@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_32_0860: (2018-03-12 )
MIRNATIPAYIQSSPNHSNHNNMSLSLSLQKQKDANADGEDYADGRRILMHNPLKGHLFSSTSDSSLHSSIGQPEMIAAASSSVQKGSSGAGNRLDTALGFCGEETAQGLVAEQVEGPCDEKHVNLIEVRAIDSDDDPSSLEEQEHQVCCTIPSLPAVAFIMCFGAIIVGLLGFLPFYFVGVQSNAHTTEYLLSEAMKGVASITQNSLAMLPAFVHIVTFNYIKRHNTTLEETNLPQDPDQLLVSLLTVLTRFNEAISYLRFVYEGGLYTNAGYTDPKPTDANQTRKIYGGYSRTHNTVPMLEMYNESVTAVEPPNVLGYFDFHREVTLPEGAMNQIVKTWVADPQNNTRWLLASDNTTPTYFNFVMPFTVNGSLGYFAAGSSSDTIIEETTTLVSFLRKNGRIFLVDATRNIVVGNSWNQSVQSRTEDSAIGATIYTPTRIYEITEPIILAAMQVVNESGSLTEVLKDKDTALITFRYKGNNAFLNLTKVKDSYGLDLVLGVVVVRADFEKAFSTARTAAFTVTVLVVVIAAVVAVVIAWFVVREMKRLIPQLIRASNLEVSRGDGKDHRVQGWLAYITEIRGIHEAFVRVERSLREMRTFVPAAVMTLAPSDGSHSDADLADGKTRRVRTRFNANIVKDNTNEFSRVDVAMVLVDVHRAMDTTEACFIMDIISQRAEEYTGYIESVSSSSFFVNFGTQSQNPLVVSKICRFALEVYQSVPDFMRNRVVCFAVRMPFLVGTCGARHSKARVVFDTQRMLDISKVLWDIGCHVASTTDTLSHFATSSAQIPWYRIDCVRFPDEVSQVTLCELRDPRSSLQDNEDMPKKMGDGLSKMCKGEYKQALMIFDSAHSENVQLKRLRKICIDRIASGDTSKYIHLIQDVYALDATPSNHEDMAVGGGAAMYDYDAGSPAGVATSSGEVCDPSNEPPLLACSSFENGAGMPAPVLSQPAAHASPPVAPHTTPICHSKTSPTPSVTTGGEAAEPSHLTERAVTAAMGPREFPPCGASQVVGASGAGPGLPPFHPRTPGATTTAASVPGSSPPWGARDDNASEAPSFLTNAFVFDSSMASADAVGATVQAADEPQVLRDVNQHEWQVSLYPIGSGAFSFIYLGMSDDGVQVAIKRIPRLHRGIKEEEMVSEVCTCAKLRHPNIVPYISCCVTQSYLAIIMEYMPGGSLHDIIDNFGKLPRTVVRRFMLDIVNGLAYLHESTTHGDVKPHNILLGVDGVCKLSDFGSASDRLTEACCVNEDRLMRGTAVYISPEGARNLPLTSASDIYSLGISFLEMVLGRLPWKWADPESTDELPLRHDHEFVQCLTANAIVVDIPDDLDNDMRELALASCAENPEKRPTAQELLSFAFLI
Atome Classification :
(21 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970....--------...980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080.....--.1090......1100......1110...-.-.-.1120.....--.1130--.......1140......1150......1160...----...1170......1180...--------.--------..--1190......1200......1210.--..-.....1220......1230....--..---1240....--..1250...-...1260......-1270-........1280......1290......1300......1310......1320......1330......1340..-....1350--.........1360------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MIRNATI
P
A
Y
IQSSPNHSNHN
N
M
S
L
S
L
S
L
Q
KQKDANADGEDYADG
R
R
I
L
M
HNPLK
G
H
L
FSSTSD
S
S
L
H
SSIGQP
E
M
I
A
AASSSVQKGSSGAGN
R
L
D
T
A
LGFC
G
E
E
T
A
Q
G
L
V
A
E
QVEGPCDEK
H
V
N
L
I
E
V
R
AIDSDDDP
S
S
L
E
E
Q
E
H
Q
V
C
CTIPS
L
P
A
V
A
F
I
M
C
F
G
A
I
I
V
G
L
L
G
F
L
P
F
Y
F
VGVQSNA
H
T
T
E
Y
L
L
S
E
A
M
K
G
V
A
S
I
T
Q
N
S
L
A
M
L
P
A
F
V
H
I
V
T
F
N
Y
I
K
RHNTTLEETNLPQ
D
P
D
Q
L
L
V
S
L
L
T
V
L
T
R
F
N
E
A
I
S
Y
L
R
F
V
YEGGLYTNAGYTDPKPTDANQ
T
R
K
I
YGGYSRTHNT
V
P
M
L
E
MYNESVTAVEPP
N
V
L
G
Y
F
D
FHREVTLP
E
G
A
M
N
Q
I
V
K
T
W
VADPQNN
T
R
W
L
L
ASDNTT
P
T
Y
F
N
F
V
M
P
F
T
VNGSL
G
Y
F
AAGSSSD
T
I
I
E
E
T
T
T
L
V
S
F
L
RKN
G
R
I
F
L
V
DATR
N
I
V
VGNSW
N
Q
S
V
Q
SRTEDSAI
G
A
