L
L
S
K
F
E
--
D
R
L
P
E
E
M
-----
A
R
F
Y
L
A
E
M
----
V
I
A
I
D
S
V
H
Q
L
H
---------------------------
Y
V
H
R
D
I
K
P
D
N
I
L
M
--
D
-
M
--
N
----
G
H
I
R
L
A
D
F
G
S
C
L
-
K
L
--
M
E
D
G
T
V
-
Q
---
S
S
V
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
-------
A
M
E
GGKG
R
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
E
T
P
F
Y-
A
E
S
L
V
E
-
T
Y
G
K
I
M
N
-
H
K
E
R
F
Q
F
P
T
Q
V
T
D
-----------------------
V
S
E
N
A
K
D
L
I
R
R
L
I
C
S
-
R
E
H
--
R
L
G
---
Q
N
G
I
E
D
F
K
K
H
P
F
F
S
G
I
D
W
D
N
I
----------------------
R
N
------------
C
E
AP
Y
I
P
E
V
S
S
P
T
D
T
S
N
F
D
V
D
S
G
H
H
L
P
F
V
G
F
T
Y
T
S
S
C
V
L
-------
S
D
R
S
C
L
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
Fugue
60.30
23%
7
- C1 -
-
5KCV
1
AKT1_HUMAN
A:
[20-452]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
K
E
G
W
L
H
K
R
G
E
Y
I
T
W
R
P
R
Y
-
F
L
L
K
N
---
D
G
T
F
I
G
Y
K
E
R
P
A
P
L
N
N
F
S
V
AQ
C
Q
L
M
K
T
E
R
-
P
R
P
N
T
F
I
I
R
C
L
Q
W
-----------
T
T
V
I
E
R
T
F
---
H
V
E
T
P
E
E
R
E
E
W
T
T
A
I
Q
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
T
G
R
Y
Y
A
M
K
I
L
K
K
-------
V
L
Q
N
S
R
H
P
FL
T
A
L
K
Y
S
F
Q
T
HD
R
L
C
F
V
M
E
Y
A
NGGE
L
F
F
H
L
S
R
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
-
K
N
--
V
V
Y
R
D
L
K
L
E
N
L
M
L
--
D
-
K
--
D
----
G
H
I
K
I
T
D
F
G
L
C
------------------------
P
E
Y
L
A
P
E
V
L
E
-------
D
N
-----
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
--
Y
N
Q
--
D
-
H
E
K
L
F
E
L
I
L
M
E
E
I
R
F
P
R
T
L
--------------------------
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
G
S
E
D
A
-
K
E
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
----------------------
Y
E
------------
K
K
------
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
57.27
25%
-70
* C1 *
-
2X4F
4
MYLK4_HUMAN
A:
[115-356]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
L
A
A
K
I
I
K
T
R
G
M
------
K
D
K
E
E
V
K
N
E
I
S
V
M
N
Q
L
D
-
H
A
N
L
I
Q
L
Y
D
A
F
E
S
----
K
N
D
I
V
L
V
M
E
Y
V
D
G
G
E
L
F
D
R
I
I
D
E
S
Y
N
L
T
E
L
D
T
I
L
F
M
K
Q
I
-
C
E
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
H
----------
M
H
Q
-
M
Y
--
I
L
H
L
D
L
K
P
E
N
I
L
C
VN
R
-
D
--
A
----
K
Q
I
K
I
I
D
F
G
L
A
R
-
R
Y
--
K
P
R
E
---
K
---
L
K
V
N
F
G
T
P
E
F
L
A
P
E
V
V
N
-------
Y
D
-----
F
V
S
F
P
T
D
M
W
S
V
G
V
I
A
Y
M
L
L
S
G
L
S
P
F
--
L
G
D
N
D
A
E
T
L
N
N
I
L
A
C
---
R
W
D
L
E
D
----------------------
E
E
F
Q
D
I
S
E
E
A
K
E
F
I
S
K
L
L
I
K
E
K
S
W
--
R
I
S
A
S
------
E
A
L
K
H
P
W
L
S
D
H
K
L
H
S
R
----------------------
L
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
Fugue
56.42
19%
35
- C1 -
-
3C4Z
1
RK_BOVIN
A:
[31-533]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
