@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_31_3300: (2018-03-12 )
MSAFSSVLGAPGATGDVKYVKKKLIGTGSYGEAWLVERASDKAIFVAKTMDLGKMSSRDRTYAYSEIKCLASCHHPNIIKYIEDKEDNEHLLIVMEFADSGDLDRQIKARATDFKHFQEHEALFLFLQLCLALDHIHGHKMLHRDIKGANVLLTSTGLIKIGDFGFSHQYDDTVSGVVANTFCGTPYYLAPELWNNQRYSKKADVWSLGVLLYEIMALKRPFTSTNMKGLMAKVLSGDYEPLPEVYSADFRDVVRKILVCDAAQRPSVRDIFRFPYVREGLKVFMHTMKKNSRIDNEVKDALMEHVTEILSSESVEVPKSTPVGQINKDVFFSGYLNKLKGGDNHSWKRRYLQVQKGHFIMSDKESDTEGKALSLEHIQSVCPVPVSTAKREHVFALHTTSGKSMWFEAASLENMEEWIHAIQCGLGVA
Atome Classification :
(20 SA)
.........10........20........30........40........50.....---...60........70........80......--..90........100.......110.......120.......130.....-----..140.......150...--.---...160.......170.......180.......190......----.-200.......210.......220.......230.......240-.---.....---...250.......260..--.....270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
S
A
F
S
S
V
LGAPGATG
D
V
K
Y
V
K
K
K
LIGTGSYGE
A
W
L
V
ERASD
K
A
I
F
V
A
K
TMDLGKMS---SRDR
T
Y
A
Y
S
E
I
K
C
L
A
SCHHP
N
I
I
K
Y
IEDKED--NE
H
L
L
I
V
M
E
FADSGDL
D
R
Q
I
K
A
RAT
D
F
K
H
F
Q
E
H
E
A
L
F
L
F
L
Q
L
C
L
A
L
D
H
IH-----G
H
K
M
L
H
R
DIKGA
N
V
L
L
TS--T---
G
L
I
K
I
GDFGFSHQYDD
T
V
S
G
V
V
A
NTFCGTP
Y
Y
L
A
P
E
LWNNQR----Y-SKKA
D
V
W
S
L
G
V
L
L
Y
E
I
M
A
LKRPFTST
N
M
K
G
L
M
A
K
V
LSGDYE---P---
L
P
E
V
Y
---
S
A
D
F
R
D
V
V
R
K
I
L
VCDAAQ--RP
S
V
R
D
I
F
R
F
P
Y
V
R
E
G
L
K
V
F
M
H
T
M
KKNSRI
D
N
E
V
K
D
A
L
M
E
H
V
T
E
I
LSSESVEVPKSTPVGQI
N
K
D
V
F
F
S
G
Y
L
N
KLKGGDN
H
S
W
K
R
R
Y
L
Q
VQKG
H
F
I
MSDKESDTEG
K
A
L
S
L
E
H
I
Q
S
VCPVPVSTAKR
E
H
V
F
A
L
HTTSGK
S
M
W
F
E
A
A
S
L
E
N
M
E
E
W
I
H
A
I
Q
CGLGVA
1
PsiBlast_PDB
90.87
39%
-149
- C1 -
-
4APC
-
NEK1_HUMAN
A:
[25-288]
-----------------
K
Y
V
R
L
Q
K
I
------
K
A
I
L
V
K
S
T
E
D
G
R
Q
Y
V
I
K
E
I
N
I
S
R
M
S
---
S
K
E
R
E
E
S
R
R
E
V
A
V
L
A
N
M
K
H
P
N
I
V
Q
Y
R
E
S
F
E
E
--
N
G
S
L
Y
I
V
M
D
Y
C
E
G
G
D
L
F
K
R
I
N
A
Q
K
G
V
L
--
F
Q
E
D
Q
I
L
D
W
F
V
Q
I
C
L
A
L
K
H
V
H
-----
D
R
K
I
L
H
R
D
I
K
S
Q
N
I
F
L
T
K
--
D
---
G
T
V
Q
L
G
D
F
G
I
A
R
V
L
N
S
T
V
E
--
L
A
R
A
C
I
G
T
P
Y
Y
L
S
P
E
I
C
E
N
K
P
----
Y
-
N
N
K
S
D
I
W
A
L
G
C
V
L
Y
E
L
C
T
L
K
H
A
F
E
A
G
S
M
K
N
L
V
L
K
I
I
S
G
S
F
P
---
P
---
V
S
L
H
Y
---
S
Y
D
L
R
S
L
V
S
Q
L
F
K
R
N
P
R
D
--
R
P
S
V
N
S
I
L
E
K
G
F
I
A
K
R
I
E
K
F
L
------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
90.21
39%
-148
- C1 -
-
4B9D
1
NEK1_HUMAN
A:
[25-288]
-----------------
K
Y
V
R
L
Q
K
I
------
K
A
I
L
V
K
S
T
E
D
G
R
Q
Y
V
I
K
E
I
N
I
S
R
M
S
---
S
K
E
R
E
E
S
R
R
E
V
A
V
L
A
N
M
K
H
P
N
I
V
Q
Y
R
E
S
F
E
E
--
N
G
S
L
Y
I
V
M
D
Y
C
E
G
G
D
L
F
K
R
I
N
A
Q
K
G
V
L
--
F
Q
E
D
Q
I
L
D
W
F
V
Q
I
C
L
A
L
K
H
V
H
-----
D
R
K
I
L
H
R
D
I
K
S
Q
N
I
F
L
T
K
--
D
---
G
T
V
Q
L
G
D
F
G
I
A
R
V
L
N
S
T
V
E
--
L
A
R
A
C
I
G
T
P
Y
Y
L
S
P
E
I
C
E
N
K
P
----
Y
-
N
N
K
S
D
I
W
A
L
G
C
V
L
Y
E
L
C
T
L
K
H
A
F
E
A
G
S
M
K
N
L
V
L
K
I
I
S
G
S
F
P
---
P
---
V
S
L
H
Y
---
S
Y
D
L
R
S
L
V
S
Q
L
F
K
R
N
P
R
D
--
R
P
S
V
N
S
I
L
E
K
G
F
I
A
K
R
I
E
K
F
L
------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
72.96
38%
-38
- C1 -
-
2W5A
5
NEK2_HUMAN
A:
[14-273]
------------------------
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
T
---
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
RT
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S------
L
H
R
D
L
K
P
A
N
V
F
L
D
G
--
K
---
Q
N
V
K
L
G
D
F
G
L
A
R
I
L
---
T
S
--
F
A
K
T
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
M
-----
Y
-
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
F
R
---
R
---
I
P
Y
R
Y
---
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
--
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
72.52
32%
-90
- C1 -
-
2QNJ
-
MARK3_HUMAN
A:
[60-310]
----------------------
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
R
E
V
A
I
K
I
I
D
K
T
Q
L
N
---
P
T
S
L
Q
K
L
F
R
E
V
R
I
M
K
I
L
N
H
P
N
I
V
K
L
F
E
V
I
E
T
--
E
K
T
L
Y
L
I
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