T
IYTP
T
R
I
Y
E
I
T
E
P
I
I
L
A
A
M
Q
V
V
NESG
S
L
T
E
V
LKDKD
T
A
L
I
T
F
R
YKGN
N
A
F
L
N
L
T
KVKDSYG
L
D
L
V
L
G
V
V
V
V
R
A
D
F
E
K
A
F
S
TART
A
A
F
T
V
T
V
L
V
V
V
I
A
A
V
V
A
V
V
I
A
W
F
V
V
R
E
M
K
R
L
I
P
Q
L
I
R
ASN
L
E
VSRGDGK
D
H
R
V
Q
G
W
L
A
Y
I
T
E
I
R
G
I
H
E
A
F
V
R
V
E
R
S
L
R
E
M
R
T
F
V
P
A
A
V
M
T
LAPSDGSHSDADLADGK
T
R
R
V
R
T
R
FN
A
N
I
VKDNTNEF
S
R
V
D
V
A
M
V
L
V
D
V
H
R
AMDT
T
E
A
C
F
I
M
D
I
I
S
Q
R
A
E
E
Y
T
G
Y
I
E
SVSSS
S
F
F
V
N
FGTQSQN
P
L
V
V
S
K
I
C
R
F
A
L
E
V
Y
Q
S
V
P
D
F
M
RN
R
V
V
C
F
A
VRM
P
F
L
V
GTCGARHS
K
A
R
V
V
F
D
T
Q
R
M
L
D
I
S
K
V
L
W
D
IGCHVAS
T
T
D
T
L
S
H
FATSSAQI
P
W
Y
R
I
D
C
VRFPDEVS
Q
V
T
L
C
E
LRDPRSSLQDNE
D
M
P
K
K
M
G
D
G
L
S
K
M
C
K
G
E
Y
K
Q
A
L
M
I
F
DSAHSE
N
V
Q
L
K
R
L
R
K
I
C
I
D
R
IASGD
T
S
K
Y
I
H
L
I
Q
D
V
Y
ALDATPSNHEDMAVGG
G
A
A
M
Y
DYDAGSPAGVATSSGEVCDPSNEP
P
L
L
A
C
SSFENGAGMPAPVLSQPAAHASPPVAPHTTPICHSKTSPTP--------SVTTGGEAAE
P
S
H
L
T
E
R
A
V
T
AAMGPREFPPCGAS
Q
V
VGASGAGPGLPPFHPRTPGATTTAASVPGSSPPWGARDDNASE
A
P
S
F
L
T
N
A
F
V
FDSSMASADAVG
A
T
VQAAD
E
P
Q
V
--
L
R
DVNQH
E
W
Q
V
S
L
Y
P
IGSG
A
F
S
F
I
Y
LGM-S-D-D
G
V
Q
V
A
I
K
R
I
--
P
R
L
H---RGI
K
E
E
E
M
V
S
E
V
C
T
C
A
KLRHPNI
V
P
Y
I
S
C
C
V
T
Q
S
----
Y
L
A
I
I
M
E
YMPGG
S
L
H
D
I
I
D
N
--------
F
--------
G
K
--
L
P
R
T
V
V
R
R
F
M
L
D
I
V
N
G
L
A
Y
L
H-E-S--TT-HGDVKP
H
N
I
L
L
GVDG
V
C
KLSDFG--S
A
---
S
D
R
L
T
E
A
C--CV
N
E
D
RLMR-G
T
A
V
Y
ISPEGARN-L--P-LT
S
A
S
D
I
Y
S
L
G
I
S
F
L
E
M
V
L
G
RLPWKWADPESTDELPLRH
D
H
E
F
V
Q
C
L
TA
N
A
I
V
V
DIPDD
L
D
N
D
M
R
E
L
A
L
A
S
CAE-NPEKR-----
P
T
A
Q
E
L
L
S
F
A
FLI------------------------------------------------------------------
53
Fugue
78.48
23%
-60
- C1 -
-
5KCV
1
AKT1_HUMAN
A:
[20-452]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
K
E
G
W
L
H
K
R
G
E
Y
I
T
W
R
P
R
Y
F
L
L
K
N
D
G
T
F
I
G
Y
K
E
R
P
A
P
L
N
N
F
S
V
A
Q
C
Q
L
M
K
T
E
R
P
R
P
N
----------------
T
F
I
I
R
C
L
Q
W
T
T
V
I
E
R
T
F
H
V
E
T
P
E
E
R
E
E
W
T
T
A
--
I
Q
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
-
K
-
A
-
T
G
R
Y
Y
A
M
K
I
L
--
K
K
V
L
---
Q
---------------
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
----
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--------
E
--------
R
V
--
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
-
S
-
E
KN
V
V
-
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
--
L
C
---
P
E
----------------------
Y
L
A
P
E
V
L
E
D
-
N
--
D
-
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
E
K
L
F
E
L
I
L
M
E
E
I
R
F
-------------
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
-
D
P
K
Q
R
LGGGS
E
D
A
K
E
I
M
Q
H
R
F
F
A
GIV
W
Q
H
V
Y
E
KKLSPPFKPQVTSETDTRYF-------------------------------------
16
PsiBlast_PDB
73.60
