@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_32_1080: (2018-03-12 )
MRAKRPLRKSGPCFDLAGLMDHAAPELQVQQKNEQELNKFFIDVDDNTVSPMITTGPSFCATNTAGLSSNNSTVELTAREMAGTGSSASVEKRTMVSSQNEAKFIHVNDTNIFVLIDGISMFVEGKSTFTGTEDARLLVERLRQKKLARSVDTVQEAILNIQMSADHCDRKETAPVVSAVPSGSPVVPAEASPRQSTANTLPTSVPPLQSAVAPTALPVPLPPPQPVPIANPWASLFEDAKVPSGSPLFRSFKAKSLGSTSSHGFPPVHSTLLCESAETGATPSSPATTISPVTVTTPTSALSPTTGFNASSRLTHSVSFPSLRHQDSSSSLLSATSGAGHRHGGHASRGAAARRTKQISAEEIGHSNCSLDMDEVAVEAMIGKGTQGTVFRVRLDGKLYALKCMNIDEAMNATNDVERQGYKKGLVKELTMITLQRSRPSPAYLMQMFNAVASLDAEKKQLSILMELMSFTVENIQQMVSRIPSEELMRVTQSTFRNYMSGDPSAKQSMKECCKDQLLYGSPRHALGRSTYKEPAAWEKNVKRETPMPEVLLSMLARDVLMGLNELHTDYSIIHCDLKPANVMLCYDQQKFKLADFGCGSVMEDHQHVERRGIDLGTILYKAPERFVANILHRIADIDDGGTGEAVVFTAKADVWSLGIMLMELAAGIHPCDQFKSDFWNYSTMLKLSKMVKPLNWSESFYDFILRSVCVDVSLRWSVQQLLKHPFIIKFNHVPREKLKLFVQRLEADSKTFHKRQQSELLKEQILLSTTRRHKDTFQLQSRKVWSTYTAYLKQAPPTKDQTMFPELRHT
Atome Classification :
(28 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390...-----.--...400.......410.......420.......430.......440.......450....--...460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......-570--.......580......---.--590.......600.......-------------------610.......620.......630.......640.......650.......660.......670...--.....680-.......---------------------.--.-------690-------.--.--.--.--.---....700.......710...---..-----..720....-------------....730..-.....740-.......750.......760.......770........780.......790.......800.......810
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MRAKRPLRKSGPC
F
D
L
A
G
L
M
DHAAP
E
L
Q
V
QQK
N
E
Q
E
L
N
K
F
F
I
DVDDNTVS
P
M
ITTGPSFCATNTAGLSSNN
S
T
V
E
L
T
A
R
E
MAGTGSSAS
V
E
K
R
T
MVSSQNE
A
K
F
I
H
VND
T
N
I
F
V
L
IDG
I
S
M
F
VEGKSTFTGT
E
D
A
R
L
L
V
E
R
L
R
Q
K
K
L
A
R
S
V
D
T
V
Q
E
A
I
L
N
I
Q
MSADHCDRKETA
P
V
V
SAVPSGSPVVPAEASPRQSTANTLPTSVP
P
L
Q
SAVAPTALPVPLPPPQPVPIAN
P
W
A
S
L
F
E
DAKVPSG
S
P
L
F
R
S
F
K
A
KSLGSTSSHGFPPV
H
S
T
L
LCESAETGATPSSPA
T
T
I
S
P
V
T
V
TTPTSALSPTTGFNASS
R
L
T
H
SVSFPSLRHQDSSS
S
L
L
SATSGAGHRHGGHASRG
A
A
A
R
RTKQI
S
A
E
EIGHSNCSL
D
M
D
E
V
A
V
E
A
M
IGKGTQG
T
V
F
R
V
R
L-----D--
G
K
L
Y
A
L
K
CM
N
I
D
E
A
MNAT
N
D
V
E
R
Q
G
Y
K
K
G
L
V
K
E
L
T
M
I
T
L
QRSRP
S
P
A
Y
L
M
Q
M
F
N
A
V
A
SLD--
A
E
K
K
Q
L
S
I
L
M
E
L
M
S
F
T
V
E
N
I
Q
Q
M
V
S
RI
P
S
E
E
L
M
R
V
T
Q
S
T
F
R
N
YMSGDP
S
A
K
Q
S
M
K
E
C
C
K
DQLLYGS
P
R
H
ALGRSTYKEPA
A
W
E
KNVKRETP
M
P
E
V
L
L
S
M
L
A
R
D
V
L
M
G
L
N
E
LHT-D
Y
S
--
I
I
H
CDLKPA
N
V
M
L
C
YD---Q--Q
K
F
K
L
ADFG
C
G
S
V
M
E
D
H
Q
H
V
-------------------
E
R
RGID
L
G
T
I
L
Y
K
A
P
E
R
F
V
A
N
I
L
H
R
I
ADIDDGGTG
E
A
V
V
F
T
AKA
D
V
W
S
L
G
I
M
L
M
E
L
A
AGIH
P
-
C
D
Q
--
F
K
S
D
FW---
N
Y
S
T
M
L
K
---------------------
L
--
S
-------
K
---------
M
--V--K--P--L---NW
S
E
S
F
Y
D
F
I
L
R
S
V
C
VD
V
S
L
---
R
W
-----
S
V
Q
-
Q
L
L
KH-------------
P
F
I
I
K
FNHV-
P
R
E
K
L
K
L
F
-
V
Q
R
LEAD
S
K
T
F
H
K
R
Q
Q
S
E
L
L
K
E
Q
I
L
L
S
T
-
T
R
RHK
D
T
F
Q
L
Q
S
R
K
V
W
S
T
Y
T
A
Y
L
KQAPPTKDQTMFPELRHT
24
HHSearch
71.21
24%
-25
- C1 -
-
4WOT
1
ROCK2_HUMAN
B:
[66-339]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
A
E
D
Y
D
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
-----
K
AS
Q
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
-------
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
A
N
--
S
-
P
-
W
V
V
Q
L
F
Y
A
F
Q
------
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