----
R
M
K
E
K
E
A
R
S
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
-----
Q
K
R
I
V
H
R
D
L
K
A
E
N
L
L
L
D
A
--
D
---
M
N
I
K
I
A
D
F
G
F
S
N
E
F
--
T
------
D
T
F
C
G
S
P
P
Y
A
A
P
E
L
F
Q
G
K
K
----
Y
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
Q
N
L
K
E
L
R
E
R
V
L
R
G
K
Y
R
-------
I
P
F
Y
M
---
S
T
D
C
E
N
L
L
K
R
F
L
V
L
N
P
I
K
--
R
G
T
L
E
Q
I
M
K
D
R
W
I
N
A
G
-----------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
72.42
29%
-45
- C1 -
-
4WOT
1
ROCK2_HUMAN
B:
[68-338]
---------------
A
E
D
Y
D
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
A
S
Q
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
--
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
A
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
--
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
-----
D
V
P
E
K
W
A
K
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
-----
S
M
G
L
I
H
R
D
V
K
P
D
N
M
L
L
D
K
--
H
---
G
H
L
K
L
A
D
F
G
T
C
M
K
M
D
E
T
G
-
M
V
H
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
G
GDGF
Y
-
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
D
H
K
N
S
LCF
P
---
E
D
A
E
I
---
S
K
H
A
K
N
L
I
C
A
F
L
T
D
R
E
V
R
LG
R
N
G
V
E
E
I
R
Q
H
P
F
F
K
N
D
-----------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
71.88
38%
-26
- C1 -
-
2W5B
1
NEK2_HUMAN
A:
[14-273]
------------------------
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
T
---
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
RT
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S------
L
H
R
D
L
K
P
A
N
V
F
L
D
G
--
K
---
Q
N
V
K
L
G
D
F
G
L
A
R
I
L
N
H
D
T
S
--
F
A
K
A
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
M
S
----
Y
-
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
F
R
---
R
---
I
P
Y
R
Y
---
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
--
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
70.97
31%
-109
- C1 -
-
5ES1
1
MARK4_HUMAN
A:
[21-271]
----------------------
R
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
R
E
V
A
I
K
I
I
D
K
T
Q
L
N
---
P
S
S
L
Q
K
L
F
R
E
V
R
I
M
K
G
L
N
H
P
N
I
V
K
L
F
E
V
I
E
T
--
E
K
T
L
Y
L
V
M
E
Y
A
S
A
G
E
V
F
D
Y
L
V
S
H
G
----
R
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
H
Y
C
H
-----
Q
K
N
I
V
H
R
D
L
K
A
E
N
L
L
L
D
A
--
E
---
A
N
I
K
I
A
D
F
G
F
S
N
----------------
S
P
P
Y
A
A
P
E
L
F
Q
G
K
K
----
Y
D
G
P
E
V
D
I
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
H
N
L
K
E
L
R
E
R
V
L
R
G
K
Y
R
-------
V
P
F
Y
M
---
S
T
D
C
E
S
I
L
R
R
F
L
V
L
N
P
A
K
--
R
C
T
L
E
Q
I
M
K
D
K
W
I
N
I
G
-----------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
70.19
38%
-22
- C1 -
-
5M51
1
NEK2_HUMAN
A:
[14-273]
------------------------
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
T
---
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
RT
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
RSDG
G
H
T
V
L
H
R
D
L
K
P
A
N
V
F
L
D
G
--
K
---
Q
N
V
K
L
G
D
F
------------------
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
M
S
----
Y
-
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
F
R
---
R
---
I
P
Y
R
Y
---
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
--
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
70.16
38%
-27
- C1 -
-
5M57
1
NEK2_HUMAN
A:
[14-273]
------------------------
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
T
---
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
RT
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
RRSDG
G
H
T
V
L
H
R
D
L
K
P
A
N
V
F
L
D
G
--
K
---
Q
N
V
K
L
G
D
F
------------------
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
M
S
----
Y
-
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
F
R
---
R
---
I
P
Y
R
Y
---
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
--
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
69.23
38%
-76
- C1 -
-
2JAV
1
NEK2_HUMAN
A:
[14-273]
------------------------
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