C
E
A
L
R
E
S
LDLGF
E
G
M
C
L
E
Q
P
I
G
K
R
L
F
Q
Q
F
L
R
T
H
E
Q
H
G
P
A
L
Q
--
L
W
K
D
I
E
D
Y
D
T
A
D
D
A
L
R
P
Q
K
-
A
Q
A
L
R
A
A
Y
L
E
P
Q
A
----
Q
L
F
C
S
F
L
D
A
E
T
V
A
R
A
R
A
G
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
-
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
P
M
G
E
D
W
-------------
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
K
A
T
G
K
L
Y
A
C
K
K
L
N
K
K
R
L
K
K
R
K
G
Y
Q
G
A
M
V
E
K
K
I
L
A
K
V
H
S
R
F
I
V
S
------------
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
-------
I
M
N
G
G
D
I
R
--
Y
H
I
Y
N
V
D
-----
E
---
D
N
P
G
----
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
----------
H
Q
R
-
N
---
I
I
Y
R
D
L
K
P
E
N
V
L
L
--
D
-
D
--
D
----
G
N
V
R
I
S
D
L
G
L
A
V
-
E
L
K
A
G
Q
T
----
K
---
T
K
G
Y
A
G
T
P
G
F
M
A
P
E
L
L
L
-------
G
E
-----
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
--
R
A
R
-----
G
E
K
V
E
N
K
E
L
K
Q
R
V
L
E
Q
A
V
T
--
Y
P
D
K
F
S
------------------
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
--
R
L
G
-
F
R
D
G
S
C
D
G
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
GMLTPP
F
V
P
D
SRTVYAKNGA
F
S
------------
G
V
------
A
F
E
K
A
D
T
E
F
F
Q
E
F
A
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
V
W
R
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
56.11
27%
-37
- C1 -
-
1VZO
1
KS6A5_HUMAN
A:
[82-337]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
L
Y
A
M
K
V
L
K
K
A
T
I
V
Q
--
K
A
K
T
T
E
H
T
R
T
E
R
Q
V
L
E
H
I
R
Q
S
P
F
L
V
T
L
H
Y
A
F
Q
T
----
E
T
K
L
H
L
I
L
D
Y
I
N
G
G
E
L
F
T
H
L
S
Q
R
E
R
-
F
T
E
H
E
V
Q
I
Y
V
G
E
I
-
V
L
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
H
----------
L
H
K
-
L
G
--
I
I
Y
R
D
I
K
L
E
N
I
L
L
--
D
-
S
--
N
----
G
H
V
V
L
T
D
F
G
L
S
K
-
E
F
--
V
A
D
ETE-
R
---
A
Y
D
F
C
G
T
I
E
Y
M
A
P
D
I
V
R
-------
G
G
D------
D
K
A
V
D
W
W
S
L
G
V
L
M
Y
E
L
L
T
G
A
S
P
F
--
T
V
D
G
E
K
N
S
Q
A
E
I
S
R
------
R
I
L
K
S
E
-------------------
P
P
Y
P
Q
E
M
S
A
L
A
K
D
L
I
Q
R
L
L
M
K
D
P
K
K
--
R
L
G
C
G
P
-
R
D
A
D
E
I
K
E
H
L
F
F
Q
K
I
N
W
D
D
L
----------------------
A
A
------------
K
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
HHSearch
53.86
23%
-70
- C1 -
-
5J5T
1
M4K3_HUMAN
A:
[30-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
A
A
I
K
V
I
K
L
E
P
G
------
E
D
F
A
V
V
Q
Q
E
I
I
M
M
K
D
C
K
-
H
P
N
I
V
A
Y
F
G
S
Y
L
R
----
R
D
K
L
W
I
C
M
E
F
C
G
G
G
S
L
Q
D
I
Y
H
V
T
G
P
-
L
S
E
L
Q
I
A
Y
V
S
R
E
T
-
L
Q
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Y
Y
----------
L
H
S
-
K
G
--
K
M
H
R
D
I
K
G
A
N
I
L
L
--
T
-
D
--
N
----
G
H
V
K
L
A
D
F
G
V
S
A
-
Q
I
--
T
A
T
IA--------
A
F
I
