@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_31_3070: (2018-03-12 )
MEEQDQRKPNGGNNGLPVPPSTTETGQGPLQDILGRTPNCQYVKKRLLGQGSFGSAWRVEESATGNVFAAKVMDLNSMSEKDRGFVTNEVKCLSRCCNPHVVRCENAIEREGQLLIVMEYADGGDLYKQIKARVREMKFFREHEVVFIFLQLCLALDHIHSNKMMHRDLKTANILLTTTGLVKLGDFGFSRQYEDSLSNAVGSTFCGTPYYLSPELWHRQPYSKKSEMWALGVVLYEVMALRRPFTGKNMDELITNICHGRRSDLPSSYSASLRDVCNRLLSVDSNTRPTIHELFHEPFIRSNLETLKRSVEKHNRIPADVREAIARCITQSLNTEEPPAHLEEPEPLIGTVKRHTALRGWQKCLLSFDKKQISIRDPSGVDPEEVVPVATLTSVCPIDVMMAGEEFVFAMKNQAGKAFWFMAPTQRAYEQWLTTLQEAAP
Atome Classification :
(22 SA)
.........10........20........30........40........50........60....-....70.......-.------80........90.....-...100..-.....110.-......120.......130.......140.......150.......160---.-........170.....--.--.---180-.........190.......200.......210......------.220........230.......240.......250-........260---.---.---.---....-.---270.......280.......-----290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MEEQDQRKPNGGNNGLPVPPSTTETGQG
P
L
Q
D
I
LGRTP
N
C
Q
Y
V
K
K
R
LLGQGSFG
S
A
W
R
V
EESATG-
N
V
F
A
A
K
V
MDLNSM-S------EKDRGFV
T
N
E
V
K
C
L
S
RC-CNP
H
V
V
R
C
-
E
N
A
IEREG
Q
-
L
L
I
V
M
E
YADG
G
D
L
Y
K
Q
I
K
A
R
V
R
E
M
K
F
F
R
EH
E
V
V
F
I
F
L
Q
L
C
L
A
L
D
H
IH-----S-
N
K
M
M
H
RDLKT
A
N
I
L
L
T--T--T---G---
L
V
K
LGDFGF
S
R
Q
Y
E
D
S
L
S
N
AVGSTFCGTPYYL
S
P
E
L
WH------RQP-YS
K
K
S
E
M
W
A
L
G
V
V
L
Y
E
V
M
A
L
RRPFTGK
N
M
D
--
E
L
I
T
N
I
CHGR----R---S---D---LP
S
S
-
Y
---
S
A
S
L
R
D
V
C
N
R
L
L
SVDSNTR
P
-----
T
I
H
E
L
F
H
E
P
F
I
R
S
N
L
E
T
L
K
R
S
V
E
K
HNRI
P
A
D
V
R
E
A
I
A
R
C
I
T
Q
SLNTEEPPAHLEEPE
P
L
I
G
T
V
K
R
H
T
A
L
R
G
W
Q
K
C
L
L
S
FDK
K
Q
I
S
IRDPSGV
D
P
E
EVV
P
V
A
T
L
TSVCP
I
D
V
M
MAGEE
F
V
F
A
M
KNQAG
K
A
F
W
F
MA
P
T
Q
R
A
Y
E
Q
W
L
T
T
L
Q
EAAP
2
PsiBlast_PDB
86.54
36%
-140
- C1 -
-
4B9D
1
NEK1_HUMAN
A:
[25-287]
----------------------------------------
K
Y
V
R
L
Q
K
I
------
K
A
I
L
V
K
S
T
E
D
G
-
R
Q
Y
V
I
K
E
I
N
I
S
R
M
-
S
------
S
K
E
R
E
E
S
R
R
E
V
A
V
L
A
N
M
-
K
H
P
N
I
V
Q
Y
-
R
E
S
F
E
E
N
G
S
-
L
Y
I
V
M
D
Y
C
E
G
G
D
L
F
K
R
I
N
A
Q
--
K
G
V
L
F
Q
E
D
Q
I
L
D
W
F
V
Q
I
C
L
A
L
K
H
V
H
-----
D
-
R