T
---
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
----
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
SD---------
L
K
P
A
N
V
F
L
D
G
--
K
---
Q
N
V
K
L
G
D
F
G
L
A
R
I
L
-------------
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
M
S
----
Y
-
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
F
R
---
R
---
I
P
Y
R
Y
---
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
--
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
68.13
32%
-99
- C- -
-
2R0I
-
MARK2_RAT
A:
[57-300]
----------------------
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
I
D
K
T
Q
L
N
---
S
S
S
L
Q
K
L
F
R
E
V
R
I
M
K
V
L
N
H
P
N
I
V
K
L
F
E
V
I
E
T
--
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
----
R
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
-----
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
D
A
--
D
---
M
N
I
K
I
A
D
F
-------------------
G
S
P
P
Y
A
A
P
E
L
F
Q
G
K
K
----
Y
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
Q
N
L
K
E
L
R
E
R
V
L
R
G
K
Y
R
-------
I
P
F
Y
M
---
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
--
R
G
T
L
E
Q
I
M
K
------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
67.78
38%
-26
- C1 -
-
2XNM
10
NEK2_HUMAN
A:
[14-273]
------------------------
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
T
---
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
RT
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R---------
R
D
L
K
P
A
N
V
F
L
D
G
--
K
---
Q
N
V
K
L
G
D
F
G
L
A
R
I
L
-----------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
-
S
----
Y
-
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
F
R
---
R
---
I
P
Y
R
Y
---
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
--
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
66.79
27%
-86
- C1 -
-
4XBR
1
INKA1_HUMAN (first)
A:
[93-350]
---------------
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
Q
-----
Q
R
R
E
L
L
F
N
E
V
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
T
-----
R
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
-----
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
--
D
---
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
--
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
R
L
P
----
Y
-
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
RL-
K
---
N
L
H
K
V
---
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
--
R
A
T
A
A
E
L
L
K
H
P
F
L
A
K
A
-----------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
66.77
32%
-93
- C1 -
-
5EAK
1
MARK2_HUMAN
A:
[21-264]
----------------------
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
I
D
K
T
Q
L
N
---
S
S
S
L
Q
K
L
F
R
E
V
R
I
M
K
V
L
N
H
P
N
I
V
K
L
F
E
V
I
E
T
--
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
----
R
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
-----
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
D
A
--
D
---
M
N
I
K
I
A
D
F
G
F
S
--------------
F
C
G
S
P
P
Y
A
A
P
E
L
F
Q
G
K
K
----
Y
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
Q
N
L
K
E
L
R
E
R
V
L
R
G
K
Y
R
-------
I
P
F
Y
M
---
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
--
R
G
T
L
E
Q
I
M
K
------------------------------------------------------------------------------------------------------------------------------------------------------------
45
Fugue
66.05
24%
-46
- C1 -
-
1TKI
-
TITIN_HUMAN
A:
[18-338]
------------
K
E
L
Y
E
K
Y
M
I
A
E
D
L
G
R
G
E
F
G
I
V
H
R
C
V
E
T
S
S
K
K
T
Y
M
A
K
F
V
---
K
V
K
---
G
T
D
Q
V
L
V
K
K
E
I
S
I
L
N
I
A
R
H
R
N
I
L
H
L
H
E
S
F
E
S
--
M
E
E
L
V
M
I
F
E
F
I
S
G
L
D
I
F
E
R
I
N
T
S
A
F
E
L
---
N
E
R
E
I
V
S
Y
V
H
Q
V
C
E
A
L
Q
F
L
H
-----
S
H
N
I
G
H
F
D
I
R
P
E
N
I
I
Y
Q
T
RR
S
---
S
T
I
K
I
I
E
F
G
Q
A
R
Q
L
K
P
---
G
D
N
F
R
L
L
F
T
A
P
E
Y
Y
A
P
E
V
H
Q
H
D
V
----
V
-
S
T
A
T
D
M
W
S
L
G
T
L
V
Y
V
L
L
S
G
I
N
P
F
L
A
E
T
N
Q
Q
I
I
E
N
I
M
N
A
E
Y
T
---
F
---
D
E
E
A
F
KEI
S
I
E
A
M
D
F
V
D
R
L
L
V
K
E
R
K
S
--
R
M
T
A
S
E
A
L
Q
H
P