G
T
P
Y
W
M
A
P
E
V
A
A
V
ER----
K
G
-----
G
Y
N
Q
L
C
D
L
W
A
V
G
I
T
A
I
E
L
A
E
L
Q
P
P
M
--
F
D
L
H
P
M
R
A
L
F
L
M
T
K
---
S
--
N
F
Q
P
P
K
--------------
L
-----
K
D
K
M
K
W
S
N
S
F
H
H
F
V
K
M
A
L
T
K
N
P
K
K
--
R
P
T
A
E
------
K
L
L
Q
H
P
F
V
T
Q
H
L
T
R
S
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
Fugue
53.03
17%
31
- C1 -
-
2ACX
1
GRK6_HUMAN
A:
[14-532]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
R
K
G
K
S
K
K
W
R
Q
M
L
Q
F
P
H
I
S
Q
C
E
E
L
R
L
S
LERD
Y
H
S
L
C
E
R
N
P
I
G
R
L
L
F
R
E
F
C
A
T
R
P
E
L
S
R
C
V
A
--
F
L
D
G
V
A
E
Y
E
V
T
P
D
D
K
R
K
A
C
-
G
R
N
L
T
Q
N
F
L
S
H
T
G
----
P
D
L
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
E
Q
G
P
C
K
D
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
P
V
---
T
K
N
T
F
R
Q
-
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
R
A
T
G
K
M
Y
A
C
K
K
L
E
K
K
---
R
I
K
K
R
K
G
E
A
M
A
L
N
E
K
Q
I
L
E
K
V
N
S
R
F
V
V
S
------------
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
-------
L
M
N
G
G
D
L
K
--
F
H
I
Y
H
M
G
-----
Q
A
G
F
P
E
A
R
----
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
E
R
-------------------
I
V
Y
R
D
L
K
P
E
N
I
L
L
--
D
-
D
--
H
----
G
H
I
R
I
S
D
L
G
L
A
V
H
V
P
--
E
G
Q
----
T
---
I
K
G
R
V
G
T
V
G
Y
M
A
P
E
V
V
K
-------
N
E
-----
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
F
QQ
R
K
K
K
I
K
-
R
E
E
V
E
R
L
V
K
E
V
P
E
E
Y
S
E
R
F
S
--------------------------
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
--
R
L
G
C
R
G
-
G
S
A
R
E
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
----------------------
G
A
GMLEPPFKPDPQ
A
I
------
Y
C
E
P
T
D
Q
D
F
Y
Q
K
F
A
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
E
C
F
Q
E
L
N
V
F
G
L
D
G
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
52.62
25%
4
- C1 -
-
2X0G
-
DAPK1_HUMAN
A:
[37-284]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
SR
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
----
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
-
L
N
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
Y
----------
L
H
S
-
L
Q
--
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
-
D
--
R
NVP
K
P
R
I
K
I
I
D
F
G
L
A
H
-
K
I
--
D
F
G
N---
E
---
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
-------
Y
E
-----
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
--
L
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
---
N
Y
E
F
E
D
E
----------------------
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
--
R
M
T
I
Q
------
D
S
L
Q
H
P
W
I
K
P
K
D
T
Q
Q
A
----------------------
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
HHSearch
49.20
25%
-9
- C1 -
-
5O2C
4