26%
-99
- C1 -
-
5CEP
1
M3K12_HUMAN
A:
[15-250]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
L
Q
W
V
G
S
G
A
Q
G
A
V
F
L
G
R
-
F
-
H
--
G
E
E
V
A
V
K
K
V
---------
R
D
L
K
E
----
T
D
I
K
H
L
R
K
L
K
H
P
N
I
I
T
F
K
G
V
C
T
Q
A
P
----
C
Y
C
I
L
M
E
F
C
A
Q
G
Q
L
Y
E
V
L
R
A
--------
G
--------
R
P
--
V
T
P
S
L
L
V
D
W
S
M
G
I
A
G
G
M
N
Y
L
H
L
H
-
K
--
I
I
-
H
R
D
L
K
S
P
N
M
L
I
T
Y
D
D
V
V
K
I
S
D
F
G
------------------------
F
A
-
G
T
V
A
W
M
A
P
E
V
I
R
N
-
E
--
P
-
V
S
E
K
V
D
I
W
S
F
G
V
V
L
W
E
L
L
T
G
E
I
P
Y
K
D
V
D
S
S
A
-----------
I
I
W
G
V
G
S
N
S
L
H
L
P
V
P
S
S
C
P
D
G
F
K
I
L
L
R
Q
C
W
N
S
-
K
P
R
N
R
-----
P
S
F
R
Q
I
L
------------------------------------------------------------------------
15
PsiBlast_PDB
71.61
26%
-105
- C1 -
-
5CEO
1
M3K12_HUMAN
A:
[15-250]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
L
Q
W
V
G
S
G
A
Q
G
A
V
F
L
G
R
-
F
-
H
--
G
E
E
V
A
V
K
K
V
---------
R
D
L
K
E
----
T
D
I
K
H
L
R
K
L
K
H
P
N
I
I
T
F
K
G
V
C
T
Q
A
P
----
C
Y
C
I
L
M
E
F
C
A
Q
G
Q
L
Y
E
V
L
R
A
--------
G
--------
R
P
--
V
T
P
S
L
L
V
D
W
S
M
G
I
A
G
G
M
N
Y
L
H
L
H
-
K
--
I
I
-
H
R
D
L
K
S
P
N
M
L
I
T
Y
D
D
V
V
K
I
S
D
F
G
------------------------
F
A
-
G
T
V
A
W
M
A
P
E
V
I
R
N
-
E
--
P
-
V
S
E
K
V
D
I
W
S
F
G
V
V
L
W
E
L
L
T
G
E
I
P
Y
K
D
V
D
S
S
A
-----------
I
I
W
G
V
G
S
N
S
L
H
L
P
V
P
S
S
C
P
D
G
F
K
I
L
L
R
Q
C
W
N
S
-
K
P
R
N
R
-----
P
S
F
R
Q
I
L
------------------------------------------------------------------------
17
PsiBlast_PDB
70.56
26%
-97
- C1 -
-
5CEQ
1
M3K12_HUMAN
A:
[15-250]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
L
Q
W
V
G
S
G
A
Q
G
A
V
F
L
G
R
-
F
-
H
--
G
E
E
V
A
V
K
K
V
---------
R
D
L
K
E
----
T
D
I
K
H
L
R
K
L
K
H
P
N
I
I
T
F
K
G
V
C
T
Q
A
P
----
C
Y
C
I
L
M
E
F
C
A
Q
G
Q
L
Y
E
V
L
R
A
--------
G
--------
R
P
--
V
T
P
S
L
L
V
D
W
S
M
G
I
A
G
G
M
N
Y
L
H
L
H
-
K
--
I
I
-
H
R
D
L
K
S
P
N
M
L
I
T
Y
D
D
V
V
K
I
S
D
F
G
------------------------
F
A
-
G
T
V
A
W
M
A
P
E
V
I
R
N
-
E
--
P
-
V
S
E
K
V
D
I
W
S
F
G
V
V
L
W
E
L
L
T
G
E
I
P
Y
K
D
V
D
S
S
A
-----------
I
I
W
G
V
G
S
N
S
L
H
L
P
V
P
S
S
C
P
D
G
F
K
I
L
L
R
Q
C
W
N
S
-
K
P
R
N
R
-----
P
S
F
R
Q
I
L
------------------------------------------------------------------------
51
Fugue
70.28
19%
-17
- C1 -
-
4BTF
2
MLKL_MOUSE
A:
[7-460]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
L
G
Q
I
I
K
L
G
Q
L
I
Y
E
Q
C
E
K
M
K
Y
C
R
K
Q
C
Q
R
L
G
N
R
V
H
G
L
L
Q
P
L
Q
R
L
Q
A
Q
G
K
K
--------
N
L
P
D
D
I
T
A
A
L
-
G
R
F
D
E
V
L
K
E
A
N
Q
Q
I
E
K
F
I
L
---------------
F
H
E
V
N
E
K
L
R
D
V
W
E
E
L
L
L
L
L
Q
V
P
A
S
W
Q
Q
E
D
R
Q
D
A
E
E
D
G
N
E
N
M
K
V
I
L
M
Q
L
Q
I
S
V
E
E
I
N
K
T
L
K
Q
C
S
I
P
Q
D
L
Q
I
K
E
I
P
K
E
H
L
G
P
P
W
T