-------------------------------------------------
D
L
V
N
L
M
S
N
----------------
Y
D
V
P
E
K
W
A
K
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
-
G
--
L
I
H
R
D
V
K
P
D
N
M
L
L
D
K
H
---
G
---
H
L
K
L
A
D
F
G
T
C
M
K
M
D
E
T
G
M
--------------------
V
H
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
G
-------------
G
D
G
F
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
-
F
Y
A
--
D
S
L
V
-
G
---
T
Y
S
K
I
M
D
---------------------
H
K-
N
-------
S
---------
L
CF
P
--
E
--
D
--
A
---
E
I
S
K
H
A
K
N
L
I
C
A
F
L
T
D
R
E
V
R
LG-
R
N
-----
G
V
E
-
E
I
R
Q
H
-------------
P
F
F
K
N
D
Q
----------------------------------------------------------------------------------
29
HHSearch
70.11
26%
-46
- C1 -
-
5J5T
1
M4K3_HUMAN
A:
[4-269]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
F
E
L
I
Q
R
I
G
S
G
T
Y
G
D
V
Y
K
A
R
N
VN---
T
--
G
E
L
A
A
I
K
V
I
K
L
E
P
G
----------
E
D
F
A
V
V
Q
Q
E
I
I
M
M
K
D
C
K
--
H
-
P
-
N
I
V
A
Y
F
G
S
Y
L
R
------
R
D
K
L
W
I
C
M
E
F
C
G
G
G
-------------------------------------------------
S
L
Q
D
I
Y
H
V
T
---------------
G
P
L
S
E
L
Q
I
A
Y
V
S
R
E
T
L
Q
G
L
Y
Y
L
H
S
-
K
-
G
--
K
M
H
R
D
I
K
G
A
N
I
L
L
T
D
N
---
G
---
H
V
K
L
A
D
F
G
V
S
A
Q
I
T
A
T
I
A
------------------------
A
F
I
G
T
P
Y
W
M
A
P
E
V
A
A
V
E
--------------
R
K
G
G
Y
N
Q
L
C
D
L
W
A
V
G
I
T
A
I
E
L
A
E
L
Q
P
P
-
M
F
D
--
L
H
P
M
R
----
A
L
F
L
M
T
K
S
N
F
Q
-----------------
P
--
P
-------
K
---------
L
--
K
--
D
--
K
--
M
---
K
W
S
N
S
F
H
H
F
V
K
M
A
L
T
K
N
P
K
K
---
R
P
-----
T
A
E
-
K
L
L
Q
H
-------------
P
F
V
T
Q
H
L
----------------------------------------------------------------------------------
37
HHSearch
68.17
20%
-42
- C1 -
-
1J1B
1
GSK3B_HUMAN
B:
[54-344]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
-----
C
DS
G
E
L
V
A
I
K
K
V
L
Q
D
K
--------------
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
--
H
-
C
-
N
I
V
R
L
R
Y
F
F
Y
S
S
G
EK
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
--------------------------------------------------
Y
R
V
A
R
H
-----------
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
-
F
-
G
--
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
---
T
--
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
----------------------
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
----------------
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
-
F
P
G
--
D
S
G
V
D
----
Q
L
V
E
I
I
K
V
LGTPT
R
E
Q
I
R
E
M
NPNYTEFK
F
--
P
QIKAHP
W
T
---------
K
--
V
--
F
--
R
--
P
---
R
T
P
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
---
R
L
-----
T
P
L
-
E
A
C
A
H
-------------
S
F
F
D
E
L
R
----------------------------------------------------------------------------------
46
HHSearch
65.93
22%
-46
- C1 -
-
5F9E
1
KPCT_HUMAN
A:
[15-280]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
K
I
E
D
F
E
L
H
K
M
L
G
K
G
S
F
G
K
V
F
L
A
E
F
-----
K
KT
N
Q
F
F
A
I
K
A
L
K
K
D
V
V
L
M
-------
D
D
D
V
E
C
T
M
V
E
K
R
V
L
S
L
A
W
-
E
H
-
P
-
F
L
T
H
M
F
C
T
F
Q
T
------
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
-------------------------------------------------
D
L
M
Y
H
I
Q
S
C
---------------
H
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
-
G
--
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
D
---
G
---
H
I
K
I
A
D
F
G
M
C
K
E
N
M
L
G
D
A
---------------------
K
T
N
E
F
C
G
T
P
D