W
L
K
Q
K
I
E
R
V
S
T
K
V
I
R
T
L
K
H
R
R
Y
Y
H
T
L
I
---------------
K
K
D
L
N
M
V
V
S
A
A
R
I
S
C
G
G
A
I
R
S
Q
K
G
-------------------------------------
V
S
V
A
K
V
K
V
A
S
I
----------------------------------------
28
HHSearch
64.71
29%
-35
- C1 -
-
3C0G
1
CSKP_HUMAN
B:
[22-293]
--------------
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
SP
G
L
S
T
E
D
L
K
R
E
A
S
I
C
H
M
L
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
--
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
-----
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
--
K
ENS
A
P
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
S
--
G
L
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
R
E
P
----
Y
-
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
K
E
R
-
L
F
E
G
I
I
K
G
K
Y
K
---
M
NPR
Q
W
S
H
I
---
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
--
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
-----------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
64.35
27%
-112
- C1 -
-
5K00
1
MELK_HUMAN
A:
[6-265]
--------------
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
--
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
N
T
L
----
G
S
D
L
P
R
I
K
T
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
--
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
----
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
-----
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
--
Y
---
H
K
L
K
L
I
D
F
G
L
C
A
K
P
--------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
S
Y---
L
-
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
K
Y
----
D
---
V
P
K
W
L
---
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
--
R
I
S
M
K
N
L
L
N
H
P
W
I
M
Q
D
-----------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
64.13
38%
-23
- C1 -
-
2XNO
13
NEK2_HUMAN
A:
[14-273]
------------------------
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
T
---
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
RT
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S--------
R
D
L
K
P
A
N
V
F
L
D
G
--
K
---
Q
N
V
K
L
G
D
F
-----------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
--------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
F
R
---
R
---
I
P
Y
R
Y
---
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
--
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
63.80
29%
-41
- C1 -
-
3C0I
1
CSKP_HUMAN
A:
[22-293]
--------------
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
SP
G
L
S
T
E
D
L
K
R
E
A
S
I
C
H
M
L
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
--
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
-----
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
--
K
ENS
A
P
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
S
G
--
L
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
R
E
P
----
Y
-
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
K
E
R
-
L
F
E
G
I
I
K
G
K
Y
K
---
M
N
PR
Q
W
S
H
I
---
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
--
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
-----------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
63.69
32%
-101
- C1 -
-
1ZMU
-
MARK2_RAT
A:
[57-300]
----------------------
K
T
I
G
K
G
--
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
I
D
K
T
Q
L
N
---
S
S
S
L
Q
K
L
F
R
E
V
R
I
M
K
V
L
N
H
P
N
I
V
K
L
F
E
V
I
E
T
--
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
----
R
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
-----
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
D
A
--
D
---
M
N
I
K
I
A
---------------------
G
S
P
P
Y
A
A
P
E
L
F
Q
G
K
K
----
Y
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
Q
N
L
K
E
L
R
E
R
V
L
R
G
K
Y
R
-------
I
P
F
Y
M
---
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
--
R
G
T
L
E
Q
I
M
K
------------------------------------------------------------------------------------------------------------------------------------------------------------