K
L
K
T
S
K
M
S
T
I
Y
R
G
E
-
Y
-
H
--
R
S
P
V
T
I
K
V
F
--
N
N
P
Q
AES
V
G
I
V
R
F
T
F
N
D
E
I
K
T
M
K
K
F
D
S
P
N
I
L
R
I
F
G
I
C
I
D
Q
T
VKP
P
E
F
S
I
V
M
E
Y
C
E
L
G
T
L
R
E
L
L
D
R
--------
E
--------
K
D
--
L
T
M
S
V
R
S
L
L
V
L
R
A
A
R
G
L
Y
R
L
H
-
H
-
S
E-
T
L
-
H
R
N
I
S
S
S
S
F
L
V
A
G
G
Y
Q
V
K
L
A
G
F
E
L
S
K
T
---
Q
N
S
I
S
R
T
-----------
A
-
S
S
T
I
Y
V
S
P
E
R
L
K
N
-
P
FC
L
-
Y
D
I
K
A
E
I
Y
S
F
G
I
V
L
W
E
I
A
T
G
K
I
P
F
E
G
C
D
S
K
K
I
R
E
L
V
A
E
D
K
K
Q
-----------
E
P
V
G
Q
D
C
P
E
L
L
R
E
I
I
N
E
C
R
A
H
-
E
P
S
Q
R
-----
P
S
V
D
G
I
L
E
R
L
S
A
-------------------------------------------------------------------
14
PsiBlast_PDB
69.90
26%
-81
- C- -
-
5CEN
-
M3K12_HUMAN
A:
[126-361]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
L
Q
W
V
G
S
G
A
Q
G
A
V
F
L
G
R
-
F
-
H
--
G
E
E
V
A
V
K
K
V
---------
R
D
L
K
E
----
T
D
I
K
H
L
R
K
L
K
H
P
N
I
I
T
F
K
G
V
C
T
Q
A
P
----
C
Y
C
I
L
M
E
F
C
A
Q
G
Q
L
Y
E
V
L
R
A
--------
G
--------
R
P
--
V
T
P
S
L
L
V
D
W
S
M
G
I
A
G
G
M
N
Y
L
H
L
H
-
K
--
I
I
-
H
R
D
L
K
S
P
N
M
L
I
T
Y
D
D
V
V
K
I
S
D
F
G
--
T
S
KEL
S
D
K
S
T
K
M
S
---------
F
A
-
G
T
V
A
W
M
A
P
E
V
I
R
N
-
E
--
P
-
V
S
E
K
V
D
I
W
S
F
G
V
V
L
W
E
L
L
T
G
E
I
P
Y
K
D
V
D
S
S
A
-----------
I
I
W
G
V
G
S
N
S
L
H
L
P
V
P
S
S
C
P
D
G
F
K
I
L
L
R
Q
C
W
N
S
-
K
P
R
N
R
-----
P
S
F
R
Q
I
L
------------------------------------------------------------------------
6
PsiBlast_PDB
68.80
31%
-66
- C1 -
-
5IME
1
PAK1_HUMAN
A:
[28-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
-
D
-----
Q
E
V
A
I
K
Q
M
---
N
L
--------
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
----
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
--------
T
--------
C
---
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
-
S
-
N
--
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
--
F
C
---
A
Q
I
T
P
E
Q
S
--
K
R
S
E
---
M
V
-
G
T
P
Y
W
M
A
P
E
V
V
T
R
-
K
--
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
-------
L
N
E
N
P
L
R
A
L
Y
L
I
A
---
T
N
G
T
P
E
L
Q
N
P
E
K
L
S
A
I
F
R
D
F
-
L
N
R
C
L
E
M
D
V
E
K
R
-----
G
S
A
K
E
L
L
Q
H
Q
F
L
-------------------------------------------------------------------
7
PsiBlast_PDB
67.96
31%
-33
- C1 -
-
5DEY
1
PAK1_HUMAN
A:
[28-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
-
D
V
A
-
T
G
Q
E
V
A
I
K
Q
M
---
N
L
Q
---
Q
Q
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
----
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
--------
T
--------
C
---
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
-
S
-
N
--
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
--
F
C
---
A
Q
I
T
P
E
Q
S
--
K
R
S
E
---
M
V
-
G
T
P
Y
W
M
A
P
E
V
V
T
R
-
K
--