Y
I
A
P
E
I
L
L
G
-----------------
Q
K
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
S
P
-
F
H
G
--
Q
D
E
E
E
L
----
F
H
-
S
I
R
---------------------
M
--
D
-------
N
---------
P
--
F
--
Y
--
P
--
R
---
W
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
---
R
L
-----
G
V
R
G
D
I
R
Q
H
-------------
P
L
F
R
E
I
N
W
---------------------------------------------------------------------------------
33
HHSearch
65.51
22%
-43
- C1 -
-
4RA5
3
KPCT_HUMAN
A:
[3-266]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
E
D
F
E
L
H
K
M
L
G
K
G
S
F
G
K
V
F
L
A
E
F
-----
K
KT
N
Q
F
F
A
I
K
A
L
K
K
D
V
V
L
M
-------
D
D
D
V
E
C
T
M
V
E
K
R
V
L
S
L
A
W
-
E
H
-
P
-
F
L
T
H
M
F
C
T
F
Q
------
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
-------------------------------------------------
D
L
M
Y
H
I
Q
S
---------------
C
H
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
-
G
--
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
D
---
G
---
H
I
K
I
A
D
F
G
M
C
K
E
N
M
L
G
D
A
---------------------
K
T
N
E
F
C
G
T
P
D
Y
I
A
P
E
I
L
L
G
-----------------
Q
K
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
S
P
-
F
H
G
--
Q
D
E
E
E
L
----
F
H
-
S
I
R
---------------------
M
--
D
-------
N
---------
P
--
F
--
Y
--
P
--
R
---
W
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
---
R
L
-----
G
V
R
G
D
I
R
Q
H
-------------
P
L
F
R
E
I
N
W
---------------------------------------------------------------------------------
32
HHSearch
65.23
23%
-41
- C1 -
-
3C0I
1
CSKP_HUMAN
A:
[23-294]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
-----
R
ET
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
-----
S
P
G
L
S
T
E
D
L
K
R
E
A
S
I
C
H
M
L
K
--
H
-
P
-
H
I
V
E
L
L
E
T
Y
S
------
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
-------------------------------------------------
D
L
C
F
E
I
V
K
R
A
-----------
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
-
N
-
N
--
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
---
E
NS
A
P
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
S
G
L
---------------------
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
R
-----------------
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
-
F
Y
G
--
T
K
E
R
L
-----
F
E
G
I
I
K
---------------------
G
--
K
Y
K
M
----
N
---------
P
--
R
--
Q
--
W
--
S
---
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
---
R
I
-----
T
V
Y
-
E
A
L
N
H
-------------
P
W
L
K
E
R
D
----------------------------------------------------------------------------------
47
HHSearch
65.19
21%
-45
- C1 -
-
4JS8
5
A:
[7-279]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
R
I
Y
S
I
L
K
Q
I
G
S
G
G
S
S
K
V
F
Q
V
L
N
-----
E
K-
K
Q
I
Y
A
I
K
Y
V
N
L
E
E
A
D
--------
N
Q
T
L
D
S
Y
R
N
E
I
A
Y
L
N
K
L
Q
Q
H
S
-
D
-
K
I
I
R
L
Y
D
Y
E
I
T
------
D
Q
Y
I
Y
M
V
M
E
C
G
N
I
--------------------------------------------------
D
L
N
S
W
L
K
K
---------------
K
K
S
I
D
P
W
E
R
K
S
Y
W
K
N
M
L
E
A
V
H
T
I
H
Q
-
H
-
G
--
I
V
H
S
D
L
K
P
A
N
F
L
I
V
D
-------
G
M
L
K
L
I
D
F
G
I
A
N
Q
M
Q
P
D
T
---------------------------
V
G
T
V
N
Y
M
P
P
E
A
I
K
D
M
S
----------------
K
I
S
P
K
S
D
V
W
S
L
G
C
I
L
Y
Y
M
T
Y
G
K
T
P
-
F
Q
Q
--
I
I
N
Q
I
S
---
K
L
H
A
I
I
D
P--------------------
N
--
H
-------
E
---------
I
--
E
--
F
--
P
--
D
---
I
P
E
K
D
L
Q
D
V
L
K
C
C
L
K
R
D
P
K
Q
---
R
I
-----
S
I
P
-
E
L
L