WNK3_HUMAN
A:
[51-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
V
A
W
C
E
L
Q
D
R
K
L
T
K
--
A
--
E
Q
Q
R
F
K
E
E
A
E
M
L
K
G
L
Q
-
H
P
N
I
V
R
F
Y
D
S
W
E
S
I
L
KG
K
K
C
I
V
L
V
T
E
L
M
T
S
G
T
L
K
T
Y
L
K
R
F
K
-
V
M
K
P
K
V
L
R
S
W
C
R
Q
I
-
L
K
G
L
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
----------
L
H
T
-
R
T
PP
I
I
H
R
D
L
K
C
D
N
I
F
I
--
T
G
P
--
T
----
G
S
V
K
I
G
D
L
G
L
A
T
-
L
M
--
R
T
S
----
F
---
A
K
S
V
I
G
T
P
E
F
M
A
P
E
M
Y
E
--------
E
-----
H
Y
D
E
S
V
D
V
Y
A
F
G
M
C
M
L
E
M
A
T
S
E
Y
P
Y
--
S
E
C
Q
N
A
-
A
-
Q
I
Y
R
K
V
T
S
G
--
I
K
P
A
S
----------------------
F
N
K
V
T
D
P
E
V
K
E
I
I
E
G
C
I
R
Q
N
K
S
E
--
R
L
S
I
R
------
D
L
L
N
H
A
F
F
A
E
D
T
G
L
R
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
48.58
36%
-112
- C1 -
-
3NUU
4
PDPK1_HUMAN
A:
[129-282]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
H
R
D
L
K
P
E
N
I
L
L
--
N
-
E
--
D
----
M
H
I
Q
I
T
D
F
G
T
A
K
-
V
L
--
S
------------
S
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
-------
E
K
-----
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
--
R
A
G
-------------
N
E
Y
L
I
F
Q
K
I
I
K
L
E
Y
---------
D
F
P
E
K
-------
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
E
E
M
E
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
----------------------
H
Q
------------
Q
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
47.71
36%
-111
- C1 -
-
2PE2
3
PDPK1_HUMAN
A:
[128-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
H
R
D
L
K
P
E
N
I
L
L
--
N
-
E
--
D
----
M
H
I
Q
I
T
D
F
G
T
A
K
-
V
L
--
S
-------------
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
-------
E
K
-----
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
--
R
A
G
-------------
N
E
Y
L
I
F
Q
K
I
I
K
L
E
Y
---------
D
F
P
E
K
-------
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
E
E
M
E
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
----------------------
H
Q
------------
Q
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
47.69
36%
-106
- C1 -
-
3NAY
1
PDPK1_HUMAN
A:
[150-303]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
H
R
D
L
K
P
E
N
I
L
L
--
N
-
E
--
D
----
M
H
I
Q
I
T
D
F
G
T
A
K
-
V
L
--
S
-----------
N
S
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
-------
E
K
-----
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
--
R
A
G
-------------
N
E
Y
L
I
F
Q
K
I
I
K
L
E
Y
---------
D
F
P
E
K
-------
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
E
E
M
E
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
----------------------
H
Q
------------
Q
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
Fugue
47.64
17%
3
- C1 -
-
1KOB
1
?