K
I
L
H
R
D
I
K
S
Q
N
I
F
L
T
--
K
--
D
---
G
---
T
V
Q
L
G
D
F
G
I
A
R
V
L
N
S
T
V
E
--
L
A
R
A
C
I
G
T
P
Y
Y
L
S
P
E
I
C
E
------
N
K
P
-
Y
N
N
K
S
D
I
W
A
L
G
C
V
L
Y
E
L
C
T
L
K
H
A
F
E
A
G
S
M
K
--
N
L
V
L
K
I
I
S
G
S
----
F
---
P
---
P
---
V
S
L
H
-
Y
---
S
Y
D
L
R
S
L
V
S
Q
L
F
K
R
N
P
R
D
R
P
-----
S
V
N
S
I
L
E
K
G
F
I
A
K
R
I
E
K
F
--------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
86.28
36%
-140
- C1 -
-
4APC
-
NEK1_HUMAN
A:
[25-287]
----------------------------------------
K
Y
V
R
L
Q
K
I
------
K
A
I
L
V
K
S
T
E
D
G
-
R
Q
Y
V
I
K
E
I
N
I
S
R
M
-
S
------
S
K
E
R
E
E
S
R
R
E
V
A
V
L
A
N
M
-
K
H
P
N
I
V
Q
Y
-
R
E
S
F
E
E
N
G
S
-
L
Y
I
V
M
D
Y
C
E
G
G
D
L
F
K
R
I
N
A
Q
--
K
G
V
L
F
Q
E
D
Q
I
L
D
W
F
V
Q
I
C
L
A
L
K
H
V
H
-----
D
-
R
K
I
L
H
R
D
I
K
S
Q
N
I
F
L
T
--
K
--
D
---
G
---
T
V
Q
L
G
D
F
G
I
A
R
V
L
N
S
T
V
E
--
L
A
R
A
C
I
G
T
P
Y
Y
L
S
P
E
I
C
E
------
N
K
P
-
Y
N
N
K
S
D
I
W
A
L
G
C
V
L
Y
E
L
C
T
L
K
H
A
F
E
A
G
S
M
K
--
N
L
V
L
K
I
I
S
G
S
----
F
---
P
---
P
---
V
S
L
H
-
Y
---
S
Y
D
L
R
S
L
V
S
Q
L
F
K
R
N
P
R
D
R
P
-----
S
V
N
S
I
L
E
K
G
F
I
A
K
R
I
E
K
F
--------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
73.88
31%
-61
- C1 -
-
2BDW
-
KCC2D_CAEEL
A:
[9-274]
-------------------------------------
F
S
D
N
Y
D
V
K
E
E
L
G
K
G
A
F
S
V
V
R
R
C
V
H
K
T
T
G
-
L
E
F
A
A
K
I
I
N
T
K
K
L
-
S
------
A
R
D
F
Q
K
L
E
R
E
A
R
I
C
R
K
L
-
Q
H
P
N
I
V
R
L
-
H
D
S
I
Q
E
E
S
F
-
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
----
F
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
I
A
Y
C
H
-----
S
-
N
G
I
V
H
R
N
L
K
P
E
N
L
L
L
A
--
S
--
K
---
A
KG
A
A
V
K
L
A
D
F
G
L
A
I
E
V
N
D
S
E
---
A
W
H
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
K
------
K
D
P
-
Y
S
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
H
--
R
L
Y
A
Q
I
K
A
G
A
----
Y
---
D
Y
P
S
P
---
E
W
D
T
-
V
---
T
P
E
A
K
S
L
I
D
S
M
L
T
V
N
P
K
K
R
I
-----
T
A
D
Q
A
L
K
V
P
W
I
C
N
R
------------------------------------------------------------------------------------------------------------------------------------------
46
Fugue
71.34
24%
-16
- C1 -
-
1KOB
1
?