A
H
-------------
P
Y
V
Q
I
------------------------------------------------------------------------------------
28
HHSearch
65.13
24%
-25
- C1 -
-
3V8S
1
ROCK1_HUMAN
D:
[67-337]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
-----
K
ST
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
-------
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
A
N
--
S
-
P
-
W
V
V
Q
L
F
Y
A
F
Q
D
------
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
-------------------------------------------------
D
L
V
N
L
M
S
N
----------------
Y
D
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
-
G
--
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
---
G
---
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
E
G
M
--------------------
V
R
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
G
-------------
G
D
G
Y
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
-
F
Y
A
--
D
S
L
V
-
G
---
T
Y
S
K
I
M
N
---------------------
H
K-
N
-------
S
---------
L
--
T
--
F
PD
D
--
N
---
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
D
R
E
V
R
LG-
R
N
-----
G
V
E
-
E
I
K
R
H
-------------
L
F
F
K
N
D
Q
----------------------------------------------------------------------------------
31
HHSearch
64.42
23%
-43
* C1 *
-
3C0G
1
CSKP_HUMAN
B:
[23-294]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
-----
R
ET
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
-----
S
P
G
L
S
T
E
D
L
K
R
E
A
S
I
C
H
M
L
K
--
H
-
P
-
H
I
V
E
L
L
E
T
Y
S
------
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
-------------------------------------------------
D
L
C
F
E
I
V
K
R
A
-----------
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
-
N
-
N
--
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
---
E
NS
A
P
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
S
G
L
---------------------
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
R
-----------------
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
-
F
Y
G
--
T
K
E
R
L
-----
F
E
G
I
I
K
---------------------
G
--
K
YKM----
N
---------
P
--
R
--
Q
--
W
--
S
---
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
---
R
I
-----
T
V
Y
-
E
A
L
N
H
-------------
P
W
L
K
E
R
D
----------------------------------------------------------------------------------
36
HHSearch
64.28
22%
-28
- C1 -
-
2Y7J
1
PHKG2_HUMAN
D:
[93-364]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
RA---
T
--
G
H
E
F
A
V
K
I
M
E
V
---
R
L
--
S
P
E
Q
L
E
E
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
A
G
-
H
-
P
-
H
I
I
T
L
I
D
S
Y
E
------
S
S
S
F
M
F
L
V
F
D
L
M
R
K
G
-------------------------------------------------
E
L
F
D
Y
L
T
E
---------------
K
V
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
-
N
-
N
--
I
V
H
R
D
L
K
P
E
N
I
L
L
D
D
N
------
M
Q
I
R
L
S
D
F
G
F
S
C
H
L
E
P
G
E
----------------------
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
C
S
M
-----------
D
E
T
H
P
G
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
-
F
W
H
--
R
R
Q
I
L
----
M
L
R
M
I
M
E
---------------------
G
--
Q
Y------
Q
---------
F
--
S
--
S
PE
W
--
D
---
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
---
R
L
-----
T
A
E
-
Q
A
L
Q
H
-------------
P
F
F
E
-------------------------------------------------------------------------------------
35
HHSearch
64.20
22%
-25
- C1 -
-
4GV1
5
AKT1_HUMAN
A:
[7-278]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
-----
K
AT
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
-------
A
K
D
E
V
A
H
T
L
T
E
N
R
V
L
Q
N
S
R
--
H
-
P
-
F
L
T
A
L
K
Y
S
F
Q
------
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
-------------------------------------------------
E
L
F
F
H
L
S
R
---------------
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
-
N
--
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
---
G
---
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
A
---------------------
T
M
K
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----------------
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
-
F
Y
N
--
Q
D
H
E
K
-----
L
F
E
L
I
L
---------------------
M
--
E
-------
E
---------
I
--
R
--
F
--
P
--
R
---
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
---
R
L
GGGS
E
D
A
K
-
E
I
M
Q
H
-------------
R
F
F
A
G
I
V
W
---------------------------------------------------------------------------------
34
HHSearch
63.67
22%
-25
- C1 -
-
2Y7J
1
PHKG2_HUMAN
C:
[93-364]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
RA---
T
--
G
H
E
F
A
V
K
I
M
E
V
T
A
E
R
L
S
--
P
E
Q
L
E
E
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
A
G
-
H
-
P
-
H
I
I
T
L
I
D
S
Y
E
------
S
S
S
F
M
F
L
V
F
D
L
M
R
K
G
-------------------------------------------------
E
L
F
D
Y
L
T
E
---------------
K
V
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
-
N
-
N
--
I
V
H
R
D
L
K
P
E
N
I
L
L
D
D
N
------
M
Q
I
R
L
S
D
F
G
F
S
C
H
L
E
P
G
E
----------------------
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
C
S
M
-----------
D
E
T
H
P
G
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
-
F
W
H
--
R
R
Q
I
L
----
M
L
R
M
I
M
E
---------------------
G
Q-
Y
-------
Q
---------
F
--
S
SP
E
--
W
--
D
---
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
---
R
L
-----
T
A
E
-
Q
A
L
Q
H
-------------
P
F
F
E
-------------------------------------------------------------------------------------
23
HHSearch
58.54
22%
-10
- C1 -
-
5O2C
4
WNK3_HUMAN
A:
[20-289]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
S
P
S
G
R
F
L
K
F
D
I
E
L
G
R
G
A
F
K
T
V
Y
K
G
L
D
-----
T
ET
W
V
E
V
A
W
C
E
L
Q
D
R
K
L
T
--------
K
A
E
Q
Q
R
F
K
E
E
A
E
M
L
K
G
L
Q
--
H
-
P
-
N
I
V
R
F
Y
D
S
W
E
S
I
L
--
K
G
K
K
C
I
V
L
V
T
E
L
M
T
S
G
-------------------------------------------------
T
L
K
T
Y
L
K
R
---------------
F
K
V
M
K
P
K
V
L
R
S
W
C
R
Q
I
L
K
G
L
Q
F
L
H
T
-
R
-
T
PP
I
I
H
R
D
L
K
C
D
N
I
F
I
T
G
P
---
T
--
G
S
V
K
I
G
D
L
G
L
A
T
L
M
R
T
S
-----------------------
F
A
K
S
V
I
G
T
P
E
F
M
A
P
E
M
Y
E
------------------
E
H
Y
D
E
S
V
D
V
Y
A
F
G
M
C
M
L
E
M
A
T
S
E
Y
P
-
Y
S
E
--
C
Q
N
A
A
Q
---
I
Y
R
K
V
T
S
G--------------------
I
--
K
-------
P
---------
A
--
S
--
F
--
N
--
K
---
V
T
D
P
E
V
K
E
I
I
E
G
C
I
R
Q
N
K
S
E
---
R
L
-----
S
I
R
-
D
L
L
N
H
-------------
A
F
F
A
E
D
T
----------------------------------------------------------------------------------
54
Fugue
58.38
20%
-38
- C1 -
-
4EUT
1
TBK1_HUMAN
A:
[2-387]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
Q
S
T
S
N
H
L
W
L
L
S
D
I
L
G
Q
G
A
T
A
N
V
F
R
G
R
H
K
K
T
G
D
L
F
A
I
K
V
F
N
N
I
S
F
L
R
--
P
V
D
V
Q
M
R
E
F
E
V
L
K
K
L
N
H
K
N
I
V
K
-
L
F
A
I
E
E
E
T
T
T
R
H
K
V
L
I
M
E
F
C
P
C
G
S
----------
L
Y
T
V
L
--
E
E
P
S
N
A
Y
G
-------------------
L
P
E
S
E
F
L
I
V
L
R
D
V
V
G
G
M
N
H
L
R
E
--