A:
[23-374]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
N
D
Y
D
K
F
Y
E
D
I
W
K
K
Y
V
P
Q
P
V
E
V
K
---
Q
G
S
V
Y
D
Y
-
Y
D
I
L
E
E
L
G
S
G
A
F
G
V
V
H
R
C
V
E
K
A
T
G
R
V
F
V
A
K
F
I
---
N
T
P
Y
P
L
D
K
Y
T
V
K
N
E
I
S
I
M
N
Q
L
H
H
P
K
L
I
N
L
H
D
A
F
E
D
K
Y
--------
E
M
V
L
I
L
E
F
L
S
G
-------
G
E
L
F
D
R
-----------------
I
A
A
E
D
Y
K
----
M
S
E
A
E
V
I
N
Y
M
R
Q
A
C
E
G
L
K
H
M
----------
H
E
H
-
S
---
I
V
H
L
D
I
K
P
E
N
I
M
C
--
E
-
T
KK
A
----
S
S
V
K
I
I
D
F
G
L
A
T
-
K
L
--
N
P
D
----
E
I
--
V
K
V
T
T
A
T
A
E
F
A
A
P
E
I
V
D
-------
R
E
-----
P
V
G
F
Y
T
D
M
W
A
I
G
V
L
G
Y
V
L
L
S
G
L
S
P
F
--
A
G
E
-------------------------
D
D
L
E
T
L
Q
N
V
K
R
C
D
W
E
F
D
E
D
A
F
S
S
V
S
P
E
A
K
D
F
I
K
N
L
L
Q
K
E
P
R
K
--
R
L
T
------
V
H
D
A
L
E
H
P
W
L
K
G
-
D
H
S
N
L
----------------------
T
S
------------
R
I
------
P
S
S
R
Y
N
K
I
R
Q
K
I
K
E
K
Y
A
D
W
P
A
P
Q
P
A
I
G
R
I
A
N
F
S
S
L
R
K
H
R
P
Q
E
Y
Q
I
Y
D
S
Y
F
D
R
K
E
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
47.63
36%
-108
- C1 -
-
2PE0
3
PDPK1_HUMAN
A:
[128-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
H
R
D
L
K
P
E
N
I
L
L
--
N
-
E
--
D
----
M
H
I
Q
I
T
D
F
G
T
A
K
-
V
L
--
S
-------------
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
-------
E
K
-----
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
--
R
A
G
-------------
N
E
Y
L
I
F
Q
K
I
I
K
L
E
Y
---------
D
F
P
E
K
-------
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
E
E
M
E
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
----------------------
H
Q
------------
Q
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
47.12
36%
-108
- C1 -
-
3NUY
4
PDPK1_HUMAN
A:
[129-282]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
H
R
D
L
K
P
E
N
I
L
L
--
N
-
E
--
D
----
M
H
I
Q
I
T
D
F
G
T
A
K
-
V
L
--
S
------------
S
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
-------
E
K
-----
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
--
R
A
G
-------------
N
E
Y
L
I
F
Q
K
I
I
K
L
E
Y
---------
D
F
P
E
K
-------
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
E
E
M
E
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
----------------------
H
Q
------------
Q
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
46.92
36%
-106
- C1 -
-
2PE1
1
PDPK1_HUMAN
A:
[128-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
H
R
D
L
K
P
E
N
I
L
L
--
N
-
E
--
D
----
M
H
I
Q
I
T
D
F
G
T
A
K
-
V
L
--
S
-------------
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
-------
E
K
-----
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
--
R
A
G
-------------
N
E
Y
L
I
F
Q
K
I
I
K
L
E
Y
---------
D
F
P
E
K
-------
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
E
E
M
E
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
----------------------
H
Q
------------
Q
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
45.87
36%
-102
- C1 -
-
3PWY
1
PDPK1_HUMAN
A:
[153-306]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
H
R
D
L
K
P
E
N
I
L
L
--
N
-
E
--
D
----
M
H
I
Q
I
T
D
F
G
T
A
K
-
V
L
--
S
P
-----------
S
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
-------
E
K
-----
S
A
S
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
--
R
A
G
-------------
N
E
Y
L
I
F
Q
K
I
I
K
L
E
Y
---------
D
F
P
E
K
-------
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
E
E
M
E
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
----------------------
H
Q
------------
Q
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
45.59
36%
-105
- C1 -
-
1UU9
4
PDPK1_HUMAN
A:
[130-283]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
H
R
D
L
K
P
E
N
I
L
L
--
N
-
E
--
D
----
M
H
I
Q
I
T
D
F
G
T
A
K
-
V
L
--------------
N
S
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
-------
E
K
-----
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
--
R
A
G
-------------