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
-------
L
N
E
N
P
L
R
A
L
Y
L
I
A
---
T
N
G
T
P
E
L
Q
N
P
E
K
L
S
A
I
F
R
D
F
-
L
N
R
C
L
E
M
D
V
E
K
R
-----
G
S
A
K
E
L
L
Q
H
Q
F
L
-------------------------------------------------------------------
35
HHSearch
67.57
30%
-32
- C1 -
-
3DAK
1
OXSR1_HUMAN
D:
[15-287]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
V
I
G
S
G
A
T
A
V
V
Q
A
A
Y
-
C
-
A
P
K
K
E
K
V
A
I
K
R
I
--
N
L
E
K
---
C
Q
T
S
M
D
E
L
L
K
E
I
Q
A
M
S
Q
C
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
K
D
----
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
D
I
I
K
H
I
V
A
K
GEHK
S
--------
G
V
--
L
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
-
K
N
G
--
Q
I
-
H
R
D
V
K
A
G
N
I
L
L
G
E
D
G
S
V
Q
I
A
D
F
G
--
V
S
---
A
F
L
A
T
G
G
D
IT
R
N
-----
F
V
-
G
T
P
C
W
M
A
P
E
V
M
E
Q
V
R
--
G
-
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
P
P
M
K
V
L
M
L
T
L
Q
N
D
---
P
P
S
L
E
T
G
V
Q
D
K
E
M
L
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
-
D
P
E
K
R
-----
P
T
A
A
E
L
L
R
H
K
F
F
Q
------------------------------------------------------------------
11
PsiBlast_PDB
66.89
31%
-34
- C1 -
-
4DAW
-
PAK1_HUMAN
A:
[28-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
-
D
V
A
-
T
G
Q
E
V
A
I
R
Q
M
---
N
L
Q
---
Q
Q
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
----
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
--------
T
--------
C
---
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
-
S
-
N
--
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
--
F
C
---
A
Q
I
T
P
E
Q
-----
S
K
R
S
T
M
V
-
G
T
P
Y
W
M
A
P
E
V
V
T
R
-
K
--
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
-------
L
N
E
N
P
L
R
A
L
Y
L
I
A
---
T
N
G
T
P
E
L
Q
N
P
E
K
L
S
A
I
F
R
D
F
-
L
N
R
C
L
E
M
D
V
E
K
R
-----
G
S
A
K
E
L
L
Q
H
Q
F
L
-------------------------------------------------------------------
8
PsiBlast_PDB
66.79
31%
-33
- C1 -
-
5DEW
1
PAK1_HUMAN
A:
[28-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
-
D
V
A
-
T
G
Q
E
V
A
I
K
Q
M
---
N
L
Q
---
Q
Q
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
----
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
--------
T
--------
C
---
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
-
S
-
N
--
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
--
F
C
---
A
Q
I
T
P
E
Q
S
--
K
R
S
E
---
M
V
-
G
T
P
Y
W
M
A
P
E
V
V
T
R
-
K
--
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
-------
L
N
E
N
P
L
R
A
L
Y
L
I
A
---
T
N
G
T
P
E
L
Q
N
P
E
K
L
S
A
I
F
R
D
F
-
L
N
R
C
L
E
M
D
V
E
K
R
-----
G
S
A
K
E
L
L
Q
H
Q
F
L
-------------------------------------------------------------------
9
PsiBlast_PDB
66.73
31%
-32
- C1 -
-
3FXZ
1
?
A:
[28-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
-
D
V
A
-
T
G
Q
E
V
A
I
R
Q
M
---
N
L
Q
---
Q
Q
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
----
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
--------
T
--------
C
---
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
-
S
-
N
--
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
--
F
C
---
A
Q
I
T
P
E
Q
-----
S
K
R
S
T
M
V
-
G
T
P
Y
W
M
A
P
E
V
V
T
R
-
K
--
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
-------
L
N
E
N
P
L
R
A
L
Y
L
I
A
---
T
N
G
T
P
E
L
Q
N
P
E
K
L
S
A
I
F
R
D
F
-
L
N
R
C
L
E
M
D
V
E
K
R
-----
G
S
A
K
E
L
L
Q
H
Q
F
L
-------------------------------------------------------------------
13
PsiBlast_PDB
66.72
31%
-34
- C1 -
-
4EQC
1
PAK1_HUMAN
A:
[32-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
-
D
V
A
-
T
G
Q
E
V
A
I
R
Q
M
---
N
L
Q
---
Q
Q
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
----
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
--------
T
--------
C
---
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
-
S
-
N
--
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
--
F
C
---
A
Q
I
T
P
E
Q
-----
S
K
R
S
T
M
V
-
G
T
P
Y
W
M
A
P
E
V
V
T
R
-
K
--
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
-------
L
N
E
N
P
L
R
A
L
Y
L
I
A
---
T
N
G
T
P
E
L
Q
N
P
E
K
L
S
A
I
F
R
D
F
-
L
N
R
C
L
E
M
D
V
E
K
R
-----
G
S
A
K
E
L
L
Q
H
Q
F
L
-------------------------------------------------------------------
50
Fugue
66.61
17%
23
- C1 -
-
2ACX
1
GRK6_HUMAN
A:
[14-532]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
R
K
G
K
S
K
K
W
R
Q
M
L
Q
F
P
H
I
S
Q
C
E
E
L
R
L
S
L
E
R
D
Y
H
S
L
C
E
R
N
P
I
G
R
L
L
F
R
E
F
C
A
T
R
P
E
L
S
R
C
V
A
F
L
D
G
V
A
E
Y
E
V
T
P
D
D
K
R
K
A
C
G
R
N
L
T
Q
N
F
L
S
H
T
G
P
D
L
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
E
Q
G
P
C
K
D
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
P
V
-------
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
R
-
A
-
T
G
K
M
Y
A
C
K
K
L
E
K
K
R
I
K
---
K
R
K
G
E
A
M
A
L
N
E
K
Q
I
L
E
K
V
N
S
R
F
V
V
S
L
A
Y
A
Y
E
T
K
D
----
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
--------
M
--------
G
Q
A
G
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
-
R
-
E
R-
I
V
-
Y
R
D
L
K
P
E
N
I
L
L
D
D
H
G
H
I
R
I
S
D
L
G
--
L
A
---
V
H
V
P
E
G
------
Q
T
I
K
G
R
V
-
G
T
V
G
Y
M
A
P
E
V
V
K
N
-
E
--
R
-
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
F
Q
Q
R
K
K
K
-------
I
K
R
E
E
V
E
R
L
V
K
E
V
P
--
E
E
Y
S
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
-
D
P
A
E
R
LGCRG
G
S
A
R
E
V
K
E
H
P
L
F
K
KLN
F
K
R
L
G
A
GMLEPPFKPDPQAIYCE
P
T
D
Q
D
F
Y
Q
K
F
ATGSVP
I
P
W
Q
N
E
M
V
E
T
E
C
F
Q
E
L
N
VFGLDGS
20
PsiBlast_PDB