A:
[23-374]
I
N
D
Y
D
K
F
Y
E
D
I
W
K
K
Y
V
P
Q
P
V
E
V
K
Q
G
S
V
Y
D
-----------
Y
Y
D
I
L
E
E
L
G
S
G
A
F
G
V
V
H
R
C
V
E
K
A
T
G
-
R
V
F
V
A
K
F
I
N
T
P
Y
---------
P
L
D
K
Y
T
V
K
N
E
I
S
I
M
N
Q
L
-
H
H
P
K
L
I
N
L
-
H
D
A
F
E
D
K
Y
E
-
M
V
L
I
L
E
F
L
S
G
G
E
L
F
D
R
I
---
A
A
E
D
Y
K
M
S
E
A
E
V
I
N
Y
M
R
Q
A
C
E
G
L
K
H
M
H
-----
E
-
H
S
I
V
H
L
D
I
K
P
E
N
I
M
C
E
TK
K
--
A
---
S
---
S
V
K
I
I
D
F
G
L
A
T
K
L
N
---
P
D
E
I
V
K
V
T
T
A
T
A
E
F
A
A
P
E
I
V
D
------
R
E
P
-
V
G
F
Y
T
D
M
W
A
I
G
V
L
G
Y
V
L
L
S
G
L
S
P
F
A
G
E
D
D
L
--
E
T
L
Q
N
V
K
R
C
D
W
E
F
-
D
---
E
---
D
---
A
F
S
S
-
V
---
S
P
E
A
K
D
F
I
K
N
L
L
Q
K
E
P
R
K
R
L
-----
T
V
H
D
A
L
E
H
P
W
L
K
G
D
H
S
N
L
T
S
R
I
P
S
S
R
Y
N
K
I
R
Q
K
I
K
E
K
Y
------------
A
D
W
P
A
P
Q
P
A
I
G
R
I
A
N
F
S
S
L
R
K
H
R
P
Q
E
Y
Q
I
Y
D
S
Y
F
D
R
K
E
A
---------------------------------------------------------------
47
Fugue
68.59
22%
-38
- C1 -
-
1TKI
-
TITIN_HUMAN
A:
[18-338]
-----------------------------------
K
E
L
Y
E
K
Y
M
I
A
E
D
L
G
R
G
E
F
G
I
V
H
R
C
V
E
T
S
S
K
-
K
T
Y
M
A
K
F
V
---
K
V
-
K
------
G
T
D
Q
V
L
V
K
K
E
I
S
I
L
N
I
A
-
R
H
R
N
I
L
H
L
-
H
E
S
F
E
S
M
E
E
-
L
V
M
I
F
E
F
I
S
G
L
D
I
F
E
R
I
N
T
S
A
F
E
---
L
N
E
R
E
I
V
S
Y
V
H
Q
V
C
E
A
L
Q
F
L
H
-----
S
-
H
N
I
G
H
F
D
I
R
P
E
N
I
I
Y
Q
--
T
RR
S
---
S
---
T
I
K
I
I
E
F
G
Q
A
R
Q
L
K
P
---
G
D
N
F
R
L
L
F
T
A
P
E
Y
Y
A
P
E
V
H
Q
------
H
D
V
-
V
S
T
A
T
D
M
W
S
L
G
T
L
V
Y
V
L
L
S
G
I
N
P
F
L
A
E
T
N
Q
--
Q
I
I
E
N
I
M
N
A
E
----
Y
---
T
---
F
---
D
E
E
A
-
F
KEI
S
I
E
A
M
D
F
V
D
R
L
L
V
K
E
R
K
S
R
M
-----
T
A
S
E
A
L
Q
H
P
W
L
K
Q
K
I
E
R
V
S
T
K
V
I
R
----
T
L
K
H
R
R
Y
Y
H
T
L
I
K
K
D
L
N
M
V
V
S
A
A
R
I
S
C
G
G
A
I
R
S
Q
-----------------------------------------------------------------------------
K
G
V
S
V
A
K
V
K
V
A
S
I
21
HHSearch
67.60
25%
-61
- C1 -
-
1TKI
-
TITIN_HUMAN
A:
[21-284]
--------------------------------------
Y
E
K
Y
M
I
A
E
D
L
G
R
G
E
F
G
I
V
H
R
C
V
E
T
S
S
K
-
K
T
Y
M
A
K
F
V
K
V
K
G
----------
T
D
Q
V
L
V
K
K
E
I
S
I
L
N
I
A
-
R
H
R
N
I
L
H
L
-
H
E
S
F
E
S
M
E
E
-
L
V
M
I
F
E
F
I
S
G
L
D
I
F
E
R
I
N
T
S
A
---
F
E
L
N
E
R
E
I
V
S
Y
V
H
Q
V
C
E
A
L
Q
F
L
H
-----
S
-
H
N
I
G
H
F
D
I
R
P
E
N
I
I
Y
Q
--
T
RR
S
---
S
---
T
I
K
I
I
E
F
G
Q
A
R
Q
L
K
P
G
---
D
N
F
R
L
L
F
T
A
P
E
Y
Y
A
P
E
V
H
Q
------
H
D
V
-
V
S
T
A
T
D
M
W
S
L
G
T
L
V
Y
V
L
L
S
G
I
N
P
F
L
A
E
T
N
Q
--
Q
I
I
E
N
I
M
N
A
E
----
Y
TFD
E
---
E
---
A
F
K
E
-
I
---
S
I
E
A
M
D
F
V
D
R
L
L
V
K
E
R
K
S
R
M
-----
T
A
S
E
A
L
Q
H
P
W
L
K
Q
K
I
E
R
---------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
67.02
30%
0
- C1 -
-
2Y7J
1
PHKG2_HUMAN
D:
[93-364]
--------------------------------------
Y
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
-
H
E
F
A
V
K
I
M
E
V
----
R
LSPEQL
E
E
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
-
I
D
S
Y
E
S
S
S
F
-
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
V
----
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
-----
A
-
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
D
--
D
--
N
---
M
---
Q
I
R
L
S
D
F
G
F
S
C
H
L
E
P
G