N
E
Y
L
I
F
Q
K
I
I
K
L
E
Y
---------
D
F
P
E
K
-------
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
E
E
M
E
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
----------------------
H
Q
------------
Q
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
45.42
36%
-103
- C1 -
-
1Z5M
2
PDPK1_HUMAN
A:
[128-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
H
R
D
L
K
P
E
N
I
L
L
--
N
-
E
--
D
----
M
H
I
Q
I
T
D
F
G
T
A
K
-
V
L
--
S
-------------
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
-------
E
K
-----
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
--
R
A
G
-------------
N
E
Y
L
I
F
Q
K
I
I
K
L
E
Y
---------
D
F
P
E
K
-------
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
E
E
M
E
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
----------------------
H
Q
------------
Q
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
44.86
36%
-107
- C1 -
-
3NUN
4
PDPK1_HUMAN
A:
[135-288]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
H
R
D
L
K
P
E
N
I
L
L
--
N
-
E
--
D
----
M
H
I
Q
I
T
D
F
G
T
A
K
-
V
L
--
S
------------
S
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
-------
E
K
-----
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
--
R
A
G
-------------
N
E
Y
L
I
F
Q
K
I
I
K
L
E
Y
---------
D
F
P
E
K
-------
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
E
E
M
E
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
----------------------
H
Q
------------
Q
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
44.55
35%
-77
- C1 -
-
3TXO
1
A:
[138-295]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
F
----------
L
H
D
-
K
G
--
I
I
Y
R
D
L
K
L
D
N
V
L
L
--
D
-
H
--
E
----
G
H
C
K
L
A
D
F
G
M
C
K
-
E
G
--
I
C
--------------
G
T
P
D
Y
I
A
P
E
I
L
Q
-------
E
M
-----
L
Y
G
P
A
V
D
W
W
A
M
G
V
L
L
Y
E
M
L
C
G
H
A
P
F
--
E
A
E
N
E
D
D
L
F
E
A
I
L
N
---
D
E
V
V
Y
P
--------------------------
T
W
L
H
E
D
A
T
G
I
L
K
S
F
M
T
K
N
P
T
M
--
R
L
G
S
L
T
Q
G
G
E
H
A
I
L
R
H
P
F
F
K
E
I
D
W
A
Q
L
----------------------
N
H
------------
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
37.63
36%
-18
- C1 -
-
4CT2
2
PDPK1_HUMAN
A:
[153-306]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
H
R
D
L
K
P
E
N
I
L
L
--
N
-
E
--
D
----
M
H
I
Q
I
T
D
F
G
T
A
K
-
V
L
--
S
P
E
SKQA
R
---
A
N
S
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
-------
E
K
-----
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
--
R
A
G
-------------
N
E
G
L
I
F
A
K
I
I
K
L
E
Y
---------
D
F
P
E
K
-------
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
E
E
M
E
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
----------------------
H
Q
------------
Q
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
37.59
36%
-19
- C1 -
-
4AW0
3
PDPK1_HUMAN
A:
[153-306]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
H
R
D
L
K
P
E
N
I
L
L
--
N
-
E
--
D
----
M
H
I
Q
I
T
D
F
G
T
A
K
-
V
L
--
S
P
E
SKQA
R
---
A
N
S
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
-------
E
K
-----
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
--
R
A
G
-------------
N
E
G
L
I
F
A
K
I
I
K
L
E
Y
---------
D
F
P
E
K
-------
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
E
E
M
E
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
----------------------
H
Q
------------
Q
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
36.76
36%
-13
- C1 -
-
1H1W
5
PDPK1_HUMAN
A:
[131-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
H
R
D
L
K
P
E
N
I
L
L
--
N
-
E
--
D
----
M
H
I
Q
I
T
D
F
G
T
A
K
-
V
L
--
S
P
-A---
R
---
A
N
S
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
-------
E
K
-----
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
--
R
A
G
-------------
N
E
Y
L
I
F
Q
K
I
I
K
L
E
Y
---------
D
F
P
E
K
-------
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
E
E
M
E
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