66.15
31%
-32
- C1 -
-
4ZY5
1
PAK1_HUMAN
A:
[29-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
-
D
V
A
-
T
G
Q
E
V
A
I
K
-----------
Q
Q
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
-------
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
--------
T
--------
C
---
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
-
S
-
N
--
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
--
F
C
---
A
Q
I
T
P
E
Q
-----
S
K
R
S
T
M
V
-
G
T
P
Y
W
M
A
P
E
V
V
T
R
-
K
--
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
-------
L
N
E
N
P
L
R
A
L
Y
L
I
A
---
T
N
G
T
P
E
L
Q
N
P
E
K
L
S
A
I
F
R
D
F
-
L
N
R
C
L
E
M
D
V
E
K
R
-----
G
S
A
K
E
L
L
Q
H
Q
F
L
-------------------------------------------------------------------
1
PsiBlast_PDB
65.72
28%
-48
- C1 -
-
3DAK
1
OXSR1_HUMAN
A:
[18-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
-
P
-
K
K
E
K
V
A
I
K
R
I
--
N
L
E
K
---
C
Q
T
S
M
D
E
L
L
K
E
I
Q
A
M
S
Q
C
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
K
D
----
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
D
I
I
K
H
--------
I
V
A
K
GEHKS
G
V
--
L
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
-
K
-
N
G-
Q
I
-
H
R
D
V
K
A
G
N
I
L
L
G
E
D
G
S
V
Q
I
A
D
F
G
---
V
---
S
A
F
L
A
T
G
G
-----------V
G
T
P
C
W
M
A
P
E
V
M
E
Q
-
V
--
R
G
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
P
P
M
K
V
L
M
L
T
L
Q
N
D
P
P
S
L
E
T
G
V
Q
D
K
---
E
M
L
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
-
D
P
E
K
R
-----
P
T
A
A
E
L
L
R
H
K
F
F
-------------------------------------------------------------------
12
PsiBlast_PDB
65.65
31%
-32
- C1 -
-
5DFP
2
PAK1_HUMAN
A:
[28-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
-
D
V
A
-
T
G
Q
E
V
A
I
R
Q
M
---
N
L
Q
---
Q
Q
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
----
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
--------
T
--------
C
---
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
-
S
-
N
--
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
--
F
C
---
A
Q
I
T
P
E
Q
-----
S
K
R
S
T
M
V
-
G
T
P
Y
W
M
A
P
E
V
V
T
R
-
K
--
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
-------
L
N
E
N
P
L
R
A
L
Y
L
I
A
---
T
N
G
T
P
E
L
Q
N
P
E
K
L
S
A
I
F
R
D
F
-
L
N
R
C
L
E
M
D
V
E
K
R
-----
G
S
A
K
E
L
L
Q
H
Q
F
L
-------------------------------------------------------------------
4
PsiBlast_PDB
65.63
31%
-32
- C1 -
-
4O0R
1
PAK1_HUMAN
A:
[28-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
-
D
V
A
-
T
G
Q
E
V
A
I
K
Q
M
---
N
L
Q
---
Q
Q
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
----
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
--------
T
--------
C
---
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