N
G
--
I
V
H
R
N
I
K
P
G
N
I
M
R
V
I
G
EDG
Q
--
S
V
Y
K
L
T
D
F
G
A
A
R
E
L
E
D
D
E
Q
F
-------------------
V
S
L
---
Y
G
T
E
E
Y
L
H
P
D
M
Y
E
R
A
V
L
D
-----------
H
Q
K
K
Y
G
A
T
V
D
L
W
S
I
G
V
T
F
Y
H
A
A
T
G
S
L
P
-
F
R
P
--
F
E
G
P
R
R
---
N
K
E
V
M
Y
K
---------------------
I
--
I
-------
T
G
KPSGAISG
V
--
Q
--
K
--
A
--
E
---
N
G
P
I
D
W
S
G
D
M
P
V
S
C
S
L
S
R
G
L
---
Q
V
-----
L
L
T
-
P
V
L
A
N
I
L
EADQEKCWG
F
D
Q
F
F
A
E
T
S
D
I
L
H
R
M
V
I
H
V
F
S
L
Q
Q
M
T
A
H
K
I
Y
I
H
S
Y
N
T
A
T
I
F
H
E
L
V
Y
K
Q
T
K
I
I
S
S
N
Q
E
L
I
Y
E
G
R
R
L
V
L
E
P
G
R
L
A
Q
H
F
P
K
T
T
E
E
N
P
I
F
V
V
S
R
E
38
HHSearch
58.00
23%
-8
- C1 -
-
1VZO
1
KS6A5_HUMAN
A:
[49-330]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
V
G
I
E
N
F
E
L
L
K
V
L
G
T
G
A
Y
G
K
V
F
L
V
R
K
ISGHD
T
--
G
K
L
Y
A
M
K
V
L
K
K
A
T
I
V
------
Q
K
A
K
T
T
E
H
T
R
T
E
R
Q
V
L
E
H
I
R
Q
-
S
-
P
-
F
L
V
T
L
H
Y
A
F
Q
------
T
E
T
K
L
H
L
I
L
D
Y
I
N
G
G
-------------------------------------------------
E
L
F
T
H
L
S
Q
---------------
R
E
R
F
T
E
H
E
V
Q
I
Y
V
G
E
I
V
L
A
L
E
H
L
H
K
-
L
-
G
--
I
I
Y
R
D
I
K
L
E
N
I
L
L
D
S
N
---
G
---
H
V
V
L
T
D
F
G
L
S
K
E
F
V
A
D
E
T
--------------------
E
R
A
Y
D
F
C
G
T
I
E
Y
M
A
P
D
I
V
R
G
G
---------------
D
---
D
K
A
V
D
W
W
S
L
G
V
L
M
Y
E
L
L
T
G
A
S
P
-
F
T
V
--
D
G
E
K
-
N
---
S
Q
A
E
I
S
R
R
--------------------
I
L
K
S
-------
E
---------
P
--
P
--
Y
--
P
--
Q
---
E
M
S
A
L
A
K
D
L
I
Q
R
L
L
M
K
D
P
K
K
---
R
L
GCGPR
D
A
D
-
E
I
K
E
H
-------------
L
F
F
Q
K
I
N
W
---------------------------------------------------------------------------------
30
HHSearch
57.42
22%
-24
- C1 -
-
4LQS
1
CBK1_YEAST
A:
[98-453]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
S
L
E
D
F
H
T
V
K
V
I
G
K
G
A
F
G
E
V
R
L
V
Q
K
-----
K
DT
G
K
I
Y
A
M
K
T
L
L
K
S
E
M
Y
-------
K
K
---------------
S
D
--
S
-
P
-
W
V
V
S
L
Y
Y
S
F
Q
------
D
A
Q
Y
L
Y
L
I
M
E
F
L
P
G
G
-------------------------------------------------
D
L
M
T
M
L
I
R
W
---------------
Q
L
F
T
E
D
V
T
R
F
Y
M
A
E
C
I
L
A
I
E
T
I
H
K
-
L
-
G
--
F
I
H
R
A
I
K
P
D
N
I
L
I
D
I
R
---
G
---
H
I
K
L
S
D
F
G
L
S
T
G
F
H
K
T
H
D
S
N
YNRQQ
I
Q
T
W
R
KSRR----
L
M
A
Y
S
T
V
G
T
P
D
Y
I
A
P
E
I
F
L
Y
-----------------
Q
G
Y
G
Q
E
C
D
W
W
S
L
G
A
I
M
Y
E
C
L
I
G
W
P
P
-
F
C
S
--
E
T
P
Q
-
E
---
T
Y
R
K
I
M
N
---------------------
F
E-
Q
-------
T
---------
L
--
Q
--
F
--
P
DD
I
---
H
I
S
Y
E
A
E
D
L
I
R
R
L
L
T
H
A
D
Q
R
LGR
H
G
-----
G
A
D
-
E
I
K
S
H
-------------
P
F
F
R
G
V
D
----------------------------------------------------------------------------------
19
PsiBlast_PDB
53.96
31%
-74
- C1 -
-
2XIK
2
STK25_HUMAN
A:
[112-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
E
E
T
Y
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
-
E
R
K
--
I
-
H
R
D
I
K
A
A
N
V
L
L
S
-
E
---
Q
--
G
D
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
---------------------
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
-----
V
I
K
Q
S
A
------------
Y
D
F
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
-------
N
S
D
L
H
---
P
M
R
V
L
F
L
---------------------
I
--
P
-------
K
---------
N
--
S
--
P
--
P
--
T
L
E
G
Q
H
S
K
P
F
K
E
F
V
E
A
C
L
N
K
D
P
R
F
---
R
P
-----
T
A
K
-
E
L
L
K
H
-------------
K
F
I
T
R
Y
-----------------------------------------------------------------------------------
9
PsiBlast_PDB
52.44
32%
-74
- C1 -
-
4FZF
1
?