----------------------
H
Q
------------
Q
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
36.72
36%
-24
- C1 -
-
1UVR
4
PDPK1_HUMAN
A:
[131-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
H
R
D
L
K
P
E
N
I
L
L
--
N
-
E
--
D
----
M
H
I
Q
I
T
D
F
G
T
A
K
-
V
L
--
S
P
-A---
R
---
A
N
S
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
-------
E
K
-----
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
--
R
A
G
-------------
N
E
Y
L
I
F
Q
K
I
I
K
L
E
Y
---------
D
F
P
E
K
-------
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
E
E
M
E
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
----------------------
H
Q
------------
Q
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
36.64
36%
-26
- C1 -
-
3HRC
1
PDPK1_HUMAN
A:
[153-306]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
H
R
D
L
K
P
E
N
I
L
L
--
N
-
E
--
D
----
M
H
I
Q
I
T
D
F
G
T
A
K
-
V
L
--
S
P
-A---
R
---
A
N
S
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
-------
E
K
-----
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
--
R
A
G
-------------
N
E
G
L
I
F
A
K
I
I
K
L
E
Y
---------
D
F
P
E
K
-------
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
E
E
M
E
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
----------------------
H
Q
------------
Q
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
36.45
36%
-17
- C1 -
-
3HRF
3
PDPK1_HUMAN
A:
[153-306]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
H
R
D
L
K
P
E
N
I
L
L
--
N
-
E
--
D
----
M
H
I
Q
I
T
D
F
G
T
A
K
-
V
L
--
S
P
E
SKQA
R
---
A
N
S
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
-------
E
K
-----
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
--
R
A
G
-------------
N
E
G
L
I
F
A
K
I
I
K
L
E
Y
---------
D
F
P
E
K
-------
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
E
E
M
E
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
----------------------
H
Q
------------
Q
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
36.29
36%
-15
- C1 -
-
4CT1
3
PDPK1_HUMAN
A:
[153-306]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
H
R
D
L
K
P
E
N
I
L
L
--
N
-
E
--
D
----
M
H
I
Q
I
T
D
F
G
T
A
K
-
V
L
--
S
P
E
SKQA
R
---
A
N
S
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
-------
E
K
-----
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
--
R
A
G
-------------
N
E
G
L
I
F
A
K
I
I
K
L
E
Y
---------
D
F
P
E
K
-------
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
E
E
M
E
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
----------------------
H
Q
------------
Q
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
36.00
36%
-20
- C1 -
-
4XX9
5
PDPK1_HUMAN
A:
[152-305]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
H
R
D
L
K
P
E
N
I
L
L
--
N
-
E
--
D
----
M
H
I
Q
I
T
D
F
G
T
A
K
-
V
L
--
S
P
E
SKQA
R
---
A
N
S
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
-------
E
K
-----
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
--
R
A
G
-------------
N
E
G
L
I
F
A
K
I
I
K
L
E
Y
---------
D
F
P
E
K
-------
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
E
E
M
E
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
----------------------
H
Q
------------
Q
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
32.05
36%
-20
- C1 -
-
3NAX
1
PDPK1_HUMAN
A:
[150-303]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
H
R
D
L
K
P
E
N
I
L
L
--
N
-
E
--
D
----
M
H
I
Q
I
T
D
F
G
T
A
K
-
V
L
--
S
P
E
SKQA
R
---
A
-------
Q
Y
V
S
P
E
L
L
T
-------
E
K
-----
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
--
R
A
G
-------------
N
E
Y
L
I
F
Q
K
I
I
K
L
E
Y
---------
D
F
P
E
K
-------
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
E
E
M
E
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
----------------------
H
Q
------------
Q
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------