---
E
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
CSMDET
H
P
G
-
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
R
R
Q
I
--
L
M
L
R
M
I
M
E
G
Q
----
Y
---
Q
---
F
SSP
E
W
D
D
-
R
---
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
-----
T
A
E
Q
A
L
Q
H
P
F
F
E
--------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
66.94
30%
-2
- C1 -
-
2Y7J
1
PHKG2_HUMAN
C:
[93-364]
--------------------------------------
Y
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
-
H
E
F
A
V
K
I
M
E
V
T
A
E
-
R
LSPEQL
E
E
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
-
I
D
S
Y
E
S
S
S
F
-
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
V
----
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
-----
A
-
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
D
--
D
--
N
---
M
---
Q
I
R
L
S
D
F
G
F
S
C
H
L
E
P
G
---
E
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
CSMDET
H
P
G
-
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
R
R
Q
I
--
L
M
L
R
M
I
M
E
G
Q
----
Y
---
Q
---
F
SSP
E
W
D
D
-
R
---
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
-----
T
A
E
Q
A
L
Q
H
P
F
F
E
--------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
66.35
31%
0
- C- -
-
2WEL
7
KCC2D_HUMAN
A:
[3-271]
--------------------------------------
T
D
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
-
Q
E
Y
A
A
K
I
I
N
T
K
K
L
-
S
------
A
R
D
H
Q
K
L
E
R
E
A
R
I
C
R
L
L
-
K
H
P
N
I
V
R
L
-
H
D
S
I
S
E
E
G
F
-
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
----
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
-----
L
-
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
--
S
--
K
SKG
A
---
A
V
K
L
A
D
F
G
L
A
I
E
V
Q
G
D
Q
--
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
------
K
D
P
-
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
H
--
R
L
Y
Q
Q
I
K
A
G
A
----
Y
DFP
S
---
P
---
E
W
D
T
-
V
---
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
-----
T
A
S
E
A
L
K
H
P
W
I
C
Q
R
------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
66.32
34%
-47
- C1 -
-
2WQN
1
NEK7_HUMAN
A:
[21-289]
----------------------------
A
L
R
P
D
M
G
Y
N
T
L
A
N
F
R
I
E
K
K
I
G
R
G
Q
F
S
E
V
Y
R
A
A
C
L
L
D
G
V
P
V
A
L
K
K
V
Q
I
F
D
L
M
-
D
------
A
K
A
R
A
D
C
I
K
E
I
D
L
L
K
Q
L
-
N
H
P
N
V
I
K
Y
-
Y
A
S
F
I
E
D
N
E
-
L
N
I
V
L
E
L
A
D
A
G
D
L
S
R
M
I
K
H
F
K
K
Q
K
R
L
I
P
E
R
T
V
W
K
Y
F
V
Q
L
C
S
A
L
E
H
M
H
-----
S
-
R
R
V
M
H
R
D
I
K
P
A
N
V
F
I
T
--
A
--
T
---
G
---
V
V
K
L
G
D
L
--------------------
T
P
Y
Y
M
S
P
E
R
I
H
------
E
N
G
-
Y
N
F
K
S
D
I
W
S
L
G
C
L
L
Y
E
M
A
A
L
Q
S
P
F
Y
---
M
N
L
Y
S
L
C
K
K
I
E
Q
C
D
----
Y
---
P
---
P
---
L
P
S
D
H
Y
---
S
E
E
L
R
Q
L
V
N
M
C
I
N
P
D
P
E
K
R
P
-----
D
V
T
Y
V
Y
--------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
65.90
36%
-21
- C1 -
-
2W5B
1
NEK2_HUMAN
A:
[14-271]
-----------------------------------------------
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
S
D
G
-
K
I
L
V
W
K
E
L
D
Y
G
S
M
-
T
------
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
-
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S-------