B:
[95-262]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
L
R
A
G
P
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
-
E
K
K
--
I
-
H
R
D
I
K
A
A
N
V
L
L
S
-
E
---
Q
--
G
D
V
K
L
A
A
F
G
V
A
G
Q
L
T
D
T
Q
I
---------------------
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
-----
V
I
Q
Q
S
A
------------
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
-------
N
S
D
M
H
---
P
M
R
V
L
F
L
---------------------
I
--
P
-------
K
---------
N
--
N
--
P
--
P
--
T
L
V
G
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
---
R
P
-----
T
A
K
-
E
L
L
K
H
-------------
K
F
I
V
K
------------------------------------------------------------------------------------
4
PsiBlast_PDB
51.77
32%
-100
- C1 -
-
4USF
1
SLK_HUMAN
A:
[108-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
P
L
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
--
D
N
K
--
I
I
H
R
D
L
K
A
G
N
I
L
F
T
L
D
---
G
--
D
-
I
K
L
A
D
F
G
V
S
A
--
K
--------------------------------
T
P
Y
W
M
A
P
E
V
V
M
C
E
----------------
R
P
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
-
H
H
E
--
L
N
P
-------
M
R
V
L
L
K
---------------------
I
--
A
-------
K
SEPPT----
L
--
A
--
Q
--
P
--
S
---
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
---
R
W
-----
T
T
S
-
Q
L
L
Q
H
-------------
P
F
V
--------------------------------------------------------------------------------------
45
HHSearch
51.76
22%
-30
- C1 -
-
4LQQ
1
CBK1_YEAST
A:
[98-453]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
S
L
E
D
F
H
T
V
K
V
I
G
K
G
A
F
G
E
V
R
L
V
Q
K
-----
K
DT
G
K
I
Y
A
M
K
T
L
L
K
S
E
M
Y
-------
K
K
---------------
S
D
--
S
-
P
-
W
V
V
S
L
Y
Y
S
F
Q
------
D
A
Q
Y
L
Y
L
I
M
E
F
L
P
G
G
-------------------------------------------------
D
L
M
T
M
L
I
R
W
---------------
Q
L
F
T
E
D
V
T
R
F
Y
M
A
E
C
I
L
A
I
E
T
I
H
K
-
L
-
G
--
F
I
H
R
A
I
K
P
D
N
I
L
I
D
I
R
---
G
---
H
I
K
L
S
D
F
G
L
S
T
G
F
H
K
T
H
D
S
N
YL
T
M
S
N
RQQ
I
Q
T
W
R
KSRR
L
M
A
Y
S
T
V
G
T
P
D
Y
I
A
P
E
I
F
L
Y
-----------------
Q
G
Y
G
Q
E
C
D
W
W
S
L
G
A
I
M
Y
E
C
L
I
G
W
P
P
-
F
C
S
--
E
T
P
Q
E
----
T
Y
R
K
I
M
N
---------------------
F
E-
Q
-------
T
---------
L
--
Q
--
F
--
P
DD
I
---
H
I
S
Y
E
A
E
D
L
I
R
R
L
L
T
H
A
D
Q
R
LGR
H
G
-----
G
A
D
-
E
I
K
S
H
-------------
P
F
F
R
G
V
D
----------------------------------------------------------------------------------
7
PsiBlast_PDB
51.32
32%
-69
- C1 -
-
4FZA
3
STK26_HUMAN
B:
[95-262]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
L
R
A
G
P
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
-
E
K
K
--
I
-
H
R
D
I
K
A
A
N
V
L
L
S
-
E
---
Q
--
G
D
V
K
L
A
A
F
G
V
A
G
Q
L
T
D
T
Q
I
---------------------
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
-----
V
I
Q
Q
S
A
------------
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
-------
N
S
D
M
H
---
P
M
R
V
L
F
L
---------------------
I
--
P
-------
K
---------
N
--
N
--
P
--
P
--
T
L
V
G
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
---
R
P
-----
T
A
K
-
E
L
L
K
H
-------------
K
F
I
V
K
------------------------------------------------------------------------------------
5
PsiBlast_PDB
50.90
32%
-46
- C1 -
-
2UV2
6
SLK_HUMAN
A:
[129-308]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
P
L
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
--
D
N
K
--
I
I
H
R
D
L
K
A
G
N
I
L
F
T
L
D
---
G
--
D
-
I
K
L
A
D
F
G
V
-
S
A
K
N
T
R
T
-
I
-------------------
Q
R
R
D
S
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
------------
T
S
K
D
R
P
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
-
H
H
E
--
L
N
P
-------
M
R
V
L
L
K
---------------------
I
--
A
-------
K
SEPPT----
L
--
A
--
Q
--
P
--
S
---
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
---
R
W
-----
T
T
S
-
Q
L
L
Q
H
-------------
P
F
V
T
V
D
S
N
K
-
P
I
R
E
L
--------------------------------------------------------------------------
8
PsiBlast_PDB
50.40
32%
-78
- C1 -
-
4FZD
1
STK26_HUMAN
B:
[95-262]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
L
R
A
G
P
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
-
E
K
K
--
I
-
H
R
D
I
K
A
A
N
V
L
L
S
-
E
---
Q
--
G
D
V
K
L
A
A
F
G
V
A
G