-
S
-
N
--
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
--
F
C
---
A
Q
I
T
P
E
Q
S
--
K
R
S
E
---
M
V
-
G
T
P
Y
W
M
A
P
E
V
V
T
R
-
K
--
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
-------
L
N
E
N
P
L
R
A
L
Y
L
I
A
---
T
N
G
T
P
E
L
Q
N
P
E
K
L
S
A
I
F
R
D
F
-
L
N
R
C
L
E
M
D
V
E
K
R
-----
G
S
A
K
E
L
L
Q
H
Q
F
L
-------------------------------------------------------------------
10
PsiBlast_PDB
65.54
31%
-37
- C1 -
-
3FY0
1
PAK1_HUMAN
A:
[28-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
-
D
V
A
-
T
G
Q
E
V
A
I
R
Q
M
---
N
L
Q
---
Q
Q
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
----
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
--------
T
--------
C
---
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
-
S
-
N
--
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
--
F
C
---
A
Q
I
T
P
E
Q
-----
S
K
R
S
T
M
V
-
G
T
P
Y
W
M
A
P
E
V
V
T
R
-
K
--
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
-------
L
N
E
N
P
L
R
A
L
Y
L
I
A
---
T
N
G
T
P
E
L
Q
N
P
E
K
L
S
A
I
F
R
D
F
-
L
N
R
C
L
E
M
D
V
E
K
R
-----
G
S
A
K
E
L
L
Q
H
Q
F
L
-------------------------------------------------------------------
5
PsiBlast_PDB
65.13
31%
-28
- C1 -
-
4O0T
1
PAK1_HUMAN
A:
[28-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
-
D
V
A
-
T
G
Q
E
V
A
I
K
Q
M
---
N
L
Q
---
Q
Q
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
----
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
--------
T
--------
C
---
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
-
S
-
N
--
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
--
F
C
---
A
Q
I
T
P
E
Q
S
--
K
R
S
E
---
M
V
-
G
T
P
Y
W
M
A
P
E
V
V
T
R
-
K
--
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
-------
L
N
E
N
P
L
R
A
L
Y
L
I
A
---
T
N
G
T
P
E
L
Q
N
P
E
K
L
S
A
I
F
R
D
F
-
L
N
R
C
L
E
M
D
V
E
K
R
-----
G
S
A
K
E
L
L
Q
H
Q
F
L
-------------------------------------------------------------------
19
PsiBlast_PDB
64.48
31%
-31
- C1 -
-
4ZY4
1
PAK1_HUMAN
A:
[29-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
-
D
V
A
-
T
G
Q
E
V
A
I
K
-----------
Q
Q
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
----
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
--------
T
--------
C
---
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
-
S
-
N
--
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
--
F
C
---
A
Q
I
T
P
E
Q
-----
S
K
R
S
T
M
V
-
G
T
P
Y
W
M
A
P
E
V
V
T
R
-
K
--
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
-------
L
N
E
N
P
L
R
A
L
Y
L
I
A
---
T
N
G
T
P
E
L
Q
N
P
E
K
L
S
A
I
F
R
D
F
-
L
N
R
C
L
E
M
D
V
E
K
R
-----
G
S
A
K
E
L
L
Q
H
Q
F
L
-------------------------------------------------------------------