L
H
R
D
L
K
P
A
N
V
F
L
D
--
G
--
K
---
Q
---
N
V
K
L
G
D
F
G
L
A
R
I
L
N
H
D
T
S
F
A
--
K
A
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
------
R
M
S
-
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
--
E
L
A
G
K
I
R
E
G
K
----
F
---
R
---
R
---
I
P
Y
R
-
Y
---
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
-----
S
V
E
E
I
L
E
N
P
L
I
---------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
65.75
36%
-36
- C1 -
-
2W5A
5
NEK2_HUMAN
A:
[14-271]
-----------------------------------------------
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
S
D
G
-
K
I
L
V
W
K
E
L
D
Y
G
S
M
-
T
------
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
-
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S-------
L
H
R
D
L
K
P
A
N
V
F
L
D
--
G
--
K
---
Q
---
N
V
K
L
G
D
F
G
L
A
R
I
L
---
T
S
F
A
--
K
T
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
------
R
M
--
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
--
E
L
A
G
K
I
R
E
G
K
----
F
---
R
---
R
---
I
P
Y
R
-
Y
---
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
-----
S
V
E
E
I
L
E
N
P
L
I
---------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
65.72
28%
-72
- C1 -
-
5J5T
1
M4K3_HUMAN
A:
[4-269]
---------------------------------------
E
D
F
E
L
I
Q
R
I
G
S
G
T
Y
G
D
V
Y
K
A
R
N
V
N
T
G
-
E
L
A
A
I
K
V
I
K
L
E
P
---------
G
E
D
F
A
V
V
Q
Q
E
I
I
M
M
K
D
C
-
K
H
P
N
I
V
A
Y
-
F
G
S
Y
L
R
R
D
K
-
L
W
I
C
M
E
F
C
G
G
G
S
L
Q
D
I
Y
H
V
T
G
----
P
L
S
E
L
Q
I
A
Y
V
S
R
E
T
L
Q
G
L
Y
Y
L
H
-----
S
-
K
G
K
M
H
R
D
I
K
G
A
N
I
L
L
T
--
D
--
N
---
G
---
H
V
K
L
A
D
F
G
V
S
A
Q
I
T
A
T
I
--
A
---
A
F
I
G
T
P
Y
W
M
A
P
E
V
A
A
V
ER---
K
G
G
-
Y
N
Q
L
C
D
L
W
A
V
G
I
T
A
I
E
L
A
E
L
Q
P
P
M
F
D
L
H
P
M
--
R
A
L
F
L
M
T
K
S
N
F
Q
P
P
K
---
L
---
K
---
D
K
M
K
-
W
---
S
N
S
F
H
H
F
V
K
M
A
L
T
K
N
P
K
K
R
P
-----
T
A
E
K
L
L
Q
H
P
F
V
T
Q
H
L
-----------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
65.68
29%
-76
- C1 -
-
4XBR
1
INKA1_HUMAN (first)
A:
[93-350]
--------------------------------------
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
-
K
L
V
A
V
K
K
M
D
L
R
K
---------
Q
Q
R
R
E
L
L
F
N
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
-
Y
N
S
Y
L
V
G
D
E
-
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
T
-----
R
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
-----
A
-
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
--
H
--
D
---
G
---
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
--
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
------
R
L
P
-
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
--
K
A
M
K
M
I
R
D
N
L
----
P
---
P
RL-
K
---
N
L
H
K
-
V
---
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
-----
T
A
A
E
L
L
K
H
P
F
L
A
K
A
------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
65.40
28%
-111
* C1 *
-
5K00
1
MELK_HUMAN
A:
[8-266]
---------------------------------------
K
Y
Y
E
L
H
E
T
I
G
T
G
--
A
K
V
K
L
A
C
H
I
L
T
G
-
E
M
V
A
I
K
I
M
D
K
N
T
L
--------
G
S
D
L
P
R
I
K
T
E
I
E
A
L
K
N
L
-
R
H
Q
H
I
C
Q
L
-
Y
H
V
L
E
T
A
N
K