Q
L
T
---------------------------
N
T
F
V
G
T
P
F
W
M
A
P
E
-----
V
I
Q
Q
S
A
------------
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
-------
N
S
D
M
H
---
P
M
R
V
L
F
L
---------------------
I
--
P
-------
K
---------
N
--
N
--
P
--
P
--
T
L
V
G
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
---
R
P
-----
T
A
K
-
E
L
L
K
H
-------------
K
F
I
V
K
------------------------------------------------------------------------------------
3
PsiBlast_PDB
50.09
32%
-39
- C1 -
-
2J51
5
SLK_HUMAN
A:
[129-308]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
P
L
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
--
D
N
K
--
I
I
H
R
D
L
K
A
G
N
I
L
F
T
L
D
---
G
--
D
-
I
K
L
A
D
F
G
V
S
A
--
K
N
T
R
T
I
-------------------
Q
R
R
D
S
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
------------
T
S
K
D
R
P
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
-
H
H
E
--
L
N
P
-------
M
R
V
L
L
K
---------------------
I
--
A
-------
K
SEPPT----
L
--
A
--
Q
--
P
--
S
---
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
---
R
W
-----
T
T
S
-
Q
L
L
Q
H
-------------
P
F
V
T
V
D
S
N
K
-
P
I
R
E
L
--------------------------------------------------------------------------
1
PsiBlast_PDB
49.26
32%
-61
- C1 -
-
2JFL
6
SLK_HUMAN
A:
[129-297]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
P
L
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
--
D
N
K
--
I
I
H
R
D
L
K
A
G
N
I
L
F
T
L
D
---
G
--
D
-
I
K
L
A
D
F
G
V
S
A
--
K
N
T
R
T
I
-------------------
Q
R
R
D
S
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
------------
T
S
K
D
R
P
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
-
H
H
E
--
L
N
P
-------
M
R
V
L
L
K
---------------------
I
--
A
-------
K
SEPPT----
L
--
A
--
Q
--
P
--
S
---
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
---
R
W
-----
T
T
S
-
Q
L
L
Q
H
-------------
P
F
V
--------------------------------------------------------------------------------------
14
PsiBlast_PDB
48.26
32%
-84
- C1 -
-
5D7A
1
TNIK_HUMAN
A:
[112-283]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
T
K
G
N
T
-
L
K
E
E
W
I
A
Y
I
C
R
E
I
L
R
G
L
S
H
L
H
Q
--
H
K
--
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
-
E
---
N
--
A
E
V
K
L
V
D
F
G
V
--------------------------------
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
A
C
D
------------
E
N
P
D
A
T
Y
D
F
K
S
D
L
W
S
L
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
M
H
P
M
R
A
L
F
L
I
PR
N
P
A
P
R
L
K
---------------------
S
--
K
-------
K
--------------------------
W
S
K
K
F
Q
S
F
I
E
S
C
L
V
K
N
H
S
Q
---
R
P
-----
A
T
E
-
Q
L
M
K
H
-------------
P
F
I
--------------------------------------------------------------------------------------
6
PsiBlast_PDB
47.60
33%
-65
- C1 -
-
3GGF
1
STK26_HUMAN
A:
[113-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
G
P
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
-
E
K
K
--
I
-
H
R
D
I
K
A
A
N
V
L
L
S
-
E
---
Q
--
G
D
V
K
L
A
D
F
G
V
A
------------------------------
R
N
T
F
V
G
T
P
F
W
M
A
P
E
-----
V
I
Q
Q
S
A
------------
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
-------
N
S
D
M
H
---
P
M
R
V
L
F
L
---------------------
I
--
P
-------
K
---------
N
--
N
--
P
--
P
--
T
L
V
G
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
---
R
P
-----
T
A
K
-
E
L
L
K
H
-------------
K
F
I
V
K
------------------------------------------------------------------------------------
12
PsiBlast_PDB
43.93
32%
-80
- C1 -
-
5AX9
1
TNIK_HUMAN
A:
[112-283]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
T
K
G
N
T
-
L
K
E
E
W
I
A
Y
I
C
R
E
I
L
R
G
L
S
H
L
H
Q
--
H
K
--
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
-
E
---
N
--
A
E
V
K
L
V
D
F
G
V
S
-----------------------------------
G
T
P
Y
W
M
A
P
E
V
I
A
C
D
------------
E
N
P
D
A
T
Y
D
F
K
S
D
L
W
S
L
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
M
H
P
M
R
A
L
F
L
I
PR
N
P
A
P
R
L
K
---------------------
S
--
K
-------
K
--------------------------
W
S
K
K
F
Q
S
F
I
E
S
C
L
V
K
N
H
S
Q
---
R
P
-----
A
T
E
-
Q
L
M
K
H
-------------
P
F
I
--------------------------------------------------------------------------------------