-
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
----
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
-----
S
-
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
--
E
--
Y
---
H
---
K
L
K
L
I
D
F
G
L
C
A
K
P
--------------
S
L
A
Y
A
A
P
E
L
I
Q
------
G
K
S
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
M
--
A
L
Y
K
K
I
M
R
G
K
----
Y
-------
D
---
V
P
K
W
-
L
---
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
W
I
M
Q
D
Y
-----------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
64.34
34%
-43
- C1 -
-
5DE2
-
NEK7_HUMAN
A:
[20-289]
---------------------------
K
A
L
R
P
D
M
G
Y
N
T
L
A
N
F
R
I
E
K
K
I
G
R
G
Q
F
S
E
V
Y
R
A
A
C
L
L
D
G
V
P
V
A
L
K
K
V
Q
I
F
D
L
M
-
D
------
A
K
A
R
A
D
C
I
K
E
I
D
L
L
K
Q
L
-
N
H
P
N
V
I
K
F
-
Y
A
S
F
I
E
D
N
E
-
L
N
I
V
L
E
L
A
D
A
G
D
L
S
R
M
I
K
H
F
K
K
Q
K
R
L
I
P
E
R
T
V
W
K
Y
F
V
Q
L
C
S
A
L
E
H
M
H
-----
S
-
R
R
V
M
H
R
D
I
K
P
A
N
V
F
I
T
--
A
--
T
---
G
---
V
V
K
L
G
D
L
G
L
----------------
V
G
T
P
Y
Y
M
S
P
E
R
I
H
------
E
N
G
-
Y
N
F
K
S
D
I
W
S
L
G
C
L
L
Y
E
M
A
A
L
Q
S
P
F
Y
G
D
K
M
N
L
Y
S
L
C
K
K
I
E
Q
C
D
----
Y
---
P
---
P
---
L
P
S
D
H
Y
---
S
E
E
L
R
Q
L
V
N
M
C
I
N
P
D
P
E
K
R
P
-----
D
V
T
Y
V
Y
--------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
63.60
29%
-27
- C1 -
-
3C0I
1
CSKP_HUMAN
A:
[23-293]
--------------------------------------
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
-
Q
Q
F
A
V
K
I
V
D
V
A
K
F
-
T
S
SP---
G
L
S
T
E
D
L
K
R
E
A
S
I
C
H
M
L
-
K
H
P
H
I
V
E
L
-
L
E
T
Y
S
S
D
G
M
-
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
-----
D
-
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
--
S
--
K
ENS
A
---
P
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
S
G
--
L
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
------
R
E
P
-
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
K
E
R
---
L
F
E
G
I
I
K
G
K
----
Y
---
K
M
N
P
R
---
Q
W
S
H
-
I
---
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
-----
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
------------------------------------------------------------------------------------------------------------------------------------------
45
HHSearch
62.66
29%
-21
- C1 -
-
4GV1
5
AKT1_HUMAN
A:
[7-276]
--------------------------------------
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
T
G
-
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
------
K
D
E
V
A
H
T
L
T
E
N
R
V
L
Q
N
S
-
R
H
P
F
L
T
A
L
-
K
Y
S
F
Q
T
H
D
R
-
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
----
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
-----
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
--
K
--
D
---
G
---
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
--
A
T
M
K
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
------
D
N
D
-
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
E
--
K
L
F
E
L
I
L
M
E
E
--------
I
---
R
---
F
P
R
T
-
L
---
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
GGGS
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
62.64
29%
-20
- C1 -
-
3C0G
1
CSKP_HUMAN
B:
[23-294]
--------------------------------------
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
-
Q
Q
F
A
V
K
I
V
D
V
A
K
F
-
T
S
SP---
G
L
S
T
E
D
L
K
R
E
A
S
I
C
H
M
L
-
K
H
P
H
I
V
E
L
-
L
E
T
Y
S
S
D
G
M
-
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
-----
D
-
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
--
S
--
K
ENS
A
---
P
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
S
G
--
L
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
------
R
E
P
-
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
K
E
R
---
L
F
E
G
I
I
K
G
K
----
Y
---
K
MNP
R
---
Q
W
S
H
-
I
---
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
-----
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
-----------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
61.99
34%
-45
- C1 -
-
2WQM
-
NEK7_HUMAN
A:
[20-289]
---------------------------
K
A
L
R
P
D
M
G
Y
N
T
L
A
N
F
R
I
E
K
K
I
G
R
G
--
S
E
V
Y
R
A
A
C
L
L
D
G
V
P
V
A
L
K
K
V
Q
I
F
D
L
M
-
D
------
A
K
A
R
A
D
C
I
K
E
I
D
L
L
K
Q
L
-
N
H
P
N
V
I
K
Y
-
Y
A
S
F
I
E
D
N
E
-
L
N
I
V
L
E
L
A
D
A
G
D
L
S
R
M
I
K
H
F
K
K
Q
K
R
L
I
P
E
R
T
V
W
K
Y
F
V
Q
L
C
S
A
L
E
H
M
H
-----
S
-
R
R
V
M
H
R
D
I
K
P
A
N
V
F
I
T
--
A
--
T
---
G
---
V
V
K
L
G
D
L
--------------------
T
P
Y
Y
M
S
P
E
R
I
H
------
E
N
G
-
Y
N
F
K
S
D
I
W
S
L
G
C
L
L
Y
E
M
A
A
L
Q
S
P
F
Y
---
M
N
L
Y
S
L
C
K
K
I
E
Q
C
D
----
Y
---
P
---
P
---
L
P
S
D
H
Y
---
S
E
E
L
R
Q
L
V
N
M
C
I
N
P
D
P
E
K
R
P
-----
D
V
T
Y
V
Y
--------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
61.48
36%
-17
- C1 -
-
5M51
1
NEK2_HUMAN
A:
[14-271]
-----------------------------------------------
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
S
D
G
-
K
I
L
V
W
K
E
L
D
Y
G
S
M
-
T
------
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
-
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
RSDG
G
-
H
T
V
L
H
R
D
L
K
P
A
N
V
F
L
D
--
G
--
K
---
Q
---
N
V
K
L
G
D
F
------------------
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
------
R
M
S
-
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
--
E
L
A
G
K
I
R
E
G
K
----
F
---
R
---
R
---
I
P
Y
R
-
Y
---
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
-----
S
V
E
E
I
L
E
N
P
L
I
---------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
59.21
36%
-21
- C1 -
-
2XNO
13
NEK2_HUMAN
A:
[14-271]
-----------------------------------------------
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
S
D
G
-
K
I
L
V
W
K
E
L
D
Y
G
S
M
-
T
------
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
-
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S---------
R
D
L
K
P
A
N
V
F
L
D
--
G
--
K
---
Q
---
N
V
K
L
G
D
F
-----------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
------
R
----
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
--
E
L
A
G
K
I
R
E
G
K
----
F
---
R
---
R
---
I
P
Y
R
-
Y
---
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
-----
S
V
E
E
I
L
E
N
P
L
I
---------------------------------------------------------------------------------------------------------------------------------------------